Medicine and Health Sciences Commons^™

Computed Tomography Imaging Findings Of Acute Aortic Pathologies, Elif S. Duran, Farhan Ahmad, Mohamed Elshikh, Irfan Masood, Cihan Duran

School of Medicine Publications

Acute aortic syndromes (AAS) encompass a spectrum of life-threatening conditions characterized by acute aortic pain. AAS include acute aortic dissection, intramural hematoma, penetrating atherosclerotic ulcer, and aneurysm rupture. The prognosis of AAS is clearly related to prompt diagnosis and appropriate management. The different types of AAS cannot be reliably differentiated solely based on clinical presentation since the clinical features are indistinguishable. Multidetector-row computed tomography (MDCT) with electrocardiographic gating (ECG-gated MDCT) has been used in the acute emergency setting as a powerful clinical tool, which enables rapid and specific diagnosis of aortic pathologies. ECG-gated MDCT significantly reduces motion artifact and avoids …

Association Of Office And Ambulatory Blood Pressure With Mortality And Cardiovascular Outcomes, Wen-Yi Yang, Jesus D. Melgarejo, Lutgarde Thijs, Zhen-Yu Zhang, José Boggia, Fang-Fei Wei, Tine W. Hansen, Kei Asayama, Gladys E. Maestre, Takayoshi Ohkubo

School of Medicine Publications

Importance Blood pressure (BP) is a known risk factor for overall mortality and cardiovascular (CV)-specific fatal and nonfatal outcomes. It is uncertain which BP index is most strongly associated with these outcomes.

Objective To evaluate the association of BP indexes with death and a composite CV event.

Design, Setting, and Participants Longitudinal population-based cohort study of 11 135 adults from Europe, Asia, and South America with baseline observations collected from May 1988 to May 2010 (last follow-ups, August 2006-October 2016).

Exposures Blood pressure measured by an observer or an automated office machine; measured for 24 hours, during the day or …

Plasmid Mediated Colistin Resistance In Enterobacteriaceae Isolated From Feces Of Broiler Chicken In The United Arab Emirates, Sara Abdelkafi Mahmoud Ali

Theses

Although human infections with colistin-resistant Mcr-producing Enterobacteriaceae have been reported from the Arabian Peninsula, the presence of mcr gene in strains of animal origin has not been studied.

Ten composite faecal samples were collected in each of four geographically distant poultry farms in Abu Dhabi Emirate. Ten colonies from McConkey agar containing 1 mg/L colistin from each sample were PCR-screened for mcr-1, mcr-2, MCR-3, mcr-4, mcr-5. Of the positive ones, one isolate representing each distinct plasmid profile was selected for susceptibility testing and for whole-genome sequencing (WGS). Transfer of the MCR-1 gene into Escherichia coli …

Data-Driven Surgical Duration Prediction Model For Surgery Scheduling: A Case-Study For A Practice-Feasible Model In A Public Hospital, Kar Way Tan, Francis Ngoc Hoang Long Nguyen, Boon Yew Ang, Jerald Gan, Sean Shao Wei Lam

Research Collection School Of Computing and Information Systems

Hospitals have been trying to improve the utilization of operating rooms as it affects patient satisfaction, surgery throughput, revenues and costs. Surgical prediction model which uses post-surgery data often requires high-dimensional data and contains key predictors such as surgical team factors which may not be available during the surgical listing process. Our study considers a two-step data-mining model which provides a practical, feasible and parsimonious surgical duration prediction. Our model first leverages on domain knowledge to provide estimate of the first surgeon rank (a key predicting attribute) which is unavailable during the listing process, then uses this predicted attribute and …

An Analysis Of The Evolving Intellectual Structure Of Health Information Systems Research In The Information Systems Discipline, Langtao Chen, Aaron Baird, Detmar W. Straub

Business and Information Technology Faculty Research & Creative Works

The rapid evolution of health information systems (Health IS) research has led to many significant contributions. However, while the Health IS subset of information systems (IS) scholarship has considerably grown over the past two decades, this growth has led to questions regarding the current intellectual structure of this area of inquiry. In an effort to more fully understand how Health IS research has contributed to the IS discipline, and what this may mean for future Health IS research in the IS domain, we conduct an in-depth evaluation of Health IS research published in mainstream IS journals. We apply citation analysis, …

Role Of Naltrexone In Improving Compulsive Drinking In Psychogenic Polydipsia, Sukaina Rizvi, Jeffery Gold, Ali M. Khan

School of Medicine Publications

Psychogenic polydipsia or self-induced water intoxication is a potentially lethal condition seen in many chronic psychiatric patients. This is a literature review based on therapeutic significance of Naltrexone in improving compulsive water drinking behavior in chronic psychiatrically ill patients with psychogenic polydipsia. Naltrexone is an opioid antagonist approved by FDA for alcohol dependence. Extensive literature search provides a line of evidence that suggests correlation of opioid receptor with compulsive water ingestion in animals. However, there is limited data regarding clinical utility of naltrexone in improving psychogenic polydipsia in human species. This review highlights the necessity for further research and trials …

Millennial Midwifery: Online Connectivity In Midwifery Education, Sadie Geraghty, Angela Bromley, Angela Bull, Mpho Dube, Cindy Turner

Research outputs 2014 to 2021

Aim: The aim of this study was to explore graduate midwives’ experiences of completing a Bachelor of Midwifery online theory course and how that experience led to preparation for practice and future employment as a midwife. Methods: This study used a questionnaire, with the core research design having a quantitative component using open-ended questions, via the use of an electronic platform. Results: The main themes emerging from the data that the graduates considered important issues were flexibility, isolation and lack of support. Conclusion: Course completion, experience of online learning/preparation for practice, and recommendations for improvement were identified as areas of …

Rosai-Dorfman's Disease, An Uncommon Cause Of Common Clinical Presentation, Om Parkash, Mian Shah Yousaf, Ghulam Fareed

Section of Gastroenterology

Sinus histiocytosis with massive lymphadenopathy also known as Rosai-Dorfman disease is a rare benign disease that typically manifests as lymphadenopathy with or without systemic manifestations whose etiology remains poorly understood. Most common clinical presentation is painless bilateral cervical lymphadenopathy. However, it also can present in various extranodal sites and can easily be missed because of its rarity if not considered in the differential diagnosis. It commonly occurs in children and young adults with a slightly male predominance. Clinically patients may be mistaken for lymphoma and other infectious disorders like tuberculosis especially in developing countries like in Pakistan where tuberculosis is …

A Cross Sectional Study Of Medical Students’ Perception Of Their Educational Environment In Ghana, Temitope Ade-Oshifogun, Jean Amost Cadet, Jochebed B. Ade-Oshifogun

Faculty Publications

Background: The quality of medical education is affected by many factors, one of which is the educational environment of medical education. However, there is paucity of studies addressing the educational environment from African medical schools. The aim of this study was to determine the clinical year students’ perceptions of their educational environment at a medical school in Ghana. This was done with the goal of identifying factors that may impact positive changes in the school. Methods: A cross-sectional study was undertaken using the DREEM questionnaire. The questionnaire was administered to students in clinical years 1, 2, & 3 at the …

Newly Defined Atp-Binding Cassette Subfamily B Member 5 Positive Dermal Mesenchymal Stem Cells Promote Healing Of Chronic Iron-Overload Wounds Via Secretion Of Interleukin-1 Receptor Antagonist, Seppe Vander Beken, Juliane C. De Vries, Barbara Meier-Schiesser, Patrick Meyer, Dongsheng Jiang, Anca Sindrilaru, Filipa F. Ferreira, Adelheid Hainzl, Susanne Schatz, Jana Muschhammer, Natalie J. Scheurmann, Panagiotis Kampilafkos, Andreas M. Seitz, Lutz Dürselen, Anita Ignatius, Mark A. Kluth, Christoph Ganss, Meinhard Wlaschek, Karmveer Singh, Pallab Maity, Natasha Y. Frank, Markus H. Frank, Karin Scharffetter-Kochanek

Research outputs 2014 to 2021

In this study, we report the beneficial effects of a newly identified dermal cell subpopulation expressing the ATP‐binding cassette subfamily B member 5 (ABCB5) for the therapy of nonhealing wounds. Local administration of dermal ABCB5⁺‐derived mesenchymal stem cells (MSCs) attenuated macrophage‐dominated inflammation and thereby accelerated healing of full‐thickness excisional wounds in the iron‐overload mouse model mimicking the nonhealing state of human venous leg ulcers. The observed beneficial effects were due to interleukin‐1 receptor antagonist (IL‐1RA) secreted by ABCB5⁺‐derived MSCs, which dampened inflammation and shifted the prevalence of unrestrained proinflammatory M1 macrophages toward repair promoting anti‐inflammatory M2 …

Effects Of The 2017 Clinical Practice Guidelines On Hypertension In Children And Adolescents: A Commentary, Bonita Falkner

Department of Medicine Faculty Papers

No abstract provided.

Culturally Appropriate Education In Managing Hypertension In African Americans, Kristina Jones

Doctoral Dissertations and Projects

Abstract The historical treatment of African Americans with events such as the Tuskegee experiment and Jim Crow laws combined with distrust of the healthcare system may be affecting health outcomes in African Americans with hypertension. Cultural appropriate education by a provider of the same race is a method that can be utilized to bridge the trust gap between African Americans and providers and assist African Americans in managing their hypertension. A community based culturally appropriate educational intervention by a provider of the same race was implemented over the course of eight weeks to assist African Americans with hypertension to improve …

Dean's Update, August 2019, Jerry L. Nadler

SOM Dean's Research Newsletter

No abstract provided.

Correlates Of Same-Sex Behavior Disclosure To Health Care Providers Among Black Msm In The United States: Implications For Hiv Prevention, Christina J. Sun, Karin Tobin, Pilgrim Spikes, Carl Latkin

OHSU-PSU School of Public Health Faculty Publications and Presentations

Disclosure of same-sex behavior to health care providers (HCPs) by men who have sex with men (MSM) has been argued to be an important aspect of HIV prevention. However, Black MSM are less likely to disclose compared to white MSM. This analysis of data collected in the United States from 2006–2009 identified individual and social network characteristics of Black MSM (n = 226) that are associated with disclosure that may be leveraged to increase disclosure. Over two-thirds (68.1%) of the sample had ever disclosed to HCPs. Part-time employment (AOR = 0.32, 95% CI = 0.11–0.95), bisexual identity (AOR = …

Clinical Practice Variation Among Adult Infectious Disease Physicians In The Management Of Staphylococcus Aureus Bacteremia, Catherine Liu, Luke Strnad, Susan E. Beekmann, Philip M. Polgreen, Henry F. Chambers

OHSU-PSU School of Public Health Faculty Publications and Presentations

Infectious disease management of Staphylococcus aureus bacteremia (SAB) was surveyed through the Emerging Infections Network. While there were areas of consensus, we found substantial practice variation in diagnostic evaluation and management of adult patients with SAB. These findings highlight opportunities for further research and guidance to define best practices.

How Acceptable Is The Hiv/Aids Self-Testing Among Women Attending Immunization Clinics In Effurun, Southern Nigeria, Wasiu Olalekan Adebimpe, Doraebikeme Ebikeme, Olubukunola Omobuwa, Edward Oladejo

Marshall Journal of Medicine

HIV testing remains the gateway to HIV/AIDS prevention, treatment, care and support interventions. In Nigeria, a significant proportion of the populations do not know their HIV status. HIV self-testing done without the help of a healthcare provider could remove identified barriers to HIV testing, and close gaps in HIV treatment and prevention cascades. This study set out to assess the knowledge and acceptability of hiv self-testing (HIVST) among women of child bearing age attending immunization clinics in Effurun, Nigeria. A descriptive, cross-sectional study was conducted among 357 women of child-bearing age selected using multistage sampling technique. Research instrument used was …

Prasugrel Inappropriate Use In Patients Post-Percutaneous Coronary Intervention (Pci). A Single Center Study, Ahmed Amro, Kanaan Mansoor, Mohammad Amro, Amal Sobeih, Obadah Aqtash, Hisham Hirzallah, Alaa Gabi, Madhulika Urella, Waseem Ahmed, Sandra Shenouda, Dr. Rameez Sayyed, Md

Marshall Journal of Medicine

Prasugrel is a thienopyridine that was approved by the US Food and Drug Administration (FDA) in combination with aspirin for the reduction of thrombotic events as well as stent thrombosis in patients with ACS who undergo PCI. This retrospective study aims to assess the frequency of inappropriate use of prasugrel and to emphasize that prasugrel still needs more attention as inappropriate use may result in significant morbidity.

Intralesional Corticosteroids For Long-Term Control Of Primary Cutaneous Marginal Zone Lymphoma Without Systemic Involvement, Pragya Tiwari, John Hall, Anand Rajpara, Carol Stanford, Daniel Aires

Marshall Journal of Medicine

Primary cutaneous marginal zone lymphoma (PCMZL) is a B cell lymphoma with a very low metastatic rate. Radiographic monitoring for internal involvement may be indicated initially. Favored treatments include radiation and excision. Radiation has high risk of local recurrence. Excision carries risk of infection and scarring. We report successful long-term treatment of recurrent PCMZL via intralesional steroid injections into new lesions as they arose. This was preferred by the patient over her prior radiation and surgical treatments. Intralesional steroids have the advantages of being simple and well tolerated, without exposure to ionizing radiation, or to the infection and scarring associated …

Availability Of Long Acting Reversible Contraceptives For Adolescents In Urban Vs Rural West Virginia Counties, Brooke Andrews, Cameron Ross, Jennie L. Yoost

Marshall Journal of Medicine

The study objective was to evaluate long acting reversible contraceptive (LARC) method availability and access for adolescents in rural and urban counties in West Virginia (WV). A cross-sectional survey of Title X family planning providers throughout WV was conducted from January 2016-July 2017. This survey was sent to 226 family planning providers in WV to assess patterns of LARC availability. The survey assessed provider training level, LARC services provided and frequency, clinical practice, referral patterns, and comfort level providing adolescent LARC services. Survey results were analyzed by providers’ rural vs urban status, based on US census county codes. Survey responses …

Incidental Retroperitoneal Castleman’S Disease Found In Patient With Renal Cell Carcinoma: A Case Report, Samantha Richardson, James Jensen, Niru Nahar, Nadim Bou Zgheib

Marshall Journal of Medicine

This report briefly discusses a case of retroperitoneal Castleman’s disease in a 52 year old post-menopausal woman with renal cell carcinoma.

Group A Streptococcus Brain Abscess In A Patient On Adalimumab Therapy, Ryan Carroll, Ahmad Abu-Hashyeh, James Gainer, Kara Willenburg, Charles Meadows

Marshall Journal of Medicine

Brain abscesses represent a group of dangerous infections typically caused by a number of classic organisms. Group A Streptococcus is a rare cause of brain abscesses and those patients that do have this particular condition will typically have a distal source of infection. We present a case of patient with a biopsy confirmed Group A Streptococcal without a distal source of infection. His only identifiable risk factor was his adalimumab therapy for ankylosing spondylitis. While adalimumab has not been linked to Streptococcal infection in the past, it has been associated with multiple atypical infections and some of the consequences of …

The Challenge Of Electronic Cigarettes, Sutoidem Akpanudo

Marshall Journal of Medicine

No abstract provided.

Giving Hope: Best Healing Power In Medicine, Nadim Bou Zgheib

Marshall Journal of Medicine

No abstract provided.

Extending Our Reach: Looking To The Future For The Marshall Journal Of Medicine, Darshana T. Shah

Marshall Journal of Medicine

No abstract provided.

Trauma-Induced Coagulopathy, Zachary Wise

Nursing Student Class Projects (Formerly MSN)

Trauma-induced coagulopathy (TIC) is a medical emergency requiring effective correction of pathophysiological issues. TIC is antagonized by a lethal triad of factors including hypothermia, acidosis, and coagulopathy. This triad is a vicious cycle that is not seen in every patient that has experienced a physical trauma. However, if it is present, mortality rates quadruple(Phillips, Mohorn, Bookstaver, Ezekiel, & Watson, 2017). Effective correction of this triad can be successfully obtained with the utilization of thromboelastography (TEG). Appropriate usage of TEG promotes patient outcomes while reducing days in the ICU and overall length of stay(Pigna, Lippi, Saronni, & Cervellin, 2018).

The Pathophysiology And Nursing Care For Parkinson's Disease, Meredith Parish

Nursing Student Class Projects (Formerly MSN)

According to the Parkinson's Disease (PD) foundation, PD is a progressive, neurodegenerative disorder that affects predominately dopamine-producing neurons in an area of the brain called the substantia nigra (2019). More than 10 million people worldwide are living with PD, and approximately 60,000 Americans are diagnosed with PD each year ("Understanding parkinson's," 2019). With the growing incidence of this neurodegenerative disease, it is likely that Advanced Practice Nurses (APRN's) in many settings will encounter patients with PD and will have a role in clinical monitoring, identifying when problems arise, and providing care, support, and resources to their PD patients as well …

Sepsis-Induced Dessemination Intravascular Coagulation, Hussainatu Bah

Nursing Student Class Projects (Formerly MSN)

Abstract

This poster focused on Sepsis-Induced DIC, life-threatening complications causing severe coagulopathy that if not recognize and treated early, can lead to multi-organ failure, death, and morbidity. Many patients who come to the hospital for some sort of infection are already at risk for Sepsis-Induced DIC and moreover, surgeries can increase the risk of Sepsis-Induced DIC. It is now understood that the prevention of Sepsis-Induced DIC largely depends on early detection, treatment, and prevention. Advanced Practice Registered Nurses (APRN) need to be well educated on this topic to be effective providers. Five research-based articles with other supporting sources were reviewed …

Development Of Novel Zika And Anthrax Viral Nanoparticle Vaccines, Elizabeth Henderson

KGI Theses and Dissertations

Vaccines protect against numerous infectious diseases and prevent millions of deaths annually, but there are still many infectious diseases for which no licensed vaccine exists. Developing a new vaccine requires balancing safety and efficacy, and viral nanoparticle (VNP) vaccines possess both of these characteristics. The work herein demonstrates how tobacco mosaic virus (TMV) nanoparticles can serve as a platform to create candidate vaccines for Zika virus (ZIKV) and anthrax. In the first study, a ZIKV-specific epitope was genetically fused to TMV to create a safe and inexpensive vaccine that proved highly immunogenic in mice and led to the discovery of …

Identifying Important Parameters In The Inflammatory Process With A Mathematical Model Of Immune Cell Influx And Macrophage Polarization, Marcella Torres, Jing Wang, Paul J. Yannie, Shobha Ghosh, Rebecca A. Segal, Angela M. Reynolds

Department of Math & Statistics Faculty Publications

In an inflammatory setting, macrophages can be polarized to an inflammatory M1 phenotype or to an anti-inflammatory M2 phenotype, as well as existing on a spectrum between these two extremes. Dysfunction of this phenotypic switch can result in a population imbalance that leads to chronic wounds or disease due to unresolved inflammation. Therapeutic interventions that target macrophages have therefore been proposed and implemented in diseases that feature chronic inflammation such as diabetes mellitus and atherosclerosis. We have developed a model for the sequential influx of immune cells in the peritoneal cavity in response to a bacterial stimulus that includes macrophage …

An Exploration Of Attitudes Toward Dogs Among College Students In Bangalore, India, Shelly Volsche, Miriam Mohan, Peter B. Gray, Madhavi Rangaswamy

Anthropology Faculty Research

Conversations in the field of anthrozoology include treatment and distinction of food animals, animals as workers versus pests, and most recently, emerging pet trends including the practice of pet parenting. This paper explores attitudes toward pet dogs in the shared social space of urban India. The data include 375 pen-and-paper surveys from students at CHRIST (Deemed to be University) in Bangalore, India. Reflecting upon Serpell’s biaxial concept of dogs as a relationship of affect and utility, the paper considers the growing trend of pet dog keeping in urban spaces and the increased use of affiliative words to describe these relationships. …