Medicine and Health Sciences Commons^™

Optimisation Of Estrogen Receptor Subtype-Selectivity Of A 4-Aryl-4h-Chromene Scaffold Previously Identified By Virtual Screening, Miriam Carr, Andrew Knox, Daniel Nevin, Niamh O'Boyle, Shu Wang, Billy Egan, Thomas Mccabe, Brendan Twamley, Daniela Zisterer, David Lloyd, Mary Meegan

Articles

4-Aryl-4H-Chromene derivatives have been previously shown to exhibit anti-proliferative, apoptotic and anti-angiogenic activity in a variety of tumor models in vitro and in vivo generally via activation of caspases through inhibition of tubulin polymerisation. We have previously identified by Virtual Screening (VS) a 4-aryl-4H-chromene scaffold, of which two examples were shown to bind Estrogen Receptor α and β with low nanomolar affinity and <20-fold selectivity for α over β and low micromolar anti-proliferative activity in the MCF-7 cell line. Thus, using the 4-aryl-4H-chromene scaffold as a starting point, a series of compounds with a range of basic arylethers at C-4 and modifications at the C3-ester substituent of the benzopyran ring were synthesised, producing some potent ER antagonists in the MCF-7 cell line which were highly selective for ERα (compound 35; 350-fold selectivity) or ERβ (compound 42; 170-fold selectivity).

Are Maternal Feeding Practices And Mealtime Emotions Associated With Toddlers’ Food Neophobia?A Follow-Up To The Dit-Coombe Hospital Birth Cohort In Ireland, Meijing An, Qianling Zhou, Katherine Younger, Xiyao Liu, John M. Kearney

Articles

This study was conducted to explore the associations between maternal feeding practices,mealtime emotions, as well as maternal food neophobia and toddlers’ food neophobia in Ireland.A follow-up to the Technological University Dublin (DIT)-Coombe Hospital birth cohort wasconducted. Mothers in the original cohort were invited to the present study by telephone calls.Postal questionnaires with stamped addressed envelopes were distributed to those who agreed toparticipate in the study. Toddler food neophobia was assessed by the modified version of the ChildFood Neophobia Scale (CFNS). There were 205 participants included in this study, with a median scoreof child food neophobia of 12. A higher degree …

A Review Of The Influence Of Fathers On Children's Eating Behaviours And Dietary Intake, Stephanie Rahill, Aileen Kennedy, John Kearney

Articles

The role of fathers in child rearing has changed in recent years due to an increase in maternal employment. Despite this, the majority of research has focused on maternal influences and behaviours in relation to child feeding. Therefore, the aims of the narrative review were: 1) to examine the role and responsibility of fathers in child feeding and the factors associated with paternal responsibility in child feeding; 2) to establish how paternal modelling, paternal diets, and paternal feeding practices relate to children's eating behaviours and dietary intake; and 3) to explore the role of maternal perceptions on paternal feeding roles, …

Ethics Committees For Clinical Experimentation At International Level With A Focus On Italy, Zakira Naureen, Tommaso Beccari, Robert S. Marks, Richard Brown, Lorenzo Lorusso, Derek Pheby, Stanislav Miertus, Karen L. Herbst, Liborio Stuppia, Gary T. Henehan, Benedetto Falsini, Ludovica Lumer, Munis Dundar, Matteo Bertelli, International Bioethical Study Group

Articles

Guiding legislation and associated bureaucracy for the ethical review of clinical trials observational studies and food related research play an important role in the competitiveness of a nation in the face of tough global competition to attract sponsors and investigators. This is of particular relevance in the case of multicentre trials and multidisciplinary research. Accordingly, in this report we tried to gather in-depth knowledge of the current role and practices of ethics committees nationwide in both clinical and research settings. This mini-review aims to describe the formulation and organization of ethical committees in Italy in order to provide a focus …

Design, Synthesis, And Biological Evaluation Of Aryl Piperazines With Potential As Antidiabetic Agents Via The Stimulation Of Glucose Uptake And Inhibition Of Nadh:Ubiquinone Oxidoreductase, R. Devine, M. Kelada, S. Leonard, D.S.D. Martin, J.M.D. Walsh, C.J. Breen, R.B. Driver, Gemma K. Kinsella, J.B.C Findlay, J.C. Stephens

Articles

The management of blood glucose levels and the avoidance of diabetic hyperglycemia are common objectives of many therapies in the treatment of diabetes. An aryl piperazine compound 3a (RTC1) has been described as a promoter of glucose uptake, in part through a cellular mechanism that involves inhibition of NADH:ubiquinone oxidoreductase. We report herein the synthesis of 41 derivatives of 3a (RTC1) and a systematic structure-activity-relationship study where a number of compounds were shown to effectively stimulate glucose uptake in vitro and inhibit NADH:ubiquinone oxidoreductase. The hit compound 3a (RTC1) remained the most efficacious with a 2.57 fold increase in glucose …

Editorial: Human-Nature Interactions: Perspectives On Conceptual And Methodological Issues, Tadhg Macintyre, Jürgen Beckmann, Giovanna Calogiuri, Aoife Donnelly, Marc Jones, Christopher R. Madan, Noel Brick, Christopher Gidlow, Mike Rogerson, Mark Nieuwenhuijsen

Articles

Urban agglomerations expose citizens to ever-increasing risks from heat, air pollution, noise stress, and reduced nature connectedness. Concurrently, accumulating evidence suggests various health benefits by exposure to urban natural spaces (World Health Organization, 2016a; Bratman et al., 2019). Existing research suggests an array of benefits of contact with nature which are linked to physical activity (e.g., green exercise), active travel, and residential proximity to greenspace. Psychological benefits appear to be related to mood, well-being, attention and pro-environmental behavior; physiological benefits have been described in terms of increased physical activity, improved cardiovascular parameters, reduced stress hormones, and enhanced immune resources (Bowler …

Effect Of Cold Plasma On Meat Cholesterol And Lipid Oxidation, Juan M. Pérez-Andrés, Janna Cropotova Janna Cropotova, Sabine M. Harrison, Nigel P. Brunton, Patrick J. Cullen, Turid Rustad, Brijesh K. Tiwari

Articles

Cold atmospheric plasma (CAP) is a novel non-thermal technology with potential applications in inactivating microorganisms in food products. However, its impact on food quality is not yet fully understood. The aim of this research is to study the impact of in-package plasma technology on the stability of cholesterol and total lipid in four different types of meat (beef, pork, lamb and chicken breast). Additionally, any changes in the primary or secondary lipid oxidation, which is undesirable from a health perspective, is investigated. CAP was not found to have any impact on the cholesterol or lipid content. However, higher peroxide and …

Using Velocity To Predict The Maximum Dynamic Strength In The Power Clean, G. Gregory Haff, Amador Garcia-Ramos, Lachlan P. James

Research outputs 2014 to 2021

The primary aim of the present study was to examine the commonly performed training exercise for athlete preparation. Twenty-two recreationally trained males (age: 26.3 ± 4.1 y, height: 1.80 ± 0.07 m; body mass (BM): 87.01 ± 13.75 kg, 1-repetitoon maximum(1-RM)/BM: 0.90 ± 0.19 kg) participated in the present study. All subjects had their 1-RM power clean tested with standard procedures. On a separate testing day, subjects performed three repetitions at 30% and 45%, and two repetitions at 70% and 80% of their 1-RM power clean. During all trials during both sessions, peak velocity (PV) and mean velocity (MV) were …

Document Analysis Of Exertional Heat Illness Policies And Guidelines Published By Sports Organisations In Victoria, Australia, Prasanna J. Gamage, Caroline F. Finch, Lauren V. Fortington

Research outputs 2014 to 2021

Objectives To conduct a document and content analysis of exertional heat illness (EHI)-related documents published by sports organisations in Victoria, Australia, in order to determine their scope and evidence base against current international best practice recommendations. Methods A qualitative document and content analysis. Official documents relating to EHI were identified through a search of 22 Victorian sport organisation websites, supplemented by a general internet search. The content of these documents was evaluated against recommendations presented in three current international position statements on prevention and management of EHI. Results A range of document types addressing EHI were identified (n= 25), including …

Autoregulation In Resistance Training: Addressing The Inconsistencies, Leon Greig, Ben Hayden Stephens Hemingway, Rodrigo R. Aspe, Kay Cooper, Paul Comfort, Paul A. Swinton

Research outputs 2014 to 2021

© 2020, The Author(s). Autoregulation is a process that is used to manipulate training based primarily on the measurement of an individual’s performance or their perceived capability to perform. Despite being established as a training framework since the 1940s, there has been limited systematic research investigating its broad utility. Instead, researchers have focused on disparate practices that can be considered specific examples of the broader autoregulation training framework. A primary limitation of previous research includes inconsistent use of key terminology (e.g., adaptation, readiness, fatigue, and response) and associated ambiguity of how to implement different autoregulation strategies. Crucially, this ambiguity in …

What Do We Know About The Nexus Between Culture, Age, Gender And Health Literacy? Implications For Improving The Health And Well-Being Of Young Indigenous Males, Anthony Merlino, James A. Smith, Mick Adams, Jason Bonson, Richard Osborne, Barry Judd, Murray Drummond, David Aanundsen, Jesse Fleay, Benjamin Christie

Research outputs 2014 to 2021

Health literacy, although diversely defined, refers to the abilities, relationships and external environments required for people to successfully promote health. Existing research suggests that health literacy is related to health inequities, including individual and community capacity to navigate health. A diverse range of factors shape health literacy abilities and environments, especially culture, gender and age. However, the nexus between these variables and their cumulative impact on health literacy development remains largely unexplored. Commentary that explores these dynamics among young Indigenous males is particularly scant. In turn, strategies to bridge health equity gaps have been obscured. This article brings together disparate …

Contextualizing Performance Of Coordinated Care Network Of Veteran Services In Virginia, Marina Saitgalina, Donta Council

School of Public Service Faculty Publications

Coordinated care network is an approach to human service delivery that is recognized to improve client outcomes at a reduced cost. However, general mixed findings on the effectiveness of coordinated care networks warrant research contextualization. This article seeks to discover factors influencing the performance of a coordinated care network delivering social services to veterans and their families. The study provides a contextual analysis of a coordinated care network launched in 2016 in southeastern Virginia for two samples of 1,512 and 375 veterans and their families. Results of the regression analyses indicate that initial progress has been made both in efficiency …

Teaching During The Pandemic? An Opportunity To Enhance Curriculum, M. Courtney Hughes, Beverly W. Henry, Michael R. Kushnick

Faculty Articles, Papers, and Other Scholarship

The rapid transition of courses to an emergency remote teaching and learning format at the onset of the COVID-19 pandemic in early 2020 created challenges across the university landscape for faculty and students and, inevitably, affects the future of higher education. We drew upon education theory, evidence-based teaching practices, and insights from a rapid-response survey of academics in the fields of public health, health promotion, and health communication about their perspectives on the impact of COVID-19. This article aims to help educators explore potential strategies to incorporate the lessons and reality of the pandemic into their curriculum. Shifting expectations and …

Identification Of Imiquimod As A Potential Combination For Anti-Cd47 Antibodies In Cancer Therapy, Nicole Brittaney Pang

Scripps Senior Theses

The avenues of targeted immunotherapy offers a promise of less toxic treatment options for those battling different forms of cancer. Specifically, the process of hijacking a patient’s own immune system to fight cancer from within versus using external treatments like chemotherapy which is extremely damaging to the patient. One such avenue includes the usage of monoclonal antibodies as an effective modality for immunotherapy. Cluster of Differentiation 47 (CD47), also known as the ‘don’t eat me signal’, aids in cell proliferation and evasion of phagocytosis and has been found to be a target for stopping tumorigenesis. Previous research has been successful …

Effect Of Unmaskes On Delivering Difficult News Among Residents, Karishma Sharma

Master of Medicine in Internal Medicine

Background: Effective delivery of difficult news to patients and family has been shown to improve the physician-patient relationship, quality of care, and overall patient satisfaction. However, delivery of difficult news (DDN) remains a challenging task for even the most experienced providers. Little has been studied about delivery of difficult news by resident physicians in the sub-Saharan setting. We developed a 4-minute, easily accessible, graphic video using the mnemonic UNMASKES to help improve delivery of difficult news by resident physicians at our institution and their patients. Objective: To determine the impact of a short training video called UNMASKES in helping resident …

Occult Hepatitis B Virus Infection In A Cohort Of Hiv Infected Antiretroviral Therapy Naïve Adults, Adil Suleiman Salyani

Master of Medicine in Internal Medicine

Background: Human immunodeficiency virus (HIV) and hepatitis B virus (HBV) are endemic to sub-Saharan Africa (SSA) with co-infection being common. Infection with HIV is a risk factor for occult hepatitis B virus infection (OBI), defined as presence of HBV deoxyribonucleic acid (DNA) in the absence of hepatitis B surface antigen (HBsAg). Occult hepatitis B virus infection is further classified based on HBV DNA level as true (/mL) or false (≥200 IU/mL). Presence of OBI is associated with development of liver cirrhosis and hepatocellular carcinoma (HCC). Objectives: The primary outcome was to determine the prevalence of OBI in anti-retroviral therapy (ART) …

Utility Of Glasgow-Blatchford Scoring System In Identification Of Low Risk Patients With Upper Gastrointestinal Bleeding In Emergency Departments In Dar Es Salaam Hospitals, Tanzania, Selestin D. Mpiri

Master of Medicine in Internal Medicine

Background: Acute upper gastrointestinal bleeding (UGIB) remains a common cause of visits to the Emergency Department (ED). To stratify the risk of complications, rebleeding, need for clinical intervention, or death, several clinical scores are in use. Glasgow-Blatchford Score (GBS) is an excellent risk assessment tool and has shown to accurately identify patients with a low risk of death or requiring intervention. In urban Tanzania, there is a lack of standardized protocol and a well-validated risk assessment tool for analyzing patients presenting with UGIB symptoms. Good performance of GBS score and its use will help to reduce unnecessary emergency endoscopies and …

Discordance Between Breast Imaging And Histopathology Findings After Ultrasound Guided Core Needle Biopsy, Margaret Mutinda Mwania

Master of Medicine in Imaging and Diagnostic Radiology

Introduction: Breast cancer is the most prevalent cancer among women worldwide with an estimated global incidence of 11.6%. According to the GLOBOCAN factsheet, in 2018 breast cancer incidence in Kenya was 40.3 per 100,000. Early detection and diagnosis of breast cancer has been shown to reduce mortality and increase years of life gained. Breast lesion diagnosis is heavily based on imaging and pathology and typically findings are reported independent of one another. Correlation of imaging findings and pathology after biopsy is found to be of critical importance in detecting possible sampling error, concordance versus discordance, recommend appropriate management and thus …

Von Willebrand Disease Among Women Of African Descent Attending The Aga Khan University Hospital Nairobi, With Menorrhagia, Angela Nabutilu Munoko

Master of Medicine in Clinical Pathology

Introduction: Von Willebrand Disease (VWD) is the most common heritable bleeding disorder with equal prevalence reported across the races. Women are more likely to present with excessive bleeding due to menstruation and child bearing. Studies have found that 5-24% of women presenting with menorrhagia have VWD. Women of African descent are under-represented in studies carried out on Von Willebrand disease and lower prevalence has been reported in this population. VWD has variable penetrance and racial differences in genetic mutations may influence presentation and disease severity. It was predicted that the standardization of the study conditions (case definition of menorrhagia, use …

Vulvodynia, It’S In My Head: Mad Methods Toward Crip Coalition, Renee Dumaresque

Journal of Feminist Scholarship

This article employs a mad transdisciplinary approach to autoethnography to detail vulvodynia — or chronic vulvar pain — within the system of (dis)ability. Through autoethnography, the self operates as a mobile orientation from which to identify and disrupt the colonial rationalities that differentially construct and narrate vulvodynia across sites of madness and disability. Through historical, discursive, and autoethnographic analysis, I locate vulvodynia’s role in various processes of subject, race, and settler-state formation from the nineteenth century up to the neoliberal present.

Dynamic Conformal Arcs For Lung Stereotactic Body Radiation Therapy: A Comparison With Volumetric-Modulated Arc Therapy., Rasmus Bokrantz, Minna Wedenberg, Peter Sandwall

Oncology Articles

This study constitutes a feasibility assessment of dynamic conformal arc (DCA) therapy as an alternative to volumetric-modulated arc therapy (VMAT) for stereotactic body radiation therapy (SBRT) of lung cancer. The rationale for DCA is lower geometric complexity and hence reduced risk for interplay errors induced by respiratory motion. Forward planned DCA and inverse planned DCA based on segment-weight optimization were compared to VMAT for single arc treatments of five lung patients. Analysis of dose-volume histograms and clinical goal fulfillment revealed that DCA can generate satisfactory and near equivalent dosimetric quality to VMAT, except for complex tumor geometries. Segment-weight optimized DCA …

Gynecologic Large Cell Neuroendocrine Carcinoma: A Review, Grant Burkeen, Aman Chauhan, Rohitashva Agrawal, Riva Raiker, Jill M. Kolesar, Lowell B. Anthony, B. Mark Evers, Susanne Arnold

Internal Medicine Faculty Publications

Large cell neuroendocrine carcinomas (LCNEC) are rare, aggressive high-grade neuroendocrine neoplasms within the neuroendocrine cell lineage spectrum. This manuscript provides a detailed review of published literature on LCNEC of gynecological origin. We performed a PubMed search for material available on gynecologic LCNEC. We analyzed 104 unique cases of gynecologic LCNECs, of which 45 were cervical primary, 45 were ovarian, 13 were uterine, and 1 was vaginal. A total of 45 cases of cervical LCNEC were identified with a median age of 36 years. Median overall survival was 16 months. We identified 45 ovarian LCNEC cases in the published literature with …

If At Least The Patient Could Not Be Forgotten About: Communication In The Emergency Department As A Predictor Of Patient Satisfaction, Seiichi Villalona, W. Alex Webb, Carol Boxtha, Cirenio Cervantes, Jason Wilson

College of Medicine & TGH Faculty Publications

Press Ganey survey data are used by institutions to understand patient experiences in the emergency department (ED). The present mixed-methods retrospective cohort study examined the effects of hallway placement, pain management reporting, communication approaches, time spent in the ED, and other demographic variables on predicting satisfaction ratings of doctors, nurses, and overall ED care. A total of 4940 patient responses between January 1, 2012, and December 31, 2017, were analyzed from 2 EDs associated with an academic institution and tertiary care center. Consensus coding was used to qualitatively capture patient responses that relate to communication issues pertaining to care/empathy and …

The Write Stuff - Winter 2020 (Vol. 17, No. 1), Research Medical Library

Write Stuff 2020

• Best practices for sharing confidential materials outside MD Anderson
• 11th edition of the AMA Manual of Style to be published this month
• MD Anderson’s policies on disclosure of foreign relationships
• New NIH grant application instructions and forms coming in spring 2020
• Cabell’s Blacklist
• Unusual terms used in scientific writing and publishing: Hybrid journal and mirror journal

Emotional Regulation Among High School Varsity Basketball Coaches, Dan Ourian

Applied Sport & Performance Psychology | Faculty Dissertations and Theses

As the field of sport psychology has grown, researchers and applied practitioners have turned their attention from working solely with athletes to working with the coaches who lead those athletes. Coaches, with their various roles, constraints and stressors, are performers in their own right, in need of assistance with their mental performance (Giges, Petitpas & Vernacchia, 2004). The present study examined how emotional regulation is valued as a psychological skill among 10 high school varsity basketball coaches. Through semi structured interviews and thematic content analysis, the coaches' view on how emotions impact their coaching practice is explored. Results regarding their …

Kujdesi Infermieror Te Pacientët Në Dializë, Bukurije Berisha

Theses and Dissertations

Objektivi kryesor i këtij hulumtimi është vlerësimi i cilësisë së jetës në dializë e personave që jetojnë me sëmundje renale kronike (SRK). Përmes këtij hulumtimi janë përcaktuar standardet e kujdesit infermieror për pacientët të cilët janë në dializë. Studimi u realizua në Qendrën e Hemodializës në Ferizaj, në të cilën morrën pjesë 53 pacientë, 59% e tyre meshkuj dhe 41% femra, të përzgjedhur në mënyrë rastësove. Pyetësori mbulon aspekte të ndryshme të shëndetit të pacientëve në dializë duke theksuar edhe sjelljet etike dhe njohuritë e stafit infermieror dhe bashkëpunimin e tyre infermier – pacient.

Nga gjetjet e hulumtimit që i …

Dental Practice Success Vol. 6 No. 4, American Dental Association, Publishing Division

Dental Practice Success

No abstract provided.

Dental Practice Success Special Issue: Design Innovation Awards (January 2020), American Dental Association, Publishing Division

Dental Practice Success

No abstract provided.

Identifying Community Physical Activity And Health Resources For Treatment Of Back Pain By Utilizing Members Of A Physical Activity Network, Cara L. Sedney, Treah Haggerty, Sam Zizzi, Patricia Dekeseredy

Faculty & Staff Scholarship

Background

Back pain is one of the leading causes of health care expenditure in the US and is linked to an increased body mass index. Many evidence-based modalities for the prevention and treatment of back pain closely mirror recommendations for weight loss and include physical activity and health maintenance activities (PAHM). The primary aim of this study was to ascertain community assets, and perceptions of the use of PAHM in the treatment of back pain by West Virginia Physical Activity Network (WVPAN) members.

Methods

Participants for the study were recruited from the West Virginia Physical Activity Network. This grassroots organization …

Developing The Rapid Assessment Of Problem Solving For Kids (Raps-K), Emily Phillips

Mahurin Honors College Capstone Experience/Thesis Projects

The Rapid Assessment of Problem Solving (RAPS) was created by Dr. Robert Marshall in order to assess an individuals’ problem solving abilities. This assessment is set up like the popular twenty-questions game and is used to assess adults with cognitive impairments. An administrator chooses a picture from a board of thirty-two pictures and the subject must ask yes or no questions in order to guess the target picture in as few questions as possible. Analysis assesses integration planning scores, question asking efficiency scores, and question types to determine a level of problem solving abilities.

Smith and Jones (2018) used the …