Medicine and Health Sciences Commons^™

Validated And Culturally Specific Screening Tools And Early Response Programs For The Detection And Prevention Of Eating Disorders Among First Nations Peoples In Australia: A Scoping Review, Mark John Castro, Zyana Gall, Alana Gall, Hilary Smith, Kanita Kunaratnam

Research outputs 2022 to 2026

Background: Eating disorders (EDs) are complex mental health conditions that can have severe health consequences, exacerbating the overall disease burden and causing significant economic impacts on healthcare systems. Globally, cultural and societal factors influence the presentation and management of these disorders, necessitating culturally specific approaches to screening and prevention. Among First Nations peoples in Australia, the intersection of historical, cultural, and social factors offers both context and strength in addressing EDs, while also presenting distinct challenges in identification and prevention. Objective: This scoping review seeks to map and evaluate existing research on culturally specific and validated screening tools and early …

Co-Design Of A Personalised Physical Activity Intervention For Stroke Survivors, Natalie A. Fini, Emily R. Ramage, Julie R. Bernhardt, Erin M. Bicknell, Chris C.M. Tzefronis, Paul M. Fink, Erin Godecke, Jill L. Francis, Rebecca Wood, Nicole Li, Brandon Lin, Coralie English, Catherine M. Said

Research outputs 2022 to 2026

Introduction/ aims: Incorporating the perspectives of knowledge-users such as stroke survivors into intervention development processes can enhance their relevance and feasibility. The aims of this study were: i) to use co-design to determine “active ingredients” and develop a personalised physical activity intervention for stroke survivors, and ii) to evaluate the co-design process. Methods: A four-stage integrated knowledge translation approach (involving planning and workshops) was applied to co-design a post-stroke physical activity intervention. Knowledge-user participants (stroke survivors (n = 10), carers (n = 3) and clinicians (n = 12)) were recruited. Knowledge-user participants (n = 25) and the research team (n …

Cognitive Frailty And Cardiometabolic Risk In Middle-Aged And Older Adults: Evidence From The Uk And China, Haiyang Yan, Jingjing Lang, Chengfeng Li, Samaneh Eftekhariranjbar, Guoyan Jiang, Jing Lei, Lixin Sun, Carlos J. Toro-Huamanchumo, Zhongyang Guan

Research outputs 2022 to 2026

Background: Cognitive frailty, a novel construct integrating cognitive and physical deficits, is increasingly recognized in aging research. Aims: This study aimed to examine the associations between cognitive frailty and cardiometabolic risk in two nationally representative cohorts from China and the United Kingdom. Methods: We analyzed data from 7,628 participants in the China Health and Retirement Longitudinal Study (CHARLS) and 4,703 participants from the English Longitudinal Study of Ageing (ELSA), all aged ≥ 50 years. Frailty was assessed using the frailty index (FI) in the main analysis. Cox proportional hazards models were applied to estimate hazard ratios (HRs) for incident cardiometabolic …

Exploring Convergence And Divergence In Seemingly Contrasting Perspectives On Training Perceptual-Cognitive Abilities For Sports Performance Through Moderated Dialogue, Jordan Cassidy, Daniel Kadlec, Job Fransen

Research outputs 2022 to 2026

Current Opinion article considers the diverging perspectives of two academics on the trainability and role of perceptual-cognitive abilities in sports performance, specifically applied to agility and sidestepping. This work uses a moderated dialogue approach between these two authors, each representing differing viewpoints: one advocating for the role of perceptual-motor skills through representative learning environments and another emphasising physical resilience. The article explores how fostering scientific discourse through moderated questions posed by a third party can be used to identify convergences and divergences in these perspectives. Both perspectives agree on the complexity of agility, the value of coupling perceptual skills with …

High-Dose Beta-Alanine Supplementation For Two Weeks Did Not Enhance Intermittent Endurance Or Sprint Performance In Trained Futsal Players, Hossein Miraftabi, Erfan Berjisian, Marzieh Nouri Dizicheh, Alireza Naderi, Masoud Bodaghi, Majid S. Koozehchian, Fatemeh Shabkhiz, Alvaro Lopez-Samanes

Research outputs 2022 to 2026

Background: This study aimed to investigate the effects of a high-dose beta-alanine (BA) supplementation on physical performance, blood lactate concentration, and ratings of perceived exertion (RPE) in trained futsal players. Methods: Sixteen trained futsal players participated in a randomized, parallel, double-blind experiment, completing a two-week supplementation period with either 12 g/day of BA (n = 8; age: 19 ± 2 years; height: 1.78 ± 0.03 m; body mass: 68.5 ± 5.4 kg) or a placebo (PLA) (n = 8; age: 18 ± 1 years; height: 1.74 ± 0.08 m; body mass: 65.6 ± 6.4 kg). Athletes completed the futsal intermittent …

A Qualitative Study Of Treatment Adherence From The Perspective Of Nurses And Patients Following Acute Coronary Syndrome, Amineh Rashidi, Lisa Whitehead, Lisa Newson, Andrea Connolly, Suzanne Robinson, Prachi Kaistha, Mark Makokha, Rebecca Larsen, Rosemary Saunders

Research outputs 2022 to 2026

Aim: To gain an understanding of potential aspects influencing treatment adherence for patients with acute coronary syndrome. Design: A qualitative deductive approach. Methods: Patient and nurse participants were recruited from a single hospital in Australia, who participated in a semi-structured interview. Data were analysed using a deductive thematic analysis. Results: Fifteen patients with acute coronary syndrome and 13 registered nurses participated in the study. Potential aspects influencing treatment adherence included perceived risk, perceived benefits, perceived barriers, self-efficacy, and cues to action. Conclusion: This study provides insights into the limited evidence into understanding the aspects that influence treatment adherence for acute …

Factors Influencing The Provision Of Human Milk Feeding Support For Preterm Infants In Neonatal Intensive Care Units In China: A Qualitative Study Of Neonatal Nurses’ Perspectives, Wenjie Guo, Haiyan Zhang, Li Wang, Fang Huang, Dongmei Ma, Maggie Zgambo, Sanmei Chen, Yan Wu, Yanmei Bu, Yoko Shimpuku

Research outputs 2022 to 2026

Background: Human milk feeding is crucial for the survival and development of preterm infants, yet their human milk feeding rates at Neonatal Intensive Care Units (NICUs) discharge remain lower than those of healthy newborns. Effective support is essential for improving breast milk feeding outcomes, but remains challenging for NICU nurses. Therefore, this study aimed to examine factors that influence NICU nurses in providing human milk feeding support, including the challenges they face and their needs. Methods: This study employed a qualitative descriptive design. Using maximum variation and purposive sampling, 19 nurses in the NICU were recruited. Between August and September …

Longitudinal Associations Between Maternal And Child Screen Use At 1 Year Of Age And Child Behavior And Development At 3 Years Of Age, Stephanie Sim, Juliana Zabatiero, Natasha Bear, Amber Beynon, George Thomas, Ravisha Srinivasjois, Brad Jongeling, Desiree Silva, Leon Straker

Research outputs 2022 to 2026

Background: Young children are increasingly exposed to evolving screen technology. International guidelines recommend no screen use for children under the age of 2 years, due to the potential for detrimental effects on behaviour and development. However, evidence for these guidelines is limited by inadequate consideration of device-specific effects (TV and mobile phone/tablet computer), maternal screen use, confounders such as maternal mental health and importance of effect sizes. Our aim was to investigate longitudinal associations of device-specific maternal and child technology use and covariates (including maternal mental health) with behavioural and developmental outcomes, to guide adults on screen use behaviours by …

Midwife-Led Birth Debrief: A Concept Analysis, Kate Buchanan, Elliesha O'Reilly, Georgia Wilcox, Sara Bayes, Lauren Kearney, Linda Sweet, Hazel Keedle

Research outputs 2022 to 2026

Background: Psychological birth trauma (PBT) affects approximately 19 % of postnatal women, making its prevention a global priority. Midwives are responsible for providing psychosocial care during the postnatal period to foster the mother-infant relationship, provide education and screening and support positive transitions to parenting. However, the specific attributes of a birth debrief and the role of the midwife in a supporting a woman to review their birth experience is less well documented in regulatory frameworks or scientific literature. This has created significant ambiguity in both clinical practice among health professionals and in research contexts. The lack of a clear understanding …

Pact Is Requisite For Prostate Cancer Cell Proliferation, Dianne J. Beveridge, Andrew J. Woo, Kirsty L. Richardson, Rikki A.M. Brown, Lisa M. Stuart, Manjot Singh, Andrew D. Redfern, Peter J. Leedman

Research outputs 2022 to 2026

PACT (encoded by the PRKRA gene) is a double-stranded RNA binding protein with defined antiviral defense and cytoplasmic RNA-induced silencing actions in mammals. We previously described a further role for PACT as a modulator of nuclear receptor (NR)-regulated gene expression. Here, we investigated the role of PACT in prostate cancer (PCa) using a loss-of-function approach. Depletion of PACT in multiple PCa cell lines resulted in a reduction in cell proliferation, but viability was maintained. RNA-sequencing analysis of LNCaP PCa cells ± PACT revealed a depletion of biological processes involved in cell cycle, mitochondrial function, and NR-response pathways in the PACT …

Periodizing Exercise Medicine Prescription For Patients With Cancer: A Narrative Opinion, Francesco Bettariga, Robert U. Newton, Chris Bishop, Luca Maestroni, Anita Borsati, Alice Avancini, Sara Pilotto, Dennis R. Taaffe, Daniel A. Galvão, G. Gregory Haff

Research outputs 2022 to 2026

Exercise has emerged as an effective therapeutic strategy in cancer management. Long-term supervised exercise programs, including resistance training and aerobic training, can improve body composition and physical fitness, modulate circulating factors (e.g., hormones, cytokines), enhance treatment tolerance, and reduce side effects, potentially influencing cancer progression and reducing mortality risk. Despite advancements in exercise oncology, opportunities remain to refine exercise prescription through the integration of advanced methodologies such as periodization and autoregulatory programming strategies. Periodization, a systematic approach to organizing training over time, has demonstrated benefits in general fitness and clinical populations but is underexplored in cancer care. Emerging evidence suggests …

Rac1 In Gastric Cancer: A Molecular Driver Of Invasion, Emt, And Therapeutic Resistance, Jianwen Li, Yahong Zhu, Ruifeng Duan, Yueli Tian, Xingang Li, Ying Song

Research outputs 2022 to 2026

Gastric cancer (GC) ranks as the fifth most common cancer worldwide and is the third main cause of cancer-related mortality, posing a substantial burden to global public health. Research suggests that targeted therapy and immunotherapy may become more effective treatment options for advanced, unresectable, or metastatic gastric cancer. Ras-related C3 botulinum toxin substrate 1 (Rac1), a small GTP-binding protein within the Rac subfamily of the Rho GTPase family, is a critical molecule that promotes cancer cell invasion and metastasis by regulating signal transmission and promoting cell polarity. It has emerged as a key driver of tumor development and metastasis in …

Relationships Of Upper Respiratory Tract Infections And Holistic Diets And Lifestyles In Northeast China, Hongmei Wang, Khui Hung Lee, Shaoxiao Qin, Kan Yu, Shaoying Hou, Kaihong Tang, Jiabao Liu, Yingyu Jin, Zhuo Shang, Deyu Dai

Research outputs 2022 to 2026

Background: Upper respiratory tract infections (URTIs) are prevalent public health issues worldwide. Their prevention is challenging, and they pose a significant economic burden due to their susceptibility to secondary infections and lack of effective treatments. This study investigates the relationship between URTIs and the holistic diets and lifestyles of residents in Northeast China. Methods: A cross-sectional study was conducted using data from 4058 participants aged 12 to 70 who participated in the Internet-based dietary questionnaire for Chinese (IDQC), collected between 2012 and 2019. Statistical analyses were performed with SPSS 20.0 software, employing chi-square tests for categorical data and Kruskal-Wallis tests …

The Use Of Force Plate Technology To Measure Force Production Characteristics In Military Personnel: A Scoping Review Of Methodological Reporting Practices, Peter Ladlow, Kieran M. Lunt, Paul Comfort, Oliver O’Sullivan, Francisco J. Robles-Palazón, Nicholas J. Ripley, John J. Mcmahon, Natalie Masters, Robyn P. Cassidy, Marina De Vecchis, Vanessa Bell, Alexander N. Bennett, Russell J. Coppack

Research outputs 2022 to 2026

Background: Force plates have become one of the most frequently used assessment tools in the field of strength and conditioning research and applied practice. Their use for measuring force production characteristics among military personnel is growing. The aim of this scoping review is to: (1) Describe the current evidence base underpinning the use of force plates to assess maximal and rapid lower-limb force production in military in three priority areas; occupational task performance, injury risk profiling, and rehabilitation, (2) Identify potential trends and/or differences by participants’ sex, job role, and/or level of performance in tests, methodologies, and metrics selected, and …

Trends And Determinants Of Early Neonatal Mortality In Ethiopia: Evidence From The Ethiopian Demographic And Health Survey Data, Tsion Mulat Tebeje, Beminate Lemma Seifu, Yordanos Sisay Asgedom, Kusse Urmale Mare, Zufan Alamrie Asmare, Hiwot Altaye Asebe, Abdu Hailu Shibeshi, Afework Alemu Lombebo, Kebede Gemeda Sabo, Bezawit Melak Fente, Bizunesh Fantahun Kase

Research outputs 2022 to 2026

Background: Early neonatal mortality (ENM) accounts for three-fourths of all neonatal deaths and one-third of overall child mortality. While previous studies have primarily focused on neonatal and under-five mortality, ENM has received comparatively less attention. This study aims to address this gap by analyzing trends and identifying factors associated with ENM in Ethiopia. Methods: Data from the Ethiopian Demographic and Health Survey (EDHS) conducted between 2005 and 2016 were analyzed, comprising a total weighted sample of 22,310 participants. To account for the hierarchical structure of the EDHS data, a mixed-effects binary logistic regression model was applied to identify associated factors. …

Triggering Sarcomerogenesis: Examining Key Stimuli And The Role Attributed To Eccentric Training—Historical, Systematic, And Meta-Analytic Review, Anthony J. Blazevich, Walter Herzog, João Pedro Nunes

Research outputs 2022 to 2026

Background: Serial sarcomere number (SSN) critically influences muscle function and is hypothesized to protect against injury. While most evidence for SSN addition comes from non-human animal studies, eccentric exercise is often proposed as a key stimulus due to its association with increased fascicle length in humans. However, the most efficient exercise stimuli and the effectiveness of eccentric training in increasing SSN remain unclear. The objective of this study was to provide a detailed historical overview of research exploring the mechanical factors regulating muscle/fiber length and its relationship with function, and to explore more recent evidence that eccentric muscle contractions might …

What Are The Optimal Transcranial Direct Current Stimulation Parameters And Design Elements To Modulate Corticospinal Excitability? A Systematic Review And Longitudinal Meta-Analysis, Liam C. Tapsell, Matheus D. Pinto, Ann Maree Vallence, Casey Whife, Maria Luciana Perez Armendariz, Shaswat Senger, Jack Andringa-Bate, Dana Hince, Myles C. Murphy

Research outputs 2022 to 2026

Background: Corticospinal excitability, measured by motor-evoked potentials (MEPs), is often impaired in neurological and musculoskeletal conditions. Transcranial direct current stimulation (tDCS) can modulate cortical excitability and improve clinical outcomes, yet inconsistencies in parameter settings complicate identification of optimal protocols. Objective: Our primary objective was to examine the effects of: (i) stimulation polarity, (ii) duration, (iii) intensity, (iv) frequency, (v) electrode montage, and (vi) electrode design (size/shape) on MEP size. Methods: Nine databases were searched from inception to 24th November 2023. We identified 84 individual cohorts (1,709 participants) and assessed time-dependent effects of each parameter on M1 MEP-to-baseline ratio in healthy …

Hypophosphatemia Across The Lifespan, Madhuni Herath, Richard Prince, Craig F. Munns, Albert Kim

Research outputs 2022 to 2026

No abstract provided.

Imbalances In Circulating Monocyte And High-Density Lipoprotein Cholesterol Exacerbates The Residual Risk Of Incident Myocardial Infarction Beyond Ldl-C: A Real-Life, Prospective Cohort Study, Dan Wu, Yulong Lan, Xiong Ding, Lois Balmer, Xingang Li, Wei Wang, Shouling Wu, Youren Chen

Research outputs 2022 to 2026

Background: A sustained oversupply of monocytes and markedly decreased levels of high-density lipoprotein cholesterol (HDL-C) are notable in high-risk groups with residual cardiovascular risk, despite aggressive low-density lipoprotein cholesterol (LDL-C) lowering. This study aimed to explore whether an imbalance in circulating monocyte and HDL-C levels accounts for the residual risk of incident myocardial infarction (MI) within optimal LDL-C levels. Methods: A total of 48,522 participants free of cardiovascular diseases from a real-life, prospective cohort (Kailuan study) were included. The monocyte count, HDL-C level and monocyte-to-HDL-C ratio (MHR), calculated as time-averaged cumulative and baseline values, were used as the exposures. Time-to-event …

Live High-Train Low Induced Changes In Hemoglobin Mass And The Erythropoietin-Erythroferrone-Hepcidin Axis In Female Endurance Athletes, Titta Kuorelahti, Johanna K. Ihalainen, Vesa Linnamo, Claire Badenhorst, Oona Kettunen, Ritva Mikkonen

Research outputs 2022 to 2026

The effects of a 21-day live high-train low (LHTL) on hemoglobin mass (Hbmass) and iron demand including the erythropoietin (EPO)-erythroferrone (ERFE)-hepcidin axis and routine iron markers were investigated. Fifteen female endurance athletes completed either 21-day LHTL in normobaric hypoxia (2500 m, ~18 h·day⁻¹) (INT, n = 8) or lived and trained in normoxia (CON, n = 7). Hbmass and resting blood were collected before and after the intervention. An additional blood sample was collected on Day 6 for INT. 21-day LHTL increased Hbmass 3.8% in INT (p < 0.001). EPO increased 35.6% from Day 0 to Day 6 in INT (p = 0.037) and then decreased 42.4% from Day 6 to Day 21 (p = 0.019). In INT, no changes were detected in ERFE or hepcidin, and from the routine iron markers only serum transferrin receptor increased from Day 0 to Day 21 (13.9%, p = 0.013). In CON, no changes were detected in Hbmass or iron markers. In INT, Hbmass and ferritin were positively associated (Day 0 to Day 6, p = 0.005). Thus, hepcidin and ERFE may not provide additional information regarding iron demand following 6- or 21-day LHTL compared to routine iron markers. The relationship between Hbmass and ferritin indicates that adequate ferritin levels are needed during hypoxia to support hematological adaptations.

Muscle Imaging Assessments In Sarcopenia: A Statement From China National Center For Orthopedics (Nco) And The East Meets West Action Group Of The European Calcified Tissue Society (Ects), Ling Wang, Shuai Lu, Jiahua Feng, Kairui Ma, Fangfang Duan, Renxian Wang, Xiaoguang Cheng, Yajun Liu, Yuuki Imai, Hailing Chen, Claus C. Glüer, Giuseppe Guglielmi, Annegreet G. Vlug, Jianmin Liu, Klaus Engelke, Mei Li, Marc Sim, Salvatore Minisola, Xieyuan Jiang

Research outputs 2022 to 2026

Sarcopenia, characterized by progressive loss of muscle mass, strength, and function, significantly impacts patient outcomes. Accurate assessment of muscle mass is essential for its diagnosis. Currently the agreement on how to use imaging for sarcopenia detection is still debated and how well the muscle imaging assessments correlate with muscle function needs further agreement. Recognizing the critical role of imaging in this process, the China National Center for Orthopedics (NCO) and the East Meets West Action Group of European Calcified Tissue Society (ECTS) convened a working group endorsed by the Board of the ECTS. This paper aims to evaluate the utility …

Non-Pharmacological Supportive Care Interventions During Immunotherapy For People With Cancer: A Systematic Scoping Review And Future Directions, Morgan J. Farley, Brighid R. Scanlon, Megan Crichton, Ashley M. Bigaran, Amy C.M. Barnes, Nicolas H. Hart, Patsy M. Yates, Melissa L. Eastgate, Kim Alexander

Research outputs 2022 to 2026

Purpose: Immunotherapy has transformed cancer treatment and outcomes. Patients receiving immunotherapy often encounter immune-related and treatment-related adverse events, leading to substantial supportive care needs. Currently, no recommendations exist to guide the use of non-pharmacological supportive care interventions for people with cancer undergoing immunotherapy treatments. This review aims to summarise the available evidence regarding non-pharmacological supportive care strategies to inform future clinical management and research directions.

Methods: Six electronic databases (PubMed, CINAHL, EMBASE, PsycInfo, Web of Science and Scopus) were systematically searched for studies on non-pharmacological supportive care interventions for adults undergoing immunotherapy, published from October 2014 to October 2024.

Results: …

Safety Of Bioelectrical Impedance Analysis In Patients With Cardiac Implantable Electronic Devices: A Systematic Review, Leonardo J. Uribe-Cavero, Fabian A. Chavez-Ecos, Kiara Camacho-Caballero, José Carlos Grados-Pintos, Patricia Vera-Maccha, Anthony Siguas-Huasasquiche, Dinesh Sharma, Carlos J. Toro-Huamanchumo

Research outputs 2022 to 2026

Background Bioelectrical impedance analysis (BIA) is widely used to assess body composition. However, its safety in patients with cardiac implantable electronic devices (CIEDs) remains uncertain owing to potential electromagnetic interference (EMI). Objective This study aimed to evaluate potential complications associated with clinical-grade BIA use in patients with CIEDs, based on currently available evidence. Methods We conducted a systematic review of studies published up to December 26, 2024, identified through PubMed, Embase, Scopus, and the Cochrane Library. The primary outcome was the occurrence of adverse events, including EMI, device malfunction, or arrhythmias. Results Of 3668 records, 6 cohort studies (n = …

Sertraline To Reduce Recidivism In Impulsive Violent Offenders (Reinvest): A Randomised Double Blind Clinical Trial, Tony Butler, Emaediong I. Akpanekpo, Lee Knight, Kristy Robledo, David Greenberg, Andrew Ellis, Stephen Allnutt, Kay Wilhelm, Alison Jones, Rodney Scott, Bianca Ton, Luke Grant, Philip Mitchell, Ross Tynan, Jocelyn Jones, Dominic Villa, Duncan Chappell, Carolynn Dixon, Alison Churchill, Val Gebski, Tony Keech, Peter W. Schofield

Research outputs 2022 to 2026

Background: Biological studies suggest serotonin modulation via selective serotonin reuptake inhibitors (SSRIs) might reduce impulsive violence, however, robust evidence in offender populations is limited. We aimed to determine whether sertraline reduces violent reoffending compared with placebo in highly impulsive men with recurrent violent offending.

Methods: We conducted a double-blind, placebo-controlled, randomised clinical trial in community settings in New South Wales, Australia. Eligible participants were men aged 18 years or older with ≥2 prior violent convictions and a Barratt Impulsiveness Scale score ≥70. Following a 4-week single-blind active run-in phase with sertraline, participants were randomly assigned (1:1, minimization stratified by key …

The Effects Of Acute And Chronic Exercise On Lipocalin-2 In Middle-Aged And Older Adults: A Randomized Control Trial, Carlie Bauer, Marc Sim, Cassandra Smith, Rhiannon Healy, Andrew Garnham, Navabeh Zare-Kookandeh, Elizabeth Byrnes, Mary N. Woessner, Joshua R. Lewis, Itamar Levinger

Research outputs 2022 to 2026

Objective Chronically elevated circulating lipocalin-2 (LCN2) levels are implicated in poor energy regulation, increased cardio-metabolic disease risk, and poor physical function. Exercise is known to improve these factors, but whether LCN2 is modifiable by exercise is not clear. We examined the effect of acute and chronic exercise on LCN2 levels and whether this relates to glucose regulation, body composition, and physical function. Design and methods Thirty-three middle-aged and older adults (45–84 years, median body mass index 26.21 kg/m²) completed an acute high-intensity interval exercise session (HIIE). Participants were randomized to 4 weeks of high-intensity interval training (HIIT) or …

What Is Known About Asthma Care And Management For Children And Young People Under 18 Years Of Age In New Zealand. A Scoping Review, J. Blamires, M. Foster, B. Kanengoni-Nyatara

Research outputs 2022 to 2026

Introduction: Asthma is the most common chronic health condition affecting children in Aotearoa New Zealand, with Māori and Pacific children disproportionately burdened by high morbidity and inequitable care. Despite clinical guidelines and growing research, inconsistencies in diagnosis, treatment adherence, and education persist. This scoping review identifies and maps literature on care models, service delivery, education and support strategies, and experiences of children, young people, and their family/whānau in asthma care and management for those under 18 in Aotearoa New Zealand. Methods: This scoping review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses Extension for Scoping …

Rhinovirus C15 Infection Induces Airway Epithelial Cell Remodeling And Robust Inflammatory Responses: Potential Implications For Airway Obstruction In Children, Yiran Li, Shilpi Singh, Hannah L Briggs, Jordan E Kreger, Alex L Sliwicki, Emily L Eberhardt, Shiuhyang Kuo, Jessica A Czapla, J Kelley Bentley, Heidi R Flori, Amjad Horani, Steven L Brody, Marc B Hershenson

2020-Current year OA Pubs

Despite recognition of rhinovirus-C (RV-C) as a cause of severe respiratory exacerbations, little is known about the pathogenesis of RV-C infections. We infected mucociliary-differentiated primary tracheobronchial epithelial cells with RV-C15 or RV-A16. Initial RNASeq data showed that, compared to RV-A16, RV-C15 decreased expression of genes related to ciliary function while increasing expression of genes associated with mucus secretion and inflammation. Using different airway epithelial cell isolates, we confirmed greater reduction in DNAI2 and FOXJ1 (regulates production of motile cilia) and increased FOXA3 (regulates mucin -related gene expression) after RV-C15 infection compared to RV-A16. Similarly, nasal swab samples from children with …

Determining Timeframes To Death For Imminently Dying Patients: A Retrospective Cohort Study, Tricia O’Connor, Wai Man Liu, Juliane Samara, Joanne Lewis, Karen Strickland, Catherine Paterson

Research outputs 2022 to 2026

Background: Clinicians are frequently asked ‘how long’ questions at end-of-life by patients and those important to them, yet predicting timeframes to death remains uncertain, even in the last weeks and days of life. Patients and families wish to know so they can ask questions, plan, make decisions, have time to visit and say their goodbyes, and have holistic care needs met. Consequently, this necessitates a more accurate assessment of empirical data to better inform prognostication and reduce uncertainty around time until death. The aims of this study were to determine the timeframes for palliative care patients (a) between becoming comatose …

Effects Of Short- And Long-Term Exercise Training On Cancer Cells In Vitro: Insights Into The Mechanistic Associations, Francesco Bettariga, Dennis R. Taaffe, Daniel A. Galvão, Robert U. Newton

Research outputs 2022 to 2026

Exercise is a therapeutic approach in cancer treatment, providing several benefits. Moreover, exercise is associated with a reduced risk for developing a range of cancers and for their recurrence, as well as with improving survival, even though the underlying mechanisms remain unclear. Preclinical and clinical evidence shows that the acute effects of a single exercise session can suppress the growth of various cancer cell lines in vitro. This suppression is potentially due to altered concentrations of hormones (e.g., insulin) and cytokines (e.g., tumor necrosis factor alpha and interleukin 6) after exercise. These factors, known to be involved in tumorigenesis, may …

Exercise Medicine As Adjunct Therapy During Radiation For Cancer Of The Prostate To Improve Treatment Efficacy – Protocol For The Eradicate Study: A Phase Ii Randomised Controlled Trial, Oliver Schumacher, Robert U. Newton, Colin Tang, Raphael Chee, Sjoerd B. Vos, Ronny S. Low, David Joseph, Dennis R. Taaffe, Daniel A. Galvão

Research outputs 2022 to 2026

Background: Tumour hypoxia resulting from inadequate perfusion is common in many solid tumours, including prostate cancer, and constitutes a major limiting factor in radiation therapy that contributes to treatment resistance. Emerging research in preclinical animal models indicates that exercise has the potential to enhance the efficacy of cancer treatment by modulating tumour perfusion and reducing hypoxia; however, evidence from randomised controlled trials is currently lacking. The ‘Exercise medicine as adjunct therapy during RADIation for CAncer of the prostaTE’ (ERADICATE) study is designed to investigate the impact of exercise on treatment response, tumour physiology, and adverse effects of treatment in prostate …