Medicine and Health Sciences Commons^™

Employee Information - Fall Protocols, July 11, 2020, University Of Northern Iowa

UNI Response to COVID-19

A memo from Human Resources to faculty and staff giving policies and procedures that need to be reviewed prior to the beginning of the Fall 2020 Semester.

Catastrophic Cardiac Complications Of Takayasu's Arteritis., Sara Godil Md, Bilal Saqi Md, Kareem Godil Md, Syed Rafay Ali Sabzwari, Yasotha Rajeswaran Md

Department of Medicine

Takayasu's arteritis (TA) causes inflammation and necrosis of vessel walls, leading to aneurysm formation, extensive coronary damage and valvular abnormalities. We review a case of recurrent coronary, aortic and mitral valve involvement in a patient with TA and discuss the various treatment options available for such patients.

Endocrine Significance Of Sars-Cov-2'S Reliance On Ace2, Eric Lazartigues, Mirza Muhammad Fahd Qadir, Franck Mauvais-Jarvis

School of Medicine Faculty Publications

The current COVID-19 pandemic is the most disruptive event in the past 50 years, with a global impact on health care and world economies. It is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a coronavirus that uses angiotensin-converting enzyme 2 (ACE2) as an entry point to the cells. ACE2 is a transmembrane carboxypeptidase and member of the renin-angiotensin system. This mini-review summarizes the main findings regarding ACE2 expression and function in endocrine tissues. We discuss rapidly evolving knowledge on the potential role of ACE2 and SARS coronaviruses in endocrinology and the development of diabetes mellitus, hypogonadism, and pituitary and …

An Autoethnography Of A Registered Nurse Living With Chronic Undiagnosed Illness, Frances M. Ricker

Nursing ETDs

Abstract

This autoethnographic study examines a registered nurse’s experience living with chronic undiagnosed illness. The number living with undiagnosed illness is unknown and little is understood about living with chronic undiagnosed illness.

This analytic autoethnography (Anderson, 2006) used multiple data sources: my journal, medical history narrative, and artifacts including my handwork, examples of my father’s handwriting, and family photographs. Narrative analysis, thematic analysis, and visual analysis were conducted.

My experience of living with chronic undiagnosed illness was characterized by three themes that reinforced isolation: not knowing, loss, and hidden secret self. Family context evidenced diverse themes of not being believed, …

2020-07-10_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Veterans Helping Veterans Mid-Day Talk: Gulf War Illness Research, Bill Watts, Elizabeth G. Balbin

INIM Research Seminar Series

• Meet the Gulf War Illness Research Team.
• Learn about the ease of participating in research.
• Hear from veterans who have participated in research.
• Learn about different studies currently available.

School Of Pharmacy Intellectual Property Report Fy20, Fourth Quarter Report, Soumyajit Majumdar

U. S. Patents, School of Pharmacy

School of Pharmacy Intellectual Property Report FY20, Fourth Quarter Report (as of 6/30/20)

Utilizing Mindfulness-Based Exercises To Reduce Anxiety Severity Scores According To The Gad-7, Kelly Calhoun

Dissertations

Abstract

Problem: Generalized anxiety disorder (GAD) affects thousands of Americans every year. Mindfulness, a practice of bringing oneself into the present moment, has been shown to impact anxiety symptoms positively.

Objective: This prospective observational correlational study utilized mindfulness-based exercises to help decrease anxiety severity according to the generalized anxiety disorder-7 (GAD-7) in an outpatient psychiatric practice.

Methods: Participants practiced mindfulness exercises for two months. The GAD-7 was completed three times to monitor symptom severity. Two participant satisfaction surveys were completed to determine whether participants felt the exercises were beneficial for decreasing their anxiety.

Results: A repeated measures ANOVA was used …

Bridging The Gap In Primary Care Of Inflammatory Bowel Disease (Ibd) Patients, Deanna Dial

Dissertations

Abstract

Problem. Patients in rural or medically underserved areas (MUAs) with inflammatory bowel disease (IBD) have limited access to primary care preventative services, making them even less likely to obtain preventative care, placing them at even greater risk for adverse health outcomes.

Methods. A two-phase retrospective chart review utilizing a convenience sample of patients diagnosed with IBD from a privately-owned gastroenterology office to evaluate the effectiveness of increasing preventative screenings for IBD patients. The first review included 53 patients seen from January to April 2019. A preventative screening

evaluation tool (PSET) was developed based on literature recommendations, including the American …

Effects Of Genetic Testing On Clinical Outcomes Of Patients With Obsessive Compulsive Disorder, Jessica Higlen

Dissertations

Problem: The National Institute for Mental Health (NIMH) reports that only 1.2% of adults suffer from OCD, but over 50% are severe (Obsessive Compulsive Disorder (OCD), n.d.). Meier et al. (2016), found that patients with OCD faced a 40% higher chance of early mortality. Individuals with psychiatric conditions are more at risk for poor physical health, poor education, economic struggles and crime (Mental Health by the Numbers, 2019). Emergency departments claim tens of millions of visits per year related to psychiatric issues resulting in billions in costs each year (Mental Health by the Numbers, 2019). Genetic testing is becoming a …

2020-07-10_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

2020-07-10_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services

Michigan COVID-19 Hospital Data

The webpage was obtained from Michigan's Coronavirus Cumulative Data page, under the link Data About Places. Data is self-reported by hospitals daily to the EM Resource System per MDHHS Director Robert Gordon's Emergency Order.

Contains the tables Statewide Available Bed Tracking for COVID-19, COVID-19 Metrics, Statewide Available PPE Tracking for COVID-19 (Statewide Available PPE and Bed Tracking), as well as the tables PPE Days On Hand and Patient Census.

Diversity In Pre-Nursing Majors And Nursing Program Applicants, Christel Fehr

Dissertations

Problem: The population of the US has become increasingly ethnically diverse. This diversity has not been reflected in the nursing workforce with approximately 70% being Caucasian and 85% being female, resulting in a disparity in healthcare delivery by minorities. The purpose of this project was to perform an analysis of race, ethnicity, and gender diversity in undergraduate nursing applicants at a rural midwestern university.

Method: A retrospective review of nursing applications, enrollment reports, and graduation rates were examined for three academic years.

Results: 326 students (N=326) applied to the nursing program from Fall 2016 through Spring 2019. Of …

Nurse Practitioner Student Confidence And Competence In Common Women's Health Diagnostic Procedures, Jessica Cowan

Dissertations

Problem: In areas with limited health resources, such as Guatemala, cost-effective and reliable methods for sexually transmitted infection and cervical cancer screenings are needed. The purpose of this Quality Improvement (QI) project was to develop standardized training in Vaginal Wet Mount (VWM) preparation and cervical cancer screening using Visual Inspection with Acetic Acid (VIA) for Nurse Practitioner students who traveled to Guatemala for a week-long global immersion experience.

Methods: This was a QI project with a prospective descriptive design utilizing a purposive sample of 10 University of Missouri-St. Louis Nurse Practitioner students who traveled to Guatemala on medical mission trip …

Olfaction Modulates Inter-Subject Correlation Of Neural Responses, Paul Deguzman, Anshul Jain, Matthias H. Tabert, Lucas C. Parra

Publications and Research

Odors can be powerful stimulants. It is well-established that odors provide strong cues for recall of locations, people and events. The effects of specific scents on other cognitive functions are less well-established. We hypothesized that scents with different odor qualities will have a different effect on attention. To assess attention, we used Inter-Subject Correlation of the EEG because this metric is strongly modulated by attentional engagement with natural audiovisual stimuli.We predicted that scents known to be “energizing” would increase Inter-Subject Correlation during watching of videos as compared to “calming” scents. In a first experiment, we confirmed this for eucalyptol and …

Screening For Delirium In The Emergency Department, Melissa Minks

Dissertations

Abstract

Delirium is a problem for many older adults who are acutely ill. Delirium often comes on suddenly, can be severe, and is often difficult to diagnose, especially in the presence of dementia. Missed delirium has a mortality rate of 30.8% and costs millions. What is the purpose of this study?

Methods The 4A’s Test screening instrument was implemented and evaluated in the Emergency Department of a rural Midwestern hospital from May 1, 2019 through August 31, 2019.

Results There were 122 participants in the study with 61 in each cohort. In 2018, three (5%) were diagnosed with delirium without …

Evaluation Of Mcgeer Criteria For Uti Determination In A Nursing Home, Julie Rehagen

Dissertations

Problem: Urinary tract infection (UTI) is one of the most complex and challenging medical diagnoses to make in the long-term care (LTC) population. The unnecessary treatment of a UTI can increase cost of care and the likelihood of multi-drug resistant organisms.

Methods: The McGeer criteria which focuses on UTI in the LTC population was utilized to complete a quality improvement initiative. A descriptive cohort project utilizing retrospective and prospective data was completed to determine if an implemented McGeer criteria protocol improved the avoidable treatment of asymptomatic bacteriuria (ASB).

Results: Before implementation of the protocol, 62.5% of residents were unnecessarily treated …

Wonder If You’Ll Get Huntington’S Disease? Preparing For The Big, 'Intensely Personal' Decision To Undergo Predictive Testing, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

2020-07-10_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services

Cumulative Michigan COVID-19 Data

The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.

This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) and rapid virus antigen detection point of care (POC) tests, look for current infection. Serology (antibody) tests are used to look for the possibility of previous infection.
Source: Michigan Disease Surveillance System (MDSS) and Vital Records

The website contained the tables …

Enhancement Of Fast Scan Cyclic Voltammetry Detection Of Dopamine With Tryptophanmodified Electrodes, Sarah E. Davis, Andrew L. Korich, Eric S. Ramsson

Peer Reviewed Articles

Fast scan cyclic voltammetry (FSCV) allows for real -time analysis of phasic neurotransmitter levels. Tryptophan (TRP) is an aromatic amino acid responsible for facilitating electron transfer kinetics in oxidoreductase enzymes. Previous work with TRP-modified electrodes showed increased sensitivity for cyclic voltammetry detection of dopamine (DA) when used with slower scan rates (0.05 V/s). Here, we outline an in vitro proof of concept for TRP-modified electrodes in FSCV detection of DA, and decreased sensitivity for ascorbic acid (AA). TRP-modified electrodes had a limit of detection (LOD) for DA of 2.480 ± 0.343 nM compared to 8.348 ± 0.405 nM for an …

Immunotherapy In Hepatocellular Cancer Patients With Mild To Severe Liver Dysfunction: Adjunctive Role Of The Albi Grade, David J Pinato, Takahiro Kaneko, Anwaar Saeed, Tiziana Pressiani, Ahmed Kaseb, Yinghong Wang, David Szafron, Tomi Jun, Sirish Dharmapuri, Abdul Rafeh Naqash, Mahvish Muzaffar, Musharraf Navaid, Chieh-Ju Lee, Anushi Bulumulle, Bo Yu, Sonal Paul, Neil Nimkar, Dominik Bettinger, Hannah Hildebrand, Yehia I Abugabal, Celina Ang, Thomas U Marron, Uqba Khan, Nicola Personeni, Lorenza Rimassa, Yi-Hsiang Huang

Faculty, Staff and Students Publications

Immune checkpoint inhibitors (ICI) have shown positive results in patients with hepatocellular carcinoma (HCC). As liver function contributes to prognosis, its precise assessment is necessary for the safe prescribing and clinical development of ICI in HCC. We tested the accuracy of the albumin-bilirubin (ALBI) grade as an alternative prognostic biomarker to the Child-Turcotte-Pugh (CTP). In a prospectively maintained multi-centre dataset of HCC patients, we assessed safety and efficacy of ICI across varying levels of liver dysfunction described by CTP (A to C) and ALBI grade and evaluated uni- and multi-variable predictors of overall (OS) and post-immunotherapy survival (PIOS). We studied …

Inhibition Of Hdac1/2 Along With Trap1 Causes Synthetic Lethality In Glioblastoma Model Systems, Trang T. T. Nguyen, Yiru Zhang, Enyuan Shang, Chang Shu, Catarina M. Quinzii, Mike-Andrew Westhoff, Georg Karpel-Massler, Markus D. Siegelin

Publications and Research

The heterogeneity of glioblastomas, the most common primary malignant brain tumor, remains a significant challenge for the treatment of these devastating tumors. Therefore, novel combination treatments are warranted. Here, we showed that the combined inhibition of TRAP1 by gamitrinib and histone deacetylases (HDAC1/HDAC2) through romidepsin or panobinostat caused synergistic growth reduction of established and patient-derived xenograft (PDX) glioblastoma cells. This was accompanied by enhanced cell death with features of apoptosis and activation of caspases. The combination treatment modulated the levels of pro- and anti-apoptotic Bcl-2 family members, including BIM and Noxa, Mcl-1, Bcl-2 and Bcl-xL. Silencing of Noxa, BAK and …

Calculating An Equation To Estimate The Maximum Oxygen Uptake In Lifeguards, Brais Ruibal-Lista, José Palacios-Aguilar, José Antonio Prieto, Sergio López-García, Miguel Santiago-Alonso, José Antonio Cecchini-Estrada, Cristian Abelairas-Gómez

International Journal of Aquatic Research and Education

The aim of this study was to derive an equation that validly and reliably estimates the VO₂ reached in the IPTL, a maximum stress test for lifeguards. From the results obtained in the first part of the research, a multiple linear regression model was identified. A "stepwise" procedure was established as a variable selection method, where the VO_2IPTL was selected as the dependent variable and the maximum time reached in the IPTL (s), the percentage of muscle mass (%) and weight of the participant (kg), as independent variables. This procedure generated a regression model where a high correlation …

What Do Children Need From Playwork In The Time Of Covid-19? A Reflection On Playwork Practice In A Pandemic., Freya H. Howard

International Journal of Playwork Practice

This article explores the child’s need for play especially at the time of the coronavirus (COVID-19) pandemic in terms of the child’s welfare and rights, playfulness and their wellbeing. It reflects on previously learnt lessons with regards to virus outbreaks and the production of activity packs as a means of playwork in the pandemic context.

Antipsychotic Treatment Experiences Of People With Bipolar I Disorder: Patient Perspectives From An Online Survey, Martha Sajatovic

Faculty Scholarship

Background: Oral antipsychotic (AP) medications are frequently prescribed to people with bipolar I disorder (BD-I). A cross-sectional online survey examined the experiences of people living with BD-I with a history of recent AP use. Methods: Adults with self-reported physician-diagnosed BD-I (N = 200) who received oral APs during the prior year completed a survey on AP-related experiences, including side effects and their perceived burden on social functioning, adherence, and work. Items also assessed preferences for trade-offs (balancing symptom management and side effects) when considering a hypothetical new AP. The perceived impact of specific, prevalent side effects on adherence, work, and …

A Study On Ecological Distribution Of And Selected Gene Expression In Amblyomma Americanum: An Insight Into The Alpha-Galactose Allergy Caused By Tick Bites, Leah Cuthill

Electronic Theses & Dissertations

Ticks transmit a wide variety of pathogens including viruses, bacteria, protozoa, and helminthes to vertebrates. Their life cycle depends on blood meals from various hosts as well as on environmental conditions such as the temperature and habitat type. A newly recognized allergic disease has been identified and is characterized by a delayed reaction following the consumption of some mammalian meats. The allergy often results in life threatening reactions such as anaphylaxis, hives, and breathing problems 3-6 hours after the consumption of mammalian meat. Not everyone develops the allergy when they are bitten by a lone star tick, and the cause …

Fall Teaching And Learning Information, July 10, 2020, University Of Northern Iowa

UNI Response to COVID-19

A memo from Provost Wohlpart to faculty providing guidance as of July 1st on the conduct of teaching and learning for the Fall 2020 semester.

A Study Of Covid-19 Mortality Under Varying Patient Frailty, Alison N. Sifuentes

Theses and Dissertations

Modeled the spread and mortality of COVID-19 throughout the city of Chicago. By incorporating group frailty into a classic SEIR infectious disease model, we were able to differentiate the population of Chicago by their response to COVID-19. Three age groups with different COVID-19-induced death rates were examined, and the model sought to showcase the multiplicative deviation of each age group death rate from the average disease-induced death rate. This adjustment for different death rates among age groups accounted for heterogeneity within the population, and sought to introduce a more accurate manner for modeling the spread of infectious diseases.

Cholera In Present-Day Haiti: Interpretations Of And Responses To A Contemporary Enemy, Melissa Frick

Swarthmore Undergraduate History Journal

Note: In lieu of an abstract, this is the article's first paragraph.

"In his introduction to Epidemics and Ideas, Paul Slack calls to revive the study of social history of epidemics, wanting to show how societies cope with, react to, and interpret crises of disease. He reviews historian Richard Evans’ notion of the “common dramaturgy” to all epidemics, which states that human society responds to mass infection through an inherent response mechanism. Disease presents common dilemmas - including decisions on how the disease is transmitted, whom it infects, who is to blame, and incites common responses. Furthermore, Slack suggests that …

Positive Women: Emotion, Memory, And The Power Of Narrative In Women Organized To Respond To Life-Threatening Diseases, 1991-2020, Eleanor Naiman

Swarthmore Undergraduate History Journal

Note: In lieu of an abstract, this is the article's first paragraph.

"By 1992, the AIDS epidemic in the United States had reached seemingly catastrophic proportions. Over ten years after the first published report of AIDS-related lung infection, the number of AIDS cases in the United States far exceeded 100,000. It would be four years until the FDA approval of the first protease inhibitor. Over ten thousand women had been diagnosed with the disease, and experts expected over ninety thousand more were already infected. The disease, lacking effective treatment, increasingly struck women and people of color in the early 1990s; …