Medicine and Health Sciences Commons^™

Emergence Of Institutional Antithrombotic Protocols For Coronavirus 2019., Kp Cohoon, G Mahé, Aj Tafur, Ac Spyropoulos

Journal Articles

No abstract provided.

Impact Of The Coronavirus Disease 2019 (Covid-19) Pandemic On Imaging Case Volumes, J J. Naidich, A Boltyenkov, J J. Wang, J Chusid, D Hughes, Pc Sanelli

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No abstract provided.

Incidence Of Arrhythmias And Electrocardiographic Abnormalities In Symptomatic Pediatric Patients With Pcr-Positive Sars-Cov-2 Infection, Including Drug-Induced Changes In The Corrected Qt Interval, S Samuel, Ra Friedman, C Sharma, M Ganigara, E Mitchell, C Schleien, Ad Blaufox

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No abstract provided.

Life Interrupted: On The Front Lines With Covid-19, E Argulian, Jw Weinsaft, Rc Hendel, Vp Garg, J Kim, Lm Phillips, J H. Mieres, A Abidov, R Blankstein, J Narula, +1 Additional Author

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No abstract provided.

Spontaneous Coronavirus Disease 2019 (Covid-19)-Associated Luminal Aortic Thrombus, C Mullan, C Powierza, Pe Miller, A Geirsson, P Vallabhajosyula, R Assi

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No abstract provided.

Telemedicine For Cancer Patients During Covid-19 Pandemic: Between Threats And Opportunities, R Elkaddoum, Fg Haddad, R Eid, Hr Kourie

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No abstract provided.

The Renin–Angiotensin System: An Integrated View Of Lung Disease And Coagulopathy In Covid-19 And Therapeutic Implications, B Diamond

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No abstract provided.

Varying Presentations And Favourable Outcomes Of Covid-19 Infection In Children And Young Adults With Sickle Cell Disease: An Additional Case Series With Comparisons To Published Cases., A Appiah-Kubi, S Acharya, C Fein Levy, A Vlachos, G Ostovar, K Murphy, A Farrell, D Brower, Jm Lipton, B Aygun, +1 Additional Authors

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No abstract provided.

Safety Of Psychotropic Medications In People With Covid-19: Evidence Review And Practical Recommendations, G Ostuzzi, D Papola, C Gastaldon, G Schoretsanitis, F Bertolini, F Amaddeo, A Cuomo, R Emsley, C U. Correll, C Barbui, +12 Additional Authors

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No abstract provided.

When Predictions Are Used To Allocate Scarce Health Care Resources: Three Considerations For Models In The Era Of Covid-19., Dm Kent, Jk Paulus, Rr Sharp, N Hajizadeh

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No abstract provided.

Ventilator Triage Policies During The Covid-19 Pandemic At U.S. Hospitals Associated With Members Of The Association Of Bioethics Program Directors, Ah Matheny Antommaria, Ts Gibb, Al Mcguire, Pr Wolpe, Mk Wynia, Mk Applewhite, A Caplan, Ds Diekema, R Mcleod-Sordjan, Jt Eberl, +5 Additional Authors

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No abstract provided.

Virtual Spine: A Novel, International Teleconferencing Program Developed To Increase The Accessibility Of Spine Education During The Covid-19 Pandemic, Jj Rasouli, Jh Shin, Kd Than, Wn Gibbs, Gr Baum, Aa Baaj

Journal Articles

No abstract provided.

Cell-Bound Complement Activation Products Associate With Lupus Severity In Sle., C. Arriens, R. V. Alexander, S. Narain, A. Saxena, C. E. Collins, D. J. Wallace, E. Massarotti, J. Conklin, R. A. Furie, T. Dervieux, +11 Additional Authors

Journal Articles

OBJECTIVES: To evaluate the association between lupus severity and cell-bound complement activation products (CB-CAPs) or low complement proteins C3 and C4.

METHODS: All subjects (n=495) fulfilled the American College of Rheumatology (ACR) classification criteria for SLE. Abnormal CB-CAPs (erythrocyte-bound C4d or B-lymphocyte-bound C4d levels >99th percentile of healthy) and complement proteins C3 and C4 were determined using flow cytometry and turbidimetry, respectively. Lupus severity was estimated using the Lupus Severity Index (LSI). Statistical analysis consisted of multivariable linear regression and groups comparisons.

RESULTS: Abnormal CB-CAPs were more prevalent than low complement values irrespective of LSI levels (62% vs 38%, respectively, …

Circulating Tnf-Like Protein 1a (Tl1a) Is Elevated Early In Rheumatoid Arthritis And Depends On Tnf, Y. Song, I. A. Choi, F. Meylan, M. K. Demoruelle, T. Farley, A. C. Richard, E. Hawley, J. Botson, P. Gregersen, R. M. Siegel, +19 Additional Authors

Journal Articles

No abstract provided.

Allele-Specific Expression Changes Dynamically During T Cell Activation In Hla And Other Autoimmune Loci, M. Gutierrez-Arcelus, Y. Baglaenko, J. Arora, S. Hannes, Y. Luo, T. Amariuta, N. Teslovich, D. A. Rao, P. K. Gregersen, S. Raychaudhuri, +8 Additional Authors

Journal Articles

© 2020, The Author(s), under exclusive licence to Springer Nature America, Inc. Genetic studies have revealed that autoimmune susceptibility variants are over-represented in memory CD4+ T cell regulatory elements1–3. Understanding how genetic variation affects gene expression in different T cell physiological states is essential for deciphering genetic mechanisms of autoimmunity4,5. Here, we characterized the dynamics of genetic regulatory effects at eight time points during memory CD4+ T cell activation with high-depth RNA-seq in healthy individuals. We discovered widespread, dynamic allele-specific expression across the genome, where the balance of alleles changes over time. These genes were enriched fourfold within autoimmune loci. …

Expression Of Concern: Redox Modification Of Cysteine Residues Regulates The Cytokine Activity Of High Mobility Group Box-1 (Hmgb1) (Molecular Medicine (2012) 18 (250-259) Doi: 10.2119/Molmed.2011.00389), H. Yang, P. Lundbäck, L. Ottosson, H. Erlandsson-Harris, E. Venereau, M. E. Bianchi, Y. Al-Abed, U. Andersson, K. J. Tracey, D. J. Antoine

Journal Articles

© The Author(s). 2020. The Editors-in-Chief would like to alert readers that this article (Yang et al. 2012) is part of an investigation being conducted by the journal following the conclusions of an institutional enquiry at the University of Liverpool with respect to the quantitative mass spectrometrygenerated results regarding acetylated and redox-modified HMGB1. Appropriate editorial action will be taken once the investigation is concluded. Huan Yang, Peter Lundbäck, Lars Ottosson, Helena Erlandsson-Harris, Emilie Venereau, Marco E. Bianchi, Yousef Al-Abed, Ulf Andersson, and Kevin J. Tracey agree to this editorial expression of concern. Daniel J. Antoine has not responded to any …

Challenges And Opportunities With Causal Discovery Algorithms: Application To Alzheimer’S Pathophysiology, X. Shen, S. Ma, P. Vemuri, G. Simon, M. W. Weiner, P. Aisen, R. Petersen, C. R. Jack, P. Davies, V. Shibley, +90 Additional Authors

Journal Articles

© 2020, The Author(s). Causal Structure Discovery (CSD) is the problem of identifying causal relationships from large quantities of data through computational methods. With the limited ability of traditional association-based computational methods to discover causal relationships, CSD methodologies are gaining popularity. The goal of the study was to systematically examine whether (i) CSD methods can discover the known causal relationships from observational clinical data and (ii) to offer guidance to accurately discover known causal relationships. We used Alzheimer’s disease (AD), a complex progressive disease, as a model because the well-established evidence provides a “gold-standard” causal graph for evaluation. We evaluated …

Celebrating 20 Years Of Ighv Mutation Analysis In Cll., N. Chiorazzi, F. K. Stevenson

Journal Articles

The division of CLL into 2 broad subsets with highly significant differences in clinical behavior was reported in 2 landmark papers in Blood in 1999.1,2 The simple analysis of the mutational status of the IGV regions provided both a prognostic indicator and an insight into the cellular origins. Derivation from B cells with very low or no IGV mutations generally leads to a more aggressive disease course than derivation from B cells with higher levels. This finding focused attention on surface Ig (sIg), the major B-cell receptor, and revealed dynamic antigen engagement in vivo as a tumor driver. It has …

Key Role Of Mif-Related Neuroinflammation In Neurodegeneration And Cognitive Impairment In Alzheimer's Disease, E. Nasiri, R. Sankowski, H. Dietrich, A. Oikonomidi, P. T. Huerta, J. Popp, Y. Al-Abed, M. Bacher

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No abstract provided.

A Case Report Of Coronavirus Disease 2019 Presenting With Tremors And Gait Disturbance., S. Klein, F. Davis, A. Berman, S. Koti, J. D'Angelo, N. Kwon

Journal Articles

INTRODUCTION:Neurologic symptoms present as significant complications of coronavirus disease 2019 (COVID-19) infection. This report describes a novel manifestation of tremors triggered by severe acute respiratory syndrome coronavirus 2 infection. CASE PRESENTATION:We describe a case of a 46-year-old man with COVID-19 infection complicated by a bilateral intention tremor and wide-based gait. Although neurological manifestations have been reported related to COVID-19, tremulousness has not yet been described. CONCLUSION:Considering the evolving diversity of neurologic manifestations in this infection, emergency physicians should be vigilant of possible COVID-19 infection in patients presenting with unexplained neurologic symptoms.

A Pediatric Infectious Disease Perspective Of Sars-Cov-2 And Covid-19 In Children., A. L. Shane, A. I. Sato, C. Kao, F. C. Adler-Shohet, S. B. Vora, J. Ery, J. Auletta, S. Nachman, M. K. Kainth, K. Kotloff, +15 Additional Authors

Journal Articles

Understanding the role that children play in the clinical burden and propagation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for novel coronavirus (COVID-19) infections is emerging. While the severe manifestations and acute clinical burden of COVID-19 has largely spared children compared to adults, understanding the epidemiology, clinical presentation, diagnostics, management, and prevention opportunities as well as the social and behavioral impacts on child health is vital. Foremost is clarifying the contribution of asymptomatic and mild infections to transmission within the household and community and the clinical and epidemiologic significance of uncommon severe post-infectious complications. Herein we summarize the …

Acute Kidney Injury In Patients With Covid-19: An Update On The Pathophysiology., H. Izzedine, K. D. Jhaveri

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No abstract provided.

Cardiac Catheterization Laboratory Volume Changes During Covid-19—Findings From A Cardiovascular Fellows Consortium, S. Kadavath, J. Mohan, S. Ashraf, A. Kassier, D. Hawwass, N. Madan, N. Salehi, M. Bernardo, M. C. Kim, M. C. Alraies, +13 Additional Authors

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No abstract provided.

Electroconvulsive Therapy Practice Changes In Older Individuals Due To Covid-19: Expert Consensus Statement, M. I. Lapid, S. Seiner, H. Heintz, A. P. Hermida, L. Nykamp, S. N. Sanghani, M. Mueller, G. Petrides, B. P. Forester

Journal Articles

© 2020 American Association for Geriatric Psychiatry The ubiquitous coronavirus 2019 (COVID-19) pandemic has required healthcare providers across all disciplines to rapidly adapt to public health guidelines to reduce risk while maintaining quality of care. Electroconvulsive therapy (ECT), which involves an aerosol-generating procedure from manual ventilation with a bag mask valve while under anesthesia, has undergone drastic practice changes in order to minimize disruption of treatment in the midst of COVID-19. In this paper, we provide a consensus statement on the clinical practice changes in ECT specific to older adults based on expert group discussions of ECT practitioners across the …

Covid-19 Psychosis: A Potential New Neuropsychiatric Condition Triggered By Novel Coronavirus Infection And The Inflammatory Response?, S. J. Ferrando, L. Klepacz, S. Lynch, M. Tavakkoli, R. Dornbush, R. Baharani, Y. Smolin, A. Bartell

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No abstract provided.

Introduction To The Special Series: Translating Behavioral Medicine Research To Prevent And Control The Spread Of Covid-19., A. M. Delamater, S. M. Miller, D. J. Bowen, M. A. Diefenbach, K. P. Tercyak

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No abstract provided.

Management Of Neonates After Postpartum Discharge And All Children In The Ambulatory Setting During The Coronavirus Disease 2019 (Covid-19) Pandemic, K. L. Harriel, D. Nolt, S. Moore, S. Kressly, H. H. Bernstein

Journal Articles

PURPOSE OF REVIEW: The present coronavirus disease 2019 (COVID-19) pandemic has created additional challenges with an increased number of presumed healthy, full-term newborns being discharged at 24 h after delivery. Short lengths of stay raise the possibility of mother-infant dyads being less ready for discharge, defined as at least one of the three informants (i.e., mother, pediatrician, and obstetrician) believing that either the mother and/or infant should stay longer than the proposed time of discharge. This public health crisis has reduced the number of in-person well child visits, negatively impacting vaccine receipt, and anticipatory guidance. RECENT FINDINGS: Extra precautions should …

Pharmacological Treatment Of Hyperactive Delirium In People With Covid-19: Rethinking Conventional Approaches, G. Ostuzzi, C. Gastaldon, D. Papola, A. Fagiolini, S. Dursun, D. Taylor, C. U. Correll, C. Barbui

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No abstract provided.

Pregnancy And Neonatal Outcomes In Sars-Cov-2 Infection: A Systematic Review., R. S. Chamseddine, F. Wahbeh, F. Chervenak, L. J. Salomon, B. Ahmed, A. Rafii

Journal Articles

With the emergence of SARS-CoV-2 and its rapid spread, concerns regarding its effects on pregnancy outcomes have been growing. We reviewed 245 pregnancies complicated by maternal SARS-CoV-2 infection across 48 studies listed on PubMed and MedRxiv. The most common clinical presentations were fever (55.9%), cough (36.3%), fatigue (11.4%), and dyspnea (12.7%). Only 4.1% of patients developed respiratory distress. Of all patients, 89.0% delivered via cesarean section (n = 201), with a 33.3% rate of gestational complications, a 35.3% rate of preterm delivery, and a concerning 2.5% rate of stillbirth delivery or neonatal death. Among those tested, 6.45% of newborns were …

Response To Thrombotic Microangiopathy: Covid-19 Or Hydroxychloroquine?, R. Wanchoo, M. L. Barilla-Labarca, K. D. Jhaveri

Journal Articles

No abstract provided.