Medicine and Health Sciences Commons^™

Empowering Caregivers, Protecting Patients: An Ambulatory Central Line Quality Improvement Initiative For Education And Follow-Up, Elizabeth Martinez, Belinda Bordeaux, Stephanie Langevin, Cristina Herrera, Mary Smith, Merissa Doyle, Barbara Stein, Kimberly Poshar, Marissa Dunlap, Allison Silva, Eric Werner

Department of Pediatrics Faculty Publications

Introduction: Preventing ambulatory central line-associated bloodstream infections (A-CLABSIs) is challenging due to inconsistent education, follow-up, and home care practices. Pediatric intestinal failure (IF) patients are particularly vulnerable. This institution aimed to decrease its IF A-CLABSI rate by 25% within 2 years through a standardized, step-by-step central line care education program.

Methods: Using the Toyota problem-solving method, the team reviewed data and performed a root cause analysis of the prioritized problem, implementing a 2-phase education program. Phase 1 delivered in-hospital education using videos, handouts, and hands-on teaching with skill demonstration. The existing pediatric central line skills class was expanded and offered …

Type 2-Low Asthma: Epidemiology, Multiomics, And Emerging Therapies, Philip Mendez, Alanis Rosado, Juan Carlos Cardet

Department of Pediatrics Faculty Publications

Purpose of Review

Type 2-low (T2-low) asthma, characterized by low blood and sputum eosinophils and low fractional exhaled nitric oxide (FeNO), remains a major unmet need because of frequent corticosteroid insensitivity and a lack of targeted therapies. This review summarizes recent advances in its epidemiology, multiomics, and therapeutic landscape.

Recent findings

T2-low inflammation is highly prevalent, affecting approximately 14%-39% of adults with current asthma and up to 60% of children. Its pathogenesis reflects complex non-T2 mechanisms, including IL-17 signaling, innate immune activation through IL-1β and IL-33, and neutrophilic inflammation. Heterogeneity is further shaped by systemic factors such as obesity and …

Impact Of Exercise And Cognitive Behavioral Therapy On Anxiety And Depression, Ranjita Subedi, Rachel Affeldt, Abigail Bentley, Gavin Gump, Madison Mitchell, Taylor Rodgers, Bayley Mullins, Libbie Woodland, Sophia Rubenkoenig

Nurse Residency Posters

OhioHealth Grant Medical Center

Impact Of Fast Track On Emergency Department Length Of Stay, Kayce Carrick Bsn, Rn, Kelsey Richmond Rn, Stacy Duncan Rn

Nurse Residency Posters

Facilitator: Melissa Harper, BSN, RN

OhioHealth O'Bleness Hospital

Impact Of Intentional Leadership Styles On Staff Nurse Satisfaction And Retention, Monica Patrick Rn, Camie Mitchell Rn, Amelia Kennedy Rn, Rachel Geiger Rn, Zachary Foster Rn, Katherine Leahy Rn

Nurse Residency Posters

Facilitator: Tess Wagner, BSN, RN

OhioHealth Riverside Methodist Hospital

Quantifying Hemodynamics In Implantable Cardiac And Renal Support Devices Using Computational Modeling, Alexander D. De Oliveira

Summer Research Program Abstracts

No abstract provided.

Reference-Point Indentation Captures Age-Related Material-Quality Changes In Human Infant Rib Cortical Bone, Kush Patel

Summer Research Program Abstracts

No abstract provided.

Reducing No-Show Rates In A Rural Family Medicine Clinic Through Personal Phone Call Reminders, Joyce Bumgardner

Doctor of Nursing Practice Projects

Background: Missed patient appointments cost the healthcare industry billions annually, reducing provider accessibility and practice revenue. At a rural family medicine office in western Lincoln County, North Carolina, new patient no-show rates exceeded 10%, surpassing the healthcare system’s goal of 5% or less. Automated appointment reminders via text, phone, and email were already in place, but did not adequately address the problem. New patient appointments occupy a 40-minute time slot, twice that of established patients, increasing the impact of each missed appointment.

Purpose: The purpose of this quality improvement project was to determine whether personal phone call reminders made with …

Gratitude Journaling And Mindfulness To Mitigate Burnout In Mental Health Staff, Jennifer Davis

Doctor of Nursing Practice Projects

Burnout among mental health professionals in inpatient behavioral health settings negatively affects staff well-being, job satisfaction, and patient care quality. This Doctor of Nursing Practice (DNP) quality improvement project evaluated the effectiveness of an 8-week mindfulness and gratitude journaling program implemented on a rural behavioral health unit in North Carolina. Guided by Jean Watson’s Theory of Human Caring, the intervention aimed to enhance resilience and workplace wellness through daily mindfulness and reflective journaling practices. A repeated cross-sectional design using anonymous pre- and post-intervention surveys was conducted with 30 staff participants. Thirty participants enrolled in the study, and 24 completed the …

Hands-Free Tech For Fall Prevention, Sierra Dixon Rn, Jessica Gillam Rn, Bryan Hatheway Rn, Taightam Hicks Bsn, Rn, Kelsey Tignor Bsn, Rn, Hailie Tomsik Rn, Jeremiah Waworoendeng Rn

Nurse Residency Posters

Facilitator: Kasey Gillen, MHA, BSN, RN, NPD-BC

OhioHealth Mansfield Hospital

Estrogen Deprivation During Primate (Papio Anubis) Pregnancy: Impact On Systemic Microvascular Flow And Cardiovascular Development And Function After Birth In Offspring, Sifa Turan, Jeffery S. Babischkin, Graham W. Aberdeen, Gerald J. Pepe, Eugene D. Albrecht

Department of Biomedical and Translational Sciences Faculty Publications

Background

Suppressing estradiol (E₂) during baboon pregnancy lowers offspring skeletal muscle capillary density, vital for insulin-mediated glucose uptake, and induces insulin resistance. We examined whether E₂ deprivation also impairs microvascular flow and cardiac function.

Methods

Offspring of untreated baboons, letrozole-treated baboons, or letrozole plus E₂ (maternal s.c. injections during the second half of gestation) underwent contrast-enhanced microbubble ultrasonography to quantify microvessel flow and echocardiography to assess cardiac performance.

Results

Letrozole reduced maternal serum E₂ by 95% (p <  0.01). In letrozole offspring, microbubble flux rate (β) fell 55% (p <  0.02), replenishment was 5 s slower (p <  0.03), and microvessel flow declined 40% (p = 0.05); all were restored by added E₂. Indices of systolic (isovolumic contraction), diastolic (isovolumic relaxation), global performance (Tei index), and cardiac output were unchanged.

Conclusion

Prolonged gestational E₂ deprivation programs a reduction in microvascular flow without altering cardiac function; maternal E₂ prevents this, supporting E₂'s role in …

Educational Case: Atypical Presentation Of Primary Hyperparathyroidism With Brown Tumor, Ariel Flotte, Jonathan Light, Harrison Klause, Richard M. Conran

Department of Biomedical and Translational Sciences Faculty Publications

The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology.

Yk-4-250 Mitigates Gastrointestinal Radiation Syndrome And Promotes Overall Survival Following Partial Body Radiation Injury, Vidya P. Kumar, Yali Kong, Kan Wang, Asa R. Britton-Jenkins, Stanton Dulan, Landon L. Moore, Debra Saunders, Randal May, Rheal Towner, Sanchita P. Ghosh, Courtney W. Houchen, Milton L. Brown

Department of Biomedical and Translational Sciences Faculty Publications

Acute gastrointestinal radiation syndrome (GI-ARS) is a significant health threat following high-dose ionizing radiation (IR) exposure, leading to severe morbidity and mortality. The syndrome is characterized by gastrointestinal tissue damage caused by angiotensin II (Ang II) and reactive oxygen species (ROS), resulting in impaired GI function, systemic bacteremia, multi-organ failure, and eventual death. Dysregulation of the renin-angiotensin system (RAS) via Ang II exacerbates ROS production through activation of the Angiotensin II type 1 receptor (AT1R). This underscores the need for agents capable of both scavenging ROS and inhibiting AT1R activity. To address this, we developed YK-4-250, a Tempol-conjugated angiotensin receptor …

Expert Consensus On Osteoporosis Risk Management In Patients With Sleep Disorders, Siqi Leng, Jinming Yang, Yuming Jin, Jie Shi, Ye Zhang, Junying Zhou, Lusi Tan, Taomei Li, Peiyan Ni, Kejia Hu, Yuan Shi, Jiamin Liao, Yun Li, Pei Xue, Christian Benedict, Alexandros N. Vgontzas, Michael Furian, Talant Sooronbaev, Naima Covassin, Virend K. Somers, Zhoulong Yu, Hongqiang Sun, Xiao Tan, Jihui Zhang, Yun Kwok Wing, Yue Leng, Larry D. Sanford, Michael V. Vitiello, Katie L. Stone, Rong Ren, Lin Lu, Xiangdong Tang

Department of Biomedical and Translational Sciences Faculty Publications

A rate-limiting step in the prevention and early intervention of osteoporosis is identifying its asymptomatic onset. Accumulating evidence shows that sleep disorders are associated with an increased risk of osteoporosis. Given their early detectable and modifiable nature, integrating sleep disorder management into osteoporosis prevention and care pathways offers a novel approach for enhancing skeletal health. This expert consensus represents a collaborative effort by specialists in sleep medicine and orthopedics from across the world, integrating epidemiological, mechanistic, and interventional evidence to provide general guidance for prevention and clinical practice, and to foster multidisciplinary collaboration in the management of sleep disorders and …

Revised Microbiology Core Knowledge Objectives For Modern Undergraduate Medical Education, Timothy J. Bauler, Cindy G. Arvidson, Samina Akbar, Dennis N. Arvidson, Margaret E. Bauer, Dwayne M. Baxa, Rebecca J. Greenblatt, Kerstin Honer Zu Bentrup, Yingguang Liu, Inaia Phoenix, Julie A. Kerry

Department of Biomedical and Translational Sciences Faculty Publications

Defining the core content for each scientific discipline in a modern preclinical medical education curriculum is critical to ensure optimal student learning and application of foundational knowledge for clinical practice. Attendees of the Association of Medical School Microbiology and Immunology Chairs (AMSMIC) Educational Strategies Workshop recently highlighted the need for updated medical microbiology learning objectives, given the shift in medical education toward less time for preclinical coursework and more integrated learning. Herein, we describe the process of developing a comprehensive, educator-driven set of knowledge objectives for medical microbiology. These objectives emphasize common pathogens, as well as pathogens associated with severe …

Regulation Creations: A Trauma-Informed Resource Addressing Sensory And Socio-Emotional Childhood Challenges, Meagan Noel Barnes Pearson

Occupational Therapy Capstones

Introduction: Trauma is ubiquitous and can negatively impact many life outcomes. Though trauma can occur across the lifespan, particular emphasis has been placed on the outcomes of experiences that occur in childhood. Adverse childhood experiences (ACEs), as coined by Felitti et al. (1998), pertain to traumatic events that occur before the age of 18, and the correlation between the number of ACEs and poor health outcomes is significant. Children can begin demonstrating unfavorable symptoms upon becoming exposed to trauma. Current literature has illustrated particular differences in sensory systems and social skills for young children. These challenges can lead to hardship …

Changing Times: A New Approach To Assessing Functional Cognition Using Smartphone Navigation Tool In Acute Care Setting Case Report, Aubrey Schmidt Ms Otr/L, Csrs, Natalie Dispoto Otr/L, Tory Laubach Otr/L, Nicole Moyer Otr

Department of Medicine

No abstract provided.

Dermatology Skin Lesion Image Analysis, Victoria Wegley, Joshua Hoog, Tristan Crawford, Keith Miller, William Fons, K. Pugh, J. Taylor, S. Swinfard, A. Fernandes, G. Patel, J. Hagerty, W. V. Stoecker, Ronald Joe Stanley

Research Data

Dermatology skin lesion image analysis research has been ongoing at Missouri S&T (previously UMR) since the 1980s. Our group has been successful in finding over 20 key dermoscopic structures in melanoma, melanoma mimics, and nonmelanoma skin cancers using iterative structure-based analysis. Structures are chosen to reduce system errors which are concentrated in a few classes: amelanotic/featureless, regressed, and small in situ melanomas, and the most difficult benign lesions to identify: Clark nevi, lentigines, and seborrheic keratoses [1]. Preliminary research detecting and using annotated lesion structures [2-7] and lesion artifacts [8,9] guided by clinical experience [10] with image processing and deep …

Health Communication Challenges In The Digital Era: Two Empirical Investigations, Neeraj Gautam Patel

Yale Medicine Thesis Digital Library

Background: The quality and availability of health information consumed by the general public have undergone dramatic changes in the 21st century with the rise of digitization and the internet. These include the growth of direct-to-consumer (DTC) advertising of prescription drugs on television and online media, changes in health content on traditional news media platforms, and the propagation of health misinformation and disinformation on social media and other websites. Understanding the nature and sources of these changes can inform efforts and interventions aimed at improving the general public’s understanding of health information. One area of interest within regulated health communication is …

Oxytocin Dosing During Trial Of Labor After Cesarean To Minimize The Risk Of Uterine Rupture: A Systematic Review And Meta-Analysis, Pierpaolo Nicolì, Moti Gulersen, Jordan Beacham, Hila Hochler, Alessandra Familiari, Anna Locatelli, Cynthia Abraham, Ettore Cicinelli, Amerigo Vitagliano, Vincenzo Berghella

Department of Obstetrics and Gynecology Faculty Papers

OBJECTIVE: Oxytocin remains the mainstay for induction and for the management of labor arrest during trial of labor after cesarean (TOLAC). Therefore, the clinical question should be not whether to use oxytocin, but how to optimize its administration. This meta-analysis aimed to assess which oxytocin protocol, in terms of initial dose, amount of increase, timing to next increase, and maximum dose, may minimize the risk of uterine rupture (UR) during TOLAC.

DATA SOURCES: PubMed, Embase and Clinicaltrials.gov were searched up to September 21, 2024.

STUDY ELIGIBILITY CRITERIA: Randomized and nonrandomized studies evaluating the association between induction and/or augmentation with oxytocin …

Impact Of Prophylactic Oral Azithromycin During Labor On Azithromycin Resistance (Amr) In Nasal Staphylococcus Aureus And Streptococcus Pneumoniae In Women And Infants In The Multi-Country Azithromycin Prevention In Labor Use Study (A-Plus)., Patricia L. Hibberd, Jean H. Kim, Marissa Trotta, Sixto M. Leal, Anna Aceituno, Doyle V. Ward, Archana Patel, Akila Subramaniam, Waldemar A. Carlo, Imran Ahmed, Sarah Saleem, Sk Masum Billah, Rashidun Haque, Manolo Mazariegos, Fabian Esamai, Manjunath S. Somannavar, Shivaprasad S. Goudar, Elwyn Chomba, Muska Mwenchanya, Adrien Lokangaka, Antoinette Tshefu, Robert L. Goldenberg, Melissa Bauserman, Nancy F. Krebs, Sherri Bucher, Richard J. Derman, William A. Petri, Marion Koso-Thomas, Denise C. Babineau, Elizabeth M. Mcclure, Alan T. N. Tita

Department of Obstetrics and Gynecology Faculty Papers

BACKGROUND: Prophylactic oral azithromycin vs. placebo reduced maternal, but not neonatal, mortality/sepsis in the A-PLUS Randomized Trial. While prophylactic intrapartum azithromycin reduces maternal mortality/sepsis, it may promote antimicrobial resistance (AMR) in commensal bacteria,.

METHODS: Randomly selected women and their infants participating in A-PLUS were enrolled in a longitudinal cross-sectional sub-study to assess the presence of azithromycin resistance in selected bacteria in nasal cultures. Staphylococcus aureus and Streptococcus pneumoniae were cultured on selective agar, then azithromycin-containing agar to select for azithromycin resistant bacteria, identified biochemically. Azithromycin susceptibility was assessed by E-test. Nasal cultures were collected from women and infants between August …

Intermittent Androgen Deprivation Therapy For Biochemical Recurrence Or Prostate-Specific Antigen (Psa) Persistence After Radical Prostatectomy: Efficacy And Prognostic Factors, Jian Chen, Qiming Chen, Xuzhi Yan, Ziqian Wang, Yapeng Wang, Yao Zhang, Jun Zhang, Jing Xu, Junying Zhang, Dianzheng Zhang, Qiuli Liu, Wuihua Lan, Jun Jiang

PCOM Scholarly Works

Background: The optimal protocol for intermittent androgen deprivation therapy (IAD) in managing biochemical recurrence (BCR) and persistent prostate-specific antigen (PSA) levels after radical prostatectomy (RP) remains undefined. This study aimed to introduce a novel IAD protocol, conduct an initial assessment of the protocol’s effectiveness in real-world settings, and develop a risk-based model to identify patients most likely to benefit from this approach. Methods: This study included 175 post-RP patients receiving IAD, with a median follow-up of 44.77 months [interquartile range (IQR), 31.87–69.50 months] post-androgen deprivation therapy (ADT). The IAD protocol used a PSA threshold of 0.2 ng/mL to define progression …

Therapeutic Landscape Of Early Symptomatic Alzheimer's Disease Translated Into Everyday Practice For Geriatric Providers., Melissa J Bailey-Taylor, Paula Morrow, James Hendrix, Katherine E. Galluzzi, Golnosh Sharafsaleh

PCOM Scholarly Works

Alzheimer's disease (AD) accounts for 60-80% of all dementia cases. Recent advances in diagnostic biomarkers of early symptomatic AD (ie, mild cognitive impairment and mild dementia due to AD) and amyloid-targeting therapies (ATTs) have the potential to improve outcomes for patients with AD. Two ATTs (donanemab and lecanemab) are currently approved and available for use in the US. Both ATTs can slow disease progression as well as cognitive and functional decline in patients with early symptomatic AD. Treatment with ATTs is associated with specific safety concerns such as amyloid-related imaging abnormalities. Therefore, the benefit versus risk profile needs to be …

Exposition Professionnelle Aux Agents D'Infections Nosocomiales En Milieux De Soins : Mieux Comprendre Et Contrôler La Voie De Propagation Par Aérosols, Caroline Duchaine, Yves Longtin, Marc Veillette, Adriana Larotta, Bianka Paquet Bolduc

Rapports de recherche scientifique

Ce projet, mené dans le contexte de la pandémie de COVID-19, visait à mieux comprendre les risques liés à la présence de virus et de bactéries dans l’air des milieux de soins et à identifier les meilleures façons de protéger le personnel de la santé. Ce projet s’est articulé autour de trois grands volets de recherche complémentaires, menés en milieux réels et en laboratoire. Le premier volet visait à documenter la présence de virus comme le SARS-CoV-2 (responsable de la COVID-19), l’influenza ou le norovirus dans l’air d’hôpitaux et de centres de soins de longue durée. Des prélèvements dans les …

Effets Respiratoires De L'Exposition Journalière Aux Particules Respirables, Fines Et Ultrafines Dans Divers Milieux De Travail, Audrey Smargiassi, Maximilien Debia, Eva Suarthana

Rapports de recherche scientifique

De très nombreux travailleurs sont exposés quotidiennement à des niveaux de particules dans l’air ambiant qui dépassent largement les concentrations auxquelles la population générale est exposée. Néanmoins, très peu d’études ont porté sur l’influence de l’exposition quotidienne des travailleurs aux particules respirables sur la santé respiratoire. La majorité des études se sont intéressées aux effets des expositions prolongées sur le développement de maladies respiratoires. Pourtant, les associations entre l’exposition journalière aux particules respirables et l’inflammation pulmonaire et la fonction respiratoire sont bien documentées pour la population générale. Les effets des particules respirables pourraient différer pour les travailleurs parce que les …

Green Modification Of A Coupling Reaction Between N-Acetylated Amino Acids And P-Nitrothiophenol, Kaitlyn S. Marley, Hannah M. Werle, John P. Morgan

SURF Posters 2026

Native Chemical Ligation (NCL) is a process by which smaller peptides can be linked together to form larger peptides and proteins, but the preparation of necessary thioester starting materials often relies on hazardous reagents. We report a greener synthesis of S-(4- nitrophenyl) N-acetylphenylalaninethioate, building upon the methodology reported by Raines et al.1 This literature synthesis uses N,N-dimethylformamide (DMF) as solvent in the final thioester coupling step to accommodate the limited solubility of N-acetylphenylalanine in less polar solvents. However, DMF is a known reproductive toxin and environmental hazard. Our research demonstrates that acidic water serves as a highly effective, benign alternative …

Distinct Glycosyltransferase Expression Governs Organ-Specific Survival In Pancreatic Cancer Metastasis, Venkatesh Varadharaj, Frank Leon, Nivedeta Krishna Kumar, Palanisamy Nallasamy, Pratima Raut, Annant Bir Kaur, Kirtana Arikath, Wyatt Petersen, Sanchita Rauth, Neelanjana Gayen, Zahraa Wajih Alsafwani, Poompozhil Mathivanan, Saravanakumar Marimuthu, Kavita Mallya, Madhu Bommideni, Jesse L. Cox, G. Talmon, Paul M. Grandgenett, Michael A. Hollingsworth, Dominick J. Dimaio, Jean L. Grem, Surinder K. Batra, Moorthy P. Ponnusamy

Journal Articles: Biochemistry & Molecular Biology

Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal cancers, with over 83% of patients presenting metastases to vital organs such as the liver, lungs, and peritoneum. Although glycosylation has been established as a critical factor in PDAC development, little is known about the molecular underpinnings of organ-specific metastasis. In this study, we investigated the role of glycosyltransferases (GTs) in mediating PDAC metastatic organotropism. Through an unbiased transcriptomic screen, we identified distinct GT expression patterns in liver- and lung-tropic PDAC cells. Notably, GCNT3 and B3GNT3 were selectively upregulated in liver and lung-tropic cells, respectively. These mutually exclusive expression patterns were …

Simulation Scenario Builder, Jami Monico

Instructional Materials: Graduate Medical Education

Simulation Scenario Builder is a structured Excel‑based tool designed to guide educators through the complete development of clinical simulation experiences. Organized according to the Healthcare Simulation Standards of Best Practice™, this builder ensures consistency, quality, and standardization when creating simulation activities for learners in health professions education. The file includes linked resources, fillable planning sections, and templates for scenario design, prebriefing, debriefing, learner preparation, assessment, fidelity planning, and evaluation.

Navigating Academic Demands In Higher Education After Mild Traumatic Brain Injury, Abigail Mosteller, Chitrali R. Mamlekar

SURF Posters 2026

Although, mild traumatic brain injuries (mTBI) are classified as mild; their consequences can be substantial. These injuries can result in significant cognitive, physical, and emotional symptoms. While many individuals recover within a few weeks, others experience persisting symptoms such as headaches, dizziness, fatigue, brain fog, difficulties with attention and memory. For college students, these ongoing symptoms can significantly interfere with academic participation and success, impairments in communication, executive functioning, processing speed, memory, or attention may make it difficult to follow lectures, complete assignments, meet deadlines and study effectively. Universities may offer accommodations and academic support services; however, the availability of …

Real-Time Electronic Drug Monitoring: Experiences From A Multinational Phase 3 Clinical Trial To Prevent Multidrug-Resistant Tb, T. Jimah, J.E. Haberer, K.R. Amico, J. Tinkamanyire, M.A. Kendall, S. Moonsamy, R.T. Khan, K.B.F. Fetalvero, N. Suryavanshi, A. Gupta, A.C. Hesseling, Susan Swindells, G. Churchyard

Journal Articles: Infectious Diseases

OBJECTIVE: We describe the experience of implementing real-time electronic drug monitoring (EDM) within a clinical trial to prevent multidrug-resistant TB (MDR-TB) among high-risk household contacts.

METHODS: The Protecting Households On Exposure to Newly Diagnosed Index Multidrug-Resistant Tuberculosis Patients (PHOENIx) trial is a phase 3, open-label, cluster-randomised clinical trial conducted in 31 sites in Africa, Asia, and Latin America. Household contacts of adults with MDR-TB were enrolled from June 2019 to January 2025, each receiving an EDM device to monitor adherence to TB preventive therapy. Here, we review selection of the adherence monitoring approach and key procedures implemented to support EDM …