Medicine and Health Sciences Commons^™

Double-Crested Cormorant Colony Effects On Soil Chemistry, Vegetation Structure And Avian Diversity, Leah Moran Veum, Brian S. Dorr, Katie C. Hanson-Dorr, R.J. Moore, Scott A. Rush

United States Department of Agriculture Wildlife Services: Staff Publications

Effects of Double-crested Cormorants (Phalacrocorax auritus) on vegetation, soil chemistry and tree health have been documented from their breeding colonies in the northern breeding grounds of Canada and the United States (U.S.) but not for areas within the southeastern United States where breeding activity is relatively novel. We compared vegetation and tree metrics such as structure diversity, and soil chemistry among colony islands, uninhabited islands, and abandoned colony islands within Guntersville Reservoir, a temperate forest ecosystem. Avian diversity and community structure were also quantified on these islands. Concentrations of potassium (K), phosphorus (P) and nitrate (NO3 −) in soil were …

School Of Nursing News, Georgia Southern University

Nursing: News & Publications (2013-2023)

• Nursing Faculty Present Research in Canada

Health & Kinesiology News, Georgia Southern University

Health Sciences & Kinesiology: News & Publications (2015-2023)

• Two Graduate Programs Receive National Ranking

Endovascular Management And The Risk Of Late Failure In The Treatment Of Ureteroarterial Fistulas, George Titomihelakis, Anthony Feghali, Tuong Nguyen, Dawn Salvatore, Paul Dimuzio, Babak Abai

Department of Medicine Faculty Papers

Ureteroarterial fistula (UAF) is a rare and life-threatening source of hematuria. A high index of suspicion is warranted for early diagnosis and timely intervention. Because of high perioperative risk and comorbidities in UAF patients, the endovascular approach has become preferred for repair. Infection can complicate this mode of therapy, and treatment with antibiotics is important. Herein we present five cases of secondary UAFs treated with stent graft alone or stent graft and embolization.

Antisense Oligonucleotide Modulators Of Serotonin Receptor 2c And Uses Thereof, Stefan Stamm, Manli Shen, Serene Josiah

Molecular and Cellular Biochemistry Faculty Patents

The present invention provides, among other things, oligonucleotide modulators of human 5′-HT2C receptor (HTR2C) and improved methods and composition for treating HTR2C-related diseases, disorders or conditions based on such modulators. In particular, oligonucleotides modulators according to the invention target specific regions in the Exon V/Intron V junction of the human HTR2C pre-mRNA and drive expression of HTR2C Vb splice isoform, leading to increased generation of non-edited strong HTR2C receptor and enhanced serotonin receptor activity.

A Competency Analysis Of Waterpark Aquatic Professionals, Christopher A. Crume, William D. Ramos

International Journal of Aquatic Research and Education

The purpose of this study was to further the knowledge base in the aquatics field and assist in the development of universal standards to ensure that competent managers are employed at waterpark type venues. Until recently, thanks in part to the establishment of the Model Aquatic Health Code (MAHC 2014), universal standards did not exist in aquatics. The development of standards in the field will help to ensure continuity in policies among all facility types, properly trained professionals, and ultimately safer environments for participants. Using a pair of five-point Likert scales to sample 600 aquatic professionals, this study sought to …

Excision Repair Cross-Complementing Group-1 (Ercc1) Induction Kinetics And Polymorphism Are Markers Of Inferior Outcome In Patients With Colorectal Cancer Treated With Oxaliplatin., Devika Rao, Atrayee Basu Mallick, Titto Augustine, Cecilia Daroqui, Jeeshan Jiffry, Amartej Merla, Imran Chaudhary, Raviraja Seetharam, Arjun Sood, Srikanth Gajavelli, Santiago Aparo, Lakshmi Rajdev, Andreas Kaubisch, Jennifer Chuy, Abdissa Negassa, John M. Mariadason, Radhashree Maitra, Sanjay Goel

Department of Medical Oncology Faculty Papers

Background: ERCC1, a component of nucleotide excision repair pathway, is known to repair DNA breaks induced by platinum drugs. We sought to ascertain if ERCC1 expression dynamics and a single nucleotide polymorphism (SNP) rs11615 are biomarkers of sensitivity to oxaliplatin therapy in patients with colorectal cancer (CRC).

Methods: Western blot and qPCR for ERCC1 expression was performed from PBMCs isolated from patients receiving oxaliplatin-based therapy at specified timepoints. DNA was also isolated from 59 biorepository specimens for SNP analysis. Clinical benefit was determined using progression free survival (PFS) for metastatic CRC.

Results: ERCC1 was induced in PBMC in response to …

Sex Differences In Fatigability And Recovery Relative To The Intensity–Duration Relationship, Paul Ansdell, Paul Ansdell, Callum G. Brownstein, Jakob Škarabot, Kristy M. Hicks, Glyn Howatson, Kevin Thomas, Sandra K. Hunter, Stuart Goodall

Exercise Science Faculty Research and Publications

Females are less fatigable than males during isometric exercise at intensities relative to maximal voluntary contraction (MVC); however, whether a sex difference in fatigability exists when exercise is prescribed relative to a critical intensity is unknown. This study established the intensity–duration relationship, and compared fatigability and recovery between sexes following intermittent isometric contractions normalised to critical intensity. Twenty participants (10 females) completed four intermittent isometric knee extension trials to task failure to determine critical intensity and the curvature constant (W′), followed by fatiguing tasks at +10% and −10% relative to critical intensity. Neuromuscular assessments were completed at baseline …

The Role Of Skeletal Muscle In Maintaining Vitamin D Status In Winter, Rebecca S. Mason, Mark S. Rybchyn, Myriam Abboud, Tara C. Brennan-Speranza, David R. Fraser

All Works

© 2019 American Society for Nutrition. The status of vitamin D is determined mainly by its formation in skin by the photochemical action of solar UVB light (wavelength 290-320 nm) on the precursor 7-dehydrocholesterol. Because of seasonal variation in intensity of solar UV light, vitamin D status falls in winter and rises in summer. It has been presumed that there is no functional store of vitamin D. Thus, to avoid deficiency, a nutritional supply would be required in winter. However, there is now evidence that the main circulating metabolite of vitamin D, 25-hydroxyvitamin D, accumulates in skeletal muscle cells, which …

Change In Motherhood Status And Fertility Problem Identification: Implications For Changes In Life Satisfaction, Arthur L. Greil, Julia Mcquillan, Andrea R. Burch, Michele H. Lowry, Stacy Tiemeyer, Kathleen S. Slauson-Blevins

Department of Sociology: Faculty Publications

Objective: To determine whether the association between changes in life satisfaction and becoming a mother (or not) depends on fertility problem identification status.

Background: Evidence and symbolic interactionist theory suggest that, for women who initially perceive a fertility barrier, gaining the valued identity “mother” should be associated with increases and continuing to face a blocked goal (i.e., not becoming a mother) should be associated with decreases in life satisfaction.

Method: This study used the nationally representative two-wave National Survey of Fertility Barriers to conduct a change-score analysis with chained multiple imputation. The focal dependent variable was change in life satisfaction. …

Pharmacotherapeutic Study Of Antiretroviral Therapy For Hiv/Aids Patients At The Federal Medical Centre, Owo, Ondo State, Nigeria, Isiaka Adebowale Ayeni Pharm., Adelanwa Oludele Itiola Prof, Tajudeen Temitayo Adebayo Dr.

Library Philosophy and Practice (e-journal)

A 6-12 months retrospective study is made of HAART utilization in cases of HIV/AIDS patients at Federal Medical Centre, Owo, Nigeria. The objective to evaluate the rational pharmacotherapeutic approach to the management of the retroviral disease. Sixty two (62) antiretroviral drug-naive HIV/AIDS patients, which comprise of (19) 30.65% males with a mean age of 37.15±8.55 years and (43) 69.35% females with a mean age of 35.68±9.75 years case files are reviewed. The data used for this study was extracted from the clinical records of the Hospital. Sixty six percent of the patients are at World Health Organization (WHO) clinical stage …

Ada News - 09/16/2019, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

What's Happening: September 16, 2019, Maine Medical Center

What's Happening

No abstract provided.

Sociodemographic And Health Status Characteristics Of Maine's Newly Eligible Medicaid Beneficiaries [Data Brief], Zachariah T. Croll Mph, Erika C. Ziller Phd, Barbara Leonard Mph

Medicaid

This data brief identifies key characteristics of groups who will gain access through MaineCare expansion. Researchers Croll and Ziller at the University of Southern Maine, along with Leonardson of the Maine Health Access Foundation present a statistical analysis of uninsured non-elderly adults age 18 – 64 with no children and lower incomes, the population newly eligible for MaineCare through expansion. Drawing from five years of data from Maine’s Behavioral Risk Factor Surveillance System, the report addresses sociodemographic characteristics, health status, and access to care. The survey indicates that those who are likely eligible for expanded MaineCare coverage are twice as …

The Huntingtin Inclusion Is A Dynamic Phase-Separated Compartment, Fahmida Aktar, Chakkapong Burudpakdee, Mercedes Polanco, Sen Pei, Theresa C. Swayne, Peter N. Lipke, Lesley Emtage

Publications and Research

Inclusions of disordered protein are a characteristic feature of most neurodegenerative diseases, including Huntington’s disease. Huntington’s disease is caused by expansion of a polyglutamine tract in the huntingtin protein; mutant huntingtin protein (mHtt) is unstable and accumulates in large intracellular inclusions both in affected individuals and when expressed in eukaryotic cells. Using mHtt-GFP expressed in Saccharomyces cerevisiae, we find that mHtt-GFP inclusions are dynamic, mobile, gel-like structures that concentrate mHtt together with the disaggregase Hsp104. Although inclusions may associate with the vacuolar membrane, the association is reversible and we find that inclusions of mHtt in S. cerevisiae are not taken …

Continuation Of Angiotensin Converting Enzyme Inhibitors On The Day Of Surgery Is Not Associated With Increased Risk Of Hypotension Upon Induction Of General Anesthesia In Elective Non-Cardiac Surgeries., U. Yoon, A. J. Setren, A. Chen, T. Nguyen, M. C. Torjman, T. L. Kennedy

Department of Anesthesiology Faculty Papers

No abstract provided.

Autophagy Modulation As A Treatment Of Amyloid Diseases, Zoe Mputhia, Eugene Hone, Timir Tripathi, Tim Sargeant, Ralph Martins, Prashant Bharadwaj

Research outputs 2014 to 2021

Amyloids are fibrous proteins aggregated into toxic forms that are implicated in several chronic disorders. More than 30 diseases show deposition of fibrous amyloid proteins associated with cell loss and degeneration in the affected tissues. Evidence demonstrates that amyloid diseases result from protein aggregation or impaired amyloid clearance, but the connection between amyloid accumulation and tissue degeneration is not clear. Common examples of amyloid diseases are Alzheimer's disease (AD), Parkinson's disease (PD) and tauopathies, which are the most common forms of neurodegenerative diseases, as well as polyglutamine disorders and certain peripheral metabolic diseases. In these diseases, increased accumulation of toxic …

Treatment Patterns Among Adults And Children With Membranous Nephropathy In The Cure Glomerulonephropathy Network (Curegn)., Michelle M. O'Shaughnessy, Jonathan P. Troost, Andrew S. Bomback, Michelle A. Hladunewich, Isa F. Ashoor, Keisha L. Gibson, Raed Bou Matar, David T. Selewski, Tarak Srivastava, Michelle N. Rheault, Amira Al-Uzri, Amy J. Kogon, Myda Khalid, Suzanne Vento, Neil S. Sanghani, Brenda W. Gillespie, Debbie S. Gipson, Chia-Shi Wang, Afshin Parsa, Lisa Guay-Woodford, Louis-Philippe Laurin

Manuscripts, Articles, Book Chapters and Other Papers

Introduction: The 2012 Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guidelines for Glomerulonephritis recommend that patients with membranous nephropathy (MN) at risk for progression receive immunosuppressive therapy (IST), usually after 6 months of observation. A cyclophosphamide (CYC) or calcineurin inhibitor (CNI)-based regimen is recommended as first-line IST. However, the extent to which KDIGO recommendations are adopted in practice remains largely unknown.

Methods: We evaluated prescribing practice among patients with primary MN (diagnosed 2010-2018) enrolled in the Cure Glomerulonephropathy Network (CureGN) cohort study. We also evaluated the availability of testing for phospholipase A2 receptor (PLA2R) in the contemporary era.

Results: …

Medical School Watercooler Newsletter - September 15, 2019, Lindsey Lyle

Watercooler Newsletter

This is the September 15, 2019 edition of the Frederick P. Whiddon College of Medicine's Newsletter - Watercooler.

Contents Include:

Pediatric intensivist joins USA College of Medicine faculty

Medical Spanish Interest Group and SRFC care for Latino immigrant population

Register Now: Obstetrics and Gynecology Conference

Med School Café video online: "What Is Urogynecology?"

Multispectral Tracing In Densely Labeled Mouse Brain With Ntracer, Douglas H Roossien, John M Webb, Cristina Mazuski, Erik D Herzog, Et Al.

2010-2019 OA Pubs

SUMMARY: This note describes nTracer, an ImageJ plug-in for user-guided, semi-automated tracing of multispectral fluorescent tissue samples. This approach allows for rapid and accurate reconstruction of whole cell morphology of large neuronal populations in densely labeled brains.

AVAILABILITY AND IMPLEMENTATION: nTracer was written as a plug-in for the open source image processing software ImageJ. The software, instructional documentation, tutorial videos, sample image and sample tracing results are available at https://www.cai-lab.org/ntracer-tutorial.

SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

Energy Cost Of Land And Shallow Water Walking In Females Who Are Overweight And Obese, Jacquelyn N. Zera, Elizabeth F. Nagle, Bethany B. Gibbs, John P. Abt, John M. Jakicic

International Journal of Aquatic Research and Education

Nineteen overweight or obese females completed three 10-minute experimental trials including a self-selected pace shallow water walking trial, a matched heart rate response land walking trial, and a self-selected pace land walking trial. Energy expenditure (kcal·min^-1)was computed from expired gases assessed via indirect calorimetry. Results showed energy expenditure was lower (p= 0.046) during shallow water walking (6.46 ± 1.38 kcal·min^-1) compared to matched heart rate response land walking trial (7.26 ± 1.29 kcal·min^-1), with no significant difference in between shallow water and self-selected pace land walking (6.92 ± 1.61 kcal·min^-1). …

Imatinib Mesylate Effects On Zebrafish Reproductive Success: Gonadal Development, Gamete Quality, Fertility, Embryo-Larvae Viability And Development, And Related Genes, Nader Ahmadi, Seyed-Mohammadreza Samaee, Robert A. Yokel, Aliasghar Tehrani

Pharmaceutical Sciences Faculty Publications

Imatinib (IM) is a tyrosine kinase (TK) inhibitor (TKI) used to treat chronic myeloid leukemia. Clinical case reports and a few laboratory mammal studies provide inconclusive evidence about its deleterious effects on reproduction. The aim of the current study was to evaluate the potential of zebrafish to characterize IM-induced effects on reproduction and clarify IM effects on reproductive success. To this end, we exposed adult zebrafish to four concentrations of IM for 30 days followed by a 30-day depuration period. IM exposure caused a concentration-dependent, irreversible, suppression of folliculogenesis, reversible decrease in sperm density and motility, decreased fecundity and fertility, …

September 2019, Randy Curry, Cindy Brooks

RURAL ROCKS

Rural Rocks, the Rural Health Network newsletter by the SWOSU College of Pharmacy

Uncertainty Management Among Older Adults With Heart Failure, Carly Daley, Victor Cornet, Gauri Patekar, Swapnil Kosarabe, Davide Bolchini, Tammy Toscos Phd, Michael Mirro Md, Shauna Wagner, Elizabeth Martin, Romisa Rohani Ghahari, Ryan Ahmed, Amy Miller, Richard J. Holden

Health Services and Informatics Research

Heart failure (HF) is a complex chronic illness that affects the older adult population, requiring medical therapy and day-to-day management to prevent worsening and exacerbation. Patients with HF are often treated with cardiac implanted electronic devices (CIEDs) which capture diagnostic and predictive parameters for HF. In this work we explore how patients would respond to receiving data from an implanted device, using a fictitious scenario interview method with 24 older adults with HF. We applied an uncertainty management lens to better understand how patients face uncertain outcomes and integrate novel data into their decision making. The findings provide insight into …

Social Determinants Of Health And Hiv/Aids In Florida, Alane C. Ertel, Robert J. Zeglin

Florida Public Health Review

As of 2016, there were reported to be 135,986 people living with HIV/AIDS (PLWH) in Florida alone, and its cities lead the nation’s incidence rates at around 5,000 new HIV diagnoses annually. Using a few social determinants of health (SDH) associated with deaths of despair (DOD), this paper aims to connect HIV rates to SDH to gain more understanding of how SDH can aid in the alleviation of HIV through public health policy and social change. Methods: This analysis evaluated the predictive ability of the SDH: Education, Insurance, Race, and RaceXEducation for HIV incidence in Florida using regression analysis. Results: …

Middle East Respiratory Syndrome On Health Information Websites: How Much Credible They Are?, Shahabedin Rahmatizadeh, Saeideh Valizadeh-Haghi, Arefeh Kalavani, Nadereh Fakhimi

Library Philosophy and Practice (e-journal)

Background: The most recent MERS outbreak has raised questions about prevention and symptoms since there is currently no vaccine to prevent MERS. People can help protect themselves from this illness by taking everyday preventive actions. To do so, it is helpful to get medical information on the Internet about this illness. Regarding the importance of ensuring the provision of accurate online information, the aim of this study was to assess the credibility of health websites about MERS by using HONcode tool.

Materials and methods: The term “MERS” was searched in Google, Yahoo, and Bing and the first three pages …

Osteoarthritis: Natural Supplements For Joint Health, Katherine Salay, Kimberly Gathers, Lindsey Mcclish, Lisa Vranekovic, Kristen Seaman, Ryan W. Naseman

Pharmacy and Wellness Review

An estimated 46 million adults in the U.S. are affected by arthritis, with osteoarthritis (OA) being the most common. Due to the limited pharmacologic therapy available to treat this condition, many patients are turning to dietary supplements to relieve their symptoms. Some of the most popular supplements available for the treatment of OA are glucosamine, chrondroitin and methylsulfonylmethane (MSM), but many less studied products are also available. Due to limited evidence of efficacy, it is difficult to make a strong recommendation for any of these products; however, pharmacists must be able to educate the patients that choose to use these …

The Importance Of Early Diagnosis And Treatment Of Postpartum Depression, Sarah E. Drake, Alison L. Huet, Tana M. Peterman, Jamie L. Drees, Robert D. Raiff

Pharmacy and Wellness Review

Postpartum depression (PPD) is a major depressive episode following childbirth that can have serious consequences affecting the family. Consequences range from marital problems and issues with child development to maternal suicide and infantcide. Depression in mothers can lead to cognitive and social impairment in the child as well as paternal postpartum depression in the father. Due to the severity of these problems, it is important to diagnose and treat mothers as soon as possible. There are several symptoms that are evident in mothers suffering from PPD that lead to diagnosis. Symptoms are similar to those of major depressive episodes, but …

A Novel Approach To Treating Alzheimer's Disease, Kristen Quertinmount, Breanne Rizzo, Caitlin Swann, Lindsey Coram, Mary Klein, Whitney N. Detillion

Pharmacy and Wellness Review

No abstract provided.

Prescription Drug Abuse: The Pharmacist's Occupational Hazard, Brieann J. Miller, Cynthia C. Nguyen, Joshua P. Stevens, Nicholas J. Edmonds, Ryan W. Naseman, Michael M. Milks

Pharmacy and Wellness Review

Prescription drug abuse within the profession of pharmacy is a rising threat that must be addressed. While familiarity of drugs, work-related stress, family history and enabling may contribute to addiction disorders, chemical impairment by the pharmacist can posse serious risks to patient care. Help is available for the struggling pharmacist in the form of treatment facilities and support networks for recovery.