Medicine and Health Sciences Commons^™

Perceptions Of Guilt Of Individuals With A Visible Communication Disorder Versus An Invisible Communication Disorder, Zoe Hochberg

Honors Scholar Theses

This study explored how communication disorders may impact listeners’ perception of guilt. More specifically, it looked at how visible communication disorders (e.g., stuttering) and invisible communication disorders (e.g., high functioning autism) are judged by the general public. 51 adults (18-71 years) participated in the study which asked them to view video recordings of narrative samples produced by an individual who stuttered (PWS), an individual with high-functioning autism (PHFA), and an individual with no communication disorder (PNCD). Participants were not informed of the individuals’ communication abilities (PWS, PHFA, or PNCD), but were told that one of the individuals had committed a …

Characterization Of A Mycoplasma Pneumoniae Cards Toxin Mutant, Nikaash Pasnoori

Honors Scholar Theses

Mycoplasma pneumoniae is a high-burden pathogen which causes mild to significant infections of the respiratory system. According to the CDC, an estimated two million cases occur yearly in the United States alone, demonstrating the widespread effect of the pathogen. In addition to being the cause of respiratory infections, M. pneumoniae has also been implicated in exacerbating pre-existing asthma conditions. These morbidities make finding a vaccine candidate a vital part of easing the healthcare burden caused by the pathogen. The current mechanism of infection is unknown, but recent evidence points to the Community Acquired Respiratory Distress Syndrome (CARDS) toxin as being …

Optical Clearing Reveals Tnbs-Induced Morphological Changes Of Vglut2-Positive Nerve Endings In The Colorectum, Shivam Patel

Honors Scholar Theses

Sensitization of colorectal afferents and colorectal hypersensitivity have been observed in a mouse model of post-infectious irritable bowel syndrome via intracolonic treatment of 2,4,6-trinitrobenzenesulfonic acid (TNBS). In this study, we investigated the distribution and morphology of microscopic colorectal afferent endings before and after intracolonic treatment of TNBS. We genetically labeled predominantly extrinsic colorectal afferents using the vesicular glutamate transporter type 2 (VGLUT2) promoter. Then, we used an optical tissue clearing method of whole-mount colorectum to image labeled VGLUT2-nerve endings that are otherwise obscured in untreated samples. We used vector path tracing to quantify the density and degree of curliness of …

Improving Caregiver Health Literacy Of Pediatric Febrile Illness: A Patient Care Initiative, Rebecca T. Shipley

DNP Final Reports

Background: Pediatric fever, though typically harmless and incredibly common, can cause substantial fear and anxiety for caregivers unfamiliar with how to manage or treat this condition at home. Studies evaluating pediatric emergency department (ED) rates have repeatedly found fever to be a leading reason for clinical evaluation. Local EDs record percentages as high as 40% of pediatric patients seek evaluation primarily for fever. Purpose: Provide educational resources for high-risk populations to reference at home regarding fever so that avoidable ED visits decreased and caregiver knowledge of fever improved. Methods: An educational program was implemented at a pediatric primary care clinic …

The Scoop, Vol. 7 Issue 2, May 2020, Health Sciences Library

Volume 7

Reporting the latest from your Health Sciences Library.

Individual Difference As A Factor In Ethical Decision-Making, Dan W. Reagan Jr.

Theses and Dissertations

Despite the dominance of modernistic ethics in counseling there has been a growing development of postmodern thought. There has been a growing understanding the limitations of ethical codes and purely rational thinking in ethical decision-making. Part of this new paradigm is an appreciation for the role of affect and context in the decision-making process. A post-modern approach to counseling ethics seems to be increasingly accepted among persons working in the social service field but little research has been attempted to evaluate the implications of such a change in training and practice. This study attempted to explore possible relationships between individual …

The Relationship Of Self-Efficacy And Clinical Reasoning Of Undergraduate Nursing Students, Amy G. Holder

Electronic Theses and Dissertations

Aim. This investigation aimed to discover if a there is a correlation between a student’s clinical reasoning self-efficacy and a student’s actual clinical reasoning ability. Also, this research sought to discover the connection between an undergraduate nurse’s self-efficacy of clinical reasoning and the locus of control of that student. Finally, this investigation sought to discover if perceived self-efficacy of clinical reasoning changed over time.

Background. The ability to successfully navigate the process of clinical reasoning is critical to providing safe, effective care for patients. For nurses, this process begins to develop in nursing school. Unfortunately, evidence suggests that newly graduated …

Neonatal Abstinence Syndrome And The Relationship Between Respiration And Feeding, Paul Rice

Electronic Theses and Dissertations

Objective: The primary purpose of this study was to determine the relationship between respiratory status and feeding difficulties in infants with NAS in comparison to full-term infants with no exposure to opioids.

Methods: A group of infants with NAS (262) were compared to a group of full-term infants with no exposure to opioids (279). These groups were further divided into feeding and respiratory groups based on severity. These groups were analyzed for differences in behavior and outcomes.

Results: Infants with NAS are 34.23 times more likely to develop respiratory distress and 111.03 times more likely to develop severe feeding difficulty. …

Exploring The Relationships Between Collegiate Sport Coaches’ Creative Productivity And Factors Of Creative Potential, Sean Flanders

Electronic Theses and Dissertations

Sport coaches are perceived as problem solvers who engage in creativity to handle the spontaneity of competitive activity and generate winning results. However, while creativity in athletes has been researched, little has been investigated regarding coaches. Therefore, the purpose of this study was to examine different aspects of creativity – person, process, press, and product – among collegiate team sport coaches in the United States. Specifically, how personality traits, ideational fluency, remote association ability, years of coaching experience, and work climate related to creative product impact and frequency. A modified creativity personality test was found to be positively …

A Replication And Extension Of A Prediction Tool Identifying Need For Treatment Among Opioid Exposed Infants, Loni Parrish

Electronic Theses and Dissertations

The incidences of maternal opioid use and neonatal opioid withdrawal syndrome (NOWS) have increased by nearly 400% over the past decade. Isemann and colleagues (2017) developed prediction tools (TiTE/TiTE²) to differentiate, within the first two days of life, between infants who will require pharmacotherapy for NOWS from those infants who will not require pharmacotherapy for NOWS. The goal of the current experiment was to replicate and extend their prediction model. The present experiments successfully replicated Isemann et al., (2017) results and also established alternative cutoff values for requiring treatment that provide better balance between all four metrics. Moreover, …

Evaluation Of User Interface In Drive Focus® Application, Bailey Kiser, Paul S. Peritos, Noreen Hasan, Anjelica J. Collins

Occupational Therapy | MSOT Capstone Projects

Technology is used in healthcare settings to aid clinicians in accessing client information, researching data, and enhancing communication with the client and other healthcare team members. In order for an app to best support client engagement, the app needs to have a well-developed user interface design There are four main aspects of user interface design, context, fidelity, accessibility, and consistency. The Drive Focus® application (app) is designed to identify how an individual recognizes, prioritizes, and reacts to information during real-world driving simulations. The Drive Focus® app has efficacy and feasibility, however, the user interface design has never been assessed. Therefore, …

Are All Instrumental Activities Of Daily Living Equal? A Pilot Study On The Performances Of Adults With Acquired Brain Injury, Crystal Lee, Samantha Schauer, Amy Tam, Yareli Vargas

Occupational Therapy | MSOT Capstone Projects

Aim: To determine if a relationship exists among performances of different instrumental activities of daily living (IADLs) in adults with acquired brain injury (ABI).

Methods: A two-group correlational design was used to examine the relationship among performances in cooking, medication management, and financial management in nine adults with ABI who returned to driving and nine adults with ABI who did not return to driving. The Executive Function Performance Test (EFPT) measured initiation, organization, sequencing, judgment and safety, and completion.

Translated Evidence-Based Mental Health Toolkit For Skilled Nursing Facilities, Natalie Crisostomo Barrales, Jan Martha Conducto, Cecelia Ly-Peh

Occupational Therapy | MSOT Capstone Projects

More than 500,000 adults with a serious mental illness (SMI) receive long term care (LTC) in a skilled nursing facility (SNF) (Grabowski, Aschbrenner, Feng, & Mor, 2009). Residents who live in SNFs may experience limited access to meaningful occupations. The SNFs’ institutionalized structure may perpetuate a lack of autonomy and stigma for residents with a SMI (Sullivan & Williams, 2017). Occupational therapy (OT) services provided in a SNF are often limited to therapeutic exercises, therapeutic activities, and activities of daily living skills (Rafeedie, Metzler, & Lamb, 2018). OT practitioners are not utilizing mental health interventions. Although SNFs are not traditionally …

Physiological Responses & Coping Strategies Of Sensory Defensive Adults, Benjamin Cohen, Alexandria Donaldson, Jenny Park-Chan, Jessica Valenzuela

Occupational Therapy | MSOT Capstone Projects

Purpose: The purpose of this study was to learn how adults cope with their sensory defensiveness (SD) and how physiological responses differ between adults who self-report as high SD versus low SD. Methods: In this continuation study participants (age 18-64; n=23) were categorized as low SD (control group; n=9) or high SD (experimental group; n=14) via their Adolescent Adult Sensory Profile (AASP) scores and Sensory Response Questionnaire (SRQ) scores (Brown, & Dunn, 2002 & Wilbarger, 2009). The last nine participants also completed the Coping Strategies Questionnaire (CSQ). All participants partook in the sensory challenge protocol which examined their electrodermal activity …

Impacts Of Assistive Technology Applications In Higher Education For Students With And Without Disabilities, Christine Jacob, Michelle Morello, Cayla Chapman, Grace Erhardt, Erin Camarena, Sara Delucchi, Bethany Young

Occupational Therapy | MSOT Capstone Projects

Current trends in higher education include an increased enrollment of students who have a disability and a rising trend of technology use within the classroom. Assistive technology (AT) has been shown to enhance academic success and influence learning strategies. Furthermore, the combination of AT and individualized support has the potential to promote and enhance engagement in meaningful occupations, such as participation in school, for individuals with and without disabilities. However, the procurement of AT alone can often have less impact than AT combined with individualized support. Occupational therapists (OT) can play a significant role in HE providing training and individualized …

Creating Focused Occupational Therapy Interventions For Clients With Heart Failure In Skilled Nursing Facilities, In Hwa Chae, Camille Marcia Schilling, Elena Ruth Vaccaro

Occupational Therapy | MSOT Capstone Projects

The ultimate goal of the SNF is to help clients stabilize their medical conditions and attain their therapy goals so that they can return home (Orr, Boxer, Dolansky, Allen, & Forman, 2016). However, approximately 27% of heart failure (HF) clients are readmitted to the hospital after being discharged from the SNF (Allen et al., 2011). High readmission rates may be due to the cognitive (Dickson, Tkacs, and Riegel, 2007), psychosocial (Halliday, 2010), and lifestyle barriers (Maeda, Shen, Schwarz, Farrell, & Mallon, 2013) HF clients face. However, interventions in the SNF tend to emphasize activities of daily living (ADLs) and therapeutic …

Five Year Evaluation Of The Complications Observed In Porcelain Fused To Metal (Pfm) Crowns Placed At A University Hospital, Shizrah Jamal, Rabia Ghafoor, Farhan Raza Khan, Kamil Zafar

Section of Dental-Oral Maxillofacial Surgery

Objective: To determine the frequency of complications in crowns cemented over a 5-year period in a tertiary care hospital and also to report the survival of these crowns.
Methods: The retrospective cross-sectional study was conducted at the Aga Khan University Hospital, Karachi, from March 2017 to March 2018 and comprised porcelain fused-to-metal crowns placed on the anterior or posterior teeth that were fabricated at the institutional laboratory and were placed in institutional dental clinics in the preceding 5 years. Porcelain-fused to-metal The crowns were clinically and radio-graphically evaluated in a duration of two months for presence/absence of complications. Factors associated …

Alternative Carbon Utilization As A Virulence Determinant For Candida Albicans, Robert Williams

Dissertations and Theses (Open Access)

Candida albicans is a polymorphic unicellular fungus that has evolved to proficiently colonize and infect mammals. A common constituent of the microbiome in the GI tract, mouth, vagina, and skin, C. albicans is also an opportunistic pathogen capable of causing a variety of mucosal infections and the life-threatening disseminated candidiasis. Systemic C. albicans infections are a serious and growing issue; the fungus is the fourth most common cause of nosocomial bloodstream infections which has a mortality rate reaching 50%. As antifungal resistance continues to rise, it is critical that I understand the molecular basis of disseminated fungal infections.

The phagocytes …

Depression Is Associated With Decreased Severity And Lower Mortality In Non-Elderly Hospitalized Adults With Influenza In The United States, Timothy L. Wiemken, Daniel Hoft, Jeffrey Scherrer

The University of Louisville Journal of Respiratory Infections

Background: Depression is associated with risk for chronic disease, though its relationship with infectious diseases is less understood. Depression may modify the clinical outcomes of patients with infectious diseases such as influenza via its association with inflammation. The objective of this study was to evaluate the relationships between depression and clinical outcomes in non-elderly adults with influenza infection.

Methods: This was a secondary analysis of the Nationwide Inpatient Sample database, years 2012–2016. Hospitalized adults aged 18–65 admitted during each influenza season were included. Depression status was documented via ICD-10 codes. The association between depression and clinical outcomes (e.g., …

The Criterion Collection, Mackenna Finley

Honors Projects

The Criterion Collection is an examination of truth in fiction and poetry. The goal of this project is not to create truth that is absolute, but instead to allow for the experience of its subjectivity. The interplay between fiction and poetry, reader and author illuminates the subtle warping of truth through human experience.

Changes In Countermovement Jump And Sprint During A Congested Match Schedule In Female Youth Soccer Players, Joanne Spalding

Electronic Theses and Dissertations

Youth soccer players are required to play multiple matches within a short period of time. Participation in congested match schedules like youth soccer tournaments can result in fatigue and a decline in physical performance. The purpose of this study was to examine changes in countermovement jump height variables and sprint time to determine if physical performance was altered. Fourteen youth female soccer players performed countermovement jump testing pre, post-match, and post-tournament, and sprint testing pre and post-tournament. Jump height differed significantly (p

The Experiences And Well-Being Of Mexican Immigrant Women Living In Traditionally Non-Latinx Communities In Western North Carolina, Melinda Bogardus

Electronic Theses and Dissertations

North Carolina has, in recent decades, experienced significant growth in its Latinx, and more particularly Mexican immigrant population. As a traditionally non-Latinx state, or a state without a long-standing, large Latinx population, many communities and healthcare and service providers within North Carolina still lack knowledge, resources, and skills needed to serve and support Latinx immigrant populations well. Guided by interpretive description, this qualitative study on Mexican immigrant women in Western North Carolina sought to gain knowledge and understanding of what it is like for them to live in a traditionally non-Latinx region and how immigration has affected their well-being. Asking …

Behavioral And Neurobiological Evidence Of Epigenetic Transmission In The Neonatal Quinpirole Rodent Model Of Schizophrenia, Wesley Gill

Electronic Theses and Dissertations

Quinpirole is a dopamine D2 receptor agonist that if administered to rats from postnatal day (P)1-21 results in increased dopamine D2 receptor sensitivity throughout the animal’s lifetime. This increase in receptor sensitivity is consistent with schizophrenia. This model has additional consistencies with human schizophrenia, including sensorimotor gating deficits, enhanced behavioral and neurobiological responses to nicotine, and protein alterations consistent with the disorder. In this study, a second generation of the neonatal quinpirole (NQ) rodent model was created to investigate if long term changes caused by NQ treatment would be passed to offspring. NQ treated rats were mated and their offspring …

Listeners’ Attitudes Towards Young Women With Glottal Fry, Natalie Foulks

Electronic Theses and Dissertations

Objective: The purpose of this study was to identify employers’ perceptions of young women using glottal fry and the impact on hirability.

Methods: A survey was created using the online survey tool, REDCapÒ, and sent to employers across the southern United States. The survey contained three voice samples consisting of a non-glottal fry voice, a glottal fry at the end of sentences voice, and a continuous glottal fry voice, fourteen semantic differential scales derived from hiring constructs, and open-ended questions on hirability.

Results: Employers perceived individuals using glottal fry as more negative than the individual who used no glottal fry. …

Association Of Perfluorinated Chemicals With Endocrino-Carcinogenetic, Obesogenic And Metabolic Health And With Markers Of Chronic Inflammation And Oxidative Stress, Ogbebor Enaholo Omoike

Electronic Theses and Dissertations

First, this study examined the association of perfluorinated chemicals with 1) cardio-metabolic health outcomes and 2) the association of phthalates with cardiometabolic health outcomes, and 3) cardio-metabolic health outcomes while assessing the possibility of additive interactions between perfluorinated chemicals (PFCs) and phthalates. Second, association with markers of chronic inflammation and oxidative stress were explored. Finally, this study examined the association of these chemicals with estrogenic cancers- Breast cancer, prostate cancer, uterine cancer and ovarian cancer.

Using data from the National Health and Nutrition Examination Survey (NHANES), logistic regression models were used to investigate the relationship between PFCs and the cardio-metabolic …

A Protocol Driven Stroke Code's Impact On Door-To-Needle Times, Jesse Osborne

Electronic Theses and Dissertations

Tissue plasminogen activator (tPA) is most effective the faster it is able to be administered to a patient that has been affected by stroke. A Stroke Code is a strategy that acute care facilities implement to reduce the time from diagnosing a stroke to administering tPA. The purpose of this study was to determine if the initiation of a Stroke Code in an acute care hospital reduces the door-to-needle time for patients affected by a stroke. In particular, does a Stroke Code reduce door-to-needle times. The research was conducted using data from April 1, 2014 to December 31, 2014 (pre-Stroke …

The Impact Of State-Level Laws On Syringe Service Program Access And Risk Environment Of People Who Inject Drugs (Pwid), Samuel Pettyjohn

Electronic Theses and Dissertations

Background: Understanding concentrated areas with high rates of opioid use disorder (OUD) allows for improved placement of Narcan access points through syringe services programs (SSPs). People Who Inject Drugs (PWID) have lower risk of contracting infectious diseases the closer they are to SSPs. Tennessee law prohibits SSPs within 2000ft of a school or park, impacting the placement of SSPs in non-urban areas. Testing factors related to SSP siting placement within a system dynamic model can better determine the relationship between PWID risk environment and SSP access and utility.

Methods: We identified areas of greatest need for harm reduction interventions within …

In Vitro Bioactivities Of Single Or Combined Extracts From Three Selected Asian Vegetables, Mahmud Norfaizah

Student Works (2020-2029)

Three underutilized folklore oriental-based vegetables Acalypha indica (AI), Centella asiatica (CA), and Sesbania grandiflora (SG) have been investigated for pharmacological activities relevant to wound healing process and synergistic actions. Single and combination of aqueous (A) and methanol (M) extracts of the three vegetables namely AI-A, CA-A, SG-A, AI-M, CA-M, SG-M, AI-A+CA-A, AI-A+SG-A, CA-A+SG-A, AI-M+CA-M, AI-M+SG-M, and CA-M+SG-M were assessed for stimulation of wound closure by normal human dermal fibroblast (NHDF) cells, antioxidant, protection against hydrogen peroxide (H2O2), stimulation of nitric oxide (NO) from RAW264.7 macrophages and antimicrobial activities. The combined vegetable extracts AI-A+CA-A (90.76%) showed the highest percentage of wound …

The Coronavirus And The Risks To The Elderly In Long-Term Care, William Gardner, David States, Nicholas Bagley

Articles

The elderly in long-term care (LTC) and their caregiving staff are at elevated risk from COVID-19. Outbreaks in LTC facilities can threaten the health care system. COVID-19 suppression should focus on testing and infection control at LTC facilities. Policies should also be developed to ensure that LTC facilities remain adequately staffed and that infection control protocols are closely followed. Family will not be able to visit LTC facilities, increasing isolation and vulnerability to abuse and neglect. To protect residents and staff, supervision of LTC facilities should remain a priority during the pandemic.

Whatever Happened To Evidence-Based Practice During Covid-19?, Helene J. Krouse

School of Medicine Publications

Contemporary medical practice is grounded in rigorous scientific evidence in concert with best clinical practices and informed shared decision making with patients. During these times of uncertainty, disruption, and even anxiety, it becomes critical that we engage with our patients and communities in thoughtful dialogue and realistic expectations regarding treatments surrounding COVID-19. The hope for a “miracle” cure and urgency to return back to normal times can stimulate irrational thought and behavior and even desperate measures by individuals or groups. It becomes especially important that we continue to use reasonable, informed clinical judgment in discussing the various options with patients.