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Articles 10621 - 10650 of 325134

Full-Text Articles in Medicine and Health Sciences

Post-Induction Minimal Residual Disease Study By Flow Cytometry In Pediatric B All And Its Correlation With Initial Clinical And Laboratory Parameters, Huda Ali Alnaseri, Yassmin Ali Alaamiri, Hussam Mahmood Salih Jan 2026

Post-Induction Minimal Residual Disease Study By Flow Cytometry In Pediatric B All And Its Correlation With Initial Clinical And Laboratory Parameters, Huda Ali Alnaseri, Yassmin Ali Alaamiri, Hussam Mahmood Salih

Iraqi National Journal of Medicine

Background: Acute lymphoblastic leukemia (ALL) is a cancer characterized by the rapid and uncontrolled growth of immature lymphoid cells. Among its subtypes, B-lineage ALL in children represents the most frequently diagnosed malignancy in the pediatric population. Despite high survival rates, relapsed or refractory cases remain challenging. Minimal Residual Disease (MRD), detected by flow cytometry, is a strong prognostic marker that guides the intensity of post-induction therapy. Aim: This study aims to evaluate the correlation between post-induction MRD, measured by multicolor flow cytometry, and the initial clinical and laboratory parameters in pediatric patients with B-ALL. Methods: A retrospective cross-sectional study was …


Psychiatric Disorders Among Divorced People In Basrah, Jamal Abdulzahra, Rafal W. Khalid, Aqeel Ibraheem Al-Sabbagh Jan 2026

Psychiatric Disorders Among Divorced People In Basrah, Jamal Abdulzahra, Rafal W. Khalid, Aqeel Ibraheem Al-Sabbagh

Iraqi National Journal of Medicine

Background: Divorce has been linked to increased psychiatric morbidity; however, studies in regions such as Iraq remain sparse. Despite the known mental health challenges that often follow divorce, the impact within the Iraqi context—shaped by unique cultural changes—demands focused exploration. Aim: This study aimed to estimate the prevalence of psychiatric morbidity among divorced individuals, identify psychiatric disorders post-divorce, and assess the impact of various sociodemographic variables on psychiatric morbidity in this population. Methods: Employing a case-control design, this study was conducted in collaboration with local courts and psychiatric clinics in Basrah. A total of 154 participants, divided equally between divorced …


Clinical Evaluation Of Intraoperative Indocyanine Green (Icg) Fluorescent Cholangiography During Laparoscopic Cholecystectomy: A Comparative Study, Mariam Akeel, Issam Al-Najjari, Ali Dawood Jan 2026

Clinical Evaluation Of Intraoperative Indocyanine Green (Icg) Fluorescent Cholangiography During Laparoscopic Cholecystectomy: A Comparative Study, Mariam Akeel, Issam Al-Najjari, Ali Dawood

Iraqi National Journal of Medicine

Background: Laparoscopic cholecystectomy (LC) is one of the most common surgical procedures performed globally. While it is generally considered safe, there remains a risk of serious biliary injuries occurring during the procedure. Indocyanine green (ICG) is a water-soluble, non-toxic dye that allows real-time intraoperative visualization of the extrahepatic biliary tree. Aim: This study aims to compare the bile duct injury rate, duration of surgery, conversion rate, length of hospitalization, and overall outcomes between laparoscopic cholecystectomy with and without indocyanine green (ICG).  Methods: Ninety-two patients who underwent LC from October 2023 to October 2024 were included in the study; 42 of …


Levels Of 8-Isoprostane And Advanced Oxidation Protein Products In Relation To Sperm Count And Motility, Ahmed Sulaiman, Sherwan Salih Jan 2026

Levels Of 8-Isoprostane And Advanced Oxidation Protein Products In Relation To Sperm Count And Motility, Ahmed Sulaiman, Sherwan Salih

Iraqi National Journal of Medicine

Background: Oxidative stress is implicated in male infertility, with reactive oxygen species contributing to sperm dysfunction. Among oxidative stress markers, 8-isoprostanes (8-isoP) and advanced oxidation protein products (AOPP) serve as indicators of lipid peroxidation and protein oxidation, respectively. However, their relationship with specific sperm abnormalities remains unclear. Aim: This study investigates the oxidative stress markers 8-isoprostane (8-isoP) and advanced oxidation protein products (AOPP) across different semen profiles and explores their correlation with sperm count and motility to evaluate their potential as diagnostic biomarkers in male infertility. Methods: A cross-sectional study was conducted on male partners of infertile couples between May …


Serum Iron Profile In Sudanese Patients Infected By Helicobacter Pylori, Rimaz Gurashi, Abuagla M. Dafalla, Suhair A. Ahmed, Shereen Faisal, Abdelkarim A. Abdrabo Jan 2026

Serum Iron Profile In Sudanese Patients Infected By Helicobacter Pylori, Rimaz Gurashi, Abuagla M. Dafalla, Suhair A. Ahmed, Shereen Faisal, Abdelkarim A. Abdrabo

Iraqi National Journal of Medicine

Background: Helicobacter pylori is a Gram-negative, spiral-shaped, motile bacterium that represents one of the most widespread chronic infections in humans, affecting nearly half of the global population. Iron is a vital micronutrient required for almost all living organisms, including H. pylori, which relies on iron to establish colonization. Although several studies have indicated an association between iron deficiency (ID) or iron deficiency anemia (IDA) and H. pylori infection, the precise mechanisms remain incompletely understood. Aim: To assess the serum iron profile among Sudanese patients with H. pylori infection. Methods: Analytical case‑control hospital-based study was conducted at Bahri Hospital, Khartoum state …


Measles Outbreak In Anbar Province During 2023-2024. Demographic Distribution And Vaccination Status, Rafi Alani, Mohammed Dawood Jan 2026

Measles Outbreak In Anbar Province During 2023-2024. Demographic Distribution And Vaccination Status, Rafi Alani, Mohammed Dawood

Iraqi National Journal of Medicine

Background: This is the first public study covering all cities in Anbar Province regarding the measles outbreaks occurred in 2023 and 2024. Aim: To estimate the demographic distribution of measles among infected children (age, gender, residence) in Anbar Province and to study the effectiveness of the measles vaccine for each patient on infection. Methods: A retrospective analytic cross-sectional study was conducted across all sectors of Anbar Province. The patients included those who were admitted, diagnosed, and treated in various hospitals during the measles outbreak in 2023, and 2024 years. The data was recorded in files of the Anbar Public Health …


Association Of Matricellular Protein, Growth Factor, And Transcription Factor With Molecular Subtypes Of Breast Cancer: A Case Control Study, Marwa Munther Homman, Eman Tariq Ali, Maitham Ali Alrikabi Jan 2026

Association Of Matricellular Protein, Growth Factor, And Transcription Factor With Molecular Subtypes Of Breast Cancer: A Case Control Study, Marwa Munther Homman, Eman Tariq Ali, Maitham Ali Alrikabi

Iraqi National Journal of Medicine

Background: Breast cancer is a heterogeneous disease comprising molecular subtypes such as Luminal A, Luminal B, Human Epidermal Growth Factor 2 (HER-2)-Enriched, and Triple Negative, each with distinct clinical, molecular, and immunological features. Immunological markers play a critical role in modulating tumor behavior, angiogenesis, and immune evasion. Aim: This study aimed to identify key immunological markers that correlate with the molecular (intrinsic) subtypes of breast cancer and to explore their potential as prognostic factors. Methods: Serum samples from 180 breast cancer patients (56 untreated and 74 treated) were analyzed using Enzyme-Linked Immunosorbent Assay (ELISA) to determine the levels of four …


Corrigendum: Prevalence Of High Tricuspid Regurgitation Jet Velocity In Patients With Sickle Cell Disease, Amer Al Mansory Jan 2026

Corrigendum: Prevalence Of High Tricuspid Regurgitation Jet Velocity In Patients With Sickle Cell Disease, Amer Al Mansory

Iraqi National Journal of Medicine

Post-publication Author Correction Following publication of the above article, the Editorial Office of the Iraqi National Journal of Medicine (IqNJM) received a formal request on 7 July 2025 from Dr. Assad Faisal Al-Kuheli requesting a correction to the authorship of the article, including removal of one author and rearrangement of the author sequence. Upon receipt of this request, the Editor-in-Chief initiated a formal investigation in accordance with the journal’s bylaws and authorship correction policy. As part of this process, Dr. Weal Al-Shehaby and the Editor-in-Chief contacted all originally listed authors as well as the newly proposed author, both directly by …


Re: Utility Of Routine 24-Hour Electrocardiographic Holter Monitoring For Detecting Atrial Fibrillation In Patients Admitted With Acute Stroke Syndromes, Sinda Zarrouk, Josef Finsterer Jan 2026

Re: Utility Of Routine 24-Hour Electrocardiographic Holter Monitoring For Detecting Atrial Fibrillation In Patients Admitted With Acute Stroke Syndromes, Sinda Zarrouk, Josef Finsterer

Sultan Qaboos University Medical Journal

No abstract provided.


The Impact Of Indigenous American-Like Ancestry On The Risk Of Acute Lymphoblastic Leukemia In Hispanic/Latino Children, Jalen Langie, Tsz Fung Chan, Wenjian Yang, Alice Y Kang, Libby Morimoto, Daniel O Stram, Nicholas Mancuso, Xiaomei Ma, Catherine Metayer, Philip J Lupo, Karen R Rabin, Michael E Scheurer, Joseph L Wiemels, Jun J Yang, Adam J De Smith, Charleston W K Chiang Jan 2026

The Impact Of Indigenous American-Like Ancestry On The Risk Of Acute Lymphoblastic Leukemia In Hispanic/Latino Children, Jalen Langie, Tsz Fung Chan, Wenjian Yang, Alice Y Kang, Libby Morimoto, Daniel O Stram, Nicholas Mancuso, Xiaomei Ma, Catherine Metayer, Philip J Lupo, Karen R Rabin, Michael E Scheurer, Joseph L Wiemels, Jun J Yang, Adam J De Smith, Charleston W K Chiang

Faculty, Staff and Students Publications

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, with Hispanic/Latino children having a higher incidence of ALL than other racial/ethnic groups. Among the genetic variants previously implicated in ALL risk, a number of them were found to be enriched in Indigenous American (IA)-like ancestries and inherited by many Hispanic/Latino individuals. However, due to potential confounding from environmental factors, the association between IA-like ancestry and risk for ALL has remained unclear. In this study, we characterized the impact of IA-like ancestry on overall ALL risk and on the frequency and effect size of known risk alleles, while accounting for …


Epigenome-Wide Association Study Meta-Analysis Of Bmi In African Americans, Kendra Ferrier, Mariaelisa Graff, Iain R Konigsberg, Maggie Stanislawski, Heather M Highland, Laura M Raffield, April P Carson, Eric Boerwinkle, Jill M Norris, Chris R Gignoux, Audrey E Hendricks, Sridharan Raghavan, Kari E North, Kristin L Young, Anne E Justice, Matthew A Allison, Mathew J Budoff, Silva Kasela, François Aguet, Joshua J Joseph, Charles Kooperberg, Stephen S Rich, Jerome I Rotter, Ethan M Lange, Leslie A Lange Jan 2026

Epigenome-Wide Association Study Meta-Analysis Of Bmi In African Americans, Kendra Ferrier, Mariaelisa Graff, Iain R Konigsberg, Maggie Stanislawski, Heather M Highland, Laura M Raffield, April P Carson, Eric Boerwinkle, Jill M Norris, Chris R Gignoux, Audrey E Hendricks, Sridharan Raghavan, Kari E North, Kristin L Young, Anne E Justice, Matthew A Allison, Mathew J Budoff, Silva Kasela, François Aguet, Joshua J Joseph, Charles Kooperberg, Stephen S Rich, Jerome I Rotter, Ethan M Lange, Leslie A Lange

Faculty, Staff and Student Publications

Despite considerable advances in identifying risk factors for obesity, gaps remain in our understanding about its etiology. Genetic variants explain only a small portion of variation in obesity-related traits such as body mass index (BMI). Epigenetic regulation, which controls gene expression and is influenced by environmental and genetic factors, may account for additional variability in BMI. Epigenetic studies of BMI have largely been conducted in European ancestry populations, despite the disproportionate burden of obesity in African Americans (AAs). We conducted a sex-stratified BMI epigenome-wide association study meta-analysis in AA participants from the Jackson Heart Study (n = 1,604) and …


Dna Methyltransferase Inhibitors In Hematological Malignancies And Solid Tumors, Valentin Wenger, Guillermo Garcia-Manero, Robert Zeiser, Michael Lübbert Jan 2026

Dna Methyltransferase Inhibitors In Hematological Malignancies And Solid Tumors, Valentin Wenger, Guillermo Garcia-Manero, Robert Zeiser, Michael Lübbert

Faculty, Staff and Student Publications

Epigenetic modifications such as DNA methylation play a fundamental role in oncogenesis and the progression of neoplasms neoplasias. DNA methyltransferase inhibitors (DNMTi) constitute a family of therapeutic agents that impede the methylation at the 5-position on cytosine nucleotides, thereby modulating the epigenetic regulation of tumor suppressor genes, oncogenes, and other key regulatory genes. The first-generation DNMTi azacitidine and decitabine have demonstrated substantial efficacy in the treatment of medically non-fit, older patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) ineligible for intensive chemotherapy (IC), by virtue of their favorable safety profile. Despite these clinical achievements, however, single-agent DNMTi treatment …


C Elegans As A Tractable Infection Model For The Emerging Fungal Pathogen Candida Auris, Melissa Martinez, Melissa R Cruz, Danielle A Garsin, Michael C Lorenz Jan 2026

C Elegans As A Tractable Infection Model For The Emerging Fungal Pathogen Candida Auris, Melissa Martinez, Melissa R Cruz, Danielle A Garsin, Michael C Lorenz

Faculty, Staff and Student Publications

Candida auris is an emerging multidrug-resistant fungal pathogen. The genetic factors contributing to the virulence, drug resistance, and stress-tolerant nature of C. auris are mostly unknown. Additional animal models of virulence are needed, especially those amenable to high-throughput analysis. The nematode Caenorhabditis elegans has been validated as an effective tool for studying multiple fungal and bacterial pathogens. We describe here a C. elegans infection model in which exposure to C. auris is lethal to worms with kinetics similar to killing by Candida albicans; in contrast to C. albicansC. auris does not form hyphae, indicating distinct virulence mechanisms. …


Unilateral Cervical Spine Facet Fractures: Radiographic Predictors Of Instability, Erisha Tashakori, Reese Svetgoff, Jacob Siahaan, Norman Zheng, Nicholas Beckmann, James Showery, Ran Lador, Mark L Prasarn Jan 2026

Unilateral Cervical Spine Facet Fractures: Radiographic Predictors Of Instability, Erisha Tashakori, Reese Svetgoff, Jacob Siahaan, Norman Zheng, Nicholas Beckmann, James Showery, Ran Lador, Mark L Prasarn

Faculty, Staff and Student Publications

Study design: Retrospective cohort study.

Objective: The purpose of our study is to identify CT characteristics of unilateral cervical spine facet fractures that are predictive of instability on MRI.

Summary of background data: Management of isolated subaxial cervical spine facet fractures is typically based on the neurological status of the patient and perceived stability of the injury. It has been shown that the degree of ligamentous instability can help predict instability and need for surgery, and MRIs are increasingly being used to evaluate these injuries, but not always. While there are studies that evaluate radiographic characteristics of facet fractures on …


Bdcd: A Comprehensive Brain Disease Cell-Cell Communication Database, Xinyi Liu, Citu Citu, Gang Qu, Wendao Liu, Nitesh Enduru, Andi Liu, Chia-Hao Tung, Zhongming Zhao Jan 2026

Bdcd: A Comprehensive Brain Disease Cell-Cell Communication Database, Xinyi Liu, Citu Citu, Gang Qu, Wendao Liu, Nitesh Enduru, Andi Liu, Chia-Hao Tung, Zhongming Zhao

Faculty, Staff and Student Publications

Dysregulated cell–cell communication (CCC) is increasingly recognized as a driver of brain disease pathology, contributing to neuroinflammation, synaptic dysfunction, and neurodegeneration. Nevertheless, existing resources remain limited in brain specificity, regional coverage, and functional annotation. To address this gap, we develop the Brain Disease Cell-cell communication Database (BDCD), the first comprehensive resource focused on CCC networks across major brain diseases. BDCD integrates 38 manually curated datasets, comprising 8 519 425 single cells from single-cell RNA-seq studies and 140 744 spots from spatial transcriptomic maps, spanning 14 brain regions and 13 canonical cell types covering Alzheimer’s disease, Parkinson’s disease, schizophrenia, bipolar disorder, …


Serendipity In Psychiatric Discoveries: Historical Lessons And Future Imperatives For Clinical Observation, Stanley Lyndon, Vineeth P John Jan 2026

Serendipity In Psychiatric Discoveries: Historical Lessons And Future Imperatives For Clinical Observation, Stanley Lyndon, Vineeth P John

Faculty, Staff and Student Publications

Aims and method: Serendipity has driven many of psychiatry's most important treatments, yet contemporary systems may undermine clinicians' ability to notice and develop unexpected therapeutic effects. This selective narrative review synthesises landmark discovery stories, conceptual accounts of serendipity and contemporary case examples to clarify how chance observations become robust advances.

Results: Across historical and modern examples, serendipitous discoveries consistently reflected the interaction of unexpected events with prepared observers working in supportive institutional and research systems. We identify current barriers created by standardised care, funding and trial structures, and professional fragmentation, and outline a multi-level framework for cultivating serendipity through phenomenological …


Bridging Hypoxia And Vision Loss: The Emerging Role Of Connexins In Local And Systemic Eye Diseases, Xianping Zhang, Yalong Cheng, Jean X Jiang, Yuting Li Jan 2026

Bridging Hypoxia And Vision Loss: The Emerging Role Of Connexins In Local And Systemic Eye Diseases, Xianping Zhang, Yalong Cheng, Jean X Jiang, Yuting Li

Faculty, Staff and Student Publications

Hypoxic eye diseases represent a pivotal yet often underappreciated contributor to the onset and progression of many retinal disorders. When hypoxia persists or exceeds the tissue's compensatory capacity, it triggers pathological retinal neovascularization, blood-retinal barrier disruption, and neuronal apoptosis, ultimately resulting in irreversible visual impairment. Connexins (Cxs) form gap junction channels and hemichannels and regulate retinal cell proliferation, differentiation, and survival, thereby playing a central regulatory role in the pathogenesis of hypoxic ocular diseases. In addition to gap junctions, Cx hemichannels promote transmission of molecules between intra- and extracellular environments, further influencing retinal homeostasis under hypoxic stress. This review synthesizes …


Retention On Buprenorphine For Opioid Use Disorder In Justice-Involved Individuals: A Retrospective Cohort Study, Andrea Yatsco, Francine R Vega, Audrey Sarah Cohen, Marylou Cardenas-Turanzas, James R Langabeer, Tiffany Champagne-Langabeer Jan 2026

Retention On Buprenorphine For Opioid Use Disorder In Justice-Involved Individuals: A Retrospective Cohort Study, Andrea Yatsco, Francine R Vega, Audrey Sarah Cohen, Marylou Cardenas-Turanzas, James R Langabeer, Tiffany Champagne-Langabeer

Faculty, Staff and Student Publications

Criminal justice system (CJS) involvement is common among individuals with opioid use disorder (OUD), yet limited research examines retention in medications for OUD (MOUD) within community settings. This study assessed whether CJS involvement predicted retention on buprenorphine/naloxone and explored related demographic and clinical factors. A retrospective cohort included adults (n = 367) enrolled in a low-barrier outpatient MOUD program in Texas (January 2022–April 2024). CJS involvement was identified from program records. Retention was measured as the number of continuous days with buprenorphine/naloxone prescriptions. Analyses used univariate tests, logistic regression, and nonparametric kernel regression. Nearly one-quarter (24.8%) were CJS-involved. Retention at …


Epilepsy Disease Classification: A Community Effort To Enhance The Mondo Disease Ontology, Nicole Vasilevsky, Sarah Gehrke, Kathleen Mullen, Subit Barua, Ian Braun, Tobias Brünger, Curtis Coughlin, Alina Ivaniuk, Daniel Korn, Dennis Lal, Stephanie Marsh, Elaine O'Loughlin, Daniel Olson, Yousif Shwetar, Christalena Sofocleous, Vanessa Vogel-Farley, Heidi Grabenstatter, Melissa Haendel, Christopher Mungall, Sabrina Toro Jan 2026

Epilepsy Disease Classification: A Community Effort To Enhance The Mondo Disease Ontology, Nicole Vasilevsky, Sarah Gehrke, Kathleen Mullen, Subit Barua, Ian Braun, Tobias Brünger, Curtis Coughlin, Alina Ivaniuk, Daniel Korn, Dennis Lal, Stephanie Marsh, Elaine O'Loughlin, Daniel Olson, Yousif Shwetar, Christalena Sofocleous, Vanessa Vogel-Farley, Heidi Grabenstatter, Melissa Haendel, Christopher Mungall, Sabrina Toro

Faculty, Staff and Student Publications

Motivation: Epilepsy is a diverse group of neurological disorders affecting over 50 million people worldwide. While common epilepsy types are well studied, rare epilepsies-often severe and genetically complex-pose significant challenges in diagnosis, research, and treatment. Accurate and interoperable etiology and disease classifications are critical for improving data sharing, supporting clinical decision-making, and advancing rare disease research.

Results: To enhance the accuracy of epilepsy-related disease concept representation within the Mondo Disease Ontology (Mondo), we conducted a series of expert-driven workshops in collaboration with the team from the Rare Disease Cures Accelerator-Data and Analytics Platform (RDCA-DAP). Specialists in epileptology, genetics, neurodevelopment, biomedical …


A196: Prediction Of Cardiovascular Function Improvement Based On Wearable Device Motion Monitoring And Otnmanba-Bilstm Model, Yixuan Li, Lan Zheng Jan 2026

A196: Prediction Of Cardiovascular Function Improvement Based On Wearable Device Motion Monitoring And Otnmanba-Bilstm Model, Yixuan Li, Lan Zheng

International Journal of Physical Activity and Health

Cardiovascular diseases are among the leading chronic health conditions worldwide, with prolonged physical inactivity or improper exercise increasing the risk of their occurrence. Existing studies suggest that well-structured exercise interventions can significantly enhance cardiac function and improve the adaptability of the cardiovascular system. However, accurately predicting the long-term impact of different exercise durations and intensities on heart health remains challenging due to individual physiological differences, exercise habits, and lifestyle factors. This study employs a data-driven approach to develop a predictive model based on wearable device motion monitoring data, aiming to elucidate the dynamic relationship between exercise and cardiovascular health and …


A197: Perceptual Behavior And Social Interaction Of Chinese College Students Toward Esports, Xianhua Luo Jan 2026

A197: Perceptual Behavior And Social Interaction Of Chinese College Students Toward Esports, Xianhua Luo

International Journal of Physical Activity and Health

Social exchange theory (SET) has been extensively used to recognize students’ perceptual behavior (PB) and social interaction (SI). Research has examined the potential factors of recognition and socialization against the economic factors in individual evaluation, seeking rewards or avoiding costs in relationships. The positive impact of PB and SI is a significant experimental approach to studying social psychology. Therefore, the processes of individuals’ perceptual behavior and their social interactions in Esports might address this research gap. Hence, the purposes of this study were to explain the PBs and SIs toward Esports among college students in China. Method: 341college students were …


A214: Effects Of Tai Chi And Brisk Walking On Sensation In Pn Elders, Qiongqiu Zhao, Qipeng Song Jan 2026

A214: Effects Of Tai Chi And Brisk Walking On Sensation In Pn Elders, Qiongqiu Zhao, Qipeng Song

International Journal of Physical Activity and Health

Peripheral neuropathy (PN) is a prevalent neurological disorder, affecting 26–39.2% of adults aged 65 and older due to peripheral nerve degeneration and associated conditions like diabetes. PN leads to sensory impairments, including diminished tactile sensation, increased fall risk, and mobility issues. Tai Chi (TC) is a low-impact exercise shown to enhance sensory function and balance in healthy older adults, but its effects on PN patients remain unclear. Brisk walking (BW) is a widely recommended exercise for older adults, yet its impact on sensory function in PN is not well-established. This study compares TC and BW interventions on tactile sensation in …


Organized Transnational Smuggling Of Narcotic Drugs And Psychotropic Substances: Means, Effects, And International Control Mechanisms, Youness Nafid Jan 2026

Organized Transnational Smuggling Of Narcotic Drugs And Psychotropic Substances: Means, Effects, And International Control Mechanisms, Youness Nafid

Journal of Police and Legal Sciences

This study highlights, discusses, and analyzes the conditions and elements through which the crimes of drug and psychotropic substance trafficking of an organized and transnational nature are realized. These crimes are committed through multiple, complex, and organized means. We based our analysis on the provisions of the United Nations Convention against Transnational Organized Crime, as it is one of the most significant international agreements that serves as a reference for member states in defining and regulating the concept of organized criminal groups, as well as in defining the concept and cases of transnational organized crime.

We called for the enhancement …


The Effects Of Bone-Remodeling Therapy On Survival, Pain, And Skeletal Related Events In The Setting Of Renal Cell Carcinoma With Bone Metastases: A Multicenter Investigation From A Large Global Health Research Network (Trinetx), Brian H. Im, Kevin K. Zarrabi, Aaron R. Hochberg, Mihir M. Shah, Md, James R. Mark, Joseph K. Izes, Patrick T. Gomella, Costas D. Lallas, Leonard G. Gomella, Adam R. Metwalli Jan 2026

The Effects Of Bone-Remodeling Therapy On Survival, Pain, And Skeletal Related Events In The Setting Of Renal Cell Carcinoma With Bone Metastases: A Multicenter Investigation From A Large Global Health Research Network (Trinetx), Brian H. Im, Kevin K. Zarrabi, Aaron R. Hochberg, Mihir M. Shah, Md, James R. Mark, Joseph K. Izes, Patrick T. Gomella, Costas D. Lallas, Leonard G. Gomella, Adam R. Metwalli

Department of Urology Faculty Papers

INTRODUCTION: Renal cell carcinoma (RCC) is the most common renal malignancy-bone metastases (BM) are indicative of aggressive disease with a poor prognosis. We aim to evaluate the overall mortality of patients with RCC with and without BM, and to elucidate the effects of bone-remodeling therapy on mortality, incidence of skeletal-related events, and opioid usage patterns in patients with BM.

METHODS: A retrospective cohort study was conducted using TriNetX, a large, collaborative network sourced from electronic medical records of over 110 million patients from over 100 healthcare organizations. All adult patients with RCC and RCC with BM were queried.

RESULTS: There …


A088: Best Core Stability Training Program For Lower Limb Dysfunction In Stroke Patients: A Network Meta-Analysis, Kaiqi Zheng, Dan Wang, Guoliang Liang, Chunyun Deng Jan 2026

A088: Best Core Stability Training Program For Lower Limb Dysfunction In Stroke Patients: A Network Meta-Analysis, Kaiqi Zheng, Dan Wang, Guoliang Liang, Chunyun Deng

International Journal of Physical Activity and Health

Stroke is the third leading cause of disability and the second leading cause of death among adults. Lower limb dysfunction caused by stroke significantly impairs patients' quality of life. Numerous studies have demonstrated that core stability training (CST) can effectively improve lower limb function in stroke patients, and combining CST with other rehabilitation approaches may yield better therapeutic outcomes. This study aims to identify the most effective CST-based combined intervention for treating lower limb dysfunction in stroke patients. Method: Randomized controlled trials (RCTs) published up to July 22, 2024, were searched from PubMed, Embase, Cochrane Library, Web of Science, CNKI, …


A090: Development And Efficacy Evaluation Of Virtual Reality (Vr)-Based Personalized Exercise Prescriptions For Perimenopausal Women, Runze Zhu, Zekai Wu Jan 2026

A090: Development And Efficacy Evaluation Of Virtual Reality (Vr)-Based Personalized Exercise Prescriptions For Perimenopausal Women, Runze Zhu, Zekai Wu

International Journal of Physical Activity and Health

Perimenopausal women (aged 45–54) frequently experience climacteric symptoms such as vasomotor disturbances, osteoporosis, and cardiovascular risks due to declining ovarian function and estrogen levels. Approximately 75% of women report varying degrees of discomfort, with 80% exhibiting at least one symptom (e.g., sleep disorders, mood fluctuations). Conventional exercise prescriptions often lack specificity to address individual health disparities and comorbidities (e.g., osteoporosis, metabolic dysfunction). This study aimed to develop a virtual reality (VR)-based personalized exercise prescription system to enhance exercise adherence through immersive experiences and evaluate its efficacy in alleviating perimenopausal physiological and psychological symptoms. A personalized exercise prescription generation system was …


A098: Artificial Intelligence Empowers Exercise And Health For The Elderly: Opportunities, Challenges, And Pathways For Implementation, Yaohong Wang, Ke Wang, Yangguiyi Zhao Jan 2026

A098: Artificial Intelligence Empowers Exercise And Health For The Elderly: Opportunities, Challenges, And Pathways For Implementation, Yaohong Wang, Ke Wang, Yangguiyi Zhao

International Journal of Physical Activity and Health

In the context of accelerated global aging and rapid development of artificial intelligence (AI) technology, AI technology provides a new paradigm for improving sports and health management services in the field of elderly care and quality of life. This study aims to reveal the core value of AI technology, analyze the current practical challenges of AI empowerment, and build multidimensional pathways for implementation to promote the coordinated development of healthy aging and technological innovation. Through literature analysis, case studies, and expert interviews, this study systematically explores the application of AI technology in the field of exercise and health of the …


A096: Artificial Intelligence Empowering Physical Education In Higher Education: Logical Tensions And Practical Pathways, Yangguiyi Zhao, Ke Wang, Yaohong Wang Jan 2026

A096: Artificial Intelligence Empowering Physical Education In Higher Education: Logical Tensions And Practical Pathways, Yangguiyi Zhao, Ke Wang, Yaohong Wang

International Journal of Physical Activity and Health

Driven by the strategies of “education digitalization” and “integration of sports and education”, artificial intelligence (AI) technology is reshaping the core values and practical pathways of physical education in higher education. As AI empowers the construction of university sports systems, it has become a key driving force in addressing the challenges of traditional physical education and responding to educational needs. However, AI-driven educational innovation is not a linear evolution; the interplay of its internal logical tensions and external practical constraints necessitates systematic research and pathway exploration. Method: This study systematically explores the multidimensional tensions and coordinated development pathways of artificial …


A095: Blocking Factors And Precision Strategies Of Digital-Driven Governance: Modernization Of Elderly Sports Public Services, Fangfang Yang Jan 2026

A095: Blocking Factors And Precision Strategies Of Digital-Driven Governance: Modernization Of Elderly Sports Public Services, Fangfang Yang

International Journal of Physical Activity and Health

The application of digital technology in the field of sports public services for the elderly presents numerous problems and difficulties. This paper attempts to explore precision strategies for the governance modernization of sports public services for the elderly, driven by digital technology. Analyzing the blocking factors of governance capacity modernization of sports public services driven by digital technologypractical significance for achieving universal health and the construction of a Healthy China. Literature review, expert interviews, and logical analysis. 1. Blocking Factors of Digital-Driven Governance Modernization of Sports Public Services for the Elderly: 1) Weak awareness of digital governance in elderly sports …


A099: Sports-Medicine Integration Treatment Behaviors In Obese College Students: Current Status, Effectiveness, And Influencing Factors, Yunan Li, Dongyue Wei, Shanping Chen, Zhiwei Hu Jan 2026

A099: Sports-Medicine Integration Treatment Behaviors In Obese College Students: Current Status, Effectiveness, And Influencing Factors, Yunan Li, Dongyue Wei, Shanping Chen, Zhiwei Hu

International Journal of Physical Activity and Health

Obesity among college students has become a critical public health issue, impacting their physical and mental health. Sports-Medicine Integration (SMI), an innovative intervention, shows promise for obesity treatment. This study explores the characteristics, effects, and influencing factors of SMI treatments among students, offering insights to improve health literacy and promote holistic well-being in universities. Method: This study employed the "SMI Cognitive Situation Scale" (Gao Shangshang, 2020), the "Exercise Motivation Scale" (Chen Shanping, 2013), and a self-designed "Obesity Treatment Behavior Scale" to survey 1,225 non-physical education majors from general higher education institutions. Data were analyzed using SPSS 29.0. Descriptive statistics assessed …