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Articles 148471 - 148500 of 328356
Full-Text Articles in Medicine and Health Sciences
Adad1 And Adad2, Testis-Specific Adenosine Deaminase Domain-Containing Proteins, Are Required For Male Fertility., Elizabeth Snyder, Lauren Chukrallah, Kelly Seltzer, Leslie Goodwin, Robert E Braun
Adad1 And Adad2, Testis-Specific Adenosine Deaminase Domain-Containing Proteins, Are Required For Male Fertility., Elizabeth Snyder, Lauren Chukrallah, Kelly Seltzer, Leslie Goodwin, Robert E Braun
Faculty Research 2020
Adenosine-to-inosine RNA editing, a fundamental RNA modification, is regulated by adenosine deaminase (AD) domain containing proteins. Within the testis, RNA editing is catalyzed by ADARB1 and is regulated in a cell-type dependent manner. This study examined the role of two testis-specific AD domain proteins, ADAD1 and ADAD2, on testis RNA editing and male germ cell differentiation. ADAD1, previously shown to localize to round spermatids, and ADAD2 had distinct localization patterns with ADAD2 expressed predominantly in mid- to late-pachytene spermatocytes suggesting a role for both in meiotic and post-meiotic germ cell RNA editing. AD domain analysis showed the AD domain of …
2020-07-14_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services
2020-07-14_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services
Michigan COVID-19 Long Term Care Data
The COVID Long Term Care Facilities page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173-526911--,00.html.
This report is created by the Michigan Department of Health & Human Services from data self-reported by long-term care facilities into EMResource. Data is updated on an ongoing basis.
The data below represents a cumulative total of confirmed COVID-19 resident cases, cumulative total of suspected and confirmed resident deaths, cumulative total of confirmed COVID-19 staff cases, and cumulative total of suspected and confirmed staff deaths reported by SNFs in Michigan since January 1, 2020. Case numbers are provisional and may change as facilities correct …
2020-07-14_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services
2020-07-14_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services
Cumulative Michigan COVID-19 Data
The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.
This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) and rapid virus antigen detection point of care (POC) tests, look for current infection. Serology (antibody) tests are used to look for the possibility of previous infection.
Source: Michigan Disease Surveillance System (MDSS) and Vital Records
The website contained the tables …
2020-07-14_Michigandaily_Covidmap, Michigan Department Of Health & Human Services
2020-07-14_Michigandaily_Covidmap, Michigan Department Of Health & Human Services
Daily Michigan COVID-19 Update
The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.
The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.
The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …
Impact Of Covi0-19 On Mental Health And Quality Of Life In The Mena Region: A Cross-Sectional Study (Issue 18, 14 July 2020), Liliana Stojanovska, Habiba Ali, Amjad Jarrar, Amina Mohammed Almarzouqi, Reyad Rashid Obaid, Tareq Osaili, Hayder A. Hasan, Maysm N. Mohamad, Mona Hashim, Abir Ajab, Sheima Saleh, Mo'ath Bataineh, Carla Habib Mourad, Samar Elfeky, Osama Arafa Elhameed
Impact Of Covi0-19 On Mental Health And Quality Of Life In The Mena Region: A Cross-Sectional Study (Issue 18, 14 July 2020), Liliana Stojanovska, Habiba Ali, Amjad Jarrar, Amina Mohammed Almarzouqi, Reyad Rashid Obaid, Tareq Osaili, Hayder A. Hasan, Maysm N. Mohamad, Mona Hashim, Abir Ajab, Sheima Saleh, Mo'ath Bataineh, Carla Habib Mourad, Samar Elfeky, Osama Arafa Elhameed
Covid19 Newsletters
No abstract provided.
Repeatedly Heated Mix Vegetable Oils-Induced Atherosclerosis And Effects Of Murraya Koenigii, Gul Ambreen, Afshan Siddiq, Kashif Hussain, Abdul Saboor Hussain, Zara Naz
Repeatedly Heated Mix Vegetable Oils-Induced Atherosclerosis And Effects Of Murraya Koenigii, Gul Ambreen, Afshan Siddiq, Kashif Hussain, Abdul Saboor Hussain, Zara Naz
Department of Biological & Biomedical Sciences
Background: Statins are considered as standard drugs to control cholesterol levels, but their use is also associated with renal hypertrophy, hemorrhagic stroke, hepatomegaly, and myopathy. Murraya koenigii is an herb that is used in traditional cuisine and as a medicine in South Asia. Here we assessed the antidyslipidemic and antiatherosclerotic effects of this spice in repeated heated mix vegetable oils (RHMVO)-induced atherosclerotic models.
Methods: Aqueous extract of M. koenigii leaves (Mk LE) was prepared and its phytoconstituents were determined. Rabbits were divided into 5 groups (n = 10). Except for the control group, all the other four groups were treated …
Meta-Analysis Of The Alzheimer's Disease Human Brain Transcriptome And Functional Dissection In Mouse Models., Ying-Wooi Wan, Rami Al-Ouran, Carl G Mangleburg, Thanneer M Perumal, Tom V Lee, Katherine Allison, Vivek Swarup, Cory C Funk, Chris Gaiteri, Mariet Allen, Minghui Wang, Sarah M Neuner, Catherine C Kaczorowski, Vivek M Philip, Gareth R Howell, Heidi Martini-Stoica, Hui Zheng, Hongkang Mei, Xiaoyan Zhong, Jungwoo Wren Kim, Valina L Dawson, Ted M Dawson, Ping-Chieh Pao, Li-Huei Tsai, Jean-Vianney Haure-Mirande, Michelle E Ehrlich, Paramita Chakrabarty, Yona Levites, Xue Wang, Eric B Dammer, Gyan Srivastava, Sumit Mukherjee, Solveig K Sieberts, Larsson Omberg, Kristen D Dang, James A Eddy, Phil Snyder, Yooree Chae, Sandeep Amberkar, Wenbin Wei, Winston Hide, Christoph Preuss, Ayla Ergun, Phillip J Ebert, David C Airey, Sara Mostafavi, Lei Yu, Hans-Ulrich Klein, Accelerating Medicines Partnership, Alzheimer’S Disease Consortium, Gregory W Carter, David A Collier, Todd E Golde, Allan I Levey, David A Bennett, Karol Estrada, T Matthew Townsend, Bin Zhang, Eric Schadt, Philip L De Jager, Nathan D Price, Nilüfer Ertekin-Taner, Zhandong Liu, Joshua M Shulman, Lara M Mangravite, Benjamin A Logsdon
Meta-Analysis Of The Alzheimer's Disease Human Brain Transcriptome And Functional Dissection In Mouse Models., Ying-Wooi Wan, Rami Al-Ouran, Carl G Mangleburg, Thanneer M Perumal, Tom V Lee, Katherine Allison, Vivek Swarup, Cory C Funk, Chris Gaiteri, Mariet Allen, Minghui Wang, Sarah M Neuner, Catherine C Kaczorowski, Vivek M Philip, Gareth R Howell, Heidi Martini-Stoica, Hui Zheng, Hongkang Mei, Xiaoyan Zhong, Jungwoo Wren Kim, Valina L Dawson, Ted M Dawson, Ping-Chieh Pao, Li-Huei Tsai, Jean-Vianney Haure-Mirande, Michelle E Ehrlich, Paramita Chakrabarty, Yona Levites, Xue Wang, Eric B Dammer, Gyan Srivastava, Sumit Mukherjee, Solveig K Sieberts, Larsson Omberg, Kristen D Dang, James A Eddy, Phil Snyder, Yooree Chae, Sandeep Amberkar, Wenbin Wei, Winston Hide, Christoph Preuss, Ayla Ergun, Phillip J Ebert, David C Airey, Sara Mostafavi, Lei Yu, Hans-Ulrich Klein, Accelerating Medicines Partnership, Alzheimer’S Disease Consortium, Gregory W Carter, David A Collier, Todd E Golde, Allan I Levey, David A Bennett, Karol Estrada, T Matthew Townsend, Bin Zhang, Eric Schadt, Philip L De Jager, Nathan D Price, Nilüfer Ertekin-Taner, Zhandong Liu, Joshua M Shulman, Lara M Mangravite, Benjamin A Logsdon
Articles, Abstracts, and Reports
We present a consensus atlas of the human brain transcriptome in Alzheimer's disease (AD), based on meta-analysis of differential gene expression in 2,114 postmortem samples. We discover 30 brain coexpression modules from seven regions as the major source of AD transcriptional perturbations. We next examine overlap with 251 brain differentially expressed gene sets from mouse models of AD and other neurodegenerative disorders. Human-mouse overlaps highlight responses to amyloid versus tau pathology and reveal age- and sex-dependent expression signatures for disease progression. Human coexpression modules enriched for neuronal and/or microglial genes broadly overlap with mouse models of AD, Huntington's disease, amyotrophic …
2020-07-14_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services
2020-07-14_Michiganoverview_Covidbedppe, Michigan Department Of Health & Human Services
Michigan COVID-19 Hospital Data
The webpage was obtained from Michigan's Coronavirus Cumulative Data page, under the link Data About Places. Data is self-reported by hospitals daily to the EM Resource System per MDHHS Director Robert Gordon's Emergency Order.
Contains the tables Statewide Available Bed Tracking for COVID-19, COVID-19 Metrics, Statewide Available PPE Tracking for COVID-19 (Statewide Available PPE and Bed Tracking), as well as the tables PPE Days On Hand and Patient Census.
Effect And Feasibility Of District Level Scale Up Of Maternal, Newborn And Child Health Interventions In Pakistan: A Quasi-Experimental Study, Zahid Memon, Shah Muhammad, Sajid Bashir Soofi, Nimra Khan, Nadia Akseer, Atif Habib, Zulfiqar Ahmed Bhutta
Effect And Feasibility Of District Level Scale Up Of Maternal, Newborn And Child Health Interventions In Pakistan: A Quasi-Experimental Study, Zahid Memon, Shah Muhammad, Sajid Bashir Soofi, Nimra Khan, Nadia Akseer, Atif Habib, Zulfiqar Ahmed Bhutta
Woman and Child Health
Introduction: Pakistan has a high burden of maternal, newborn and child morbidity and mortality. Several factors including weak scale-up of evidence-based interventions within the existing health system; lack of community awareness regarding health conditions; and poverty contribute to poor outcomes. Deaths and morbidity are largely preventable if a combination of community and facility-based interventions are rolled out at scale.
Methods and analysis: Umeed-e-Nau (UeN) (New Hope) project aims is to improve maternal, newborn and child health (MNCH) in eight high-burden districts of Pakistan by scaling up of evidence-based interventions. The project will assess interventions focused on, first, improving the quality …
Global Challenges Of Being A Strength Athlete During A Pandemic: Impacts And Sports-Specific Training Considerations And Recommendations, Christopher Latella, G. Gregory Haff
Global Challenges Of Being A Strength Athlete During A Pandemic: Impacts And Sports-Specific Training Considerations And Recommendations, Christopher Latella, G. Gregory Haff
Research outputs 2014 to 2021
The ongoing global pandemic brought about by Coronavirus II (SARS-Cov-2 or COVID-19) has caused an ongoing cessation of sporting competitions and training facility closures. This is a fundamental challenge for amateur and elite sporting professionals. Although recommendations have been provided for team-sport athletes to maintain general and sport-specific conditioning, these methods are often not optimal for strength athletes (i.e., powerlifting (PL) and weightlifting (WL)) due to the unique and narrow set of performance requirements posed by these sports. The purpose of this review is to provide evidence-based information and recommendations and highlight potential strategies and approaches that may be used …
Communication Training In Adult And Pediatric Critical Care Medicine. A Systematic Review, Michael P Mendez, Harin Patel, Jordan Talan, Michelle Doering, Jared Chiarchiaro, Rebecca M Sternschein, Trevor C Steinbach, Jacqueline O'Toole, Abdulghani Sankari, Jennifer W Mccallister, May M Lee, W Graham Carlos, Patrick G Lyons
Communication Training In Adult And Pediatric Critical Care Medicine. A Systematic Review, Michael P Mendez, Harin Patel, Jordan Talan, Michelle Doering, Jared Chiarchiaro, Rebecca M Sternschein, Trevor C Steinbach, Jacqueline O'Toole, Abdulghani Sankari, Jennifer W Mccallister, May M Lee, W Graham Carlos, Patrick G Lyons
2020-Current year OA Pubs
No abstract provided.
Week Of July 14, 2020, New York Medical College
Week Of July 14, 2020, New York Medical College
InTouch
- NYMC Announces Breakthrough Patent for Revolutionary New Bandage Using Nano Cells to Deliver Antimicrobials and Promote Healing
- NYMC Welcomes Neil W. Schluger, M.D., as the Barbara and William Rosenthal Chair of the Department of Medicine
- Join the HSL for a Community Read and Book Club
Comparative Whole-Genome And Phenotype Analyses Of Virulence Factors And Lethality In Nematode Challenge Assay Among Aeromonas Isolates, Pyeongsug Kim
Comparative Whole-Genome And Phenotype Analyses Of Virulence Factors And Lethality In Nematode Challenge Assay Among Aeromonas Isolates, Pyeongsug Kim
Master of Science in Integrative Biology Theses
Aeromonads are bacteria found globally in fresh and brackish waters, with some species causing water-borne diseases vertebrate hosts such as diarrhea and wound-infections in humans and motile Aeromonas septicemia in fish. Although many virulence factors have been described, determining which factors are most important in pathogenesis is ongoing. To examine this further, the genomes of five Aeromonas strains isolated from various animals were sequenced and annotated in this study. Each isolate was further characterized using comparative genomic analyses and testing for production of selected virulence factors. Although previously identified as Aeromonas hydrophila, modern genotypic approaches including multilocus sequence typing …
Employment And Patient Satisfaction After Liver Transplantation, Christopher Cao, Dina Halegoua-De Marzio, Shady Guirguis, Crystal Chen, Jonathan M. Fenkel, Steven Herrine
Employment And Patient Satisfaction After Liver Transplantation, Christopher Cao, Dina Halegoua-De Marzio, Shady Guirguis, Crystal Chen, Jonathan M. Fenkel, Steven Herrine
Division of Gastroenterology and Hepatology Faculty Papers
Background and Aims: This study serves to revisit the effects of liver transplantation (LT) on employment in an era of improving survival outcomes post-transplant, and to identify areas of improvement in the transplant process to better op-timize post-LT employment and patient satisfaction. Methods: Prospectively, patients who had undergone LT at a single tertiary LT center were surveyed in person and by e-mail. Primary outcomes included employment rate pre-and post-LT, annual salary, weekly hours worked, barriers to re-employment, and patient satisfaction. Results: Responses were collected and analyzed from 121 patients who underwent LT. Pre-LT, 68 (56.1%) reported full-time employ-ment, 13 (10.7%) …
Automatic Recognition, Segmentation, And Sex Assignment Of Nocturnal Asthmatic Coughs And Cough Epochs In Smartphone Audio Recordings: Observational Field Study, Filipe Barata, Peter Tinschert, Frank Rassouli, Claudia Steurer-Stey, Elgar Fleisch, Milo Puhan, Martin Brutsche, David Kotz, Tobias Kowatsch
Automatic Recognition, Segmentation, And Sex Assignment Of Nocturnal Asthmatic Coughs And Cough Epochs In Smartphone Audio Recordings: Observational Field Study, Filipe Barata, Peter Tinschert, Frank Rassouli, Claudia Steurer-Stey, Elgar Fleisch, Milo Puhan, Martin Brutsche, David Kotz, Tobias Kowatsch
Dartmouth Scholarship
Background: Asthma is one of the most prevalent chronic respiratory diseases. Despite increased investment in treatment, little progress has been made in the early recognition and treatment of asthma exacerbations over the last decade. Nocturnal cough monitoring may provide an opportunity to identify patients at risk for imminent exacerbations. Recently developed approaches enable smartphone-based cough monitoring. These approaches, however, have not undergone longitudinal overnight testing nor have they been specifically evaluated in the context of asthma. Also, the problem of distinguishing partner coughs from patient coughs when two or more people are sleeping in the same room using contact-free audio …
Promising Swellable Floating Bupropion Tablets: Formulation, In Vitro/In Vivo Evaluation And Comparative Pharmacokinetic Study In Human Volunteers, Mahmoud Teaima, Magdi M.A. Hamid, Nabil A. Shoman, Bhaskara R. Jasti, Mohamed A. El-Nabarawi
Promising Swellable Floating Bupropion Tablets: Formulation, In Vitro/In Vivo Evaluation And Comparative Pharmacokinetic Study In Human Volunteers, Mahmoud Teaima, Magdi M.A. Hamid, Nabil A. Shoman, Bhaskara R. Jasti, Mohamed A. El-Nabarawi
Pacific Faculty Work
Purpose: Bupropion is an antidepressant drug that facilitates weight loss. It is a highly water-soluble drug that needs multiple dosing, so it is considered a potential candidate for oral controlled-release dosage form. The aim of this research was to formulate and evaluate satiety-inducing swellable floating bupropion tablets by direct compression targeting depression associated with eating disorders. Various combinations of natural and semi-synthetic hydrogels were selected to achieve maximum swelling and remaining buoyant in the stomach. This synergistically enhances weight loss by increasing satiety. Methods: An I-optimal mixture design was conducted to establish the optimal quantitative composition of tablets. Friability, floating …
The Spectrum And Severity Of Bleeding In Adolescents With Low Von Willebrand Factor-Associated Heavy Menstrual Bleeding., Lakshmi Srivaths, Charles G. Minard, Sarah H. O'Brien, Allison P Wheeler, Eric Mullins, Mukta Sharma, Robert Sidonio, Shilpa Jain, Ayesha Zia, Margaret V. Ragni, Roshni Kulkarni, Jennifer E. Dietrich, Peter A. Kouides
The Spectrum And Severity Of Bleeding In Adolescents With Low Von Willebrand Factor-Associated Heavy Menstrual Bleeding., Lakshmi Srivaths, Charles G. Minard, Sarah H. O'Brien, Allison P Wheeler, Eric Mullins, Mukta Sharma, Robert Sidonio, Shilpa Jain, Ayesha Zia, Margaret V. Ragni, Roshni Kulkarni, Jennifer E. Dietrich, Peter A. Kouides
Manuscripts, Articles, Book Chapters and Other Papers
Low von Willebrand factor (VWF) in adults is associated with significant bleeding, most notably heavy menstrual bleeding (HMB) and postpartum hemorrhage, although this has not been characterized in adolescents. The objectives of this analysis of a multicenter single arm observational cohort study in adolescents with low VWF-associated HMB were to describe the bleeding phenotype, HMB severity, and related complications. Eligibility criteria included postmenarchal females(Pictorial Blood Assessment Chart [PBAC] score >100) and low VWF (2 values of VWF activity ≥30 and ≤50 IU/dL). Patients diagnosed with other bleeding disorders were ineligible. Clinical phenotype data, including PBAC and Bleeding Assessment Tool (BAT) …
Reduced Intensity Conditioning For Acute Myeloid Leukemia Using Melphalan- Vs Busulfan-Based Regimens: A Cibmtr Report, Zheng Zhou, Rajneesh Nath, Jan Cerny, Hai-Lin Wang, Mei-Jie Zhang, Hisham Abdel-Azim, Vaibhav Agrawal, Gulrayz Ahmed, A Samer Al-Homsi, Mahmoud Aljurf, Hassan B Alkhateeb, Amer Assal, Ulrike Bacher, Ashish Bajel, Qaiser Bashir, Minocher Battiwalla, Vijaya Raj Bhatt, Michael Byrne, Jean-Yves Cahn, Mitchell Cairo, Hannah Choe, Edward Copelan, Corey Cutler, Moussab B Damlaj, Zachariah Defilipp, Marcos De Lima, Miguel Angel Diaz, Nosha Farhadfar, James Foran, César O Freytes, Aaron T Gerds, Usama Gergis, Michael R Grunwald, Zartash Gul, Mehdi Hamadani, Shahrukh Hashmi, Mark Hertzberg, Gerhard C Hildebrandt, Nasheed Hossain, Yoshihiro Inamoto, Luis Isola, Tania Jain, Rammurti T Kamble, Muhammad Waqas Khan, Mohamed A Kharfan-Dabaja, Partow Kebriaei, Natasha Kekre, Nandita Khera, Hillard M Lazarus, Jane L Liesveld, Mark Litzow, Hongtao Liu, David I Marks, Rodrigo Martino, Vikram Mathews, Asmita Mishra, Hemant S Murthy, Arnon Nagler, Ryotaro Nakamura, Sunita Nathan, Taiga Nishihori, Rebecca Olin, Richard F Olsson, Neil Palmisiano, Sagar S Patel, Mrinal M Patnaik, Attaphol Pawarode, Miguel-Angel Perales, Ioannis Politikos, Uday Popat, David Rizzieri, Brenda M Sandmaier, Bipin N Savani, Sachiko Seo, Nirav N Shah, Geoffrey L Uy, David Valcárcel, Leo F Verdonck, Edmund K Waller, Youjin Wang, Daniel Weisdorf, Baldeep Wirk, Eric Wong, Jean A Yared, Wael Saber
Reduced Intensity Conditioning For Acute Myeloid Leukemia Using Melphalan- Vs Busulfan-Based Regimens: A Cibmtr Report, Zheng Zhou, Rajneesh Nath, Jan Cerny, Hai-Lin Wang, Mei-Jie Zhang, Hisham Abdel-Azim, Vaibhav Agrawal, Gulrayz Ahmed, A Samer Al-Homsi, Mahmoud Aljurf, Hassan B Alkhateeb, Amer Assal, Ulrike Bacher, Ashish Bajel, Qaiser Bashir, Minocher Battiwalla, Vijaya Raj Bhatt, Michael Byrne, Jean-Yves Cahn, Mitchell Cairo, Hannah Choe, Edward Copelan, Corey Cutler, Moussab B Damlaj, Zachariah Defilipp, Marcos De Lima, Miguel Angel Diaz, Nosha Farhadfar, James Foran, César O Freytes, Aaron T Gerds, Usama Gergis, Michael R Grunwald, Zartash Gul, Mehdi Hamadani, Shahrukh Hashmi, Mark Hertzberg, Gerhard C Hildebrandt, Nasheed Hossain, Yoshihiro Inamoto, Luis Isola, Tania Jain, Rammurti T Kamble, Muhammad Waqas Khan, Mohamed A Kharfan-Dabaja, Partow Kebriaei, Natasha Kekre, Nandita Khera, Hillard M Lazarus, Jane L Liesveld, Mark Litzow, Hongtao Liu, David I Marks, Rodrigo Martino, Vikram Mathews, Asmita Mishra, Hemant S Murthy, Arnon Nagler, Ryotaro Nakamura, Sunita Nathan, Taiga Nishihori, Rebecca Olin, Richard F Olsson, Neil Palmisiano, Sagar S Patel, Mrinal M Patnaik, Attaphol Pawarode, Miguel-Angel Perales, Ioannis Politikos, Uday Popat, David Rizzieri, Brenda M Sandmaier, Bipin N Savani, Sachiko Seo, Nirav N Shah, Geoffrey L Uy, David Valcárcel, Leo F Verdonck, Edmund K Waller, Youjin Wang, Daniel Weisdorf, Baldeep Wirk, Eric Wong, Jean A Yared, Wael Saber
Faculty, Staff and Students Publications
There is a lack of large comparative study on the outcomes of reduced intensity conditioning (RIC) in acute myeloid leukemia (AML) transplantation using fludarabine/busulfan (FB) and fludarabine/melphalan (FM) regimens. Adult AML patients from Center for International Blood and Marrow Transplant Research who received first RIC allo-transplant between 2001 and 2015 were studied. Patients were excluded if they received cord blood or identical twin transplant, total body irradiation in conditioning, or graft-versus-host disease (GVHD) prophylaxis with in vitro T-cell depletion. Primary outcome was overall survival (OS), secondary end points were leukemia-free survival (LFS), nonrelapse mortality (NRM), relapse, and GVHD. Multivariate survival …
Drug-Resistant Epilepsy In Children With Juvenile Huntington's Disease: A Challenging Case And Brief Review, Abdulhafeez Khair, Jessica Kabrt, Stephen Falchek
Drug-Resistant Epilepsy In Children With Juvenile Huntington's Disease: A Challenging Case And Brief Review, Abdulhafeez Khair, Jessica Kabrt, Stephen Falchek
Department of Neurology Faculty Papers
Huntington's Disease (HD) is an autosomal dominant neurodegenerative disorder with a progressive decline in cognitive, motor, and psychological function. Chorea tends to be the most common associated movement disorder, although other variants of several abnormal movements are also seen. Adult-onset HD is the most common subtype. Juvenile Huntington's disease (JHD) accounts for 5%-10% of all HD cases and presents as a rapidly progressive disorder with a multitude of characteristics. We report on a 9-year-old male with JHD who presented with refractory epilepsy. His EEG findings, seizure type, and antiepileptic drug usage are discussed with a brief review of the currently …
From R0 To The Herd: A Review Of The Rules Of Contagion, By Adam Kucharski, Nathan D. Grawe
From R0 To The Herd: A Review Of The Rules Of Contagion, By Adam Kucharski, Nathan D. Grawe
Numeracy
Adam Kucharski. 2020. The Rules of Contagion: Why Things Spread--and Why They Stop; (London: Profile Books, Ltd.). Hardback ISBN 978-17-88-16019-3. E-book ISBN 978-17-82-83430-4.
Kucharski's well-timed Rules of Contagion provides an introduction to the mathematical and epidemiological principles behind contagious phenomenon. While the author's primary expertise stems from work on biological epidemics, the book points to examples from a wide range of fields including finance, psychology, computer science, and criminology. As such, selections of the book could be used by faculty in a wide range of classes to show how our recent experience with a viral epidemic might add to …
Factors In The Probability Of Covid-19 Transmission In University Classrooms, Charles Connor
Factors In The Probability Of Covid-19 Transmission In University Classrooms, Charles Connor
Numeracy
University students and faculty members need an effective strategy to evaluate and reduce the probability that an individual will become infected with COVID-19 as a result of classroom interactions. Models are developed here that consider the probability an individual will become infected as a function of: prevalence of the disease in the university community, number of students in class, number of class meetings, and transmission rate in the classroom given the presence of an infected individual. Absolute probabilities that an individual will become infected in a classroom environment cannot be calculated because some of these factors have unknown values. Nevertheless, …
Perioperative Management Of Pheochromocytoma Resection In A Patient With A Continuous Flow Left Ventricular Assist Device, Arif Albulushi Md, Ronald Zolty Md Phd, Brian Lowes Md, Phd, Amy L. Duhacheck-Stapleman Md, Tal Sandler Md, James N. Sullivan Md, Douglas Stoller Md Phd
Perioperative Management Of Pheochromocytoma Resection In A Patient With A Continuous Flow Left Ventricular Assist Device, Arif Albulushi Md, Ronald Zolty Md Phd, Brian Lowes Md, Phd, Amy L. Duhacheck-Stapleman Md, Tal Sandler Md, James N. Sullivan Md, Douglas Stoller Md Phd
Journal of the Saudi Heart Association
Current generation LVADs provide continuous blood flow which has been shown to increase sympathetic tone. Pheochromocytoma is a rare neuroendocrine tumor which classically presents with episodic hypertension, palpitations and headaches. Careful perioperative management with alpha blockade is required to prevent cardiovascular complications, specifically hypertensive crisis. Here we present a description of perioperative management of pheochromocytoma in a patient with a continuous flow LVAD. Traditional assessment of sympathetic tone is challenging in LVAD patients due to the presence of continuous circulatory flow. Invasive management via an arterial line was useful in perioperative management, allowing for accurate circulatory monitoring and hemodynamic control. …
Hba-Deals: Accurate And Simultaneous Identification Of Differential Expression And Splicing Using Hierarchical Bayesian Analysis., Guy Karlebach, Peter Hansen, Diogo Ft Veiga, Robin Steinhaus, Daniel Danis, Sheng Li, Olga Anczuków, Peter N Robinson
Hba-Deals: Accurate And Simultaneous Identification Of Differential Expression And Splicing Using Hierarchical Bayesian Analysis., Guy Karlebach, Peter Hansen, Diogo Ft Veiga, Robin Steinhaus, Daniel Danis, Sheng Li, Olga Anczuków, Peter N Robinson
Faculty Research 2020
We present Hierarchical Bayesian Analysis of Differential Expression and ALternative Splicing (HBA-DEALS), which simultaneously characterizes differential expression and splicing in cohorts. HBA-DEALS attains state of the art or better performance for both expression and splicing and allows genes to be characterized as having differential gene expression, differential alternative splicing, both, or neither. HBA-DEALS analysis of GTEx data demonstrated sets of genes that show predominant DGE or DAST across multiple tissue types. These sets have pervasive differences with respect to gene structure, function, membership in protein complexes, and promoter architecture.
2020-07-13_Michigandaily_Covidmap, Michigan Department Of Health & Human Services
2020-07-13_Michigandaily_Covidmap, Michigan Department Of Health & Human Services
Daily Michigan COVID-19 Update
The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.
The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.
The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …
The Experience Of Being A Parent Of A Child Who Stutters And Subsequent Involvement In Support Groups: A Narrative Study, Katlyn A. Ferguson, Richard Arenas
The Experience Of Being A Parent Of A Child Who Stutters And Subsequent Involvement In Support Groups: A Narrative Study, Katlyn A. Ferguson, Richard Arenas
Speech and Hearing Sciences ETDs
INTRODUCTION: Developmental stuttering generally begins after a period of typical fluency and is highly variable in its presentation and persistence. This variability along with the lack of a definitive cause and social stigma often negatively impact both children who stutter (CWS) and their caregivers. However, research on the specific effects of stuttering on the caregiver is quite sparse compared to research into the caregiver experience in other disorders. Additionally, although social support has been identified as a primary protective factor for other caregivers, little evidence exists to show how support groups benefit caregivers of CWS.
METHOD: Five parents participated in …
2020-07-13_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services
2020-07-13_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services
Michigan COVID-19 Syndromic Surveillance System Data
The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.
Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …
2020-07-13_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services
2020-07-13_Michiganoverview_Covidlongtermcare, Michigan Department Of Health & Human Services
Michigan COVID-19 Long Term Care Data
The COVID Long Term Care Facilities page was obtained from Michigan's COVID-19 data page: https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173-526911--,00.html.
This report is created by the Michigan Department of Health & Human Services from data self-reported by long-term care facilities into EMResource. Data is updated on an ongoing basis.
The data below represents a cumulative total of confirmed COVID-19 resident cases, cumulative total of suspected and confirmed resident deaths, cumulative total of confirmed COVID-19 staff cases, and cumulative total of suspected and confirmed staff deaths reported by SNFs in Michigan since January 1, 2020. Case numbers are provisional and may change as facilities correct …
2020-07-13_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services
2020-07-13_Michiganoverview_Covidstats, Michigan Department Of Health & Human Services
Cumulative Michigan COVID-19 Data
The COVID Overview page was obtained from Michigan's main COVID-19 page: https:/www.michigan.gov/coronavirus/0,9753,7-406-98163-520743--,00.html.
This report is provisional and subject to change. City of Detroit and Wayne County are reported separately. MDHHS began tracking probable cases April 5, 2020. FCI indicates federal correctional institute. MDOC indicates Michigan Department of Corrections. Diagnostic tests, including nucleic acid amplification/real-time polymerase chain reaction (NAAT/RT-PCR) and rapid virus antigen detection point of care (POC) tests, look for current infection. Serology (antibody) tests are used to look for the possibility of previous infection.
Source: Michigan Disease Surveillance System (MDSS) and Vital Records
The website contained the tables …
Association Of Cardiovascular Risk Factor Profile And Financial Hardship From Medical Bills Among Non-Elderly Adults In The United States, Gowtham R. Grandhi, Javier Valero-Elizondo, Reed Mszar Reed Mszar, Eric J. Brandt, Amarnath Annapureddy, Rohan Khera, Anshul Saxena, Salim S. Virani, Ron Blankstein, Nihar R. Desai
Association Of Cardiovascular Risk Factor Profile And Financial Hardship From Medical Bills Among Non-Elderly Adults In The United States, Gowtham R. Grandhi, Javier Valero-Elizondo, Reed Mszar Reed Mszar, Eric J. Brandt, Amarnath Annapureddy, Rohan Khera, Anshul Saxena, Salim S. Virani, Ron Blankstein, Nihar R. Desai
Office of the Provost
Background: While optimal cardiovascular risk factor (CRF) profile is associated with lower mortality, morbidity, and healthcare expenditures among individuals with atherosclerotic cardiovascular disease (ASCVD), less is known regarding its impact on financial hardship from medical bills. Therefore, we assessed whether an optimal CRF profile is associated with a lower burden of financial hardship from medical bills and a reduction in cost-related barriers to health.
Methods: We used a nationally representative sample of adults between 18 and 64 years from the National Health Interview Survey between 2013 and 2017. We assessed ASCVD status and the number of risk factors to categorize …
Ada News - 07/13/2020, American Dental Association, Publishing Division
Ada News - 07/13/2020, American Dental Association, Publishing Division
ADA News
Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.