Medicine and Health Sciences Commons^™

Wilson’S Disease Psychosis In A Young Man With Autism Spectrum Disorder: A Case Report And Focus On Management, Landon C. Sowell, Barbara L. Gracious

HCA Healthcare Journal of Medicine

Introduction

Wilson's disease is a rare autosomal recessive disorder, affecting approximately 1 in 30 000 individuals and is characterized by abnormal copper accumulation in the body, primarily affecting the liver and brain. Psychiatric manifestations as a first presentation, particularly psychosis, are less commonly recognized resulting in failure to begin treatment early in the course of the disease. This case report highlights a patient that presented to the hospital with psychosis, who was later diagnosed with Wilson’s disease. This case underscores the importance of considering organic causes in first-episode psychosis.

Case Presentation

An 18-year-old man with a history of autism spectrum …

Masld-Induced Hyperammonemia With Atypical, Restricted Diffusion Pattern Suggesting Mixed Metabolic And Hypoxic-Anoxic Injury, Renu Thomas, Nhuchau Tiffany Nguyen, Daniel Bao, Jonathan Tang, Uzma Ali, Damon Cao

HCA Healthcare Journal of Medicine

Background

Hepatic encephalopathy is a common cause of altered mental status for patients with decompensated cirrhosis. Their conditions typically improve with high-dose laxatives; if not optimally treated, can develop neurologic sequelae like cerebral edema and herniation. In severe cases, despite normal systemic oxygenation, hyperammonemia may result in mixed restricted diffusion patterns that partially resemble those seen in hypoxic-anoxic brain injury.

Case Presentation

A 61-year-old woman with cirrhosis secondary to metabolic dysfunction-associated steatotic liver disease, scleroderma, and rheumatoid arthritis presented to the emergency room with altered mental status. She was admitted to the intensive care unit (ICU) and was intubated due …

Presentation Of Cutaneous Large B-Cell Lymphoma, Leg Type, Francisca I. Valenzuela, Michael R. Hohnadel

HCA Healthcare Journal of Medicine

A man over the age of 89 presented with 2 violaceous, ulcerated plaques on his left lower leg, which developed over a 4-month period following a fall. The patient reported the initial formation of a solitary lump, which gradually enlarged and began bleeding a few weeks before his clinic visit. A histological examination of 2 biopsy samples revealed a dermal proliferation of large, severely atypical lymphoid cells with mitotic figures. Immunohistochemistry showed positivity for CD20, Bcl2, Bcl6, and MUM1, with cytokeratin 20 (CK20) negativity and a high percentage (80%-90%) of C-MYC positivity, which was consistent with a primary cutaneous diffuse …

Optimal Local Impedance Parameters For Catheter Ablation Of The Cavo-Tricuspid Isthmus In Atrial Flutter Patients: A Retrospective Analysis, Yamann Sahlool, Yann Dacquay, Saro Avedikian, Jeong Hwan J. Kim, Ali Sovari

HCA Healthcare Journal of Medicine

Background

Atrial flutter is a common arrhythmia, and catheter ablation offers a potentially curative intervention. However, there is a continued desire to enhance the procedure’s efficiency and safety to optimize patient outcomes. Recently, local impedance (LI) has garnered attention as a novel approach to optimizing ablation procedures. The parameters of LI change when associated with durable ablation lesions for cavo-tricuspid isthmus (CTI) which remains poorly defined. This study aims to address this gap through analysis of gathered data.

Methods

We conducted a retrospective data analysis of 121 consecutive patients who underwent local impedance-guided catheter ablation of the CTI for typical …

Postoperative Urinary Retention After Hernia Repair: A Randomized Controlled Trial Identifying Patients At Risk And Assessing The Incidence After Tamsulosin Pretreatment, Brandon M. Epps, Evelyn Coile, Margaret Carey, Oliver Whipple, Robert Kelly, Christopher Senkowski, James Garber

HCA Healthcare Journal of Medicine

Introduction

Postoperative urinary retention following hernia repair is a common complication, with its incidence ranging from 2%-30%. Treatment typically consists of a 5-alpha-reductase inhibitor, like tamsulosin. The goal of this study was to identify whether pretreatment with tamsulosin 7 days prior to an elective hernia repair reduced the rate of postoperative urinary retention.

Methods

A single institution randomized controlled trial was conducted with 140 patients. Patients were randomly assigned to either a control or treatment group, with all patients completing a pre- and postoperative International Prostate Symptom Score (IPSS). The inclusion criteria were men with no history of tamsulosin usage …

The Top Twenty-Five Most Influential Articles In Surgery For Colorectal Cancer, Dana Poloni, Andrew Anklowitz, Fred Kobylarz, Christina Monaco Poloni, Ankit Dhiman, Pamela Burgess, Andrew Schlussel

HCA Healthcare Journal of Medicine

Background

This article provides surgical trainees with a ranked list of the foundational literature that guides the contemporary surgical management of colorectal cancer and shows the evolution of surgical techniques in the field.

Methods

We assessed the surgical literature using the Web of Science and other ranking systems to create a ranked list of published articles on colorectal cancer surgery.

Results

We compiled a ranked list of the top 25 articles in the surgical management of colorectal cancer, based on the citation density score (mean number of citations per year) and the individual author H-index. The mean density score of …

Role-Playing For Rehabilitation: Enhancing Empathy Among Juveniles In Correctional Facilities, Nina Permatasari, Muhammad Arsyad, Muhammad Andri Setiawan, Hendro Yulius Suryo Putro, Muhammad Fajar Riva’I, Wiwik Widyanti

Buletin Konseling Inovatif

This study examines the effectiveness of role-playing-based counseling services in enhancing empathy among children at Juvenile Rehabilitation Center Class I Martapura. Employing a quantitative approach, the research utilized a one-group pre-test post-test experimental design to measure changes in empathy levels before and after the intervention. A total of 32 children participated in the study. Data were collected using two instruments: the Empathy Scale and the Role-Playing Engagement Questionnaire. The intervention consisted of structured role-playing sessions designed to improve both cognitive and affective components of empathy. Data analysis using paired sample t-tests revealed a statistically significant increase in empathy scores, with …

Bibliometric Analysis: Publish Or Perish And Vosviewer For Research Trends On Online Violence (2023–2025), Indriyana Rachmawati, Widya Juwita Sari, Sesya Dias Mumpuni

Buletin Konseling Inovatif

Cases of online violence have become increasingly widespread since the end of the COVID-19 pandemic, during which individuals began to grow dependent on the digital world. The digital realm has become a fundamental aspect of human life, bringing with it new forms of online violence. Online violence such as threats, hate speech, harassment, and bullying has emerged as a new weapon to control, isolate, and even torment affected victims. However, only a small body of literature has explored the changing nature of online violence following COVID-19. This study aims to review the literature on patterns of online violence post-pandemic, focusing …

Harmonizing Hope: An Idea Of Music Therapy Interventions For Schizophrenia, Dominikus David Biondi Situmorang

Buletin Konseling Inovatif

Schizophrenia is typified by a wide range of symptoms, such as delusions, hallucinations, cognitive decline, and social disengagement. Even with improvements in pharmaceutical and psychosocial therapy, many people with schizophrenia still require supplementary treatment methods due to their chronic symptoms and functional limitations. Utilizing music's therapeutic capacity to address a variety of symptoms and enhance general well-being, music therapy has emerged as a possible supplementary intervention for schizophrenia. In this study, the author used a literature review with a Critically Appraised Topic (CAT); this research is a summary of the best available evidence regarding the focused aims. This CAT looks …

Integrating Islamic-Based Behavioral Activation With Buya Hamka's Tazkiyatun Nafs To Reduce Social Media-Induced Anxiety Among University Students, Dosi Juliawati, Hengki Yandri, Farid Imam Kholidin, Rasmita Rasmita, Daflaini Daflaini, Yatti Fidya

Buletin Konseling Inovatif

The pervasive use of social media has led to a growing concern regarding social media-induced anxiety among university students. This study aims to integrate Islamic-based Behavioral Activation with the concept of Tazkiyatun Nafs, defined as the purification of the soul or self-purification, as proposed by Buya Hamka, to reduce this anxiety among university students. The method employed is a Single-Subject Experimental Design involving three participants from IAIN Kerinci, all of whom exhibited the highest scores of social media anxiety. Data were collected using the Social Media Anxiety Scale (SMAS) and analyzed through visual data analysis. The results indicate that all …

Peaceful School Counselors For School Violence In The Digital Era, Ahmad Yusuf Sobri, Nur Mega Aris Saputra, Dzulkifli Abdullah

Buletin Konseling Inovatif

The problem of violence that occurs in the world of education is a manifestation of the incomplete realization of schools as safe places. One strategy to make this happen is through the implementation of peace education in schools that involves all school members. School counselors are one of the key roles needed for the implementation of peace education in schools. This study aims to find out the role of school counselors in implementing peace education in schools. The study is a systematic literature review using the PRISMA stages. Fifteen academic articles were selected based on the main keywords: peace education …

The Role Of Self-Management Techniques For Reducing Gadget Addiction: Empowering Students Toward Healthier Digital Habit, Dian Ari Widyastuti, Lucky Resta Widias Putri

Buletin Konseling Inovatif

This study aims to examine the effectiveness of individual counseling using self-management techniques in reducing gadget addiction among students. The research employed an experimental approach with a single-subject design (SSD). One participant, a student from Yogyakarta, Indonesia was selected through purposive sampling. Data were collected using observation guidelines and a gadget addiction scale. Data analysis in single-subject research emphasizes individual data, and therefore, this study utilized visual analysis through graphical representations. The results of the visual analysis indicated a reduction in gadget addiction, as demonstrated by the A-B-A design graph. Based on these findings, it can be concluded that individual …

Peace Counseling In The Scientific Spotlight: A Bibliometric Analysis Of Global Research Trends, Wahyu Nanda Eka Saputra

Buletin Konseling Inovatif

This study aims to map global trends in peace counseling research using a bibliometric approach. Data were taken only from the Scopus database, focusing on publications containing keywords related to peace counseling, such as peace counseling, peace psychotherapy, and peacebuilding therapy. The analysis was conducted on 769 selected documents published between 1937 and 2025. The results showed a significant increase in publications since 2020, reflecting the growing need for counseling approaches that support peace and psychological well-being. Authors from various countries made different contributions, with the United States dominating the number of publications and citations, while developing countries such as …

Validation Of Micro Digital Content Model Of Project-Based Learning For Guidance And Counseling Courses In Non-Formal Education, Ella Faridati Zen, Yuliati Hotifah, Riskiyana Prihatiningsih, Nur Mega Aris Saputra

Buletin Konseling Inovatif

The research aims to produce a product in the form of a learning device for guidance and counseling courses in non-formal education in the form of micro digital based on project-based learning, which is theoretically accepted through expert testing. The development method uses the ADDIE design, with the procedures of Analysis, Design, Development, Implementation and Evaluation. The trial subjects or product assessors consist of material experts and media experts in the field of guidance and counseling. Data were collected with expert assessment instruments and analyzed using the average technique. The expert assessment of the product by material experts produced an …

Evaluation Of The Efficacy Of Injection Of Platelet-Rich Plasma For The Management Of “Peyronie’S Disease” And Erectile Dysfunction, Marwan Abdulaziz Ibrahim

Al-Qadisiyah Medical Journal

Abstract: This study evaluates and determines the therapeutic effects of platelet-rich plasma injection for the management of Peyronie’s disease and erectile dysfunction. Patients & Methods: From March 2021 until March 2022, a prospective study was conducted on 50 patients with Peyronie’s disease, erectile dysfunction, and penile curvature less than 60 degrees (mild to moderate penile curvature). All participants were subjected to 8 repeated injections of PRP weekly in the dominant penile plaque, with follow-up over 6 months of collected data that included orientation of curvature, injection technique, and the results in both quantitative (i.e., curvature estimations) and qualitative (erectile state …

Comparative Analysis Of Papillary Thyroid Carcinoma And Benign Lesions; Immunohistochemical Diagnostic Markers And Their Gene Expression Correlation, Esraah Alharris, Samah Alkhalidy, Dina Saleh

Al-Qadisiyah Medical Journal

Background: Papillary thyroid carcinoma (PTC) incidence has increased globally, but it is unclear if this was because of an improvement in the patient’s knowledge or if the tumor was incidentally discovered. The microscopical features of the nuclei are the gold standard for diagnosing PTC. Many immunohistochemical markers have been used to accurately diagnose PTC, such as CK-19, TTF-1, HBME-1, ret, and S-100. Objectives: To assess the incidence of PTC in the Al-Qadisiyah governorate and examine the expression of several markers by immunohistochemistry in thyroid tissue biopsies. Materials and Methods: Two hundred and twenty surgically resected Thyroid glands were implanted in …

Faktor-Faktor Yang Berhubungan Dengan Kualitas Hidup Pasien Geriatri Yang Menjalani Hemodialisis, Nurhidayat Mohammad, Czeresna Heriawan Soejono, Aida Lydia, Ikhwan Rinaldi, Muhammad Syafiq, Elizabeth Yasmine Wardoyo

Jurnal Penyakit Dalam Indonesia

Introduction. The decline in quality of life among geriatric patients undergoing hemodialysis has a negative impact on treatment adherence, physical functioning, dietary patterns, and mortality. This study was conducted to assess the quality of life of geriatric hemodialysis patients and its association with comorbidities, functional status, frailty, sarcopenia, nutritional status, depression, hemoglobin levels, hemodialysis vintage, vascular access, and hemodialysis adequacy.

Methods. This study employed a cross-sectional design with primary data collection. Consecutive sampling was used to recruit participants. The study was conducted at the hemodialysis units of Cipto Mangunkusumo National General Hospital (RSCM), Persahabatan National General Hospital (RSP), …

Rekam Medis Elektronik Berbasis Artificial Intelligence: Sudahkan Saatnya Digunakan?, Sukamto Koesnoe

Jurnal Penyakit Dalam Indonesia

No abstract provided.

Korelasi Kadar Serum Vegf-A Dengan Rasio Albumin-Kreatinin Urin Pada Pasien Penyakit Ginjal Diabetik, Hannie Q. Syaiful, Drajad Priyono, Harnavi Harun, Arina W. Murni, Akmal M. Hanif, Eifel Faheri, Arnelis Arnelis, Vesri Yoga

Jurnal Penyakit Dalam Indonesia

Introduction. Diabetic kidney disease (DKD) is a major microvascular complication of diabetes mellitus, characterized by persistent albuminuria and a progressive decline in glomerular filtration rate (GFR), making it a leading cause of chronic kidney disease (CKD) and end-stage renal disease. Vascular endothelial growth factor-A (VEGF-A) is implicated in the pathogenesis of DKD, being overexpressed in the kidneys and contributing to increased vascular permeability, inflammation, and fibrosis. Albuminuria, an early indicator of renal damage in DKD, is a strong predictor of CKD progression and cardiovascular events. The urine albumin-to-creatinine ratio (UACR) is the recommended test for detecting and monitoring albuminuria. …

Kadar Transthyretin Plasma Pada Lanjut Usia Sarkopenia Dan Non-Sarkopenia, R. Ifan A. Fahrurozi, Rose D. Martini, Roza Mulyana, Arina W. Murni, Eva Decroli, Saptino Miro, Deka Viotra, Vesri Yoga

Jurnal Penyakit Dalam Indonesia

Introduction. Sarcopenia is a geriatric syndrome marked by an age-related decline in muscle mass, which is affected by protein intake. Transthyretin is a visceral protein used to evaluate nutritional status and acts as a positive regulator of muscle mass. This study aimed to assess the difference in plasma transthyretin levels between elderly groups with and without sarcopenia.

Methods. This was an analytical observational study with a cross-sectional approach. Subjects were elderly patients who visited the Internal Medicine Polyclinic of Dr. M. Djamil Hospital Padang and met the inclusion and exclusion criteria from August to September 2024. Subjects were …

Optimalisasi Rekam Medis Elektronik Berbasis Artificial Intelligence, Ikhwan Rinaldi, Wahyu Sulistiadi

Jurnal Penyakit Dalam Indonesia

Electronic medical records (EMRs) are essential to modern healthcare systems, yet their implementation continues to face challenges such as disruption of doctor–patient communication, administrative burden, and documentation structures misaligned with clinicians’ clinical reasoning processes. This narrative review aims to assess the limitations of conventional EMRs and examine the potential of artificial intelligence (AI) to improve documentation efficiency, accuracy, and overall clinical performance. The literature indicates that AI technologies, including machine learning, deep learning, and natural language processing, can automate documentation, streamline workflows, enhance decision support, and reduce physician burnout, thereby allowing clinicians to devote more attention to patient care. Nevertheless, …

Faktor Prediktif Post Dialysis Fatigue Sedang Pada Pasien Yang Menjalani Hemodialisis Reguler, Ivan Virnanda Amu, Maruhum Bonar H Marbun, Pringgodigdo Nugroho, Ikhwan Rinaldi, Hamzah Shatri, Nunuk Mardiana, Rudy Hidayat, Endang Susalit, Evy Yunihastuti, Dyah Purnamasari, Elizabeth Y. Wardoyo

Jurnal Penyakit Dalam Indonesia

Introduction. Fatigue is often found in patients with CKD-HD. Fatigue serves as an indicator of mortality and may be a viable target in a treatment strategy. Current research has not established the determinants of moderate PDF in individuals with CKD who are undergoing HD. Therefore, this study was conducted to prove the predictor factors of moderate PDF.

Methods. A retrospective cohort study in CKD-HD patients at Fatmawati Central General Hospital during the period of November-December 2024. The independent variables of this study are comorbidities, MIS, depression, intradialytic SBPV, dialysis vintage, UFG, IDWG, and anemia status. Primary data from …

Pengaruh Ivabradin Terhadap Variabilitas Detak Jantung Pada Gagal Jantung Dengan Fraksi Ejeksi Rendah Akibat Penyakit Jantung Koroner, Handy Kurnia, Charles Limantoro, Friska Anggraini Helena Silitonga, Andreas Arie Setiawan

Jurnal Penyakit Dalam Indonesia

Introduction. Heart failure is one of the major challenges in global health due to its significant contribution to morbidity and mortality. One of the pathophysiological aspects is autonomic nervous system dysfunction which can be monitored through heart rate variability (HRV) parameters. Ivabradine is a pharmacological agent that potentially improves the balance of sympathetic and parasympathetic tone. This study was designed to evaluate the impact of ivabradine administration on HRV parameters in heart failure with reduced ejection fraction (≤40%) due to coronary heart disease in Indonesian population.

Methods. This study used a quasi-experimental research type with a pretest and posttest …

Polisitemia Sekunder Pada Pasien Laki-Laki Muda Dengan Sindrom Nefrotik, Ariani Intan Wardhani, Pringgodigdo Nugroho, Ikhwan Rinaldi, Meilania Sarasawati, Monik Ediana Miranda, Agnes Stephanie Harahap

Jurnal Penyakit Dalam Indonesia

Polycythemia is a condition characterized by an abnormal increase in the total red blood cell mass and is classified into primary and secondary polycythemia. Secondary polycythemia occurs as a physiological response to tissue hypoxia or increased erythropoietin production, without intrinsic abnormalities in erythroid progenitor cells. This condition is rare, particularly when associated with nephrotic syndrome. This report aims to describe a case of secondary polycythemia associated with focal segmental glomerulosclerosis (FSGS). A 20-year-old man presented with generalized edema for five months prior to admission, accompanied by foamy urine. Physical examination revealed peripheral edema and minimal ascites. Laboratory investigations demonstrated massive …

Going Nuclear: Exploring Mtor’S Transcriptional Role In Regulating Estrogen Receptor Positive Breast Cancer, Alek S. Torres

NYMC Student Theses and Dissertations

Global changes in gene expression are orchestrated by an array of transcription factors regulated by both extracellular and intracellular signals. The mechanistic target of rapamycin (mTOR) is a protein kinase that ubiquitously mediates signaling networks across every cell type, in two active complexes, mTORC1 and mTORC2. By phosphorylating its downstream targets, these classically cytosolic complexes regulate protein homeostasis, metabolism, cell growth, proliferation and survival. However, evidence from prostate cancer studies reveals mTOR and its partners can occupy the nucleus, where its interaction with chromatin (in complex with transcription factors) has been shown to regulate gene expression at the level of …

Perbandingan Ablasi Radiofrekuensi Dengan Transplantasi Hati Sebagai Terapi Kuratif Pada Karsinoma Hepatoseluler Stadium Awal: Laporan Kasus Berbasis Bukti, Mikhael Fabian Gunawan, Ranindita Amaida Safira, Gurmeet Singh, Kemal Fariz Kalista

Jurnal Penyakit Dalam Indonesia

Hepatocellular carcinoma (HCC) is the most common type of liver cancer and the second leading cause of cancer-related mortality worldwide. Liver transplantation is considered the definitive treatment for HCC; however, in Indonesia, adult liver transplantation is still rarely performed due to donor limitations and high costs. Radiofrequency ablation (RFA) has therefore become a preferred therapeutic option in the management of HCC. This report discuss about the survival and recurrence rates of HCC in patients treated with RFA compared with those undergoing liver transplantation. A literature search was conducted using the PubMed, Cochrane, Embase, and Scopus databases. Selected articles were screened …

Family Dementia Caregivers’ Disaster Preparedness In Chinese American Communities In New York City, Weiyu Mao, Bei Wu, Yaolin Pei, Zhen Cong

Health Sciences and Kinesiology Faculty Articles

Disaster preparedness is a significant public health concern. Disasters manifest in different forms and often lead to disruption of daily life. This is especially challenging for family dementia caregivers and their care recipients in the community. There remains much unknown regarding dementia caregiver disaster preparedness, especially in ethnic and racial communities. Guided by Protection Motivation Theory, with the backdrop of Hurricane Ida, this study explored the association between caregiving-related characteristics, cognitive appraisals, and disaster preparedness among caregivers in Chinese American communities. Data came from a pilot study on Chinese American family dementia caregivers in New York City between November 2021 …

Translating Evidence Into Action: Understanding How Community- Based Practitioners Make Intervention Implementation Decisions In Practice, Kristin C. Bennett

Dissertations and Theses (Open Access)

This study examined how community-based practitioners implement public health interventions in practice settings to identify gaps between existing implementation frameworks and real-world practice. Six farmers' markets in Southeast Texas served as cases to understand implementation decision-making by community-based practitioners addressing food access challenges. A qualitative case study approach was employed, using semi-structured interviews with program adopters and key stakeholders to examine how practitioners addressed food access problems, selected interventions, and navigated implementation decisions. This methodology captured the contextual nature of implementation decision-making in community settings. The findings revealed that program adopters recognized health problems through lived experience rather than formal …

Sirtuin 1 And Vitamin D3 As Prognostic Factors For Chronic Kidney Diseases And Nephrotic Syndrome, Fatima Al-Zahra’A ’Mohammed Radhi, Anwar Jasib Almzaiel

Al-Qadisiyah Medical Journal

Background: Kidney disease encompasses any form of damage or illness that affects these organs. Sirtuin-1 is an NAD+-dependent and class III histone deacetylase protein. Vitamin D3 is a fat-soluble steroid hormone. Recently, it was suggested that Sirtuin-1 and Vitamin D3 were involved in the pathogenesis of renal diseases. The exact protective mechanisms of Sirtuin-1 in renal diseases are still not completely understood. Objectives: The aim of this study was to explore the potential involvement of Sirtuin-1 in modulating the inflammatory response in various kidney diseases. Materials and Methods: The research study was carried out between October 2022 and April 2023. …

Molecular Detection Of Blaimp And Ompa Genes In Acinetobacter Baumannii Isolated From Burn Wound Infections, Zeinah Jawad Kadham, Manal Mohammed Kadham

Al-Qadisiyah Medical Journal

Background: antibiotic resistance in Acinetobacter baumannii can be acquired rapidly due mainly to chromosomal mutation, and its antibiotic-resistant metallo-beta-lactamase (MBL) production has been claimed to have a great contribution to nosocomial infection. Objective: This study aimed to detect the presence of the blaIMP carbapenemase-producing gene and the ompA gene in bacterial isolates obtained from burn patients, using the polymerase chain reaction (PCR) technique. Additionally, the study aimed to evaluate the role of these genes in antibiotic resistance. Methods: Cross-sectional research was conducted among a total of 150 clinical samples for patients of various ages and both sexes at the Specialist …