Medicine and Health Sciences Commons^™

Estimating The Heritability Of Experiencing Child Maltreatment In An Extended Family Design, Katharina Pittner, Marian J. Bakermans-Kranenburg, Lenneke R. A. Alink, Renate S. M. Buisman, Lisa J. M. Van Den Bergo, Laura H. C. G. C. Compier-De Block, Alexandra Voorthuis, Bernet M. Elzinga, Jolanda Lindenberg, Marieke S. Tollenaar, Marielle Linting, Vincent P. Diego, Marinus H. Van Ijzendoorn

School of Medicine Publications

Child-driven genetic factors can contribute to negative parenting and may increase the risk of being maltreated. Experiencing childhood maltreatment may be partly heritable, but results of twin studies are mixed. In the current study, we used a cross-sectional extended family design to estimate genetic and environmental effects on experiencing child maltreatment. The sample consisted of 395 individuals (225 women; M _age = 38.85 years, range_age = 7–88 years) from 63 families with two or three participating generations. Participants were oversampled for experienced maltreatment. Self-reported experienced child maltreatment was measured using a questionnaire assessing physical and emotional abuse, and physical …

Development Of Thrombocytopenia Is Associated With Improved Survival In Patients Treated With Immunotherapy, Hussein A. Assi

School of Medicine Publications

Background:

Immune-related adverse events are associated with efficacy of immune checkpoint inhibitors (ICIs). We hypothesize that immune-mediated thrombocytopenia could be a biomarker for response to ICIs.

Materials & methods:

This retrospective study included 215 patients with metastatic malignancies treated with ICIs. Patients were stratified by nadir platelet count. Outcomes of interest were progression-free survival and overall survival.

Results:

On multivariate analysis, grade 1 thrombocytopenia was positively associated with overall survival compared with patients who did not develop thrombocytopenia (hazard ratio [HR]= 0.28 [95% CI: 0.13–0.60]; p = 0.001), while grade 2–4 thrombocytopenia was not (HR= 0.36 [95% CI: 0.13–1.04]; p …

Cardiovascular End Points And Mortality Are Not Closer Associated With Central Than Peripheral Pulsatile Blood Pressure Components, Qi-Fang Huang, Lucas S. Aparicio, Lutgarde Thijs, Fang-Fei Wei, Jesus D. Melgarejo, Yi-Bang Cheng, Chang-Sheng Sheng, Wen-Yi Yang, Natasza Gilis-Malinowska, José Boggia

School of Medicine Publications

Pulsatile blood pressure (BP) confers cardiovascular risk. Whether associations of cardiovascular end points are tighter for central systolic BP (cSBP) than peripheral systolic BP (pSBP) or central pulse pressure (cPP) than peripheral pulse pressure (pPP) is uncertain. Among 5608 participants (54.1% women; mean age, 54.2 years) enrolled in nine studies, median follow-up was 4.1 years. cSBP and cPP, estimated tonometrically from the radial waveform, averaged 123.7 and 42.5 mm Hg, and pSBP and pPP 134.1 and 53.9 mm Hg. The primary composite cardiovascular end point occurred in 255 participants (4.5%). Across fourths of the cPP distribution, rates increased exponentially (4.1, …

Diagnostic Tests For Covid-19 Detection: A Hybrid Methodology. Pruebas De Diagnóstico Para Detectar La Covid-19: Una Metodología Híbrida., Alvaro Diaz-Badillo, María De Lourdes Muñoz, María Concepción Morales-Gómez, José D. Martínez-Ezquerro, Rosa María Quispe-Siccha, Juan Carlos Lopez Alvarenga

School of Medicine Publications

No abstract provided.

Modeling, Fabrication And Characterization Of Coated Calcium Phosphate Scaffolds Produced By 3d-Printing For Tissue Engineering Application, Touri Maria

Student Works (2020-2029)

A fully interconnected 3-dimensional scaffold with pre-determined dimensions and porosity can be attained by design-dependent rapid prototyping techniques which possess precise control over the internal and external architecture of the scaffolds thus they can overcome the problems associated with the process-dependent classical approaches. Interruption of vascular flow with fracture or surgical osteotomy results in a transient hypoxic gradient within the wound and subsequent tissue necrosis. Tissue engineering scaffolds with oxygen generating elements have shown to be able to increase the level of oxygen and cell survivability. In this study, biphasic calcium phosphate (BCP) scaffolds with the composition of 60% hydroxyapatite …

The Effect Of Random And Blocked Practice On Tennis Basic Skills Among University Students, Al. Azzawi Ali Ahmed Hameed

Student Works (2020-2029)

The purpose of this study was to investigate the effect of two different practices (Blocked & Random) on learning tennis basic skills (Forehand & Backhand) for Iraqi university students. A total of 90 students participated in this study. The study was conducted using quasi-experimental research design where tennis basic skills tests was administered to the students before and after the treatment process. The students were divided into three groups of 30 students each group. For the experimental groups, blocked practice was assigned to the first group while blocked practice was assigned to the second group. The controlled group followed traditional …

Use Of Video Modeling In Developing Social Skills Among Children With Autism Spectrum Disorder, En Ying Irene Tan

Student Works (2020-2029)

Children with Autism Spectrum Disorder (ASD) are poor in social interaction and following instruction. Most researchers of today focus on having the children to interact with toys to enhance their social skills, but not with other peers. This study was carried out to investigate the use of video modeling in developing social skills among children with ASD. The study uses single-subject design with multiple baseline graphs to examine the development of children’s social skills. This study consists of three sequential phases: 1) Baseline, 2) Intervention, and 3) Maintenance. Results show that children with ASD have social interaction with peers after …

Physical Activity, Eating Behaviours And Body Satisfaction Among Private Preschoolers In Putrajaya, Poh Then Woh

Student Works (2020-2029)

Numerous studies had focused on examining the physical activity level, eating behaviours and body satisfaction worldwide. Additionally, some researchers have explored the gender differences of primary school students and adolescents as well as the correlation between these three variables. However, there are fewer studies that involve preschoolers and young children. Hence, the purpose of this study is to seek better understanding of the physical activity level, eating behaviour and body satisfaction among pre-schoolers in Malaysia. The Federal Territory of Putrajaya was being selected as the study’s location as it marked the highest percentage of children; and highest overweight and obesity …

Child Body Fat And Body Mass Index: Which Determinants Are Most Important?, Marilyn Frenn, Astrida S. Kaugars, Juanita Terrie Garcia, Mauricio Garnier-Villarreal

College of Nursing Faculty Research and Publications

The purpose of this study was to examine child and parent determinants of children’s body fat percentage (BF%) along with their body mass index percentile (BMIp). Children’s BF% and BMIp auger lifelong health risks when elevated, and one in five children are affected. Participants (N = 135) included 62% female children; 50.7% Caucasian, 31.7% Hispanic, and 8.5% African American. Children were aged 9–15 years (2% underweight, 47.9% normal weight, 19.7% overweight, and 24.6% obese). Parent BMI average was 30.67 (1.4% underweight, 20.4% normal weight, 23.9% overweight, 40% obese, and 7% extreme obesity); 77.5% of the participating parents were mothers. …

Adoptive Treg Cell-Based Immunotherapy: Frontier Therapeutic Aspects In Rheumatoid Arthritis, Mahdi Zavvar, Sara Assadiasl, Sina Zargaran, Maryam Akhtari, Behzad Poopak, Rassoul Dinarvand, Yousef Fatahi, Lobat Tayebi, Narjes Soleimanifar, Mohammad Hossein Nicknam

School of Dentistry Faculty Research and Publications

The major current focus on treating rheumatoid arthritis is to put an end to long-term treatments and instead, specifically block widespread immunosuppression by developing antigen-specific tolerance, while also permitting an intact immune response toward other antigens to occur. There have been promising preclinical findings regarding adoptive Treg cells immunotherapy with a critically responsible function in the prevention of autoimmunity, tissue repair and regeneration, which make them an attractive candidate to develop effective therapeutic approaches to achieve this interesting concept in many human immune-mediated diseases, such as rheumatoid arthritis. Ex vivo or invivo manipulation protocols are not only utilized to correct …

Correlates Of Access To Hand Hygiene Resources In Ghanaian Households: An Exploratory Analysis Of The 2014 Demographic And Health Survey, Paul Lawer Kenney, Herman Nuake Kofi Agboh, Florence Akosua Agyemang, Seth Sylvester Dadzie, Henry Ofori Duah, Pascal Agbadi

College of Nursing Faculty Research and Publications

Objectives

Handwashing with soap and water remains the most effective public health measure to reduce the risk of infectious diseases, which kill over 2.5 million people annually, mostly children in developing countries. The absence of hand hygiene resources in homes put many at risk of these infectious diseases. In the wake of the outbreak of the COVID-19 pandemic, the World Health Organization (WHO) and governments around the world have stressed the importance of regular handwashing to prevent the spread of the virus. This suggests that research on water, sanitation, and hygiene issues deserve continuous scholarly attention. In Ghana, studies on …

Contemporary Nursing Graduates' Transition To Practice: A Critical Review Of Transition Models, Amanda C Graf, Elisabeth Jacob, Diane Twigg, Barbara Nattabi

Research outputs 2014 to 2021

AIM AND OBJECTIVE: To critically review contemporary transition theories to determine how they apply to the newly qualified graduate registered nurse programmes.

BACKGROUND: Graduate nurse transition to employment is the time of significant change which has resulted in high attrition rates. Graduates are often challenged by their expectation of nursing practice and the reality of the role. The transition from hospital-based training to university-based training has resulted in the need for primary employment to commence with graduate/orientation/internship programmes to help support new graduates transition into clinical practice. One transition model, Duchscher's stages of transition theory, utilised three former theories to …

Evaluation Of Red Blood Cell Count As An Ancillary Index To Hemoglobin Level In Defining The Severe Falciparum Malarial Anemia Among Ghanaian Children In Low-Resource Communities, Kwabena Nsiah, Bernard Bahaah, Bright Oppong Afranie, Emmanuel Acheampong

Research outputs 2014 to 2021

© 2020 The Author(s) Our study evaluated red blood cell count as supporting hematological index to hematocrit level in predicting severe malarial anemia instead of the hemoglobin levels among malaria-infected children in Ghana. This case-control study was conducted at the Komfo Anokye Teaching Hospital (KATH) in Kumasi, Ghana. The study recruited 139 children, of which 45 were Controls (C), 43 with severe malaria (SM), and 51 with mild malaria (MM). Validated questionnaires were administered to obtain the socio-demographic data from each respondent. Venous blood was obtained for parasitemia count and to determine the hematological profile of each participant. With point …

Long-Term Paleolithic Diet Is Associated With Lower Resistant Starch Intake, Different Gut Microbiota Composition And Increased Serum Tmao Concentrations, Angela Genoni, Claus T. Christophersen, Johnny Lo, Megan Coghlan, Mary C. Boyce, Anthony R. Bird, Philippa Lyons-Wall, Amanda Devine

Research outputs 2014 to 2021

© 2019, The Author(s). Background: The Paleolithic diet is promoted worldwide for improved gut health. However, there is little evidence available to support these claims, with existing literature examining anthropometric and cardiometabolic outcomes. Objective: To determine the association between dietary intake, markers of colonic health, microbiota, and serum trimethylamine-N-oxide (TMAO), a gut-derived metabolite associated with cardiovascular disease. Design: In a cross-sectional design, long-term (n = 44, > 1 year) self-reported followers of a Paleolithic diet (PD) and controls (n = 47) consuming a diet typical of national recommendations were recruited. Diets were assessed via 3-day weighed diet records; 48-h stool for …

Evaluation Of Gammah2ax In Buccal Cells As A Molecular Biomarker Of Dna Damage In Alzheimer’S Disease In The Aibl Study Of Ageing, Mohammad Sabbir Siddiqui, Maxime Francois, Stephanie Rainey-Smith, Ralph Martins, Colin L. Masters, David Ames, Christopher C. Rowe, Lance S. Macaulay, Michael F. Fenech, Wayne R. Leifert

Research outputs 2014 to 2021

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. In response to double-stranded breaks (DSBs) in chromosomal DNA, H2AX (a member of histone H2A family) becomes phosphorylated to form γH2AX. Although increased levels of γH2AX have been reported in the neuronal nuclei of Alzheimer’s disease (AD) patients, the understanding of γH2AX responses in buccal nuclei of individuals with mild cognitive impairment (MCI) and AD remain unexplored. In the current study, endogenous γH2AX was measured in buccal cell nuclei from MCI (n = 18) or AD (n = 16) patients and in healthy controls (n = 17) using laser scanning cytometry …

Cyclic Fatigue Resistance Of Three Heat-Treated Nickel-Titanium Instruments At Simulated Body Temperature, Shehabeldin Mohamed Saber Prof.Dr.

Dentistry

Introduction: The aim of this study was to evaluate the cyclic fatigue resistance of three heat-Treated nickel-Titanium (NiTi) systems at simulated body temperature. Materials and Methods: Twelve instruments of similar apical diameter (#25) from three engine-driven NiTi instruments; WaveOne Gold (WOG), Hyflex EDM (HEDM), and M Pro system were tested for cyclic fatigue resistance at 37°C in simulated root canals with 60° angle of curvature and 5 mm curvature radius. All instruments were operated until fracture occurred. Mean and standard deviation of the time to fracture and fragment length were calculated, and statistical significance was set at 5%. The morphological …

Combinatorial Pharmacogenomic Algorithm Is Predictive Of Citalopram And Escitalopram Metabolism In Patients With Major Depressive Disorder, Richard C. Shelton, Charles R. Conway, Et Al.

2020-Current year OA Pubs

Pharmacogenomic tests used to guide clinical treatment for major depressive disorder (MDD) must be thoroughly validated. One important assessment of validity is the ability to predict medication blood levels, which reflect altered metabolism. Historically, the metabolic impact of individual genes has been evaluated; however, we now know that multiple genes are often involved in medication metabolism. Here, we evaluated the ability of individual pharmacokinetic genes (CYP2C19, CYP2D6, CYP3A4) and a combinatorial pharmacogenomic test (GeneSight Psychotropic®; weighted assessment of all three genes) to predict citalopram/escitalopram blood levels in patients with MDD. Patients from the Genomics Used to Improve DEpression Decisions (GUIDED) …

Interventricular Septal Rupture In A 62-Year-Old Man With Familial Amyloid Polyneuropathy, Stefano Pidello, Erika Simonato, Fulvio Orzan, Simone Frea, Antonella Barreca, Mauro Rinaldi, Massimo Boffini

The Texas Heart Institute Journal

Cardiac involvement in familial amyloid polyneuropathy consists of arrhythmias, conduction disturbances, and heart failure. To our knowledge, heart rupture has never been described in association with this condition. We report the case of a 62-year-old man with a 6-year history of refractory familial amyloid polyneuropathy who underwent liver transplantation. The operation was complicated by severe hypotension because the neuropathy involved the autonomic system. Perioperatively, the patient had a myocardial infarction, and during the next 10 days, a complete interventricular septal rupture developed, resulting in a systemic-to-pulmonary shunt. Coronary angiographic findings were normal. However, the shunt caused unstable hemodynamics, resulting in …

Drug Delivery In Catheterized Arterial Blood Flow With Atherosclerosis, Saulo Orizaga, Daniel N. Riahi, Jose R. Soto

School of Mathematical & Statistical Sciences Faculty Publications

We study the problem of drug delivery in a catheterized artery in the presence of atherosclerosis. The problem is modeled in the context of a two-phase flow system which consists of red blood cells and blood plasma. The coupled differential equations for fluid (plasma) and particles (red cells) are solved for the relevant quantities in the reasonable limits. The drug delivery problem is modeled with a partial differential equation that is developed in terms of the drug concentration, blood plasma velocity, hematocrit value and the diffusion coefficient of the drug/fluid. A conservative-implicit finite difference scheme is develop in order to …

Vulvar Intravascular Papillary Endothelial Hyperplasia Or Masson's Tumor: A Case Report, Vania Nwokolo, Ravindra Veeramachaneni, Saul D. Rivas

School of Medicine Publications

Masson's tumor, also known as intravascular papillary endothelial hyperplasia (IPEH), is a rare and benign vascular disease in which there is a reactive hyperplasia of intravascular endothelial cells. This tumor is most commonly found in soft tissues in the head, neck and upper extremities. We report a rare case of IPEH on the vulva. A Hispanic woman in her mid-thirties presented with a painful and pruritic left vulvar mass. On physical examination, a pedunculated mass was visualized on the left labia majora. Under pathologic examination, it was concluded the lesion was IPEH and it was surgically excised. This is a …

Qtc Cutoff, Gender, Race And Age On Reporting Of Prolonged Qtc, Supraja Thunuguntla, Michael Machiorlatti

School of Medicine Publications

Background
The aim of the study is to evaluate the association of QTc cutoff, gender, race, and age on reporting of QTc interval prolongation.

Methods
Retrospective study of 147 patients admitted to our hospital or ER visit from January 2016 to May 2020. Simple descriptive statistics and longitudinal linear mixed model was performed on the 213 total observations from 147 patients.

Results
The average age of the patients was 65 (±17.8, 18-98) years. Females were 32% (n=47) and Hispanics 78.4% of sample. QTc prolongation was reported in 65% (n=138) of the 213 EKG’s. Calculated 90th and 99th percentile for QTC …

“Tomorrow Never Dies”: Recent Advances In Diagnosis, Treatment, And Prevention Modalities Against Coronavirus (Covid-19) Amid Controversies, Partha Laskar, Murali M. Yallapu, Subhash C. Chauhan

School of Medicine Publications

The outbreak of novel coronavirus disease (2019-nCoV or COVID-19) is responsible for severe health emergency throughout the world. The attack of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is found to be responsible for COVID-19. The World Health Organization has declared the ongoing global public health emergency as a pandemic. The whole world fights against this invincible enemy in various capacities to restore economy, lifestyle, and safe life. Enormous amount of scientific research work(s), administrative strategies, and economic measurements are in place to create a successful step against COVID-19. Furthermore, differences in opinion, facts, and implementation methods laid additional layers …

Association Of Tph1 And Serotonin Transporter Genotypes With Treatment Response For Suicidal Ideation: A Preliminary Study, David A Nielsen, Huiqiong Deng, Michelle A Patriquin, Mark J Harding, John Oldham, Ramiro Salas, J Christopher Fowler, B Christopher Frueh

Staff and Researcher Publications

Variants in three genes coding for components of the serotonergic system, the tryptophan hydroxylase 1 (TPH1) rs1799913, serotonin transporter (SLC6A4) 5-HTTLPR, and serotonin receptor 2A (HTR2A) rs6311, were evaluated for association with suicidal ideation (SI) and with recovery from SI in a psychiatric inpatient population. Five hundred and eighty-two adult inpatients, including 390 patients who had SI, collected from December 2012 to April 2016 were assessed. SI recovery, calculated as change in SI between the first two-week period after admission and weeks 5 and 6, was appraised for association with the three variants. In this preliminary study, both TPH1 and …

University Crime Alerts: Do They Contribute To Institutional Betrayal And Rape Myths?, Alexis A. Adams-Clark, Carly P. Smith, Prachi H. Bhuptani, Jennifer J. Freyd

Dignity: A Journal of Analysis of Exploitation and Violence

Universities are mandated by the Clery Act (20 USC § 1092(f)) to publicize the occurrence of certain campus crimes. Many universities rely on “Crime Alert” emails to quickly and effectively communicate when a crime has occurred. However, communications of sexual crimes are often narrow (e.g., limited to stranger-perpetrated crimes) and misleading (e.g., containing safety tips that are not applicable to most types of sexual violence). The current paper presents the results of two studies that test the effects of reading crime alert emails on subsequent endorsement of rape myths and institutional betrayal. In Study 1, participants read a typical crime …

Sexual Violence, Traumatic Memory, And Speculative Fiction As Action, Kate Rose

Dignity: A Journal of Analysis of Exploitation and Violence

Starhawk’s speculative novel City of Refuge (2015) depicts rape trauma and its consequences in a dystopian society that is the logical conclusion of patriarchy. French psychiatrist Muriel Salmona’s research on how traumatic memory contributes to inequality and how reconstructing narrative can heal survivors places her similarly at the intersection of story and activism. City of Refuge is a literary experiment focused on survivors of institutionalized sexual assault, while Salmona’s work maps consequences of traumatic memory linked to childhood sexual violence. The basic tenet of narrative medicine that life experience affects mental and physical health coincides with Salmona’s critique of how …

July / August 2020, Randy Curry, Cindy Brooks

RURAL ROCKS

Rural Rocks, the Rural Health Network newsletter by the SWOSU College of Pharmacy.

Covid-19: Health As A Common Good, Alfredo Morabia

Publications and Research

No abstract provided.

De Novo Variants Of Nr4a2 Are Associated With Neurodevelopmental Disorder And Epilepsy, Sakshi Singh, Rachel Slaugh, Jorge Granadillo, Et Al.

2020-Current year OA Pubs

PURPOSE: This study characterizes the clinical and genetic features of nine unrelated patients with de novo variants in the NR4A2 gene.

METHODS: Variants were identified and de novo origins were confirmed through trio exome sequencing in all but one patient. Targeted RNA sequencing was performed for one variant to confirm its splicing effect. Independent discoveries were shared through GeneMatcher.

RESULTS: Missense and loss-of-function variants in NR4A2 were identified in patients from eight unrelated families. One patient carried a larger deletion including adjacent genes. The cases presented with developmental delay, hypotonia (six cases), and epilepsy (six cases). De novo status was …

The Efficacy Of Lenvatinib Plus Everolimus In Patients With Metastatic Renal Cell Carcinoma Exhibiting Primary Resistance To Front-Line Targeted Therapy Or Immunotherapy, Lana Hamieh, Rachel L Beck, Valerie H Le, James J Hsieh

2020-Current year OA Pubs

BACKGROUND: Patients with primary refractory metastatic renal cell carcinoma (mRCC) have a dismal prognosis and poor response to subsequent treatments. While there are several approved second-line therapies, it remains critical to choose the most effective treatment regimen.

PATIENTS AND METHODS: We identified 7 patients with clear cell mRCC who had primary resistance to vascular endothelial growth factor (VEGF)-targeted tyrosine kinase inhibitors (TKIs) or immune checkpoint inhibitor (ICI) combination therapy. The patients were treated with lenvatinib (a multitargeted TKI) plus everolimus (a mammalian target of rapamycin inhibitor). Among these 7 patients, 2 had prior TKI therapy, 3 had prior ICI therapy, …

Boarding Of Critically Ill Patients In The Emergency Department, Nicholas M Mohr, Brian T Wessman, Benjamin Bassin, Marie-Carmelle Elie-Turenne, Timothy Ellender, Lillian L Emlet, Zachary Ginsberg, Kyle Gunnerson, Kevin M Jones, Bridgette Kram, Evie Marcolini, Susanna Rudy

2020-Current year OA Pubs

OBJECTIVES: Emergency department boarding is the practice of caring for admitted patients in the emergency department after hospital admission, and boarding has been a growing problem in the United States. Boarding of the critically ill has achieved specific attention because of its association with poor clinical outcomes. Accordingly, the Society of Critical Care Medicine and the American College of Emergency Physicians convened a Task Force to understand the implications of emergency department boarding of the critically ill. The objective of this article is to review the U.S. literature on (1) the frequency of emergency department boarding among the critically ill, …