Medicine and Health Sciences Commons^™

Brief Report: Long-Acting Injectable Prep Can Substantially Reduce Hiv Incidence In Los Angeles County: A Simulation Study, Anna Hotton, Siri Chirumamilla, Ekow Kwa Sey, Nina T Harawa

Faculty, Staff and Student Publications

Background: Although oral pre-exposure prophylaxis (PrEP) has been instrumental in decreasing HIV incidence, its daily dosing regimen poses adherence challenges. Using an agent-based network model informed by empirical data, we simulate the impact of introducing long-acting injectable (LAI) PrEP among young Black men who have sex with men (YBMSM) in Los Angeles County, a group disproportionately affected by HIV.

Setting: Computer simulations using an agent-based network model.

Methods: We modeled HIV transmission among YBMSM over 10 years under scenarios varying the proportion of PrEP users opting for LAI instead of oral medications and adherence levels to LAI retention. The model …

Associations Of Moderate-To-Vigorous Physical Activity Timing With Type 2 Diabetes Incidence In Uk Biobank And Prevalent Glycemic Measures In Nhanes, Heming Wang, Martin K Rutter, Charles E Matthews, Joshua R Freeman, Ko Willems Van Dijk, Diana Van Heemst, Raymond Noordam

Faculty, Staff and Student Publications

Objective: We assessed the association between timing of moderate-to-vigorous physical activity (MVPA) with incident type 2 diabetes (T2D) and glycemic measures.

Research design and methods: Regression models were used to assess associations between accelerometer-derived MVPA timing and incident T2D in UK Biobank (UKB) (n = 84,528, prospective), prevalent diabetes, and glycemic measures in the National Health and Nutrition Examination Survey (NHANES) (n = 6,998, cross-sectional).

Results: In UKB, with early morning (0500-0959) MVPA as reference and before adjustment for total MVPA, "variable-timing" MVPA was associated with the lowest incident T2D risk; while after adjustment, afternoon-evening MVPA (1500-2400) showed the lowest …

E3 Ubiquitin Ligases And Asthma Relief, Ajay P. Nayak

Department of Medicine Faculty Papers

No abstract provided.

Living Evidence-Informed Guideline On The Early Detection Of Oral Squamous Cell Carcinoma And Potentially Malignant Disorders: Cytology Adjuncts To Determine The Need For Biopsy, Version 2026 1.0, James C Melville, Anita S H Patel, Alessandro Villa, Michael Glick, Mark W Lingen

Faculty, Staff and Student Publications

Background: Early detection of oral potentially malignant disorders and oral cavity cancer can improve patient prognosis. The guideline panel addressed the use of cytology adjuncts to screen adults without mucosal abnormalities and determine the need for biopsy among adults with mucosal abnormalities.

Types of studies reviewed: The guideline panel used the Grading of Recommendations Assessment, Development and Evaluation Evidence to Decision framework to formulate recommendations. The authors conducted reviews to assess the benefits and harms of cytology adjuncts and people and clinician values and preferences as they relate to adjunct tests and biopsy of mucosal abnormalities. As part of the …

Histologic Analysis Of Peri-Implant Soft Tissue Around External Hexagon And Morse Taper Implant Connections

Faculty, Staff and Student Publications

Background: Twenty patients rehabilitated with screw-retained full-arch implant-supported prostheses functioning for at least one year were included.

Material and methods: This clinical study included 20 patients rehabilitated with screw-retained full-arch implant-supported prostheses in function for at least 1 year. Participants were allocated into two groups according to the implant-abutment connection design: external hexagon (EH; n = 10) and Morse taper (MT; n = 10). One peri-implant soft tissue biopsy specimen was obtained from each patient and processed for hematoxylin-eosin staining. Histological evaluation assessed epithelial hyperplasia, epithelial organization, inflammatory infiltrate intensity, and connective tissue fibrosis. Data normality was assessed using the …

Evaluating Icd-11 Against Established Terminology Standards: A Dual-Framework Analysis

Faculty, Staff and Student Publications

Background

The healthcare world is evaluating and adopting the World Health Organization’s (WHO’s) International Statistical Classification of Diseases and Related Health Problems Eleventh Revision (ICD-11) for Mortality and Morbidity Statistics (MMS). The objective of this study is to evaluate the degree to which the ICD-11 Foundation and the ICD-11 MMS linearization adhere to accepted terminology practices.

Methods

This study consisted of an evaluation of the ICD-11 Foundation and ICD-11 MMS, using two established evaluation frameworks. Initial assessments were independently evaluated using publicly available documentation and designated one of five endpoints: meets criterion, partially meets criterion, does not meet criterion, criterion …

Real-World Effectiveness Of Second-Line Therapies In Advanced Non-Small Cell Lung Cancer: Insights From Propensity-Weighted Comparative Analyses Of Longitudinal Ehr Data

Faculty, Staff and Student Publications

Background: While substantial research has focused on first-line (1L) therapies for advanced-stage non-small cell lung cancer (aNSCLC), less is known about the effectiveness of second-line (2L) treatments following disease progression on 1L. The poor prognosis after 1L progression, limited guidance for 2L treatment, and constraints of clinical trials in addressing these questions underscore the need for real-world comparative effectiveness research.

Methods: We conducted a retrospective analysis to compare real-world overall survival (rwOS) associated with 2L treatments among patients with disease progression during 1L. Eligible patients were selected from Flatiron Health's nationwide electronic health record (EHR)-derived de-identified database. 1L and 2L …

Global, Regional, And National Burden Of Breast Cancer Among Females, 1990–2023, With Forecasts To 2050: A Systematic Analysis For The Global Burden Of Disease Study 2023, Gbd 2023 Breast Cancer Collaborators Breast Cancer Collaborators, Kathryn H. Jacobsen

Health Studies Faculty Publications

Summary

Background

Methods

The Correlation Of Vitamin D Deficiency On Clinical Disease Activity Index (Cdai) Scores In Patients With Rheumatoid Arthritis, Ruha Reddy, Amanda Rodriguez Do, Amy Wu, Jasmine Sturn, Rachel Champagne, Rebekah Johnson, Marie S. O'Brien Do

USF-LVHN SELECT

No abstract provided.

Association Between Infection With Multidrug Resistant Staphylococcus Aureus And Patient Risk Factors, Ariana Virgillio, Emily A. Felton, Josh Alvior, Abigail Eglinton, Deanna N. Becker, Amorce Lima, E Cella, T Azarian, Suzane Silbert, Lindsey N. Shaw, Kami Kim

USF-LVHN SELECT

No abstract provided.

Lehigh County Harm Reduction Women’S Outreach, Linda Schiller, Abby S. Letcher Md, Nyann Biery Ms, Heather Diehl, Carnen Ortiz, Bryant Rivera, William Delgado

USF-LVHN SELECT

No abstract provided.

A Comparative Operational Analysis Of Patient Access And Clinician Productivity: Identifying Success Drivers In Pediatric Gastroenterology, Lionel Sam, Liborio Larussa Md

USF-LVHN SELECT

No abstract provided.

Youth Suicide Across The Lehigh Valley Health Network Region:Determining Common Lethal Means Used Locally, Madeline Pollak, Emmanuel Annor Md, Rebecca Lipscomb, Dhanalakshmi Ramasamy Md

USF-LVHN SELECT

No abstract provided.

Characterization Of Transgender Men Undergoing Hysterectomy At The Lehigh Valley Health Network, Christine Peng, Shae Duka Mph, Patricia L. Mara Md

USF-LVHN SELECT

No abstract provided.

An Assessment Of Brain Mri Utilization In Inpatient Admissions For Headache And Dizziness At Lehigh Valley Health Network, Srijit Paul, Shadi Jarjous Md

USF-LVHN SELECT

No abstract provided.

Real-World Challenges Associated With Assembling Multicenter Radiomics Dataset, Wai Lone Jonathan Ho, Lawrence O. Hall, Dmitry Goldgof, Matthew B. Schabath

USF-LVHN SELECT

No abstract provided.

Patient Education Quality Improvement Initiative On Common Neuro Ophthalmology Diagnoses, Rithvic Jupudi, Casey Judge Do, Negar Moheb Md

USF-LVHN SELECT

No abstract provided.

Ulcerative Colitis Predominates, Yet Hepatic Progression Mirrors Crohn’S In Primary Sclerosing Cholangitis–Inflammatory Bowel Disease Overlap: A Tertiary Cohort Study, Sunny Kahlon, Megan Pearce, Donna Ortiz, Jennifer Seminerio

USF-LVHN SELECT

No abstract provided.

Safer Opioid Prescribing Practices In Pediatric Surgery:A Multi-Specialty Initiative To Implement Evidence-Based Pain Management Strategies, Grace Lee, Carly Miller, Rebecca Lipscomb, Amy L. Serfas Bsn, Rn, Marybeth Browne Md

USF-LVHN SELECT

No abstract provided.

Single-Cell Multi-Omic Techniques Highlight The Diverse Composition And Intercellular Interactions Of The Vestibular Schwannoma Tumor Microenvironment, Shree S Pari, Sangami Pugazenthi, Albert H Kim, Bhuvic Patel

2020-Current year OA Pubs

Vestibular schwannomas (VS) are tumors arising from Schwann cells of the vestibulocochlear nerve, often leading to hearing loss, gait imbalance, and other neurological complications. Recently, molecular profiling of VS using bulk and single-cell transcriptional and epigenetic approaches has reshaped our understanding of VS pathogenesis and challenged the long-standing view of VS being molecularly homogeneous. These integrative, multi-omic approaches reveal significant differences within VS and highlight diverse Schwann cell subpopulations and their interactions with the tumor microenvironment. Interestingly, these analyses also uncover 2 molecularly distinct groups of VS, one containing Schwann cells with an "Injury-like" phenotype that drives VS progression through …

Bacterial Immune Activation Via Supramolecular Assembly With Phage Triggers, Tong Zhang, Yifei Lyu, Christina R Beck, Naseer Iqbal, Renee Barbosa, Alireza Ghanbarpour, Michael T Laub

2020-Current year OA Pubs

Bacteria use diverse mechanisms to protect themselves against phages

The Win Ratio For Evaluating Edoxaban Vs Dalteparin For Cancer-Associated Venous Thromboembolism: An Analysis Of The Randomized Hokusai Venous Thromboembolism Cancer Trial, Nick Van Es, Luuk J J Scheres, Kristen M Sanfilippo, Harry Büller, Marc Carrier, Marcello Di Nisio, Michael Grosso, Renato D Lopes, William F Mcintyre, Bjorn Redfors, Annelise Segers, Peter Verhamme, Jeffrey I Weitz, Patrick M Bossuyt, Deborah M Siegal

2020-Current year OA Pubs

BACKGROUND: The Hokusai Venous Thromboembolism (VTE) Cancer trial demonstrated that edoxaban was noninferior to dalteparin for the treatment of cancer-associated venous VTE.

OBJECTIVES: We reanalyzed the trial using the win ratio, an approach that evaluates a composite of outcomes in a hierarchical order.

METHODS: Forty-nine thrombosis experts ranked 10 outcomes in order of clinical importance from all-cause death (most important) to clinically relevant nonmajor bleeding (least important). We performed unmatched pairwise comparisons between participants on edoxaban and those on dalteparin at 6- and 12-month follow-up. Within each pair, edoxaban was assigned a win, loss, or tie according to the hierarchy …

Durability Of Efficacy, Safety, And Quality Of Life 5 Years After Valoctocogene Roxaparvovec Gene Transfer For Severe Hemophilia A: Final Phase 3 Gener8-1 Trial Results, Andrew D Leavitt, Elaine Majerus, Et Al.

2020-Current year OA Pubs

BACKGROUND: Valoctocogene roxaparvovec, a gene therapy for severe hemophilia A, enables endogenous factor VIII (FVIII) expression and confers bleed control.

OBJECTIVES: To present the final 5-year efficacy and safety results from the phase 3 GENEr8-1 trial.

METHODS: Adult men (

RESULTS: Median follow-up was 261.1 weeks; 128 of 134 participants completed the study. For the 112 participants who enrolled from a previous noninterventional study (rollover population), mean ABR for treated bleeds declined by 83.3% (

CONCLUSION: Valoctocogene roxaparvovec provides durable hemostatic efficacy, FVIII activity, and improved health-related quality of life for ≥5 years, with no new safety signals.

Evolving Landscape Of Respiratory Infections And Amr In The Uae: A 12-Year Nationwide Study Of Regional Burden, Epidemiologic Trends And Policy Implications, Madikay Senghore, Jens Thomsen, Najiba M. Abdulrazzaq, Wei Chen, Eveline Kaambo, Stefan Weber, Fouzia Jabeen, Godfred Antony Menezes, Carole Ayoub Moubareck, Dean B. Everett, Abiola Senok

All Works

Objectives This study characterizes the epidemiological trends and resistance profiles of respiratory tract infections (RTIs) in the United Arab Emirates (UAE) from 2010 to 2022, aiming to inform national control strategies. Method We conducted a retrospective observational study of RTI cases across 345 UAE healthcare settings using data from the national surveillance network. Pathogen identification and resistance profiling were performed using advanced diagnostics and standardized antimicrobial susceptibility testing, in accordance with Clinical and Laboratory Standards Institute (CLSI) guidelines. Results Lower respiratory tract infections (LRI) comprised most cases (73.1%; n = 100,856), including 6416 due to Mycobacterium tuberculosis , while upper …

A Comprehensive Biomechanical Material Characterization Of The Human Breast Fibro-Structural Support System, Aroj Bhattarai, Gregory P Reece, Kristy K Brock, Krishnaswamy Ravi-Chandar

Faculty, Staff and Student Publications

Breast surgery for aesthetic purposes, such as breast augmentation or breast reduction, and breast reconstruction after cancer treatment require an accurate structural (anatomical) and mechanical (functional) understanding of the breast components, including the fascial-ligamentous support system of the breast, to achieve optimal results. This paper aims to provide a comprehensive description of the mechanical behavior of the ligamentous and fascial connective tissues of the human female breast. Fasciae and ligaments obtained from 17 patients between 35 and 85 years of age who were undergoing mastectomy and three female cadavers were tested. Uniaxial tensile tests were conducted, and three constitutive models …

Improving Vaccination In People With Ckd: Report From A National Kidney Foundation Working Group, Susan F. Massengill, Kenneth A. Andreoni, Keith A. Bellovich, Cheryl Courtlandt, Vimal K. Derebail, David L. Feldman, Gia J. Oh, John W. Sleasman, Kristina A. Bryant, Improving Vaccination In Ckd Working Group

Department of Surgery Faculty Papers

People with chronic kidney disease (CKD) are particularly vulnerable to vaccine-preventable infections. Therefore, the National Kidney Foundation organized a multidisciplinary working group, including people with CKD and family care partners, to develop recommendations to improve vaccination rates, vaccination effectiveness, and health care for the CKD population. A modified Delphi process was used to achieve consensus on the recommendations. Recommendations on vaccination in CKD patients were organized into these categories: (1) patient preferences; (2) assessing the vaccination status of patients with CKD; (3) assessing vaccine response in patients with CKD; (4) vaccination of immunocompromised patients; (5) vaccination in posttransplant patients; (6) …

A Physician Survey On Research And Implementation Priorities For Caffeine Citrate Use In Newborn Care In Sub-Saharan Africa, Olufunke Bolaji, Osayame Ekhaguere, Franck Houndjahoue, Nicholas Embleton, Helen Nabwera

Centre of Excellence in Women and Child Health

Background:Evidence on caffeine citrate (CC) for apnoeaof prematurity (AOP) originate from high-income countries. This study aimed to develop consensus on research design for evidence in sub-Saharan Africa (SSA).

Methods:We surveyed physicians in newborn units across SSA to assess their opinions on CC research and their preferred study designs.

Participants rated four study designs:a) an observational before-and-after study; a randomized controlled trial (RCT) of b) caffeine versus placebo; c) caffeine versus aminophylline; d) a traditional or stepped wedge cluster trial.  They  assessed  each  design  using  a  Likert  scale  for  evidence, feasibility, and ethics considerations.

Results:Ninety-two   newborn   physicians …

Adapting Lessons From The Indian Subcontinent To Accelerate Elimination Of Visceral Leishmaniasis As A Public Health Problem In East Africa, Eva Iniguez, Daniel Masiga, Caryn Bern, Sridhar Srikantiah

All Peer-Reviewed Publications

This viewpoint draws lessons from the elimination of visceral leishmaniasis (VL) as a public health problem in the Southeast Asia region (SEAR) to inform efforts in East Africa (EA), now the global epicenter of Leishmania donovani transmission. VL is fatal and there is no licensed vaccine. Success in India relied on robust surveillance, rapid diagnosis, single-dose treatment, vector control, and multi-partner coordination. EA faces additional challenges than SEAR with multiple sand fly vectors, sensitive diagnostics and longer treatment regimens, high population mobility, and gaps in ecological and epidemiological knowledge. We highlight how strategies from South Asia could be adapted while …

Orthopedic Bone Drill, Logan G. Schmid, Matthew T. Wold, May Geng

Biomedical Engineering

This project aims to design a bone drill for orthopedic procedures which alleviates the heat generated in the bone during drilling.

Entangled Transitions: How Covid-19 Widened Well-Being Gaps Among Youth In Singapore (2017–2022), Vincent Chua, Han Ei Chew, Isabelle Tan, Pamela Lee

Research Collection Office of Impact

COVID-19 was not merely a biomedical crisis but a deeply social phenomenon entangled with existing inequalities. Drawing on Peter Kelly's notion of entanglement, we conceptualise the pandemic as an intersectional crisis − where time, structural disadvantage and socio-emotional well-being became interwoven. Using six waves of longitudinal data (2017–2022) from Youth STEPS, a panel study of young people in Singapore, we track within-person changes in life satisfaction across key youth transitions before, during and after the pandemic. Our findings show that the negative effects of unemployment and insecure work on well-being were markedly more severe during the pandemic than in earlier …