Medicine and Health Sciences Commons^™

Statistical Multiscale Mapping Of Idh1, Mgmt, And Microvascular Proliferation Inhuman Braintumors From Multiparametric Mr And Spatially-Registered Core Biopsy, Jason G. Parker, Emily E. Diller, Sha Cao, Jeremy T. Nelson, Kristen W. Yeom, Chang Ho, Robert M. Lober

Pediatrics Faculty Publications

We propose a statistical multiscale mapping approach to identify microscopic and molecular heterogeneity across a tumor microenvironment using multiparametric MR (mp-MR). Twenty-nine patients underwent pre-surgical mp-MR followed by MR-guided stereotactic core biopsy. The locations of the biopsy cores were identified in the pre-surgical images using stereotactic bitmaps acquired during surgery. Feature matrices mapped the multiparametric voxel values in the vicinity of the biopsy cores to the pathologic outcome variables for each patient and logistic regression tested the individual and collective predictive power of the MR contrasts. A non-parametric weighted k-nearest neighbor classifier evaluated the feature matrices in a leave-one-out cross …

The Impact Of Grammar On Mentalizing: A Training Study Including Children With Autism Spectrum Disorder And Developmental Language Disorder, Stephanie Durrleman, Morgane Burnel, Jill De Villiers, Evelyne Thommen, Rachel Yan, Hélène Delage

Psychology: Faculty Publications

Training on complements in English, German, and Mandarin has been reported to trigger improvements on both complements and Theory of Mind (ToM), with typically developing (TD) pre-schoolers on the verge of developing these skills (Hale and Tager-Flusberg, 2003; Lohmann and Tomasello, 2003; Shuliang et al., 2014). In the current study, we build on the idea that increasing mastery of complementation holds the promise of enhancing ToM, and seek (i) to replicate the positive effects observed in previous work for this effect in French-speaking TD children, and (ii) to pilot extending this to clinical children, more specifically those with Autism Spectrum …

Trends In Prices Of Insulin Marketed In The Us, Hana Althobaiti

Pharmaceutical Sciences (MS) Theses

INTRODUCTION: Diabetes mellitus is one of the most prevalent and costly chronic diseases in the United States (US). The healthcare and drug cost of diabetes has risen steadily and the increase in patients’ out-of-pocket drug expenditures are associated with a reduction in treatment adherence. The objectives of this study were to assess trends in insulin products prices in the period January 1983-July 2019, and to compare the price, acquisition costs and reimbursement amount of insulins available in the US.

DATA AND METHODS: Data of insulin products marketed in the US during the period January 1983-July 2019 was derived from the …

Some Preliminary Observations With The Native Health Database, Jonathan Pringle

Native Health Database project records

Presentation about the NHD for the ATALM annual meeting.

We Need To Change The Language We Use To Describe Individuals With Substance Use Issues, Austin Mcneill Brown

Population Health Research Brief Series

People with substance use disorders (SUDs) are highly stigmatized worldwide. This research brief describes the results from several studies on unconscious bias and negative language used to describe individuals with SUDs.

Reconstructive Trends And Complications Following Parotidectomy: Incidence And Predictors In 11,057 Cases., Cory D Bovenzi, Peter Ciolek, Meghan Crippen, Joseph M Curry, Howard Krein, Ryan Heffelfinger

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

BACKGROUND: Parotidectomy is a common treatment option for parotid neoplasms and the complications associated with this procedure can cause significant morbidity. Reconstruction following parotidectomy is utilized to address contour deformity and facial nerve paralysis. This study aims to demonstrate national trends in parotidectomy patients and identify factors associated with adverse postoperative outcomes. This study includes the largest patient database to date in determining epidemiologic trends, reconstructive trends, and prevalence of adverse events following parotidectomy.

METHODS: A retrospective review was performed for parotidectomies included in the ACS-NSQIP database between January 2012 and December 2017. CPT codes were used to identify the …

Chronic Obstructive Pulmonary Disease (Copd) And The Nutrition Care Process, Emily Anderson

Nutrition & Dietetics Student Publications

This paper displays the role that Registered Dietitians can play in the care of patients with COPD and it’s related side effects. A registered dietitian nutritionist’s (RDNs) job is to ensure adequate care through thorough assessment, diagnosis, treatment and evaluation, otherwise known as the Nutrition Care Process (ADIME-NCP). Through the story of my uncle and his journey with COPD you are able to understand the struggles this chronic disease can have and how RDN’s play a role in their care.

Identification Of Novel Adenylyl Cyclase 5 (Ac5) Signaling Networks In D1 And D2 Medium Spiny Neurons Using Bimolecular Fluorescence Complementation Screening, Trevor B. Doyle, Brian S. Muntean, Karin F. Ejendal, Michael P. Hayes, Monica Soto-Velasquez, Kirill A. Martemyanov, Carmen W. Dessauer, Chang-Deng Hu, Val J. Watts

Purdue University Libraries Open Access Publishing Fund

Adenylyl cyclase type 5 (AC5), as the principal isoform expressed in striatal medium spiny neurons (MSNs), is essential for the integration of both stimulatory and inhibitory midbrain signals that initiate from dopaminergic G protein-coupled receptor (GPCR) activation. The spatial and temporal control of cAMP signaling is dependent upon the composition of local regulatory protein networks. However, there is little understanding of how adenylyl cyclase protein interaction networks adapt to the multifarious pressures of integrating acute versus chronic and inhibitory vs. stimulatory receptor signaling in striatal MSNs. Here, we presented the development of a novel bimolecular fluorescence complementation (BiFC)-based protein-protein interaction …

Role Of Probiotics In Non-Alcoholic Fatty Liver Disease: Does Gut Microbiota Matter?, Chencheng Xie, Dina Halegoua-De Marzio

Division of Gastroenterology and Hepatology Faculty Papers

Non-alcoholic fatty liver disease (NAFLD) is the hepatic consequence of metabolic syndrome, which often also includes obesity, diabetes, and dyslipidemia. The connection between gut microbiota (GM) and NAFLD has attracted significant attention in recent years. Data has shown that GM affects hepatic lipid metabolism and influences the balance between pro/anti-inflammatory effectors in the liver. Although studies reveal the association between GM dysbiosis and NAFLD, decoding the mechanisms of gut dysbiosis resulting in NAFLD remains challenging. The potential pathophysiology that links GM dysbiosis to NAFLD can be summarized as: (1) disrupting the balance between energy harvest and expenditure, (2) promoting hepatic …

A Prospective Clinical Study On Implant Impression Accuracy, Motaz Osman, Hassan Ziada, Ahmed Suliman, Neamat Hassan Abubakr

Dental Medicine Faculty Research

Background An accurate impression is crucial to the long-term success of dental implants. This investigation evaluated the accuracy of the open and closed implant impression techniques in partially edentulous patients who received two adjacent implants. Material and methods Forty patients received Osstem Implants (Osstem Implant System, Seoul, Korea). Two impressions were made for each patient, one using an open tray and a second with a closed tray technique. The horizontal distances between two impression copings were measured and compared to similar measurements on the master casts. Also, under a stereomicroscope (AmScop14370, Myford Road, #150, Irvine, CA 92606 USA) at a …

Sirtuin 3 Deficiency Does Not Impede Digit Regeneration In Mice, Emily Busse, Jennifer Simkin, Luis Marrero, Kennon Stewart, Regina Brunauer, Ken Muneoka, Anyonya Guntur, Michelle Lacey, Mimi Sammarco

School of Medicine Faculty Publications

The mitochondrial deacetylase sirtuin 3 (SIRT3) is thought to be one of the main contributors to metabolic flexibility-promoting mitochondrial energy production and maintaining homeostasis. In bone, metabolic profiles are tightly regulated and the loss of SIRT3 has deleterious effects on bone volume in vivo and on osteoblast differentiation in vitro. Despite the prominent role of this protein in bone stem cell proliferation, metabolic activity, and differentiation, the importance of SIRT3 for regeneration after bone injury has never been reported. We show here, using the mouse digit amputation model, that SIRT3 deficiency has no impact on the regenerative capacity and architecture …

Using Smartwatches For Fitness And Health Monitoring: The Utaut2 Combined With Threat Appraisal As Moderators, Phaik Khee Beh, Yuvaraj Ganesan, Mohammad Iranmanesh, Behzad Foroughi

Research outputs 2014 to 2021

Recent advancements in smartwatch technology have led to several applications in continuous fitness and health monitoring. Considering the benefits of smartwatches, their low level of usage for fitness and health monitoring purposes, and the limited understanding of determinants of their usage, this study advances the body of knowledge by developing an innovative and comprehensive research model that integrates the extended unified theory of acceptance and use of technology (UTAUT2) with perceived vulnerability and perceived severity as moderators. The model was tested using partial least squares (PLS), in a quantitative study with data from 271 respondents from Malaysia. The results showed …

Defining The Layers Of A Sensory Cilium With Storm And Cryoelectron Nanoscopy, Michael A Robichaux, Valencia L Potter, Zhixian Zhang, Feng He, Jun Liu, Michael F Schmid, Theodore G Wensel

Faculty, Staff and Students Publications

Primary cilia carry out numerous signaling and sensory functions, and defects in them, "ciliopathies," cause a range of symptoms, including blindness. Understanding of their nanometer-scale ciliary substructures and their disruptions in ciliopathies has been hindered by limitations of conventional microscopic techniques. We have combined cryoelectron tomography, enhanced by subtomogram averaging, with superresolution stochastic optical reconstruction microscopy (STORM) to define subdomains within the light-sensing rod sensory cilium of mouse retinas and reveal previously unknown substructures formed by resident proteins. Domains are demarcated by structural features such as the axoneme and its connections to the ciliary membrane, and are correlated with molecular …

The Sexual Values And Behaviors Discrepancy Model, Zachary D. Bloom, Ashley J. Blount, Dalena L. Dillman Taylor, Galina Lipkin

Journal of Counseling Sexology & Sexual Wellness: Research, Practice, and Education

Founded in theory and empirical research, we developed the Sexual Values and Behaviors Discrepancy Model (SVBDM) as reflective model for counselors to follow in order to assist their clients in safely reducing discrepancies between their ideal and practiced sexual beliefs, values, and behaviors. The SVBDM is a wellness-informed and sex-positive approach to working with clients and is comprised of three steps: Identification and Operationalization of Potential Sexual Issues, Counselor’s Self-Assessment, and Reducing Discrepancies and Maintaining Safety. We note practical implications and potential limitations of this model as well as recommendations for future research.

Summary Of The International Patient Safety Conference, June 28-29, 2019, Kathmandu, Nepal, Deepak C. Bajracharya, Kshitij Karki, Chhiring Yangjen Lama, Rajesh Dhoj Joshi, Shankar Man Rai, Sudhakar Jayaram, Amit Tomer, John Zervos, Mohammad Imran Khan, Arjun Sapkota, Madan Kumar Upadhyaya, Paul E. Kilgore

Department of Pharmacy Practice

Globally, medical errors are associated with an estimated $42 billion in costs to healthcare systems. A variety of errors in the delivery of healthcare have been identified by the World Health Organization and it is believed that about 50% of all errors are preventable. Initiatives to improve patient safety are now garnering increased attention across a range of countries in all regions of the world. From June 28--29, 2019, the first International Patient Safety Conference (IPSC) was held in Kathmandu, Nepal and attended by over 200 healthcare professionals as well as hospital, government, and non-governmental organization leaders. During the conference, …

Ada News - 11/18/2019, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

What's Happening: November 18, 2019, Maine Medical Center

What's Happening

No abstract provided.

Neuron Specific Gene 2 (Nsg2): A Novel Regulator Of Excitatory Neurotransmission Via Ampa Receptor Trafficking At A Subset Of Glutamatergic Synapses, Praveen Chander

Biomedical Sciences ETDs

Members of the Neuron-Specific Gene family (NSG1-3) play critical roles in excitatory synaptic transmission via regulation of AMPA receptor surface expression within the post-synaptic density (PSD). While NSG1 and NSG3 regulate AMPAR recycling and endocytosis, respectively, the function of NSG2 has remained elusive. Here we undertook a series of studies to assess the role of NSG2 in excitatory synaptic transmission. We found that a portion of NSG2 punctae localized with HOMER1 and surface AMPARs at excitatory synapses and that NSG2 AMPAR subunits in mouse brain. Knockout of NSG2 selectively impaired the frequency of AMPA mEPSCs, while overexpression caused a significant …

Concomitant Presentation With Cardioembolic Ischemic Stroke And Non St Elevation Myocardial Infarction In A Patient With New Onset Atrial Fibrillation, Amogh M. Joshi Do, Emilee E. Kurtz Do, Kourtney Erickson Do, Margaret R. Kluck Do, Benjamin Sanchez Md

Department of Medicine

Introduction: Although Atrial Fibrillation (AF) is a common cause of ischemic stroke, it rarely causes acute coronary syndromes (ACS). Cardioembolic events from AF cause considerable morbidity and mortality. Concomitant ischemic stroke and ACS remains an exceedingly rare event. We describe the case of a patient presenting with cardioembolic ischemic stroke and acute coronary syndrome.

Case Presentation: An 83 year old male with a prior history of heart failure with preserved ejection fraction, permanent pacemaker for complete heart block, and chronic kidney disease on hemodialysis presented with acute left sided facial and extremity weakness, gait ataxia and profound dysarthria. Physical examination …

Medical School Watercooler Newsletter - November 17, 2019, Lindsey Lyle

Watercooler Newsletter

This is the November 17, 2019 edition of the Frederick P. Whiddon College of Medicine's Newsletter - Watercooler.

Contents Include:

Orthopaedic surgery grand rounds to focus on SLAP tears, shoulder biomechanics

Cardiology fellow to present on heart failure at grand rounds

Fonseca to discuss management of pancreatic cancer at surgery grand rounds

Neurosurgery faculty member named to national 20 under 40 list

Management Of Traumatic Subarachnoid Hemorrhage By The Trauma Service: Is Repeat Ct Scanning And Routine Neurosurgical Consultation Necessary?, Stephen W. Cooper, Kimberly B. Bethea, Trevor J. Skrobut, Rod G. Gerardo, Juan Torres-Reveron, Akpofure Peter Ekeh

Department of Surgery Faculty Publications

Subarachnoid hemorrhage (SAH) results frequently from traumatic brain injury (TBI). The standard management for these patients includes brief admission by the acute care surgery (trauma) service with neurological checks, neurosurgical consultation and repeat head CT within 24 hours to identify any progression or resolution. Recent studies have questioned the need for repeat CT imaging and specialty consultation in mild TBI. We reviewed patients with mild TBI specifically with isolated SAH to determine progression of the pathology and need for neurosurgical involvement. All patients with SAH secondary to mild TBI (Glasgow Coma Score (GCS) of 13-15) who presented over a 5-year …

Volume Changes After Traumatic Spinal Cord Injury In Animal Studies - A Systematic Review, Mahdi Sharif-Alhoseini, Fariba Vahedi, Mahmoud Omidbeigi, Marzieh Sharifi, Zahra Hassannejad, Shayan Abdollah Zadegan, Motahareh Rezvan, Mona Mokhatab, Kiavash Sajadi, Aida Shakouri-Motlagh, Farhad Shokraneh, Alexander R. Vaccaro, Vafa Rahimi Movaghar

Department of Orthopaedic Surgery Faculty Papers

There are limited data on the lesion volume changes following spinal cord injury (SCI). In this study, a meta-analysis was performed to evaluate the volume size changes of the injured spinal cord over time among animal studies in traumatic SCI. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we conducted a comprehensive electronic search of English literature of PubMed and EMBASE databases from 1946 to 2015 concerning the time-dependent changes in the volume of the spinal cord following mechanical traumatic SCI. A hand-search was also performed for non-interventional, non-molecular, and non-review studies. Quality appraisal, data extraction, …

Outcomes In Patients With Gunshot Wounds To The Brain, Leigh Anna Robinson, Lauren M. Turco, Bryce Robinson, Joshua G. Corsa, Michael Mount, Amy V. Hamrick, John Berne, Dalier R. Mederos, Allison G. Mcnickle, Paul J. Chestovich, Jason Weinberger, Areg Grigorian, Jeffry Nahmias, Jane K. Lee, Kevin L. Chow, Erik J. Olson, Jose L. Pascual, Rachele Solomon, Danielle A. Pigneri, Husayn A. Ladhani, Joanne Fraifogl, Terry Curry, Todd W. Costantini, Manasnun Kongwibulwut, Haytham Kaafarani, Janika San Roman, Craig Schreiber, Anna Goldenberg-Sandau, Parker Hu, Patrick Bosarge, Rindi Uhlich

School of Medicine Faculty Research

Introduction: Gunshot wounds to the brain (GSWB) confer high lethality and uncertain recovery. It is unclear which patients benefit from aggressive resuscitation, and furthermore whether patients with GSWB undergoing cardiopulmonary resuscitation (CPR) have potential for survival or organ donation. Therefore, we sought to determine the rates of survival and organ donation, as well as identify factors associated with both outcomes in patients with GSWB undergoing CPR. Methods: We performed a retrospective, multicenter study at 25 US trauma centers including dates between June 1, 2011 and December 31, 2017. Patients were included if they suffered isolated GSWB and required CPR at …

Outcomes In Patients With Gunshot Wounds To The Brain., Leigh Anna Robinson, Lauren M Turco, Bryce Robinson, Joshua G Corsa, Michael Mount, Amy V Hamrick, John Berne, Dalier R Mederos, Allison G Mcnickle, Paul J Chestovich, Jason Weinberger, Areg Grigorian, Jeffry Nahmias, Jane K Lee, Kevin L Chow, Erik J Olson, Jose L Pascual, Rachele Solomon, Danielle A Pigneri, Husayn A Ladhani, Joanne Fraifogl, Jeffrey Claridge, Terry Curry, Todd W Costantini, Manasnun Kongwibulwut, Haytham Kaafarani, Janika San Roman, Craig Schreiber, Anna Goldenberg-Sandau, Parker Hu, Patrick Bosarge, Rindi Uhlich, Nicole Lunardi, Farooq Usmani, Joseph Victor Sakran, Jessica M Babcock, Juan Carlos Quispe, Lawrence Lottenberg, Donna Cabral, Grace Chang, Jhoanna Gulmatico, Jonathan J Parks, Rishi Rattan, Jennifer Massetti, Onaona Gurney, Brandon Bruns, Alison A Smith, Chrissy Guidry, Matthew E Kutcher, Melissa S Logan, Michelle Y Kincaid, Chance Spalding, Matthew Noorbaksh, Frances H Philp, Benjamin Cragun, Robert D Winfield

Trauma and Acute Care Articles

INTRODUCTION: Gunshot wounds to the brain (GSWB) confer high lethality and uncertain recovery. It is unclear which patients benefit from aggressive resuscitation, and furthermore whether patients with GSWB undergoing cardiopulmonary resuscitation (CPR) have potential for survival or organ donation. Therefore, we sought to determine the rates of survival and organ donation, as well as identify factors associated with both outcomes in patients with GSWB undergoing CPR.

METHODS: We performed a retrospective, multicenter study at 25 US trauma centers including dates between June 1, 2011 and December 31, 2017. Patients were included if they suffered isolated GSWB and required CPR at …

Treatment And Outcome Improvement With Implementation Of A System-Wide Comprehensive Plan Of Care For Management Of Isolated Hip Fractures, C. Michael Lecroy, Adam Kaufman, Christina Mcquiston, Harold Michael Frisch, Martha Hoskyns, Sean Snyder, Terrie Smith, Jaclyn Gosnell, Michael J. Schurr, William Shillinglaw

Orthopedic Surgery

No abstract provided.

‘Navigating’ The Huntington’S Disease Community Towards Crucial Clinical Trials, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Creutzfeldt Jakob Disease: Progressive Neurological Decline, Christine Fayad Md, Scott J. Anderson, H. Alex Akhondi Md

Internal Medicine

No abstract provided.

Utilizing The Community-Based Research Approach To Examine Mental Health And Support Services Issues Related To Hiv-Associated Neurocognitive Disorder, Renato M. Liboro

Psychology Faculty Research

Human immunodeficiency virus (HIV)-associated neurocognitive disorder is an emergent public health problem known to HIV researchers and scientists, but unfortunately, is a concern that still needs to be better recognized by people living with HIV and HIV service providers. Research studies have reported that between 30 to 50% of people living with HIV who have access to combination antiretroviral therapy are and will be affected by this disorder. This raises the need to find more appropriate research approaches for examining issues that will significantly impact people living with HIV experiencing or at risk of developing neurocognitive impairments. People living with …

Healthy Older Adults’ Motivation And Knowledge Related To Food And Meals, Kai Victor Hansen

The Qualitative Report

The population over 60 years old is growing rapidly in Norway and in many other countries, and researchers often focus on elderly people and various diseases. This article examines the healthy elderly who are active in their daily lives to understand their motivation and knowledge about food and meals. The method used was CurroCus® group interviews, or fast focus groups. Nine CurroCus® groups were conducted, lasting for 37 to 56 minutes (average = 45 minutes). Altogether, 76 persons participated, ranging in age from 60 to 87 years; participants were predominantly female (>80%). The article discusses two areas: motivation and …

How Unstructured Data From The Data Warehouse Can Be Used With Machine Learning And Visualization To Develop Novel Medical Technologies, Alfred A. Cecchetti

Faculty Research Day

Machine Learning (ML) can accurately classify and accurately predict disease as well as other medical events.

Device Programming, especially smartphone applications, can provide new ways to acquire, transport, store, process, and secure personalized patient data to deliver meaningful results.