Medicine and Health Sciences Commons^™

Meningitis In Infants ≤60 Days Of Age Diagnosis, Parent Experiences And Potential Improvements In Care And Communication, Eduardo Fleischer

Yale Medicine Thesis Digital Library

Objectives: The aims of this body of work are several fold. Aim 1: To describe the cerebrospinal fluid (CSF) profile of infants ≤60 days old with bacterial meningitis and characterize the clinical and laboratory features of infants with bacterial meningitis who present with no CSF abnormalities. Aim 2: To evaluate the performance characteristics of the BioFire® FilmArray® Meningitis/Encephalitis panel (ME panel), the only Food and Drug Administration (FDA)-cleared multiplexed panel for the evaluation of CSF samples. Aim 3: To identify themes to be included in a parent-reported outcome measure for febrile infants ≤60 days old and to describe the process …

Lifestyle Risk Factor Related Disparities In Oral Cancer Examination In The U.S: A Population-Based Cross-Sectional Study, Aderonke A. Akinkugbe, Dina T. Garcia, Tegwyn H. Brickhouse, Maghboeba Mosavel

Dental Public Health and Policy Publications

Background: Oral cancers account for 3% of annual U.S. cancer diagnosis, 2 in 5 of which are diagnosed late when prognosis is poor. The purpose of this study was to report the population-level prevalence of oral cancer examination among adult smokers and alcohol drinkers and assess if these modifiable lifestyle factors are associated with receiving an oral cancer examination.

Methods: Adult participants ≥30 years (n = 9374) of the 2013–2016 cycles of the National Health and Nutrition Examination Survey were included. Oral cancer examination (yes/no), smoking (never, former, current) and alcohol use (abstainers, former, current) were self-reported. Survey-logistic regression …

Impact Of Making Dental Care Affordable On Quality Of Life In Adults Aged 45 Years And Older, Shillpa Naavaal, Susan O. Griffin, Judith A. Jones

Dental Public Health and Policy Publications

Objective:

The objective of this study was to examine the associations between self-reported ability to afford dental care and quality of life in adults aged 45 years and older.

Method:

We used publicly available cross-sectional data from the 2008 National Health Interview Survey and its oral health supplement for 11,760 adults aged 45+ years. The increased probabilities of reporting dental problems attributable to an inability to afford dental care were estimated from multivariate models and combined with respective dental problem disability weights from the Global Burden of Disease to measure loss in quality of life.

Results:

Prevalence of reported inability …

Self-Reported Oral Health Status Among Adults Aged 40+ Years With And Without Vision Impairment: National Health Interview Survey, 2008, John E. Crews, Chiu-Fang Chou, Shillpa Naavaal, Susan O. Griffin, Jinan B. Saaddine

Dental Public Health and Policy Publications

Purpose: To examine self-reported oral health among adults aged 40 years and older with and without vision impairment.

Design: Cross-sectional, with a nationally representative sample.

Methods: We used publicly available data from the Oral Health Module, last administered in 2008, of the National Health Interview Survey. Outcome variables included fair/poor oral health status, mouth condition compared to others the same age, mouth problems (mouth sores, difficulty eating, dry mouth, bad breath, and/or jaw pain), teeth problems (toothache; broken/missing fillings or teeth; loose, crooked, or stained teeth; and/or bleeding gums), and lack of social participation. Using descriptive statistics and multivariate logistic …

The Effects Of Foodborne Bacteria On Outbreaks, Illnesses, And Hospitalizations In The U.S., Henrietta Ofori-Sampong

Scholarship in Medicine - All Papers

Objective: To investigate the effects of foodborne bacteria on outbreaks, and outbreak-associated illnesses and hospitalizations in the United States (U.S.).

Methods: Aggregate data was obtained from the CDC WONDER (Wide-ranging Online Data for Epidemiologic Research) database showing the number of foodborne outbreaks (1993-2017), and outbreak-associated illnesses (1993-2017) and hospitalizations (1998-2017) caused by foodborne bacteria. Species of bacteria were grouped into 13 genera and 1 other. An Analysis of variance (ANOVA) test was used to compare the mean outbreaks, and outbreak-associated illnesses and hospitalizations for each of the years using the data by species for each year. Results: There was no …

Analysis Of Massive Online Medical Consultation Service Data To Understand Physicians’ Economic Return: Observational Data Mining Study, Jinglu Jiang, Ann-Frances Cameron, Ming Yang

Management and Accounting Faculty Scholarship

Background: Online health care consultation has become increasingly popular and is considered a potential solution to health care resource shortages and inefficient resource distribution. However, many online medical consultation platforms are struggling to attract and retain patients who are willing to pay, and health care providers on the platform have the additional challenge of standing out in a crowd of physicians who can provide comparable services. Objective: This study used machine learning (ML) approaches to mine massive service data to (1) identify the important features that are associated with patient payment, as opposed to free trial–only appointments; (2) explore the …

As Some States Consider Reopening, Ada Offers Ppe Guidance To Dentists (May 21, 2020), American Dental Association

News Releases

This collection includes standard news releases, information kits and other documents distributed for publicity, information, announcements of events, etc. as issued from the ADA. Items included in this collection are archival and any costs, links, contact information, or other figures may be out of date. Please contact the ADA to verify information.

Dr. Jack Ferracane Appointed Founding Editor In Chief Of Ada’S New Open Access Journal, American Dental Association

News Releases

This collection includes standard news releases, information kits and other documents distributed for publicity, information, announcements of events, etc. as issued from the ADA. Items included in this collection are archival and any costs, links, contact information, or other figures may be out of date. Please contact the ADA to verify information.

Dr. Leo E. Rouse Receives 2020 American Dental Association Distinguished Service Award, American Dental Association

News Releases

This collection includes standard news releases, information kits and other documents distributed for publicity, information, announcements of events, etc. as issued from the ADA. Items included in this collection are archival and any costs, links, contact information, or other figures may be out of date. Please contact the ADA to verify information.

Lady A To Headline Ada Fdc Virtual Connect Conference 2020, American Dental Association

News Releases

This collection includes standard news releases, information kits and other documents distributed for publicity, information, announcements of events, etc. as issued from the ADA. Items included in this collection are archival and any costs, links, contact information, or other figures may be out of date. Please contact the ADA to verify information.

New Study Finds Patients Commonly Prescribed Opioids And Antibiotics For Dental Conditions At Emergency Departments, American Dental Association

News Releases

This collection includes standard news releases, information kits and other documents distributed for publicity, information, announcements of events, etc. as issued from the ADA. Items included in this collection are archival and any costs, links, contact information, or other figures may be out of date. Please contact the ADA to verify information.

The Power To Heal Our Communities, American Dental Association

News Releases

This collection includes standard news releases, information kits and other documents distributed for publicity, information, announcements of events, etc. as issued from the ADA. Items included in this collection are archival and any costs, links, contact information, or other figures may be out of date. Please contact the ADA to verify information.

Ada Calls Upon Dentists To Postpone Elective Procedures, American Dental Association

News Releases

This collection includes standard news releases, information kits and other documents distributed for publicity, information, announcements of events, etc. as issued from the ADA. Items included in this collection are archival and any costs, links, contact information, or other figures may be out of date. Please contact the ADA to verify information.

Cdc Guidance For Dental Settings Echoes Ada Guidance, American Dental Association

News Releases

This collection includes standard news releases, information kits and other documents distributed for publicity, information, announcements of events, etc. as issued from the ADA. Items included in this collection are archival and any costs, links, contact information, or other figures may be out of date. Please contact the ADA to verify information.

Fda Awards $1.5 Million Grant To Ada Science And Research Institute, American Dental Association

News Releases

This collection includes standard news releases, information kits and other documents distributed for publicity, information, announcements of events, etc. as issued from the ADA. Items included in this collection are archival and any costs, links, contact information, or other figures may be out of date. Please contact the ADA to verify information.

John Timothy Wright, James Bawden Appointed Next Editor In Chief Of The Jada, American Dental Association

News Releases

This collection includes standard news releases, information kits and other documents distributed for publicity, information, announcements of events, etc. as issued from the ADA. Items included in this collection are archival and any costs, links, contact information, or other figures may be out of date. Please contact the ADA to verify information.

Summary Of Ada Guidance During The Covid-19 Crisis, American Dental Association

News Releases

This collection includes standard news releases, information kits and other documents distributed for publicity, information, announcements of events, etc. as issued from the ADA. Items included in this collection are archival and any costs, links, contact information, or other figures may be out of date. Please contact the ADA to verify information.

The Indiana University School Of Dentistry To Host The 2020 Give Kids A Smile® National Kickoff, American Dental Association

News Releases

This collection includes standard news releases, information kits and other documents distributed for publicity, information, announcements of events, etc. as issued from the ADA. Items included in this collection are archival and any costs, links, contact information, or other figures may be out of date. Please contact the ADA to verify information.

Fluorescent Sensor Arrays Can Predict And Quantify The Composition Of Multicomponent Bacterial Samples, Denis Svechkarev, Marat Sadykov, Lucas J. Houser, Kenneth W. Bayles, Aaron M. Mohs

Journal Articles: Pathology and Microbiology

Fast and reliable identification of infectious disease agents is among the most important challenges for the healthcare system. The discrimination of individual components of mixed infections represents a particularly difficult task. In the current study we further expand the functionality of a ratiometric sensor array technology based on small-molecule environmentally-sensitive organic dyes, which can be successfully applied for the analysis of mixed bacterial samples. Using pattern recognition methods and data from pure bacterial species, we demonstrate that this approach can be used to quantify the composition of mixtures, as well as to predict their components with the accuracy of ~80% …

An Integrated Computational And Experimental Study To Investigate Staphylococcus Aureus Metabolism, Mohammad Mazharul Islam, Vinai Chittezham Thomas, Matthew Van Beek, Jong-Sam Ahn, Abdulelah A. Alqarzaee, Chunyi Zhou, Paul D. Fey, Kenneth W. Bayles, Rajib Saha

Journal Articles: Pathology and Microbiology

Staphylococcus aureus is a metabolically versatile pathogen that colonizes nearly all organs of the human body. A detailed and comprehensive knowledge of staphylococcal metabolism is essential to understand its pathogenesis. To this end, we have reconstructed and experimentally validated an updated and enhanced genome-scale metabolic model of S. aureus USA300_FPR3757. The model combined genome annotation data, reaction stoichiometry, and regulation information from biochemical databases and previous strain-specific models. Reactions in the model were checked and fixed to ensure chemical balance and thermodynamic consistency. To further refine the model, growth assessment of 1920 nonessential mutants from the Nebraska Transposon Mutant Library …

Health Professions Division Catalog_2020-2021, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Loss Of Trp53 (P53) Accelerates Tumorigenesis And Changes The Tumor Spectrum Of Sjl/J Mice., Jane Branca, Benjamin E. Low, Ruth L. Saxl, Jennifer K Sargent, Rosalinda A. Doty, Michael V. Wiles, Beth L Dumont, Muneer G. Hasham

Faculty Research 2020

Known as the guardian of the genome, transformation-related protein 53 (TRP53) is a well -known tumor suppressor. Here, we describe a novel TRP53 deficient mouse model on a tumor prone background-SJL/J mice. The absence of TRP53 (TRP53 nullizygosity) leads to a shift in the tumor spectrum from a non-Hodgkin's-like disease to thymic lymphomas and testicular teratomas at a very rapid tumor onset averaging ~12 weeks of age. In haplotype studies, comparing tumor prone versus tumor resistant Trp53 null mouse strains, we found that other tumor suppressor, DNA repair and/or immune system genes modulate tumor incidence in TRP53 null strains, suggesting …

Deep Functional And Molecular Characterization Of A High-Risk Undifferentiated Pleomorphic Sarcoma., Noah E Berlow, Catherine S Grasso, Michael J Quist, Mingshan Cheng, Regina Gandour-Edwards, Brian S Hernandez, Joel E Michalek, Christopher Ryan, Paul Spellman, Ranadip Pal, Lynn S Million, Mark Renneker, Charles Keller

Faculty Research 2020

Nonrhabdomyosarcoma soft-tissue sarcomas (STSs) are a class of 50+ cancers arising in muscle and soft tissues of children, adolescents, and adults. Rarity of each subtype often precludes subtype-specific preclinical research, leaving many STS patients with limited treatment options should frontline therapy be insufficient. When clinical options are exhausted, personalized therapy assignment approaches may help direct patient care. Here, we report the results of an adult female STS patient with relapsed undifferentiated pleomorphic sarcoma (UPS) who self-drove exploration of a wide array of personalized Clinical Laboratory Improvement Amendments (CLIAs) level and research-level diagnostics, including state of the art genomic, proteomic,

Understanding The Healthcare Experiences And Needs Of African Immigrants In The United States: A Scoping Review, Ogbonnaya I. Omenk, Dennis P. Watson, Hugh C. Hendrie

Scholarship and Professional Work – COPHS

Background: Africans immigrants in the United States are the least-studied immigrant group, despite the research and policy efforts to address health disparities within immigrant communities. Although their healthcare experiences and needs are unique, they are often included in the “black” category, along with other phenotypically-similar groups. This process makes utilizing research data to make critical healthcare decisions specifically targeting African immigrants, difficult. The purpose of this Scoping Review was to examine extant information about African immigrant health in the U.S., in order to develop lines of inquiry using the identified knowledge-gaps.

Methods: Literature published in the English language between 1980 …

Vaping Education In The Adolescent Population, Megan M. Meinders, Morgan Sauvage, Shania Scheidt, Alexa Trakalo

All Electronic Theses and Dissertations

The prevalence of e-cigarette use in the United States is drastically rising, deeming vaping an epidemic. With the surge in the use of e-cigarettes, cases of e-cigarette or vaping product use-associated lung injury (EVALI) are simultaneously increasing. The most common tobacco product used among adolescents are e-cigarettes, posing serious concerns regarding health consequences. Adolescents are unaware of the potential harmful effects of e-cigarette use, due to the lack of vaping education provided in high school curriculums.The purpose of this research project is to educate high school students about the harmful effects of e-cigarette use. The need for vaping education was …

Hepatitis C Education, Testing, And Treatment In Homeless Shelters: Models For Linkage To Care In High-Risk Populations, Erin H. Higley

All Electronic Theses and Dissertations

Background: With the increase of IV drug use, Hepatitis C viral (HCV) infections have increased considerably among the homeless population. The introduction of direct-acting antiviral (DAA) medications has made treating marginalized populations much easier. However, getting homeless patients and people who inject drugs (PWID) linked to care remains a challenge worldwide. More research is needed to ensure that all persons with HCV are able to access treatment regardless of social or economic status. Purpose: The purpose of this critical review of research is to identify models of care for treating HCV among the homeless. This review was done to support …

Aging In Place: Causes And Importance Of Fall Prevention Education, Molly Banks, Danielle Halstead, Mariah Leroux

Critically Appraised Topics

Falls are a significant concern for older community-dwelling adults’ ability to age in place, specifically those who aged 60 and older. Many factors contribute to the risk of falls in older adults that need to be addressed by health care facilities, home health providers, and caretakers. Occupational therapy has a role to educate older adults, as well as health care providers on how to prevent the risk factors of older adults and falls. The purpose of this CAT is to take a deeper look at why this population has so many falls and examine the research addressing education and risk …

Learning To Jump Like Corbin Bleu: The Physics Behind Jump Rope, Caroline Camfield

Mahurin Honors College Capstone Experience/Thesis Projects

This project seeks to determine how engineering can be applied to the sport of jump rope so that athletes may better understand the science behind the sport and apply it to improve their performance in “speed jumping.” This style of jump rope consists of a jumper alternating their feet, with the rope passing under them with each step. Several types of ropes, handles, rope lengths, and widths between a jumper’s handles were tested to determine correlations between each variable and different STEM concept. These findings were then transitioned into a lesson plan so that both the jumpers and coaches could …

Assessing Biomass Fuel Consumption In Kasigau, Kenya As A Predictor Of Hypertension, Conner Hounshell

Mahurin Honors College Capstone Experience/Thesis Projects

Cardiovascular disease is the leading cause of death globally and disproportionately affects low- and middle-income countries, such as Kenya. Hypertension is the leading risk factor for cardiovascular disease and is influenced by a variety of factors such as diet, tobacco use, and genetics. One such factor linked to hypertension is exposure to air pollution, but minimal research exists on the effects of household air pollution. Hypertension that is not related to common Western risk indicators, such as waist-to-hip ratio, body mass indices, and hypercholestorlemia, is prevalent in the community of Kasigau, Kenya, along with the prevalence of risks for household …

Assessing Access To Healthcare For Limited English Proficient Patients, Hannah Bergamini

Mahurin Honors College Capstone Experience/Thesis Projects

Patients with limited English skills often face additional struggles when accessing medical care. These patients, referred to as limited English proficient (LEP) patients, are unable to communicate directly with their physician. This lack of direct communication typically results in unique challenges for the patient and provider. Due to these challenges, LEP patients often have poorer health statuses and experience poorer health outcomes. However, when provided with access to qualified medical interpreters, many of these challenges facing LEP patients can be ameliorated. Therefore, using qualified interpreters is an important component in improving the access to healthcare for LEP patients. To determine …