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Rare Disease Week - Cooper Library Display, Jenessa Mcelfresh, Laura Stanley

Presentations

The Rare Disease Week book display in Cooper Library aims to highlight the history, stories, and impact of rare diseases. This display seeks to demonstrate the many types of rare diseases in the world, the foundational research texts behind disease identification and epidemiology, and the ways that communities can help support individuals living with a rare disease.

Delay Between Onset Of Indication And Definitive Surgery For Tracheal Trauma, Mohammad Bin Pervez, Hassan Mushtaq, Shahmir Chauhan, Ali Aahil Noorali, Yasir Bilal Khan, Muhammad Saad Yousuf, Saulat Fatimi

Section of Cardiothoracic Surgery

Tracheal stenosis is rare but a recognized complication after traumatic injury or prolonged intubation. We assessed the time lag between onset of indication for tracheal reconstruction surgery following trauma and actual surgical intervention. We reviewed our operative records for all patients undergoing tracheal reconstruction over the past 10 years. Files were reviewed retrospectively to collect all the relevant data. Surgically all patients were operated via cervical approach. Series 12 cases were identified with an equal split between external trauma and iatrogenic tracheal trauma from prolonged intubation. On, an average patients presented 185 days after initial indication of surgery however there …

Interview With Dr. Geoffrey Krampitz, Colin Yost

Gibbon Surgical Review

Geoffrey Krampitz, MD, PhD is a hepatopancreaticobiliary surgeon with an extensive background in surgical oncology, stem cell science, and cancer immunotherapy research who recently joined the faculty here at Thomas Jefferson University as an Assistant Professor of Surgery. After earning his BSE in biomedical engineering at Johns Hopkins University and before starting medical training, Dr. Krampitz worked in consulting in the San Francisco Bay Area and eventually helped launch two internet startup companies in Silicon Valley. He then went to UC San Francisco for his Master’s degree, where he investigated the role of HIF1-alpha in stem cell differentiation. Dr. Krampitz …

Primum Non Nocere: Surgeons And The Politics Of Firearm Trauma, Kaushal Desai

Gibbon Surgical Review

The crisis of firearm violence in America continues to worsen and the call to action cannot be ignored. If we are to make a real impact, we must be just as skilled policy makers as proceduralists. We must wield the pen as well as we wield the scalpel. All the clinical knowledge and surgical skills in the world will make no difference if we do not reduce the number of firearm injuries. The skillset we need is policy analysis and lobbying, which can only be developed through political activism and engagement, not more practice questions and Online MedEd.

General Surgery 101: Nissen Fundoplication, Kelley Yuan, Tyler Bauer

Gibbon Surgical Review

The first time that medical students enter the OR can be a jarring experience. Successfully maintaining sterility is hard enough, but remembering relevant patient history, answering “pimp” questions, and performing basic suturing skills can make the third year medical student experience difficult. In this article we describe a common surgery performed by both general and thoracic surgeons with a specific focus on “medical student level” understanding. This piece is the product of a collaboration between an MS1 and MS4, both of whom are interested in a career in surgery. We hope you find it helpful!

Interview With Dr. Dawn Salvatore, Preeyal Patel

Gibbon Surgical Review

A medical student’s path to surgery is notoriously long and arduous. Traditionally, students who are interested in the field begin to prepare their qualifications from day one, especially given the competitive nature of acceptance into surgical programs. For students who develop an interest in surgery during their later years of medical school, it can be a daunting task to pursue a track in which they already feel behind. Often times, these students are discouraged from applying to surgical residencies, worrying that their non-traditional path may hinder their success. However, Dr. Dawn Salvatore can reassure students that a non-traditional path to …

The Utility Of Surgical Simulation In Student Education, Jared Raikin

Gibbon Surgical Review

The use of simulation in the field of surgery has become a heavily researched topic over the last few decades, but it is by no means a new concept. The first recorded use of surgical simulation dates back 2,500 years with evidence of nasal models for flap reconstruction made of leaf and clay.1 But simulation as we know it today did not take shape until the 1980s with the invention of the Comprehensive Anesthesia Simulation Environment (CASE) mannequins. The use of nonorganic simulation tools revolutionized the field and continues to play a large role in medical education. These modalities have …

Bedside To Bench: Basic Science Research During General Surgery Residency, Signe Caksa

Gibbon Surgical Review

Clinical, basic science, and quality improvement research is becoming increasingly integrated into general surgery residency programs, providing aspiring surgeons with an avenue to engage with academia and improve patient care early on in their careers. For example, as an essential part of their training, general surgery residents at Thomas Jefferson University Hospital (TJUH) complete one to two years of research, usually between their PGY3 and PGY4 years. The goal of this protected research time is for residents to gain hands-on surgical research skills and work on translational research projects that correlate with clinical cases, while also becoming more competitive for …

Longevity In Surgery: A Conversation With Two Temple Surgeons About How They Continually Find Joy In Their Careers, Kelsey Muir

Gibbon Surgical Review

Both Dr. Daly and Dr. Pontari describe the stress and pressure that comes with a long career in patient care, however intertwined with the stress is their overwhelming gratitude and joy for surgery. Maintaining that perspective for medicine and patient care has required two things: community and an outlet. Dr. Daly and Dr. Pontari expressed the need to be able to share their anxieties and struggles with someone to process the stress, the difficulties, and the demands of a surgical career.

Surgery Myths And Facts, Heli Patel

Gibbon Surgical Review

Throughout social media, television shows, movies, and “public perception”, surgical residents and attendings are often stereotyped into a personality that is most often incorrect. Unless you are a surgeon, it is often hard to understand what exactly the life entails. Add in some Hollywood drama and social media, and what you get is a wildly disproportionate picture of what surgeons’ personalities are like. As a medical student, it is often difficult to separate fact from fiction, so here are some of the most common myths debunked.

John H. Gibbon, Jr., Md

Gibbon Surgical Review

Dr. John Heysham Gibbon, Jr. graduated from Jefferson Medical College in 1927, and in a brief series of events, he was named Fellow at Massachusetts General Hospital. In 1930, he found himself assisting Dr. Edward Churchill in an emergency pulmonary embolectomy. At that time the procedure was one of desperation, as no patient in the U.S. had survived the removal of blood clots in open-heart surgery. As Dr. Gibbon recorded the patient’s waning vital signs prior to the procedure he thought, “If only we could remove the blood from her body by bypassing her lungs, and oxygenate it, then return …

Gibbon Surgical Review, Volume 3, Issue 1, 2020

Gibbon Surgical Review

Table of Contents

4 - Interview with Dr. Geoffrey Krampitz

8 - Primum Non Nocere: Surgeons and the Politics of Firearm Trauma

10 - General Surgery 101: Nissen Fundoplication

14 - Interview with Dr. Dawn Salvatore

16 - The Utility of Surgical Simulation in Student Education

18 - Bedside to Bench: Basic Science Research During General Surgery Residency

20 - Longevity in Surgery: A Conversation with Two Temple Surgeons About How They Continually Find Joy in Their Careers

22 - Surgery Myths and Facts

24 - Gibbon Surgical Society

25 - John H. Gibbon Jr., MD

26 - Editorial Board …

Circrnas Expressed In Human Peripheral Blood Are Associated With Human Aging Phenotypes, Cellular Senescence And Mouse Lifespan., Shahnaz Haque, Ryan M Ames, Karen Moore, Luke C Pilling, Luanne L. Peters, Stefania Bandinelli, Luigi Ferrucci, Lorna W Harries

Faculty Research 2020

Circular RNAs (circRNAs) are an emerging class of non-coding RNA molecules that are thought to regulate gene expression and human disease. Despite the observation that circRNAs are known to accumulate in older organisms and have been reported in cellular senescence, their role in aging remains relatively unexplored. Here, we have assessed circRNA expression in aging human blood and followed up age-associated circRNA in relation to human aging phenotypes, mammalian longevity as measured by mouse median strain lifespan and cellular senescence in four different primary human cell types. We found that circRNAs circDEF6, circEP300, circFOXO3 and circFNDC3B demonstrate associations with parental …

Non-Traditional And Non-Invasive Approaches In Facial Rejuvenation: A Brief Review, Abigail M. Smith, Taylor Ferris, Vinayak K. Nahar, Manoj Sharma

Walden Faculty and Staff Publications

While injectables, lasers, and surgical interventions have traditionally been used to reverse the changes associated with facial aging, other alternative therapies such as facial acupuncture and facial exercises are now being studied for facial rejuvenation. In this paper, we both summarize the concepts of facial acupuncture and facial exercises, and review seven studies that evaluate the efficacy of these modalities. Data from these studies suggest that both facial acupuncture and facial exercises have the potential to improve the skin laxity, wrinkle length, muscle thickness, and pigmentary changes associated with aging. Patients frequently reported improvement and experienced very few side effects. …

The Impact Of Human Papillomavirus Educational Intervention Study On The Knowledge, Health Beliefs, Health Behaviors And Increasing The Use Of Gardasil In Women Of Color, Charlotte Hurst, Michael Hagensee, Syed Adeel Ahmed, Geornique M. Hayes

The Journal of the Research Association of Minority Professors

Lack of human papillomavirus (HPV) knowledge and cervical cancer awareness are factors contributing to a disproportion in African American (AA) women with cervical cancer. The purpose of this intervention study was to use gender specific and culturally appropriate HPV educational materials to increase HPV knowledge and cervical cancer awareness, to increase health beliefs, and the intent for AA women to use the HPV vaccine. Convenience sampling was used to describe a sample of 98 AA women recruited from an Ambulatory Women’s health clinic between 2015 and 2017. HPV educational videos and pamphlets materials were used to collect baseline and post …

Tumor Slice Culture As A Biologic Surrogate Of Human Cancer., Heidi L Kenerson, Kevin M Sullivan, Yongwoo D Seo, Kathryn M Stadeli, Cigdem Ussakli, Xiaowei Yan, Christopher G Lausted, Venu G Pillarisetty, James O Park, Kimberly J Riehle, Matthew Yeh, Qiang Tian, Raymond S Yeung

Articles, Abstracts, and Reports

Background: The tumor microenvironment (TME) is critical to every aspect of cancer biology. Organotypic tumor slice cultures (TSCs) preserve the original TME and have demonstrated utility in predicting drug sensitivity, but the association between clinicopathologic parameters and

Methods: One hundred and eight fresh tumor specimens from liver resections at a tertiary academic center were procured and precisely cut with a Vibratome to create 250 μm × 6 mm slices. These fixed-dimension TSCs were grown on polytetrafluoroethylene inserts, and their metabolic activities were determined by a colorimetric assay. Correlation between baseline activities and clinicopathologic parameters was assessed. Tissue CEA mRNA expression …

Methylation Signatures In Peripheral Blood Are Associated With Marked Age Acceleration And Disease Progression In Patients With Primary Sclerosing Cholangitis., Michael Trauner, Yevgeniy Gindin, Zhaoshi Jiang, Chuhan Chung, G Mani Subramanian, Robert P Myers, Aliya Gulamhusein, Kris V Kowdley, Cynthia Levy, Zachary Goodman, Michael P Manns, Andrew J Muir, Christopher L Bowlus

Articles, Abstracts, and Reports

Background & Aims: A DNA methylation (DNAm) signature derived from 353 CpG sites (the Horvath clock) has been proposed as an epigenetic measure of chronological and biological age. This epigenetic signature is accelerated in diverse tissue types in various disorders, including non-alcoholic steatohepatitis, and is associated with mortality. Here, we assayed whole blood DNAm to explore age acceleration in patients with primary sclerosing cholangitis (PSC).

Methods: Using the MethylationEPIC BeadChip (850K) array, DNAm signatures in whole blood were analyzed in 36 patients with PSC enrolled in a 96-week trial of simtuzumab (Ishak F0-1, n = 13; F5-6, n = 23). …

Editorial., Jeffrey C Wang, Jens R Chapman, Karsten Wiechert

Articles, Abstracts, and Reports

No abstract provided.

Safety And Immunogenicity Of The Oral, Inactivated, Enterotoxigenic Escherichia Coli Vaccine Etvax In Bangladeshi Children And Infants: A Double-Blind, Randomised, Placebo-Controlled Phase 1/2 Trial, Firdausi Qadri, Marjahan Akhtar, Taufiqur R Bhuiyan, Mohiul I Chowdhury, Tasnuva Ahmed, Tanzeem A Rafique, Arifuzzaman Khan, Sadia I A Rahman, Farhana Khanam, Anna Lundgren, Gudrun Wiklund, Joanna Kaim, Madeleine Löfstrand, Nils Carlin, A Louis Bourgeois, Nicole Maier, Alan Fix, Thomas Wierzba, Richard I Walker, Ann-Mari Svennerholm

Faculty and Staff Publications

Background: Enterotoxigenic Escherichia coli causes diarrhoea, leading to substantial mortality and morbidity in children, but no specific vaccine exists. This trial tested an oral, inactivated, enterotoxigenic E coli vaccine (ETVAX), which has been previously shown to be safe and highly immuongenic in Swedish and Bangladeshi adults. We tested the safety and immunogenicity of ETVAX, consisting of four E coli strains overexpressing the most prevalent colonisation factors (CFA/I, CS3, CS5, and CS6) and a toxoid (LCTBA) administered with or without a double-mutant heat-labile enterotoxin (dmLT) as an adjuvant, in Bangladeshi children.

Methods: We did a randomised, double-blind, placebo-controlled, dose-escalation, age-descending, phase …

Implementation Of A Cardiogenic Shock Protocol And Data Review Process Is Associated With Improved In-Hospital Survival, Adrienne Jones, Renee Swanson, Kateri Spinelli, Joshua Remick, Daniel Westerdahl, Jill M Gelow, David Hotchkin, Jason Wells, Tim Lewis, Robert Kim, Jeff Robinson, Roxanna Barr, Sarah Ramelli, Jacob Abraham

Articles, Abstracts, and Reports

Background: Despite increasing use of mechanical circulatory support devices (MCS), cardiogenic shock (CS) mortality is persistently high, with worsening outcomes in later stages of CS. Delays in diagnosis and practice variation may contribute to in-hospital mortality.

Methods: In June 2018, we devised and implemented a CS protocol at two hospitals from one health system in Portland, OR. The CS protocol was designed to promote early CS recognition, rapid notification of a multi-disciplinary specialty team lead by a heart failure cardiologist, invasive hemodynamic evaluation, and institution of MCS as appropriate. CS was defined by widely accepted clinical and hemodynamic criteria. Patient …

Housing With Services Evaluation Report, Hannah Cohen-Cline, Jannate Ahmed, Kyle Jones, Jb Rinaldi

Articles, Abstracts, and Reports

No abstract provided.

Depresioni Tek Adoleshentët Dhe Menaxhimi I Tij, Fatime Idrizi

Theses and Dissertations

Arsyeja e hulumtimit të kësaj teme studimi është fakti që sot depresioni është bërë një sëmundje mjaft e përhapur në vendin tonë.Pothuajse 80% e njerëzve gjatë gjithë jetës se tyre kalojnë në një periudhë depresioni.Gjatë këtij studimi mund të informohemi për depresionin tek adoloshentët në një spektër më të gjerë,për shkaktarët e tij,kohëzgjatjen,llojet,trajtimin,për rolin e infermiereve në trajtimin e depresionit dhe mjekimin.

Ne si infermier luajmë një rol mjaft të rëndësishëm te këta pacient.Kujdesi ndaj tyre duhet të bëhet në mënyrë të vazhdueshme dhe të palodhshme, që këta pacient të ndihen mirë dhe të sigurtë,të jenë në gjendje të komunikojnë …

Sindroma E Malabsorbimit Te Fëmijët Dhe Kujdesi Infermieror, Rina Trnava

Theses and Dissertations

Malabsorbimi është një sindromë, që i referohet një numri të çrregullimeve në të cilat zorrët e vogla nuk mund të absorbojnë mjaftueshëm lëndë ushqyese dhe lëngje të caktuara. Sëmundjet më të shpeshta janë celiakia (enteropatia e ndjeshme në gluten) dhe fibroza cistike.

Qëllimi i këtij punimi ishte të përcaktohet numri i rasteve të fëmijëve të hospitalizuar me sindromën e malabsorbimit, në periudhën Tetor 2018- Tetor 2019 në klinikën e pediatrisë në QKUK, të përcaktohet numri i rasteve sipas gjinisë, numri i rasteve sipas grupmoshës, numri i rasteve sipas llojit të malabsorbimit, të vlerësohet roli i infermieres në përkujdesjen ndaj këtyre …

Kujdesi Infermieror Te Pacientët Me Shputë Diabetike, Ardona Krivanjeva

Theses and Dissertations

Diabeti melitus është sëmundje metabolike që shkaktohet nga mungesa relative apo

absolute e insulinës në pankreas. Sipas OBSH, diabeti shkakton çdo vit 5% të vdekjeve globale

dhe mendohet se vdekjet nga diabeti në 10 vitet e ardhshme do të rriten me 50%. Diabeti shfaq

edhe komplikime të shumta nëpër organe dhe sisteme organësh; në sy shkakton retinopatinë

diabetike, në veshka shkaktonë nefropatinë diabetike, në tru shkaktonë neuropatinë. Po ashtu në

zemer dhe në enët e gjakut diabeti shkaktonë bllokim të arterieve që furnizojnë zemrën pra infarct të miokardit, hemorragji cerebrale si dhe gangrenë. Ndërlikimi më i madh i diabetit është …

Kujdesi Infermieror Tek Pacientët Me Pneumoni, Arbresha Sylejmani

Theses and Dissertations

Hyrje:Ky punim hulumtues ka të bëj me pneumoninë. Kjo është një sëmundje e mushkërive qe shkakton infeksion të parenkimes së saj. Kjo sëmundje zakonisht i atakon njerëzit me sistem imunitar të dobët, duke mos përjashtuar edhe moshen si faktor kyq në paraqitjen e pnumonisë. Karakterizohet me kollitje,plogeshti, vështirësi në frymarrje poashtu edhe gjendja emocionale e pacientit ështëe brishtë.

Deklarimi i problemit:Pneumonia është problemedhe për profesionin infermieror,të cilët janë në kontakt të vazhdushëm me pacient dhe mundohen që ti shfrytëzojnë të gjitha energjitë për trajtimin e pacientëve me sëmundjen në fjalëdhe ndikimin negativ që ka sëmundja në aspektin holistik. …

Kujdesi Infermieror Tek Të Sëmurët Me Sëmundje Të Refluksit Gastroezofagial, Shkurte Sherifi

Theses and Dissertations

Ky punim është realizuar me qëllim të zgjerimit të njohurive të infermierëve të ardhshëm lidhur me kujdesin infermieror tek të sëmurët me refluks gastroezofagial, ku përmes këtij punimi synohet që të shtjellohet diagnostifikimi, preventiva, zhvillimi dhe mjekimi i Refluksit Gastroezofageal.

Lexuesit mundë të informohen rreth sëmundjes së refluksit gastroezofageal.Ky punim është bërë në kolegjin UBT Programi Infermieri si dhe në bashkpunim me Qendren Klinike Universitare të Kosovës QKUK në Prishtinë,ku të dhënat për numrin e pacientëve janë marrë nga Klinika e Gastroenterologjisë.

Mentori i temës është Prof.Dr.Zaim Gashi.

Punimi përfshinë: 43 faqe, 3 tabela, dhe 7 figura.

Niveli I Njohurive Të Grave Të Trajtuara Në Qkmf-Në E Komunës Së Pejës Lidhur Me Diagnostikimin E Hershëm Të Kancerit Të Gjirit, Vlera Gashi

Theses and Dissertations

Qëllimi i kësaj teme është të japë sado pak ndihmë në ngritjen e nivelit të vetëdijesimit dhe sensibilizimit të popullatës lidhur me sëmundjen e kancerit të gjirit. Duke e vlerësuar nivelin aktual të njohurive tek gjinia femërore, do japim rekomandime për mundësitë e ngritjes së nivelit të njohurive të popullatës tek autoritetet relevante shëndetësore.

Metodat e vlerësimit të gjendjes së gjinjëve mbështeten duke filluar në grumbullimin e të dhënave anamnestike, vetëkzaminimi i gjinjeve, ekzaminimi klinik, ku merr pjesë edhe inspeksioni dhe palpimi, pastaj vazhdohet me metodat imazherike si ekzaminimi me ultratingull i gjinjeve, mamografia, rezonanca magetike (MRI), citologjia aspirative, core …

Qëndrimet Ndaj Abortit Dhe Statusi Social Te Banorët E Ferizajit, Djellza Bajrami

Theses and Dissertations

Aborti është definuar si ndërprerja e shtatzënisë me heqjen ose dëbimin nga mitra të një fetusi ose embrioni. Një abort mund të ndodhë spontanisht, në të cilin rast zakonisht quhet abort ose mund të nxitet qëllimisht. Termi abort më së shpeshti i referohet abortit të shkaktuar nga spontanisht gjatë shtatzënisë. Qëllimi i punimit eshte të vlerësoj qëndrimet dhe statusin social te grave rreth abortit ne Komunen e Ferizajit. Në hulumtim morën pjesë 200 respodent të cilat janë rekrutuar për hulumtim në Komunën e Ferizajit. Sa i përket gjinisë respodentët ishin të ndarë në mënyrë të barabartë (50%) meshkuj dhe (50%) …

Menaxhimi I Dhimbjes Te Të Moshuarit, Ebra Hulaj

Theses and Dissertations

Popullsia e moshuar përfshin segmentin në rritje më të shpejtë të popullsisë në botë. Ndërsa pacientët plaken, incidenca dhe prevalenca e sindromave të caktuara të dhimbjes rritet. Dhimbja mund të raportohet pasi disa pacientë të moshuar gabimisht besojnë se dhimbja është një proces normal i plakjes. Vlerësim gjithëpërfshirës i dhimbjes përfshin një histori të plotë mjekësore dhe ekzaminim fizik, rishikim të sistemeve dhe rezultateve përkatëse laboratorike, studime imazherike dhe teste diagnostikuese. Mjekët e dhimbjes duhet të kenë një gamë të gjerë të të kuptuarit të ndryshimeve farmakologjike dhe fiziologjike që ndodhin në popullatën geriatrike. Shqyrtimi i tanishëm mbi menaxhimin e …

Roli I Infermierës Në Periudhën E Paslindjes - Puerperium, Elonë Grajçevci

Theses and Dissertations

Ardhja e një fëmije në jetën e një çifti sjell një ndryshim thelbësor. Si burri ashtu edhe gruaja ndryshojnë totalisht jetën e tyre të mëparshme dhe e gjejnë veten në rolin e babait ose të nënës papritur. Në muajt e parë të ardhjes së foshnjës në jetë, gjithçka bëhet e vështirë, sidomos në marrëdhënien e tyre në çift për të gjetur harmoninë dhe bashkëpunimin që kishin para se të lindte fëmija. Nëna instinktivisht është ajo që kujdeset më shumë për rritjen e fëmijës, si në planin fizik ashtu edhe në atë emocional, duke krijuar me të një lidhje që i …