Medicine and Health Sciences Commons^™

The Systemic Effects Of Blood Flow Restriction Training: A Systematic Review, Alexander Tirko, Bradley Miller, Justin Shipe, Olivia Sumeriski

Student Research Poster Presentations 2020

Background: Blood flow restriction (BFR) training has been reported to have significant benefits on local skeletal muscle growth including increasing local muscle mass, strength, and endurance while exercising with lower resistance. As a result, patients unable to perform traditional resistance training may benefit from this technique. However, it is unclear what effects BFR may have on other body systems, such as cardiovascular/pulmonary. It is important to explore the systemic effects of BFR training to ensure it is safe for use in physical therapy.

Purpose: The purpose of this study was to systematically review the systemic effects of blood flow …

Evaluating The Effects Of Contraceptive Use On Breast Pathology And Tissue Density Using Digital Breast Tomosynthesis, Madison Fleischman

Student Research Poster Presentations 2020

This poster discusses how the long-term use of hormonal contraceptives can affect breast density and pathology, and the efficiency of 3-Dimensional (3D) mammography in evaluating dense breast tissue and detecting these pathologies. The results of research on long term use of estrogen-based hormonal birth control and its effect on breast tissue density and the risk of breast cancer, the relationship between breast tissue density and risk of breast cancer, and the efficiency of 3D vs. 2-dimensional (2D) mammography in screening dense breast tissue and identifying breast pathology are presented. Results of the studies show that long-term exposure to hormonal contraceptives …

Effects Of Yoga On Mindfulness In Pediatric Patients With Oncology Diagnoses Through Guardian Perspectives: A Research Protocol, Victoria Ciszak, Dana Cutler, Gabriella Lamanna, Kristen Ogonowski

Student Research Poster Presentations 2020

Abstract:

Background: Yoga practice is commonly utilized by physical therapists in order to promote physical and mental health. In populations with a poorer prognosis, mindfulness and overall well-being becomes increasingly important. In particular, the pediatric cancer population requires an intervention that keeps these emotional needs in mind. Because children are physically and mentally developing throughout their oncology treatments, it is crucial that a comprehensive psychosocial treatment plan is initiated. Yoga can fill this need as it has elements that influence behavior and physical development.

Objective: The aim of this protocol paper is to determine all necessary procedures for future …

Staging Of Twin-To-Twin Transfusion Syndrome Using Ultrasound, Mikayla Catherine Girard

Student Research Poster Presentations 2020

Twin-to-twin transfusion syndrome (TTTS) is a rare condition found in identical twins in which the fetuses share a placenta. It is diagnosed between 16-24 weeks of gestation using ultrasound imaging and the Quintero staging system. The Quintero staging system includes 5 stages, which are categorized by sonographic findings to include abnormal Doppler findings, amount of amniotic fluid, as well as determining which twin is the recipient and which is the donor. The last stage determines if fetal demise in one or both twins has occurred. Dr. Quintero’s staging system has led to an agreement on the condition of the fetuses, …

The Effects Of Rhythmic Exercise On Reaction Time And Balance In Community-Dwelling Older Adults: A Protocol For A Single-Session, Pretest/Posttest Study, Joseph Levandowski, Anthony D'Eliseo, Jacob Klein, Damian Pierontoni

Student Research Poster Presentations 2020

Dancing, both as a therapeutic technique and a recreational hobby, has been widely implemented as an exercise modality in order to improve both functional and metabolic outcomes, and its concepts have been applied to the older adult population (65+). The act of dancing encompasses various rhythmic and repetitive motions within functional movement patterns that can have a direct impact on balance, endurance performance, functional outcome measures, and reducing the incidence of falls within this population. A majority of dance programs and research studies concerning dance techniques have been centered at viewing its effects and outcomes that occur following an extended …

The Effects Of Eyes Open And Eyes Closed Balance Training On Balance Outcome Scores In Individuals Identified As Having Chronic Ankle Instability: A Protocol Paper, Chris Perry Spt, Mitch Haney Spt, Chris Rehrig Spt, Greg Shultz Spt, Josh Wilkes Mspt

Student Research Poster Presentations 2020

Background: Ankle injuries, including ankle sprains, are one of the most common injuries in the United States. Research has found that over $1000 is spent on average when treating sprains, along with recreational activities in addition to the cost of time off of work or school.^1-2 Balance training has previously been shown to be an effective form of treatment for chronic ankle instability.⁶ The removal of visual input is often a progression used in clinical settings when performing balance training, however there is a gap in the literature regarding the efficacy of eyes closed balance training when compared …

The Effects Of Medical Marijuana On Common Symptoms Seen In Individuals With Multiple Sclerosis: A Systematic Review, Kailee Crockett, Rebecca Fiorillo, Mckenzie Ruffing, Kristina Dorkoski, Heather Fritz

Student Research Poster Presentations 2020

Background: Due to Multiple Sclerosis (MS) being one of the most common neurological disorders in young adults, it is essential that as future health care professionals, we are educated on different types of alternative treatments. Recent research has shown that individuals with MS are open to considering medical marijuana as a treatment for common symptoms associated with this disease. This population, among others, would benefit from continued research on this topic to further prove its effectiveness for symptom relief.

Purpose: The purpose of this study was to systematically review the existing literature regarding the effectiveness of medical cannabis in treating …

Effectiveness Of Physical Exercise In Treating Depression Versus Conventional Treatments: A Systematic Review, Julianne Ferrie, Coleby Charlier

Student Research Poster Presentations 2020

Purpose: This systematic review was done to compare the effects of physical exercise on depression versus the standard treatments most patients who are diagnosed with depression receive, which includes antidepressant medication and cognitive behavioral therapy. There is not currently a collective source that summarizes the various studies on this topic within the physical therapy world. Our article compiles relevant information that supports physical exercise as an alternative treatment for individuals who have been diagnosed with depression. We sampled randomized control studies and prospective cohort studies for data and results, and systematic reviews for supporting information. Our research will be a …

The Development And Trial Of Systematic Visual Search: A Visual Inspection Method Designed To Improve Current Workplace Risk Assessment Practice, Victor Hrymak, Jan Devries

Reports

Visual inspection is a core element in hazard identification. However, poorly conducted visual inspections are problematical for workplace inspection practice as observable hazards that should be seen, are often missed. To address this problem, a novel method; systematic visual search, was developed and tested under randomised controlled trial conditions using commercial kitchens as workplaces. A total of 211 participants were recruited and in the control condition, N = 104 conducted their visual inspection as normal. In the experimental condition, N = 107 received training in the use of systematic visual search. Control group participants were only able to identify a …

Cartel Del Mes Nacional De La Salud Dental Infantil "El Fluoruro En El Agua Previene Las Caries" [Spanish Language Version: Fluoride In Water Prevents Cavities] (2020), American Dental Association Foundation

National Children's Dental Health Month

No abstract provided.

Motor Performance And Quality Of Life In A Community Exercise Program For Parkinson Disease, Elizabeth A. Stiles, Karen M. Jaffe, Catherine E. Schwartz, Benjamin M. Rossi, David E. Riley

2020 Faculty Bibliography

We investigated the effect of a comprehensive community program composed of exercise, mindfulness practice, and education on motor function and quality of life in individuals with Parkinson disease (PD). Thirty-six participants completed physical and quality-of-life assessments independently at baseline and 12 months. Physical assessments showed stability or improvement in functional mobility, integrated strength, and walking ability over the 1-year interval. PDQ-39 measures showed improvement in 6 of 8 indices: mobility, activities of daily living, emotional well-being, stigma reduction, social support, and bodily discomfort. Our results demonstrate the effectiveness of exercise, mindfulness, and education in community and group settings.

Caring Minds, Uthealth Cizik School Of Nursing

Caring Minds

No abstract provided.

Evaluation Of Global Health Capacity Building Initiatives In Low-And Middle-Income Countries: A Systematic Review, Hady Naal, Maria El Koussa, Melissa El Hamouch, Layal Hneiny, Shadi Saeh

Faculty Publications

Background Low- and middle-income countries (LMICs) are in dire need to improve their health outcomes. Although Global Health Capacity Building (GHCB) initiatives are recommended approaches, they risk being ineffective in the absence of standardized evaluation methods. This study systematically reviews evaluation approaches for GHCB initiatives in LMICs. Methods We searched the Medline (OVID), PubMed, Scopus, and Embase.com databases for studies reporting evaluation of a GHCB initiative in a LMIC from January 1, 2009 until August 15, 2019. To differentiate them from intervention, prevention, and awareness initiatives, included articles reported at least one approach to evaluate their learning modality. We excluded …

College Of Nursing, Winter 2020, Matt Schmidt, Christine Delfanian, Dave Graves, Elissa Dickey

College of Nursing Magazine

FEATURES
[Page] 2 Partnering with CareSpan
COLLEGE NEWS
[Page] 6 Administrative changes
[Page] 7 Horsley appointed
[Page] 8 Tribal palliative care programs
[Page] 9 Leadership cohort
[Page] 10 Olson completes 20th year
[Page] 12 Johnson honored
ALUMNI NEWS
[Page] 13 Bohnenkamp receives award
STUDENT NEWS
[Page] 14 Mercer leads ROTC unit
[Page] 15 ROTC gives Rohlfs experience
[Page] 16 Cancer can't stop DNP grad
[Page] 18 Accelerating students' dream careers
SDSU FOUNDATION
[Page] 20 Decision based on commitment

Jackrabbits Script & Scope, Winter 2020, College Of Pharmacy And Allied Health Professions

Jackrabbits Script and Scope (Formerly called College of Pharmacy and Allied Health Professions Magazine)

[Page] 4 Haarberg Chair in Cancer Research
[Page] 7 Opioid Addiction Treatment
[Page] 8 Medication Adherence
[Page] 9 Nyberg Breaks Ground
[Page] 10 New Tumor Model Developed
[Page] 12 Scholarships
[Page] 14 Medical Laboratory Science White Coat
[Page] 16 Distinguished Alum Berry Markl
[Page] 17 Remembering Stanley Shaw
[Page] 18 Presenting at Congressional Briefing
[Page] 20 New Faculty/Staff
[Page] 23 Quiz Bowl Standouts
[Page] 24 Student Tabbed for Elite Program
[Page] 25 Kuddos to Gamma Kappa Chapter
[Page] 26 Rising High in Kappa Psi
[Page] 27 Fall Convocation & Research Day
[Page] 28 Academic Assessment
[Page] 29 Department of Allied …

The Safety And Efficacy Of Antidepressant Use In The Adolescent Population, Jason Marcello

Physician Assistant Scholarly Project Posters

This literature review was conducted to determine the safety and efficacy of antidepressants in the adolescent population based on the currently available research. Specifically, are antidepressants safe and efficacious in treating depression in adolescents and is their use associated with increased risk of suicide. Data was collected by searching medical databases including: Clinical Key, CINAHL Complete, PsycINFO, PubMed, DynaMed Plus, and Cochrane Review. The review of the literature included systematic reviews, metaanalysis, cross-sectional, longitudinal, randomized control trials, and survey methods. All literature works selected were published within the past ten years. Upon analysis, the literature showed a significant increase in …

Treatment Option Decision Making For Low-Grade Prostate Cancer, Janene Witherite

Physician Assistant Scholarly Project Posters

Prostate cancer (PCa) is the second most common cancer, among men, in the United States.

 Low-grade PCa is defined by; lack of metastasis outside the prostate (M0), no lymph node involvement (N0), tumor staging up to T2a, a PSA of less than 10 ng/ml, a Gleason score of less than 6, and no more than two of the 10-12 tissue samples (each composed of less than 50% cancer cells) of the 10-12 samples taken.

 Four treatment options exist for low-grade PCa patients: active surveillance (AS), external beam radiotherapy (EBRT), brachytherapy, and radical prostatectomy (RP), all of which cause …

Genetic Interactions Affect Lung Function In Patients With Systemic Sclerosis., Anna L. Tyler, J Matthew Mahoney, Gregory W. Carter

Faculty Research 2020

Scleroderma, or systemic sclerosis (SSc), is an autoimmune disease characterized by progressive fibrosis of the skin and internal organs. The most common cause of death in people with SSc is lung disease, but the pathogenesis of lung disease in SSc is insufficiently understood to devise specific treatment strategies. Developing targeted treatments requires not only the identification of molecular processes involved in SSc-associated lung disease, but also understanding of how these processes interact to drive pathology. One potentially powerful approach is to identify alleles that interact genetically to influence lung outcomes in patients with SSc. Analysis of interactions, rather than individual …

The Chironian 2020, New York Medical College

The Chironian

No abstract provided.

Suicidal Risk Education In Hospice Care, Shannon Jones

Doctor of Nursing Practice Projects

It is well-documented that oncology patients experience greater rates of suicidality including suicidal ideation, actions, or completions, as compared to the general population. The small, rural county which was the setting for this project has a higher rate of lung and colon cancers as compared to regional, state, and national rates. A review of the literature revealed best practices for suicide screening including universal education and screening and targeted education and screening for at-risk populations. The rate for suicides in the county is also higher than the rates for the region, state, and nation. The purpose of this project was …

Ua35/3 Memoranda, Wku Provost

WKU Administration Documents

2020 memoranda issued by the WKU Provost to faculty & staff via email.

• Center for Innovative Teaching & Learning January Workshops
• Fall to Fall Retention of All FFY as of Census by Selected Categories
• Updates fromt the Provost
• COVID-19
• COVID-19 or Coronavirus Update
• COVID-19 Update from the Provost's Office
• Announcing the 2020 College Faculty Award Winners
• WKU Announces New Associate Provost for Research & Graduate Education
• Budget Communication
• Summer School Updates from the Provost
• Amendment to PDF Policy
• FY2020-21 Budget Executive Committee Recommendations
• Provost's Message

Monitoring The Biochemical Changes Occuring To Human Keratinocytes Exposed To Solar Radiation By Raman Spectroscopy, Ulises Lopez-Gonzalez, Alan Casey, Hugh Byrne

Articles

Solar radiation exposure is recognised to be a significant contributor to the development of skin cancer. Monitoring the simultaneous and consecutive mechanisms of interaction could provide a greater understanding of the process of photocarcinogenesis. This work presents an analysis of the biochemical and morphological changes occurring to immortalised human epithelial keratinocyte (HaCaT) cell cultures exposed to simulated solar radiation (SSR). Cell viability was monitored with the aid of the Alamar Blue assay, morphological examination was done with haematoxylin and eosin staining (H&E) and changes to the biochemical constituents (nucleic acids and proteins) as a result of the radiation insult were …

In Vitro Label Free Raman Microspectroscopic Analysis To Monitor The Uptake, Fate And Impacts Of Nanoparticle Based Materials, Hugh Byrne, Franck Bonnier, Esen Efeoglu, Caroline Moore, Jennifer Mcintyre

Articles

The continued emergence of nanoscale materials for nanoparticle-based therapy, sensing and imaging, as well as their more general adoption in a broad range of industrial applications, has placed increasing demands on the ability to assess their interactions and impacts at a cellular and subcellular level, both in terms of potentially beneficial and detrimental effects. Notably, however, many such materials have been shown to interfere with conventional in vitro cellular assays that record only a single colorimetric endpoint, challenging the ability to rapidly screen cytological responses. As an alternative, Raman microspectroscopy can spatially profile the biochemical content of cells, and any …

Chemical Space Exploration Around Thieno[3,2-D]Pyrimidin-4(3h)-One Scaffold Led To A Novel Class Of Highly Active Clostridium Difficile Inhibitors, Xuwei Shao

Theses and Dissertations

Clostridium difficile infection (CDI) is the leading cause of healthcare-associated infection in the United States. Therefore, development of novel treatments for CDI is a high priority. Toward this goal, we began in vitro screening of a structurally diverse in-house library of 67 compounds against two pathogenic C. difficile strains (ATCC BAA 1870 and ATCC 43255), which yielded a hit compound, 2-methyl-8-nitroquinazolin-4(3H)-one (2) with moderate potency (MIC = 312/156 µM). Optimization of 2 gave lead compound 6a (2-methyl-7-nitrothieno[3,2-d]pyrimidin-4(3H)-one) with improved potency (MIC = 19/38 µM), selectivity over normal gut microflora, CC50s >606 µM against mammalian cell lines, and acceptable stability in …

Nvestigation Of Dissolution And Dispersion Behavior Of Ritonavir From Amorphous Solid Dispersion, Nitprapa Siriwannakij

Theses and Dissertations

The aim of this study was to develop ritonavir amorphous solid dispersion (ASD) formulation, investigate its aqueous dissolution and dispersion behavior, and predict potential pharmacokinetic parameters by in-silico modeling. The binary/ternary ASDs of ritonavir with PVPVA or HPMCAS-MG in the absence or presence of surfactants were prepared by using the hot-melt extrusion method. The amount of ritonavir was fixed at 20 %w/w, while amount of polymer and surfactant in the formulation was varied. The film-casting technique was used to confirm the miscibility of drug and polymer in the absence and presence of surfactant in different formulations. PXRD and DSC analyze …

Continuous Salt Synthesis And Granulation Using Single Step Twin Screw Extrusion Process, Jaydip Vasoya

Theses and Dissertations

In the present investigation, a continuous, and novel organic solvent-free approach for the synthesis of pharmaceutical salts using the twin screw extruder (TSE) is reported. Although the method offers distinct advantages such as solvent free synthesis and short processing time over the conventional salt synthesis, the produced salts usually require further processing into granules before they can be compressed into tablets or filled into capsules, which makes the final product manufacturing non-continuous. This report, for the first time, describes a process of combining salt synthesis and granulation into a single-step using a TSE. Cinnarizine, a model poorly water-soluble weakly basic …

Oil/Water Nanoemulsion Biodistribution In Mice Upon Intravenous Administration, Jiayi Chen

Theses and Dissertations

The present study aimed to explore the biodistribution of O/W nanoemulsions (NE) upon intravenous administration. Three NEs were prepared with distinctive droplet sizes: SE (29 ± 1 nm), ME (214 ± 2 nm) and LE (883 ± 16 nm) without overlapping of the size distribution. Kolliphor® HS15 was used as the only surfactant for these three NEs, so that their droplets had similar surface structure. The NEs droplet size was stable under room temperature for minimum 3 days in phosphate buffer saline (PBS) and in mice plasma in vitro for 4-hour at 37°C. A lipophilic fluorescent dye, 1, 1’-dioctadecyl-3, 3, …

Development, Evaluation And Application Of Insulin Solution And Film Dosage Forms For Sublingual Administration, Anuja Paprikar

Theses and Dissertations

The major barrier for sublingual absorption of large molecules like insulin is low permeability owing to the hydrophilic nature of insulin. One approach to overcome this barrier is to sublingually co-administer insulin with permeation enhancers (HPβCD and poloxamer 188). In vitro performance of permeation enhancers was screened across cellulose acetate membrane to select the concentrations of both enhancers, which were further evaluated across four models (MatTek tissue model, MDCK cell line, rat and porcine esophagus). The insulin solution with combination of HPβCD (5%) and poloxamer 188 (0.5%) indicates higher permeation as compared to that of only insulin across all the …

Chemical Synthesis And Evaluation Of Azotochelin Analogs As Anticancer Agents And Their Ability To Reverse Anticancer Drug Resistance, Nishant Karadkhelkar

Theses and Dissertations

Cancer has been plaguing the humanity for several decades. In the meanwhile, multi-drug resistance (MDR) is causing abatement of effective therapeutic drugs, necessitating discovery of new class of anticancer agents. Natural products have been proved to be a promising source of structurally new anticancer agents. A specific class of bacterial secondary metabolites, named siderophores have been explored as potential anticancer agents. Enterobactin is one of the most studied siderophores as a potential anticancer agent. Azotochelin is a structurally similar but structurally simpler siderophore compared to enterobactin. Our research project focused on the evaluation of the structure activity relationship assessment of …

Food Insecurity And Covid-19 Infographic, Community And Family Institute

COVID-19

Infographic on food insecurity and COVID-19 in America.