Medicine and Health Sciences Commons^™

Central Auditory Processing Is Altered After Traumatic Brain Injury In Tanzanian Adults, Jonathan D. Lichtenstein, Christopher E. Niemczak, Abigail Fellows, Lindsay J. Wood, Shufaa Masoud, Alexis Rooney, Monika Adhikari, Albert Magohe, Jay C. Buckey

Department of Communication Sciences and Disorders Faculty Scholarship and Creative Works

Traumatic brain injury (TBI) damages pathways throughout the brain and is a significant global health concern, particularly in low- and middle-income countries, where the incidence is high and long-term deficits are prevalent. This study explores the utility of central auditory processing (CAP) testing as a marker of previous TBI. Seventy individuals with a history of moderate to severe TBI (msTBI) were matched by age and sex to 46 healthy controls in Dar es Salaam, Tanzania. Participants underwent comprehensive behavioral CAP testing, including tests of speech-in-noise ability, temporal resolution, and dichotic listening. Multivariate logistic regression showed the Triple Digit Test (TDT) …

The Impact Of High-Fidelity Simulation On Graduate Nursing Students’ Knowledge And Confidence In Septic Shock Management, Shaden Mustafa

Seton Hall University Dissertations and Theses (ETDs)

The purpose of this quality improvement (QI) Doctorate of Nursing (DNP) project was to create and evaluate the impact of high-fidelity simulation-based training (SBT) on graduate nursing students’ knowledge and confidence in diagnosing and treating septic shock. Outcomes were measured with pre- and post-simulation tests featuring competency questions and Likert-scale confidence ratings.

Accordingly, the two research questions guiding this project were: (1) How effective is high-fidelity simulation training in improving students’ knowledge and competence in managing septic shock? (2) How effective is high-fidelity simulation training in enhancing students’ confidence when caring for patients with septic shock?

Septic shock was selected …

Challenges And Strategies For Hypertension Control In The Young Generation In Indonesia: A Bibliometric Review, Gina Maratus Solihah, Dwi Prijatmoko, Novia Luthviatin

Preventia: The Indonesian Journal of Public Health

Hypertension among young people in Indonesia has become an increasingly alarming public health problem due to lifestyle changes, low awareness, and limited access to preventive health services. This review aims to analyze the challenges and strategies for controlling hypertension in young populations based on national and international literature, supported by bibliometric analysis. Data were obtained from the Web of Science (WOS) database and analyzed using VOSviewer to map research trends, keyword relationships, and collaboration networks related to hypertension in youth. The 2018 Riskesdas data showed that 34.1% of Indonesian adults aged ≥18 years had hypertension, with major risk factors including …

The Influence Of Health Students' Attitudes On Tobacco Control And Tobacco Education On Family Smoking Cessation, Lies Permana, Riza Hayati Ifroh, Annisa Nurrachmawati

Preventia: The Indonesian Journal of Public Health

Health students are aware of how smoking affects people's health. They are typically well-equipped to help smokers quit and play a significant role in tobacco control. The purpose of this study was to determine the role that students have in encouraging their families to quit smoking both before and after studying in health faculty, as well as the impact that health students' attitudes and tobacco control education have on these inquiries. In March and April of 2024, a cross-sectional survey was conducted using the GHPSS questionnaire, with 123 student in Universitas Mulawarman, grade 2nd public health faculty. The findings showed …

Disaster Risk Reduction In Rural Indonesia: Evaluation Of The Japan Red Cross Program In Pujiharjo Village, Meyralda Dara Adisa, Pujo Widodo, Anwar Kurniadi, Wilopo Wilopo

Preventia: The Indonesian Journal of Public Health

Pujiharjo Village in Malang Regency, Indonesia, is highly vulnerable to natural disasters. In 2021, the Indonesian Red Cross (PMI) partnered with the Japanese Red Cross Society (JRCS) to implement a community-based disaster preparedness program. This study evaluates the program's effectiveness in terms of community participation, institutional support, and alignment with the Sendai Framework for Disaster Risk Reduction 2015–2030. Using a qualitative case study, data were collected through document analysis of Vulnerability and Capacity Assessments (VCA), Community Action Plans (CAP), and local SOPs. Thematic analysis explored disaster risk perception, governance, mitigation investment, and emergency preparedness. The program successfully improved risk awareness, …

Physicians’ Knowledge, Perceptions And Use Of Large Language Models In Clinical Practice: A Cross-Sectional Study At Sultan Qaboos University Hospital, Rahma Al Kindi, Hana Al Sumry, Aisha Al Khamisi, Wijdan Al Rashaidi, Hamza Al Salmi, Adhari Al Zaabi

Sultan Qaboos University Medical Journal

Objectives: This study assessed the knowledge, perceptions and use of ChatGPT and other large language models (LLMs) among physicians at Sultan Qaboos University Hospital (SQUH), Oman. It also explored perceived benefits, barriers and ethical concerns regarding artificial intelligence (AI) integration into clinical practice. Methods: This cross-sectional study was conducted between September and December 2024 using a structured online questionnaire distributed to physicians across different specialties. The survey covered demographics, familiarity with LLMs, applications in medical education, research, clinical care, administrative tasks and ethical considerations. Results: A total of 146 physicians were included (response rate = 48.7%); 65.1% were familiar with …

The Moral Crisis Of Maternal Mortality In The Us, Jensen F. Ware

Honors Theses

This thesis argues that the US crisis of maternal mortality is not an unavoidable tragedy, but a moral and policy failure. I argue that maternal well‑being is one of the most important indicators of a society’s overall health. When mothers receive the care, respect, and support they need, it reflects the strength of healthcare systems, the culture, and our commitment to future generations. The continued loss of mothers from preventable deaths reveals a system that fails many women and their families, especially Black women, low‑income women, and those in rural communities. First, I introduce the issue of maternal mortality in …

Implementation And Evaluation Of A Wellness Program In A First-Year Medical Student Anatomy Course, Gina R. Lepore, Gavin Turner, Benjamin Abramoff, Daniel Depietro, Nicole Robinson

Journal of Wellness

Introduction: Cadaveric dissection is a central component to anatomy education. However, for many students, dissection can be emotionally taxing, highlighting a potential area for increased support. This project evaluated the implementation of a wellness program within a dissection-based anatomy course.

Methods: Throughout a 12-week first-year medical student anatomy course, two teaching assistants (TAs) served as “Wellness TAs” and implemented a structured wellness program that included weekly office hours, supportive emails to students that addressed emotionally challenging coursework, and scheduled “wellness breakfasts/snack breaks.” An anonymous survey was distributed following the course. The survey assessed demographics, perceptions of the anatomical …

Editorial: Advancing Understanding Of Neonatal Bacterial Infections., Susana Chavez-Bueno, Shelley M. Lawrence

Manuscripts, Articles, Book Chapters and Other Papers

No abstract provided.

Dental Care Utilization And Expenditures Among Individuals With Asthma, Shillpa Naaval, Vaibhavi Mone

Health Services and Informatics Research

Objectives To examine dental care utilization and health and dental care expenditures among individuals with asthma.

Methods Data from the 2022 Medical Expenditure Panel Survey (MEPS) (n = 21,405) were used to examine dental care utilization (any dental, preventive dental, and treatment dental visit) among individuals ≥ 1 year with and without asthma, and mean expenditures were summarized.

Results Overall, the asthma diagnosis was 13.2%, 14.7% in working-age adults compared to 9.5% in children. The percentage of treatment dental visits was higher overall (17.0% vs. 14.5%, p <  0.05) among the asthma group compared to the non-asthma group. Among individuals with asthma, those who had preventive dental visits had lower dental expenditures compared to those who had treatment dental visits for all age groups.

Conclusion Individuals with asthma had a higher prevalence of using dental treatment services. …

Emg-Guided Human-Machine Interaction Training Develops New Intermuscular Coordination Patterns In Stroke: A Pilot Study, Gang Seo, Manuel Portilla-Jiménez, Michael Houston, Jeong-Ho Park, Hangil Lee, Sheng Li, Yingchun Zhang, Hyung-Soon Park, Jinsook Roh

Faculty, Staff and Student Publications

Background: Stroke survivors often experience impaired upper extremity motor function due to abnormal muscle synergies. This pilot study evaluated the feasibility and preliminary effectiveness of electromyography-guided human-machine interaction training designed to expand the repertoire of intermuscular coordination patterns and improve upper extremity motor function in chronic stroke survivors.

Methods: Four chronic stroke survivors with mild-to-moderate upper extremity motor impairment and three age-matched healthy controls participated in a six-week electromyography-guided training intervention. Participants practiced selectively activating one elbow flexor muscle while suppressing another (brachioradialis or biceps brachii). Throughout the course of the intervention, the effect of the training on intermuscular coordination, …

Factors Affecting School Readiness And Level Of Distraction Among Black Children During Virtual Learning In The United States, Imani Barnes

Walden Dissertations and Doctoral Studies

The COVID-19 pandemic necessitated an shift to mandatory virtual learning (VL) for kindergarten through grade 12 students, disrupting educational systems globally and exposing systemic inequities. Although researchers had explored health and education disparities separately, they had not adequately examined the intersection of child health, specifically body mass index (BMI) and health-affected ability, with school readiness and level of distraction in VL environments. The purpose of this quantitative, cross-sectional study was to examine associations between BMI, health affected ability, school readiness, and distraction levels among U.S. Black children engaged in VL in the 2020 school year, controlling for gender, age, and …

Quality Improvement (Qi) Project Aimed At Reducing 30-Day Hospital Readmissions For Patients With Congestive Heart Failure (Chf) Through Checklist Implementation, Gary Gutierrez

Seton Hall University Dissertations and Theses (ETDs)

Abstract

Congestive Heart Failure (CHF) remains a leading cause of preventable 30-day hospital readmissions,

especially in outpatient and transitional care settings. This quality improvement (QI) initiative was

launched within a private internal medicine practice in Essex County, New Jersey, to address this issue

by implementing a standardized CHF management checklist. The checklist focused on four key

components: (a) comprehensive medication reconciliation, (b) tailored patient education, (c) timely

follow-up appointments, and (d) improved interdisciplinary communication. By integrating evidence-

based practices into a structured workflow, the QI project aimed to improve care coordination,

empower patients to manage their condition, and reduce preventable …

Structural Basis Of Panx1 Permeation And Positive Modulation By Mefloquine, Yangyang Li, Zheng Ruan, Junuk Lee, Ian Orozco, Edward Zhou, Juan Du, Wei Lü

Department of Biochemistry and Molecular Biology Faculty Papers

Purinergic signaling relies on ATP release through exocytosis and large-pore channels. Large-pore channels permeate both small anions like chloride and large signaling molecules like ATP, but how this broad cargo selectivity is structurally controlled remains elusive. Here we investigate PANX1, a prototypical large-pore channel, and uncover structural plasticity at the extracellular entrance formed by seven tryptophan (W74) residues. The W74 sidechains are flexible, sampling conformations that range from a constricted state permissive only to chloride to a dilated state compatible with ATP. These states are coupled to variable cation-π interactions between W74 and arginine 75 (R75), suggesting a mechanism for …

Structural Birth Defects And Leukemia Risk In Children With Down Syndrome, Ching-Ju Hsu, Jeremy M Schraw, Sonja A Rasmussen, Tiffany M Chambers, Tania A Desrosiers, Chad D Huff, Amanda E Janitz, Russell S Kirby, Eirini Nestoridi, Wendy N Nembhard, Jason L Salemi, Charles Shumate, Jean Paul Tanner, Mahsa M Yazdy, Michael E Scheurer, Karen R Rabin, Philip J Lupo

Faculty, Staff and Students Publications

Birth defects are associated with increased cancer risk in the general pediatric population, yet their impact on leukemia risk in children with Down syndrome (DS) remains uncertain. We assessed this using data from 26,660 children with DS in the Genetic Overlap Between Anomalies and Cancer in Kids Registry Linkage Study. Among them, 71.9% had at least one major birth defect, predominantly involving the cardiac (64.2%), musculoskeletal (21%), and gastrointestinal systems (6.8%). The cumulative incidence of acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) was comparable in children with and without co-occurring defects. Adjusted hazard ratios (aHR) for ALL and …

First-In-Child Phase I Trial Of P-Stat3 Inhibitor Wp1066 In Pediatric Brain Tumor Patients, Robert C Castellino, Hope L Mumme, Andrea T Franson, Bing Yu, M Hope Robinson, Kavita Dhodapkar, Dolly Aguilera, Matthew J Schniederjan, Rohali Keesari, Zhulin He, Manoj Bhasin, Waldemar Priebe, Amy B Heimberger, Tobey J Macdonald

Faculty, Staff and Student Publications

Background: WP1066 is an orally bioavailable, small molecule inhibitor of activated p-STAT3 that has demonstrated preclinical efficacy in pediatric brain tumor models.

Methods: In a first-in-child, single-center, single-arm 3+3 design Phase I clinical trial, ten patients were treated with WP1066 twice daily, Monday-Wednesday-Friday, for 14 days of each 28-day cycle to determine the maximum tolerated dose (MTD)/maximum feasible dose (MFD) of WP1066. Compassionate use treatment with WP1066 in three pediatric patients with H3.3 G34R/V-mutant high-grade glioma (HGG) is also described.

Results: There was no significant toxicity and the MFD was determined to be 8 mg/kg. Treatment-related adverse events were Grade …

Role Of Cellular Stress Responses In Innate Immune Defense Against Acute Respiratory Infections, Amit Sharma

LSU Doctoral Dissertations

The endoplasmic reticulum (ER) stress sensor inositol-requiring enzyme 1α (IRE1α) is an important regulator of innate immune cells. However, its role in pulmonary innate host defenses remains poorly understood. This dissertation elucidates the dual, context-dependent role of IRE1α in host defense against methicillin-resistant Staphylococcus aureus (MRSA) pneumonia. We demonstrate IRE1α’s function as both a detrimental mediator of acute pathology and an essential facilitator of innate immune memory. Our work revealed that acute IRE1α activation during primary MRSA infection is detrimental. In lungs and alveolar macrophages (AMs), IRE1α is activated in response to MRSA infection. Consequently, IRE1α activation triggers a hyperinflammatory …

A Nationwide Registry Study Of Surgical And Patient-Reported Outcomes Following Anterior Cervical Discectomy And Fusion: Part 2 - Cage With Versus Without Local Bone Graft, Daniel De Wilde, Victor Gabriel El-Hajj, Patrick Vigren, Victor E. Staartjes, Elias Atallah, Erik Edström, Adrian Elmi-Terander

Department of Neurosurgery Faculty Papers

BACKGROUND: Local bone grafts are commonly used as filling material in cages during anterior cervical discectomy and fusion (ACDF). Alternatively, cages without filling materials can be used. The literature comparing these approaches is limited, and their respective effects on patient-reported outcomes (PROM) have been scarcely studied. This study was conducted to compare surgical outcomes and PROMs between local bone graft-packed cages and empty cages in ACDF surgery.

METHODS: This observational study utilized data from the Swedish nationwide registry, Swespine. All adults who underwent ACDF between 2006 and 2020 were considered for inclusion. Exclusion criteria included missing baseline or outcome data. …

Delayed Delivery Of Antibiotics By Ultrasound-Mediated Rupture Of Polylactic Acid Pockets: In Vitro And In Vivo Studies, Selin Isguven Billmyer, Priscilla Machado, Ryan Tomlinson, Lauren J. Delaney, Ji-Bin Liu, Alexander H Harris, Eric Mclaughlin, Noreen J. Hickok, Flemming Forsberg

Department of Radiology Faculty Papers

Surgical site infections are a devastating complication of instrumented orthopaedic surgery, particularly in the spine. Bacterial biofilms, once formed on the implant surfaces, exhibit antibiotic tolerance and immune escape, which lead to treatment challenges. Up to 9% of instrumented spine surgeries result in infection, despite the use of systemic antibiotics and local, powdered antibiotics for prophylaxis. The bacteria that survive the initial prophylaxis may be susceptible to a second, high dose of antibiotic prophylaxis prior to establishing at the site. Hence, we designed a local drug delivery system consisting of polylactic acid (PLA) film pockets that can be noninvasively triggered …

Acceptability, Appropriateness, Willingness To Use, And Perceptions Towards Hiv Self-Testing Among Adolescent Girls And Young Women In Rural Northern Uganda: A Baseline Formative Cross-Sectional Study, Ronald Olum, Morrish Obol Okello, Freddy Eric Kitutu, Elvin H Geng, Philippa Musoke

2020-Current year OA Pubs

BACKGROUND: Adolescent girls and young women (AGYW) in Uganda are at higher risk for and bear a significant HIV burden, accounting for 25% of new infections. Despite improved HIV testing services, AGYW in rural areas face barriers to facility-based testing due to stigma, physical access barriers, and confidentiality concerns. This study assessed the acceptability, appropriateness, willingness to use, and perceptions of HIVST among AGYW in Northern Uganda.

METHODS: This cross-sectional study was part of a baseline assessment for a quasi-experimental trial evaluating community-led HIVST among AGYW aged 15-24 years in 5 sub-counties in Omoro District. Data were collected using systematic …

Pxj Volume 12 – Key Theme Summary And Article Index, Patient Experience Journal

Patient Experience Journal

Volume 12 of the Patient Experience Journal showcases a global dedication to advancing human experience in healthcare, illuminating both existing challenges and crucial emerging practices. The content, spanning three issues, emphasizes that improving the human experience is not a temporary initiative but rather the essential foundation for building trust, ensuring safety, facilitating healing, and sustaining organizational resilience. The overarching message of Volume 12 is that human experience is the heart of healthcare. It is actively shaped through shared purpose, design, empathy, communication, and partnership. The journal calls for a future where every voice is heard, every story matters, every …

Effects Of Hambeles (Myrtus Communis L.) Leaf On In Vitro Ruminal Fermentation Parameters, Methane Production And Protozoa Counts, Çağrı Kale, Fatma Özkan, Taylan Aksu, Devrim Saripinar Aksu, Nuriye Tuğba Bingöl, Mehtap Güney, Süleyman Ercüment Önel

The Thai Journal of Veterinary Medicine

Current ruminant nutrition studies are based on improving rumen fermentation to enhance performance and reduce greenhouse gases. For this purpose, the use of herbal-based feed supplements has become widespread. To determine the effects of adding Hambeles (Myrtus communis L.) leaf to some roughage on rumen fermentation parameters by in vitro gas production technique. Corn silage, alfalfa hay and wheat straw were used as roughage. Hambeles leaf was added to roughage at the rate of 0%, 3%, 6%, 9% of the dry matter. According to the data obtained, it was determined that adding 6% and 9% Hambeles leaves to corn …

Core And Characteristic Oral Microorganisms In The Giant Pandas (Ailuropoda Melanoleuca) Suggested Plenty Of Antibiotic Resistance Prevalence: A Mini Review, Han Long, Haifeng Liu, Caiwu Li, Xiaoping Ma, Guangneng Peng, Zhijun Zhong, Chengdong Wang, Ziyao Zhou

The Thai Journal of Veterinary Medicine

The giant panda (Ailuropoda melanoleuca) is a world-recognized rare wildlife endemic to China. Oral microorganisms may cause dental and other systemic diseases. Additionally, antibiotic resistance in this cute mammal may spread widely to travelers. In this mini review, we illustrated the oral core microorganisms of the giant pandas and their characteristics, as well as their prevalence of antibiotic resistance genes. Although there is limited availability in panda sample collection, researchers have made great efforts to find the characteristics of the giant pandas’ oral microbiota, including Enterococcus faecium, Enterococcus faecalis, and Staphylococci, with antibiotic resistance genes optrA …

Evaluating Fall Prevention Outcomes: Fall Rates, Staff Fall Knowledge, And Perceptions On Safety Culture, Priscilla Greco

Student Scholarly Projects

Practice Problem: The practice problem addressed in this project was the elevated fall rates on a 46-bed medical–surgical unit with a reported sentinel fall event, prompting the need to evaluate the current fall prevention program.

PICOT: The PICOT question that guided this project was: In nursing staff on a medical–surgical unit (P), how does the implementation of an evidence-based fall prevention program evaluation using AHRQ tools (I), compared with no formal program evaluation (C), influence staff knowledge, perceptions of safety culture, and fall rates (O) over 8-weeks (T)?

Evidence: Evidence supporting this project emphasized that structured staff education, strong communication, …

Cv: Sophia Orlowski (Radiography), Sophia Orlowski

Rehabilitation and Health Sciences Department Faculty Curricula Vitae

No abstract provided.

Social Media Use And Its Association With Eating-Related Attitudes And Behaviors In Rural University Students, Erin S. Clark

Honors College Theses

Context: Eating disorders (EDs) are psychiatric illnesses wherein atypical patterns of eating induce harmful physical and psychosocial consequences. ED rates have increased globally in recent years, jumping from an estimated 3.5% to 7.8% between 2006 and 2018. ED onset typically occurs in adolescence and early adulthood and results from complex interactions between biological, psychological, and social factors. One such social factor is social media (SM) usage.

Research Design: The present quantitative study examines how measures of SM use (including use intensity, activity, personal perceptions of SM, and initial age of introduction to SM) relate to ED risk among rural university …

Longitudinal Quality Improvement Project To Increase Colorectal Cancer Screening For An Underserved Population In A Resident Physician-Led Primary Care Clinic., Vivek Vardhan Jasti, Sarah N Grebennikov, Mariah Barlow, David Y Lo, Shail M Govani, Miram Chan, Aimee E Willett, Christopher Barlow

Medical Education Articles

BACKGROUND: The overall rates of colorectal cancer (CRC) in the US population have been declining steadily over the past 30 years, in large part due to timely cancer screenings. Despite the emergence of new screening modalities, a large portion of the population has not completed CRC screening in accordance with guidelines. Adequate and timely screening can prevent or detect CRC in earlier stages. Various factors have been identified that influence screening completion. Lower screening rates have been associated with the underserved population, especially in the immigrant community and patients with inadequate access to healthcare. In the USA, primary care clinics …

Patent Searching With Uspto, Derwent Innovation And Lens.Org, Ibis Anette Moreno-Lozano

Day Family Research Lab Workshop Series

No abstract provided.

Patient Preferences When Selecting Their Total Joint Arthroplasty Surgeon: A Multicenter Survey Study, Jake Laverdiere, Danielle Lonati, Swaroopa Vaidya, Gregory Panza, Antonia Chen, Mary Morcos, Yale Fillingham, Jessica Leipman, Molly Hartzler, Jenna Bernstein

Rothman Institute Papers

BACKGROUND: Surgeon selection can influence patient satisfaction, outcomes, and access in total joint arthroplasty (TJA). Awareness of patient preferences enables practices to enhance trust, optimize communication, and improve adherence. While referrals and word-of-mouth recommendations often outweigh online marketing, prospective multicenter research exploring how patients choose their TJA surgeon is limited. The aim of this study was to identify key decision-making factors and how they vary by demographics.

METHODS: This prospective, multicenter cross-sectional survey study included patients undergoing elective total joint arthroplasty at 4 high-volume institutions from January 2024 to 2025. Participants completed a survey on surgeon selection, including how they …

White Nose Syndrome In Bats And Infant Mortality In Georgia, Rhys Medcalfe, Sean Medcalfe, Simon Medcalfe

Journal of the Georgia Public Health Association

Background: White nose syndrome (WNS) is a disease in bats caused by the fungus Pseudogymnoascus destructans that can result in bat mortality rates of over 90%. WNS was discovered in Georgia in 2012 in 3 counties but has continued to spread to 14 counties as of 2023, with P. destructans detected in a further seven. Biodiversity loss has been linked to human health outcomes including infant mortality. Understanding the link between WNS, biodiversity loss, and infant mortality in Georgia is important because Georgia ranks 42^nd out of the 50 states for infant mortality rate.

Methods: Using panel data from …