Medicine and Health Sciences Commons^™

Mitochondrial Calcium Exchange Links Metabolism With The Epigenome To Control Cellular Differentiation., Alyssa A. Lombardi, Andrew A. Gibb, Ehtesham Arif, Devin W. Kolmetzky, Dhanendra Tomar, Timothy S. Luongo, Pooja Jadiya, Emma K. Murray, Pawel K. Lorkiewicz, György Hajnóczky, Elizabeth Murphy, Zoltan P. Arany, Daniel P. Kelly, Kenneth B. Margulies, Bradford G. Hill, John W. Elrod

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Fibroblast to myofibroblast differentiation is crucial for the initial healing response but excessive myofibroblast activation leads to pathological fibrosis. Therefore, it is imperative to understand the mechanisms underlying myofibroblast formation. Here we report that mitochondrial calcium (_mCa²⁺) signaling is a regulatory mechanism in myofibroblast differentiation and fibrosis. We demonstrate that fibrotic signaling alters gating of the mitochondrial calcium uniporter (mtCU) in a MICU1-dependent fashion to reduce _mCa²⁺ uptake and induce coordinated changes in metabolism, i.e., increased glycolysis feeding anabolic pathways and glutaminolysis yielding increased α-ketoglutarate (αKG) bioavailability. _mCa²⁺-dependent metabolic reprogramming leads …

A Community-Based Survey To Assess Knowledge, Attitudes, Beliefs And Practices Regarding Herpes Zoster In An Urban Setting, Nour A. Baalbaki, Joseph P. Fava, Melanie Ng, Ezinwanne Okorafor, Asad Nawaz, Wesley Chiu, Abdulbaset Salim, Raymond Cha, Paul E. Kilgore

Department of Pharmacy Practice

Introduction: In the USA, nearly one in three people will experience herpes zoster (HZ) in their lifetime. Underserved communities may be at even higher risk due to several factors, including access to healthcare, education, and co-morbid conditions. The purpose of this study was to investigate current knowledge, attitudes, beliefs and practices (KABP) relative to HZ and HZ vaccines in a large urban city.

Methods: A cross-sectional KABP survey was conducted via in-person interview among 381 participants aged ≥ 50 years in Detroit, MI, USA, from June to August 2018. Survey results were stratified into two groups [< 60 and ≥ 60 years of age (YO)] for comparison.

Results: Of the …

Patients Living With Hiv Infection Are Less Likely To Receive The Correct Statin Intensity For Cardiovascular Disease Risk Reduction, Jason J. Schafer, Pharmd, Mph, Roshni Emmons, Pharmd, Bcps, Nick V. Hastain, Pharmd, Todd Miano, Pharmd, Phd

College of Pharmacy Posters

• Patients living with HIV (PLWH) are at high risk for atherosclerotic cardiovascular disease (ASCVD)
• Eligible PLWH should receive statins for ASCVD risk reduction according to current guidelines
• Studies suggest that statins are underprescribed in PLWH, but comparisons to uninfected patients and assessments of statin intensity have not occurred

Objective

To determine the influence of HIV infection on appropriate statin prescribing for ASCVD risk reduction

Saliva Enhances Infection Of Gingival Fibroblasts By Herpes Simplex Virus 1., Yi Zuo, J Charles Whitbeck, Gabriel J Haila, Abraham A Hakim, Paul W Rothlauf, Roselyn J Eisenberg, Gary H Cohen, Claude Krummenacher

College of Science & Mathematics Departmental Research

Oral herpes is a highly prevalent infection caused by herpes simplex virus 1 (HSV-1). After an initial infection of the oral cavity, HSV-1 remains latent in sensory neurons of the trigeminal ganglia. Episodic reactivation of the virus leads to the formation of mucocutaneous lesions (cold sores), but asymptomatic reactivation accompanied by viral shedding is more frequent and allows virus spread to new hosts. HSV-1 DNA has been detected in many oral tissues. In particular, HSV-1 can be found in periodontal lesions and several studies associated its presence with more severe periodontitis pathologies. Since gingival fibroblasts may become exposed to salivary …

Recovery Success Through Combined Use Of Vivitrol And Counseling Versus Pharmacological Treatment Alone In Opiate-Addicted Patients, Ashley Estes

Doctoral Projects

The growing incidence of opiate addiction in the United States has been declared a public health emergency (Hargan, 2017). Vivitrol, a monthly injectable extended-release naltrexone, helps to block the cravings of opiates so patients can focus on changing their behavior and lifestyle. Counseling has been suggested as an effective adjunctive therapy when used concurrently with Vivitrol. This study is a retrospective chart review and aims to compare the outcomes between two groups of patients; one that receives the monthly Vivitrol injection plus attend regular counseling and one group, equal in size, that receives Vivitrol alone.

Better Teaching Means Better Learning: 45 Minutes, 100 Years Of Educational Psychology, And 4 Concepts You Can Apply Today, Cheryl Arndt

Department of Education

No abstract provided.

Exploring The Prevalence And Characteristics Associated With Weight Gain And Metabolic Changes In Plwh Who Are Virologically Suppressed On Antiretroviral Therapy And Switch To Integrase Inhibitor Containing Regimens, Matty Zimmerman, Joseph Desimone Jr., Md, Jason J. Schafer, Pharmd, Mph, Bcps-Aq Id, Bcidp, Aahivp

College of Pharmacy Posters

Objectives

• To determine the prevalence, extent and characteristics of weight gain among virologically suppressed PLWH whose ART has been switched to an INSTI-containing regimen
• To examine the presence of metabolic changes in PLWH who have been switched to INSTI-containing ART

Advanced Glycation End Products: Formation, Role In Diabetic Complications, And Potential In Clinical Application, Rujman Khan, Xin Yee Ooi, Matthew N. Parvus, Laura Valdez, Andrew Tsin

School of Medicine Publications

Hyperglycemic conditions and disruptions to glucose-regulating pathways lead to increased formation of highly reactive aldehydes, methylglyoxal and glyoxal, which react with certain arginine and lysine residues in proteins to form advanced glycation end products (AGEs). These AGEs damage the integrity of the retinal vasculature predominantly through two mechanisms: non-receptor-mediated damage, which pertains to the interaction with extracellular matrix and its functional properties, and receptor-mediated damage through AGE interactions with their receptors (RAGE) on pericytes and Muller cells. Damage occurring between AGE and RAGE potentially generates reactive oxygen species, inflammatory cytokines, and growth factors. Both mechanisms result in increased permeability of …

Impact Of Nurse Manager Peer Mentorship Program On Job Satisfaction And Intention To Stay, Tonya Roth, Diane Whitehead

Journal of Excellence in Nursing and Healthcare Practice

Nurse managers (NMs) play a vital role in patient outcomes by providing a stable work environment for teams. Numerous factors influence a NM’s job satisfaction and intent to remain in a job. The purpose of this project was to develop an evidence-based formal mentorship program for NMs in an effort to impact retention rates. A secondary purpose was to evaluate the impact that a formal mentorship program has on NMs’ job satisfaction and intent to stay. Across two hospitals in the Pacific Northwest, 15 NMs participated in a 6-month mentorship program. The program was guided by both the mentorship enactment …

Health Benefits Associated With An Employer-Sponsored Health Promotion Program With Device-Reported Activity, Ian Duncan, Wade Herndon, Xiyue Liao

Journal of Wellness

Background: As interest has grown in the effect of healthy behaviors on health outcomes, programs have been developed to incent healthy behavior. The growth of devices able to transmit information about program participant activities has allowed researchers to analyze physical activity (PA). We analyzed the relationship between positive changes in device-reported physical activity levels and changes in health-related variables in a longitudinal cohort of US based employees.

Methods: Exercise levels were measured and recorded by a device (such as a pedometer or heart-rate monitor) or gym visit and recorded by the health promotion program provider, The Vitality Group. The devices …

Spring 2019 College Of Health Studies Research Symposium Abstracts, Susan Lacey

Journal of Interprofessional Practice and Collaboration

No abstract provided.

Mentorship And Evidence Based Practice With Athletic Trainer Preceptors: An Overview, John Roberts Jr, Jessica R. Dolecheck Dr

Journal of Interprofessional Practice and Collaboration

Evidence-based practice is often acknowledged as important and has an understood value by health professional students and practitioners. The Commission for Accreditation of Athletic Training Education (CAATE) adopted and integrated five core competencies into the new 2020 accreditation standards for Athletic Training education programs which strongly advocate for the inclusion of EBP. Hence, athletic training educators should work to embed EBP into curricula and clinical experiences through strategic planning and assessment to ensure educational goals and patient outcomes support the vision put forth by the CAATE. Furthermore, training preceptors to provide appropriate mentorship to athletic training students related to EBP …

The Effect Of An Online Concussion Education Program On Knowledge Retention For High School Football Coaches, John D. Boudreaux, Jessica R. Dolecheck Dr

Journal of Interprofessional Practice and Collaboration

A quasi-experimental repeated measure design was used to investigate the effect of an online concussion education program on the knowledge retention among 37 high school football coaches over a 15-week period and whether any variables can successfully predict knowledge retention. Data were collected immediately following an online concussion education program and post 15-weeks using a valid and reliable concussion assessment tool consisting of three distinct subsections: signs and symptoms recognition, common concussion misconceptions, and scenario-based question. A 2-tailed dependent samples t-test was conducted to test knowledge retention, while a multiple linear regression analysis was performed to assess which coaching characteristics …

An Interdisciplinary Approach For Treating Children With Cerebral Palsy, Magen Keys, Connie Lewis

Journal of Interprofessional Practice and Collaboration

Cerebral Palsy (CP) is a neurological disorder that affects the brain and muscles, often causing motor and social delays. Children diagnosed with CP often require interdisciplinary care to promote quality of life and improved development of motor and social skills. Interdisciplinary teams made up of families, the patient, nurses and therapists allow for ongoing goal setting and communication of treatment plans. Each member of the team plays a significant role as they offer specialized services to enhance not only the patient’s physical development but also

the child’s ability to build social relationships, promote autonomy, and encourage independence.

An interdisciplinary approach …

Student Led Interprofessional Activities: A Case Of Collaboration Between Student National Pharmaceutical Association, Student Nursing Association, And The National Kidney Foundation, Alexis Horace, Roxie Stewart, Craig Lavespere

Journal of Interprofessional Practice and Collaboration

Purpose:

The purpose of this project is to describe the implementation of a student led Interprofessional education (IPE) event in collaboration with a national organization, and to describe the perception of interprofessional growth by student volunteers. This even was hosted by the Student National Pharmaceutical Association (SNPhA) and the Student Nursing Association (SNA) in collaboration with the National Kidney Foundation (NKF) Louisiana.

Methods:

SNPhA and the SNA collaborated with the NKF Louisiana to create an IPE event which took place September 29th, 2018 at the College of Pharmacy. A total of 16 student pharmacists and 16 nursing students participated in …

Prebriefing: An Effective And Efficient Strategy To Maximize Simulation Based Learning, Ashley Krebs, Susan Lacey

Journal of Interprofessional Practice and Collaboration

Developing and implementing effective teaching methods require careful planning and time-intensive implementation by nursing faculty and their leadership (Fey & Jenkins, 2015). This is especially true when introducing new strategies. Simulation-based learning (SBL) is one such strategy. SBL is an evidence-based approach that enhances student learning and promotes knowledge retention necessary to safely provide care for patients (Kirkman, 2013). However, the adoption and implementation of SBL is highly variable across schools of nursing and other disciplines (Hayden, 2010).

Interprofessional education (IPE) has made significant gains in the past decade with several disciplines mandated by accreditors to provide evidence of IPE …

Spring Into Health: An Interprofessional Education Health Fair, Savannah Parker, Cassie Crew, Savannah Posey

Journal of Interprofessional Practice and Collaboration

The Spring Into Health community health fair was an interprofessional education (IPE) event

hosted by the University of Louisiana Monroe (ULM) College of Pharmacy's Christian

Pharmacists Fellowship International (CPFI) organization. The event included the participation

of several student pharmacy groups, as well as the ULM nursing, dental hygiene, medical

laboratory science, and health studies departments. Every organization involved in the health fair

provided either a health screening or a health education topic to the community of Ouachita

Parish, which is located in northeastern Louisiana. The event was hosted at the Louisiana

Purchase Gardens and Zoo in Monroe, Louisiana, and took …

Collaborative Allied Health And Nursing Interprofessional Health Education: Beginning The Journey, Anita Hazelwood, Lisa Delhomme, Scott Sittig

Journal of Interprofessional Practice and Collaboration

The Allied Health and Nursing Departments within the College of Nursing and Allied Health Professions at the University of Louisiana at Lafayette have begun a journey towards interprofessional health education (IPE) with the vision of offering multiple IPE courses for the allied health and nursing students. The need for interprofessional education in the health professions has been recognized for many years. In 1998, the Pew Health Professions Commission identified the need for interdisciplinary teams as an endeavor to strive for in the 21st century. A variety of terms have been used to describe this pedagogic practice including shared learning, interprofessional …

Impact Of An Educational Intervention On Faculty To Faculty Incivility, Sandy Bailey

Journal of Interprofessional Practice and Collaboration

: Faculty –to- faculty incivility within schools of nursing is a growing problem. Incivility amongst nursing faculty has the potential to effect other nursing faculty, nursing students, the school of nursing, and increase the risk of harm to patients in the clinical setting. A common recommendation for addressing faculty-to-faculty incivility is an educational offering about civility, incivility, and methods to address incivility. Ideally, an educational intervention about incivility can decrease levels of incivility in nursing education thereby increasing the amount of civility within the organization. The purpose of the research was to measure the impact of an educational intervention on …

The Effects Of A Yoga Intervention, Karen Arrant

Journal of Interprofessional Practice and Collaboration

Sleep disturbance and stress in postmenopausal women pose physical, mental, and emotional health hazards. Researchers examined the effect of a yoga intervention on sleep, stress, anxiety, and depression in postmenopausal women. The study employed a randomized, controlled trial with: (1) a treatment group (yoga intervention) and (2) an attention-control group (health education). All participants completed three PROMIS® – Patient-Reported Outcomes Measurement Information System – tools and collected saliva samples before and after the eight-week intervention. The PROMIS® tools measured sleep, anxiety, and depression. Salivary alpha-amylase quantified sleep; salivary cortisol measured stress; and participants self-reported hours of sleep.

Thirty-one women completed …

Exposure To The Rxr Agonist Sr11237 In Early Life Causes Disturbed Skeletal Morphogenesis In A Rat Model, Holly Dupuis, Michael Andrew Pest, Ermina Hadzic, Thin Xuan Vo, Daniel B. Hardy, Frank Beier

Physiology and Pharmacology Publications

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Longitudinal bone growth occurs through endochondral ossification (EO), controlled by various signaling molecules. Retinoid X Receptor (RXR) is a nuclear receptor with important roles in cell death, development, and metabolism. However, little is known about its role in EO. In this study, the agonist SR11237 was used to evaluate RXR activation in EO. Rats given SR11237 from post-natal day 5 to post-natal day 15 were harvested for micro-computed tomography (microCT) scanning and histology. In parallel, newborn CD1 mouse tibiae were cultured with increasing concentrations of SR11237 for histological and whole-mount evaluation. …

Short Chain Fatty Acid -Butyrate Anti- Il-1 Β Induced Intestinal Inflammation By Regulating The Intestinal Barrier Function Related Genes In Neonatal Mice, Brittany Davis

Annual Student Research Poster Session

Necrotizing Enterocolitis (NEC) is a disease that causes excessive inflammatory necrosis within the intestines. It affects 10% of premature infants weighing under 1500 grams, and leads to increased morbidity and mortality, causing extensive expenditure of healthcare dollars. This disease triggers devastatingly painful symptoms within infants. Recent studies have shown that feeding infants breast milk rather than formula milk can help alleviate the painful inflammation of this disease.1 Moreover, supplementing a mother’s breast milk with probiotics has been shown to enhance this anti-inflammatory effect. Currently, the focus towards ameliorating NEC disease lies within determining the underlying mechanism of these findings. Seeing …

Association Of Histologic Disease Activity With Progression Of Nonalcoholic Fatty Liver Disease., David E Kleiner, Elizabeth M Brunt, Laura A Wilson, Cynthia Behling, Cynthia Guy, Melissa Contos, Oscar Cummings, Matthew Yeh, Ryan Gill, Naga Chalasani, Brent A Neuschwander-Tetri, Anna Mae Diehl, Srinivasan Dasarathy, Norah Terrault, Kris V Kowdley, Rohit Loomba, Patricia Belt, James Tonascia, Joel E Lavine, Arun J Sanyal

Articles, Abstracts, and Reports

Importance: The histologic evolution of the full spectrum of nonalcoholic fatty liver disease (NAFLD) and factors associated with progression or regression remain to be definitively established.

Objective: To evaluate the histologic evolution of NAFLD and the factors associated with changes in disease severity over time.

Design, Setting, and Participants: A prospective cohort substudy from the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) NAFLD Database study, a noninterventional registry, was performed at 8 university medical research centers. Masked assessment of liver histologic specimens was performed, using a prespecified protocol to score individual biopsies. Participants included 446 adults with NAFLD enrolled in …

Potential Causes Of Early Death Among Admitted Newborns In A Rural Tanzanian Hospital, Robert Moshiro, Jeffrey M. Perlman, Paschal Mdoe, Hussein Kidanto, Jan Terje Kvaløy, Hege L. Ersdal

Obstetrics and Gynaecology, East Africa

Background: Approximately 40,000 newborns die each year in Tanzania. Regional differences in outcome are common. Reviewing current local data, as well as defining potential causal pathways leading to death are urgently needed, before targeted interventions can be implemented

Objective: To describe the clinical characteristics and potential causal pathways contributing to newborn death and determine the presumed causes of newborn mortality within seven days, in a rural hospital setting.

Methods: Prospective observational study of admitted newborns born October 2014–July 2017. Information about labour/delivery and newborn management/care were recorded on data collection forms. Causes of deaths were predominantly based on clinical diagnosis. …

Novel Sphingomyelin Biomarkers For Brain Glioma And Associated Regulation Research On The Pi3k/Akt Signaling Pathway, Xiao-Hui Zhai, Jian Xiao, Jie-Kai Yu, Hong Sun, Shu Zheng

Chemistry and Biochemistry Faculty Research

Glioma is one of the most common malignant tumor types of the central nervous system. It is necessary to identify biomarkers and novel therapeutic targets for glioma. The purpose of the present study was to distinguish lipid biomarkers with differential expression patterns in glioma tissues and normal brain tissues by matrix assisted laser desorption/ionization (MALDI)‑imaging and MALDI‑time of flight (TOF)‑mass spectrometry (MS). Additionally, identification of lipid biomarkers was performed to describe novel therapeutic targets for glioma treatment. A total of six tissues from three patients with glioma and three control patients with traumatic brain injury were analyzed using UltrafleXtreme MALDI‑TOF/TOF. …

Automation Of Karl Fischer Titration For Animal Pharmaceutical Product Testing At Elanco Animal Health, Elizabeth L. Grubbs

Annual Student Research Poster Session

Ever wonder what doing research looks like in the context of working in industry? This summer I had the opportunity to work at Elanco Animal Health, the world’s third largest animal pharmaceutical company (and growing!) I worked in the Quality Control laboratories where products are tested before they are sent out the door. I did research to automate a process that checks for the water content of various animal health products. The water content of these products is important for many reasons including expiration dates and FDA requirements. The process that I automated is called Karl Fischer titration and is …

Shared Governance Effect On Nursing Outcomes, Beverly Phillippe

Graduate Theses, Dissertations, and Capstones

Introduction

The economy has made it necessary for hospitals to consolidate into integrated systems. Government and private insurance stipulations for reimbursement have become rigorous and dependent on quality and readmission rates. Hospital-acquired infections or injuries are no longer reimbursable (Underwood & Hayne, 2017). The changing landscape has been challenging for the healthcare worker, affecting morale, and in turn, patient care. It is essential for hospitals to perform at the highest level for patient outcomes and safety, in addition to creating healthy work environments for employees. Shared/Transformational Governance is key to developing top functioning hospitals. Involving the staff in decision making …

Validation Of A Miniaturized Permeability Assay Compatible With Crispr-Mediated Genome-Wide Screen., Claire Simonneau, Junning Yang, Xianguo Kong, Robert Kilker, Leonard Edelstein, Paolo Fortina, Eric R. Londin, Arie Horowitz

Cardeza Foundation for Hematologic Research

The impermeability of the luminal endothelial cell monolayer is crucial for the normal performance of the vascular and lymphatic systems. A key to this function is the integrity of the monolayer's intercellular junctions. The known repertoire of junction-regulating genes is incomplete. Current permeability assays are incompatible with high-throughput genome-wide screens that could identify these genes. To overcome these limitations, we designed a new permeability assay that consists of cell monolayers grown on ~150 μm microcarriers (MCs). Each MC functions as a miniature individual assay of permeability (MAP). We demonstrate that false-positive results can be minimized, and that MAP sensitivity to …

Catholicism In The Neonatal Context: Belief, Practice, Challenge, Hope, M. Therese Lysaught Phd

Institute of Pastoral Studies: Faculty Publications and Other Works

Roman Catholics comprise the largest single denomination in the United States and are the nation’s largest group of not-for-profit healthcare providers. Yet, there is little or no available literature to assist neonatal caregivers in understanding how religious beliefs and values might influence parents’ responses to the challenges posed by their newborn’s care. Equally, there is little or no available literature on the academic or pastoral side addressing questions of neonatal medicine from a theological perspective. This chapter addresses how Roman Catholic teachings might affect the ways in which parents and caregivers make treatment decisions. It examines the neonatal context in …

Association Of Β-Amyloid Burden With Sleep Dysfunction And Cognitive Impairment In Elderly Individuals With Cognitive Disorders., Jason C. You, Erica Jones, Devon E. Cross, Abigail C. Lyon, Hyunseung Kang, Andrew B. Newberg, Carol F. Lippa

Department of Neurology Faculty Papers

Importance: Evidence shows that sleep dysfunction and β-amyloid (Aβ) deposition work synergistically to impair brain function in individuals with normal cognition, increasing the risk of developing dementia later in life. However, whether Aβ continues to play an integral role in sleep dysfunction after the onset of cognitive decline in individuals with dementia is unclear.

Objective: To determine whether Aβ deposition in the brain is associated with subjective measures of sleep quality and cognition in elderly individuals with cognitive disorders.

Design, Setting, and Participants: A nested survey study was conducted at the Cognitive Disorders and Comprehensive Alzheimer Disease Center of Thomas …