Medicine and Health Sciences Commons^™

The Good, The Bad, And The Ugly Behavior, Michal Lavi

Cardozo Law Review

Shaming is usually referred to as the publication of perceived anti-social or illegal behavior of an individual in order to condemn or humiliate him. It has some virtues: it makes it harder for people to get away with wrongful behavior, and it promotes justice. It also promotes freedom of expression and enables efficient deterrence. By spreading information on the behavior of individuals, shaming encourages one to maintain his reputation and facilitates beneficial transactions. Finally, it helps the public to avoid inefficient services.

Yet shaming raises many problems. Anyone can shame another based on individual, as opposed to universal, values, thus …

Early Life Child Micronutrient Status, Maternal Reasoning, And A Nurturing Household Environment Have Persistent Influences On Child Cognitive Development At Age 5 Years: Results From Mal-Ed, Benjamin J J. Mccormick, Stephanie A. Richard, Laura E. Caulfield, Laura L. Pendergast, Jessica C. Seidman, Beena Koshy, Reeba Roshan, Rita Shrestha, Erling Svensen, Muneera Rasheed

Department of Paediatrics and Child Health

Background: Child cognitive development is influenced by early-life insults and protective factors. To what extent these factors have a long-term legacy on child development and hence fulfillment of cognitive potential is unknown.
Objective: The aim of this study was to examine the relation between early-life factors (birth to 2 y) and cognitive development at 5 y.
Methods: Observational follow-up visits were made of children at 5 y, previously enrolled in the community-based MAL-ED longitudinal cohort. The burden of enteropathogens, prevalence of illness, complementary diet intake, micronutrient status, and household and maternal factors from birth to 2 y were extensively measured …

Acute Cardiovascular Response To Low-Load Unilateral, Bilateral, And Alternating Resistance Exercise With Blood Flow Restriction In The Lower Body, Daphney Stanford

Master's Theses

Resistance exercise with blood flow restriction (BFR) has been suggested to exaggerate the exercise pressor response over traditional non-BFR exercise. While applying BFR relative to an individual’s arterial occlusion pressure (AOP) and exercising at low-loads seems to produce a comparable cardiovascular response to traditional moderate or high-load training, it is beneficial to identify modifications for reducing the cardiovascular response to BFR exercise. PURPOSE: To determine if unilateral (UNI), bilateral (BI), or alternating (ALT) exercise modalities elicit different cardiovascular responses during BFR exercise. METHODS: 18 participants (13 male and 5 female) performed four sets of UNI, BI, and ALT knee-extensions at …

Newly Defined Atp-Binding Cassette Subfamily B Member 5 Positive Dermal Mesenchymal Stem Cells Promote Healing Of Chronic Iron-Overload Wounds Via Secretion Of Interleukin-1 Receptor Antagonist, Seppe Vander Beken, Juliane C. De Vries, Barbara Meier-Schiesser, Patrick Meyer, Dongsheng Jiang, Anca Sindrilaru, Filipa F. Ferreira, Adelheid Hainzl, Susanne Schatz, Jana Muschhammer, Natalie J. Scheurmann, Panagiotis Kampilafkos, Andreas M. Seitz, Lutz Dürselen, Anita Ignatius, Mark A. Kluth, Christoph Ganss, Meinhard Wlaschek, Karmveer Singh, Pallab Maity, Natasha Y. Frank, Markus H. Frank, Karin Scharffetter-Kochanek

Research outputs 2014 to 2021

In this study, we report the beneficial effects of a newly identified dermal cell subpopulation expressing the ATP‐binding cassette subfamily B member 5 (ABCB5) for the therapy of nonhealing wounds. Local administration of dermal ABCB5⁺‐derived mesenchymal stem cells (MSCs) attenuated macrophage‐dominated inflammation and thereby accelerated healing of full‐thickness excisional wounds in the iron‐overload mouse model mimicking the nonhealing state of human venous leg ulcers. The observed beneficial effects were due to interleukin‐1 receptor antagonist (IL‐1RA) secreted by ABCB5⁺‐derived MSCs, which dampened inflammation and shifted the prevalence of unrestrained proinflammatory M1 macrophages toward repair promoting anti‐inflammatory M2 …

The Role Of Secretory Phospholipase A2 Group Iia In Obesity And Metabolism, Michael S. Kuefner

Theses and Dissertations (ETD)

Secretory phospholipase A2 group IIA (PLA2G2A) is a member of a family of secretory phospholipases previously implicated in inflammation, atherogenesis, and antibacterial actions. These enzymes hydrolyze glycerophospholipids at the sn-2 position releasing lysophospholipids and fatty acids. Though studies have shown PLA2G2A is pro-inflammatory and promotes atherosclerosis, no research has analyzed the role of this enzyme in obesity and metabolism. Studies in the past 5-10 years utilizing various knock- out or over-expression mouse models have analyzed the role of different secretory phospholipase A2s (sPLA2) in metabolic diseases. From these studies, it is known that at least seven of the 11 sPLA2 …

Investigation Of Riluzole’S Synaptic Protection Mechanism Through Hsf1-Bdnf Axis, Yi Zhang

Theses and Dissertations (ETD)

The FDA-approved amyotrophic lateral sclerosis (ALS) drug Riluzole has great potential in treating Alzheimer’s disease (AD) based on promising animal data as well as its known action on modulating synaptic transmission. However, its detailed mechanism of action is not fully understood. Here, we proposed work aiming to address this aspect via focus- ing on the Heat Shock Factor 1 (HSF1)-dependent mechanisms. We found that Riluzole could increase HSF1 and BDNF (Brain-Derived Neurotrophic Factor) expression both at transcriptional and translational levels. CA1 (Cornu Ammonia, the first region in the hip- pocampal circuit), is its main target. We also demonstrated a protective …

Antibiotic Drug Discovery Targeting Bacterial Metabolism, Miranda J. Wallace

Theses and Dissertations (ETD)

Over the last century, the use of antibiotics has enabled many advances in modern medicine, making life as we know it possible. In recent years, however, emerging bacterial resistance to virtually all major antibiotic classes has resulted in a worldwide increase in morbidity, mortality, and financial burden associated with drug resistant infections. The antimicrobial resistance crisis presents an urgent need for new antimicrobials with distinct mechanisms of action from existing drugs. The current pharmaceutical pipeline of new antibiotics is limited due to three obstacles: a lack of understanding of resistance mechanisms, a dearth of novel mechanisms of action among new …

Fear Learning And The Olfactory Bulb: Neural Correlates Of Behavioral Fear Generalization, Jordan Marie Ross

Theses and Dissertations (ETD)

The exploration of how learning alters neural coding to guide behaviors remains fundamental to neuroscience. At the most basic level, the ability for organisms to flexibly adapt to changing environments and situations is paramount to biological success and often manifests in behavioral responses controlled by neural activity. For example, organisms must modify their behavior to defensive responses in the face of biological threat. Neural circuitry is involved in coordinating an initial defensive behavioral response but must undergo reorganization in order to reliably employ defensive responses in subsequent encounters based on a cue that signals imminent danger. One such form of …

Investigation Of Narrow Spectrum Targets In Antibacterial Drug Discovery, Jesse Jones

Theses and Dissertations (ETD)

Background: Significant concerns are associated with the use of broad-spectrum antibacterial agents, including collateral eradication of beneficial bacteria from the human microbiome, the onset of antibacterial-associated infections, and continued emergence of antibacterial drug resistance. As such, a critical need for novel and selective antibacterial targets exists. The investigation of two such targets, each pertaining to the highly concerning infections caused by streptococcal species and Clostridioides difficile, are presented herein. Bacterial topoisomerase I represents a potentially promising narrow-spectrum target as studies have arisen demonstrating its essentiality in bacterial species lacking the only other type IA topoisomerase (topoisomerase III). Additionally, recent studies …

Including Ultrasound Scans In Antenatal Care In Low-Resource Settings: Considering The Complementarity Of Obstetric Ultrasound Screening And Maternity Waiting Homes In Strengthening Referral Systems In Low-Resource, Rural Settings, David L. Swanson, Holly L. Franklin, Jonathan O. Swanson, Robert L. Goldenberg, Elizabeth M. Mcclure, Waseem Mirza, David Muyodi, Lester Figueroa, Farnaz Naqvi, Sarah Saleem

Department of Radiology

Recent World Health Organization (WHO) antenatal care recommendations include an ultrasound scan as a part of routine antenatal care. The First Look Study, referenced in the WHO recommendation, subsequently shows that the routine use of ultrasound during antenatal care in rural, low-income settings did not improve maternal, fetal or neonatal mortality, nor did it increase women's use of antenatal care or the rate of hospital births. This article reviews the First Look Study, reconsidering the assumptions upon which it was built in light of these results, a supplemental descriptive study of interviews with patients and sonographers that participated in the …

Millennial Midwifery: Online Connectivity In Midwifery Education, Sadie Geraghty, Angela Bromley, Angela Bull, Mpho Dube, Cindy Turner

Research outputs 2014 to 2021

Aim: The aim of this study was to explore graduate midwives’ experiences of completing a Bachelor of Midwifery online theory course and how that experience led to preparation for practice and future employment as a midwife. Methods: This study used a questionnaire, with the core research design having a quantitative component using open-ended questions, via the use of an electronic platform. Results: The main themes emerging from the data that the graduates considered important issues were flexibility, isolation and lack of support. Conclusion: Course completion, experience of online learning/preparation for practice, and recommendations for improvement were identified as areas of …

Association Of Office And Ambulatory Blood Pressure With Mortality And Cardiovascular Outcomes, Wen-Yi Yang, Jesus D. Melgarejo, Lutgarde Thijs, Zhen-Yu Zhang, José Boggia, Fang-Fei Wei, Tine W. Hansen, Kei Asayama, Gladys E. Maestre, Takayoshi Ohkubo

School of Medicine Publications

Importance Blood pressure (BP) is a known risk factor for overall mortality and cardiovascular (CV)-specific fatal and nonfatal outcomes. It is uncertain which BP index is most strongly associated with these outcomes.

Objective To evaluate the association of BP indexes with death and a composite CV event.

Design, Setting, and Participants Longitudinal population-based cohort study of 11 135 adults from Europe, Asia, and South America with baseline observations collected from May 1988 to May 2010 (last follow-ups, August 2006-October 2016).

Exposures Blood pressure measured by an observer or an automated office machine; measured for 24 hours, during the day or …

Role Of Naltrexone In Improving Compulsive Drinking In Psychogenic Polydipsia, Sukaina Rizvi, Jeffery Gold, Ali M. Khan

School of Medicine Publications

Psychogenic polydipsia or self-induced water intoxication is a potentially lethal condition seen in many chronic psychiatric patients. This is a literature review based on therapeutic significance of Naltrexone in improving compulsive water drinking behavior in chronic psychiatrically ill patients with psychogenic polydipsia. Naltrexone is an opioid antagonist approved by FDA for alcohol dependence. Extensive literature search provides a line of evidence that suggests correlation of opioid receptor with compulsive water ingestion in animals. However, there is limited data regarding clinical utility of naltrexone in improving psychogenic polydipsia in human species. This review highlights the necessity for further research and trials …

The Effectiveness Of Selective Serotonin Reuptake Inhibitors For Treatment Of Obsessive-Compulsive Disorder In Adolescents And Children: A Systematic Review And Meta-Analysis, Vijaya P. Kotapati, Ali M. Khan, Sara Dar, Gulshan Begum, Ramya Bachu, Mahwish Adnan, Aarij Zubair, Rizwan A. Ahmed

School of Medicine Publications

Background: Obsessive-compulsive disorder (OCD) is a common behavioral disorder among adolescents and children. The selective serotonin reuptake inhibitors (SSRIs) are the first pharmacological choice for this condition due to mild adverse effect profile.

Objective: This systematic review was performed to evaluate the efficacy of SSRI for OCD in adolescents and children.

Methods: Search terms were entered into PubMed, PsycINFO, Scopus, CINAHL, and Google Scholar. The included studies were randomized, placebo-controlled trials of SSRIs conducted in populations of children and adolescents younger than 18 years. Change from baseline Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS), end-treatment CY-BOCS with respective SD, and response and …

Next-Generation Paclitaxel-Nanoparticle Formulation For Pancreatic Cancer Treatment, Andrew Massey, Mohammed Sikander, Neeraj Chauhan, Sonam Kumari, Saini Setua, Advait B. Shetty, Hassan Mandil, Vivek K. Kashyap, Sheema Khan, Meena Jaggi, Murali M. Yallapu, Bilal B. Hafeez, Subhash C. Chauhan

School of Medicine Publications

Pancreatic cancer (PanCa) is a major cause of cancer-related death due to limited therapeutic options. As pancreatic tumors are highly desmoplastic, they prevent appropriate uptake of therapeutic payloads. Thus, our objective is to develop a next-generation nanoparticle system for treating PanCa. We generated a multi-layered Pluronic F127 and polyvinyl alcohol stabilized and poly-L-lysine coated paclitaxel loaded poly(lactic-co-glycolic acid) nanoparticle formulation (PPNPs). This formulation exhibited optimal size (~160 nm) and negative Zeta potential (−6.02 mV), efficient lipid raft mediated internalization, pronounced inhibition in growth and metastasis in vitro, and in chemo-naive and chemo-exposed orthotopic xenograft mouse models. Additionally, PPNPs altered nanomechanical …

Periodontal Pathogens Are A Risk Factor Of Oral Cavity Squamous Cell Carcinoma, Independent Of Tobacco And Alcohol And Human Papillomavirus, Ian Ganly, Liying Yang, Rachel Giese, Yuhan Hao, Carlos W. Nossa, Luc G. T. Morris, Matthew Rosenthal, Jocelyn Migliacci, Dervla Kelly, Wenzhi Tseng

School of Medicine Publications

Over the past decade, there has been a change in the epidemiology of oral cavity squamous cell cancer (OC-SCC). Many new cases of OC-SCC lack the recognized risk factors of smoking, alcohol and human papilloma virus. The aim of this study was to determine if the oral microbiome may be associated with OC-SCC in nonsmoking HPV negative patients. We compared the oral microbiome of HPV-negative nonsmoker OC-SCC(n = 18), premalignant lesions(PML) (n = 8) and normal control patients (n = 12). Their oral microbiome was sampled by oral wash and defined by 16S rRNA gene sequencing. We report that the …

Computed Tomography Imaging Findings Of Acute Aortic Pathologies, Elif S. Duran, Farhan Ahmad, Mohamed Elshikh, Irfan Masood, Cihan Duran

School of Medicine Publications

Acute aortic syndromes (AAS) encompass a spectrum of life-threatening conditions characterized by acute aortic pain. AAS include acute aortic dissection, intramural hematoma, penetrating atherosclerotic ulcer, and aneurysm rupture. The prognosis of AAS is clearly related to prompt diagnosis and appropriate management. The different types of AAS cannot be reliably differentiated solely based on clinical presentation since the clinical features are indistinguishable. Multidetector-row computed tomography (MDCT) with electrocardiographic gating (ECG-gated MDCT) has been used in the acute emergency setting as a powerful clinical tool, which enables rapid and specific diagnosis of aortic pathologies. ECG-gated MDCT significantly reduces motion artifact and avoids …

Unimóvil: A Mobile Health Clinic Providing Primary Care To The Colonias Of The Rio Grande Valley, South Texas, Eron G. Manuosv, Vincent P. Diego, Jacob Smith, Jesus R. Garza Ii, John Lowdermilk, John Blangero, Sarah Williams-Blangero, Francisco Fernandez

School of Medicine Publications

Background: We describe a mobile unit (UniMóvil) designed to improve poor healthcare access delivery to residents in two South Texas underserved Colonias. The interprofessional team measured seven clinical outcomes [obesity, diabetes, hypertension, hypertriglyceridemia, low high-density lipoprotein cholesterol (HDL-C) levels, and depression], and using the Duke Health Profile, assessed the health-related quality of life (HrQoL).

Methods: The investigators used previously reported disease prevalence, an implementation model, and community needs-assessments to design an outreach healthcare delivery model. A retrospective review of the cohort provides data used to determine potential predictors of clinical variables, 11 domains of HrQOL, and inter/intra Colonia …

How Acceptable Is The Hiv/Aids Self-Testing Among Women Attending Immunization Clinics In Effurun, Southern Nigeria, Wasiu Olalekan Adebimpe, Doraebikeme Ebikeme, Olubukunola Omobuwa, Edward Oladejo

Marshall Journal of Medicine

HIV testing remains the gateway to HIV/AIDS prevention, treatment, care and support interventions. In Nigeria, a significant proportion of the populations do not know their HIV status. HIV self-testing done without the help of a healthcare provider could remove identified barriers to HIV testing, and close gaps in HIV treatment and prevention cascades. This study set out to assess the knowledge and acceptability of hiv self-testing (HIVST) among women of child bearing age attending immunization clinics in Effurun, Nigeria. A descriptive, cross-sectional study was conducted among 357 women of child-bearing age selected using multistage sampling technique. Research instrument used was …

Prasugrel Inappropriate Use In Patients Post-Percutaneous Coronary Intervention (Pci). A Single Center Study, Ahmed Amro, Kanaan Mansoor, Mohammad Amro, Amal Sobeih, Obadah Aqtash, Hisham Hirzallah, Alaa Gabi, Madhulika Urella, Waseem Ahmed, Sandra Shenouda, Dr. Rameez Sayyed, Md

Marshall Journal of Medicine

Prasugrel is a thienopyridine that was approved by the US Food and Drug Administration (FDA) in combination with aspirin for the reduction of thrombotic events as well as stent thrombosis in patients with ACS who undergo PCI. This retrospective study aims to assess the frequency of inappropriate use of prasugrel and to emphasize that prasugrel still needs more attention as inappropriate use may result in significant morbidity.

Intralesional Corticosteroids For Long-Term Control Of Primary Cutaneous Marginal Zone Lymphoma Without Systemic Involvement, Pragya Tiwari, John Hall, Anand Rajpara, Carol Stanford, Daniel Aires

Marshall Journal of Medicine

Primary cutaneous marginal zone lymphoma (PCMZL) is a B cell lymphoma with a very low metastatic rate. Radiographic monitoring for internal involvement may be indicated initially. Favored treatments include radiation and excision. Radiation has high risk of local recurrence. Excision carries risk of infection and scarring. We report successful long-term treatment of recurrent PCMZL via intralesional steroid injections into new lesions as they arose. This was preferred by the patient over her prior radiation and surgical treatments. Intralesional steroids have the advantages of being simple and well tolerated, without exposure to ionizing radiation, or to the infection and scarring associated …

Availability Of Long Acting Reversible Contraceptives For Adolescents In Urban Vs Rural West Virginia Counties, Brooke Andrews, Cameron Ross, Jennie L. Yoost

Marshall Journal of Medicine

The study objective was to evaluate long acting reversible contraceptive (LARC) method availability and access for adolescents in rural and urban counties in West Virginia (WV). A cross-sectional survey of Title X family planning providers throughout WV was conducted from January 2016-July 2017. This survey was sent to 226 family planning providers in WV to assess patterns of LARC availability. The survey assessed provider training level, LARC services provided and frequency, clinical practice, referral patterns, and comfort level providing adolescent LARC services. Survey results were analyzed by providers’ rural vs urban status, based on US census county codes. Survey responses …

Incidental Retroperitoneal Castleman’S Disease Found In Patient With Renal Cell Carcinoma: A Case Report, Samantha Richardson, James Jensen, Niru Nahar, Nadim Bou Zgheib

Marshall Journal of Medicine

This report briefly discusses a case of retroperitoneal Castleman’s disease in a 52 year old post-menopausal woman with renal cell carcinoma.

Group A Streptococcus Brain Abscess In A Patient On Adalimumab Therapy, Ryan Carroll, Ahmad Abu-Hashyeh, James Gainer, Kara Willenburg, Charles Meadows

Marshall Journal of Medicine

Brain abscesses represent a group of dangerous infections typically caused by a number of classic organisms. Group A Streptococcus is a rare cause of brain abscesses and those patients that do have this particular condition will typically have a distal source of infection. We present a case of patient with a biopsy confirmed Group A Streptococcal without a distal source of infection. His only identifiable risk factor was his adalimumab therapy for ankylosing spondylitis. While adalimumab has not been linked to Streptococcal infection in the past, it has been associated with multiple atypical infections and some of the consequences of …

The Challenge Of Electronic Cigarettes, Sutoidem Akpanudo

Marshall Journal of Medicine

No abstract provided.

Giving Hope: Best Healing Power In Medicine, Nadim Bou Zgheib

Marshall Journal of Medicine

No abstract provided.

Extending Our Reach: Looking To The Future For The Marshall Journal Of Medicine, Darshana T. Shah

Marshall Journal of Medicine

No abstract provided.

Trauma-Induced Coagulopathy, Zachary Wise

Nursing Student Class Projects (Formerly MSN)

Trauma-induced coagulopathy (TIC) is a medical emergency requiring effective correction of pathophysiological issues. TIC is antagonized by a lethal triad of factors including hypothermia, acidosis, and coagulopathy. This triad is a vicious cycle that is not seen in every patient that has experienced a physical trauma. However, if it is present, mortality rates quadruple(Phillips, Mohorn, Bookstaver, Ezekiel, & Watson, 2017). Effective correction of this triad can be successfully obtained with the utilization of thromboelastography (TEG). Appropriate usage of TEG promotes patient outcomes while reducing days in the ICU and overall length of stay(Pigna, Lippi, Saronni, & Cervellin, 2018).

The Pathophysiology And Nursing Care For Parkinson's Disease, Meredith Parish

Nursing Student Class Projects (Formerly MSN)

According to the Parkinson's Disease (PD) foundation, PD is a progressive, neurodegenerative disorder that affects predominately dopamine-producing neurons in an area of the brain called the substantia nigra (2019). More than 10 million people worldwide are living with PD, and approximately 60,000 Americans are diagnosed with PD each year ("Understanding parkinson's," 2019). With the growing incidence of this neurodegenerative disease, it is likely that Advanced Practice Nurses (APRN's) in many settings will encounter patients with PD and will have a role in clinical monitoring, identifying when problems arise, and providing care, support, and resources to their PD patients as well …

Sepsis-Induced Dessemination Intravascular Coagulation, Hussainatu Bah

Nursing Student Class Projects (Formerly MSN)

Abstract

This poster focused on Sepsis-Induced DIC, life-threatening complications causing severe coagulopathy that if not recognize and treated early, can lead to multi-organ failure, death, and morbidity. Many patients who come to the hospital for some sort of infection are already at risk for Sepsis-Induced DIC and moreover, surgeries can increase the risk of Sepsis-Induced DIC. It is now understood that the prevention of Sepsis-Induced DIC largely depends on early detection, treatment, and prevention. Advanced Practice Registered Nurses (APRN) need to be well educated on this topic to be effective providers. Five research-based articles with other supporting sources were reviewed …