Medicine and Health Sciences Commons^™

Patient And Provider Perspectives On Sexual History Taking During Gynecological Care: A Pilot Study In An Academic Family Medical Setting In New York City, Ashley M. Chastain

Dissertations and Theses

Background: In the United States (US), women face a number of serious issues concerning sexual health. Current surveillance data indicates that overall rates of bacterial sexually transmitted infections (STIs) are increasing rapidly. While rates of new diagnoses have decreased, the risks of acquiring HIV are still relatively high for some females, specifically Black/African-American women. In New York City (NYC), where this dissertation research was conducted, similar HIV/STI rates exist among females of reproductive age (aged 15-44). Among women in the US, there are also high estimated rates of other sexual health problems, such as sexual anxiety, sexual dysfunction, and intimate …

Long-Distance Axon Regeneration Promotes Recovery Of Diaphragmatic Respiratory Function After Spinal Cord Injury., Mark W. Urban, Biswarup Ghosh, Cole G. Block, Laura R. Strojny, Brittany A. Charsar, Miguel Goulão, Sreeya S. Komaravolu, George M. Smith, Megan C. Wright, Shuxin Li, Angelo C. Lepore

Farber Institute for Neuroscience Faculty Papers

Compromise in inspiratory breathing following cervical spinal cord injury (SCI) is caused by damage to descending bulbospinal axons originating in the rostral ventral respiratory group (rVRG) and consequent denervation and silencing of phrenic motor neurons (PhMNs) that directly control diaphragm activation. In a rat model of high-cervical hemisection SCI, we performed systemic administration of an antagonist peptide directed against phosphatase and tensin homolog (PTEN), a central inhibitor of neuron-intrinsic axon growth potential. PTEN antagonist peptide (PAP4) robustly restored diaphragm function, as determined with electromyography (EMG) recordings in living SCI animals. PAP4 promoted substantial, long-distance regeneration of injured rVRG axons through …

Patient Engagement On The Go: Utilizing Mobile Application Technology To Centralize Resources For Behavioral Health Patients, Paul A. Siegfried Ms, Jason Boyko Lpc, Faclp, Brenda Shaffer Msn, Rn, Edward R. Norris Md, Fapa, Fapm

Department of Psychiatry

No abstract provided.

Science Of Lifestyle; Strategies For Change, Raza Ur Rahman

Pakistan Journal of Neurological Sciences (PJNS)

Since the start of 21st century the focus of medical treatment is changing from curative to the preventive medicine and now functional recovery and quality of life are the outcome of curative medicine. These new outcomes of modern medicine can be achieved through adopting the strategies that enhance wellness of patient. The methods of enhancing wellness are in practice since centuries and their effectiveness has been handed down through word of mouth and tradition. They continue to evolve and were first documented in 1970s, by Canyon Ranch1, as a strategy to improve health through the principles of a healthy lifestyle. …

Post-Stroke Seizures: A Clinically Oriented Analysis, Sajid Hameed, Haris Hakeem, Mohammad Wasay

Pakistan Journal of Neurological Sciences (PJNS)

Stroke is an important cause of secondary epilepsy, especially in the elderly. Not only does this impact morbidity and mortality in an adverse way, it also prolongs the hospitalization. Various risk factors have been described in literature that increase the risk of seizures in a patient with stroke. Post stroke seizures fall on a spectrum of acute symptomatic and unprovoked seizures with varying pathophysiology and risk of subsequent development of epilepsy. Hence, the treatment approaches are also different. However, randomized controlled trials are lacking to guide monitoring and management strategies in post stroke seizures and the approaches remain individualized to …

An Overview Of Autism: Is It Treatable In Pakistan?, Tania Nadeem, Rabeeka Aftab, Nargis Asad

Pakistan Journal of Neurological Sciences (PJNS)

Autism Spectrum Disorder (ASD) is a clinically complex, pervasive neurodevelopmental disorder with early appearing social communication deficits and repetitive sensory–motor behaviors.1 Although affected individuals differ significantly from one another, typically the disorder is characterized by impairment in social reciprocity and communication. Children usually have speech delays or lack of social interaction including: lack of eye contact, limited response to name, decreased interest in peers, and restricted shared attention with parents.1 Autistic individuals also exhibit repetitive behaviors like flapping, lining, or stacking objects and narrowly focused rigid interests such as paying particular attention to spinning objects.1 It usually manifests before 3 …

What, When And For Whom Model Of Nutrition: A Health Management Approach, Muhammad Rafiq

Pakistan Journal of Neurological Sciences (PJNS)

Studies have shown that nutrition plays an important role in the pathophysiology of different health issues either physiological, or psychological. Nutrition is implicated in the development of health issues in different ways. The purpose of this mini review was to suggest a comprehensive model of nutrition, “What, When and for Whom Model of Nutrition”, in the light of existing literature. For this purpose, existing literature was explored to study the role of nutrition on mental health in perspective to, what type of nutrition, when it is consumed and/or who consumes it. Researchers concluded that it is not only what we …

Diagnostic Dilemmas Of Progressive Supranuclear Palsy, Humera Saeed, Qurat Ul Ain Khan, Syeda Masharab Jilani, Syeda Maheen Batool

Pakistan Journal of Neurological Sciences (PJNS)

In this report authors discuss similarities between psychiatric phenomenon i.e. catatonia and neuropsychiatric syndromes such as progressive supranuclear palsy (PSP) in a 51 years old male, known case of hypertension and diabetes, who presented to the psychiatric services with mutism, stereotypical movements of upper limbs, echolalia, anteriorly flexed neck, swallowing difficulty, decreased oral intake, urinary and fecal incontinence for a period of 1 year worsened for 6 months. Patient was initially treated for catatonia with benzodiazepines and electroconvulsive therapy but did not improve. A neuropsychiatric consultation was sought and a diagnosis of possible PSP was made according to the National …

The Natural Predominant Sleeping Positions In Cerebral Palsy; Does It Correlate With The Type Of Cerebral Palsy?, Sarah Razaq, Muhammad Aleem Arshad, Tahira Amjad

Pakistan Journal of Neurological Sciences (PJNS)

To see the natural positions of cerebral palsy subjects during sleep and their correlation with the particular type of cerebral palsy.

Tacrolimus-Associated Posterior Reversible Encephalopathy Syndrome In Allogenic Hematopoietic Stem Cell Transplant, Hina Imtiaz, Maryam Jamil Syed, Dureshahwar Kanwar, Bushra Taimuri, Sajid Hameed

Pakistan Journal of Neurological Sciences (PJNS)

Tacrolimus is an immunosuppressive drug used to lower the risk of transplant rejection in individuals after solid organ or hematopoietic transplantation. Cases of posterior reversible encephalopathy syndrome (PRES) as a complication of tacrolimus therapy are infrequently documented. The pathogenesis of this phenomenon is not well understood. Here, we report a case of an 18-year-old female with a history of acute myeloid leukemia that developed PRES after undergoing an allogeneic stem cell transplant and subsequent immunosuppressive therapy with tacrolimus.

Expert Search For The "Effect Of Dental Treatment Before Cardiac Valve Surgery", Kelly K. O'Brien

Expert Search Strategies

This search strategy was constructed to support the research for the peer reviewed article listed above. Full article abstract:

Background

Types of Studies Reviewed

The Role Of Autophagy In Myocardial Ischemia/Reperfusion Injury In Isolated Rat Hearts, Aloysius C. Ibe Ii

PCOM Biomedical Studies Student Scholarship

Autophagy is a housekeeping process used to remove damaged cytoplasmic constituents and protein aggregates. However, a debate persists on whether autophagy is beneficial or detrimental when an ischemic/reperfusion (I/R) insult occurs in the heart. This study tested the effects of autophagy enhancers (rapamycin and trehalose) and an autophagy inhibitor (3-methyladenine) on cardiac function and infarct size after global ischemia (30 minutes) and reperfusion (45 minutes) when given prior to ischemia (pre-treatment) or at the beginning of reperfusion (post-treatment). Rapamycin (25nM) pre-treatment and post-treatment significantly restored final left ventricular developed pressure (LVDP) to 75.4±9.1% and 60±5% of initial baseline respectively (both …

Detection And Concentration Of Plasma Aflatoxin Is Associated With Detection Of Oncogenic Human Papillomavirus In Kenyan Women, Jianjun Zhang, Elkanah Omenge, Philip Tonui, Yan Tong, Titus Manai, Stephen Kiptoo, Kapten Muthoka, John Groopman, Joshua Smith, Erin Madeen

Obstetrics and Gynaecology, East Africa

Background: Cervical cancer is common in Kenyan women. Cofactors in addition to infection with oncogenic human papillomavirus (HPV) are likely to be important in causing cervical cancer, because only a small percentage of HPV-infected women will develop this malignancy. Kenyan women are exposed to dietary aflatoxin, a potent carcinogen and immunosuppressive agent, which may be such a cofactor.

Methods: Demographics, behavioral data, plasma, and cervical swabs were collected from 88 human immunodeficiency virus-uninfected Kenyan women without cervical dysplasia. Human papillomavirus detection was compared between women with or without plasma aflatoxin B1-lysine (AFB1-lys) and evaluated in relation to AFB1-lys concentration.

Results: …

Hidradenitis Suppurativa: A Comparison Of Institutional Experience With The Tracking, Sean J. Wallace Md, Andrew Steele Md, Nathan Miller Md, Yee-Cheng Low Md, Robert X. Murphy Jr, Md, Ms

Department of Surgery

No abstract provided.

Drug Safety Scientometrics Overview Highlights Public Health Issues, Philippe Gorry, Enrique Seoane-Vazquez

Pharmacy Faculty Articles and Research

"Drug Safety (DS) also known as Pharmacovigilance, is the science of monitoring ADR (Cobert, 2012). Despite that DS has a social welfare function, it has not been the study of any scientometrics analysis... Our goal is to fill this gap by mapping the DS literature. This analysis might highlight some trends, the role of drug regulatory and firms in diffusing information, understand better some DS controversial events, help scholars in mastering pharmacovigilance literature, and it contribute to further development on literature-based discovery of ADR [adverse drug reactions] with the help of natural language processing."

Clinical Outcome Assessments Toolbox For Radiopharmaceuticals., Charles A Kunos, Jacek Capala, Adam P Dicker, Benjamin Movsas, Susan Percy Ivy, Lori M Minasian

Department of Radiation Oncology Faculty Papers

For nearly 40 years, the U.S. National Cancer Institute (NCI) has funded health-related quality-of-life (HRQOL) and symptom management in oncology clinical trials as a method for including a cancer patient's experience during and after treatment. The NCI's planned scope for HRQOL, symptom and patient-reported outcomes management research is explained as it pertains to radiopharmaceutical clinical development. An effort already underway to support protocol authoring via an NCI Cancer Therapy Evaluation Program (CTEP) Centralized Protocol Writing Service (CPWS) is described as this service aids incorporation of HRQOL, symptom and patient-reported outcomes management research into sponsored protocols.

Effect Of Low-Dose Ketamine Versus Fentanyl On Attenuating The Haemodynamic Response To Laryngoscopy And Endotracheal Intubation In Patients Undergoing General Anaesthesia: A Prospective, Double-Blinded, Randomised Controlled Trial, Angela Ongewe, Vitalis Mung’Ayi, Rajpreet Bal

Anaesthesiology, East Africa

Background: The use of drugs to attenuate the haemodynamic response to laryngoscopy and endotracheal intubation is the standard of care during elective surgery. Current evidence is conflicting concerning the best agent and optimal dose for this purpose. In the majority of cases, fentanyl is widely utilized to attenuate haemodynamic responses. Ketamine, an established available drug, has been scarcely studied in this regard at low doses and against varying doses of other common agents.

Objective: To compare the overall occurrence of hypertension and tachycardia immediately pre-intubation (post-induction) until 10 minutes post intubation between the study group receiving fentanyl at 1.0 µg/kg …

Development Of A Novel Tool For Assessing Coverage Of Implementation Factors In Health Promotion Program Resources., Carolina M. Bejarano, Kelli Snow, Hannah Lane, Hannah Calvert, Kate Hoppe, Nicole Alfonsin, Lindsey Turner, Jordan A. Carlson

Manuscripts, Articles, Book Chapters and Other Papers

No abstract provided.

A Population Pharmacokinetic Model For Simvastatin And Its Metabolites In Children And Adolescents., Kayode Ogungbenro, Jonathan B. Wagner, Susan M. Abdel-Rahman, J Steven Leeder, Aleksandra Galetin

Manuscripts, Articles, Book Chapters and Other Papers

PURPOSE: Poor adherence to dietary/behaviour modifications as interventions for hypercholesterolemia in paediatric patients often necessitates the initiation of statin therapy. The aim of this study was to develop a joint population pharmacokinetic model for simvastatin and four metabolites in children and adolescents to investigate sources of variability in simvastatin acid exposure in this patient population, in addition to SLCO1B1 genotype status.

METHODS: Plasma concentrations of simvastatin and its four metabolites, demographic and polymorphism data for OATP1B1 and CYP3A5 were analysed utilising a population pharmacokinetic modelling approach from an existing single oral dose (10 mg < 17 years and 20 mg ≥ 18 years) pharmacokinetic dataset of 32 children and adolescents.

RESULTS: The population PK model included …

Antibiotic Prophylaxis In The Surgical Management Of Miscarriage In Low-Income Countries: A Cost-Effectiveness Analysis Of The Aims Trial, Ilias Goranitis, David M. Lissauer, Arri Coomarasamy, Amie Wilson, Jane Daniels, Lee Middleton, Jonathan Bishop, Catherine A. Hewitt, Andrew D. Week, Chisale Mhango, Ronald Mataya, Iffat Ahmed

Department of Obstetrics & Gynaecology

Background: There is ongoing debate on the clinical benefits of antibiotic prophylaxis for reducing pelvic infection after miscarriage surgery. We aimed to study the cost-effectiveness of antibiotic prophylaxis in the surgical management of miscarriage in low-income countries.
Method: We did an incremental cost-effectiveness analysis using data from 3412 women recruited to the AIMS trial, a randomised, double-blind, placebo-controlled trial designed to evaluate the effectiveness of antibiotic prophylaxis in the surgical management of miscarriage in Malawi, Pakistan, Tanzania, and Uganda. Economic evaluation was done from a health-care-provider perspective on the basis of the outcome of cost per pelvic infection avoided within …

The Association Of Tas1r2 To Dental And Cardiovascular Health, Joseph Keryakos, Annika Van Oosbree, Alyssa Marie Kiesow

Faculty Work Comprehensive List

Despite brushing and/or flossing their teeth twice daily, many people are still susceptible to dental cavities and tooth decay. This research investigates the genetic and cardiovascular health behind this phenomenon. Two gene variants related to taste pathways, taste 1 receptor member 2 (TAS1R2) and taste 2 receptor member 38 (TAS2R38), were tested on the DNA of 20 students at Northern State University (10 males and 10 females). In concert with genetic screening, tooth impressions were taken of the participants’ upper and lower jaws along with salivary pH, heart rates, and blood pressures. Participants’ cavities and fillings were counted and their …

Andrews Nursing Students Change The World — One Mission Trip At A Time, Shawna Trotman Henry

Lake Union Herald

No abstract provided.

Nutrinews: September, 2019, Department Of Nutrition And Dietetics, University Of North Florida

NutriNews

This issue features Caffeine: Not a Diuretic After All?, Better Strength Better Health

Inflammation, Depression And Non-Adherence Correlates In Persons On Hemodialysis, Kathleen Fulmer

Loma Linda University Electronic Theses, Dissertations & Projects

The hemodialysis patient is at risk for a high inflammatory state as evidenced by the elevation of the pro-inflammatory cytokine, interleukin-6 which has been linked to lower serotonin levels and development of depression. The biological and psychological stress of living with End Stage Renal Disease on hemodialysis increases the risk for depression which is the leading psychological disorder affecting these patients which is also underdiagnosed and under-treated. The phenomenon of depression can manifest itself in the maladaptive behavior of non-adherence which has been associated with increased mortality, morbidity and decreased quality of life for the hemodialysis patient. The purpose of …

Measurements Of The Pharyngeal Airway Using Whole Head 3t Mri And Cbct, Victoria Geren

Loma Linda University Electronic Theses, Dissertations & Projects

Objective: This study compared pharyngeal airway measurements (volume, linear, area) made using whole head Cone-Beam Computed Tomography (CBCT) and 3T Magnetic Resonance Imaging (MRI) methods.

Methods: Eleven subjects (mean age 15y11m) received whole head CBCT (NewTom5G, AFP Imaging, USA) and 3T MRI (Siemens Medical Solutions, DE). Each subject received both scans within a one-month period of time. CBCT images were made with an 18x16 inch field of view, exposure time of 5.4s, and resolution of 0.3x0.3x0.3mm. 3T MR images were captured as contiguous sagittal images of the whole head with a T1- weighted 3D imaging sequence (Magnetization Prepared …

Clinical Effects Of Oral Hygiene Instruction Via Texting In Orthodontic Patients, Jessica Liu

Loma Linda University Electronic Theses, Dissertations & Projects

Purpose: This randomized controlled study quantitatively investigated whether providing oral hygiene instruction (OHI), through texting images and videos, affected oral hygiene status in orthodontic patients.

Materials and Methods: Sixty patients between 13-21 years of age, with visible plaque and used a smart phone, were recruited from the Graduate Orthodontic Clinic at Loma Linda University. Once recruited (T1), an initial survey was completed, MBI and OPI were recorded, and OHI was given. Subjects were randomly distributed into either a control or experimental group. The experimental group received OHI texts weekly, whereas the control group did not. After 3 months …

Association Of Nurses’ Sanctification Of Work With Work-Related Outcomes And Patient Satisfaction, Hazel M. Ada

Loma Linda University Electronic Theses, Dissertations & Projects

Nurses working in hospitals face many intrinsic stressors, including widespread job dissatisfaction, burnout, and frustration. These challenges, in turn, may affect patient care. Nursing often attracts individuals who wish to serve others, and some may find the expression of spirituality on the job helpful in finding meaning, satisfaction, and value in their work (Kociszewski, 2004). Sanctification of work (SoW) is a promising facet of spirituality defined by researchers as an individual’s experience of their work as a manifestation of God or sacred qualities that affects their effectiveness and engagement on the job (Walker, Jones, Wuensch, Aziz, and Cope, 2008). In …

Comparison Of Maxillary Sinus Dimensions And Volumes On Cbct And 3t Mr Images, Cara Hodgson

Loma Linda University Electronic Theses, Dissertations & Projects

Objective: This study compared the height, width, length, and volume of the maxillary sinus in Magnetic Resonance Imaging (MRI) and Cone-Beam Computed Tomography (CBCT).

Methods: Eleven human subjects participated in the study (mean age of 14y7m). One CBCT scan and one MRI scan were performed on each patient. CBCT images were captured with an 18 x16 inch field of view that covered the whole head. Contiguous sagittal MR images of the whole head were produced using a 3.0T imaging system with a T1-weighted 3D imaging sequence and isotropic resolution of 1.0 x1.0 x1.0 mm. Images were imported as …

Accuracy Of Surface Area And Volume Measurements Of Teeth Determined From Cbct, Joseph Hourany

Loma Linda University Electronic Theses, Dissertations & Projects

Objective: This study compared surface area and volume measurements made from 3D scans of physical teeth and segmented teeth taken from Cone-Beam Computed Tomography (CBCT) scans of a cadaver. Methods: A cadaver specimen was imaged by CBCT and all the teeth were subsequently extracted and cleaned of any tissue. Of all the extracted teeth, sixteen single-rooted teeth were included in this study. The extracted teeth were scanned with a 3M True Definition 3rd Generation intraoral scanner (3M, ESPE) to generate a stereolithography (STL) file to serve as the control for this study and their surface area and volume measurements as …

Biomechanics And Postural Control Characteristics In Low Back Pain Subgroups During Dynamic Task, Amjad Shallan

Loma Linda University Electronic Theses, Dissertations & Projects

Dynamic balance impairments are commonly observed in people with low back pain (LBP). People with LBP have reduced lumbopelvic stability and may exhibit spinal biomechanical and postural control changes during dynamic balance. A limited number of studies are available about the spinal kinematic and postural control changes during dynamic balance in people with nonspecific chronic low back pain (NSCLBP) subgroups. Therefore, the aim of this dissertation was to compare spinal kinematics and postural control between NSCLBP subgroups and healthy individuals during dynamic balance using a modified Star Excursion Balance Test (mSEBT). Eighteen NSCLBP subjects [9 active extension pattern (AEP), 9 …