Medicine and Health Sciences Commons^™

Rehabilitation Modifications For A Patient With Parkinson’S Disease Following A Suspected Case Of Gilbert’S Syndrome: A Case Study, Jason Bandong, Hy Ia, Naureen Imam, Kayla Wilcox, Travis Dennis

San Marcos, Summer 2019

The purpose of this case study was to assess the effects of core stabilization exercises, balance training, agility ladder step drills, fine motor, and dual-task training in the treatment of a high-functioning, 55-year-old, male patient with a history of Parkinson’s Disease and suspected Gilbert’s Syndrome.

This treatment program delivered for 1 hour once per week over 4 weeks led to mild improvements in activity limitations with the most notable being able to button a shirt with decreased time and assistance. The patient also exhibited mild improvement in body structure/function impairments with decreased loss of balance as evident during tandem walking …

The Power Of Pharmacist-To-Pharmacist Handoffs During Transitions Of Care, Jessica Wooster, Laressa Bethishou

Pharmacy Faculty Articles and Research

"Hospital readmissions are often medication-related and potentially preventable. Pharmacists can play a vital role in improving medication outcomes during transitions of care (TOC). Although numerous TOC practice models have been described, it remains unclear what practices will promote optimal continuity of care."

Organic Food Health Benefits Have Been Hard To Assess, But That Could Change, Cynthia Curl

Public and Population Health Faculty Publications and Presentations

“Organic” is more than just a passing fad. Organic food sales totaled a record US$45.2 billion in 2017, making it one of the fastest-growing segments of American agriculture. While a small number of studies have shown associations between organic food consumption and decreased incidence of disease, no studies to date have been designed to answer the question of whether organic food consumption causes an improvement in health.

I’m an environmental health scientist who has spent over 20 years studying pesticide exposures in human populations. Last month, my research group published a small study that I believe suggests a path forward …

Postural Orthostatic Tachycardia Syndrome (Pots): A Primer For Nurse Practitioner Practice, Emily Richards

Student Works

Postural orthostatic tachycardia syndrome (POTS) is a form of orthostatic intolerance (OI) that affects 0.2% of the population and is over-represented in women of childbearing age. It is caused by autonomic dysfunction and hypovolemia that presents with marked tachycardia and with minimal change in blood pressure upon standing. Orthostatic symptoms must be present including: lightheadedness, nausea, chest pain, palpitations, shortness of breath, and nausea and must improve with recumbence. The three main subtypes of POTS are neuropathic POTS associated destruction of peripheral nerves and venous pooling, hypovolemic POTS associated with low blood volume, and hyperadrenergic POTS associated with inappropriate sympathetic …

Burden Of Disease In Pediatric Patients With Hypophosphatasia: Results From The Hpp Impact Patient Survey And The Hpp Outcomes Study Telephone Interview., Eric T. Rush, Scott Moseley, Anna Petryk

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Hypophosphatasia (HPP) is a rare, inherited, metabolic bone disease caused by deficient tissue-non-specific isoenzyme of alkaline phosphatase activity that manifests as a broad range of signs/symptoms, including bone mineralization defects and systemic complications. The burden of disease is poorly characterized, particularly in children. This study aimed to characterize the patient-reported burden of disease among children with HPP using two survey instruments: the HPP Impact Patient Survey (HIPS) and the HPP Outcomes Study Telephone interview (HOST).

METHODS: Between September 2009 and June 2011, pediatric patients (aged younger than 18 years) with HPP were recruited to participate in the study via …

Functionalized Heterocyclics As Potential Therapeutics, Anupama Indukuri

Theses and Dissertations

Heterocyclic compounds play an important role in pharmaceutical drug development. Several natural products and biologically active compounds contain heterocyclic motifs in them. Multicomponent coupling reactions offer an excellent platform for the synthesis of diverse libraries of heterocyclic compounds. We have been working on the synthesis of novel heterocyclic small molecules utilizing reactions such as Baylis-Hillman reaction, Passerini reaction, Click reaction, reductive amination aldol condensation, etc.

In the current project, we prepared three series of heterocyclic compounds using Passerini and Baylis-Hillman reactions as key steps. Owing to the importance of heterocyclic chemistry in drug discovery and the ease of synthesis, the …

Mindfulness And Blood Pressure Across Demographics: Analyses From The Serenity Study, Gabrielle R. Chin

Theses and Dissertations

Mindfulness, as a state, trait, and training, is linked with myriad positive mental and physical health outcomes. Understanding the individual characteristics potentially influencing links between mindful traits, mindfulness training, and physical health, is therefore important, yet remains under-addressed. Utilizing data from the ongoing Serenity Study (NCT02371317), the current project examines if (1) at baseline, higher trait mindfulness relates to lower BP consistently as a function of demographics, (2) Mindfulness-Based Stress Reduction (MBSR) training lowers BP consistently across demographic subgroups and initial levels of trait mindfulness, and (3) if change in trait mindfulness following MBSR training correlates with change in BP …

Feasibility Pilot Outcomes Of A Mammography Decision Support And Navigation Intervention For Women With Serious Mental Illness Living In Supportive Housing Settings., Lara Weinstein, Marianna Lanoue, Katelyn Hurley, Colleen Payton, Randa Sifri, Ronald Myers

Department of Family & Community Medicine Faculty Papers

Objective: People with serious mental illness (SMI) experience significant disparities in morbidity and mortality from preventable and treatable medical conditions. Women with SMI have low mammography screening rates. SMI, poverty, and poor access to care can have a significant effect on a woman’s opportunity to learn about and discuss breast cancer screening with health care providers. This study examines the feasibility pilot outcomes of mammography decision support and patient navigation intervention (DSNI) for women with SMI living in supportive housing settings. The primary research question was: Does the DSNI increase knowledge, promote favorable attitudes, and decrease decisional conflict relating to …

A Novel Eye Tracking Paradigm For Indexing Social Avoidance-Related Behavior In Fragile X Syndrome, Jessica Klusek, Carly Moser, Joseph Schmidt, Leonard Abbeduto, Jane E. Roberts

Faculty Publications

Fragile X syndrome (FXS) is characterized by hallmark features of gaze avoidance, reduced social approach, and social anxiety. The development of therapeutics to manage these symptoms has been hindered, in part, by the lack of sensitive outcome measures. This study investigated the utility of a novel eye tracking paradigm for indexing social avoidance-related phenotypes. Adolescent/young adult-aged males with FXS (n=24) and typical development (n=23) participated in the study. Participants viewed faces displaying direct or averted gaze and the first fixation duration on the eyes was recorded as an index of initial stimulus registration. Fixation durations did …

N-Glycosylation-Defective Splice Variants Of Neuropilin-1 Promote Metastasis By Activating Endosomal Signals, Xiuping Huang, Qing Ye, Min Chen, Aimin Li, Wenting Mi, Yuxin Fang, Yekaterina Y. Zaytseva, Kathleen L. O'Connor, Craig W. Vander Kooi, Side Liu, Qing-Bai She

Markey Cancer Center Faculty Publications

Neuropilin-1 (NRP1) is an essential transmembrane receptor with a variety of cellular functions. Here, we identify two human NRP1 splice variants resulting from the skipping of exon 4 and 5, respectively, in colorectal cancer (CRC). Both NRP1 variants exhibit increased endocytosis/recycling activity and decreased levels of degradation, leading to accumulation on endosomes. This increased endocytic trafficking of the two NRP1 variants, upon HGF stimulation, is due to loss of N-glycosylation at the Asn150 or Asn261 site, respectively. Moreover, these NRP1 variants enhance interactions with the Met and β1-integrin receptors, resulting in Met/β1-integrin co-internalization and co-accumulation on endosomes. This provides persistent …

Effectiveness Of Community Outreach Hiv Prevention Programs In Vietnam: A Mixed Methods Evaluation, Lora L. Sabin, Katherine Semrau, Mary Bachman Desilva, Le T T Loan, Jennifer J. Beard, Davidson H. Hamer, Jordan Tuchman, Ted Hammett, Nafisa Halim, Manisha Reuben, Aldina Mesic, Taryn Vian

Nursing and Health Professions Faculty Research and Publications

Background

In 2014, Vietnam was the first Southeast Asian country to commit to achieving the World Health Organization’s 90–90-90 global HIV targets (90% know their HIV status, 90% on sustained treatment, and 90% virally suppressed) by 2020. This pledge represented further confirmation of Vietnam’s efforts to respond to the HIV epidemic, one feature of which has been close collaboration with the U.S. President’s Emergency Plan for AIDS Relief (PEPFAR). Starting in 2004, PEPFAR supported community outreach programs targeting high-risk populations (people who inject drugs, men who have sex with men, and sex workers). To provide early evidence on program impact, …

Ed Stories: An Online Emergency Medicine Residency Community Building And Wellness Initiative., Geoffrey B Comp, Meenal Sharkey

Medical Education Articles

The "ED Stories" project is a novel method for promoting individual wellness and interpersonal relationships on a virtual platform in an emergency medicine residency program. We engaged multiple individuals across all levels of medical training on a virtual platform to facilitate discussion regarding difficult situations, patient interactions, and tips on how to succeed in challenge circumstances in the future. The platform was outlined as a "safe space," free of judgment and criticism. We engaged 54 participants with a culmination of 131 interactions; there were 14 original posts with a total of 22 comments. We believe that this virtual platform allowed …

Development Of An Imaging Analysis Algorithm For Fluorescence-Based High Content Screening In Parkinson’S Disease, Ryan Arlinghaus

The Journal of Purdue Undergraduate Research

No abstract provided.

A Pharmacological Model Of Trpa1-Mediated Nociception In Zebrafish For Therapeutic Discovery, Emre Coskun

The Journal of Purdue Undergraduate Research

No abstract provided.

Innovative Information Visualization Of Symptom Cluster Management Data: A Systematic Literature Review, Kalika Q. Lacy, Benjamin Carpenter

The Journal of Purdue Undergraduate Research

No abstract provided.

Visualization Of Global Opioid Use Disorder Rates Based On Harm Reduction Availability, Soyol Enkh-Amgalan

The Journal of Purdue Undergraduate Research

No abstract provided.

Characteristics Of Nanoparticles Emitted From Kanthal A1 And Nichrome Heaters Used In Electronic Cigarettes, Kaushal Arvind Prasad

The Journal of Purdue Undergraduate Research

No abstract provided.

Ticked Off: How Expansion Of City Boundaries Affects Rates Of Lyme Disease In The United States, Daphne Fauber

The Journal of Purdue Undergraduate Research

No abstract provided.

Psychiatric Service Dogs: Use And Value For Military Veterans With Ptsd, Catherine Ephlin

The Journal of Purdue Undergraduate Research

No abstract provided.

Analysis Of Manganese Accumulation In The Pituitary Gland And Hippocampus Of Smelters Using High Resolution 3-D T1-Weighted Mri, Alison Jeffries, Zeinab Aly, Molly Cromer

The Journal of Purdue Undergraduate Research

No abstract provided.

Developing Drug Therapies: Cognitive Damage In Mice Following Brain Radiation, Rachel Yuska

The Journal of Purdue Undergraduate Research

Pediatric brain cancer patients are at a high risk for radiation-induced cognitive impairment due to white matter changes in the brain. Half of six-month radiotherapy survivors develop significant changes in white matter. Previous research has shown that a mouse model can be used to show similar cognitive and behavioral deficits in human patients. The purpose of this work is to evaluate the effectiveness of two drug therapies, Donepezil and 3,3-Diindolylmethane (DIM), that could be used to either protect the brain from radiation injury or cure the cognitive injury and behavioral deficits that result from whole-brain irradiation. This project consisted of …

Nanomaterial-Agrichemical Interactions: Association Of Environmental Herbicides With Two-Dimensional Graphene Nanoplatelets, Nudar A. Bhuiya

The Journal of Purdue Undergraduate Research

Atrazine and glyphosate are the two most common agricultural herbicides used in the United States. Both herbicides can move in the environment, which results in contamination of drinking water sources. Graphene nanoplatelets (GNPs) are an emerging nanoparticle with potential uses for the remediation of environmental contamination. The first aim of this study was to determine binding interactions between atrazine and GNPs to mimic a mixture composition. To determine binding interactions, GNPs with different functional groups (none, carboxylated, or aminylated) were evaluated. GNPs at concentrations of 0, 0.5, 1, 2, or 3 mg/ml were incubated with atrazine at 3 ppb (μg/L) …

Data Analytics For Healthcare Management Mhm 508, Joanna Burkhardt

Library Impact Statements

No abstract provided.

Measures Of Fluid Loss During Surfing: A Preliminary Analysis In Recreational Surfers, Rudi A. Meir, Zachary James Crowley-Mchattan Dr, Lyndon O. Brooks, Blake Duncan, Christian Gorrie, Jeremy Sheppard

International Journal of Aquatic Research and Education

Surfing is a popular sport, but little is known about the extent to which recreational surfers experience fluid loss from this activity. The principal objective of this research was to estimate fluid loss during a surfing session through changes in pre- to post-session urine color (Ucol), urine osmolality (Uosm), and body mass (BM). Data were collected from 11 recreational surfers across 14 surf sessions conducted under various environmental (mean water temperature = 22.1 SD ± 2.3; range = 20-26^oC; air temperature range = 13.1-31.5^oC; relative humidity range = 37.5-88.1%) and surfing conditions (e.g. winter/summer, wave type, …

From Treading Water To Swimming Uphill: A Comprehensive And Innovative Assessment Program For Teaching Swimming In Belgian Primary Schools., Filip Roelandt

International Journal of Aquatic Research and Education

According to the World Health Organization (WHO), every child should learn to swim as a recognised life skill. Which swimming skill or stroke to learn first is not the most important question. What is important is to teach children to learn tasks or techniques which allow them to they feel safe. Emphasizing foundational principles of motor development and focusing on safety in and around the water are paramount. Beginning in 2016 school swimming lessons in Flanders (Belgium) were given a new focus in all educational institutions. Foundational competence tasks replaced the focus on acquiring competitive swimming strokes as the primary …

Stem Opportunities - High School 2019, Huey-Xian Kelly Wong, Madeleine Rauhauser, Annie Morgan Nelson

Honors Program: Expanded Learning Clubs

This publication details the lesson plan for the “Opportunities in STEM” club for the summer of 2019. This club began out of a desire to educate high school students about the opportunities and careers available in the science, technology, engineering, and mathematics fields. Often, students feel that the prospect of entering a STEM field is daunting and out of their grasp. What it means to be a scientist is often unclear, and students never consider opportunities out of the fear of the unknown, particularly when science is associated with complexity and difficulty. This lesson plan integrates experiments with a wealth …

Economics For Healthcare Management Mhm 504, Andree Rathemacher

Library Impact Statements

No abstract provided.

Head Depth And Head Speed During Competitive Backstroke Ledge Starts, Wesley J. Manz, Joel T. Greenshields, Brian V. Wright, Curtis S. Goss, Benjamin C. Skutnik, Joel M. Stager

International Journal of Aquatic Research and Education

Recently, a commercially available starting ‘ledge’ designed to reduce foot slippage during the execution of the backstroke start was introduced in competitive swimming. For the purpose of identifying potential safety consequences, the present study investigated the effect of ledge use on head depths, speeds, and distances in backstroke starts of athletes with no prior or only novice familiarity of the ledge. Competitive backstroke starts were performed with and without ledges by high school-aged (14.5 to 19.2 yr, N = 61) swimmers in 1.52 m of water during a closed testing session. A SIMI Reality Motion System in a calibrated space …

Response Of Human Small Intestinal Epithelium To Fractionated Irradiation: Dynamical Modeling Approach, Francis A. Cucinotta, Olga A. Smirnova

Health Physics and Diagnostic Sciences Faculty Research

A biologically motivated mathematical model of the dynamics of the small intestinal epithelium in humans treated with fractionated radiotherapy has been developed and is further investigated here. This model, originating from our previous work, is implemented as a system of nonlinear ordinary differential equations, in which the variables and parameters have a clear biological meaning. The model also includes, as input, the key parameters of fractionated irradiation. The modeling results on the dynamical response of the human normal small intestinal epithelium to fractionated radiation therapy regimens were in agreement with the corresponding empirical data, which, in turn, demonstrates the capability …

Meta-Analysis Of Cognitive Performance By Novel Object Recognition After Proton And Heavy Ion Exposures, Eliedonna Cacao, Francis A. Cucinotta

Health Physics and Diagnostic Sciences Faculty Research

Experimental studies of cognitive detriments in mice and rats after proton and heavy ion exposures have been performed by several laboratories to investigate possible risks to astronauts exposed to cosmic rays in space travel and patients treated for brain cancers with proton and carbon beams in Hadron therapy. However, distinct radiation types and doses, cognitive tests and rodent models have been used by different laboratories, while few studies have considered detailed dose-response characterizations, including estimates of relative biological effectiveness (RBE). Here we report on the first quantitative meta-analysis of the dose response for proton and heavy ion rodent studies of …