Medicine and Health Sciences Commons^™

Highlights Of Studies In Cardiovascular Disease Prevention Presented At The 2020 American College Of Cardiology Annual Scientific Session, Xiaoming Jia, Mahmoud Al Rifai, Jing Liu, Anandita Agarwala, Martha Gulati, Salim S Virani

Faculty, Staff and Students Publications

PURPOSE OF REVIEW: The review highlights selected studies related to cardiovascular disease (CVD) prevention that were presented at the American College of Cardiology 2020 Virtual Scientific Session (ACC.20)/World Cardiology Congress (WCC).

RECENT FINDINGS: The studies reviewed include clinical trials on the efficacy and safety of alirocumab (Study in Participants with Homozygous Familial Hypercholesterolemia [ODYSSEY HoFH]) and evinacumab in the treatment of homozygous familial hypercholesterolemia (HoFH); Evaluating the Efficacy of E-cigarettes for Smoking Cessation (E3); the use of renal denervation in the treatment of hypertension (SPYRAL HTN-OFF MED PIVOTAL); and the assessment of vericiguat in the treatment of heart failure (A …

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Georgia Southern student research shows Georgia doing well in stopping spread of COVID-19 but is still home to 4 of the nation’s 10 highest counties for mortality rate

Update On University Travel, June 18, 2020, University Of Northern Iowa

UNI Response to COVID-19

An announcement from June 18th updating the travel guidelines for university-sponsored travel, allowing for in-state travel and requiring pre-approval of travel within the United States. International travel is still prohibited at this point.

Impacts Of Motor And Sensory Impairment On Language In Young Children With Autism, Elizabeth A. Bisi

Clinical Psychology Dissertations

Children with autism spectrum disorder (ASD) present with varying degrees of deficit in the broader areas of social communication and stereotyped behaviors, but emerging research proposes delayed motor skill and atypical sensory processing as additional factors worth closer examination. In the current study, I sought to investigate the impacts of visual motor skills and sensory differences on language ability in young children with autism. I hypothesized that young children with autism, atypical sensory processing (Short Sensory Profile, 2^nd Edition), and impaired visual motor integration (Beery VMI, 6^th Edition) would have the most impacted language ability scores (Differential Ability …

Do New Trainees Pose A Threat To Postoperative Complications After Hip Fracture Surgeries? Retrospective Cohort Of 1045 Patients Over A Decade At A University Hospital, Obada Hasan, Mashal Amin, Umar Rabbani, Amna Rabbani, Fatima Mahmood, Shahryar Noordin

Department of Paediatrics and Child Health

Introduction: Induction of new residents and surgical trainees in most institutes occurs once a year. Fresh residents with no experience, may pose a threat to the surgical procedure outcome and there can be a potential increase in patients' morbidity and mortality as a result of this turnover. Literature is inconclusive about this effect. Our aim was to study the "new residents' induction effect" on postoperative complications after hip fracture surgeries.
Methodology: This is non funded non commercialized study from a university hospital. Investigators studied a retrospective cohort of 1045 adult hip fracture patients who were operated at our tertiary care …

Effectiveness Of Home-Based Rehabilitation Program In Minimizing Disability And Secondary Falls After A Hip Fracture: Protocol For A Randomized Controlled Trial, Anum Sadruddin Pidani, Saniya Sabzwari, Khabir Ahmad, Ata Khan, Shahryar Noordin

Department of Surgery Docs

Introduction: Hip fractures are a major health problem globally and are associated with increased morbidity, mortality, and substantial economic costs. Successful operative treatment of hip fracture patients is necessary for the optimization of post-op mobility and functional recovery of the patient. Rehabilitation after surgical stabilization of a hip fracture is crucial in order to restore pre-fracture function and to avoid long-term institutionalization. In particular ongoing exercise which targets balance can prevent up to 40% of falls. Therefore, we have designed a post-discharge home-based physical rehabilitation intervention program to minimize disability and falls in this high-risk elderly population.
Methods and analysis: …

2020-06-17_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

2020-06-17_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

The webpage was obtained from Michigan's Coronavirus Cumulative Data page, under the link Data About Places. Data is self-reported by hospitals daily to the EM Resource System per MDHHS Director Robert Gordon's Emergency Order.

Contains the tables Statewide Available Bed Tracking for COVID-19, COVID-19 Metrics, Statewide Available PPE Tracking for COVID-19 (Statewide Available PPE and Bed Tracking), as well as the tables PPE Days On Hand and Patient Census.

2020-06-17_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) and rapid virus antigen detection point of care (POC) tests, look for current infection. Serology (antibody) tests are used to look for the possibility of previous infection.
Source: Michigan Disease Surveillance System (MDSS) and Vital Records

The website contained the tables …

2020-06-17_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Longitudinal Changes Of Brain Microstructure And Function In Non-Concussed Female Rugby Players, Douglas Fraser

Data and Test Instruments

No abstract provided.

Stroke Management In The Time Of Covid, Marwa Elnazeir, Siddharth Narayanan, Kerri Remmel

The University of Louisville Journal of Respiratory Infections

No abstract provided.

Effectiveness Of High-Fidelity Simulation In Training Emergency Medicine Physicians In Point Of Care Ultrasonography In Pakistan: A Quasi-Experimental Study, Kiran Azizi, Madiha Ismail, Umaira Aftab, Badar Afzal Khan, Asad Mian

Department of Emergency Medicine

Background: Point-of-care ultrasound (PoCUS) is frequently utilized in emergency medicine (EM), with an extended-focused assessment with sonography in trauma (e-FAST) being the most widely used PoCUS modality. This modality is not only time- and cost-efficient, but it is highly accurate in the diagnosis and management of surgical patients in the emergency department, as well as being highly predictive of patient outcomes. Targeted training is essential to ensure a learner's confidence in image acquisition, interpretation, and translation of knowledge to making clinical decisions. High-fidelity simulation offers a uniquely safe and "mistake-forgiving" environment to teach and train medical professionals. The present study …

2020-06-17_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services

Michigan COVID-19 Long Term Care Data

The COVID Long Term Care Facilities page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173-526911--,00.html.

This report is created by the Michigan Department of Health & Human Services from data self-reported by long-term care facilities into EMResource. Data is updated on an ongoing basis.

The data below represents a cumulative total of confirmed COVID-19 resident cases, cumulative total of suspected and confirmed resident deaths, cumulative total of confirmed COVID-19 staff cases, and cumulative total of suspected and confirmed staff deaths reported by SNFs in Michigan since January 1, 2020. Case numbers are provisional and may change as facilities correct …

Leiomyosarcoma Of Prostate: A Case Report And Literature Review, Abdeljalil Heddat, Younes Houry, Redouane Rabii

Health Sciences

Prostate leiomyosarcoma is an extremely rare and very aggressive neoplasm that represents less than 0.1% of primary malignant tumors of the prostate. We present a patient with primary leiomyosarcoma of the prostate and examine the cases reported in the literature to discuss the clinical, diagnostic, and therapeutic aspects of this rare tumor. Median survival was estimated at 17 months (95% CI 20.7–43.7 months) and the actuarial survival rates at 1, 3, and 5 years were 68%, 34%, and 26%, respectively. The only predictors of long-term survival were negative surgical margins and the absence of metastatic disease at presentation. A multidisciplinary …

Recurrent Takotsubo Cardiomyopathy In A Patient With Hypertrophic Cardiomyopathy Leading To Cardiogenic Shock Requiring Va-Ecmo, Mustafa Husaini, Joshua N Baker, Sharon Cresci, Richard Bach, Shane J Larue

2020-Current year OA Pubs

Providing hemodynamic support for patients with hypertrophic cardiomyopathy and cardiogenic shock can be challenging because inotropic medications worsen intraventricular obstruction, and the effect of appropriate mechanical support remains undefined. We report a patient with hypertrophic cardiomyopathy in shock because of takotsubo cardiomyopathy requiring venoarterial extracorporeal membrane oxygenation and septal reduction for full recovery. (

25-Hydroxycholesterol Amplifies Microglial Il-1Β Production In An Apoe Isoform-Dependent Manner, Man Ying Wong, Michael Lewis, James J Doherty, Yang Shi, Anil G Cashikar, Anna Amelianchik, Svitlana Tymchuk, Patrick M Sullivan, Mingxing Qian, Douglas F Covey, Gregory A Petsko, David M Holtzman, Steven M Paul, Wenjie Luo

2020-Current year OA Pubs

BACKGROUND: Genome-wide association studies of Alzheimer's disease (AD) have implicated pathways related to lipid homeostasis and innate immunity in AD pathophysiology. However, the exact cellular and chemical mediators of neuroinflammation in AD remain poorly understood. The oxysterol 25-hydroxycholesterol (25-HC) is an important immunomodulator produced by peripheral macrophages with wide-ranging effects on cell signaling and innate immunity. Cholesterol 25-hydroxylase (CH25H), the enzyme responsible for 25-HC production, has also been found to be one of the disease-associated microglial (DAM) genes that are upregulated in the brain of AD and AD transgenic mouse models.

METHODS: We used real-time PCR and immunoblotting to examine …

Encuesta De Conocimientos, Actitudes Y Prácticas Del Covid-19: Informantes Clave En 10 Municipios Con Población Indígena De Guatemala, Population Council

Poverty, Gender, and Youth

No abstract provided.

Development And Validation Of Wearable Inertial Sensor System For Postural Sway Analysis, Michael Pollind, Rahul Soangra

Physical Therapy Faculty Articles and Research

Postural sway is a fall risk assessment tool traditionally measured using forceplates. However, it is expensive and lack portability to usage in clinical environments. In this study, a wearable low-cost MEMS inertial sensor was developed and validated for sway assessment. This study had two principal objectives (1) To develop and validate an Inertial Measurement Unit (IMU) for sway analysis (2) To assess the feasibility of IMU in detecting slight balance impairments due to reduced proprioception or induced subthreshold vibrations on the feet. A total of 10 healthy young adults (five males and five females) participated in this study. We found …

The Effects Of Distracting Background Audio On Speech Production, Camille Margaret Cowley

Theses and Dissertations

This study examined changes in speech production when distracting background audio is present. Forty typically speaking adults completed a repetitive sentence reading task in the presence of 5 different audio conditions (pink noise, movie dialogue, heated debate, classical music, and contemporary music) and a silent condition. Acoustic parameters measured during the study included vowel space area (VSA), vowel articulation index (VAI), formant transition extent, formant transition rate, and diphthong duration for /ɑɪ/ and /É‘ÊŠ/. It was hypothesized that there would be significant increases in vowel space area and vowel articulation index as well as an increase in formant transition measures …

The Role Of Threat And Efficacy In Anti-Vaping Ads: A Test Of The Extended Parallel Process Model, Ryan Noone

USF Tampa Graduate Theses and Dissertations

Often thought of as a safer alternative to traditional cigarettes, electronic cigarette use among youth and young adults has steadily increased over the past 10 years. With over 34 percent of high school students and over 7.8 percent of young adults using electronic cigarettes, organizations like the CDC and the FDA have created campaigns and advertisements to combat the epidemic (Truth Initiative). This study uses a 2x2 between subject factoral experiment to gain insights into how varying levels of anti-vaping advertisements’ threat and efficacy elements effect college age students’ perceptions and behaviors towards e-cigarettes. While several of the study’s hypotheses …

Aptamer Hybrid Nanocomplexes As Targeting Components For Antibiotic/Gene Delivery Systems And Diagnostics: A Review, Navid Rabiee, Sepideh Ahmadi, Zeynab Arab, Mojtaba Bagherzadeh, Moein Safarkhani, Behzad Nasseri, Mohammad Rabiee, Mohammadreza Tahriri, Thomas J. Webster, Lobat Tayebi

School of Dentistry Faculty Research and Publications

With the passage of time and more advanced societies, there is a greater emergence and incidence of disease and necessity for improved treatments. In this respect, nowadays, aptamers, with their better efficiency at diagnosing and treating diseases than antibodies, are at the center of attention. Here, in this review, we first investigate aptamer function in various fields (such as the detection and remedy of pathogens, modification of nanoparticles, antibiotic delivery and gene delivery). Then, we present aptamer-conjugated nanocomplexes as the main and efficient factor in gene delivery. Finally, we focus on the targeted co-delivery of genes and drugs by nanocomplexes, …

The Clinical Features Of Co-Circulating Dengue Viruses And The Absence Of Dengue Hemorrhagic Fever In Pakistan, Erum Khan, Dhani Prakoso, Kehkashan Imtiaz, Faisal Malik, Joveria Farooqi, Maureen T. Long, Kelli L. Barr

Department of Pathology and Laboratory Medicine

Dengue virus (DENV) is the most common and widespread arboviral infection worldwide. Though all four DENV serotypes cocirculate in nature, the clinicopathological framework of these serotypes is undefined in Pakistan. A cross-sectional, observational study was performed to document the circulation of various arboviruses in the Sindh region of Pakistan. Here we describe a population of patients diagnosed with DENV spanning a 2-year period. This study used an orthogonal system of NS1 antigen ELISA followed by RT-PCR for DENV detection and subtyping. A total of 168 NS1 positive patients were evaluated of which 91 patients were serotyped via RT-PCR. There was …

07-07-20 Hsc Committee Meeting Notice, Hsc Committee

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

Acute Tubular Injury In A Patient On A Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor, June K Pickett, Maulin Shah, Michael Gillette, Peter Jones, Salim Virani, Christie Ballantyne, Vijay Nambi

Faculty, Staff and Students Publications

A 72-year-old man with coronary artery disease, statin intolerance, and chronic kidney disease stage IIIa was initiated on alirocumab, a proprotein convertase subtilisin/kexin type 9 inhibitor, and developed acute kidney injury. A kidney biopsy was performed and suggested acute tubular injury. The serum creatinine returned to baseline after discontinuation of alirocumab. (Level of Difficulty: Intermediate.)

Compliance Of Smokeless Tobacco Supply Chain Actors And Products With Tobacco Control Laws In Bangladesh, India And Pakistan: Protocol For A Multicentre Sequential Mixed-Methods Study, Zohaib Khan, Rumana Huque, Aziz Sheikh, Anne Readshaw, Jappe Eckhardt, Cath Jackson, Mona Kanaan, Romaina Iqbal, Zohaib Akhter, Javaid Khan

Community Health Sciences

Introduction: South Asia is home to more than 300 million smokeless tobacco (ST) users. Bangladesh, India and Pakistan as signatories to the Framework Convention for Tobacco Control (FCTC) have developed policies aimed at curbing the use of tobacco. The objective of this study is to assess the compliance of ST point-of-sale (POS) vendors and the supply chain with the articles of the FCTC and specifically with national tobacco control laws. We also aim to assess disparities in compliance with tobacco control laws between ST and smoked tobacco products.
Methods and analysis: The study will be carried out at two sites …

Prevention Of Sports Injuries In Sri Lanka: What Do We Know About Injuries In Our Athletes?, Prasanna J. Gamage, Alex Kountouris, Caroline F. Finch, Lauren V. Fortington

Research outputs 2014 to 2021

In terms of safeguarding the health and well-being of athletes in Sri Lanka, a primary focus has always been toward the treatment of injuries after they have occurred and promoting rehabilitation back into sport. There has been little attention towards the primary prevention of injuries in Sri Lankan sports. As a developing sporting nation, the benefits of injury prevention are immense: from a public health and financial perspective, through to individual benefits for athletes’ physical, psychological and social health. Understanding the reasons behind the lack of motive towards sports injury prevention in the country, and challenges in developing and implementing …

Medication Safety During Transitions Of Care:The Importance Of Checklists In Preventing Patient Harm, Laressa Bethishou, Olivia Lounsbury, Donna Prosser

Pharmacy Faculty Articles and Research

There is a need to optimize patient safety as patients navigate through the healthcare system. With each transition of care, patients are vulnerable to changes that may cause adverse effects, including changes in their healthcare team, health status, and medications. The Centers for Medicare & Medicaid Services (CMS) defines a transition of care as “the movement of a patient from one setting of care to another.” While the concept itself may seem simple, this definition fails to capture the many potential handoff complications which classify these transitions as high risk for patients. With 67% of patients facing unintended medication discrepancies …

Choosing Whom To Trust: Autonomy Versus Reliance On Others In Medical Decision Making Among Plain Anabaptists, Michael Sauder

Journal of Amish and Plain Anabaptist Studies

The idea of patients as autonomous agents dominates the medical ethics literature in Europe and America. I maintain that Plain Anabaptists allow their communities to influence medical therapy decisions more than the typical American does. They choose differently whom to trust. This is relevant to medical professionals interacting with them, especially when Plain Anabaptists make decisions at variance with standard medical recommendations. The typical American doctor will often mistake the area of disagreement, assuming that the presentation of more facts will sway the patient. However, the emphasis on community and acceptance of authority means that Plain Anabaptists will have a …

Efficient Method Of Delivery For Powdered Supplement Or Placebo For An Outdoor Exercise Investigation, R W. Salatto, Dustin W. Davis, Bryson Carrier, Brenna Barrios, Jacquelyn Sertic, Peyton Cater, James W. Navalta

Topics in Exercise Science and Kinesiology

• Researchers often encounter issues while attempting to deliver complete doses of a desired supplement/placebo when conducting research in outdoor environments. The problem faced by our research team was how to efficiently deliver 6.4 grams of Beta Alanine (BA) powder to subjects while conducting a hiking study on a windy trail in Southern Utah. To minimize the potential impact of the weather, and to maximize the efficiency of delivery, we determined a premixed bolus of BA contained in individual commercially available 8oz water bottles was the most efficient delivery method. The purpose of this article is to detail the development and …