Medicine and Health Sciences Commons^™

Profiling Tumour-Infiltrating Immune Cells In A Large Paediatric Medulloblastoma Cohort: A Retrospective Analysis, Mingze Chen, Xiangjun Shi, Yi Wang, Jiao Zhang, Jirong Guo, Xiuchen Guan, Yu Sun, Wenhao Wu, Chunde Li, Yongji Tian, Yunwei Ou, Tian Li, Kai Jiang, Michael D Taylor, Xuebin Liao, Liwei Zhang, Tao Sun

Faculty, Staff and Students Publications

Background: Tumour-infiltrating immune cells exert both pro-tumour and anti-tumour effects on intracranial tumours. In this study, we investigated the prognostic value of various infiltrating immune cells in medulloblastoma (MB) within a large cohort.

Methods: We employed multiplex immunofluorescent (mIF) staining of tissue microarrays to assess the densities of T cells, B cells, NK cells, macrophages, and immune checkpoints in tumour samples from 249 primary paediatric patients with primary MB. Overall survival (OS) analysis, progression-free survival (PFS), and Cox regression analyses were utilised to explore potential relationships between immune cell densities and survival outcomes. Subsequently, multivariate Cox regression was validated using …

2025 - The Sixth Annual Fall Symposium Of Student Scholars

Symposium of Student Scholars Program Books

The full program book from the Fall 2025 Symposium of Student Scholars, held in November 2025. Includes abstracts from the presentations and posters.

Factfinders For Patient Safety: Minimizing Complications In Radiofrequency Neurotomy: Part I-Implantable Devices; Part Ii-Preprocedural Bvnrfn Imaging, David Hao, Gerald Yeung, Haewon Lee, Zheyan Chen, Ben Laplante, Paul Kitei, Reza Ehsanian, David Levi

Moss-Magee Rehabilitation Papers

This series of FactFinders presents a brief summary of the evidence and outlines recommendations regarding minimizing risks with radiofrequency neurotomy procedures. The evidence in support of the following facts is presented: (1) While data on the safety of radiofrequency neurotomy in patients with implanted devices are limited, the procedure can likely be performed safely with careful adherence to best practices and manufacturer recommendations. (2) Basivertebral nerve radiofrequency neurotomy can be performed safely and effectively at the L3 through S1 vertebral levels. Scrutiny of preprocedural imaging may minimize risk. Although the transpedicular approach is preferred, patient anatomy may dictate a non-transpedicular …

An Experiential Learning Lab Activity On Skeletal Muscle Physiology In Undergraduate Md Pre-Clerkship Curriculum, Angela Martinez, Daniel Salinas, Meyer Maddox, Kelsey A. Potter-Baker, Amin Shah

School of Medicine Publications

Experiential learning is an important part of the medical education curriculum. Due to clinical relevance of skeletal muscle strength in evaluating patients’ complaints of muscle weakness or imbalance, skeletal muscle physiology is an important concept with extensive potential for experiential learning opportunities. Our goal was to establish an experiential learning skeletal muscle physiology lab activity that would improve undergraduate MD pre-clerkship students’ skill to collect muscle force measurements using a hand-held dynamometer (HHD) and expand knowledge of core physiological concepts. We developed a muscle lab activity where students performed two experiments using an HHD: (1) The Elbow Flexion Experiment and …

The Differential Effects Of Camp Mobilizing Agents On Tgf-Β-Induced Extracellular Matrix In Human Lung-Derived Fibroblasts: Insights Into Therapeutic Targets For Lung Fibrosis, Sarah Orfanos, Brian T. Deeney, Gaoyuan Cao, Nikhil Karmacharya, Anjani Ravi, Cynthia J. Koziol-White, Qi Yang, Rennolds S. Ostrom, Reynold A. Panettieri Jr.

Pharmacy Faculty Articles and Research

Background

Injury-repair responses typically induce tissue or organ scarring. Generally, cAMP-mobilizing agents inhibit the activation of fibroblasts and deposition of extracellular matrix. Some but not all cAMP-mobilizing agents inhibit fibrosis. Evidence suggests that inhaled treprostinil, a prostacyclin (IP) analog, increases intracellular cAMP levels [cAMP]I, and slows the decline in pulmonary function in patients with idiopathic pulmonary fibrosis (IPF). However, the molecular mechanisms by which cAMP-mobilizing agents, including treprostinil, alter the expression of matrix proteins in human lung fibroblasts (HLF) remain unclear. Unlike other Gαs -coupled receptors, we posit that the antifibrotic properties of treprostinil are driven by cAMP-mobilizing-dependent and -independent …

Traumatic Fracture Of Kager's Fat Pad: A Case Report., Victoria Di Castro Horn, Margaret Hurley, Emily Andrews, Alberto Giardini

PCOM Scholarly Works

BACKGROUND: Kager's fat pad is a metabolically active adipose structure within Kager's triangle anterior to the Achilles tendon, involved in shock absorption, vascular support, and tendon lubrication. Although most research has focused on its role in Achilles tendinopathy and inflammatory conditions, isolated traumatic disruption without concurrent tendon damage has been rarely documented in the literature, to our knowledge. We report a case of an isolated traumatic fracture of the Kager's fat pad in the absence of concomitant Achilles tendon injury.

CASE PRESENTATION: An otherwise healthy 31 year-old female presented to the outpatient musculoskeletal office with reported pain at the distal …

An Essay On Trailblazing With Service Animals Langer, Pilot, Bowie, And Izzie: Preserving Non-Partisan Public Health And The Law, Gary C. Norman

Journal of Law and Health

A direct correlation exists among humans, their animals, and human health and wellness. This article will focus concisely on law students with disabilities and lawyers with disabilities and how they can be empowered to be trailblazers while remaining healthy and well. Salutogenic Model should be optimized by lawyers with disabilities working at the intersection of animal law, disability law, and public health law. Service animals have positive and salubrious impacts upon their handlers in several ways, including psychosocial health and wellbeing. The Grand Architect (or in my Cherokee tradition, "great spirit") continuously partners me with complicated but magnificent dog partners …

At1-Aa Induced Hypertension During Pregnancy Contributes To Developmental Programming Of Hypertension In Female Offspring, Nathan Campbell, James P. Lemon, Melissa Helmich, Dylan Solise, Alexandra Demesa, Ella Goolsby, Evan Lamarca, Evangeline Deer, Denise C. Cornelius, Ty Turner, Lorena M. Amaral, Baoying Zheng, Babbette Lamarca

Pharmacology and Toxicology

Preeclampsia (PE), new-onset hypertension during pregnancy, is accompanied by organ dysfunction, in addition to placental dysfunction, and is associated with chronic inflammation and fetal growth restriction. Agonistic autoantibodies against the angiotensin II type 1 receptor (AT1-AA) are produced in PE women and induce a PE-like phenotype when infused into pregnant rats. PE offspring are at higher risk for cardiovascular disease and hypertension; however, AT1-AA’s role in these risks is unknown. Therefore, we hypothesized that AT1-AA exposure during pregnancy contributes to hypertension in adult offspring. We infused AT1-AA (1:40) starting on gestational day (GD) 14, allowed the dams to give birth, …

Evaluating The Effectiveness Of Clinical Practice Guideline Adherence For Patellofemoral Pain (Knee-Capp): Protocol For A Multisite, Parallel-Arm Randomized Clinical Trial In The Military Health System, Emma H. Beisheim-Ryan, Timothy C. Mauntel, Daniel I. Rhon, Charity G. Patterson, Nathan Parsons, Scott Paradise, Megan H. Roach, Marisa Pontillo, Sara R. Gorczynski, Ariana Emory, Shawn Farrokhi

Physical Therapy Faculty Articles and Research

Importance

Patellofemoral pain (PFP) frequently affects military personnel, caused by the physical demands of duty-related training. Clinical practice guidelines (CPG) can guide PFP management, yet physical therapist practice patterns vary and often exclude CPG-recommended, evidence-based interventions. Objective

The Evaluating the Effectiveness of Clinical practice guideline Adherence for Patellofemoral Pain (knEE-CAPP) trial assesses whether a CPG-adherent physical therapy approach more significantly reduces pain, disability, health care utilization, and analgesic medication prescription in Service members with PFP as compared to usual physical therapist care. Design

This is a multisite, parallel arm randomized controlled trial. Setting

The study will be conducted at 4 …

Bilateral Concomitant Infection Of Cytomegalovirus And Varicella-Zoster Virus Retinitis In An Immunocompromised Adult, Henry C Skrehot, Amer Alsoudi, Daniel Olson, Nhon Le, Asad Loya, Tahira Scholle

Faculty, Staff and Students Publications

Purpose: To report a novel case of bilateral concomitant cytomegalovirus (CMV) retinitis and acute retinal necrosis (ARN) due to varicella-zoster virus (VZV) in an immunocompromised adult.

Methods: A case report was evaluated.

Results: A 36-year-old immunocompromised man presented with acute painful vision loss in the left eye. On initial presentation, uncorrected distance visual acuity was 20/20 in the right eye and counting fingers at 3 feet (≈1 m), which deteriorated to no light perception (NLP) in the left eye. Fundus examination showed necrotizing retinitis in both eyes, with features of both CMV retinitis and ARN. One week after initiation of …

Divergent Prefrontal Cortex Circuits Regulate Cued Food Seeking Under Distinct Metabolic Or Emotional States, Xu O Zhang, Guillermo Aquino-Miranda, Claire E Cho, Yongzhe Wang, Duy Hoang Ha, Nikita Elinson-Watson, Allen Dong, Caleb Kemere, Fabricio H Do-Monte

Faculty, Staff and Student Publications

Flexibly adjusting food-seeking behaviour in response to food-associated cues and internal states is crucial for animals' survival. However, the neural mechanisms that modulate cued food-seeking behaviour during varying metabolic (i.e., hungry vs. satiated) and emotional (i.e., safe vs. threatened) states remain elusive. Here, we show that the encoding of metabolic or threat states in projection-defined neurons in the prelimbic cortex (PL) mediates cued food-seeking responses in rats. Using microendoscopic imaging, we demonstrate that neural population dynamics in PL consistently represent food cues, task-relevant behaviours, and internal state changes by recruiting distinct subsets of cue-responsive neurons at each state. Single-unit recording …

Interventions To Enhance Care Partner Performance And Participation In Alzheimer's And Neurocognitive Disorders: A Systematized Review, Ainslie Suyko, Addison Werner, Elizabeth A. Stacy, Danielle M. Westmark, Stacy Smallfield, Molly A. Whitlow

Student Systematized Reviews: Occupational Therapy

Purpose: Care partners of people with Alzheimer’s disease (AD) and related neurocognitive disorders (NCDs) often experience disrupted routines, reduced self-care, and limited participation in meaningful occupations. Occupational therapy (OT) supports care partners’ engagement in health-promoting activities and sustainable caregiving (Rhodus et al., 2023). This systematized review examined interventions that enhance care partner performance and participation.

Design: Peer-reviewed, English-language articles were included if they involved adult care partners of individuals with AD or NCDs, implemented an intervention within the scope of OT, and used quantitate research designs.

Method: A total of 319 articles from MEDLINE, CINAHL, and Scopus were screened; 61 …

Multidomain Therapy For Alzheimer's Disease: A Scoping Review Of Cognitive Decline Trials, Jared C Roach, Cyrus A Raji, Et Al.

2020-Current year OA Pubs

BACKGROUND: Alzheimer’s disease (AD) leading to cognitive decline and dementia results from the interplay of multiple interacting dysfunctional biological systems. These systems can be categorized by domain, such as inflammation, cardiovascular health, proteostasis, or metabolism. Specific causes of AD differ between individuals, but each individual is likely to have causes stemming from multiple domains. Personalized multidomain therapy has been proposed as a standard of care for AD. OBJECTIVES: We sought to enumerate and describe prospective randomized controlled trials (RCTs) for multidomain interventions for AD, and to extract their inclusion criteria, trial design parameters (length, number of participants), and outcome measures. …

The Art Of The Review: A 9-Step Guide For Beginning Researchers, Sandra Y. Desjardins, Jenny Stockton

Library Class: Lunch & Learn

Master the systematic review process from start to finish. This 30-minute course provides a comprehensive overview of nine essential steps. Learn how to plan, execute, and report on your systematic review with confidence.

A Conversation With Dr. Shannon Jones Faculty Highlight, Paxton Mills

Osmosis Magazine

Dr. Shannon Jones, Senior Teaching Faculty in the Department of Biology, is a toxicology expert, teacher, and long-time mentor from Roper, North Carolina. With a PhD in Toxicology from the University of North Carolina at Chapel Hill, Dr. Jones came to the University of Richmond with a purpose: to transform the lives of her students.

Computer Problems? Must Have Been The Sun How Solar Particles And Cosmic Rays Affect The Future Of Computing, Ned Markham

Osmosis Magazine

Imagine playing your favorite video game, when suddenly, your character teleports to the top of the level. One may be quick to blame the software for faulty code, clueless that this error may have originated from an unlikely source: the sun. That’s right, during a speed run of Nintendo’s Super Mario 64, one stray cosmic ray flipped a single bit (a bit is the most basic unit of information inside a computer, storing one of only two possible values of 0 and 1), causing a streamer’s character to glitch in front of him and a live audience. This phenomenon, however, …

A Journey Into The Mysterious Quantum Realm, Kien Bui

Osmosis Magazine

Toward the end of the 18th century, many scientists believed that all the fundamental laws of physics had already been discovered. Falling apples obeyed Newton’s laws of motion, spinning compasses were explained by Maxwell’s unification of electricity and magnetism, and steam engines drove the first industrial revolution through the rise of thermodynamics. Lord Kelvin stated, “[t]here is nothing new to be discovered in physics now, all that remains is more and more precise measurement.” Only “two small clouds,” he warned, were the two remaining mysteries: black-body radiation and the theory of light. These small clouds, however, turned out to be …

From Sci-Fi To Reality: Could There Be Life On Mars?, Matea Šarkinović

Osmosis Magazine

Have you ever wondered: Are we alone in the universe? Well, scientists hope to answer the age-old question and they believe that Mars could hold the answer. The red planet has been identified as a potential home to life beyond Earth, and this article aims to explore what makes Mars such a strong candidate. Understanding the conditions on extraterrestrial objects is key to determining if our existence is a unique phenomenon or if we are the product of a recurring event that happens throughout the universe.

My Roman Empire: The Mystery Of Roman Concrete, Lilly Cashen

Osmosis Magazine

After the fall of an empire and millennia of conflict and decay, most structures crumble. Yet the monumental dome of the Pantheon, the towering ruins of the Colosseum, and the sprawling miles of aqueducts still stand today, two thousand years later, as testaments to Roman engineering brilliance. The survival of these ancient structures was made possible by one of Rome’s greatest innovations: Roman concrete, or opus caementicium.

True Silver: A Story Of Skin Coining With Silver In Traditional Asian Medical Practice, Trang Nguyen

Osmosis Magazine

Silver, one of the most precious metals on Earth, has captivated humans since prehistoric times for its natural shimmer, which has found its way into coins, jewelry, and ornaments (The Natural Sapphire Company, 2025). In traditional Asian medicine, silver’s significance extends beyond jewelry or currency; it is a key component in a practice called “cạo gió”, which involves releasing energy blockages and restoring balance to the body using a smooth metal tool to scrape the skin. Although it has been passed down through generations as a remedy for various ailments, a question remains: what makes silver the material of choice?

A Tragic Love Story Neanderthal-Human Interbreeding, Parth Patel

Osmosis Magazine

Humans moved northward when it became too hot and arid. Before that, we spent a few hundred thousand years evolving to the conditions of Africa (Hajdinjak et al., 2018). Our bones, genes, and skills were all honed to ensure survival in a particular climate, so when that climate began to change, the evolutionary traits that developed through years of mutations suddenly became deficient. It forced us to move in droves to Western Eurasia, where we found some comfort in the cooler weather (Slimak et al., 2024). We also found another species of human: the Neanderthal.

Spicomellus The Jurassic Enigma, Bryan Nam

Osmosis Magazine

Imagine stepping into a time machine and messing with the controls until you find someplace interesting to go. Your destination? Morocco, 165 million years ago. You arrive and look around at vast floodplains stretching far across the horizon; flat land cut through by mighty rivers. In the distance, you see something, a creature unlike any you’ve ever seen before. It looks straight out of a sci-fi movie. It seems almost like a reptilian tank, with huge spikes on its neck and hips. The dinosaur looks towards you, then turns away to look for food. You have just come face to …

Let’S Talk About Birds Baby: How Did Birds Evolve To Have Such Elaborate Courtship Rituals?, Lautaro Lo Prete

Osmosis Magazine

If you’ve ever watched a nature documentary featuring David Attenborough, you’ve definitely marveled at the eccentric and complex rituals of some bird’s courtship display. This behavior is a phenomenon among birds where males will often complete a ritualistic dance as a way to attract a female. But why go through all the hassle? What is the purpose of expending so much energy— all the while putting yourself at such a heightened risk of predation?

Does Free Food Lead To Less Food? Dependency Theory & The Ambiguous Effects Of Food Aid, Stevi Dugas

Osmosis Magazine

Dependency Theory, in the context of food aid, holds that food aid and subsequent increases in food supply disincentivize local agricultural production, resulting in local dependence on food aid for survival. But, is this actually the case? This article first explains the economic theory behind Dependency Theory, then examines why this theory may not connect to reality and some strategies for remedying the flaws of modern non-emergency food aid to ensure effective humanitarian aid.

From Convenience To Consequence The Health Risks Of Eating Ultraprocessed Food, Eve Snyder

Osmosis Magazine

Understanding Ultraprocessed Foods and Their Effects on the Body What happens to the body when it's deprived of vital nutrients from fiber and protein, and pumped full of excessive sugar, fats, and salt? This situation can happen by eating ultraprocessed foods. Ultraprocessed foods are made with processes you wouldn't normally perform in a home kitchen, with ingredients that have little, if any, nutritional value. Pumped with additives to enhance color and taste, ultraprocessed foods may look appealing, but they can have harmful, longterm health risks (Monteiro et al., 2019).

Mushrooms And Mind Control, Connor Beasley

Osmosis Magazine

In a humid forest climbs a lone carpenter ant. At midday, it sinks its mandibles into a leaf’s vein and is locked in place. A few days later, a thin stalk of mycelium erupts from its head, dusting the forest floor in spores to infect a new victim. The ant has been infected by an unseen puppeteer known as Ophiocordyceps unilateralis sensu lato, more commonly called cordyceps or the “zombie‑ant fungus” (de Bekker et al., 2021). When we think of mind control, visions of mad scientists and maniacal villains tend to dance through our heads; the true culprits, however, are …

Chew On This How Gum Can Prevent Cavities, Garrett Mayover

Osmosis Magazine

Gum has become a staple in my daily routine. What started as something I chewed casually after school has evolved into a small yet essential part of how I relax, focus, and stay alert throughout the day. Beyond its familiar chewy texture and refreshing flavors, gum has a surprising hidden benefit - it can actually help prevent cavities. This article will explore what gum really is, the science behind its cavity-fighting abilities, and which types of gum are best for maintaining a healthy smile.

Red Flags Are My Favorite Color: The Psychology Of Falling For The 'Bad Boys', Erlinda Sali

Osmosis Magazine

The “bad boy” has been a recurring figure in popular culture for years. He’s the leather-jacketed brooding rebel, the dangerous lover, the tortured antihero that we have learned to romanticize. This archetype blends “juvenile masculinities (aggression, rebellion, hypersexuality)” with appealing qualities like “charisma, ruggedness, and sensitivity,” creating a moral ambiguity that captivates audiences (Gopaldas and Molander, 2019). This contradictory mix keeps him popular across movies, songs, and advertisements. But with this archetype being ‘a walking red flag,’ why are we still so bewitched by the bad boy, and should we be?

Trouble-Making Teens: Can They Control Their Impulses?, Natasha Troike

Osmosis Magazine

Teenagers can be moody, irritable, and defiant; they may snap at their parents and make risky decisions that they regret. Decisions such as having unprotected sex or taking harmful, illegal substances can be drastically life-changing. Are these risky decisions acts of purposeful defiance, or is there more to it? Are teens truly in charge of their impulses, or are they victims of their developmental biology?

To Q-Tip Or Not To Q-Tip, Ainsley Coleman

Osmosis Magazine

If you are one of the many people on this earth lucky enough to have wet earwax and use earbuds, you have likely experienced some sort of discomfort at some point in your ears. Maybe it’s a slight itch, or a feeling of build-up, and so you reach for a q-tip. And, maybe as you reach for that cotton swab, you feel nagged by a reminder that q-tips are not to be put in your ears! But still, you use one to relieve that discomfort.