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Full-Text Articles in Medicine and Health Sciences

Over Reliance On Antidepressant Medication In Long-Term Care Facilities: Rethinking Mental Health Approaches, Kaylene Elder Nov 2025

Over Reliance On Antidepressant Medication In Long-Term Care Facilities: Rethinking Mental Health Approaches, Kaylene Elder

Walden Dissertations and Doctoral Studies

Depression is a prevalent mental health condition among older adults in long-term care (LTC) facilities and is often managed primarily through antidepressant medications. While these medications can be effective, their overuse in elderly populations increases the risk of falls, sedation, cognitive decline, and adverse drug interactions. This project addresses the need for safer, evidence-based alternatives by promoting non-pharmacological interventions that support holistic well-being. The proposed approach integrates gratitude journaling, vitamin D testing to identify deficiencies, and vitamin D supplementation for residents experiencing mild to moderate depressive symptoms. Implementation is led by nursing staff and supported by the interdisciplinary care team, …


From Urban Models To Rural Realities: Adapting Hepatitis C (Hcv) Care For Underserved Communities, Caitlin A. Mccain Nov 2025

From Urban Models To Rural Realities: Adapting Hepatitis C (Hcv) Care For Underserved Communities, Caitlin A. Mccain

2025 Fall Honors Capstones Projects - Archive

This literature review examines how Hepatitis C (HCV) screening and care programs can better serve underserved populations, particularly Spanish-speaking rural communities in border states. The research supports the Hep C- Colonias Advancing & Restoring Esperanza (C.A.R.E) program’s mission by incorporating recent findings from 32 studies gathered through PubMed, Medline and Google Scholar. Hep C C.A.R.E expanded from the HepVISTA expansion project provides HCV screening, education, vaccination and linkage to care for uninsured patients at partner sites in Laredo and Maverick County. Results indicate that while HCV elimination is feasible, significant gaps persist among rural uninsured and minority populations. Effective strategies …


Intouch Week Of November 17, 2025, New York Medical College Nov 2025

Effect Of Workplace Diversity, Equity, And Inclusion Programs On Black Women Leaders At Nonprofit National Associations Of Regulatory Boards, Alba Gisel Ayala Nov 2025

Effect Of Workplace Diversity, Equity, And Inclusion Programs On Black Women Leaders At Nonprofit National Associations Of Regulatory Boards, Alba Gisel Ayala

Walden Dissertations and Doctoral Studies

This Doctor of Nursing Practice (DNP) project addressed a critical knowledge gap among clinical staff regarding the application of Social Determinants of Health (SDOH) within a local health department. Although SDOH screening tools and the statewide NCCARE 360 referral system were in place, inconsistent use hindered integration into patient care and limited efforts to advance health equity. Guided by the Johns Hopkins Evidence-Based Practice model and the ADDIE instructional framework, an educational intervention was developed and implemented to enhance staff knowledge, confidence, and integration of SDOH principles into workflow. Thirty-five clinical staff members participated in pre- and post-intervention assessments. Data …


Citronellol Reduces Sepsis-Induced Renal Inflammation Via Ap-1/Nf-Κb/Tnf-Α Pathway, Huda Rashid Atiyah, Sarmed H. Kathem, Surya M. Nauli Nov 2025

Citronellol Reduces Sepsis-Induced Renal Inflammation Via Ap-1/Nf-Κb/Tnf-Α Pathway, Huda Rashid Atiyah, Sarmed H. Kathem, Surya M. Nauli

Pharmacy Faculty Articles and Research

Sepsis is characterized by the over-production of pro-inflammatory cytokines. Cecal ligation and puncture (CLP) is a well-accepted model for recreating sepsis-induced renal injury in mice. The current study investigates how citronellol, a naturally occurring substance with a variety of biological characteristics, can prevent acute kidney inflammation brought on by CLP. In the CLP mouse model, citronellol was administered orally at doses of 50 and 100 mg/kg. Serum levels of creatinine and urea were used as markers of renal function, and the Murine Sepsis Score (MSS) was used to assess the severity of sepsis. According to our findings, CLP caused a …


Quality Improvement Project: Improving Competency Of Behavioral Health Technicians In Vital Sign Technique, Ashley Buescher Nov 2025

Quality Improvement Project: Improving Competency Of Behavioral Health Technicians In Vital Sign Technique, Ashley Buescher

Doctor of Nursing Practice Projects

Untreated hypertension or hypotension can lead to serious health problems, including death. Proper technique is essential when obtaining a blood pressure reading to improve patient safety. The goal of the quality improvement project was to improve competency in blood pressure technique by implementing standardized training. The initiative addressed discrepancies in blood pressure readings in the intake unit of a behavioral health hospital. Using the Stetler Model of Evidence-Based Practice and John Kotter’s 8-Step Change Model, a single sample, pre-post design was implemented over 4 weeks. The American Heart Association's blood pressure guidelines and the Teach-Back Observation Tool were used in …


Exploring Psychological Empowerment Among Hiv Support Groups, Harit Agroia, Leyla Mousli, Rock Braithwaite, Silvia Boron, Rene Padilla Nov 2025

Exploring Psychological Empowerment Among Hiv Support Groups, Harit Agroia, Leyla Mousli, Rock Braithwaite, Silvia Boron, Rene Padilla

Journal of Social, Behavioral, and Health Sciences

Support groups can provide members with space to discuss life issues, foster a sense of community, and promote connections with others. For people living with HIV, support groups can improve knowledge and awareness of tools and resources for HIV management, reduce stigma, improve social competence, and overall health. Studies that have connected empowerment and support group structures in populations with HIV have found promising results; however, a dearth of research demonstrates how applying theoretical frameworks can improve understanding of factors that increase empowerment among support group participants. The purpose of this phenomenological study was to apply the Psychological Empowerment Theory …


Introducing Neuro Sscial Work: A Brief Reflection On Neuroscience And The Profession, Priscila Llamosa Nov 2025

Introducing Neuro Sscial Work: A Brief Reflection On Neuroscience And The Profession, Priscila Llamosa

Social Work Faculty Publications

This reflection introduces and contextualizes the term Neuro Social Work, which I coin to name a specialized practice area at the intersection of social work, neuroscience, and neurodiversity. Drawing on my experience as a social work educator and practitioner, I discuss social work’s uneasy relationship with neuroscience, marked both by the opportunity to deepen our understanding of trauma, development, and healing, and by the risks of using brain‑based evidence to individualize structural harms or justify surveillance of marginalized communities. I outline, in broad strokes, what distinguishes Neuro Social Work from general neuroscience‑informed practice. The note is intended as a concept …


From Nicu To Neighborhood: Supporting Premature Patients Beyond The Hospital, Bob Underwood, Jermine Harriet Romald Nov 2025

From Nicu To Neighborhood: Supporting Premature Patients Beyond The Hospital, Bob Underwood, Jermine Harriet Romald

Pediatrics in Practice: A CME Podcast

In this episode, we chat with neonatologist Harriet Romald, MD, FAAP, to explore the critical role pediatricians play in the long-term care of premature infants. From NICU discharge to developmental milestones, we discuss how pediatricians and neonatologists collaborate to ensure continuity of care, monitor common health challenges and navigate social determinants that impact outcomes. Whether you're new to caring for former NICU patients or looking to deepen your understanding, this conversation offers practical insights and the latest updates in neonatal follow-up care.

Click here to stream the podcast episode.


Quality Improvement Project: Improving Patient Appointment Adherence Through Staff Education On Health Literacy, Christine A. Johnson- Nganbou Kamkeu Nov 2025

Quality Improvement Project: Improving Patient Appointment Adherence Through Staff Education On Health Literacy, Christine A. Johnson- Nganbou Kamkeu

Doctor of Nursing Practice Projects

Non-adherence to appointments remains an impediment to health continuity. It has been especially pervasive in rural settings. Numerous scholarly articles in the healthcare literature support enhancing health literacy in organizations and training in effective communication to promote patient appointment compliance. Hence, the purpose of the quality improvement (QI) project was not only to encourage appointment compliance but also to enhance the application of the Teach-Back Method through health literacy education. The theoretical perspective and practice application, according to Lewin’s Change Theory and the PDSA approach, included a four-week intervention period, during which the Agency for Healthcare Research and Quality (AHRQ) …


Quality Improvement Project: Responding Effectively With The Use Of A Defibrillator And Crash Cart: An Educational Intervention For Medical-Surgical Nurses, Josilyn Lusk Nov 2025

Quality Improvement Project: Responding Effectively With The Use Of A Defibrillator And Crash Cart: An Educational Intervention For Medical-Surgical Nurses, Josilyn Lusk

Doctor of Nursing Practice Projects

Appropriate and timely use of a defibrillator and crash cart is essential for patient survival during cardiac arrest, yet many medical-surgical nurses report limited preparedness due to inconsistent, non-standardized training. The purpose of this DNP project is to evaluate the impact of a structured didactic and simulation-based educational intervention on nurses’ self-assessed preparedness to respond to life-threatening events and their perceptions of educational best practices. The aim of the project is to demonstrate measurable improvements in nurses’ self-reported preparedness in responding to emergent events and their perceptions of effective teaching and learning strategies. Guided by Tanner’s Model of Clinical Judgment …


Enhancing Emergency Department Staff Competency In Ultrasound-Guided Venous Access At A Rural Critical Access Hospital: A Quality Improvement Project, Ryan M. Sand Nov 2025

Enhancing Emergency Department Staff Competency In Ultrasound-Guided Venous Access At A Rural Critical Access Hospital: A Quality Improvement Project, Ryan M. Sand

Doctor of Nursing Practice Projects

Patients meeting difficult intravenous access (DIVA) criteria often experience multiple failed intravenous (IV) access attempts, delayed diagnostics, and treatment initiation, particularly in rural emergency departments with limited resources. This quality improvement (QI) project evaluated whether targeted ultrasound-guided peripheral venous access training would improve staff self-efficacy, confidence, and self-reported procedural execution at a rural critical access hospital. Guided by Lewin’s Change Theory and Benner’s Novice to Expert Theory, a quasi-experimental pre-/post-intervention design was implemented. Nurses and paramedics completed the validated Peripheral Intravenous Insertion Confidence Assessment before and after a didactic and psychomotor training program. Statistical analysis included an independent samples t-test …


Quality Improvement Project: Debriefing In Simulation With Improved Knowledge And Confidence, Rebecca Walker Nov 2025

Quality Improvement Project: Debriefing In Simulation With Improved Knowledge And Confidence, Rebecca Walker

Doctor of Nursing Practice Projects

Debriefing is a vital part of simulation and is critical to the students' learning in the simulation environment. It is essential for faculty that debriefers receive training in simulation concepts and in structuring debriefings. The purpose is to improve the simulation program at the project site by implementing a training course, and the project aims to enhance the faculty's confidence and address any knowledge gaps. The project design is a quasi-experimental study that features pre- and post-intervention surveys. Fifteen full-time nursing educators were surveyed, excluding faculty who do not teach in simulation. The intervention includes launching a SBL course and …


Quality Improvement Project Assessment Of Emergency Department Staff Knowledge On Use Of Emergency Severity Index In A Critical Access Hospital: Implementation Of Emergency Department-Based Education Program., Amanda Taylor Nov 2025

Quality Improvement Project Assessment Of Emergency Department Staff Knowledge On Use Of Emergency Severity Index In A Critical Access Hospital: Implementation Of Emergency Department-Based Education Program., Amanda Taylor

Doctor of Nursing Practice Projects

In rural emergency departments, accurate triage is vital to ensuring patient safety and maximizing limited resources. This quality improvement project aimed to strengthen triage practices by enhancing nurses’ understanding and confidence in using the Emergency Severity Index (ESI), a standardized tool for assessing patient acuity. Ten registered nurses at a seven-bed critical access hospital participated in a structured educational program, guided by Lewin’s Change Theory and Benner’s Novice to Expert Theory. The intervention included hands-on training, real-world scenarios, and self-assessment surveys. After the program, nurses showed significant gains in both knowledge (mean scores rose from 70.0 to 88.9, p < .001) and confidence (from 13.5 to 23.2 out of 25). While the small sample size and short timeline were limitations, the results highlight the value of ongoing education in improving triage accuracy and patient care. This project offers a practical model for rural hospitals seeking to enhance emergency nursing practice and promote consistent, evidence-based decision-making.


Policy Project: Creating An Animal Assisted Therapy Policy For A College Of Nursing, Brooke Peyton Nov 2025

Policy Project: Creating An Animal Assisted Therapy Policy For A College Of Nursing, Brooke Peyton

Doctor of Nursing Practice Projects

Nursing students experience high levels of academic stress, anxiety, and burnout, which can negatively impact learning, professional development, and overall health. Evidence indicates that Animal-Assisted Therapy (AAT) has the potential to impact stress levels, improve community connection, and enhance overall well-being among nursing students. Many academic institutions lack structured policies to guide AAT programs into educational settings. The purpose of this Doctor of Nursing Practice project was to develop a formal AAT policy for the College of Nursing with standardized procedures to implement an AAT program. Rogers’ Diffusion of Innovations theoretical framework was used to guide the development of the …


Simulation Education Program For Medical Emergencies: Improving Facilitator Simulation Proficiency, Cari Kent Nov 2025

Simulation Education Program For Medical Emergencies: Improving Facilitator Simulation Proficiency, Cari Kent

Doctor of Nursing Practice Projects

This Doctor of Nursing Practice (DNP) project, Simulation Education Program for Medical Emergencies: Improving Facilitator Simulation Proficiency, addressed a critical gap in outpatient emergency preparedness among nursing leaders and facilitators. Despite established policies, many ambulatory care staff reported feeling unprepared to respond effectively to medical emergencies. Guided by the PICOT question, among nursing leaders and facilitators (P), how does a simulation education program in emergency care scenarios (I), compared to current education practices (C), impact simulation proficiency and effectiveness (O)? This quality improvement project evaluated the impact of structured simulation-based education on the competence of facilitators. Using a pre- and …


Quality Improvement Project Step Into Serenity: How Walking Can Ease Stress For Nursing Faculty, Stefanie Martinez Nov 2025

Quality Improvement Project Step Into Serenity: How Walking Can Ease Stress For Nursing Faculty, Stefanie Martinez

Doctor of Nursing Practice Projects

This quality improvement project explored whether incorporating scheduled walk breaks could help reduce perceived stress among accelerated Bachelor of Science in Nursing (ABSN) faculty. High levels of stress and burnout continue to affect nursing educators and contribute to faculty turnover and workforce shortages. The goal of this project was to promote physical activity as a simple and accessible approach to supporting well-being and fostering a healthier work environment. Grounded in George Engel’s Biopsychosocial Model of Health, this project introduced an educational session on faculty stress, burnout, and the benefits of walking. Participants completed the Perceived Stress Scale (PSS-10) before and …


11.17.2025 Ored Connect, Liz Williamson Nov 2025

11.17.2025 Ored Connect, Liz Williamson

ORED Newsletter

  • Qualtrics training sessions
  • Alcorn State University, Dr. Edmund Buckner


The Edmonton Obesity Staging System For Pediatrics (Eoss-P) In Mexican Children And Adolescents Living With Obesity: Beyond Bmi Obesity Classes, Isabel Omaña-Guzmán, Roberto Carlos Rodríguez Quintero, Arturo Ruíz-Arroyo, Edith Prado Díaz, Juan Carlos Lopez Alvarenga, Ana María Hernández López, Zendy Fuentes Corona Nov 2025

The Edmonton Obesity Staging System For Pediatrics (Eoss-P) In Mexican Children And Adolescents Living With Obesity: Beyond Bmi Obesity Classes, Isabel Omaña-Guzmán, Roberto Carlos Rodríguez Quintero, Arturo Ruíz-Arroyo, Edith Prado Díaz, Juan Carlos Lopez Alvarenga, Ana María Hernández López, Zendy Fuentes Corona

School of Medicine Publications

Background/Objectives: The Edmonton Obesity Staging System (EOSS) was developed to stage the obesity in adult populations. Subsequently, this staging system was designed for pediatric populations (EOSS-P). This study aimed to describe obesity severity using EOSS-P and correlate it with BMI classes in Mexican children and adolescents living with obesity. Methods: This is a cross-sectional analysis carried out with data from school-age children and adolescents living with obesity who were referred to the Pediatric Obesity Clinic at the Child Welfare Unit at the General Hospital of Mexico “Dr. Eduardo Liceaga”. Obesity was staged using the EOSS-P. To evaluate the association between …


Does Preoperative Arthritis Affect The Outcomes Of Superior Capsular Reconstruction? A Systematic Review, Tae-Hoon Park, Hyungsuk Kim, Sukil Kim, Jongin Lee, Gerald R. Williams, Hyun Seok Song Nov 2025

Does Preoperative Arthritis Affect The Outcomes Of Superior Capsular Reconstruction? A Systematic Review, Tae-Hoon Park, Hyungsuk Kim, Sukil Kim, Jongin Lee, Gerald R. Williams, Hyun Seok Song

Rothman Institute Papers

BACKGROUND: The optimal indications for superior capsular reconstruction (SCR) in cases of massive irreparable rotator cuff tears (RCTs) accompanied by degenerative arthritis remain controversial.

METHODS: A systematic review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, searching PubMed, Embase (Elsevier), and Google Scholar. Studies were included if they documented Hamada grade and reported clinical and radiographic outcomes after SCR for irreparable RCTs. American Shoulder and Elbow Surgeons (ASES) score, visual analog scale for pain (pVAS), active range of motion, and acromiohumeral distance (AHD) were analyzed.

RESULTS: In all 7 studies, there was no consistent …


Prevalence Of Asymptomatic Superior Semicircular Canal Dehiscence On High Resolution Ct Scan In Omani Population, Osama Al Shaili, Mohamed Badr-El-Dine, Eiman Al-Ajmi, Nasser Al Tamami, Mohammed Al Washahi, Khalid Al Zaabi Nov 2025

Prevalence Of Asymptomatic Superior Semicircular Canal Dehiscence On High Resolution Ct Scan In Omani Population, Osama Al Shaili, Mohamed Badr-El-Dine, Eiman Al-Ajmi, Nasser Al Tamami, Mohammed Al Washahi, Khalid Al Zaabi

Sultan Qaboos University Medical Journal

Objectives: Incidental detection of superior semicircular canal dehiscence (SSCD) in patients without symptoms may lead to misinterpretation if not correlated with clinical presentation, examination findings, and vestibular function testing. This study aimed to assess the rate of radiological SSCD in the asymptomatic Omani population, as the first study of its kind in the country and the Gulf region. Methods: A retrospective review was conducted of all asymptomatic patients who underwent high-resolution computed tomography (HRCT) of the temporal bones at a tertiary care facility between 2017 and 2021. Dedicated consultant neuroradiologists evaluated both superior semicircular canals (SSCs) for evidence of dehiscence. …


Quality Improvement Project: Creation Of An Ebp Healthy Lifestyle Program: An Evidence-Based Development Program, Devanee Ray Nov 2025

Quality Improvement Project: Creation Of An Ebp Healthy Lifestyle Program: An Evidence-Based Development Program, Devanee Ray

Doctor of Nursing Practice Projects

Nursing education is the foundation of healthcare itself. However, several things influence nursing students’ academic success. A lack of overall health habits is a significant contributor. Generally, this lack is due to a lack of education. The goal of this quality improvement Doctor of Nurse Practice (DNP) project was to develop an educational program that addresses the identified knowledge gaps. The aim was to develop the program to promote student success and pilot-test the program to determine its impact among masters-level nursing faculty. Using Lewin’s Change Theory and Orem’s theory of self-care, the educational program was piloted over a seven-week …


Staff Education To Improve Clinical Staff Knowledge Of The Social Determinants Of Health In A Public Health Setting, Alba Gisel Ayala Nov 2025

Staff Education To Improve Clinical Staff Knowledge Of The Social Determinants Of Health In A Public Health Setting, Alba Gisel Ayala

Walden Dissertations and Doctoral Studies

This Doctor of Nursing Practice (DNP) project addressed a critical knowledge gap among clinical staff regarding the application of Social Determinants of Health (SDOH) within a local health department. Although SDOH screening tools and the statewide NCCARE 360 referral system were in place, inconsistent use hindered integration into patient care and limited efforts to advance health equity. Guided by the Johns Hopkins Evidence-Based Practice model and the ADDIE instructional framework, an educational intervention was developed and implemented to enhance staff knowledge, confidence, and integration of SDOH principles into workflow. Thirty-five clinical staff members participated in pre- and post-intervention assessments. Data …


Promising Effects Of Car T-Cell Therapy In Refractory Stiff Person Syndrome And A Hopeful Future For All Neuroautoimmunities, Marinos Dalakas Nov 2025

Promising Effects Of Car T-Cell Therapy In Refractory Stiff Person Syndrome And A Hopeful Future For All Neuroautoimmunities, Marinos Dalakas

Department of Neurology Faculty Papers

Chimeric antigen receptor (CAR) T cells are genetically modified T cells expressing CARs, initially developed to recognize tumor antigens and kill cancer cells that evade T-cell recognition. Because of their impressive success in hemato-oncologic malignancies, CAR T cells are being repurposed with redesigned constructs for safety and sustained efficacy to target refractory systemic autoimmune or neurologic diseases. The CD19 CAR T cells-targeting those CD19-positive, antibody-secreting, long-lived plasma cells, and plasmablasts-are now extensively explored in refractory neuroautoimmunities with promising benefits based on case series in patients with myasthenia gravis (MG), stiff person syndrome (SPS), neuromyelitis, myositis, and multiple sclerosis; some patients …


Staff Education For Nurses To Increase Nursing Staff Knowledge On Hospital-Acquired Infection Prevention, Mimi M. Farride Nov 2025

Staff Education For Nurses To Increase Nursing Staff Knowledge On Hospital-Acquired Infection Prevention, Mimi M. Farride

Walden Dissertations and Doctoral Studies

This Doctor of Nursing Practice (DNP) project focused on a staff education initiative aimed at reducing hospital-acquired infections (HAIs) in healthcare settings. HAIs contribute to patient morbidity, extended hospital stays, and increased healthcare costs. Despite established infection control policies, inconsistencies in adherence had highlighted the need for targeted education. The central practice question guiding this project, conducted in a hospital setting, was, “How did implementing a comprehensive infection prevention education program for healthcare staff influence their knowledge?” The primary goal was to educate staff with the skills needed to minimize infection risks and enhance patient outcomes through effective prevention techniques. …


Educating Staff On Hourly Rounding Toward Fall Prevention In A Long-Term Care Facility, Princess Aminata Kanu Nov 2025

Educating Staff On Hourly Rounding Toward Fall Prevention In A Long-Term Care Facility, Princess Aminata Kanu

Walden Dissertations and Doctoral Studies

The identified problem at the project site facility was rising incidences of patient falls, which was attributed to insufficient staff knowledge of evidence-based strategies for preventing falls, including purposeful hourly rounding (PHR). Research has demonstrated that PHR effectively reduces the risk of falls among patients by allowing clinicians to proactively address patient needs. The purpose of this staff education project was to enhance healthcare providers’ knowledge of PHR and its role in fall prevention. The practice-focused question that guided this project was: For staff in a long-term care facility, will training on hourly rounding increase knowledge toward the goal of …


Staff Education For Catheter-Related Urinary Tract Infection Prevention In Intensive Care, Ascar Boinett Nov 2025

Staff Education For Catheter-Related Urinary Tract Infection Prevention In Intensive Care, Ascar Boinett

Walden Dissertations and Doctoral Studies

This doctor of nursing practice (DNP) staff education project was conducted to address inconsistent adherence to catheter-associated urinary tract infection (CAUTI) prevention bundles in an adult intensive care unit (ICU). CAUTIs remain a leading cause of morbidity, extended hospital stays, and increased healthcare costs. The project aimed to improve nurses’ knowledge and attitudes regarding CAUTI prevention through structured education and the integration of daily catheter reassessment checklists into practice. A quantitative pretest–posttest design was used to measure changes in participants’ knowledge and attitudes following two 45-minute educational sessions. Forty-two ICU nurses participated in the intervention. Data were analyzed using descriptive …


Family Caregivers' Perspectives On Challenges And Support Needs In Hospital-Based Palliative Care For Persons Living With Dementia, Jung Kwak, Anita Chary, Sarah Stayer, Kwaku Duah Oppong, Sumin Yoon, Snehal Patel, Elizabeth A Kvale Nov 2025

Family Caregivers' Perspectives On Challenges And Support Needs In Hospital-Based Palliative Care For Persons Living With Dementia, Jung Kwak, Anita Chary, Sarah Stayer, Kwaku Duah Oppong, Sumin Yoon, Snehal Patel, Elizabeth A Kvale

Faculty, Staff and Students Publications

Palliative care needs of hospitalized persons living with dementia (PLWD) and their family caregivers remain poorly understood. This mixed-methods study explored caregivers' perspectives on challenges and support needs when hospitalized PLWD received specialist palliative care consultations. Thirty-two caregivers were recruited from two hospitals; 18 completed interviews and surveys, and 14 completed surveys only. Participants were racially and ethnically diverse (19% Black or African American, 34% Latino or Hispanic). Most identified as women (65%) and adult children (56%). Commonly reported challenges included managing health issues (59%), emotional distress (56%), and decision-making (47%). Thematic analysis of interviews revealed three themes: the value …


Tlr2 Agonism Suppresses Myeloid Leukemogenesis By Reprogramming Leukemia Stem Cells, Michael E. Lawler, Jennifer S. Romer-Seibert, Michael S. Bowman, Ramkrishna Mitra, Christine M. Eischen, Robert L. Bowman, Sara E. Meyer Nov 2025

Tlr2 Agonism Suppresses Myeloid Leukemogenesis By Reprogramming Leukemia Stem Cells, Michael E. Lawler, Jennifer S. Romer-Seibert, Michael S. Bowman, Ramkrishna Mitra, Christine M. Eischen, Robert L. Bowman, Sara E. Meyer

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

The consequences of activated innate immune signaling in acute myeloid leukemia (AML) is not well understood. Using ligands directed at the toll-like family receptors (TLR) in models of high-risk AML, we uncover that TLR2 ligands exert unique antileukemic effects that are distinct from other TLRs. Although TLR2 signaling broadly induces inflammatory gene expression in AML cells, at the single-cell level, cell-type-dependent, divergent transcriptional responses coordinate cellular outputs of proliferation, differentiation, cell death, and activation of immune cell function. TLR2 ligands were the only TLR agonists capable of extending survival of AML-bearing mice through leukemia stem cell (LSC) reprogramming that elevated …


Use Of Calcium Modification In Percutaneous Coronary Intervention: A Comprehensive Review, Noyan Ramazani, Ala W. Abdallah, Michael V. Dicaro, Divyansh Sharma, Aditi Singh, Kachon Lei Nov 2025

Use Of Calcium Modification In Percutaneous Coronary Intervention: A Comprehensive Review, Noyan Ramazani, Ala W. Abdallah, Michael V. Dicaro, Divyansh Sharma, Aditi Singh, Kachon Lei

Department of Internal Medicine Faculty Research

Calcified coronary lesions remain a challenge in percutaneous coronary intervention (PCI) in both situations of acute myocardial infarction (MI) and stable coronary syndrome. It significantly increases the risk of procedural complications due to difficulty in equipment delivery, balloon expansion, and stent delivery. Furthermore, stent thrombosis, dissection, perforation, and future in-stent restenosis occur more frequently in calcified coronary lesions, impacting repeat target vessel revascularization and increasing the risk of future MI. With intracoronary imaging (intravascular ultrasound and optical coherence tomography), peri-procedural success for treating calcified lesions has increased significantly. Different modalities of calcium modification techniques have since been introduced. This review …