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Full-Text Articles in Medicine and Health Sciences

Evaluating A Blood Warming Device For Packed Red Blood Cell Transfusions To Decrease Hypothermia In Very Preterm Infants: A Randomised Control Trial Protocol, Kayla C. Everhart Phd, Rn, Michael D. Wirth Msph, Phd, Face, Victor N. Iskersky, Robin B. Dail Phd, Rn, Faan Dec 2025

Evaluating A Blood Warming Device For Packed Red Blood Cell Transfusions To Decrease Hypothermia In Very Preterm Infants: A Randomised Control Trial Protocol, Kayla C. Everhart Phd, Rn, Michael D. Wirth Msph, Phd, Face, Victor N. Iskersky, Robin B. Dail Phd, Rn, Faan

Publications

Background: This protocol describes a study to test a commercial blood warming device in warming blood transfusions to prevent hypothermia associated with packed red blood cell (PRBC) transfusions in very preterm infants. Objectives: Very preterm infants receiving blood transfusions warmed by a commercial blood warmer will have less central body hypothermia post transfusion (abdominal temperatures < 36.5°C) and/or a higher mean abdominal temperature for the hour after the transfusion is complete compared to those receiving blood transfusions by standard of care. This trial has been registered with Clinicaltrials.gov (trial number NCT05170633). Methods: In this trial, which is funded by The Gerber Foundation and adhered to the SPIRIT2013 checklist, 140 very preterm infants with an order to receive PRBCs will be randomised into a standard of care group to receive one PRBC transfusion over 3 h with blood in a syringe at room temperature or into the intervention group to receive one PRBC transfusion over 3 h using a Hotline® Blood and Fluid Warmer. Abdominal skin temperatures will be measured every minute through a blood transfusion using a skin thermistor and datalogger. Data analysis: Descriptive statistics will be computed for each group to compare demographics and all infant pre-, during, and post-transfusion body temperatures. A student t-test will be used to compare the groups on mean post-transfusion temperatures as a primary outcome variable. To examine thermal change over time between the two groups, linear mixed models with a random intercept will be utilised. Results: This trial began in January 2022, in a South Carolina neonatal intensive care unit and is ongoing. Discussion: This RCT will determine if warming PRBC transfusions will prevent hypothermia in preterm infants during and after blood transfusions. Results from this trial will be used to design national standards for blood transfusions in preterm infants to decrease morbidity and mortality.


Public Health Trade-Offs During A Pandemic: Mobility Decline And Hypertension Risk In India, Arpita Khanna, Tomoki Fujii Dec 2025

Public Health Trade-Offs During A Pandemic: Mobility Decline And Hypertension Risk In India, Arpita Khanna, Tomoki Fujii

Research Collection School Of Economics

The Covid pandemic dramatically altered patterns of daily life, particularly through widespread declines in mobility due to lockdowns and social distancing measures. While the economic and epidemiological effects of these restrictions have been widely studied, their broader health implications remain underexplored. This paper investigates the relationship between mobility decline during the Covid pandemic and hypertension outcomes in India. Leveraging district-level variation in mobility from Google Community Mobility Reports and health data from the 2019–2021 Indian Demographic and Health Survey (DHS), we find that a 1 percentage point reduction in mobility over the 30 days prior to interview is associated with …


Addressing Nursing Student Burnout Through Mindfulness And Zen Den At University Of The Pacific, Jeremy Seaton, Tanairi Ingram, Natalia Zelayandia Dec 2025

Addressing Nursing Student Burnout Through Mindfulness And Zen Den At University Of The Pacific, Jeremy Seaton, Tanairi Ingram, Natalia Zelayandia

ELMSN E-Portfolio. A collection of Scholarly and Creative Works

Background:

Burnout among nursing students is a critical issue that negatively impacts academic performance, mental well-being, and long-term professional retention. Entry-Level Master of Science in Nursing students at University of the Pacific experience heightened stress due to rigorous coursework, clinical demands, and underdeveloped institutional mental health support.

Aim:

This Quality Improvement project aimed to reduce stress and strengthen emotional resilience among nursing students through Mindfulness-Based Stress Reduction education and the creation of a peer-supported wellness space, the “Zen Den.”

Methods:

A pre- and post-intervention design was implemented, utilizing surveys to measure mindfulness knowledge, attitudes toward self-care, and stress awareness. Zen …


Enhancing Pediatric Sun Safety: A Parent-Focused Intervention In El Dorado County, Ashley Riley, Calvin Nauer, Alaina Godwin Dec 2025

Enhancing Pediatric Sun Safety: A Parent-Focused Intervention In El Dorado County, Ashley Riley, Calvin Nauer, Alaina Godwin

ELMSN E-Portfolio. A collection of Scholarly and Creative Works

Background:

Childhood ultraviolet (UV) exposure is the most significant modifiable risk factor for skin cancer, yet proper sun protection remains inconsistently practiced by parents. In El Dorado County, California, where high altitude and intense sun exposure amplify UV risk, knowledge gaps and misinformation persist despite resource availability. This quality improvement (QI) project aimed to strengthen parental knowledge, confidence, and modeling of sun-safe behaviors for their children through an evidence-based community education program.

Aim:
The goal of this QI initiative was to improve parental attitudes, self-efficacy, and photoprotective behaviors by implementing a three-part, nursing-led educational intervention focused on UV risk awareness, …


Utilizing An Artificial Intelligence And Machine Learning Model To Predict Colorectal Cancer Risk In American Samoa: A Pilot Study, Va’Atausili Tofaeono, Tulimalefoi Va’Ofanua, Ana Jane M. Bontjia, Siumukuka Fa’Aiuaso – Galea’I, Robert Gayapa, Eran Choman, Shawnda Schroeder Dec 2025

Utilizing An Artificial Intelligence And Machine Learning Model To Predict Colorectal Cancer Risk In American Samoa: A Pilot Study, Va’Atausili Tofaeono, Tulimalefoi Va’Ofanua, Ana Jane M. Bontjia, Siumukuka Fa’Aiuaso – Galea’I, Robert Gayapa, Eran Choman, Shawnda Schroeder

Indigenous Health Faculty Publications

Objective: This pilot study aimed to assess the feasibility of using an artificial Intelligence and machine learning (AI/ML) model to predict colorectal cancer (CRC) risk in American Samoa, where resource limitations and cultural barriers significantly hinder screening efforts. Methods: The AI/ML model used complete blood count (CBC) results, along with age and gender, to predict CRC risk. A retrospective analysis was conducted on data from 6,025 individuals aged 50 and above from the Lyndon Baines Johnson Tropical Medical Center’s electronic health records. Of these, 62 participants were identified as high-risk for CRC based on the AI/ML model. The study also …


Mapping The Mortality-To-Incidence Ratios Of Alzheimer’S Disease And Related Dementias (Adrds): Evidence From The South Carolina Alzheimer’S Disease Registry, Eric Mishio Bawa, Daniel A. Amoatika, Margaret C. Miller Ms, Ph.D., Bankole A. Olatosi Ph.D., Lorie Donelle Phd, Rn, Fcan, Sue E. Levkoff Scd, Msw, Sm, James W. Hardin Ph.D., Xiaoming Li Ph.D., Leonardo Bonilha, Daniela B. Friedman Ph.D., Swann Arp Adams Ph.D., Ms, Face Dec 2025

Mapping The Mortality-To-Incidence Ratios Of Alzheimer’S Disease And Related Dementias (Adrds): Evidence From The South Carolina Alzheimer’S Disease Registry, Eric Mishio Bawa, Daniel A. Amoatika, Margaret C. Miller Ms, Ph.D., Bankole A. Olatosi Ph.D., Lorie Donelle Phd, Rn, Fcan, Sue E. Levkoff Scd, Msw, Sm, James W. Hardin Ph.D., Xiaoming Li Ph.D., Leonardo Bonilha, Daniela B. Friedman Ph.D., Swann Arp Adams Ph.D., Ms, Face

Publications

Introduction Mortality-to-incidence ratios (MIRs) are useful in assessing disease burdens and illustrating disparities. Unlike cancer, MIRs have not been applied to ADRDs. Therefore, we estimated and mapped the MIRs for ADRDs to show disparities in South Carolina. Methods Using data from the South Carolina Alzheimer’s Disease Registry (2017−2021), ADRD MIRs were calculated by demographic and geospatial characteristics. To account for the influence of the COVID-19 pandemic, data from 2015 to 2019 were also examined. MIRs were calculated as age-adjusted mortality rates divided by age-adjusted incidence rates. Results Overall, Black people and rural individuals consistently experienced higher MIRs, with the COVID-19 …


Building Adult-Gerontology Acute Care Nurse Practitioner Student Competencies For Telemental Health Treatment Through Simulation, Amy Dievendorf Dnp, Aprn, Fnp-Bc, Agacnp-Bc, Phyllis Raynor Phd, Aprn, Pmhnp-Bc, Beverly Baliko Phd, Rn, Pmhnp-Bc, Abbas Tavakoli Drph, Mph, Me Dec 2025

Building Adult-Gerontology Acute Care Nurse Practitioner Student Competencies For Telemental Health Treatment Through Simulation, Amy Dievendorf Dnp, Aprn, Fnp-Bc, Agacnp-Bc, Phyllis Raynor Phd, Aprn, Pmhnp-Bc, Beverly Baliko Phd, Rn, Pmhnp-Bc, Abbas Tavakoli Drph, Mph, Me

Publications

Depressive disorders are common mental health conditions that are often undiagnosed or undertreated. Adult-Gerontology Acute Care Nurse Practitioners (AGACNPs) are educated in the management of acute and critically ill patients but are often uncomfortable identifying and treating mental health conditions. Telehealth instruction is useful in mental healthcare and is required as part of the AGACNP’s efficient patient care competencies. This article reports findings from a mental health-focused telehealth instructional activity integrated into an existing AGACNP curriculum. This instructional activity was designed to introduce students to telehealth delivery and build AGACNP competencies using telehealth technology to assess patients with depressive mood …


Improving Early Detection Of Suicidal Ideation Through Routine Screening In Adults With General Anxiety Disorder, Brittanie N. Bush Dec 2025

Improving Early Detection Of Suicidal Ideation Through Routine Screening In Adults With General Anxiety Disorder, Brittanie N. Bush

Doctor of Nursing Practice

Suicide is a leading cause of death in the United States, with anxiety and depression recognized as independent risk factors for suicidal ideation (Centers for Disease Control and Prevention, 2024 September 26; Grant et al., 2023; Li et al., 2022; Moon et al., 2025; Wiebengo et al., 2021). Incorporating valid screening tools like the General Anxiety Disorder-7 and the Columbia-Suicide Severity Rating Scale can help identify suicidal ideation early, enabling quicker provider intervention (Johnson et al., 2019; O’Connor et al., 2022). The purpose of this project was to implement the Columbia-Suicide Severity Rating Scale as a standardized screening tool for …


Presenteeism Among Health Care Personnel With Covid-19, James C. Crosby, Eliezer Santos Leon, Brian Chinnock, Karisa K. Harland, Anusha Krishnadasan, Nicholas M. Mohr, Ian D. Plumb, Melissa Briggs Hagen, Kelli Wallace, David A. Talan, Anne Zepeski, Tracy Young, Howard A. Smithline, Lilly C. Lee, Stephen C. Lim, Gregory J. Moran, Mark T. Steele, David G. Beiser, John P. Haran, Peter C. Hou, Brett Faine, Utsav Nandi, Walter A. Schrading, Anne Chipman, Frank Lovecchio, Alysia Powers, Lisandra Uribe, Kavitha Pathmarajah, Dean M. Hashimoto, Chloe Namias, Efrat Kean, Elizabeth Krebs, Amy Stubbs, Sara Roy, Lucia Solis, Mary Mulrow, Nathan Graff, Jillian M Tozloski, William Mower, Jacqueline Caldera, Michelle Huber, Jacob Hampton, Abigail Lopes, Katherine Elkort, Stephanie A. Eucker, Carla Kingsbury, Jonathan Femling, Silas Bussmann, Jane Yee, Joseph Stuppy, Richard E. Rothman, Gaby Dashler, Marcel E. Curlin, Mastura Wahedi, Laurie Kemble Dec 2025

Presenteeism Among Health Care Personnel With Covid-19, James C. Crosby, Eliezer Santos Leon, Brian Chinnock, Karisa K. Harland, Anusha Krishnadasan, Nicholas M. Mohr, Ian D. Plumb, Melissa Briggs Hagen, Kelli Wallace, David A. Talan, Anne Zepeski, Tracy Young, Howard A. Smithline, Lilly C. Lee, Stephen C. Lim, Gregory J. Moran, Mark T. Steele, David G. Beiser, John P. Haran, Peter C. Hou, Brett Faine, Utsav Nandi, Walter A. Schrading, Anne Chipman, Frank Lovecchio, Alysia Powers, Lisandra Uribe, Kavitha Pathmarajah, Dean M. Hashimoto, Chloe Namias, Efrat Kean, Elizabeth Krebs, Amy Stubbs, Sara Roy, Lucia Solis, Mary Mulrow, Nathan Graff, Jillian M Tozloski, William Mower, Jacqueline Caldera, Michelle Huber, Jacob Hampton, Abigail Lopes, Katherine Elkort, Stephanie A. Eucker, Carla Kingsbury, Jonathan Femling, Silas Bussmann, Jane Yee, Joseph Stuppy, Richard E. Rothman, Gaby Dashler, Marcel E. Curlin, Mastura Wahedi, Laurie Kemble

Department of Medicine Faculty Papers

IMPORTANCE: Presenteeism-defined as continuing to work during an illness-poses a public health risk in the workplace and is especially hazardous within health care institutions where vulnerable patients may be exposed to nosocomial infections. Understanding the frequency and characteristics of health care personnel (HCP) who report presenteeism while ill with COVID-19 may help mitigate SARS-CoV-2 spread in hospitals and other health care institutions.

OBJECTIVES: To determine the frequency of presenteeism among HCP with symptomatic COVID-19, and to evaluate the demographic, occupational, and clinical factors associated with it.

DESIGN, SETTING, AND PARTICIPANTS: This is an observational cohort study that uses data from …


Endoscopic Retrograde Cholangiopancreatography And Primary Sclerosing Cholangitis: A Retrospective Study Of A High-Volume Program, Kristel Leung, Michael Youssef, Yasi Xiao, Catherine Streutker, Aliya Gulamhusein, Bettina Hansen, Natalia Calo, Gary May, Jeffrey Mosko, Gideon Hirschfield Dec 2025

Endoscopic Retrograde Cholangiopancreatography And Primary Sclerosing Cholangitis: A Retrospective Study Of A High-Volume Program, Kristel Leung, Michael Youssef, Yasi Xiao, Catherine Streutker, Aliya Gulamhusein, Bettina Hansen, Natalia Calo, Gary May, Jeffrey Mosko, Gideon Hirschfield

Division of Gastroenterology and Hepatology Faculty Papers

BACKGROUND: Endoscopic retrograde cholangiopancreatography (ERCP) is valuable in management of primary sclerosing cholangitis (PSC). Herein, we characterize individuals with PSC who underwent ERCP on-demand at a high-volume quaternary centre, with evaluation of pathology results and short-term postprocedural outcomes.

METHODS: This retrospective cohort study evaluated patients with PSC who underwent ERCP at St Michael's Hospital between April 2011 and July 2021. Chart review was conducted to collect clinical, procedural, and pathology data, and reported post-ERCP complications within 90 days. Logistic regression analyses were conducted to evaluate factors associated with post-ERCP complications and placement of a biliary stent.

RESULTS: One hundred and …


The Effect Of Exercise On Dynamic Balance And Walking Endurance In Patients With Relapsing Remitting Multiple Sclerosis: A Systematic Review And Meta-Analysis, Connor Gibson Dec 2025

The Effect Of Exercise On Dynamic Balance And Walking Endurance In Patients With Relapsing Remitting Multiple Sclerosis: A Systematic Review And Meta-Analysis, Connor Gibson

The Plymouth Student Scientist

Background: Multiple Sclerosis (MS) affects 2-3 million people worldwide, with relapsing remitting MS (RRMS) accounting for 75% of new cases. Exercise has been proposed to alleviate symptoms and enhance quality of life. This meta-analysis aims to evaluate the effect of exercise on dynamic balance and walking endurance in RRMS patients.

Methodology: A comprehensive PubMed search identified exercise interventions that specifically measured walking endurance via the 6-minute walk test (6MWT) and dynamic balance through the timed up-and-go (TUG) test. Mean and standard deviation values at baseline and post-intervention were extracted for analysis. For subgroup comparisons, interventions were classified as either lower …


Assessing Cognitive Performance And Comfort Under Simulated Mri Noise And Its Association With Autistic Like Traits, Jasmin Woodhouse Dec 2025

Assessing Cognitive Performance And Comfort Under Simulated Mri Noise And Its Association With Autistic Like Traits, Jasmin Woodhouse

The Plymouth Student Scientist

Magnetic Resonance Imaging (MRI) scanners produce noise levels between 65 and 130 decibels. This noise, alongside the broader sensory environment of the MRI, poses challenges for individuals with autism spectrum disorder (ASD). Noise exposure has been shown to impair task performance, increase errors, and affect brain activity. ASD traits are associated with decreased sound tolerance, including hyperacusis, misophonia, and phonophobia. In ASD, noisy environments disrupt inferior frontal gyrus function, impairing task response and brain connectivity. Given this, it’s crucial to understand how these sensory challenges specifically affect ASD experience and performance during MRI procedures. This study assesses cognitive performance and …


Detecting Concealed Autobiographical Information Using Feedback And Recognition P300 Erps. Exploring The Impacts Of Changed Feedback Proportions And Social Pressure In The Fcit, Cerys Parkinson-Johns, Grace Shillito, Callum Starr, Rosemary Wilmshurst Dec 2025

Detecting Concealed Autobiographical Information Using Feedback And Recognition P300 Erps. Exploring The Impacts Of Changed Feedback Proportions And Social Pressure In The Fcit, Cerys Parkinson-Johns, Grace Shillito, Callum Starr, Rosemary Wilmshurst

The Plymouth Student Scientist

The feedback concealed information test (fCIT) incorporates feedback on memory concealment performance within the classical CIT. Providing feedback facilitates the analysis of feedback related ERPs in addition to initial recognition related ERPs within each trial. Combining multiple ERPs aims to improve the reliability and efficiency of the test. The present study investigated the efficiency of combining recognition and feedback related P300 ERPs in detecting concealed birthdates in a personal item fCIT. Feedback proportions were altered to improve believability in feedback. Detection efficiencies using combined P300 amplitudes within this altered paradigm and the impacts of social pressures on feedback P300s were …


Examining The Correlation Between The Competing Values Framework And Other Scales Of Measure, Jesina Mistry Dec 2025

Examining The Correlation Between The Competing Values Framework And Other Scales Of Measure, Jesina Mistry

The Plymouth Student Scientist

Organisational culture is widely acknowledged as a critical determinant of performance and employee engagement, yet debates persist regarding how best to conceptualise and measure it. This study examines the construct validity of two widely used diagnostic tools: the Competing Values Framework (CVF) and the Organisational Culture Inventory (OCI). While the CVF has achieved broad application across sectors, questions remain regarding its empirical grounding and cross-cultural relevance. Using a quantitative, cross-sectional design, this research investigates the degree of convergence between CVF and OCI dimensions within a diverse UK-based sample spanning multiple industries and job levels. In addition, it incorporates three underexplored …


The Lived Experience Of Uk Students Transitioning To University With Type 1 Diabetes Mellitus, Emelia C. Steel Dec 2025

The Lived Experience Of Uk Students Transitioning To University With Type 1 Diabetes Mellitus, Emelia C. Steel

The Plymouth Student Scientist

Transitioning from secondary school to university is a high-risk period for managing type 1 diabetes among UK students. Canadian research identified limited systemic support during this period. However, there is a lack of qualitative insight into how students navigate this transition in the UK, where healthcare and education systems differ. This study addressed that gap through semi-structured interviews to understand what makes this transition particularly challenging and what support students would find most helpful. A purposive sample comprised seven participants aged 19–29 from four UK universities. Thematic analysis, guided by Braun and Clarke’s (2022) six-phase framework, identified three superordinate themes: …


Investigating Deception-Related Moral Conflict Using Electroencephalography (Eeg) Hyperscanning, Madie Ades Dec 2025

Investigating Deception-Related Moral Conflict Using Electroencephalography (Eeg) Hyperscanning, Madie Ades

The Plymouth Student Scientist

Amplitudes of the early Bereitschaftspotential (BP) and deceptive behaviour have been theorised to be modulated by moral conflict experienced when making deceptive decisions, as the decision to lie can depend upon our moral perceptions of what is right and wrong (Panasiti et al., 2014). However, most Electroencephalography (EEG) deception paradigms lack ecological validity by utilising instructed lying and failing to incorporate genuine social interaction (Ganis & Keenan, 2009) and therefore may fail to elicit genuine moral conflict. The present study combined hyperscanning EEG with a competitive two-player social game, where participants freely chose to respond accurately or deceptively for …


Dna Methylation Markers Of Insulin Resistance Surrogate Measures In The Atherosclerosis Risk In Communities (Aric) Study, Jeewoen Shin, Jan Bressler, Megan L Grove, Michael Brown, Elizabeth Selvin, James S Pankow, Myriam Fornage, Alanna C Morrison, Chloé Sarnowski Dec 2025

Dna Methylation Markers Of Insulin Resistance Surrogate Measures In The Atherosclerosis Risk In Communities (Aric) Study, Jeewoen Shin, Jan Bressler, Megan L Grove, Michael Brown, Elizabeth Selvin, James S Pankow, Myriam Fornage, Alanna C Morrison, Chloé Sarnowski

Faculty, Staff and Student Publications

Insulin resistance (IR) is a risk factor for cardiovascular diseases and type 2 diabetes. Associations between DNA methylation (DNAm) and IR have been less studied in African ancestry (AA) populations than those of European ancestry (EA). We aimed to identify associations between whole blood DNAm and IR in up to 1,811 AA and 964 EA participants from the Atherosclerosis Risk in Communities (ARIC) study. We quantified IR using three surrogate measures: the homeostasis model assessment of insulin resistance (HOMA-IR), the triglyceride-glucose index (TyG), and the triglyceride glucose-body mass index (TyG-BMI). We used ancestry-stratified linear regression models to conduct epigenome-wide association …


Association Of Epigenetic Age Acceleration And Mitochondrial Dna-Based Aging Metrics Provides Insights Into Mechanisms Of Aging-Related Diseases, Mengyao Wang, Yinan Zheng, Meng Lai, Emmanuel Saake, Xue Liu, Xiuqing Guo, Kent D Taylor, Tianxiao Huan, Roby Joehanes, Drew R Nannini, Kai Zhang, Nicole J Lake, Christina A Castellani, Stephen S Rich, Jerome I Rotter, Yongmei Liu, Laura M Raffield, April P Carson, Myriam Fornage, Jiantao Ma, Dan E Arking, Lifang Hou, Daniel Levy, Chunyu Liu Dec 2025

Association Of Epigenetic Age Acceleration And Mitochondrial Dna-Based Aging Metrics Provides Insights Into Mechanisms Of Aging-Related Diseases, Mengyao Wang, Yinan Zheng, Meng Lai, Emmanuel Saake, Xue Liu, Xiuqing Guo, Kent D Taylor, Tianxiao Huan, Roby Joehanes, Drew R Nannini, Kai Zhang, Nicole J Lake, Christina A Castellani, Stephen S Rich, Jerome I Rotter, Yongmei Liu, Laura M Raffield, April P Carson, Myriam Fornage, Jiantao Ma, Dan E Arking, Lifang Hou, Daniel Levy, Chunyu Liu

Faculty, Staff and Student Publications

Investigating the interplay between mitochondrial DNA (mtDNA) variations and epigenetic aging metrics may elucidate biological mechanisms associated with age-related diseases. We estimated epigenetic age acceleration (EAA) metrics from DNA methylation data and derived mtDNA metrics, including heteroplasmic variants and mtDNA copy number (mtDNA CN) from whole genome sequencing. Linear regressions and meta-analyses were conducted to assess associations between EAA and mtDNA metrics, adjusting for chronological age, self-identified sex, and other covariates in 6,316 participants (58% female, 41% non-White Americans). Mediation analysis was conducted to examine whether EAA mediated the relationship between mtDNA CN and metabolic traits. A higher burden of …


Hispanic Academic Leadership In The Health And Human Services, Gabriela Elizabeth Rangel Dec 2025

Hispanic Academic Leadership In The Health And Human Services, Gabriela Elizabeth Rangel

Theses and Dissertations

In the United States, there are 63.7 million Hispanics (U.S. Census Bureau, 2023), making them the largest racial or ethnic minority in the country. National data from 2019 indicates that only 6% of tenured faculty in the U.S. were Hispanic, highlighting a significant underrepresentation of leaders in academia (NCES, 2024). This study employed a phenomenological approach with purposeful sampling, utilizing semi-structured interviews with ten participants who had leadership experience in academia within Health and Human Services (H&HS). The interviews served to explore various aspects, such as what were their aspirations to become leaders, their perceptions of the characteristics and qualities …


A Picture Tells A Thousand Words—, But Ecg Signals Have More To Say, Ashley N. Gomez Dec 2025

A Picture Tells A Thousand Words—, But Ecg Signals Have More To Say, Ashley N. Gomez

Theses and Dissertations

With the increasing adoption of deep learning classification models in the medical domain, a critical challenge remains: achieving high predictive accuracy while maintaining clinical Inter-pretability. This study examines how model architecture, dataset origin, and the use of full versus subset data affect both classification performance and Interpretability in Electrocardiogram (ECG) signal analysis. ResNet18 is evaluated using an open-source ECG Image Dataset, thus a custom dataset derived from digitized ECG images. Post-hoc explainability methods, such as Integrated Gradients, are applied to determine which time steps have the most significant influence on model decisions. The findings demonstrate that model architecture and dataset …


Categorizing Weight Growth Of Infants Born Before 32 Weeks' Gestation Using The 2023 Postnatal Growth Charts For Preterm Infants., Fu-Sheng Chou, Hung-Wen Yeh, Crystal Hsueh, Jing Zhang, Maria Fe B. Villosis, Karine Barseghyan, Ashwini Lakshmanan, Reese H. Clark Dec 2025

Categorizing Weight Growth Of Infants Born Before 32 Weeks' Gestation Using The 2023 Postnatal Growth Charts For Preterm Infants., Fu-Sheng Chou, Hung-Wen Yeh, Crystal Hsueh, Jing Zhang, Maria Fe B. Villosis, Karine Barseghyan, Ashwini Lakshmanan, Reese H. Clark

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVE: To categorize growth and correlate growth categories with morbidities in infants born before 32 weeks of gestation.

STUDY DESIGN: This retrospective study categorized weight growth by correlating mean growth velocity (GV) with growth trajectory z-score changes (ΔGTZ ), as measured using 2023 Postnatal Growth Charts for Preterm Infants. The associations between weight categories and morbidities were assessed.

RESULTS: Weight gain of infants without morbidities was categorized into three groups based on correlating ΔGTZ with mean GV: slower ( ΔGTZ < -0.1), in-parallel ( ΔGTZ -0.1 to 0.3), and faster ( ΔGTZ > 0.3). The proportions of infants with and without morbidities in these categories were evaluated across two distinct cohorts, revealing similar …


Left And Right Ventricular Strain Mechanics In Fetal Tachyarrhythmia., Rukmini Komarlu, Janelle R. Noel-Macdonnell Phd, Neha Chellu, Geetha Haligheri Dec 2025

Left And Right Ventricular Strain Mechanics In Fetal Tachyarrhythmia., Rukmini Komarlu, Janelle R. Noel-Macdonnell Phd, Neha Chellu, Geetha Haligheri

Manuscripts, Articles, Book Chapters and Other Papers

Introduction: Assessment of myocardial function in fetuses with supraventricular tachyarrhythmia is challenging. Speckle-tracking echocardiography (STE) is a newer sensitive method to assess ventricular systolic function. We sought to assess left (LV) and right (RV) ventricular myocardial strain mechanics in fetuses with tachyarrhythmia and hypothesized that strain mechanics are impaired in this patient population even after conversion to sinus rhythm.

METHODS: This was a single-center retrospective review. LV and RV strain parameters were assessed using STE in tachyarrhythmia and after conversion to sinus rhythm and, compared to gestational age (GA), matched control fetuses in sinus rhythm.

RESULTS: Eighteen fetuses with tachyarrhythmia …


Adenovirus Types In Us Children Hospitalized Or Seen In The Emergency Department With Acute Respiratory Illness, 2016-2019., Tess Stopczynski, Varvara Probst, Adam Gailani, Justin Z. Amarin, Olla Hamdan, Haya Hayek, Laura S. Stewart, Herdi K. Rahman, Rangaraj Selvarangan, Jennifer E. Schuster, Christopher J. Harrison, Mary E. Moffatt, Marian G. Michaels, John V. Williams, Julie A. Boom, Leila C. Sahni, Vasanthi Avadhanula, Mary Allen Staat, Elizabeth P. Schlaudecker, Christina Quigley, Geoffrey A. Weinberg, Peter G. Szilagyi, Janet A. Englund, Eileen J. Klein, Aaron T. Curns, Heidi L. Moline, Ariana P. Toepfer, James D. Chappell, Andrew J. Spieker, Natasha B. Halasa Dec 2025

Adenovirus Types In Us Children Hospitalized Or Seen In The Emergency Department With Acute Respiratory Illness, 2016-2019., Tess Stopczynski, Varvara Probst, Adam Gailani, Justin Z. Amarin, Olla Hamdan, Haya Hayek, Laura S. Stewart, Herdi K. Rahman, Rangaraj Selvarangan, Jennifer E. Schuster, Christopher J. Harrison, Mary E. Moffatt, Marian G. Michaels, John V. Williams, Julie A. Boom, Leila C. Sahni, Vasanthi Avadhanula, Mary Allen Staat, Elizabeth P. Schlaudecker, Christina Quigley, Geoffrey A. Weinberg, Peter G. Szilagyi, Janet A. Englund, Eileen J. Klein, Aaron T. Curns, Heidi L. Moline, Ariana P. Toepfer, James D. Chappell, Andrew J. Spieker, Natasha B. Halasa

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Human adenovirus (HAdV) is a common cause of pediatric acute respiratory illness (ARI), contributing to 5-13% of cases worldwide. Clinical manifestations vary by HAdV species and type; therefore, delineating type-specific disease presentations and understanding severity of specific HAdV types' disease may help develop targeted interventions.

METHODS: We conducted a multicenter, prospective study within the New Vaccine Surveillance Network to characterize HAdV types. Children < 18 years old with ARI were enrolled in the emergency department or inpatient setting at 7 US children's hospitals from 1 December 2016 to 30 November 2019. Respiratory specimens were collected and tested for HAdV and other viruses. Subsequently, typing was conducted on HAdV specimens using single-plex real-time PCR assays targeting sequences in the hexon gene. Comparisons between HAdV types were performed to determine differences in characteristics and outcomes. Generalized linear mixed effects models were used to evaluate severity.

RESULTS: Among the 1843 HAdV-positive cases, 1402 specimens (76%) were typed. The most common types detected were HAdV-C1 (n = 439), HAdV-C2 (n = 393), and HAdV-B3 (n = 221). Children with HAdV-B7 (n = 78) …


Trends In Hospital Resource Use For Children With Complex Chronic Conditions., Nathaniel D. Bayer, Matthew Hall, Maria Osipovich, John M. Morrison, Christian D. Pulcini, Jana C. Leary, Joanna E. Thomson, Tamara D. Simon, Dennis Z. Kuo, Jeffrey D. Colvin, Eyal Cohen, Jay G. Berry Dec 2025

Trends In Hospital Resource Use For Children With Complex Chronic Conditions., Nathaniel D. Bayer, Matthew Hall, Maria Osipovich, John M. Morrison, Christian D. Pulcini, Jana C. Leary, Joanna E. Thomson, Tamara D. Simon, Dennis Z. Kuo, Jeffrey D. Colvin, Eyal Cohen, Jay G. Berry

Manuscripts, Articles, Book Chapters and Other Papers

IMPORTANCE: Despite a small prevalence, children with complex chronic conditions (CCCs) use substantial inpatient resources.

OBJECTIVE: To assess national trends in hospital discharges, bed days, and hospital charges for children with and without CCCs in the US from 2000 to 2022.

DESIGN, SETTING, AND PARTICIPANTS: This retrospective, repeated cross-sectional study used hospital discharge data from the Kids' Inpatient Database (KID) from the years 2000, 2003, 2006, 2009, 2012, 2016, 2019, and 2022 for US children aged 0 to 18 years, excluding uncomplicated newborn discharges.

EXPOSURE: Presence of 0, 1, 2, or 3 or more CCCs.

MAIN OUTCOMES AND MEASURES: Trends …


Hygiene Heroes: Strengthening Oral Hygiene To Reduce Central Line-Associated Bloodstream Infections In Pediatric Hematology/Oncology Patients, Sidney Clymer-Engelhart, Kirstie Shulman Dec 2025

Hygiene Heroes: Strengthening Oral Hygiene To Reduce Central Line-Associated Bloodstream Infections In Pediatric Hematology/Oncology Patients, Sidney Clymer-Engelhart, Kirstie Shulman

ELMSN E-Portfolio. A collection of Scholarly and Creative Works

Background: Central line-associated bloodstream infections (CLABSIs) impact pediatric patient outcomes, increasing mortality, hospital stays, and healthcare costs. At Sutter Medical Center Sacramento (SMCS), the CLABSI prevention bundle includes proper line care, dressing assessments, and hygiene practices, including twice-daily oral care, daily linen changes, and chlorhexidine gluconate (CHG) bathing. Sutter found their CLABSI bundle compliance at approximately 76–78%, with oral hygiene identified as the most frequent gap in care.

Aim: This quality improvement project, partnered with SMCS, targeted oral care compliance to enhance overall bundle adherence, strengthen staff-leadership communication, and ultimately reduce CLABSI rates in the hematology/oncology units. In a wider …


Fall Prevention In The Lobby Of The Emergency Department At Sutter Medical Center Sacramento, Tanya Rodriguez Duarte, Vaneza Espino, Roshni Hayer, Yajari Mendoza Dec 2025

Fall Prevention In The Lobby Of The Emergency Department At Sutter Medical Center Sacramento, Tanya Rodriguez Duarte, Vaneza Espino, Roshni Hayer, Yajari Mendoza

ELMSN E-Portfolio. A collection of Scholarly and Creative Works

Background: In 2024, Sutter Medical Center Sacramento (SMCS) reported 17 patient falls in the Emergency Department (ED) lobby, with 94% (n = 16) occurring in the triage area. Patients awaiting placement after triage are not classified as admitted and thus are not included in CMS’s inpatient fall reporting program. However, due to the known safety risk, SMCS ED leadership began tracking lobby falls locally and partnered with University of the Pacific nursing students to address this issue.. Aim: This quality improvement project aimed to reduce the incidence of falls in the ED lobby through enhanced fall risk identification, timely reassessment, …


The Kangaroo Care Project: Implementation Of Skin-To-Skin (Sts) In Sutter Medical Center, Sacramento, Neonatal Intensive Care Unit, Bianca Wong, Katherine Do, Martha Calero, Lydia Nambala Dec 2025

The Kangaroo Care Project: Implementation Of Skin-To-Skin (Sts) In Sutter Medical Center, Sacramento, Neonatal Intensive Care Unit, Bianca Wong, Katherine Do, Martha Calero, Lydia Nambala

ELMSN E-Portfolio. A collection of Scholarly and Creative Works

Background: Skin-to-skin contact, also known as kangaroo care or kangaroo mother care, is an intervention typically done after birth to promote physiologic stability, bonding, and breastfeeding.

Aim: The Kangaroo Care project aimed to increase the incidence of skin-to-skin contact in the neonatal intensive care unit at Sutter Medical Center, Sacramento.

Methods: A pre-survey was conducted to assess staff comfort with skin to skin. Interventions to increase skin-to-skin rates included staff e-learning, unplanned extubation mock codes, nurse champions, and a policy change to Sutter Medical Center, Sacramento’s handbook.

Results: TBD. Preliminary results indicated use of STS in the NICU and post-results …


Staying Ahead Of The Pressure: A Multimodal Intensive Care Unit Hospital-Acquired Pressure Injury Quality Improvement Project At Sutter Medical Center, Sacramento, Mijung Lim, Daniela Tobler, Raquel Youkhana Dec 2025

Staying Ahead Of The Pressure: A Multimodal Intensive Care Unit Hospital-Acquired Pressure Injury Quality Improvement Project At Sutter Medical Center, Sacramento, Mijung Lim, Daniela Tobler, Raquel Youkhana

ELMSN E-Portfolio. A collection of Scholarly and Creative Works

Background: Hospital-acquired pressure injuries (HAPIs) are a major quality and safety concern, particularly in the intensive care units (ICUs) where critically ill and immobile patients face elevated risk. At Sutter Medical Center Sacramento (SMCS), nine confirmed HAPIs and two under investigation were reported within the medical ICU, cardiac ICU, and neurosurgical ICU by May 2025, exceeding the hospital’s target and prompting a system-wide quality improvement initiative.

Aim: The aim of this project was to: (a) reduce ICU-acquired HAPIs to fewer than four cases per quarter by December 2025 and (b) increase nursing compliance with early and ongoing prevention strategies, including …


Improving Maternal Mental Health Awareness And Support In Perinatal Black And Latina Women, Jasman Hans, Lesly Carrillo, Kayla Huynh, Brianna Harrison Dec 2025

Improving Maternal Mental Health Awareness And Support In Perinatal Black And Latina Women, Jasman Hans, Lesly Carrillo, Kayla Huynh, Brianna Harrison

ELMSN E-Portfolio. A collection of Scholarly and Creative Works

Background: Black and Latina women in California experience disproportionately high rates of perinatal mental health disorders due to limited access to care, stigma, and systemic inequities.

Aim: In collaboration with BeMomAware, this Quality Improvement project aimed to enhance maternal mental health literacy among Black and Latino individuals in the Oak Park community of Sacramento. The project sought to increase awareness, knowledge, and access to culturally appropriate mental health resources through an educational video and community session.

Methods: Interventions included a short educational video and an in-person community session providing culturally relevant information about perinatal depression and anxiety disorders, available resources, …


Definition Of The 3d Position And Motion Status Of The Moving Heart Based On 2d Projections, Lawrence D. Orijuela Dec 2025

Definition Of The 3d Position And Motion Status Of The Moving Heart Based On 2d Projections, Lawrence D. Orijuela

Electronic Theses, Projects, and Dissertations

This thesis presents a novel application of deep learning to the estimation of pulmonary vein coordinates using X-ray image pairs from a FORBILD Thorax phantom derived motion dataset. A Siamese neural network was developed to predict the 3D coordinates of one pulmonary vein at a time, specifically the Right Superior Pulmonary Vein (RSPV), Left Superior Pulmonary Vein (LSPV), Left Inferior Pulmonary Vein (LIPV), or Right Inferior Pulmonary Vein (RIPV), based on two-dimensional projection images.

The input data consisted of over 1.6 million grayscale X-ray image pairs across 1331 virtual patients, each annotated with ground truth 3D coordinates. To manage memory …