Medicine and Health Sciences Commons^™

Novel Paclitaxel Nanoparticles For Enhanced Therapeutic Effects In Breast Cancer, Pallabita Chowdhury

Theses and Dissertations (ETD)

Drug delivery to triple negative breast cancer (TNBC) remains a formidable challenge. Given the lack of expressions of estrogen (ER), progesterone (PR) and human epidermal growth factor receptor (HER2), there is no specific prognostic marker for targeting this aggressive cancer. In spite of rapid advancement in breast cancer with agents such as Trastuzumab in HER2 positive, chemotherapy with cytotoxic agents remains the mainstay treatment for TNBC. Although these cytotoxic agents are potent in managing the tumor progression, yet they pose adverse effects on healthy tissues. Paclitaxel (PTX) has been used as a gold standard chemotherapeutic agent for breast, ovarian, pancreatic …

Structure And Stability Of W1/O/W2 Emulsions As Influenced By Wpc And Nacl In Inner Aqueous Phase, Vivek Prakash Wankhede, Prateek Sharma, Shaik Abdul Hussain, Ram Ran Bijoy Singh

Nutrition, Dietetics, and Food Sciences Faculty Publications

Effect of WPC and NaCl in internal aqueous phase (W1) of W1/O/W2 type double emulsions was studied. Pre-emulsion and final emulsion were prepared using microfluidizer and Ultra-Turrax high shear mixer, respectively. The emulsions prepared using salt exhibited uniform droplet size distribution and structural integrity. WPC at 6% and NaCl at 2 or 4% levels demonstrated better sedimentation stability (> 99%) and encapsulation stability (> 95%) during preparation and storage of double emulsions. Samples without added NaCl showed poor emulsion stability and structural integrity. Higher level of WPC i.e. 8% resulted in poor stability and encapsulation efficiency of double emulsions at …

Mental Health Inpatient Hospitalization: What Nursing Can Learn From "Sensory Rooms.", Haley Wilson

Honors Theses

The purpose of this undergraduate thesis is to explore the use of sensory rooms in the psychiatric inpatient care setting. Mental illness is a serious issue, affecting millions each year. In 2018 the Substance Abuse and Mental Health Services Administration (SAMHSA) reported that one in five, or 19.6% of U.S. adults experienced some form of mental illness. Inpatient hospitalization is limited to those individuals posing a risk for serious harm to themselves or others. A census conducted by SAMHSA on April 30th, 2018, indicated 129,115 patients in the U.S. were receiving mental health care treatment in the inpatient setting. An …

Gender And Socioeconomic Disparities In Iatrogenic In-Hospital Torsades De Points, Bradley Reinoehl

Honors Theses

It has been well established for decades that women are at increased risk for torsades de pointes (TdP). Additionally, it has been well documented that patients of lower socioeconomic status (SES) tend to have inferior health outcomes compared to other patient populations. In this study we investigate the incidence of iatrogenic in-hospital TdP among these two demographic groups. Iatrogenic in-hospital TdP is a complex combination of medical issues and including danger from QT prolonging medications. In theory, a combination of identifiable, demographic risk factors coupled with specific clinical settings could be used to identify patients at high risk for iatrogenic …

Evaluation Of Computer Aided Detection Of Tuberculosis On Chest Radiography Among People With Diabetes In Karachi Pakistan, Shifa Salman Habib, Sana Rafiq, Syed Mohammad Asad Zaidi, Rashida Abbas Ferrand, Jacob Creswell, Bram Van Ginneken, Wafa Zehra Jamal, Kiran Sohail Azeemi, Saira Khowaja, Aamir Khan

Community Health Sciences

Pakistan ranks fifth among high tuberculosis (TB) burden countries and also has seventh highest burden for diabetes mellitus (DM). DM increases the risk of developing TB and contributes to adverse TB treatment outcomes hence screening and integrated management for both diseases in high burden countries is suggested. Computer-Aided Detection for TB (CAD4TB) can potentially be used as triage tool in low resource settings to pre-screen individuals for Xpert MTB/RIF testing. The aim of this study was to evaluate the diagnostic accuracy and performance of CAD4TB software in people with diabetes (PWD) enrolled in a TB screening program in Karachi, Pakistan. …

School-Based Interventions To Promote Personal And Environmental Hygiene Practices Among Children In Pakistan: Protocol For A Mixed Methods Study, Nousheen Pradhan, Waliyah Mughis, Tazeen S. Ali, Maleeha Naseem, Rozina Karmaliani Professor

Community Health Sciences

Background: Poor personal hygiene and inadequate sanitation practices among young children leads to communicable diseases. There remains a gap in the holistic assessment of school children's hygiene literacy, practices and effectiveness of school-based hygiene interventions in Pakistan. Therefore, a school-based intervention protocol has been designed to promote personal and environmental hygiene practices for primary school children. Towards improving children's hygiene behaviors, the study will also focus on enhancing mothers' hygiene knowledge and practices.
Methods: Using quasi-experimental design with mixed methods data collection approaches, this study will be conducted in schools located in an urban squatter settlements in Pakistan. To assess …

A Validated Composite Organ And Hematologic Response Model For Early Assessment Of Treatment Outcomes In Light Chain Amyloidosis, Surbhi Sidana, Paolo Milani, Moritz Binder, Marco Basset, Nidhi Tandon, Andrea Foli, Angela Dispenzieri, Morie A Gertz, Suzanne R Hayman, Francis K Buadi, Martha Q Lacy, Prashant Kapoor, Nelson Leung, S Vincent Rajkumar, Giampaolo Merlini, Giovanni Palladini, Shaji K Kumar

Faculty, Staff and Student Publications

Newly diagnosed AL amyloidosis patients were evaluated to develop a model for early assessment of treatment benefit at 6 months, integrating both hematologic (HR) and organ response (OR) assessment (testing cohort, Mayo: n = 473; validation cohort, Pavia: n = 575). Multiple OR were assessed as follows: All OR (AOR): response in all organs, mixed OR (MOR): response in some organs, no OR (NOR)]. AOR rates at 6 months improved with deepening HR; complete response (CR; 38%, 35%), very good partial response (VGPR; 30%, 26%), and partial response (PR; 16%, 21%), respectively. A composite HR/OR (CHOR) model was developed using …

Virtual Visits For Care Of Patients With Heart Failure In The Era Of Covid-19: A Statement From The Heart Failure Society Of America, Eiran Z. Gorodeski

Faculty Scholarship

In response to the COVID-19 pandemic, US federal and state governments have implemented wide-ranging stay-at-home recommendations as a means to reduce spread of infection. As a consequence, many US healthcare systems and practices have curtailed ambulatory clinic visits—pillars of care for patients with heart failure (HF). In this context, synchronous audio/video interactions, also known as virtual visits (VVs), have emerged as an innovative and necessary alternative. This scientific statement outlines the benefits and challenges of VVs, enumerates changes in policy and reimbursement that have increased the feasibility of VVs during the COVID-19 era, describes platforms and models of care for …

Modulating The Rate Of Fibrin Formation And Clot Structure Attenuates Microvascular Thrombosis In Systemic Inflammation, Christian Valladolid, Marina Martinez-Vargas, Nitin Sekhar, Fong Lam, Cameron Brown, Timothy Palzkill, Alexander Tischer, Mathew Auton, K Vinod Vijayan, Rolando E Rumbaut, Trung C Nguyen, Miguel A Cruz

Faculty, Staff and Students Publications

Systemic inflammation can lead to coagulopathy and disseminated intravascular coagulation (DIC). In prior studies, the recombinant A2 domain of human von Willebrand factor (VWF; A2 protein) attenuated DIC and decreased mortality in lipopolysaccharide (LPS)-treated mice. Here, we performed studies to dissect the mechanism by which the A2 protein moderates DIC. We used confocal microscopy to analyze the fibrin clot structure in plasma from healthy humans and endotoxemic mice, turbidity assays to examine fibrin polymerization, and a murine model for LPS-induced DIC and introduced a loss-of-function mutation into the A2 protein for fibrin. The mutation of the residue E1567 located in …

Review Of Evidence Paper Practice And Patient Outcome Improvements Of Prescribing First-Line Antibiotics For Acute Uncomplicated Cystitis, Ira Amayun

DNP Qualifying Manuscripts

Abstract

Background: In 2017, the Centers for Disease Control and Prevention (CDC) published guidelines for treating acute uncomplicated cystitis (AUC) with nitrofurantoin (NTF), sulfamethoxazole-trimethoprim (SMX-TMP), or fosfomycin (FM) as appropriate first-line agents.

Objective: This paper aims to evaluate whether provider adherence to prescribing NTF, SMX-TMP, or FM has improved since the 2017 CDC guidelines were released, and to examine outcomes relative to use of prescribing guidelines in the treatment of AUC in non-pregnant women.

Methods: A literature review was conducted. The Cochrane Risk of Bias Tool was used to assess publication bias. The John Hopkins Research Evidence Appraisal Tool was …

Reducing Pressure Injuries In The Intensive Care Setting: Nursing Knowledge And Best Practices Approach, Michelle Harvey

Doctor of Nursing Practice Projects

Background: For many health care organizations, pressure injury (PI) prevention strategies have become a priority focus to improve patient outcomes and associated costs.

Problem: A rural community hospital located in the Eastern U.S. experienced an increase in hospital acquired pressure injuries (HAPIs), predominantly in the intensive care unit (ICU). In 2018, 17.4% of HAPIs occurred in the ICU.

Approach: Implementation of a Quality Improvement project in an adult ICU, providing education and on-going learning activities to nursing staff, and applying a standardized plan of care “bundle” for prevention interventions.

Outcomes: The approach resulted in improved documentation of flotation of heels, …

Covid-19 In The Rural South: A Perfect Storm Of Disease, Health Access, And Co-Morbidity, Anne Cafer, Meagen Rosenthal

APCRL Policy Briefs

No abstract provided.

Covid-19: Change Of Plans - A Photojournal, Tim Swanson

Reflections, Poetry, Photos, and other Writings

This photo journal was an assignment for one of my classes. From March 20 to April 12 I photographed scenes from my life as it now was due to the Coronavirus, and wrote statements reflecting on the context in which they were taken.

2020-04-13_Michiganoverview_Covidcounts, Michigan Department Of Health & Human Services

Michigan COVID-19 Confirmed Cases by Date of Onset Data

Data was captured from the Cumulative Data link of Michigan's Coronavirus webpage, under the url https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173_99207---,00.html.

The website contained the table Count of Confirmed COVID-19 Cases by Date of Onset , sorted by Michigan Preparedness Region. It also contained 18 charts, including the count of confirmed Covid-19 cases by date of onset in the state overall as well as in each preparedness region,and the normalized rate of Covid-19 cases per 1,000,000 residents in both the state and in each preparedness region.

Medication-Related Osteonecrosis Of The Mandible, Galal Omami

Oral Health Practice Faculty Publications

No abstract provided.

Hypochondria And Interpersonal Relationships, Cynthia Kmety

2020 Awards for Excellence in Student Research and Creative Activity

Interpersonal relationships are important parts of our everyday lives, that can affect how we interact with others and can affect health status. This view on interpersonal relationships is often overlooked, however. This study was conducted with the goal of analyzing how the presence of hypochondria affects interpersonal relationships. It was hypothesized that those who have hypochondria will experience more negative interpersonal relationships. The researcher conducted a study using a survey that was administered to sixty-nine people. Results of the research and survey found that there were strained interpersonal relationship between people who have connections to hypochondria. Further research needs to …

2020-04-13_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

The webpage was obtained from Michigan's Coronavirus Cumulative Data page, under the link Data About Places.
It contains aggregated data, self-reported by hospitals daily to the EM Resource System per MDHHS Director Robert Gordon's Emergency Order.

2020-04-13_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., with COVID-19 results included as of 10 a.m.

Note on cumulative counts: This report is provisional and subject to change. As public health investigations of individual cases continue, there will be corrections to the status and details of referred cases that result in changes to this report.
Note on the deaths: Deaths must be reported by health care providers, medical examiners/coroners, and recorded by local health departments …

2020-04-13_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

A Narrative Review And Content Analysis Of Functional And Quality Of Life Measures Used To Evaluate The Outcome After Tsa: An Icf Linking Application, Ze Lu, Joy C. Macdermid, Peter Rosenbaum

Bone and Joint Institute

© 2020 The Author(s). Background: Total shoulder arthroplasty (TSA) is considered as the standard reconstructive surgery for patients suffering from severe shoulder pain and dysfunction caused by arthrosis. Multiple patient-reported outcome measures (PROMs) have been developed and validated that can be used to evaluate TSA outcomes. When selecting an outcome measure both content and psychometric properties must be considered. Most research to date has focused on psychometric properties. Therefore, the current study aims to summarize what PROMs are being used to assess TSA outcomes, to classify the type of measure (International society for quality of life (ISOQOL) using definitions of …

2020-04-13 A Message From Chancellor Roth, Paul B. Roth

HSC Messages from the Chancellor

No abstract provided.

Dental Therapists Providing Access To Oral Health Care To Children In Florida, Shankisha D. Sizemore

Dental Hygiene ETDs

The state of Florida has proposed the establishment of the dental therapy mid-level provider to alleviate the lack of access to oral health care of the underserved population. Despite the success in other states opposition exists this workforce model. The purpose of this research is to evaluate the attitudes of Florida school-based nurses regarding the development of dental therapists to address the states oral health access issues. A survey queried a random sample of 300 Florida school-based nurses regarding dental therapy and access to oral health care issues among the school age children population. Twenty-three school-based nurses responded (7.8%). Results …

Plyometric Training And Its Effects On The Neuromuscular System, Bradley Andrew Martin

Theses and Dissertations

Plyometric training is commonly employed by athletic trainers, personal trainers, and strength and conditioning coaches, especially for those athletes who require quickness, agility, and high vertical jump performance. It is well documented in its ability to increase these aspects of performance.(12, 14, 16, 20) There are many proposed mechanisms in place which attempt to explain why it is so effective, however, many of the proposed mechanisms are still theoretical. The purpose of this study is to examine some of those proposed mechanisms that drive the success of plyometric training. This project investigates the neurological effects of plyometric training by examining …

Aota Continuing Education: Occupational Therapy’S Role In Addressing Sexuality And Intimacy, Tiffany E. Lee, Jacqueline M. Marquez

OTD Capstone Projects

The purpose of this capstone project was to create a continuing education course for the American Occupational Therapy Association (AOTA) on the topic of OT’s role in addressing sexuality and intimacy. The topic of sexuality and intimacy is often under-addressed by healthcare professionals, despite its importance to clients. According to the Occupational Therapy Practice Framework, engagement in sexual activity is not only an ADL, but can be a key aspect of social participation in the context of familial and peer/ friend roles. Therefore, it is well within OT’s scope of practice to address sexuality and intimacy with clients. However, there …

Association Of Long-Term Consumption Of Repeatedly Heated Mix Vegetable Oils In Different Doses And Hepatic Toxicity Through Fat Accumulation, Gul Ambreen, Afshan Siddiq, Kashif Hussain

Department of Biological & Biomedical Sciences

Background: Hepatic diseases are one of the chief reasons for worldwide morbidity and mortality. The increased incidence in Asian countries is driving researchers to explore preventive ways from nature. It is more practical to go with healthy routine edibles like vegetable oils to avoid environmental and chemical hepatic injuries. With the use of thermally oxidized oils overproduction of reactive oxygen species (ROS) with overwhelmed cellular antioxidants defense system results in oxidative stress, the known cause of cardiovascular diseases (CVDs), cancers and neurodegenerative disorders. Little is investigated about the effect of daily used oxidized cooking oils on hepatic function changes with …

Testing Postural Control With Kinesiology Tape And A Compression Ankle Sleeve In Dancers, Sarah Catherine Unger

Theses and Dissertations

The purpose of this study is to assess if kinesiology tape (KT) and compression sleeves can influence balance and postural control by assessing center of pressure (CoP). This study will also compare the effectiveness of increasing postural control between KT and a compression sleeve. Fifteen female subjects between the ages of 18 and 22 years old volunteered to participate in this study. One subject's data was discarded due to KT disruption. The fourteen remaining subjects were randomly assigned to either the KT, compression sleeve, or control group. Each subject performed a semi-dynamic balance test (modified Airplane Test) on a portable …

Evolutionary Ecology Of Host-Parasite Relationships: Role Of Host Ecology, Phylogeny, And Demographics In Shaping Parasite Evolution, Erika Taylor Gendron

Biology ETDs

Host-parasite systems exist across complex and ecologically heterogeneous landscapes, and may occur across taxonomically and ecologically disparate host species. Under these conditions, mechanisms underlying microevolutionary processes (i.e. gene flow, genetic drift) are not always clear, and may be mediated by numerous co-occurring factors specific to individual hosts. Host traits such as host immunology, demographics, phylogeny and ecology may act in concert to shape host-parasite relationships, and ultimately evolutionary processes. The research described herein used phylogeographic, phylogenomic, and population genetic methods to further understanding of how host traits impact the evolutionary ecology of trematode systems, using avian schistosomes (Digenea: Schistosomatidae) as …

The Implementation Of Exercise For Chronic Kidney Disease And Dialysis Patients, Syed Ahmad Rizvi

Honors College Theses

While commonly known to be the organ that helps with urine production within the human body, the kidney plays one of the most crucial roles in maintaining homeostasis. When establishing all of the roles the kidney has on keeping humans healthy, there is the question of how does the body cope when a patient is diagnosed with kidney failure. One of the more common treatment options that allows the body to continue to function without a kidney is by beginning a patient on a form of dialysis. However, as with any treatment, there will always be a list of side …

Mechanical Thrombectomy For Acute Ischemic Stroke In The Cardiac Catheterization Laboratory., Steven A Guidera, Sudhir Aggarwal, J Doyle Walton, David Boland, Roy Jackel, Jeffrey D Gould, Brooke Kearins, Joseph Mcgarvey, Yan Qi, Brian Furlong

Department of Radiology & Diagnostic Medical Imaging

OBJECTIVES: The aim of this study was to determine the feasibility of establishing a mechanical thrombectomy (MT) program for acute ischemic stroke in a community hospital using interventional cardiologists working closely with neurologists.

BACKGROUND: American Heart Association/American Stroke Association 2018 guidelines give a Class I (Level of Evidence: A) recommendation for MT in eligible patients with large vessel occlusion stroke. Improvement in neurological outcomes with MT is highly time sensitive. Most hospitals do not have trained neurointerventionalists to perform MT, leading to treatment delays that reduce the benefit of reperfusion therapy.

METHODS: An MT program based in the cardiac catheterization …

The Effects And Implications Of Vaping On The Youth Population, Julia Sisson

Senior Honors Theses

Youth today have adopted the “cessation tool” known as the e-cigarette as a form of recreational activity. An examination of the history of tobacco use and prevention enables a fuller understanding of the problem presented by this product. Youth around the country are addicted to the sensation of vaping and are largely unaware of the associated health dangers. To address this growing issue among adolescents, vaping and its impact on the youth population should be carefully examined by health professionals. Although an overall solution has not yet been determined, there are several ways to impede the spread of the vaping …