Medicine and Health Sciences Commons^™

Everyone Loves Gummi Bears! Removing The Intimidation Factor From Research Data Management With Yummy Fun., Dawn N. Cannon-Rech, Jeffrey M. Mortimore

Georgia International Conference on Information Literacy

How do you get students excited about research data management and attract over 70 participants to a voluntary workshop? How do you get Librarians excited about teaching a research data management workshop to undergraduates? With the promise of Gummi Bears and hands-on fun! During this workshop session, presenters will break down their experience overhauling a faculty workshop into an active learning session to expose students of all experience levels to basic research data management concepts and techniques. Presenters will walk participants through their design process from inception to delivery, highlighting how Gummi Bears lessened students’ intimidation with this complex topic …

Help! No Time For Library Instruction, Not Even A One-Shot, Sheri A. Brown, Dianne M. Fair Ph.D.

Georgia International Conference on Information Literacy

Throughout the semester librarians hear from faculty that there is no time for library instruction. This is especially true for science courses where lab work is required. The Biomedical Sciences program at Florida State College at Jacksonville (FSCJ) is a rigorous, hands-on laboratory-based curriculum with course work covering physics, chemistry, biology, microbiology, molecular biology, and genetics. Students are required to complete IDS4936 – Biomedical Degree Capstone which requires a “multidisciplinary approach of learning science by analyzing social, economic, ethical, scientific, and professional aspects of their chosen topic.” (FSCJ College Catalog 2019-19)

It became apparent students did not have the necessary …

Woodi Health Hub: Promoting Health Information Literacy To Students In The Atlanta University Center, Rosaline Y. Odom

Georgia International Conference on Information Literacy

“Health Literacy is defined as the degree to which individuals have the capacity to obtain, process and understand basic health information and services needed to make appropriate health decisions.” National initiatives call for improved health literacy as a means of addressing ongoing health disparities in the U.S. Low health literacy is linked to a poorer overall health status and higher risk of death among at-risk populations. Vulnerable populations include older adults, immigrant populations, minority populations and low income populations. College years are a time when young adults transition from parental control to independence and face new challenges, stressors and messages …

A Longitudinal, Randomized And Controlled Study Of App-Delivered Mindfulness In The Workplace, Jennifer S. Mascaro, Kathryn Wehrmeyer, Veronica Mahathre, Alana Darcher

Journal of Wellness

Introduction: Workplace mindfulness meditation programs are of great interest for improving employee well-being and job performance, fueled in part by the apparent effectiveness of mindfulness meditation as well as by the recent proliferation of mobile mindfulness applications (apps) that can be incorporated into a workplace setting. It is critical to examine the facilitators and barriers to engaging with app-delivered mindfulness in the workplace to understand how biological, psychological, and socio-demographic variables impact practice time.

Methods: Using a longitudinal and randomized controlled design, we explored facilitators of and barriers to practicing app-delivered mindfulness in the workplace among predominately non-white call center …

We’Re Both Your Librarian: A Course Collaboration Between An Academic Library And A Health Sciences Library, Stephanie Evers Ard

Georgia International Conference on Information Literacy

The University of South Alabama is in the process of merging its academic library and health sciences library, which have previously functioned as essentially separate entities. This ongoing process requires many changes, from budget and staff considerations, to revisiting the roles the librarians play in their respective academic communities. This last concern led to a collaboration between two librarians--the Assistant Director for Strategic Initiatives at the health sciences library and the Social Sciences and Student Engagement Librarian at the academic library--in response to a faculty request for an embedded librarian to support a fully-online graduate nursing class in scholarly writing. …

Lack Of Food Access And Food Consumption Patterns Of Late Midlife Women In Southeast Michigan, Sarah S. Bassiouni, Ebony M. White, Carrie Karvonen-Gutierrez, Sioban D. Harlow

Michigan Journal of Public Health

Background: Food access is a key social determinant of health for older adults at high risk of chronic disease and physical disability.

Methods: This cross-sectional analysis examined correlates of food access and the relationship between food access and food consumption characteristics in a sample of 316 late midlife women from Southeast Michigan in 2015-2016.

Results: Lack of food access, defined as access to self-perceived adequate grocery shopping resources in one’s neighborhood, was reported by 20.9% of women. Women who reported lack of food access were less likely to report making meals at home (p=0.02) and had less frequent consumption of …

Evaluating The Needs Of Cancer Survivors Through Focus Groups And Surveillance Data, Maria George Mph, Taylor Seaton Ms, Debbie Webster Bsn, Rn, Lmsw, Diana Haggerty Ms

Michigan Journal of Public Health

Abstract:

Introduction

As cancer prevention and treatment advances, cancer survival rates continue to increase. The growing population of cancer survivors have unique needs that must be addressed to improve quality of life throughout the cancer-care continuum.

Methods

Using data compiled from the 2015 Michigan Behavioral Risk Factor Survey (MiBRFS), the Cancer Registry, and focus groups, several areas of need amongst cancer survivors were identified.

Results

In focus groups cancer survivors identified the 27 needs that fell into three categories: improving health-related behavior, utilizing health care services, and receiving emotional support. The MiBRFS provided population estimates for 10 of the 27 …

The Burden Of Chronic Health Conditions Among Iraqi Refugees In Michigan, Melissa M. Reznar Phd, Mph, Florence J. Dallo Phd, Mph, Andrew J. Kurecka Mph, Julie J. Ruterbusch Mph, Kendra Schwartz Md, Msph, Madiha Tariq Mph

Michigan Journal of Public Health

The vast majority of refugees in Michigan is from Iraq, and yet the health status of this population is not well defined. The purpose of this study was to describe chronic disease prevalence of Iraqi refugees and examine associations between sociodemographic characteristics and chronic disease. This study reviewed medical charts of 613 Iraqi refugees to examine the association between demographic characteristics and chronic conditions. The dependent variables were body mass index, non-fasting blood glucose, and history of hypertension and diabetes. The independent variables were birth place, age, sex, and smoking history. Men were 3.99 times (95% CI=1.88, 8.48) as likely …

Medicaid Home Visitation And Maternal And Infant Care And Health: A Reassessment Of Program Effectiveness, Cristian Meghea, Zhiying You, Jennifer E. Raffo, Lee Anne Roman

Michigan Journal of Public Health

Introduction: The Maternal Infant Health Program, MIHP, is Michigan's largest home visiting program for Medicaid-eligible pregnant women and infants. Prior quasi-experimental propensity score matched MIHP evaluations were limited by the possibility of selection bias due to the limited available baseline characteristics. The purpose of this study was to assess the effectiveness of MIHP including previously unobserved baseline characteristics to mitigate the possibility of selection bias.

Methods: We analyzed health care and outcomes of mothers and their infants using linked administrative and screening data. All Medicaid pregnant women with a singleton birth in Michigan between 2009 and 2012 who were prenatally …

An Evaluation Of The Michigan State Loan Repayment Program, Dennis Tsilimingras, Wanda Gibson-Scipio, Ramona Benkert, Leon Hudson, Xuefeng Liu, Liying Zhang, Thomas Reed, Tsveti Markova

Michigan Journal of Public Health

No abstract provided.

Preventive Primary Care Screening Patterns After Provider Ehr Adoption For Michigan Medicaid Adults, William D. Corser 9183470, Zhiying You, John Hazewinkel

Michigan Journal of Public Health

Introduction

It remains largely unknown how use of electronic health records (EHR) impacts ordering of preventive/screening services (PSS). These analyses examined the influence of confirmed Medicaid provider EHR adoption on primary care ordering rates of five major PSS. Sample was comprised of 10,149 continuously enrolled Michigan Medicaid adults linked to 6,587 providers.

Methods

The authors obtained complete office-based billing claims data from the Michigan Medicaid Data Warehouse for adults with 29 or more months of continuous state Medicaid coverage. PSS claims data were linked to patients’ Medicaid-assigned providers who either had, or had not, EHR-attested during the 60-month analytic window. …

Corrigendum: Saccade Latency Provides Evidence For Reduced Face Inversion Effects With Higher Autism Traits (Frontiers In Human Neuroscience, (2020), 13, 10.3389/Fnhum.2019.00470), Robin Laycock, Kylie Wood, Andrea Wright, Sheila G. Crewther, Melvyn A. Goodale

Brain and Mind Institute Researchers' Publications

Copyright © 2020 Laycock, Wood, Wright, Crewther and Goodale. In the original article, there was a mistake in the published legend for Figure 2. The results for the high and low Autism Trait (AT) groups were mistakenly interchanged. The correct legend appears below. Figure 2. (A) Average saccade onset times (SOTs) to detect the photograph containing a face or a car in the upright and inverted tasks for high and low Autism Trait (AT) Groups. (B) Face and car inversion effects, calculated as the difference in mean SOTs between upright and inverted tasks for high and low AT Groups. Error …

Molecular Basis For Activation And Biased Signaling At The Thrombin-Activated Gpcr Proteinase Activated Receptor-4 (Par4), Pierre E. Thibeault, Jordan C. Lesarge, D'Arcy Arends, Michaela Fernandes, Peter Chidiac, Peter B. Stathopulos, Leonard G. Luyt, Rithwik Ramachandran

Physiology and Pharmacology Publications

© 2020 Thibeault et al. Proteinase-activated receptor (PAR)-4 is a member of the proteolytically-activated PAR family of G-protein– coupled receptors (GPCR) that represents an important target in the development of anti-platelet therapeutics. PARs are activated by proteolytic cleavage of their receptor N terminus by enzymes such as thrombin, trypsin, and cathepsin-G. This reveals the receptor-activating motif, termed the tethered ligand that binds intramolecularly to the receptor and triggers signaling. However, PARs are also activated by exogenous application of synthetic peptides derived from the tethered-ligand sequence. To better understand the molecular basis for PAR4-dependent signaling, we examined PAR4-signaling responses to a …

Blood Test Shows High Accuracy In Detecting Stage I Non-Small Cell Lung Cancer., Cherylle Goebel, Christopher L Louden, Robert Mckenna, Osita Onugha, Andrew Wachtel, Thomas Long

Articles, Abstracts, and Reports

BACKGROUND: In a previous study (Goebel et. al, Cancer Genomics Proteomics 16:229-244, 2019), we identified 33 biomarkers for an early stage (I-II) Non-Small Cell Lung Cancer (NSCLC) test with 90% accuracy, 80.3% sensitivity, and 95.4% specificity. For the current study, we used a narrowed ensemble of 21 biomarkers while retaining similar accuracy in detecting early stage lung cancer.

METHODS: A multiplex platform, 486 human plasma samples, and 21 biomarkers were used to develop and validate our algorithm which detects early stage NSCLC. The training set consisted of 258 human plasma with 79 Stage I-II NSCLC samples. The 21 biomarkers with …

Empathy As Related To Gender, Age, Race/Ethnicity, Academic Background, And Career Interest: A Nationwide Study Of Osteopathic Medical Students In The United States., Mohammadreza Hojat, Jennifer Desantis, Stephen Shannon, Mark Speicher, Lynn Bragan, Leonard H. Calabrese

Department of Psychiatry and Human Behavior Faculty Papers

CONTEXT: Research on associations between medical student empathy and demographics, academic background, and career interest is limited in number, lacks representative samples, and suffers from single institutional feature. This study was designed to fill the gap by examining associations between empathy in patient care, and gender, age, race/ethnicity, academic background, and career interest in nationwide, multi-institutional samples of medical students in the United States and to provide more definitive answers to the aforementioned associations with more confidence in the internal and external validity of the findings.

METHODS: Four nationwide samples participated in this study (n=10,751). Samples 1, 2, 3, and …

Antagonistic Regulation Of Circadian Output And Synaptic Development By Jetlag And The Dyschronic-Slowpoke Complex, Angelique Lamaze, James E.C. Jepson, Oghenerukevwe Akpoghiran, Kyunghee Koh

Department of Neuroscience Faculty Papers

Circadian output genes act downstream of the clock to promote rhythmic changes in behavior and physiology, yet their molecular and cellular functions are not well understood. Here we characterize an interaction between regulators of circadian entrainment, output, and synaptic development in Drosophila that influences clock-driven anticipatory increases in morning and evening activity. We previously showed the JETLAG (JET) E3 ubiquitin ligase resets the clock upon light exposure, whereas the PDZ protein DYSCHRONIC (DYSC) regulates circadian locomotor output and synaptic development. Surprisingly, we find that JET and DYSC antagonistically regulate synaptic development at the larval neuromuscular junction, and reduced JET activity …

Working Across Disciplines And Library Units To Develop A Suite Of Systematic Review Services For Researchers, Nedelina Tchangalova, Eileen G. Harrington, Stephanie Ritchie, Sarah Over, Jodi Coalter

Collaborative Librarianship

Since their inception in the health sciences field, systematic reviews have expanded into many other subject disciplines. To address this growing need, subject librarians at the University of Maryland Libraries collaborated on a pilot program in three phases to introduce researchers to the process of conducting systematic and scoping reviews. This article describes the development of various collaborative efforts leading to the implementation of a systematic review service based on participant feedback. Assessment and evaluation techniques are shared to encourage further refinement of the systematic review service.

03-02-2020 Hsc Committee Notice, Hsc Committee

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

Distality Of Attentional Focus And Its Role In Postural Balance Control, Christian Kupper, Karen Roemer, Elizabeth Jusko, Karen Zentgraf

All Faculty Scholarship for the College of Education and Professional Studies

The role of attentional focusing in motor tasks has been highlighted frequently. The “internal–external” dimension has emerged, but also the spatial distance between body and attended location. In two experiments, an extended attentional focus paradigm was introduced to investigate distality effects of attentional foci on balance performance. First, the distality of the coordinates of the point of focus was varied between a proximal and distal position on an artificial tool attached to the body. Second, the distance of the displayed effect on the wall was varied between a 2.5 and 5 m condition. Subjects were instructed to focus on controlling …

Letter From The President, Roger Racine

Michigan Journal of Public Health

No abstract provided.

Letter From The Editor, Greg Cline

Michigan Journal of Public Health

No abstract provided.

The Role Of Glial Cell Derived Neurotrophic Factor In Head And Neck Cancer, Hongbin Cao, Qian He, Rie Von Eyben, Joshua Bloomstein, Dhanya K. Nambiar, Vignesh Viswanathan, Sonya Aggarwal, Shirley Kwok, Rachel Liang, Amanda J. Koong, James S. Lewis Jr., Christina Kong, Nan Xiao, Quynh-Thu Le

All Dugoni School of Dentistry Faculty Articles

Glial cell-derived neurotrophic factor (GDNF) is reported to promote the survival of neurons and salivary gland regeneration after radiation damage. This study investigated the effect of GDNF on cell migration, growth, and response to radiation in preclinical models of head and neck squamous cell carcinoma (HNSCC) and correlated GDNF expression to treatment outcomes in HNSCC patients. Our ultimate goal is to determine whether systemic administration of GDNF at high dose is safe for the management of hyposalivation or xerostomia in HNSCC patients. Three HPV-positive and three HPV-negative cell lines were examined for cell migration, growth, and clonogenic survival in vitro …

Extra-Articular Synovial Chondromatosis Of The Ankle: Unusual Case With Radiologic-Pathologic Correlation., Sachin Dheer, Paul E Sullivan, Faith Schick, Homyar Karanjia, Nicholas Taweel, John Abraham, Wei Jiang

Department of Radiology Faculty Papers

Extra-articular synovial chondromatosis is a rare entity in the foot and ankle. We present a case of a 49-year-old female who presented for evaluation of a palpable concern following trauma; which was found to represent synovial chondromatosis. This case demonstrates the multimodality imaging findings, including ultrasound and MRI, with histopathologic correlation.

Oxidant Stress And Renal Function Among Children With Chronic Kidney Disease: A Repeated Measures Study., Melanie H. Jacobson, Mengling Liu, Yinxiang Wu, Susan Furth, Bradley A. Warady, Howard Trachtman, Leonardo Trasande

Manuscripts, Articles, Book Chapters and Other Papers

It is hypothesized that chronic kidney disease (CKD) induces oxidant stress which contributes to the decline in kidney function. However, few studies have incorporated longitudinal designs and no studies have investigated this association among children. Using data from the Chronic Kidney Disease in Children (CKiD) study, we examined longitudinal associations between urinary biomarkers of oxidant stress, 8-OH deoxyguanosine (8-OHdG) and F2-isoprostane, and measures of renal function and blood pressure among children with CKD. Baseline levels of 8-OHdG were positively associated with estimated glomerular filtration rate (eGFR) over time and a log-unit increase in baseline 8-OHdG predicted a 5.68 ml/min/1.73 m2 …

Tailored For Real-World: A Whole Slide Image Classification System Validated On Uncurated Multi-Site Data Emulating The Prospective Pathology Workload., Julianna D. Ianni, Rajath E. Soans, Sivaramakrishnan Sankarapandian, Ramachandra Vikas Chamarthi, Devi Ayyagari, Thomas G. Olsen, Michael J. Bonham, Coleman C. Stavish, Kiran Motaparthi, Clay J. Cockerell, Theresa A. Feeser, Jason B. Lee

Department of Dermatology and Cutaneous Biology Faculty Papers

Standard of care diagnostic procedure for suspected skin cancer is microscopic examination of hematoxylin & eosin stained tissue by a pathologist. Areas of high inter-pathologist discordance and rising biopsy rates necessitate higher efficiency and diagnostic reproducibility. We present and validate a deep learning system which classifies digitized dermatopathology slides into 4 categories. The system is developed using 5,070 images from a single lab, and tested on an uncurated set of 13,537 images from 3 test labs, using whole slide scanners manufactured by 3 different vendors. The system's use of deep-learning-based confidence scoring as a criterion to consider the result as …

Extracellular Vesicles From Human Papilloma Virus-Infected Cervical Cancer Cells Enhance Hiv-1 Replication In Differentiated U1 Cell Line, Sabina Ranjit, Sunitha Kodidela, Namita Sinha, Subhash C. Chauhan, Santosh Kumar

School of Medicine Publications

In the current study, we hypothesized that extracellular vesicles (EVs) secreted from human papilloma virus (HPV)-infected cervical cancer cells exacerbate human immunodeficiency virus (HIV)-1 replication in differentiated U1 cell line through an oxidative stress pathway. To test the hypothesis, we treated an HIV-1-infected macrophage cell line (U1) with HPV-infected Caski cell culture supernatant (CCS). We observed a significant increase in HIV-1 replication, which was associated with an increase in the expression of cytochrome P450 (CYPs 1A1 and 2A6) in the CCS-treated U1 cells. Furthermore, we isolated EVs from CCS (CCS-EVs), which showed the presence of CYPs (1A1, 2A6), superoxide dismutase …

Syllabus For Clinical Exercise Physiology (Kine 4700), Phillip Drouet

Q2S Enhancing Pedagogy

The syllabus has newly developed learning objectives that will prepare students entering the field of clinical exercise physiology. This course will cover the etiology and pathophysiology of many chronic diseases that plague the population. Assessments of chronic diseases include but are not limited to understanding symptomology will also be covered. Due to the limitations in time the most prevalent chronic disease will be covered and students will have to present on a disease that was not presented in class. The practical application portion of this course will take place during a lab section. Here students will have the opportunity to …

A Comparison Of Models For Evaluation And Transfer Of Patients With Suspected Large Vessel Occlusions, Edward Jauch, Parita Bhuva, Alex Schneider, Jason Thurman, Josh Lewis, Kathryn Mccarthy, Debra Philpot, Robin Jones, Albert Yoo, Don Frei

Neurology

Introduction: Mechanisms for the hospital identification of patients with suspected large vessel occlusions (LVO) vary widely based on referring and receiving stroke center resources. We compared processes for identifying patients with suspected LVO who may be candidates for endovascular therapy (EVT) at non-EVT hospitals and the criteria for interfacility transport to Comprehensive Stroke Centers (CSC) for potential EVT. Methods: Data were obtained from 4 CSC which serve distinct geographic regions, ranging from rural to urban environments, over a continuous 12 month period of time beginning year 2018. Patients transferred from all referring hospitals to these facilities were considered regardless of …

Reflections From Five Years Of Research On Fgm/C, Lori S. Ashford, Reshma Naik, Charlotte Greenbaum

Reproductive Health

From 2015 to 2019, the Evidence to End FGM/C research consortium took a fresh approach to examining the longstanding practice of female genital mutilation/cutting (FGM/C). The African-led program developed innovative research methods and uncovered new evidence about the practice and how it is changing—focusing on families and communities, and health and legal systems. This report documents the consortium’s research methods, the key lessons learned, capacity strengthening efforts, enhanced advocacy for research uptake, and recommendations. The research sheds light on key areas for future investments that would ensure that FGM/C policies and programs are informed by rigorous evidence. The recommendations stem …

An Investigation Of Word Learning In The Presence Of Gaze: Evidence From School-Age Children With Typical Development Or Autism Spectrum Disorder, Janet Y. Bang, Aparna S. Nadig

Faculty Research, Scholarly, and Creative Activity

Little is understood about how children attend to and learn from gaze when learning new words, and whether gaze confers any benefits beyond word mapping. We examine whether 6- to 11-year-old typically-developing children (n = 43) and children with Autism Spectrum Disorder (n = 25) attend to and learn with gaze differently from another directional cue, an arrow cue. An eye-tracker recorded children’s attention to videos while they were taught novel words with a gaze cue or an arrow cue. Videos included objects when they were static or when they were manipulated to demonstrate the object’s function. Word learning was …