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Articles 154321 - 154350 of 325780

Full-Text Articles in Medicine and Health Sciences

Clinical Management Of Hyperkalemia, B. F. Palmer, J. J. Carrero, D. J. Clegg, G. B. Colbert, M. Emmett, S. Fishbane, D. J. Hain, E. Lerma, M. Onuigbo, M. R. Weir, +3 Additional Authors Jan 2020

Clinical Management Of Hyperkalemia, B. F. Palmer, J. J. Carrero, D. J. Clegg, G. B. Colbert, M. Emmett, S. Fishbane, D. J. Hain, E. Lerma, M. Onuigbo, M. R. Weir, +3 Additional Authors

Journal Articles

© 2020 Mayo Foundation for Medical Education and Research Hyperkalemia is an electrolyte abnormality with potentially life-threatening consequences. Despite various guidelines, no universally accepted consensus exists on best practices for hyperkalemia monitoring, with variations in precise potassium (K+) concentration thresholds or for the management of acute or chronic hyperkalemia. Based on the available evidence, this review identifies several critical issues and unmet needs with regard to the management of hyperkalemia. Real-world studies are needed for a better understanding of the prevalence of hyperkalemia outside the clinical trial setting. There is a need to improve effective management of hyperkalemia, including classification …

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Cortical Encoding Of Melodic Expectations In Human Temporal Cortex, G. M. Di Liberto, C. Pelofi, R. Bianco, P. Patel, A. D. Mehta, J. L. Herrero, A. De Cheveigne, S. Shamma, N. Mesgarani Jan 2020

Cortical Encoding Of Melodic Expectations In Human Temporal Cortex, G. M. Di Liberto, C. Pelofi, R. Bianco, P. Patel, A. D. Mehta, J. L. Herrero, A. De Cheveigne, S. Shamma, N. Mesgarani

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No abstract provided.

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Recommendations For Core Critical Care Ultrasound Competencies As A Part Of Specialist Training In Multidisciplinary Intensive Care: A Framework Proposed By The European Society Of Intensive Care Medicine (Esicm), A. Wong, L. Galarza, L. Forni, D. De Backer, M. Slama, B. Cholley, P. Mayo, A. Mclean, F. Duška, +17 Additional Authors Jan 2020

Recommendations For Core Critical Care Ultrasound Competencies As A Part Of Specialist Training In Multidisciplinary Intensive Care: A Framework Proposed By The European Society Of Intensive Care Medicine (Esicm), A. Wong, L. Galarza, L. Forni, D. De Backer, M. Slama, B. Cholley, P. Mayo, A. Mclean, F. Duška, +17 Additional Authors

Journal Articles

© 2020 The Author(s). Critical care ultrasound (CCUS) is an essential component of intensive care practice. Although existing international guidelines have focused on training principles and determining competency in CCUS, few countries have managed to operationalize this guidance into an accessible, well-structured programme for clinicians training in multidisciplinary intensive care. We seek to update and reaffirm appropriate CCUS scope so that it may be integrated into the international Competency-based Training in Intensive Care Medicine. The resulting recommendations offer the most contemporary and evolved set of core CCUS competencies for an intensive care clinician yet described. Importantly, we discuss the rationale …

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Submaximal Angioplasty For Symptomatic Intracranial Atherosclerotic Disease: A Meta-Analysis Of Peri-Procedural And Long-Term Risk, C. J. Stapleton, Y. F. Chen, H. Shallwani, K. Vakharia, T. N. Turan, H. H. Woo, C. P. Derdeyn, F. T. Charbel, A. H. Siddiqui, S. Amin-Hanjani Jan 2020

Submaximal Angioplasty For Symptomatic Intracranial Atherosclerotic Disease: A Meta-Analysis Of Peri-Procedural And Long-Term Risk, C. J. Stapleton, Y. F. Chen, H. Shallwani, K. Vakharia, T. N. Turan, H. H. Woo, C. P. Derdeyn, F. T. Charbel, A. H. Siddiqui, S. Amin-Hanjani

Journal Articles

© 2019 by the Congress of Neurological Surgeons. BACKGROUND: Symptomatic intracranial atherosclerotic disease (ICAD) is an important cause of stroke. Although the high periprocedural risk of intracranial stenting from recent randomized studies has dampened enthusiasm for such interventions, submaximal angioplasty without stenting may represent a safer endovascular treatment option. OBJECTIVE: To examine the periprocedural and long-term risks associated with submaximal angioplasty for ICAD based on the available literature. METHODS: All English language studies of intracranial angioplasty for ICAD were screened. Inclusion criteria were as follows: ≥ 5 patients, intervention with submaximal angioplasty alone, and identifiable periprocedural (30-d) outcomes. Analysis was …

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Role Of Sulfonylurea Receptor 1 And Glibenclamide In Traumatic Brain Injury: A Review Of The Evidence, R. M. Jha, J. Bell, G. Citerio, J. C. Hemphill, W. T. Kimberly, R. K. Narayan, J. Sahuquillo, K. N. Sheth, J. M. Simard Jan 2020

Role Of Sulfonylurea Receptor 1 And Glibenclamide In Traumatic Brain Injury: A Review Of The Evidence, R. M. Jha, J. Bell, G. Citerio, J. C. Hemphill, W. T. Kimberly, R. K. Narayan, J. Sahuquillo, K. N. Sheth, J. M. Simard

Journal Articles

No abstract provided.

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A Model For Focal Seizure Onset, Propagation, Evolution, And Progression, J. Liou, E. H. Smith, L. M. Bateman, S. L. Bruce, G. M. Mckhann, R. R. Goodman, R. G. Emerson, C. A. Schevon, L. F. Abbott Jan 2020

A Model For Focal Seizure Onset, Propagation, Evolution, And Progression, J. Liou, E. H. Smith, L. M. Bateman, S. L. Bruce, G. M. Mckhann, R. R. Goodman, R. G. Emerson, C. A. Schevon, L. F. Abbott

Journal Articles

No abstract provided.

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Identification Of A Brainstem Locus That Inhibits Tumor Necrosis Factor., A. M. Kressel, T. Tsaava, Y. A. Levine, E. H. Chang, M. E. Addorisio, Q. Chang, B. J. Burbach, V. A. Pavlov, S. S. Chavan, K. J. Tracey, +4 Additional Authors Jan 2020

Identification Of A Brainstem Locus That Inhibits Tumor Necrosis Factor., A. M. Kressel, T. Tsaava, Y. A. Levine, E. H. Chang, M. E. Addorisio, Q. Chang, B. J. Burbach, V. A. Pavlov, S. S. Chavan, K. J. Tracey, +4 Additional Authors

Journal Articles

In the brain, compact clusters of neuron cell bodies, termed nuclei, are essential for maintaining parameters of host physiology within a narrow range optimal for health. Neurons residing in the brainstem dorsal motor nucleus (DMN) project in the vagus nerve to communicate with the lungs, liver, gastrointestinal tract, and other organs. Vagus nerve-mediated reflexes also control immune system responses to infection and injury by inhibiting the production of tumor necrosis factor (TNF) and other cytokines in the spleen, although the function of DMN neurons in regulating TNF release is not known. Here, optogenetics and functional mapping reveal cholinergic neurons in …

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The Hydrogel Endovascular Aneurysm Treatment Trial (Heat): A Randomized Controlled Trial Of The Second-Generation Hydrogel Coil, B. R. Bendok, K. R. Abi-Aad, J. D. Ward, J. F. Kniss, M. J. Kwasny, R. J. Rahme, S. G. Aoun, T. Y. El Ahmadieh, H. H. Woo, J. Hartman, +57 Additional Authors Jan 2020

The Hydrogel Endovascular Aneurysm Treatment Trial (Heat): A Randomized Controlled Trial Of The Second-Generation Hydrogel Coil, B. R. Bendok, K. R. Abi-Aad, J. D. Ward, J. F. Kniss, M. J. Kwasny, R. J. Rahme, S. G. Aoun, T. Y. El Ahmadieh, H. H. Woo, J. Hartman, +57 Additional Authors

Journal Articles

© 2020 Congress of Neurological Surgeons 2020. BACKGROUND: Aneurysm recurrence after coiling has been associated with aneurysm growth, (re)hemorrhage, and a greater need for follow-up. The second-generation HydroCoil Embolic System (HES; MicroVention, Inc) consists of a platinum core with integrated hydrogel and was developed to reduce recurrence through enhancing packing density and healing within the aneurysm. OBJECTIVE: To compare recurrence between the second-generation HES and bare platinum coil (BPC) in the new-generation Hydrogel Endovascular Aneurysm Treatment Trial (HEAT). METHODS: HEAT is a randomized, controlled trial that enrolled subjects with ruptured or unruptured 3- to 14-mm intracranial aneurysms amenable to coiling. …

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A Management Algorithm For Adult Patients With Both Brain Oxygen And Intracranial Pressure Monitoring: The Seattle International Severe Traumatic Brain Injury Consensus Conference (Sibicc), R. Chesnut, S. Aguilera, A. Buki, E. Bulger, G. Citerio, D. J. Cooper, R. D. Arrastia, M. Diringer, J. S. Ullman, G. W. Hawryluk, +32 Additional Authors Jan 2020

A Management Algorithm For Adult Patients With Both Brain Oxygen And Intracranial Pressure Monitoring: The Seattle International Severe Traumatic Brain Injury Consensus Conference (Sibicc), R. Chesnut, S. Aguilera, A. Buki, E. Bulger, G. Citerio, D. J. Cooper, R. D. Arrastia, M. Diringer, J. S. Ullman, G. W. Hawryluk, +32 Additional Authors

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No abstract provided.

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Ass1 Overexpression: A Hallmark Of Sonic Hedgehog Hepatocellular Adenomas; Recommendations For Clinical Practice., M. Sala, D. Gonzales, T. Leste-Lasserre, N. Dugot-Senant, V. Paradis, S. Di Tommaso, J. Dupuy, V. Pitard, C. Fan, F. Saltel, +26 Additional Authors Jan 2020

Ass1 Overexpression: A Hallmark Of Sonic Hedgehog Hepatocellular Adenomas; Recommendations For Clinical Practice., M. Sala, D. Gonzales, T. Leste-Lasserre, N. Dugot-Senant, V. Paradis, S. Di Tommaso, J. Dupuy, V. Pitard, C. Fan, F. Saltel, +26 Additional Authors

Journal Articles

Until recently, 10% of hepatocellular adenomas (HCAs) remained unclassified (UHCA). Among the UHCAs, the sonic hedgehog HCA (shHCA) was defined by focal deletions that fuse the promoter of Inhibin beta E chain with GLI1. Prostaglandin D2 synthase was proposed as immunomarker. In parallel, our previous work using proteomic analysis showed that most UHCAs constitute a homogeneous subtype associated with overexpression of argininosuccinate synthase (ASS1). To clarify the use of ASS1 in the HCA classification and avoid misinterpretations of the immunohistochemical staining, the aims of this work were to study (1) the link between shHCA and ASS1 overexpression and (2) the …

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The Value Proposition For Pathologists: A Population Health Approach, B. S. Ducatman, A. M. Ducatman, J. M. Crawford, M. Laposata, F. Sanfilippo Jan 2020

The Value Proposition For Pathologists: A Population Health Approach, B. S. Ducatman, A. M. Ducatman, J. M. Crawford, M. Laposata, F. Sanfilippo

Journal Articles

© The Author(s) 2020. The transition to a value-based payment system offers pathologists the opportunity to play an increased role in population health by improving outcomes and safety as well as reducing costs. Although laboratory testing itself accounts for a small portion of health-care spending, laboratory data have significant downstream effects in patient management as well as diagnosis. Pathologists currently are heavily engaged in precision medicine, use of laboratory and pathology test results (including autopsy data) to reduce diagnostic errors, and play leading roles in diagnostic management teams. Additionally, pathologists can use aggregate laboratory data to monitor the health of …

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Molecular Pathology Economics 101: An Overview Of Molecular Diagnostics Coding, Coverage, And Reimbursement A Report Of The Association For Molecular Pathology, A. N. Sireci, J. L. Patel, L. Joseph, M. C. Hiemenz, O. C. Rosca, S. K. Caughron, S. A. Thibault-Sennett, T. L. Burke, D. L. Aisner Jan 2020

Molecular Pathology Economics 101: An Overview Of Molecular Diagnostics Coding, Coverage, And Reimbursement A Report Of The Association For Molecular Pathology, A. N. Sireci, J. L. Patel, L. Joseph, M. C. Hiemenz, O. C. Rosca, S. K. Caughron, S. A. Thibault-Sennett, T. L. Burke, D. L. Aisner

Journal Articles

No abstract provided.

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Long-Term Effect Of Intraocular Lens Vs Contact Lens Correction On Visual Acuity After Cataract Surgery During Infancy: A Randomized Clinical Trial, S. R. Lambert, G. Cotsonis, L. Dubois, A. Nizam, S. J. Kruger, E. E. Hartmann, D. R. Weakley, C. Drews-Botsch Jan 2020

Long-Term Effect Of Intraocular Lens Vs Contact Lens Correction On Visual Acuity After Cataract Surgery During Infancy: A Randomized Clinical Trial, S. R. Lambert, G. Cotsonis, L. Dubois, A. Nizam, S. J. Kruger, E. E. Hartmann, D. R. Weakley, C. Drews-Botsch

Journal Articles

© 2020 American Medical Association. All rights reserved. Importance: Although intraocular lenses (IOLs) are often implanted in children, little is known whether primary IOL implantation or aphakia and contact lens correction results in better long-term visual outcomes after unilateral cataract surgery during infancy. Objective: To compare long-term visual outcomes with contact lens vs IOL correction following unilateral cataract surgery during infancy. Design, Setting, and Participants: This multicenter randomized clinical trial enrolled 114 infants with a unilateral congenital cataract who underwent cataract surgery with or without primary IOL implantation between 1 and 6 months of age. Data on long-term visual outcomes …

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Lessons Learned: Using The Caprini Risk Assessment Model To Provide Safe And Efficacious Thromboprophylaxis Following Hip And Knee Arthroplasty, E. S. Krauss, M. A. Cronin, N. Dengler, B. G. Simonson, P. Enker, A. Segal Jan 2020

Lessons Learned: Using The Caprini Risk Assessment Model To Provide Safe And Efficacious Thromboprophylaxis Following Hip And Knee Arthroplasty, E. S. Krauss, M. A. Cronin, N. Dengler, B. G. Simonson, P. Enker, A. Segal

Journal Articles

© The Author(s) 2020. Two of the more common potential complications after arthroplasty are venous thromboembolism (VTE), which includes deep vein thrombosis (DVT) and pulmonary embolus (PE), and excess bleeding. Appropriate chemoprophylaxis choices are essential to prevent some of these adverse events and from exacerbating others. Risk stratification to prescribe safe and effective medications in the prevention of postoperative VTE has shown benefit in this regard. The Department of Orthopaedic Surgery at Syosset Hospital/Northwell Health, which performs over 1200 arthroplasties annually, has validated and is using the 2013 version of the Caprini Risk Assessment Model (RAM) to stratify each patient …

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Autoimmune Inner Ear Disease Patient-Associated 28-Kda Proinflammatory Il-1 Beta Fragment Results From Caspase-7 Mediated Cleavage In Vitro, S. Pathak, A. Vambutas Jan 2020

Autoimmune Inner Ear Disease Patient-Associated 28-Kda Proinflammatory Il-1 Beta Fragment Results From Caspase-7 Mediated Cleavage In Vitro, S. Pathak, A. Vambutas

Journal Articles

No abstract provided.

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An Oxygen-Rich Atmosphere Or Systemic Fluoxetine Extend The Time To Respiratory Arrest In A Rat Model Of Obstructive Apnea, S. Mooney, R. Kollmar, R. Gurevich, J. Tromblee, A. Banerjee, K. Sundaram, J. B. Silverman, M. Stewart Jan 2020

An Oxygen-Rich Atmosphere Or Systemic Fluoxetine Extend The Time To Respiratory Arrest In A Rat Model Of Obstructive Apnea, S. Mooney, R. Kollmar, R. Gurevich, J. Tromblee, A. Banerjee, K. Sundaram, J. B. Silverman, M. Stewart

Journal Articles

© 2019 Elsevier Inc. Audiogenic seizure-prone mice can be protected from seizure-associated death by exposure to an oxygen atmosphere or treatment with selective serotonergic reuptake inhibitors (SSRIs). We have shown previously in a rat model that epileptic seizure activity can spread through brainstem areas to cause sufficient laryngospasm for obstructive apnea and that the period of seizure-associated obstructive apnea can last long enough for respiratory arrest to occur. We hypothesized that both the oxygen-rich atmosphere and SSRIs function by prolonging the time to respiratory arrest, thus ensuring that seizure activity stops before the point of respiratory arrest to allow recovery …

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How Can We Improve Antidepressant Adherence In The Management Of Depression? A Targeted Review And 10 Clinical Recommendations., M. Solmi, A. Miola, G. Croatto, G. Pigato, A. Favaro, M. Fornaro, M. Berk, L. Smith, C. U. Correll, A. F. Carvalho, +2 Additional Authors Jan 2020

How Can We Improve Antidepressant Adherence In The Management Of Depression? A Targeted Review And 10 Clinical Recommendations., M. Solmi, A. Miola, G. Croatto, G. Pigato, A. Favaro, M. Fornaro, M. Berk, L. Smith, C. U. Correll, A. F. Carvalho, +2 Additional Authors

Journal Articles

Adherence to antidepressants is crucial for optimal treatment outcomes when treating depressive disorders. However, poor adherence is common among patients prescribed antidepressants. This targeted review summarizes the main factors associated with poor adherence, interventions that promote antidepressant adherence, pharmacological aspects related to antidepressant adherence, and formulates 10 clinical recommendations to optimize antidepressant adherence. Patient-related factors associated with antidepressant non-adherence include younger age, psychiatric and medical comorbidities, cognitive impairment, and substance use disorders. Prescriber behavior-related factors include neglecting medical and family histories, selecting poorly tolerated antidepressants, or complex antidepressant regimens. Multi-disciplinary interventions targeting both patient and prescriber, aimed at improving antidepressant …

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A Primer On A Comprehensive Genetic Approach To Vascular Anomalies, A. J. Borst, T. A. Nakano, F. Blei, D. M. Adams, J. Duis Jan 2020

A Primer On A Comprehensive Genetic Approach To Vascular Anomalies, A. J. Borst, T. A. Nakano, F. Blei, D. M. Adams, J. Duis

Journal Articles

No abstract provided.

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Hrs/Ehra/Aphrs/Lahrs/Acc/Aha Worldwide Practice Update For Telehealth And Arrhythmia Monitoring During And After A Pandemic., N. Varma, N. F. Marrouche, L. Aguinaga, C. M. Albert, E. Arbelo, J. Choi, M. K. Chung, G. Conte, L. M. Epstein, P. D. Varosy, +13 Additional Authors Jan 2020

Hrs/Ehra/Aphrs/Lahrs/Acc/Aha Worldwide Practice Update For Telehealth And Arrhythmia Monitoring During And After A Pandemic., N. Varma, N. F. Marrouche, L. Aguinaga, C. M. Albert, E. Arbelo, J. Choi, M. K. Chung, G. Conte, L. M. Epstein, P. D. Varosy, +13 Additional Authors

Journal Articles

No abstract provided.

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Hrs/Ehra/Aphrs/Lahrs/Acc/Aha Worldwide Practice Update For Telehealth And Arrhythmia Monitoring During And After A Pandemic., N. Varma, N. F. Marrouche, L. Aguinaga, C. M. Albert, E. Arbelo, J. Choi, M. K. Chung, G. Conte, L. M. Epstein, P. D. Varosy, +13 Additional Authors Jan 2020

Hrs/Ehra/Aphrs/Lahrs/Acc/Aha Worldwide Practice Update For Telehealth And Arrhythmia Monitoring During And After A Pandemic., N. Varma, N. F. Marrouche, L. Aguinaga, C. M. Albert, E. Arbelo, J. Choi, M. K. Chung, G. Conte, L. M. Epstein, P. D. Varosy, +13 Additional Authors

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No abstract provided.

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Reduction In St-Segment Elevation Cardiac Catheterization Laboratory Activations In The United States During Covid-19 Pandemic, S. Garcia, M. S. Albaghdadi, P. M. Meraj, C. Schmidt, R. Garberich, F. A. Jaffer, S. Dixon, J. J. Rade, M. Tannenbaum, T. D. Henry, +2 Additional Authors Jan 2020

Reduction In St-Segment Elevation Cardiac Catheterization Laboratory Activations In The United States During Covid-19 Pandemic, S. Garcia, M. S. Albaghdadi, P. M. Meraj, C. Schmidt, R. Garberich, F. A. Jaffer, S. Dixon, J. J. Rade, M. Tannenbaum, T. D. Henry, +2 Additional Authors

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No abstract provided.

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Inpatient Use Of Mobile Continuous Telemetry For Covid-19 Patients Treated With Hydroxychloroquine And Azithromycin, J. Gabriels, M. Saleh, D. Chang, L. M. Epstein Jan 2020

Inpatient Use Of Mobile Continuous Telemetry For Covid-19 Patients Treated With Hydroxychloroquine And Azithromycin, J. Gabriels, M. Saleh, D. Chang, L. M. Epstein

Journal Articles

No abstract provided.

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Author Correction: Caspase-11 Signaling Enhances Graft-Versus-Host Disease (Nature Communications, (2019), 10, 1, (4044), 10.1038/S41467-019-11895-2), Y. Lu, R. Meng, X. Wang, Y. Xu, Y. Tang, J. Wu, Q. Xue, S. Yu, H. Wang, B. Lu, +6 Additional Authors Jan 2020

Author Correction: Caspase-11 Signaling Enhances Graft-Versus-Host Disease (Nature Communications, (2019), 10, 1, (4044), 10.1038/S41467-019-11895-2), Y. Lu, R. Meng, X. Wang, Y. Xu, Y. Tang, J. Wu, Q. Xue, S. Yu, H. Wang, B. Lu, +6 Additional Authors

Journal Articles

© 2020, The Author(s). In the original version of this Article, the following author affiliations were inadvertently switched. Affiliation of Qingde Wang and Timothy R. Billiar should be: “Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, 15213 USA”. Haichao Wang's affiliation should be: “The Feinstein Institute for Medical Research, Northwell Health, 350 Community Drive, Manhasset, NY11030, USA”. The errors have been corrected in the HTML and PDF versions of this article.

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Interim Guidance For Basic And Advanced Life Support In Adults, Children, And Neonates With Suspected Or Confirmed Covid-19: From The Emergency Cardiovascular Care Committee And Get With The Guidelines®-Resuscitation Adult And Pediatric Task Forces Of The American Heart Association In Collaboration With The American Academy Of Pediatrics, American Association For Respiratory Care, American College Of Emergency Physicians, The Society Of Critical Care Anesthesiologists, And American Society Of Anesthesiologists: Supporting Organizations: American Association Of Critical Care Nurses And National Ems Physicians., D. P. Edelson, C. Sasson, P. S. Chan, D. L. Atkins, K. Aziz, L. B. Becker, R. A. Berg, S. M. Bradley, S. C. Brooks, A. Topjian, +17 Additional Authors Jan 2020

Interim Guidance For Basic And Advanced Life Support In Adults, Children, And Neonates With Suspected Or Confirmed Covid-19: From The Emergency Cardiovascular Care Committee And Get With The Guidelines®-Resuscitation Adult And Pediatric Task Forces Of The American Heart Association In Collaboration With The American Academy Of Pediatrics, American Association For Respiratory Care, American College Of Emergency Physicians, The Society Of Critical Care Anesthesiologists, And American Society Of Anesthesiologists: Supporting Organizations: American Association Of Critical Care Nurses And National Ems Physicians., D. P. Edelson, C. Sasson, P. S. Chan, D. L. Atkins, K. Aziz, L. B. Becker, R. A. Berg, S. M. Bradley, S. C. Brooks, A. Topjian, +17 Additional Authors

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No abstract provided.

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Gut Microbiota-Derived Indole 3-Propionic Acid Protects Against Radiation Toxicity Via Retaining Acyl-Coa-Binding Protein, H. W. Xiao, M. Cui, Y. Li, J. L. Dong, S. Q. Zhang, C. C. Zhu, M. Jiang, T. Zhu, H. C. Wang, S. J. Fan, +1 Additional Author Jan 2020

Gut Microbiota-Derived Indole 3-Propionic Acid Protects Against Radiation Toxicity Via Retaining Acyl-Coa-Binding Protein, H. W. Xiao, M. Cui, Y. Li, J. L. Dong, S. Q. Zhang, C. C. Zhu, M. Jiang, T. Zhu, H. C. Wang, S. J. Fan, +1 Additional Author

Journal Articles

© 2020 The Author(s). Background: We have proved fecal microbiota transplantation (FMT) is an efficacious remedy to mitigate acute radiation syndrome (ARS); however, the mechanisms remain incompletely characterized. Here, we aimed to tease apart the gut microbiota-produced metabolites, underpin the therapeutic effects of FMT to radiation injuries, and elucidate the underlying molecular mechanisms. Results: FMT elevated the level of microbial-derived indole 3-propionic acid (IPA) in fecal pellets from irradiated mice. IPA replenishment via oral route attenuated hematopoietic system and gastrointestinal (GI) tract injuries intertwined with radiation exposure without precipitating tumor growth in male and female mice. Specifically, IPA-treated mice represented …

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Erratum: Assessment Of Physician Well-Being, Part Two: Beyond Burnout (Western Journal Of Emergency Medicine (2019) 20:2 (291-304) Doi: 10.5811/Westjem.2019.1.39666), M. D. Lall, T. J. Gaeta, A. S. Chung, S. A. Chinai, M. Garg, A. Husain, C. Kanter, S. Khandelwal, C. S. Rublee, N. T. Himelfarb, +3 Additional Authors Jan 2020

Erratum: Assessment Of Physician Well-Being, Part Two: Beyond Burnout (Western Journal Of Emergency Medicine (2019) 20:2 (291-304) Doi: 10.5811/Westjem.2019.1.39666), M. D. Lall, T. J. Gaeta, A. S. Chung, S. A. Chinai, M. Garg, A. Husain, C. Kanter, S. Khandelwal, C. S. Rublee, N. T. Himelfarb, +3 Additional Authors

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© 2020 eScholarship. All rights reserved. Part One of this two-article series reviews assessment tools to measure burnout and other negative states. Physician well-being goes beyond merely the absence of burnout. Transient episodes of burnout are to be expected. Measuring burnout alone is shortsighted. Well-being includes being challenged, thriving, and achieving success in various aspects of personal and professional life. In this second part of the series, we identify and describe assessment tools related to wellness, quality of life, resilience, coping skills, and other positive states.

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Ultrasound On The Frontlines Of Covid-19: Report From An International Webinar, R. B. Liu, V. S. Tayal, N. L. Panebianco, Y. Tung-Chen, A. Nagdev, S. Shah, E. Pivetta, P. C. Henwood, M. J. Nelson, C. L. Moore Jan 2020

Ultrasound On The Frontlines Of Covid-19: Report From An International Webinar, R. B. Liu, V. S. Tayal, N. L. Panebianco, Y. Tung-Chen, A. Nagdev, S. Shah, E. Pivetta, P. C. Henwood, M. J. Nelson, C. L. Moore

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No abstract provided.

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Use Of Teledermatology By Dermatology Hospitalists Is Effective In The Diagnosis And Management Of Inpatient Disease., C. K. Gabel, E. Nguyen, R. Karmouta, K. J. Liu, G. Zhou, A. Alloo, R. Arakaki, Y. Balagula, V. R. Sharon, Daniela Kroshinsky, +25 Additional Authors Jan 2020

Use Of Teledermatology By Dermatology Hospitalists Is Effective In The Diagnosis And Management Of Inpatient Disease., C. K. Gabel, E. Nguyen, R. Karmouta, K. J. Liu, G. Zhou, A. Alloo, R. Arakaki, Y. Balagula, V. R. Sharon, Daniela Kroshinsky, +25 Additional Authors

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BACKGROUND:Patient outcomes are improved when dermatologists provide inpatient consults. Inpatient access to dermatologists is limited, illustrating an opportunity to utilize teledermatology. Little is known about the ability of dermatologists to accurately diagnose and manage inpatients using teledermatology, particularly utilizing non-dermatologist generated clinical data. METHODS:This prospective study assessed the ability of teledermatology to diagnose and manage 41 dermatology consults from a large urban tertiary care center utilizing internal medicine referral documentation and photos. Twenty-seven dermatology hospitalists were surveyed. Interrater agreement was assessed by the kappa statistic. RESULTS:There was substantial agreement between in-person and teledermatology assessment of the diagnosis with differential diagnosis …

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Targeting Inflammation Driven By Hmgb1, H. Yang, H. Wang, U. Andersson Jan 2020

Targeting Inflammation Driven By Hmgb1, H. Yang, H. Wang, U. Andersson

Journal Articles

© Copyright © 2020 Yang, Wang and Andersson. High mobility group box 1 (HMGB1) is a highly conserved, nuclear protein present in all cell types. It is a multi-facet protein exerting functions both inside and outside of cells. Extracellular HMGB1 has been extensively studied for its prototypical alarmin functions activating innate immunity, after being actively released from cells or passively released upon cell death. TLR4 and RAGE operate as the main HMGB1 receptors. Disulfide HMGB1 activates the TLR4 complex by binding to MD-2. The binding site is separate from that of LPS and it is now feasible to specifically interrupt …

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The Role Of Type 1 Interferons In Coagulation Induced By Gram-Negative Bacteria, X. Yang, X. Cheng, Y. Tang, X. Qiu, Z. Wang, G. Fu, J. Wu, H. Kang, H. Wang, B. Lu, +4 Additional Authors Jan 2020

The Role Of Type 1 Interferons In Coagulation Induced By Gram-Negative Bacteria, X. Yang, X. Cheng, Y. Tang, X. Qiu, Z. Wang, G. Fu, J. Wu, H. Kang, H. Wang, B. Lu, +4 Additional Authors

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No abstract provided.

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