Medicine and Health Sciences Commons^™

Analysis Of Physician-Modified Endograft Utilization Using Online Databases And Social Media, Robert Tatum, Michael Nooromid, Paul Dimuzio, Babak Abai

Department of Surgery Faculty Papers

Background: To characterize the present landscape of physician-modified endograft (PMEG) use and the impact of an institution's investigational device exemption (IDE) status on endograft use by analyzing publication trends and social media coverage.

Methods: We used the social media platform X and three online bibliographic databases to perform a keyword search using the following terms: PMEG, physician-modified endograft, and laser fenestration. Data extracted from X and online articles included authorship, IDE protocol status, pertinent clinical outcome measures, and others. An internet search was performed to determine which institutions offered revascularization with a custom-made device within an IDE protocol and which …

Outcomes Of Laparoscopic Versus Open Pyeloplasty In Adult Population: Single Center Study From Oman, Noor N. Junejo, Khalid M.P. Albalushi, Salim R.S.N. Al-Kalbani, Najib Abudraz, Mohammed Al-Saraf, Shahid Aquil, Muhammad Farooq, Ghalib Al-Badaai, Mohamed S. Al-Marhoon, Khurram M. Siddiqui

Sultan Qaboos University Medical Journal

Objectives: This retrospective study compared the efficacy and safety of laparoscopic pyeloplasty (LP) and open pyeloplasty (OP) in adult patients with ureteropelvic junction obstruction (UPJO). Methods: Records of 46 adult patients who underwent pyeloplasty at the Department of Urology, Sultan Qaboos University Hospital, between January 2014 and December 2023 were reviewed. Patients were divided into LP and OP groups. Collected variables included age, body mass index (BMI), gender, presentation, operative duration, estimated blood loss, complications, analgesic requirement, and pain score. Postoperative pain was assessed using the Wong–Baker FACES Pain Rating Scale. Statistical analyses were performed using SPSS Version 27 (IBM …

Ai In Medical Practice And Education: A Work In Progress, John Westhoff

AI in the Classroom: A Virtual Summit

At the University of Nevada, Reno School of Medicine, we’ve been working for the past two years to integrate AI into pre-clinical medical education in ways that prepare students for the tools and challenges of future AI-augmented clinical practice. This includes formal curricular workshop exposure and guided experimentation with AI in data-driven capstone projects. In addition, ongoing projects include the pilot of a research design and workflow tool and the integration of ambient documentation into our simulation center. This session will reflect on what we’ve done, what we’re building toward, and what we’ve learned along the way, shaped by ever …

Teaching, Building, Learning: Ai In Nursing Education, Jennifer Vanderlaan, Lisa Nicholas, Necole Leland

AI in the Classroom: A Virtual Summit

The session is grounded in two guiding frameworks. The ADDIE instructional design model (Analysis, Design, Development, Implementation, Evaluation) structures how AI can be systematically integrated into teaching practice, from identifying learning needs to evaluating outcomes. The RISEN framework (Role, Input, Steps, Evaluation, Next) provides faculty with a structured method for developing effective AI prompts and maintaining academic rigor. Together, these frameworks highlight how AI can be embedded purposefully rather than opportunistically.

Participants will leave with strategies for incorporating AI into their own courses, including techniques for building equitable group work, creating adaptable case studies, and designing assignments that encourage students …

Mesenchymal Stem Cells As Cornerstones Of Regenerative Medicine: Mechanisms, Applications, And Future Perspectives, Hasan M. Agha, Mohammed A. Abdalqader, Jantson Hoh, Yacoub Wassouf, Khudhur Abbas Ahmed Al-Saadawi, Amjad Abdulhadi Mohammed, Muneer Mohammed Saleh Alsayadi

AUIQ Complementary Biological System

Regenerative medicine is a multidisciplinary domain focused on restoring, repairing, or replacing damaged tissues and organs by harnessing the body’s inherent healing abilities with sophisticated biological and technical techniques. Mesenchymal stem cells (MSCs) have become fundamental among many stem cell types because to their self-renewal, multipotency, paracrine signaling, and immunomodulatory capabilities. Their therapeutic adaptability has been shown in orthopedic, cardiovascular, neurological, dermatological, and immune-mediated illnesses, underscoring their clinical significance. Nonetheless, obstacles like donor heterogeneity, senescence during in vitro growth, restricted engraftment, and regulatory impediments persist in limiting repeatability and broad clinical use. Recent advancements are enhancing the capabilities of MSCs …

Evaluating The Pros And Cons Of Common Dental Polymers In Dentistry: Review, Ali Kadhim Wadday, Sukaina Tuama Ghafel, Lina M. Shaker

AUIQ Complementary Biological System

Dental polymers play a central role in modern dentistry, offering versatility in applications ranging from removable dentures and prosthetic frameworks to implant abutments and bioactive scaffolds. Common materials like PMMA, PEEK, and nylon are valued for their formability, cost-effectiveness, and aesthetic properties, while emerging biopolymers including chitosan and alginate offer promising biocompatible alternatives. However, both conventional and bio-based polymers exhibit limitations in terms of chemical stability, mechanical wear, and microbial adhesion. Recent advancements in polymer science have expanded the material palette through innovative biopolymer formulations and advanced surface engineering techniques such as antimicrobial coatings and nanocomposites, introducing novel solutions for …

Educating About Military Culture: Lived Experiences Of Nurse Educators, Jennifer C. Dodge

Walden Dissertations and Doctoral Studies

Despite national initiatives designed to expand healthcare programs and resources for veterans, there is a lack of knowledge about military culture and health problems specific to this demographic among registered nurses who serve in a role to impact the suicide rate among the veteran population. The purpose of this qualitative study, guided by Leininger’s culture care theory and Benner’s novice to expert model, was to understand the lived experiences of associate degree in nursing (ADN) nurse educators in non-Veterans Health Administration-affiliated programs regarding teaching undergraduate nursing students about military veteran culture. Fifteen ADN nurse educators, selected through purposeful sampling, participated …

Altered Effort And Deconditioning Are Not Valid Explanations Of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, Todd E. Davenport, Carmen Scheibenbogen, Mark A. Zinn, Mary Dimmock, Janet Stone, Karl J. Tronstad, Øystein Fluge, Jonas Bergquist, Staci R. Stevens, David Tuller, Uta Behrends, J. Mark Van Ness, Mark A. Vink, Luis Nacul

Pacific Faculty Work

No abstract provided.

Evaluation Of Over-The-Counter Cutaneous Lidocaine Cream For Temporary Deafferentation In Upper Limb Rehabilitation: A Cross-Sectional Study, Kelsey Baker, Daniel Salinas, Maria Lozano Bonilla, Jared Hensley, Hunter M. Butler, Monica Lozano Garcia, Chelsea Erazo Macias, Ashley Tijerina, Victoria Cuello, Bharathi Gadad

School of Medicine Publications

Introduction: Topical or cutaneous methods of temporary deafferentation (TD) have shown potential as a tool to augment the effects of rehabilitative approaches for neurological conditions. TD has been suggested to achieve such effects due to its ability to suppress activity from afferent input that may be inhibitory to rehabilitative processes. However, most approaches to date have utilized prescription-grade anesthetic agents, which may be difficult to translate to routine outpatient rehabilitation or in remote settings. Here, we sought to evaluate whether TD could be achieved with readily available over-the-counter (OTC) 5% lidocaine topical anesthetic. We targeted the biceps brachii for TD, …

From Classroom To Clinic: Innovative Strategies To Develop And Assess Clinical Readiness And Student Success, Megan Frazee, Nicole M. Sleddens, Tessa M. Wells

Posters and Presentations: Physical Therapy

Clinical education readiness is a foundational expectation in physical therapist education and a core requirement of CAPTE accreditation. In response to national concerns regarding variability in student preparedness, the American Council of Academic Physical Therapy published a set of core knowledge, skills, and abilities (KSAs) that students should demonstrate prior to beginning full-time clinical experiences. Many of these KSAs emphasize competencies within the affective domain, such as adherence to professional standards and effective communication. Clinical reasoning is also highlighted as a key component essential for clinical readiness. However, these competencies are often underemphasized and difficult to assess prior to clinical …

Your Brain On Nature: The Healing Power Of The Outdoors, University Of Dayton. Department Of Counselor Education And Human Services

Documents of the Brain Health Collective

This flyer promotes a professional development/CEU opportunity hosted by the Brain Health Collective featuring Scott Hall, Ph.D., LPCC-S. This interactive session will explore the science behind nature’s impact on the brain and provide mental health providers with strategies to incorporate outdoor activities into their therapeutic approaches.

Fine Mapping Regulatory Variants By Characterizing Native Cpg Methylation With Nanopore Long-Read Sequencing, Yijun Tian, Shannon K. Mcdonnell, Lang Wu, Nicholas B. Larson, Liang Wang

School of Medicine Faculty Publications

5-Methylcytosine (5mC) is the most common DNA modification in the human genome. Bisulfite conversion combined with short-read sequencing captures this modification at single-nucleotide resolution but introduces PCR duplication bias and limits co-methylation analysis between distant cytosines. To resolve these limitations, we used nanopore long-read sequencing to profile human methylation and performed long-range co-methylation analysis with native DNA modification information. We analyzed the nanopore demo data in the adaptive sampling sequencing targeting the CpG islands and applied the linkage disequilibrium (LD) R to identified methylation haplotype blocks (MHBs). We found that the cancer genome exhibited significantly smaller MHBs, higher CpG density, …

Association Between Diabetes Mellitus, Hypertension, Obesity, And Diagnosis Of Covid-19 In Puerto Rico, Julian Rene Rivera Rodriguez

Walden Dissertations and Doctoral Studies

The population of Puerto Rico has been heavily affected by chronic diseases; however, data remains limited on the influence of diabetes mellitus (DM), hypertension, and obesity on the probability of COVID-19 diagnosis. The purpose of this quantitative study was to evaluate the association between non-communicable diseases that included DM, obesity, hypertension, and COVID-19 diagnosis, controlling for age and sex and person exposure in Puerto Rico. The sample consisted of 1,463 participants who underwent a polymerase chain reaction (PCR) test for COVID-19 from April 1, 2020, to March 31, 2021. Results from adjusted multivariable logistic regression analyses established that obesity OR …

Assessing The Cardiac Safety Of A Multimodal Protocol For 'Tranq Dope' Withdrawal: A Retrospective Qtc Analysis, Kory London, Emily Deschler, Sabrina Butt, Steven Graver, Jake Figaniak, Nathan Hersh, Ariana Rucker, Bogdan Popa, Jenna Hoopes, Jennifer Kahoud, Behzad Pavri

Department of Emergency Medicine Faculty Papers

BACKGROUND: "Tranq dope"-fentanyl adulterated with xylazine-has complicated the management of opioid withdrawal in emergency departments (EDs). A novel withdrawal protocol was implemented to address these challenges, utilizing concurrent agents to intentionally synergize and potentiate effects. Questions remain about the safety of its components, some of which may prolong the QT interval.

METHODS: We conducted a retrospective cohort study of adult ED patients with suspected fentanyl/xylazine exposure treated utilizing novel protocol across two urban hospitals in Philadelphia, PA between September 2022 and October 2024. Patients with both pre- and post-treatment electrocardiograms (ECGs) were included. QTc intervals were reviewed by an experienced …

Aprepitant For Oculoplastic Surgeries, Kevin Wu, Dianne Schlachter, Evan Black

Conference Presentation Abstracts

No abstract provided.

Regorafenib Pulmonary Toxicity: A Case Of Cavitary Lung Disease And Ards Treated With Infliximab, Michael Dong, Mackenzie Kramer, Tanmay Gandhi, Gautam George

Division of Pulmonary, Allergy, and Critical Care Medicine Faculty Papers

Regorafenib-induced pneumonitis and acute respiratory distress syndrome (ARDS) are rare and poorly characterized toxicities. We describe a 43-year-old male with metastatic colorectal cancer who developed hypoxic respiratory failure after two cycles of regorafenib. Imaging revealed cavitary lung lesions and diffuse ground glass opacities. Despite antibiotics and high-dose corticosteroids, his condition deteriorated, requiring ICU admission and mechanical ventilation. Bronchoalveolar lavage revealed bacterial pathogens, and he was treated for pneumonia. After multidisciplinary discussion, he was assessed to have regorafenib-induced pneumonitis as a major driver of his respiratory failure, and after limited steroid response, infliximab was administered with marked respiratory improvement. However, he …

Intracellular Lactate Dynamics In Drosophila Neurons, Matthew S Price, Elham Rastegari, Richa Gupta, Katie Vo, Travis I Moore, Kartik Venkatachalam

Faculty, Staff and Student Publications

Rates of lactate production and consumption reflect the metabolic state of many cell types, including neurons. Here, we investigated the effects of nutrient deprivation on lactate dynamics in Drosophila neurons by leveraging the limiting effects of the unstirred layer, a diffusion barrier that forms around cells in culture. We found that neurons constitutively consume lactate when the availability of trehalose, a glucose disaccharide preferred by insects, is limited by the unstirred layer. Acute mechanical disruption of the unstirred layer reduced this reliance on lactate. Through kinetic modeling and experimental validation, we demonstrate that neuronal lactate consumption rates under unstirred layer …

Interventions To Minimize Unnecessary Antibiotic Use For Acute Otitis Media: A Meta-Analysis., Theresa L. Morin, Amy B. Stein, Rana El Feghaly, Amanda Nedved, Sophie E. Katz, Amy Keith, Heather E. Laferriere, Timothy C. Jenkins, Holly M. Frost

Manuscripts, Articles, Book Chapters and Other Papers

Backgrounds/Objectives: Acute otitis media (AOM) is the leading reason antibiotics are prescribed to children. Despite guidelines advocating for watchful waiting and shorter antibiotic durations, overprescribing remains a concern. This meta-analysis aims to quantify potential reduction in antibiotic days of therapy (DOT) for AOM if prescribers adhered to guidelines. Methods: Cochrane databases were sourced for studies on ear infections, diagnostic accuracy, antibiotic duration, and watchful waiting. Randomized clinical trials, observational studies, and quality improvement reports of children aged 6 months-17 years with uncomplicated AOM published between 2000 and 2024 from the U.S., Canada, and Europe. Of 4187 studies, 425 met selection …

Nucleotide Motif-Guided Selection Of Plasma Microrna Biomarkers In Trauma, Boyang Ren, Ruoxing Li, Chien-Yu Lin, Chanhee Park, Sheng Wang, Andrew O Suen, John Kessler, Shiming Yang, Rosemary Kozar, Lin Zou, Brittney Williams, Ziyi Li, Peter Hu, Wei Chao

Faculty, Staff and Student Publications

Trauma remains a leading cause of morbidity and mortality in part due to complex pathophysiological responses. Yet our abilities to predict these changes are limited. Plasma miRNAs have been proposed as DAMPs that drive immune response and organ injury. Here, we test a panel of plasma miRNAs-selected based on next-generation sequencing and nucleotide motifs identified via a machine-learning algorithm-for their abilities to predict subclinical pathophysiological injuries. We find marked and severity-dependent increases in the miRNA biomarkers following trauma, which are closely associated with various injury markers. AUROC indicates that these biomarkers possess strong diagnostic and predictive abilities in overall trauma …

Visualization Of Lysosomal Membrane Proteins By Cryo Electron Tomography, Bridget M Mcveigh, José J De Jesús-Pérez, Dirk H Siepe, Prerana Gogoi, Shrawan Kumar Mageswaran, Marian Kalocsay, Elaine M Mihelc, Vera Y Moiseenkova-Bell

Faculty, Staff and Student Publications

Lysosomes are essential organelles for cellular homeostasis and signaling, with dysfunction linked to neurological disorders, lysosomal storage diseases, and cancer. While proteomics has advanced our understanding of lysosomal composition, the structural characterization of lysosomal membrane proteins in their native environment remains a significant challenge. Here, we developed a cryo electron tomography workflow to visualize lysosomal membrane proteins within intact, native lysosomal membranes. We isolated endolysosomes by independently targeting two lysosomal membrane proteins, transient receptor potential mucolipin 1 and transmembrane protein 192, enriching organelles that exhibited the expected morphology and proteomic composition of the endolysosomal system. Sub-tomogram averaging enabled the structural …

Neuro Rehab In Rural America: Interprofessional Strategies For Implementing Evidence Based Practice, Stacie Mae Larreau Christensen, Rebecca L. Kinnison, Amy J. Goldman, Colleen Spellman

Posters and Presentations: Physical Therapy

No abstract provided.

The Fast And The Very Fast: High-Frequency Oscillations In Alzheimer's Disease, Manuel Silva-Pérez, Jeannie Chin

Faculty, Staff and Students Publications

Alzheimer's disease increases the risk of developing epilepsy together with cognitive decline. Early diagnosis or prediction of parameters associated with epileptic activity can greatly help in managing disease outcomes. Network hyperexcitability is a candidate of interest as a neurophysiological biomarker of Alzheimer's disease. High-frequency oscillations are increasingly recognized as potential biomarkers of hyperexcitability and epileptic activity. However, they have not yet been identified in Alzheimer's disease. In this study, we measured high-frequency oscillations via magnetoencephalography recordings in Alzheimer's disease patients with and without epileptic activity, as part of a Phase 2a randomized, double blind clinical trial of the efficacy of …

Metabolic Impact Of Dietary Glycine Supplementation In Individuals With Severe Obesity, Hong Chang Tan, Jean W Hsu, E Shyong Tai, Shaji Chacko, Vieon Wu, Paul M Yen, Jean-Paul Kovalik, Farook Jahoor

Faculty, Staff and Students Publications

Glycine plays a central role in human metabolism, and an adequate supply is required for synthesizing glutathione (GSH), eliminating excess metabolites as acylglycine via the glycine conjugation detoxification pathway, and maintaining 1-carbon cycle activity. However, glycine is deficient in individuals with severe obesity, which may compromise these pathways and metabolic health. This exploratory study examines whether dietary glycine supplementation could correct glycine deficiency and impairments in glycine-dependent metabolic pathways. 19 participants with severe obesity (BMI 38.3 ± 5.3 kg/m2) were treated with dietary glycine (100 mg/kg/day) for two weeks. We found that treatment significantly increased the plasma concentration of glycine …

Viral Oncogenes Drive Biphenotypic Lymphoproliferative Malignancy In Transgenic Mice, Daniel A Rauch, John Harding, Ancy Joseph, Lee Ratner

2020-Current year OA Pubs

Human T-cell leukemia virus type 1 (HTLV-1) is the cause of adult T-cell leukemia/lymphoma (ATLL) and viral oncogenic proteins, Tax and Hbz, are critical drivers of malignancy. Expression of both CD2 and CD20 has been described in a subset of ATLL cases. Transgenic mice were engineered to monitor lymphoma and leukemia after expression of Hbz and doxycycline-inducible Tax in activated T cells under the regulation of the human granzyme B (GZMB) promoter. These mice spontaneously developed lymphoproliferative disease characterized by the expansion and transformation of Cd2 + Cd20 + cells resulting in lymphoma and / or leukemia with involvement of …

Cep76 Impairment At The Centrosome-Cilium Interface Contributes To A Spectrum Of Ciliopathies, Kamal Khan, Erika Tavares, Katherine Bishara, Aysegul Ozanturk, Leila Qebibo, Stephan Frangakis, Daniel G Calame, Isabelle Meunier, Béatrice Bocquet, Rafal Ploski, Mohammad Ayman Al Khateeb, Dana Marafi, Luke Mansard, Lena Damaj, Richard A Lewis, Farid Ullah, Thomas Arbogast, Jackson P Ogden, Madeleine Harion, Marjolaine Willems, Maha S Zaki, Tobias Bartolomaeus, Anne-Françoise Roux, James R Lupski, Malgorzata Rydzanicz, Rami Abou Jamra, Francis Ramond, Elise Heon, Lydie Burglen, Erica E Davis

Faculty, Staff and Students Publications

Dysfunction at the centrosome-cilium interface underlies a broad range of ciliopathies. Here, we identify biallelic variants in CEP76, encoding a centrosomal protein, in eight unrelated individuals presenting with neurodevelopmental, ocular, and variable additional multisystem features. Proband-derived fibroblasts and CEP76-depleted RPE1 cells display ciliary deficits, including impaired cilium formation and length, disrupted transition zone architecture, and impaired IFT88-mediated anterograde intraflagellar transport. Zebrafish cep76 mutants recapitulate key clinical phenotypes, and in vitro complementation assays confirm pathogenicity for all tested human disease-associated variants. Proteomics analysis identifies CEP76 interactors, including known partners CCP110 and CEP97, and highlights clinically and functionally relevant candidates, including …

From Student To Pmhnp: Your Roadmap To Certification, Practice, And Success, Dena L. Hinkle

Nursing Department Faculty Conferences

This poster presentation highlights the changes made to the final course in the Psychiatric Mental Health Nurse Practitioner program based on student and faculty feedback. Students are provided with the knowledge and tools to navigate certification, licensure, job selection, and clinical practice. Participants engagee in activities to enhance their resumes/CVs, practiced conducting intake assessments, and developed strategies for a successful transition into practice.

A Pooled Sample Study Of Opioid Use Disorder Treatment Wait Time Among A Pregnant Population In New York, Stanley Nkemjika, Gulshan Begum, Bolaji Yoade, Vaibhav Vyas, Henry Onyeaka, Olubusola Olatunji, Olaniyi Olayinka, Ayana Jordan

Department of Psychiatry and Human Behavior Faculty Papers

Background and Aim: Opioid use disorder (OUD) during pregnancy has become a major public health issue, with its prevalence rising significantly in recent years. The incidence of neonatal abstinence syndrome (NAS) has also surged, from 1.5 cases per 1000 hospital births in 1999 to 6.0 cases per 1000 in 2013. This study aims to identify and analyze the concerns faced by pregnant people in accessing OUD treatment on time, specifically focusing on New York. Methods: The pooled sample of 225,275 individuals represents pregnant patients with OUD who received treatment at substance use disorder (SUD) facilities across New York State between …

Nurse Confidence In Mental Health Communication: Examining The Effect Of An Educational Intervention In Outpatient Specialty Departments, Joy-Ruth Mathews

Doctoral Dissertations and Projects

The global prevalence of mental health illnesses has prompted a growing need for healthcare professionals to be prepared to identify and address these concerns. Many nurses in outpatient specialty departments report feeling underprepared and lacking confidence when communicating with patients about mental health concerns. This scholarly project utilized an educational intervention to improve nurse confidence in mental health communication, the application of therapeutic communication techniques, and resource identification. A quasi-experimental, one-group pretest/posttest design was implemented, with nurses from outpatient specialty departments at Duke Health’s Kernodle Clinic completing pre- and post-Likert scale surveys to assess changes in their self-reported confidence. The …

Nurse-To-Nurse Change-Of-Shift Handoff Communication: The Experience Among Senior Nursing Students In A Hospital Setting—A Transcendental Phenomenological Study, Karen Bryson

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to understand the lived experiences of senior nursing students with nurse-to-nurse change-of-shift handoff communication during their clinical practicum at a major healthcare system in the United States. The guiding research question was: What are the lived experiences of senior nursing students when communicating shift-to-shift handoff reports to incoming nurses during senior clinical practicum in an acute care hospital setting? Bandura's social cognitive theory and Kolb's experiential learning theory are the two theories that support the conceptual framework of this study. Ten nursing students were purposefully recruited from local two-year and four-year nursing …

Effect Of Water At Different Ph Levels Adjusted With Organic And Inorganic Acidifiers On The Growth Performance, Blood Biochemistry, Carcass Yield, And Meat Physicochemical Properties Of Broilers, Asad Ali Shah, Shahid Mehmood, Fazal Raziq, Muhammad Tahir Khan, Assad Ullah, Yasir Abbas, Syed Kaleem Ul Hassan, Sohail Ahmad, Smile Manzoor, Kashif Khan

Turkish Journal of Veterinary & Animal Sciences

This study evaluated the effects of varying water pH levels, adjusted with organic (formic acid) and inorganic (sodium hydrogen sulfate) acidifiers, on the growth performance, blood biochemistry, carcass yield, and meat quality of broiler chickens. The objective was to determine how these factors affect broiler health and production efficiency. In a 35-day feeding trial, 420 day-old chicks were randomly assigned to a 2 × 3 factorial design that tested two types of acidifiers (organic versus inorganic) at three pH levels (5.8, 6.8, and 7.8), with six replicates of 10 birds per treatment. Birds were provided with acidified water ad libitum …