Medicine and Health Sciences Commons^™

Psychiatric Service Dogs: Use And Value For Military Veterans With Ptsd, Catherine Ephlin

The Journal of Purdue Undergraduate Research

No abstract provided.

Analysis Of Manganese Accumulation In The Pituitary Gland And Hippocampus Of Smelters Using High Resolution 3-D T1-Weighted Mri, Alison Jeffries, Zeinab Aly, Molly Cromer

The Journal of Purdue Undergraduate Research

No abstract provided.

Developing Drug Therapies: Cognitive Damage In Mice Following Brain Radiation, Rachel Yuska

The Journal of Purdue Undergraduate Research

Pediatric brain cancer patients are at a high risk for radiation-induced cognitive impairment due to white matter changes in the brain. Half of six-month radiotherapy survivors develop significant changes in white matter. Previous research has shown that a mouse model can be used to show similar cognitive and behavioral deficits in human patients. The purpose of this work is to evaluate the effectiveness of two drug therapies, Donepezil and 3,3-Diindolylmethane (DIM), that could be used to either protect the brain from radiation injury or cure the cognitive injury and behavioral deficits that result from whole-brain irradiation. This project consisted of …

Nanomaterial-Agrichemical Interactions: Association Of Environmental Herbicides With Two-Dimensional Graphene Nanoplatelets, Nudar A. Bhuiya

The Journal of Purdue Undergraduate Research

Atrazine and glyphosate are the two most common agricultural herbicides used in the United States. Both herbicides can move in the environment, which results in contamination of drinking water sources. Graphene nanoplatelets (GNPs) are an emerging nanoparticle with potential uses for the remediation of environmental contamination. The first aim of this study was to determine binding interactions between atrazine and GNPs to mimic a mixture composition. To determine binding interactions, GNPs with different functional groups (none, carboxylated, or aminylated) were evaluated. GNPs at concentrations of 0, 0.5, 1, 2, or 3 mg/ml were incubated with atrazine at 3 ppb (μg/L) …

Data Analytics For Healthcare Management Mhm 508, Joanna Burkhardt

Library Impact Statements

No abstract provided.

Measures Of Fluid Loss During Surfing: A Preliminary Analysis In Recreational Surfers, Rudi A. Meir, Zachary James Crowley-Mchattan Dr, Lyndon O. Brooks, Blake Duncan, Christian Gorrie, Jeremy Sheppard

International Journal of Aquatic Research and Education

Surfing is a popular sport, but little is known about the extent to which recreational surfers experience fluid loss from this activity. The principal objective of this research was to estimate fluid loss during a surfing session through changes in pre- to post-session urine color (Ucol), urine osmolality (Uosm), and body mass (BM). Data were collected from 11 recreational surfers across 14 surf sessions conducted under various environmental (mean water temperature = 22.1 SD ± 2.3; range = 20-26^oC; air temperature range = 13.1-31.5^oC; relative humidity range = 37.5-88.1%) and surfing conditions (e.g. winter/summer, wave type, …

From Treading Water To Swimming Uphill: A Comprehensive And Innovative Assessment Program For Teaching Swimming In Belgian Primary Schools., Filip Roelandt

International Journal of Aquatic Research and Education

According to the World Health Organization (WHO), every child should learn to swim as a recognised life skill. Which swimming skill or stroke to learn first is not the most important question. What is important is to teach children to learn tasks or techniques which allow them to they feel safe. Emphasizing foundational principles of motor development and focusing on safety in and around the water are paramount. Beginning in 2016 school swimming lessons in Flanders (Belgium) were given a new focus in all educational institutions. Foundational competence tasks replaced the focus on acquiring competitive swimming strokes as the primary …

Stem Opportunities - High School 2019, Huey-Xian Kelly Wong, Madeleine Rauhauser, Annie Morgan Nelson

Honors Program: Expanded Learning Clubs

This publication details the lesson plan for the “Opportunities in STEM” club for the summer of 2019. This club began out of a desire to educate high school students about the opportunities and careers available in the science, technology, engineering, and mathematics fields. Often, students feel that the prospect of entering a STEM field is daunting and out of their grasp. What it means to be a scientist is often unclear, and students never consider opportunities out of the fear of the unknown, particularly when science is associated with complexity and difficulty. This lesson plan integrates experiments with a wealth …

Economics For Healthcare Management Mhm 504, Andree Rathemacher

Library Impact Statements

No abstract provided.

Head Depth And Head Speed During Competitive Backstroke Ledge Starts, Wesley J. Manz, Joel T. Greenshields, Brian V. Wright, Curtis S. Goss, Benjamin C. Skutnik, Joel M. Stager

International Journal of Aquatic Research and Education

Recently, a commercially available starting ‘ledge’ designed to reduce foot slippage during the execution of the backstroke start was introduced in competitive swimming. For the purpose of identifying potential safety consequences, the present study investigated the effect of ledge use on head depths, speeds, and distances in backstroke starts of athletes with no prior or only novice familiarity of the ledge. Competitive backstroke starts were performed with and without ledges by high school-aged (14.5 to 19.2 yr, N = 61) swimmers in 1.52 m of water during a closed testing session. A SIMI Reality Motion System in a calibrated space …

Response Of Human Small Intestinal Epithelium To Fractionated Irradiation: Dynamical Modeling Approach, Francis A. Cucinotta, Olga A. Smirnova

Health Physics and Diagnostic Sciences Faculty Research

A biologically motivated mathematical model of the dynamics of the small intestinal epithelium in humans treated with fractionated radiotherapy has been developed and is further investigated here. This model, originating from our previous work, is implemented as a system of nonlinear ordinary differential equations, in which the variables and parameters have a clear biological meaning. The model also includes, as input, the key parameters of fractionated irradiation. The modeling results on the dynamical response of the human normal small intestinal epithelium to fractionated radiation therapy regimens were in agreement with the corresponding empirical data, which, in turn, demonstrates the capability …

Meta-Analysis Of Cognitive Performance By Novel Object Recognition After Proton And Heavy Ion Exposures, Eliedonna Cacao, Francis A. Cucinotta

Health Physics and Diagnostic Sciences Faculty Research

Experimental studies of cognitive detriments in mice and rats after proton and heavy ion exposures have been performed by several laboratories to investigate possible risks to astronauts exposed to cosmic rays in space travel and patients treated for brain cancers with proton and carbon beams in Hadron therapy. However, distinct radiation types and doses, cognitive tests and rodent models have been used by different laboratories, while few studies have considered detailed dose-response characterizations, including estimates of relative biological effectiveness (RBE). Here we report on the first quantitative meta-analysis of the dose response for proton and heavy ion rodent studies of …

Patterns Of Treatment For Psychiatric Disorders Among Children And Adolesecents In Mississippi Medicaid, John Young, Sujith Ramachandran, Andrew J. Freeman, John P. Bentley, Benjamin F. Banahan

Psychology Faculty Research

The nature of services for psychiatric disorders in public health systems has been understudied, particularly with regard to frequency, duration, and costs. The current study examines patterns of service reception and costs among Medicaid-covered youth newly diagnosed with anxiety, depression, or behavioral disturbance in a large data set of provider billing claims submitted between 2015–2016. Eligibility criteria included: 1) identification of an initial diagnosis of a single anxiety, unipolar mood, or specific behavioral disorder; 2) continuous Medicaid eligibility over the duration of the time period studied; and 3) under 18 years of age on the date of initial psychiatric diagnosis. …

Advances In Gene Ontology Utilization Improve Statistical Power Of Annotation Enrichment, Eugene Waverly Hinderer Iii, Robert M. Flight, Rashmi Dubey, James N. Macleod, Hunter N. B. Moseley

Maxwell H. Gluck Equine Research Center Faculty Publications

Gene-annotation enrichment is a common method for utilizing ontology-based annotations in gene and gene-product centric knowledgebases. Effective utilization of these annotations requires inferring semantic linkages by tracing paths through edges in the ontological graph, referred to as relations. However, some relations are semantically problematic with respect to scope, necessitating their omission or modification lest erroneous term mappings occur. To address these issues, we created the Gene Ontology Categorization Suite, or GOcats—a novel tool that organizes the Gene Ontology into subgraphs representing user-defined concepts, while ensuring that all appropriate relations are congruent with respect to scoping semantics. Here, we demonstrate the …

Equine Or Porcine Synovial Fluid As A Novel Ex Vivo Model For The Study Of Bacterial Free-Floating Biofilms That Form In Human Joint Infections, Jessica M. Gilbertie, Lauren V. Schnabel, Noreen J. Hickok, Megan E. Jacob, Brian P. Conlon, Irving Shapiro, Javad Parvizi, Thomas P. Schaer

Department of Orthopaedic Surgery Faculty Papers

Bacterial invasion of synovial joints, as in infectious or septic arthritis, can be difficult to treat in both veterinary and human clinical practice. Biofilms, in the form of free-floating clumps or aggregates, are involved with the pathogenesis of infectious arthritis and periprosthetic joint infection (PJI). Infection of a joint containing an orthopedic implant can additionally complicate these infections due to the presence of adherent biofilms. Because of these biofilm phenotypes, bacteria within these infected joints show increased antimicrobial tolerance even at high antibiotic concentrations. To date, animal models of PJI or infectious arthritis have been limited to small animals such …

Patient Experience And Challenges In Group Concept Mapping For Clinical Research., Geoffrey D. Mills, Marianna Lanoue, Alexzandra T. Gentsch, Amanda M.B. Doty, Amy Cunningham, Garrison Nord, Kristin L. Rising

Department of Emergency Medicine Faculty Papers

BACKGROUND AND OBJECTIVE: Group concept mapping (GCM) is a research method that engages stakeholders in generating, structuring and representing ideas around a specific topic or question. GCM has been used with patients to answer questions related to health and disease but little is known about the patient experience as a participant in the process. This paper explores the patient experience participating in GCM as assessed with direct observation and surveys of participants.

METHODS: This is a secondary analysis performed within a larger study in which 3 GCM iterations were performed to engage patients in identifying patient-important outcomes for diabetes care. …

Multi-Dimensional Extension Of The Alternating Minimization Algorithm In X-Ray Computed Tomography, Jingwei Lu

McKelvey School of Engineering Graduate Student Theses & Dissertations

X-ray computed tomography (CT) is an important and effective tool in medical and industrial

imaging applications. The state-of-the-art methods to reconstruct CT images have had

great development but also face challenges. This dissertation derives novel algorithms to

reduce bias and metal artifacts in a wide variety of imaging modalities and increase performance

in low-dose scenarios.

The most widely available CT systems still use the single-energy CT (SECT), which is

good at showing the anatomic structure of the patient body. However, in SECT image

reconstruction, energy-related information is lost. In applications like radiation treatment

planning and dose prediction, accurate energy-related information …

Multi-Dimensional Extension Of The Alternating Minimization Algorithm In X-Ray Computed Tomography, Jingwei Lu

McKelvey School of Engineering Graduate Student Theses & Dissertations

X-ray computed tomography (CT) is an important and effective tool in medical and industrial imaging applications. The state-of-the-art methods to reconstruct CT images have had great development but also face challenges. This dissertation derives novel algorithms to reduce bias and metal artifacts in a wide variety of imaging modalities and increase performance in low-dose scenarios. The most widely available CT systems still use the single-energy CT (SECT), which is good at showing the anatomic structure of the patient body. However, in SECT image reconstruction, energy-related information is lost. In applications like radiation treatment planning and dose prediction, accurate energy-related information …

On The Fabrication And Development Of Tissue On A Chip Devices With Included Perfused Vasculatures, Usama Ismail

McKelvey School of Engineering Graduate Student Theses & Dissertations

The advent of Tissue-on-a-Chip (TiOC) devices has provided a novel way for researchers to approach biological study and drug development. As a platform that enables human in vivo conditions to be accurately replicated ex vivo, TiOC can accelerate both fundamental biological research to answer basic questions regarding tissue behavior and function (e.g., cell-cell interactions in the tumor microenvironment (TME)) and translational research that includes testing of standard and novel therapeutics. The reported work focuses on development of processes and technologies common to two classes of TiOC. The first device is a single-layer, multi-compartment microfluidic device for investigation of pancreatic …

Comparison Of The Efficacy Of Four Drug Combinations For Immobilization Of Wild Pigs, Christine K. Ellis, Morgan E. Wehtje, Lisa L. Wolfe, Peregrine L. Wolff, Clayton D. Hilton, Mark C. Fisher, Shari Green, Michael P. Glow, Joeseph M. Halseth, Michael J. Lavelle, Nathan P. Snow, Eric H. Vannatta, Jack C. Rhyan, Kurt C. Vercauteren, William R. Lance, Pauline Nol

United States Department of Agriculture Wildlife Services: Staff Publications

Field immobilization of native or invasive wild pigs (Sus scrofa) is challenging. Drug combinations commonly used often result in unsatisfactory immobilization, poor recovery, and adverse side effects, leading to unsafe handling conditions for both animals and humans. We compared four chemical immobilization combinations, medetomidine–midazolam–butorphanol (MMB), butorphanol–azaperone–medetomidine (BAM™), nalbuphine–medetomidine–azaperone (NalMed-A), and tiletamine– zolazepam–xylazine (TZX), to determine which drug combinations might provide better chemical immobilization of wild pigs. We achieved adequate immobilization with no post-recovery morbidity withMMB. Adequate immobilization was achieved with BAM™; however, we observed post-recovery morbidity. Both MMB and BAM™ produced more optimal results relative to body temperature, recovery, and …

August 2019, Randy Curry, Cindy Brooks

RURAL ROCKS

Rural Rocks, the Rural Health Network newsletter by the SWOSU College of Pharmacy

Accelerated Estimation And Permutation Inference For Ace Modeling, Xu Chen, Elia Formisano, Gabriëlla A. Blokland, Lachlan T. Strike, Katie L. Mcmahon, Greig I. De Zubicaray, Paul M. Thompson, Margaret J. Wright, Anderson M. Winkler, Tian Ge

School of Medicine Publications

There are a wealth of tools for fitting linear models at each location in the brain in neuroimaging analysis, and a wealth of genetic tools for estimating heritability for a small number of phenotypes. But there remains a need for computationally efficient neuroimaging genetic tools that can conduct analyses at the brain-wide scale. Here we present a simple method for heritability estimation on twins that replaces a variance component model-which requires iterative optimisation-with a (noniterative) linear regression model, by transforming data to squared twin-pair differences. We demonstrate that the method has comparable bias, mean squared error, false positive risk, and …

Microrna And Mrna Interactions In Induced Pluripotent Stem Cell Reprogramming Of Lymphoblastoid Cell Lines, Satish Kumar, Erika C. Espinosa, Ana C. Leandro, Joanne E. Curran, John Blangero

School of Medicine Publications

A large number of Epstein Barr virus (EBV) immortalized lymphoblastoid cell lines (LCLs) have been generated and maintained in genetic/epidemiological studies as a perpetual source of DNA and as a surrogate in vitro cell model. Recent successes in reprograming LCLs into induced pluripotent stem cells (iPSCs) has paved the way to generate more relevant in vitro disease models using this existing bioresource. However, the latent EBV infection in the LCLs make them a unique cell type by altering expression of many cellular genes and miRNAs. These EBV induced changes in the LCL miRNome and transcriptome are reversed upon reprogramming into …

Determining Known-Group Validity And Test-Retest Reliability In The Peq (Personalized Exercise Questionnaire), Isabel B. Rodrigues, Jonathan D. Adachi, Karen A. Beattie, Arthur Lau, Joy C. Macdermid

Bone and Joint Institute

© 2019 The Author(s). Background: To determine the known-group validity, a type of construct validity, and the test-retest reliability of a newly developed tool, the Personalized Exercise Questionnaire (PEQ), that assesses the barriers, facilitators, and preferences to exercise in individuals with low bone mass and osteoporosis. Methods: A comparative design was used to assess known-group validity and a test-retest design to examine the reproducibility. Ninety-five participants with low bone mass and osteoporosis were recruited from an outpatient clinic in Hamilton, Ontario. The questionnaire was administered to 95 participants at baseline and a subset of 42 participants completed the survey again …

A Mixed-Methods, Randomized Clinical Trial To Examine Feasibility Of A Mindfulness-Based Stress Management And Diabetes Risk Reduction Intervention For African Americans With Prediabetes, Cheryl L. Woods-Giscombe, Susan A. Gaylord, Yin Li, Carrie E. Brintz, Shrikant I. Bangdiwala, John B. Buse, John D. Mann, Chanee Lynch, Pamela Phillips, Sunyata Smith, Karyn Leniek, Laura Young, Saada Al-Barwani, Jeena Yoo, Keturah Faurot

Publications and Research

African Americans have disproportionately high rates of stress-related conditions, including diabetes and diabetes-related morbidity. Psychological stress may negatively influence engagement in risk-reducing lifestyle changes (physical activity and healthy eating) and stress-related physiology that increase diabetes risk. ,is study examined the feasibility of conducting a randomized trial comparing a novel mindfulness-based stress management program combined with diabetes risk-reduction education versus a conventional diabetes risk-reduction education program among African American adults with prediabetes and self-reported life stress. Participants were recruited in collaboration with community partners and randomized to the mindfulness- based diabetes risk-reduction education program for prediabetes (MPD; n = 38) or …

Factors Related To Intra-Tendinous Morphology Of Achilles Tendon In Runners, Kai-Yu Ho, Ari Baquet, Yu-Jen Chang, Lung-Chan Chien, Michelle Harty, Gregory Bashford, Kornelia Kulig

Physical Therapy Faculty Research

The purpose of this study was to determine and explore factors (age, sex, anthropometry, running and injury/pain history, tendon gross morphology, neovascularization, ankle range of motion, and ankle plantarflexor muscle endurance) related to intra-tendinous morphological alterations of the Achilles tendon in runners. An intra-tendinous morphological change was defined as collagen fiber disorganization detected by a low peak spatial frequency radius (PSFR) obtained from spatial frequency analysis (SFA) techniques in sonography. Ninety-one runners (53 males and 38 females; 37.9 ± 11.6 years) with 8.8 ± 7.3 years of running experience participated. Height, weight, and waist and hip circumferences were recorded. Participants …

Design And Architecture Of An Ontology-Driven Dialogue System For Hpv Vaccine Counseling, Amith Faheem Muhammad

Dissertations and Theses (Open Access)

Speech and conversational technologies are increasingly being used by consumers, with the inevitability that one day they will be integrated in health care. Where this technology could be of service is in patient-provider communication, specifically for communicating the risks and benefits of vaccines. Human papillomavirus (HPV) vaccine, in particular, is a vaccine that inoculates individuals from certain HPV viruses responsible for adulthood cancers - cervical, head and neck cancers, etc. My research focuses on the architecture and development of speech-enabled conversational agent that relies on series of consumer-centric health ontologies and the technology that utilizes these ontologies. Ontologies are computable …

Designing High-Quality Implementation Research: Development, Application, Feasibility And Preliminary Evaluation Of The Implementation Science Research Development (Impres) Tool And Guide, Louise Hull, Lucy Goulding, Zarnie Khadjesari, Rachel E. Davis, Andy Healey, Ioannis Bakolis, Nick Sevdalis

Faculty Publications

BACKGROUND: Designing implementation research can be a complex and daunting task, especially for applied health researchers who have not received specialist training in implementation science. We developed the Implementation Science Research Development (ImpRes) tool and supplementary guide to address this challenge and provide researchers with a systematic approach to designing implementation research. METHODS: A multi-method and multi-stage approach was employed. An international, multidisciplinary expert panel engaged in an iterative brainstorming and consensus-building process to generate core domains of the ImpRes tool, representing core implementation science principles and concepts that researchers should consider when designing implementation research. Simultaneously, an iterative process …

Ewing Kauffman, Friend Of Kcu, Robyn Oro

Notes from the Archives

No abstract provided.

Laboratory Animal Welfare And Human Attitudes: A Cross-Sectional Survey On Heterospecific Play Or “Rat Tickling”, Megan R. Lafollette, Sylvie Cloutier, Colleen Brady, Brianna N. Gaskill, Marguerite E. O'Haire

Purdue University Libraries Open Access Publishing Fund

Introduction

Laboratory rat welfare is critically influenced by laboratory animal personnel through their implementation, or lack of implementation, of various enrichment techniques. One such promising technique is heterospecific play, or “rat tickling”, which mimics aspects of rat rough-and-tumble play and can contribute to improving welfare, but may be infrequently implemented. The theory of planned behavior can be used to study implementation by measuring intentions and beliefs about rat tickling, including behavioral attitudes (whether it is good or bad), subjective norms (whether there is social/professional pressure to provide it), and control beliefs (whether they feel in control of providing it). Therefore, …