Medicine and Health Sciences Commons^™

A Case Of Blunt Trauma-Induced St-Elevation Myocardial Infarction Sustained During A Prison Brawl., Zachary T Clark, Natalie Thiel, John Perry, Michael R Minckler

Articles, Abstracts, and Reports

Myocardial infarction (MI) is a serious and time-sensitive condition. MIs are typically seen in patients with coronary artery disease (CAD) and are caused by the rupture of an atherosclerotic plaque due to factors contributing to plaque instability. However, this case illustrates that plaque rupture can also be caused by blunt trauma to the chest. Considering MI as a possible result of chest trauma may decrease time from presentation to diagnosis and treatment and, therefore, improve outcomes in similar cases, particularly when patients presents unusually or with very few risk factors for MI.

Mentoring Multi-College Bystander Efficacy Evaluation – An Approach To Growing The Next Generation Of Gender-Based Interpersonal Violence Intervention And Prevention (Vip) Researchers, Ann L. Coker, Danielle Davidov, Heather M. Bush, Emily R. Clear

Obstetrics and Gynecology Faculty Publications

The Centers for Disease Control and Prevention provided funding (U01 CE002668) to evaluate bystander program efficacy to reduce gender-based violence on college campuses (Aim 1) and to create a mentoring network (Aim 2) for young campus-based researchers interested in violence intervention or prevention (VIP). While an evaluation of this mentoring program is ongoing, our purpose here was to document the strategies used to create, implement, and begin evaluation of this national multi-college mentoring network. As each public college was recruited into this evaluation named multi-college Bystander Efficacy Evaluation (mcBEE), each college was invited to nominate a researcher interested in receiving …

Validation And Human Factor Analysis Study Of An Infant Weight Estimation Device., Susan M. Abdel-Rahman, Ian M. Paul, Paula Delmore, Jia-Yuh Chen, Mary Mills, Rachel G. Greenberg, Best Pharmaceuticals For Children Act – Pediatric Trials Network

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Weight is critical for the medical management of infants; however, scales can be unavailable or inaccessible in some practice settings. We recently developed and validated a robust infant weight estimation method based on chest circumference (CC) and head circumference (HC). This study was designed to determine the human factors (HF) experience with, and predictive performance of, an infant weight estimation device that implements this method.

METHODS: Prospective, multi-center, observational, masked study of 486 preterm and term infants (0-90 days) assessed by 15 raters. Raters measured the infant using calibrated scales/measures and masked versions of the device. Raters also evaluated …

Deficient Histone H3 Propionylation By Brpf1-Kat6 Complexes In Neurodevelopmental Disorders And Cancer., Kezhi Yan, Justine Rousseau, Keren Machol, Laura A. Cross, Katherine E. Agre, Cynthia Forster Gibson, Anne Goverde, Kendra Engleman, Hannah Verdin, Elfride De Baere, Lorraine Potocki, Dihong Zhou, Maxime Cadieux-Dion, Gary A. Bellus, Monisa D. Wagner, Rebecca J. Hale, Natacha Esber, Alan F. Riley, Benjamin D. Solomon, Megan T. Cho, Kirsty Mcwalter, Roy Eyal, Meagan K. Hainlen, Bryce A. Mendelsohn, Hillary M. Porter, Brendan C. Lanpher, Andrea M. Lewis, Juliann Savatt, Isabelle Thiffault, Bert Callewaert, Philippe M. Campeau, Xiang-Jiao Yang

Manuscripts, Articles, Book Chapters and Other Papers

Lysine acetyltransferase 6A (KAT6A) and its paralog KAT6B form stoichiometric complexes with bromodomain- and PHD finger-containing protein 1 (BRPF1) for acetylation of histone H3 at lysine 23 (H3K23). We report that these complexes also catalyze H3K23 propionylation in vitro and in vivo. Immunofluorescence microscopy and ATAC-See revealed the association of this modification with active chromatin. Brpf1 deletion obliterates the acylation in mouse embryos and fibroblasts. Moreover, we identify BRPF1 variants in 12 previously unidentified cases of syndromic intellectual disability and demonstrate that these cases and known BRPF1 variants impair H3K23 propionylation. Cardiac anomalies are present in a subset of the …

A Multicenter Case Control Study Of Association Of Vitamin D With Breast Cancer Among Women In Karachi, Pakistan, Uzma Shamsi, Shaista Khan, Syed Iqbal Azam, Aysha Habib, Amir Maqbool, Mohammad Hanif, Tiffany Gill, Romaina Iqbal, David Callen

Community Health Sciences

Background: The prevalence of vitamin D inadequacy and breast cancer are both high among women living in Karachi, Pakistan.
Methods: A matched case control study was conducted in two hospitals of Karachi, Pakistan to evaluate the association of vitamin D (serum 25-hydroxyvitamin D) concentrations, vitamin D supplementation and sun exposure with breast cancer among Pakistani women. A total of 411 newly diagnosed histologically confirmed primary breast cancer cases were enrolled and 784 controls, free of breast and any other cancers, were matched by age (year of birth ± 5 years), residence in the same geographic area and study site. Information …

Edge In Roux-En-Y Gastric Bypass: How Does It Compare To Laparoscopy-Assisted And Balloon Enteroscopy Ercp: A Systematic Review And Meta-Analysis, Banreet Singh Dhindsa, Amaninder Dhaliwal, Babu P. Mohan, Harmeet Singh Mashiana, Mohit Girotra, Gordon Ohning, Ishfaq Bhat, Douglas G. Adler

School of Medicine Faculty Research

Background and study aims Endoscopic ultrasound-directed transgastric ERCP (EDGE) is a new endoscopic procedure to perform ERCP in Roux-en-y gastric bypass (RYGB) patients. The aim of this study was to conduct a systematic review and meta-analysis to evaluate technical success, clinical success and adverse effects of EDGE and compare it to laparoscopic ERCP (LA-ERCP) and balloon ERCP (BE-ERCP). Patients and methods We conducted a comprehensive search of several databases and conference proceedings including PubMed, EMBASE, Google-Scholar, LILACS, SCOPUS, and Web of Science databases to identify studies reporting on EDGE, LA-ERCP, and BE-ERCP. The primary outcome was to evaluate technical and …

Acquisition And Development Of Verb/Predicate Chaining In Hebrew, Ruth Aronson Berman, Lyle Lustigman

Faculty Publications

The study considers development and use of verb/predicate chaining constructions by Hebrew speakers from early childhood to adolescence, based on analysis of authentic conversational and narrative corpora. Three types of constructions are analyzed, ordered hierarchically by degree of cohesivity and obligatoriness of chaining: (1) monoclausal complex predicates (the “extended predicates” of traditional Hebrew grammars); (2) coreferential interclausal predicate chaining; and (3) discursively motivated topic chaining. Relevant typological features of Modern Hebrew are reviewed as accounting for the absence of canonical clause chaining in the language (the paucity of non-finite constructions in everyday usage, absence of an uninflected basic form of …

Retrospective Study Of Fmol Health System Utilization Using Geospatial Information, Deekshith Mandala

LSU Master's Theses

Medicaid Expansion and closing of Emergency Departments (ED) like Earl K. Long, Baton Rouge General Mid-City ED, and Champion Medical Center changed the health care landscape in East Baton Rouge Parish (EBRP). In this research study, a Geographical Information System (GIS) is used to analyze the impact of the expansion of Medicaid and the inauguration of Our Lady of the Lake North Baton Rouge ED (OLOL NBR ED) over the utilization of Franciscan Missionaries of our Lady Health System (FMOLHS) for both emergency and non-emergency health care services. This study is performed across the 58 neighborhoods of EBRP. Overutilization of …

Experimental And Computational Tools For Single Cell Analysis In Cancer Diagnostics, Manibarathi Vaithiyanathan

LSU Doctoral Dissertations

Substantial evidence shows that cellular heterogeneity commonly exists within an isogenic or clonal population. Whether in isolation or caused through a combination of the above events, cellular heterogeneity can dramatically influence cellular decision making and cell fate, however, this can be masked by the average response from a population. One approach to solve this issue is to analyze a population at the individual cell level. The goal of this work is to develop high-throughput experimental and computational platforms to screen and quantify single cancer cells for specific intracellular enzyme activities. An interdisciplinary approach was taken to 1) better understand the …

Experiencing Ipe: A Framework Integrating Ipec Standards In Multi-Disciplinary Education, Norman C. Belleza, Maureen Johnson

Physical Therapy Collection

Course Overview

This workshop creates an immersive experience demonstrating the effectiveness using the IPEC framework with IPE-based activities and shares outcome measures for integration into respective educational curricula. A gap exists in health-science programs regarding the effects of IPE. Novel activities include a multi-disciplinary experience of an escape room, chart review, and simulation vignettes. After the workshop, attendees will have tools to build an IPE framework in their respective programs.

Description of Content

Interprofessional education (IPE) elicits better quality behaviors amongst team players promoting improved patient safety and patient outcomes. However, there is a gap in multi-disciplinary health-science academic and …

Astrocyte Support For Oligodendrocyte Differentiation Can Be Conveyed Via Extracellular Vesicles But Diminishes With Age., Cory M Willis, Alexandra M Nicaise, Ernesto R Bongarzone, Maria Givogri, Cory R Reiter, Olivia Heintz, Evan R Jellison, Pearl A Sutter, Gregg Tehennepe, Guruprasad Ananda, Anthony T Vella, Stephen J Crocker

Faculty Research 2020

The aging brain is associated with significant changes in physiology that alter the tissue microenvironment of the central nervous system (CNS). In the aged CNS, increased demyelination has been associated with astrocyte hypertrophy and aging has been implicated as a basis for these pathological changes. Aging tissues accumulate chronic cellular stress, which can lead to the development of a pro-inflammatory phenotype that can be associated with cellular senescence. Herein, we provide evidence that astrocytes aged in culture develop a spontaneous pro-inflammatory and senescence-like phenotype. We found that extracellular vesicles (EVs) from young astrocyte were sufficient to convey support for oligodendrocyte …

Microrna And Transcription Factor Co-Regulatory Networks And Subtype Classification Of Seminoma And Non-Seminoma In Testicular Germ Cell Tumors., Guimin Qin, Saurav Mallik, Ramkrishna Mitra, Aimin Li, Peilin Jia, Christine M. Eischen, Zhongming Zhao

Department of Cancer Biology Faculty Papers

Recent studies have revealed that feed-forward loops (FFLs) as regulatory motifs have synergistic roles in cellular systems and their disruption may cause diseases including cancer. FFLs may include two regulators such as transcription factors (TFs) and microRNAs (miRNAs). In this study, we extensively investigated TF and miRNA regulation pairs, their FFLs, and TF-miRNA mediated regulatory networks in two major types of testicular germ cell tumors (TGCT): seminoma (SE) and non-seminoma (NSE). Specifically, we identified differentially expressed mRNA genes and miRNAs in 103 tumors using the transcriptomic data from The Cancer Genome Atlas. Next, we determined significantly correlated TF-gene/miRNA and miRNA-gene/TF …

Micom: Metagenome-Scale Modeling To Infer Metabolic Interactions In The Gut Microbiota., Christian Diener, Sean M Gibbons, Osbaldo Resendis-Antonio

Articles, Abstracts, and Reports

Compositional changes in the gut microbiota have been associated with a variety of medical conditions such as obesity, Crohn's disease, and diabetes. However, connecting microbial community composition to ecosystem function remains a challenge. Here, we introduce MICOM, a customizable metabolic model of the human gut microbiome. By using a heuristic optimization approach based on L2 regularization, we were able to obtain a unique set of realistic growth rates that corresponded well with observed replication rates. We integrated adjustable dietary and taxon abundance constraints to generate personalized metabolic models for individual metagenomic samples. We applied MICOM to a balanced cohort of …

Non-Invasive Mri Quantification Of Cerebrospinal Fluid Dynamics In Amyotrophic Lateral Sclerosis Patients., Lucas R Sass, Mohammadreza Khani, Jacob Romm, Marianne Schmid Daners, Kyle Mccain, Tavara Freeman, Gregory T Carter, Douglas L Weeks, Brian Petersen, Jason Aldred, Dena Wingett, Bryn A Martin

Articles, Abstracts, and Reports

BACKGROUND: Developing novel therapeutic agents to treat amyotrophic lateral sclerosis (ALS) has been difficult due to multifactorial pathophysiologic processes at work. Intrathecal drug administration shows promise due to close proximity of cerebrospinal fluid (CSF) to affected tissues. Development of effective intrathecal pharmaceuticals will rely on accurate models of how drugs are dispersed in the CSF. Therefore, a method to quantify these dynamics and a characterization of differences across disease states is needed.

METHODS: Complete intrathecal 3D CSF geometry and CSF flow velocities at six axial locations in the spinal canal were collected by T2-weighted and phase-contrast MRI, respectively. Scans were …

Effects Of Range Of Motion On Muscle Development During Resistance Training Interventions: A Systematic Review, Brad J. Schoenfeld, Jozo Grgic

Publications and Research

The purpose of this study was to systematically review the literature as to the effects of performing exercise with a full versus partial range of motion (ROM) during dynamic, longitudinal resistance training (RT) programs on changes in muscle hypertrophy. Based on the available literature, we aimed to draw evidence-based recommendations for RT prescription. Six studies were identified as meeting inclusion criteria: four of these studies involved RT for the lower limbs while the other two focused on the upper extremities. The total combined sample of the studies was n = 135, which comprised 127 men and 8 women. The methodological …

Prenatal Care For Undocumented Immigrants: Implications For Policy, Practice, And Ethics, Rachel Fabi

Population Health Research Brief Series

Nearly 250,000 babies are born each year to undocumented immigrant parents in the U.S. These babies are U.S. citizens, but undocumented immigrants are ineligible for most public insurance, making it difficult for them to access prenatal care. This research brief describes restrictive policies related to prenatal care for undocumented immigrants and discusses how these policies affect health care providers and the care they are able to offer pregnant immigrant women.

Prenatal Diagnosis Of Absent Right Superior Vena Cava In Referrals For Fetal Echocardiography, Ruben J. Acherman, William N. Evans, Humberto Restrepo

School of Medicine Faculty Research

A persistent LSVC with an absent right superior vena cava (RSVC) is unusual, encountered in about 10% of patients with persistent LSVC. We present 14 patients with a prenatal diagnosis of single LSVC and situs solitus, including prenatal findings and information on medium-term follow-up. We identified patients with situs solitus and a persistent LSVC born between March 2004 and March 2020, which had been diagnosed prenatally between December 2003 and November 2019. From this cohort, we identified those with absent RSVC. In the population of women undergoing fetal echocardiography, the prevalence of persistent LSVC in situs solitus was 0.43% (84/19,712). …

Implications Of C1q/Tnf-Related Protein Superfamily In Patients With Coronary Artery Disease., Yanwei Zhang, Caihong Liu, Jing Liu, Rui Guo, Zheyi Yan, Wenxia Liu, Wayne Bond Lau, Xiangying Jiao, Jimin Cao, Kun Xu, Yongping Jia, Xin-Liang Ma, Yajing Wang

Department of Emergency Medicine Faculty Papers

The C1q complement/TNF-related protein superfamily (CTRPs) displays differential effects on the regulation of metabolic homeostasis, governing cardiovascular function. However, whether and how they may serve as predictor/pro-diagnosis factors for assessing the risks of coronary artery disease (CAD) remains controversial. Therefore, we performed a clinical study to elaborate on the implication of CTRPs (CTRP1, CTRP5, CTRP7, and CTRP15) in CAD. CTRP1 were significantly increased, whereas CTRP7 and CTRP15 levels were decreased in CAD patients compared to the non-CAD group. Significant differences in CTRP1 levels were discovered between the single- and triple-vascular-vessel lesion groups. ROC analysis revealed that CTRP7 and CTRP15 may …

Osteopathy In Kansas City: Two New Schools Are Founded, Robyn Oro

Notes from the Archives

No abstract provided.

Spirituality And Prayer On Teacher Stress And Burnout In An Italian Cohort: A Pilot, Before-After Controlled Study, Francesco Chirico, Manoj Sharma, Salvatore Zaffina, Nicola Magnavita

Environmental & Global Health Faculty Research

Introduction: Teaching is a stressful profession that exposes workers to the risk of burnout. Techniques involving higher mental functions, such as transcendental meditation and prayer, have been used in stress and burnout prevention programs. In this study, we report the results of an experience conducted in a group of teachers of a religious institute, in which prayer was used as a technique to prevent burnout. Methods: Fifty teachers and support staff employed at a Catholic school of a Congregation of nuns volunteered for this study. They were randomized into two groups: prayer treatment (n = 25) or control group (n …

Podcasting In Medicine: A Review Of The Current Content By Specialty., Andrew Little, Zach Hampton, Tanner Gronowski, Cameron Meyer, Andrew Kalnow

Medical Education Articles

Background Podcasts and their use in medical education is growing and becoming more popular, all while not knowing what podcasts are available for each specialty. Objectives To ascertain the number of podcasts available by specialty and collect basic characteristics of each podcast.  Methods This was a Google-based, investigational study of medical podcasts by specialty undertaken by all authors from January to June 2019. Search terms included "podcasts in ____", where various specialties were inserted to identify current podcasts. Results Over the course of a six month period, 19 specialties were investigated for podcasting content. Emergency medicine, internal medicine, and pediatrics …

Week Of January 21, 2020, New York Medical College

InTouch

• Class of 2020 Commencement Set for May 19
• Prominent Gastroenterologist to Address 24th Medical Student Research Forum
• STAR Alum is in Top 300 Scholars in the Regeneron Science Talent Search 2020

Starting Simulation For New Residency Programs, Steve Warrington

Emergency Medicine

Objectives

1. Identify 3 barriers and methods to overcome them when implementing simulation in new graduate medical education programs.
2. Discuss pearls and pitfalls to use when implementing a new simulation program at an institution.

Personal Music Listening For Regulating Emotions: A Survey Study, Katie A. Bautch

Pacific Journal of Health

This is a survey study examining the ways in which people use personal music listening as a tool for regulating emotions. It included responses from 109 participants, who answered 16 line items regarding the ways in which they use music to affect their emotions, as well as 7 questions regarding demographic information. Analysis was conducted on line items, and also after grouping into separate functions of music. Results indicated that the most common way people use music is soothing/coping with emotions. The second most commonly used was changing emotions/alternate engagement, followed by mindfulness/matching emotions, and expressing emotion/problem solving. Line items …

Educational Model Integrating Ipec Collaborative Practice Competencies Across Multiple Disciplines, Norman C. Belleza, Maureen Johnson

Physical Therapy Collection

Purpose

The purpose of this project was to design an educational model that integrates the Interprofessional Education Collaborative (IPEC) Collaborative Practice Competency Domains into the curriculum across multiple disciplines. A faculty team from physical therapy (PT), occupational therapy (OT), medicine, and physician’s assistant (PA) programs, collaborated to create an introductory interprofessional education (IPE) framework and course module series. Currently, there are limited studies in rehabilitation education programs demonstrating the effectiveness of IPE-based activities on student outcomes. The proposed framework employs a series of novel educational activities including a multi-disciplinary escape room and scavenger hunt experience, chart review, and interprofessional (IP) …

Prioritization And Management Recommendations Of Pediatric Urology Conditions During The Covid-19 Pandemic, Daniel T. Keefe, Mandy Rickard, Peter Anderson, Darius Bagli, Anne Sophie Blais, Stéphane Bolduc, Luis H. Braga, Natasha Brownrigg, Michael Chua, Sumit Dave, Joana Dos Santos, Luis Guerra, Allen H. Hayashi, Mélise A. Keays, Soojin Kim, Martin A. Koyle, Linda C. Lee, Armando J. Lorenzo, Dawn Maclellan, Landan Macdonald, Andrew E. Macneily, Peter D. Metcalfe, Katherine Moore, Rodrigo L.P. Romao, Peter Z.T. Wang

Paediatrics Publications

No abstract provided.

What's Happening: January 20, 2020, Maine Medical Center

What's Happening

No abstract provided.

Neurodevelopment Outcome Of Neonates Treated With Intraventricular Colistin For Ventriculitis Caused By Multiple Drug-Resistant Pathogens-A Case Series, Kashif Hussain, Muhammad Sohail Salat, Gul Ambreen, Javaid Iqbal

Department of Biological & Biomedical Sciences

Background: Multiple-drug-resistant Gram-negative bacteria (MDR-GNB)-associated neonatal ventriculitis is a life-threatening complication that needs timely diagnosis and effective treatment with broad-spectrum antimicrobials in critical-care settings. Inadequate penetration of antibiotics through the blood-brain barrier also demands an intraventricular (IVT) route of administration. This study reports mortality and neurodevelopmental sequelae of neonates till 18 months of age, who received IVT-colistin for treating MDR-GNB associated ventriculitis.
Methods: In a case series of seven neonates with ventriculitis due to MDR-GNB at NICU of Aga Khan University Hospital, Pakistan, between June 2015 and 2018, we reviewed IVT-colistin therapy in critically ill neonates. Treatment outcomes were assessed …

Ada News - 01/20/2020, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Review Of Alterations In Perlecan-Associated Vascular Risk Factors In Dementia, Amanda L. Trout, Ibolya Rutkai, Ifechukwude J. Biose, Gregory J. Bix

Neurology Faculty Publications

Perlecan is a heparan sulfate proteoglycan protein in the extracellular matrix that structurally and biochemically supports the cerebrovasculature by dynamically responding to changes in cerebral blood flow. These changes in perlecan expression seem to be contradictory, ranging from neuroprotective and angiogenic to thrombotic and linked to lipid retention. This review investigates perlecan's influence on risk factors such as diabetes, hypertension, and amyloid that effect Vascular contributions to Cognitive Impairment and Dementia (VCID). VCID, a comorbidity with diverse etiology in sporadic Alzheimer's disease (AD), is thought to be a major factor that drives the overall clinical burden of dementia. Accordingly, changes …