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Full-Text Articles in Medicine and Health Sciences

The Social Dimensions Of Reproductive Health: Analyzing Disparities In Morocco Through Health Indicators And Social Determinants, Mila Sicorsky Apr 2020

The Social Dimensions Of Reproductive Health: Analyzing Disparities In Morocco Through Health Indicators And Social Determinants, Mila Sicorsky

Independent Study Project (ISP) Collection

This paper explores the social dimensions of reproductive health in Morocco through a look at its health indicators and social determinants. Existing literature discusses reproductive health differences that run on economic, social, and cultural lines. In this paper, I shed light on how best to measure and understand these disparities. The research shows that reproductive health in Morocco is most accurately indicated by maternal mortality rates (MMR), access to prenatal and postnatal visits, and access to adequate family planning. It also finds that location of residence, economic status, and women’s status are key social determinants of reproductive health in Morocco. …


Dominican Nursing Students’ Self-Reported Mastery Of International Nursing Competencies, Wady Ramirez Apr 2020

Dominican Nursing Students’ Self-Reported Mastery Of International Nursing Competencies, Wady Ramirez

Dissertations

The Dominican health care system has many challenges to meet the legal and the population’s health care expectations (La Hoz, 2018; United States Agency for International Development, 2013). The purpose of this study was to evaluate how well Dominican nursing students, who have completed their internship but not yet defended their final career project, assessed themselves against a set of international nursing competencies. In addition, the purpose was to explore any differences in their self-assessments based on whether these students completed their internship at public health care centers or not. Finally, the goal was to determine to what extent do …


An Examination Between Neighborhood Characteristics And Alzheimer’S Disease And Related Dementias And Caregiver Mental Health In South Carolina, Dana Mahmoud Alhasan Apr 2020

An Examination Between Neighborhood Characteristics And Alzheimer’S Disease And Related Dementias And Caregiver Mental Health In South Carolina, Dana Mahmoud Alhasan

Theses and Dissertations

Research has examined the relationship between neighborhood environments and cognitive decline, yet few have investigated the role of neighborhood characteristics specifically on incident Alzheimer’s disease and related dementias (ADRD), on severity of Alzheimer’s disease (AD) including neuropsychiatric symptoms (NPS), and on caregiver mental health including depressive symptoms. This dissertation aimed to 1) ecologically examine the geographic distribution of ADRD and investigate ecologic associations between census-tract neighborhood characteristics and diagnosed ADRD case incidence from 2010-2014 in the South Carolina (SC) Alzheimer’s Disease Registry; 2) estimate the cross-sectional association between neighborhood characteristics and NPS among those with AD in 2010 in SC; …


Comparison Of Comprehensive Health Score In North American Housed Giraffe And Free-Ranging Giraffe From South Africa, Haley Beer Apr 2020

Comparison Of Comprehensive Health Score In North American Housed Giraffe And Free-Ranging Giraffe From South Africa, Haley Beer

Department of Animal Science: Dissertations, Theses, and Student Research

Stress is evident in many animal species and has been correlated to disease prevalence. During stressful events, allostasis is initiated by physiologic systems to maintain or reestablish homeostasis to protect an organism’s viability. Over time, the acclimation to frequent stress causes systematic dysregulation, leading to the phenomena of increased allostatic load. Allostatic load has been assessed in animal species via serum through selection of representative, multi-system biomarker indices. Perception and number of stress events may impact dysregulation severity, yielding allostatic load as a predictive tool. However, the allostatic load methodology poses application limitations to individuals without historical data and those …


Contraceptive Education In South Carolina Women's Jails, Sarah B. Johnson Apr 2020

Contraceptive Education In South Carolina Women's Jails, Sarah B. Johnson

Senior Theses

Women in jail, which is currently a growing population, are at risk of unplanned pregnancy due to their potential exposure to alcohol and drug use, history of living in an abusive environment, and potential practice of prostitution(Clarke et al., 2012; Clarke et al., 2006; Kelly, 2012). The majority of female inmates are between the ages of 17-30, the peak reproductive age, which increases the importance of jails providing education to improve inmates’ reproductive health (Hale et al., 2009). Many females arrested will be released from jail back into society, making jails an opportune place to provide information to improve the …


The Impact Of Financial Incentives On Urban-Rural Disparities In Dental Supply: Evidence From Thailand, Rakchanok Noochpoung Apr 2020

The Impact Of Financial Incentives On Urban-Rural Disparities In Dental Supply: Evidence From Thailand, Rakchanok Noochpoung

Theses and Dissertations

Financial incentive is one of the common strategies used to attract healthcare workers in rural and remote areas. Both high-income and low-income countries extensively use financial strategy to tackle the disparity distribution of healthcare workers. However, most studies were conducted in developed countries and assessed positive incentives programs. Previous studies showed the effectiveness of financial incentives on recruitment and retention of healthcare workers. Current studies show that most of the financial incentives supported for education such as scholarships and loan repayment programs are effective. A few studies assessed the effectiveness of direct payment incentive programs, especially in low-middle income countries. …


The Impact Of Psychosocial, Clinical, And Neighborhood Factors On Inflammatory Outcomes Among African American Women, Malcolm Seth Bevel Apr 2020

The Impact Of Psychosocial, Clinical, And Neighborhood Factors On Inflammatory Outcomes Among African American Women, Malcolm Seth Bevel

Theses and Dissertations

Inflammatory-related chronic diseases are disparagingly prevalent among African Americans in the United States, particularly in the Southeastern region. Access to community gardens shows promise in mitigating chronic disease outcomes, despite multiple barriers to physical activity and diet among underserved populations. We seek to determine if psychosocial or clinical factors mediate the association between the treatment effect of a healthy lifestyle intervention and inflammatory biomarker levels among African American women, respectively. We also seek to analyze the relationship between residing in a food desert/swamp and inflammatory biomarker levels, while gaining a qualitative perspective about community garden access among African American women. …


The Interaction Between Caffeine Consumption, Alcohol Use, And Amount Of Sleep On Bone Health, Haley Davis-Martin Apr 2020

The Interaction Between Caffeine Consumption, Alcohol Use, And Amount Of Sleep On Bone Health, Haley Davis-Martin

Theses and Dissertations

Using cross-sectional data from the 2009-2010 and 2013-2014 NHANES surveys we examined potential interaction between caffeine consumption, alcohol use, and sleep and its relation to bone health, measured using bone mineral density (BMD). The study population consisted of 2,405 individuals at least 40 years old who were not taking any medications or hormones that would affect bone mineral density. Several factors such as smoking status, exercise, dietary intake of calcium, dietary intake of vitamin D, dietary intake of phosphorus, presence of arthritis, age, gender and race were considered in this project. We found a statistically significant negative linear relationships between …


Treatment With Protease Inhibitor And Development Of Diabetes Among Medicare Beneficiaries With Human Immune Virus/Acquired Immune Deficiency Syndrome (Hiv/Aids), Eric Ejike Chinaeke Apr 2020

Treatment With Protease Inhibitor And Development Of Diabetes Among Medicare Beneficiaries With Human Immune Virus/Acquired Immune Deficiency Syndrome (Hiv/Aids), Eric Ejike Chinaeke

Theses and Dissertations

Background: The possibility of an association between the use of protease inhibitors (PI) by HIV/AIDS patients and the occurrence of T2DM mellitus (T2DM) is largely debated. Medicare recipients are disproportionally affected by T2DM. Unfortunately, evidence is unavailable from that particular segment of the population. Clinical management of HIV/AIDS is progressively expanding to include chronic/metabolic complications, which may pose a significant economic burden to both the patients and the Medicare system, which are disproportionally impacted. Objectives: The aims of this project were to (1) examine the association between the use of PIs and the odds of developing T2DM among Medicare beneficiaries …


Effectiveness Of Digital Response Art, Anya Kavanaugh Apr 2020

Effectiveness Of Digital Response Art, Anya Kavanaugh

LMU Theses and Dissertations

This study looks at the effectiveness of digital media to create response art and deepen attunement with adolescent clients as well as develop self-awareness in the therapist. An arts- based qualitative heuristic self-study was used to analyze data gathered over a six-week period. The subject was the researcher/therapist and the data was gathered during the second-year practicum while working with adolescents at a non-public school. Data was gathered through a process of creating two post-session response artworks using video, animation, or digital drawing and a written reflection for each artwork. Nine artworks and eight written reflections were created in total. …


Evaluating The Use Of Narrative Therapy And Art Therapy Among Women Who Have Experienced The Trauma Of Domestic Violence, Cindy G. Bryant Apr 2020

Evaluating The Use Of Narrative Therapy And Art Therapy Among Women Who Have Experienced The Trauma Of Domestic Violence, Cindy G. Bryant

LMU Theses and Dissertations

This research study is aimed at evaluating the artwork created by a woman who has experienced the trauma of domestic violence. A qualitative research approach was used to capture the phenomenological outcomes in the art created during art therapy sessions using the theoretical lens of narrative therapy to analyze the art. For this study the subject was a young woman from Central America who had come into therapy per court mandate to address the issues of domestic violence at a community-based mental health center where the researcher was conducting her second- year practicum. The data (art) was gathered after each …


Cultural Humility Art-Based Training In The Helping Professions, Tara Al-Taan, Silvia Figueroa, Elizabeth Park, Beverly Pascua, Sachi Sosna, Serap Spaltro, Allison Sweeney Apr 2020

Cultural Humility Art-Based Training In The Helping Professions, Tara Al-Taan, Silvia Figueroa, Elizabeth Park, Beverly Pascua, Sachi Sosna, Serap Spaltro, Allison Sweeney

LMU Theses and Dissertations

There has been a lack of training and implementation of cultural humility in the helping professions. Clinician’s awareness of their own biases, assumptions, and cultural identities is critical when working with individuals who each have their own array of cultural identities. The following research examined the efficacy of cultural humility art-based training courses through surveys and examining the art experiential activity that was provided. The purpose of this research was to determine whether cultural humility art-based training would effectively increase mental health practitioners’ comfort, ability, and confidence in addressing culturally sensitive issues in their clinical work. The training focused on …


Hands To Heart: Art Therapy And Voices Of Cancer, Andrea Verano, Reina A. Bicciche Apr 2020

Hands To Heart: Art Therapy And Voices Of Cancer, Andrea Verano, Reina A. Bicciche

LMU Theses and Dissertations

As second-year graduate students from LMU’s Art Therapy program, we are excited to introduce the focus of our Master’s research project, a concept we coined as exhibition as intervention. Our goal is to create a space that brings awareness to the possibilities of exhibition to amplify the voice and increase empathy between artist and viewer. Originally, our vision was to hold the exhibition at Cedars-Sinai to supplement the 2020 Art Therapy Research Symposium. With COVID-19 placing restrictions on public gatherings, the exhibition had to transform from a physical experience to a virtual one. The catalog which began as our secondary …


Hiring Individuals In Addiction Recovery: Characteristics, Levels Of Concern And Willingness, Alicia B. Becton, Sara Werner Juarez, Roy K. Chen Apr 2020

Hiring Individuals In Addiction Recovery: Characteristics, Levels Of Concern And Willingness, Alicia B. Becton, Sara Werner Juarez, Roy K. Chen

School of Rehabilitation Services & Counseling Faculty Publications

Research suggests employment is a key factor in an individual’s recovery and employer’s views have historically limited opportunities for highly marginalized groups. Objectives: This study provides an analysis of views among employers regarding the hiring of individuals in addiction recovery. Methods: A convenience sample of 382 employers affiliated with the chambers of commerce was recruited to participate in this study. The authors used descriptive and inferential statistical methods to analyze data received through an online questionnaire. Results: The results suggest gender influences the views of employers to hire individuals in recovery. Women are more likely to hire individuals in recovery …


History Of The South Dakota Human Services Center 1879-2019: Trials, Trends, And Tragedies To Transformation, Kate L. Katterhagen Apr 2020

History Of The South Dakota Human Services Center 1879-2019: Trials, Trends, And Tragedies To Transformation, Kate L. Katterhagen

Honors Thesis

The history of the South Dakota Human Services Center (HSC), located in Yankton, SD, spans 140 years, from the Dakota Territory days beginning in 1879 to the present. The trials, trends, and tragedies promoting transformation of the state psychiatric hospital are the focus of this thesis, with an emphasis on significant events that shaped the facility. This research examines the challenges and changes in public administration, treatment methods, and psychiatric medical practices. My research was accomplished through identification, retrieval, and review of archived materials, reports, published newspaper articles, and personal accounts. Societal, political, legal, medical, and historical perspectives frame my …


Bilingualism/Multilingualism To Protect Against Cognitive Decline In Alzheimer’S Disease And Other Forms Of Dementia: A Systematic Review, Kirsten L. May Apr 2020

Bilingualism/Multilingualism To Protect Against Cognitive Decline In Alzheimer’S Disease And Other Forms Of Dementia: A Systematic Review, Kirsten L. May

Honors Thesis

Given a growing incidence of Alzheimer’s disease and lack of treatments, prevention is a popular topic in both research literature (Angevaren et al., 2008; Orrell & Sahakian, 1995) and in news articles (Iacono et al., 2009). A cognitive reserve is a skill that improves cognitive functioning in executive controls. Bilingualism is believed to be a practice that increases cognitive reserve, which could delay the onset of Alzheimer’s disease.

The purpose of this project was to analyze the possibility that bilingualism or multilingualism could create a cognitive reserve to delay the onset of Alzheimer’s disease and other dementia-related diseases. This systematic …


Analysis Of Ptv Margins For Vmat Treatment Of Rectal Cancers Utilizing Prone Bellyboard Device., Ben Armbuster Apr 2020

Analysis Of Ptv Margins For Vmat Treatment Of Rectal Cancers Utilizing Prone Bellyboard Device., Ben Armbuster

Masters Projects

Utilization of a bellyboard device reduces small bowel dose for patients receiving radiation therapy for rectal cancer. The reduction of small bowel dose with the bellyboard is even more significant in intensity modulated radiation therapy rectal treatments, as opposed to conventional 3D treatments. However, there is evidence of increased setup variation with prone bellyboard positioning, especially in pitch and roll. The purpose of this study is to determine the margin needed between the clinical target volume and the planning target volume to adequately account for these setup variations when planning volumetric modulated arc therapy rectal cases utilizing the bellyboard device. …


Potential Role Of The Large Protein Titin In The Development Of Heart Failure, Mary M. Prickett Apr 2020

Potential Role Of The Large Protein Titin In The Development Of Heart Failure, Mary M. Prickett

Senior Theses

I will be exploring the impact of the large protein Titin on heart failure with a preserved ejection fraction (HFpEF). It was hypothesized that myocardial Titin plays a significant role in the progression of HFpEF through isoform, N2BA and N2B, changes. It was hypothesized that an increase in the quantity of N2B Titin, less compliant, and a decrease in N2BA Titin, more compliant, will be observed as HF progresses, contributing to an increase in passive stiffness involved in heart contraction. I will cover a detailed report on the role of Titin in HFpEF and propose research methods to explore further.


Analysis Of The Year 2 Questionnaire: Predictions Of Increased Burnout Raise Concern For The Health Of Medical Students, Marco C. Garcia Apr 2020

Analysis Of The Year 2 Questionnaire: Predictions Of Increased Burnout Raise Concern For The Health Of Medical Students, Marco C. Garcia

Senior Theses

Well-being of medical doctors is essential for physicians, the healthcare environment, and treatment of patients. Unfortunately, burnout in this demanding profession has become a prevalent issue. This psychological phenomenon presents as three components: emotional exhaustion, depersonalization, and reduced personal accomplishment. Burnout can diminish professionalism and health care quality, promote medical error, and contribute negatively to physician’s personal lives. Past studies implicate that burnout in physicians is most likely rooted before they even start practicing medicine. Specifically, feelings of burnout start appearing while they are in medical school.

This project explores this proposition via statistical analyzation of the relatively new Year …


Late Preterm Infants Progression Of Adaptive Functioning Skills From Age 8 To 23, Kimberly L'Etoile Apr 2020

Late Preterm Infants Progression Of Adaptive Functioning Skills From Age 8 To 23, Kimberly L'Etoile

Senior Honors Projects

Background: Late preterm infants (LPT) are born 340/7 to 366/7 weeks gestation, comprising 71% of preterm infants in the United States. Despite being of similar size and weight to full term (FT) infants, LPT infants exhibit poorer long-term outcomes. Using data from a longitudinal Rhode Island cohort of former preterm infants, this study investigated adaptive functioning skills of LPT infants as compared to FT infants at 8 and 23 years.

Methods: The sample included 30 LPT infants born 33-36 weeks gestational age (GA) and 40 FT infants. The Child Behavior Checklist (CBCL) at 8 years and Adult Self …


Urinary Epidermal Growth Factor As A Marker Of Disease Progression In Children With Nephrotic Syndrome., Debbie S. Gipson, Howard Trachtman, Anne Waldo, Keisha L. Gibson, Sean Eddy, Katherine M. Dell, Tarak Srivastava, Kevin V. Lemley, Larry A. Greenbaum, Sangeeta Hingorani, Kevin E. Meyers, Frederick J. Kaskel, Kimberly J. Reidy, Christine B. Sethna, Cheryl L. Tran, Chia-Shi Wang, Katherine R. Tuttle, Gia Oh, Alicia M. Neu, Elizabeth Brown, Jen-Jar Lin, Jennifer Lai Yee, Therese M M. Roth, Jonathan P. Troost, Brenda W. Gillespie, Matthew G. Sampson, Matthias Kretzler, Wenjun Ju Apr 2020

Urinary Epidermal Growth Factor As A Marker Of Disease Progression In Children With Nephrotic Syndrome., Debbie S. Gipson, Howard Trachtman, Anne Waldo, Keisha L. Gibson, Sean Eddy, Katherine M. Dell, Tarak Srivastava, Kevin V. Lemley, Larry A. Greenbaum, Sangeeta Hingorani, Kevin E. Meyers, Frederick J. Kaskel, Kimberly J. Reidy, Christine B. Sethna, Cheryl L. Tran, Chia-Shi Wang, Katherine R. Tuttle, Gia Oh, Alicia M. Neu, Elizabeth Brown, Jen-Jar Lin, Jennifer Lai Yee, Therese M M. Roth, Jonathan P. Troost, Brenda W. Gillespie, Matthew G. Sampson, Matthias Kretzler, Wenjun Ju

Manuscripts, Articles, Book Chapters and Other Papers

Introduction: Childhood-onset nephrotic syndrome has a variable clinical course. Improved predictive markers of long-term outcomes in children with nephrotic syndrome are needed. This study tests the association between baseline urinary epidermal growth factor (uEGF) excretion and longitudinal kidney function in children with nephrotic syndrome.

Methods: The study evaluated 191 participants younger than 18 years enrolled in the Nephrotic Syndrome Study Network, including 118 with their first clinically indicated kidney biopsy (68 minimal change disease; 50 focal segmental glomerulosclerosis) and 73 with incident nephrotic syndrome without a biopsy. uEGF was measured at baseline for all participants and normalized by the urine …


Drug Deprescription-Withdrawal Risk, Prevention, And Treatment, Madison K Bangert, Gabriel M Aisenberg Apr 2020

Drug Deprescription-Withdrawal Risk, Prevention, And Treatment, Madison K Bangert, Gabriel M Aisenberg

Faculty, Staff and Student Publications

In most cases, a sudden interruption of most medications has no major consequences. There are well-recognized therapies that, when withheld, can either lead to the reappearance of the symptoms they were controlling or to signs or symptoms of withdrawal. In this article, we present a table including medications that when interrupted can produce withdrawal syndromes, the signs and symptoms of the withdrawal syndrome, the time to onset and resolution of the syndrome, information regarding alternative delivery options for the drug/s when the oral route is not possible, as well as prevention and therapy.


Pitfalls In Quantitative Myocardial Pet Perfusion I: Myocardial Partial Volume Correction, K Lance Gould, Linh Bui, Danai Kitkungvan, Tinsu Pan, Amanda E Roby, Tung T Nguyen, Nils P Johnson Apr 2020

Pitfalls In Quantitative Myocardial Pet Perfusion I: Myocardial Partial Volume Correction, K Lance Gould, Linh Bui, Danai Kitkungvan, Tinsu Pan, Amanda E Roby, Tung T Nguyen, Nils P Johnson

Faculty, Staff and Student Publications

BACKGROUND: PET quantitative myocardial perfusion requires correction for partial volume loss due to one-dimensional LV wall thickness smaller than scanner resolution.

METHODS: We aimed to assess accuracy of risk stratification for death, MI, or revascularization after PET using partial volume corrections derived from two-dimensional ACR and three-dimensional NEMA phantoms for 3987 diagnostic rest-stress perfusion PETs and 187 MACE events. NEMA, ACR, and Tree phantoms were imaged with Rb-82 or F-18 for size-dependent partial volume loss. Perfusion and Coronary Flow Capacity were recalculated using different ACR- and NEMA-derived partial volume corrections compared by Kolmogorov-Smirnov statistics to standard perfusion metrics with established …


Healthy Lifestyles Community Readiness Assessment: Co-Creating Initiatives With Communities And Examining Differences In Sectors And Demographic Characteristics Across Dimensions, Brenna Schmader Apr 2020

Healthy Lifestyles Community Readiness Assessment: Co-Creating Initiatives With Communities And Examining Differences In Sectors And Demographic Characteristics Across Dimensions, Brenna Schmader

Honors Program: Senior Projects (Public)

Nebraska Extension identified a need to better understand community readiness to engage communities and meet their needs. An interdisciplinary team of Extension Educators and Specialists was developed from the Community Vitality Initiative and the Food, Nutrition, and Health team. Six dimensions were identified as contributing factors for healthful communities and were the basis for the Healthy Lifestyles Community Readiness Assessment (HLCRA): Leadership Energy; Issue Awareness; Participation; Inclusivity; Resources; and Entrepreneurial Activities.

The assessment helps determine: a) programming type needed and b) who Extension can connect with in the community to enhance program success. The assessment was piloted by trained staff …


The Effect Of Hay Net Use On Cribbing Horses, Lauren Wesolowski Apr 2020

The Effect Of Hay Net Use On Cribbing Horses, Lauren Wesolowski

Undergraduate Honors Thesis Projects

Cribbing is a stereotypic behavior observed in horses, wherein the animal grasps a solid object with its front incisors and contracts its neck muscles to suck in air through its mouth, resulting in an audible grunt. Stereotypic behaviors such as cribbing are thought to be done in response to stress or insufficient stimulus in an animal’s living environment. Slow feeding hay nets can increase the amount of time horses spend eating daily hay rations. This research aims to use slow feeding hay nets to create a feeding process that is closer to natural grazing behavior and provide more stimulation for …


Temporary Change Of Course Grading Options In Response To Covid-19, Unf Undergraduate Studies Apr 2020

Temporary Change Of Course Grading Options In Response To Covid-19, Unf Undergraduate Studies

UNF COVID-19 Response

Temporary Course grading options in response to Covid-19


Covid-19 Hr Challenge: Lessons From Vigilant Singaporeans, Richard R. Smith Apr 2020

Covid-19 Hr Challenge: Lessons From Vigilant Singaporeans, Richard R. Smith

Research Collection Lee Kong Chian School Of Business

Lessons from Singapore that may benefit global HR business leaders in caring for the health and well-being of the workforce during this challenging time.


It Won’T Be Business As Usual After Covid-19, Arnoud De Meyer Apr 2020

It Won’T Be Business As Usual After Covid-19, Arnoud De Meyer

Research Collection Lee Kong Chian School Of Business

As customer behaviours change, they will reshape business models in the post-coronavirus world.


Establishing A Science-Policy-Society Interface For Biodiversity Conservation And Human Well-Being In The Amazon: The Case Of Madre De Dios, Peru, S. L. Mathez-Stiefel, A. J. Mulanovich, S. Jaquet, S. Bieri, J. Lojas, T. Breu, P. Messerli Apr 2020

Establishing A Science-Policy-Society Interface For Biodiversity Conservation And Human Well-Being In The Amazon: The Case Of Madre De Dios, Peru, S. L. Mathez-Stiefel, A. J. Mulanovich, S. Jaquet, S. Bieri, J. Lojas, T. Breu, P. Messerli

All Peer-Reviewed Publications

This transdisciplinary research aimed to establish the basis for a science-policy-society interface on behalf of environmental conservation and sustainable development in Madre de Dios, Peru by: (1) identifying and characterizing the stakeholders of biodiversity conservation and human wellbeing; (2) analyzing stakeholders' views on major development trends in the region; and (3) initiating a process of stakeholder engagement from academia, government, and civil society. The methods used included field visits, expert interviews, stakeholder mapping, stakeholder surveys, and a participatory multi-stakeholder workshop. Stakeholder mapping revealed 16 categories of key actors grouped among direct land-resource users, indirect land-resource users, the public sector, civil …


Neurochemical Characterization Of Brainstem Pro-Opiomelanocortin Cells, Teodora Georgescu, David Lyons, Barbora Doslikova, Ana Paula Garcia, Oliver Marston, Luke K Burke, Raffaella Chianese, Brian Y H Lam, Giles S H Yeo, Justin J Rochford, Alastair S Garfield, Lora K Heisler Apr 2020

Neurochemical Characterization Of Brainstem Pro-Opiomelanocortin Cells, Teodora Georgescu, David Lyons, Barbora Doslikova, Ana Paula Garcia, Oliver Marston, Luke K Burke, Raffaella Chianese, Brian Y H Lam, Giles S H Yeo, Justin J Rochford, Alastair S Garfield, Lora K Heisler

Faculty, Staff and Student Publications

Genetic research has revealed pro-opiomelanocortin (POMC) to be a fundamental regulator of energy balance and body weight in mammals. Within the brain, POMC is primarily expressed in the arcuate nucleus of the hypothalamus (ARC), while a smaller population exists in the brainstem nucleus of the solitary tract (POMCNTS). We performed a neurochemical characterization of this understudied population of POMC cells using transgenic mice expressing green fluorescent protein (eGFP) under the control of a POMC promoter/enhancer (PomceGFP). Expression of endogenous Pomc mRNA in the nucleus of the solitary tract (NTS) PomceGFP cells was confirmed using fluorescence-activating cell sorting (FACS) followed by …