Life Sciences Commons^™

The Effects Of Agroecological Farming Systems On Human Health, Olivia Kathryn Mason

All Graduate Theses and Dissertations, Fall 2023 to Present

There is a growing concern that the current farming techniques are producing less-nutrient dense soils and foods impacting human health. To improve the health of soils, people, and the plant, a growing number of farmers are using regenerative, or agroecological, farming practices. Some of these methods include multi-cropping (growing various plants on the same plot of land), ley systems (alternating between crops and livestock), and rotational grazing of livestock. Previous studies have found that regenerative farming systems have various benefits for the lands, crops, and animals, as well as increasing the nutrient density of foods.

The purpose of this study …

Linking Microbial Community Assembly In Flowers With Function Under Diverse Environmental Conditions: A Case Study Involving Erwinia Amylovora, Christopher Skylar Mcdaniel

All Graduate Theses and Dissertations, Fall 2023 to Present

Fire blight, a devastating disease of pome fruit trees caused by the bacterium Erwinia amylovora, can cause millions of dollars in losses for producers each year around the globe. Management approaches that involve use of antibiotics, such as streptomycin, can be effective; although concerns exist over pollinator and crop health when using them regularly. Recently, there have been developments that allow for biological agents such as microbes to curtail fire blight infection. These agents work by competing with Erwinia for resources or space, producing antibacterial compounds, or even killing Erwinia cells on contact. Unfortunately, these agents do not yet …

Specialized Recreation, Spatial Behavior, And Ecological Implications In The Nature Reserve Of Orange County, Ca, Jake Van Deursen

All Graduate Theses and Dissertations, Fall 2023 to Present

A widespread surge in park and protected area (PPA) visitation strikes managers with the imminent challenge of preserving ecological conditions and maintaining accessibility in the open spaces that are a fundamental component to the health and wellness needs of society. In the field of recreation resource management, recreation specialization, the selective channeling of interests and abilities into a specific recreational activity, has contributed to comprehensive understandings of recreation behavior, site preference, management perceptions and conservation support. Contributing to historical understandings of specialization can inform recreation planning on the diversity of uses occurring in urban-proximate PPAs. Survey data providing information on …

Relative Hepatotoxocity, Carcinogenicity, And Toxicogenomics Of Select Dehydropyrrolizidine Alkaloids In Mice, Michael J. Clayton

All Graduate Theses and Dissertations, Fall 2023 to Present

Dehydropyrrolizidine alkaloids are arguably the most important plant derived toxins in terms of impact on human and animal health. Dehydropyrrolizidine alkaloids are a large group of chemically related compounds found in 3% of flowering plants worldwide. Human exposure occurs from ingestion of herbal products including teas supplements or contaminated grain. Animals are exposed through contaminated feed or grazing. There are at least 350 identified toxic PAs, from more than 6,000 plants. The toxins primarily cause liver damage, but some are proven to cause cancer. Indidvidual dehydropyrrolizidine alkaloids vary in their toxic effects. Riddelliine is the only dehydropyrrolizidine alkaloid with extensive …

Restoration Strategies For Wetlands In The Arid West: Seeding And Planting Approaches For Lakeshore Ecosystems, Jes Braun

All Graduate Theses and Dissertations, Fall 2023 to Present

Wetlands are widely recognized for their valuable benefits such as providing habitat, improving water quality, and reducing the impacts of flooding. However, wetlands face threats from development, drought, and invasive species. This is particularly apparent in the arid west, where upstream water use and drought make water scarcer and contribute to dramatically changing water levels. Here, I investigated revegetation techniques for lakeshore wetlands, using Utah Lake as a case study. Although recent management efforts have minimized invasive Phragmites cover, the desired plant communities are not returning as quickly as needed, highlighting the need to research restoration techniques. Through my research, …

Furthering Indaziflam-Based Management Strategies Of Three Invasive Annual Grasses In Northern Utah, Peter Weston Maughan

All Graduate Theses and Dissertations, Fall 2023 to Present

Indaziflam is an herbicide highly recognized for its potential to effectively control weedy, winter germinating grasses, such as downy brome, as the herbicides prevents seed germination for several years. Unfortunately, most of these studies only capture the first 2-3 years of indaziflam’s 3-5 years soil activity. This thesis sought to better understand indaziflam’s long-term effects by monitoring both a healthy ecosystem and a degraded ecosystem for up to 5 years after indaziflam application. A secondary study was also conducted to better understand the potential of revegetation via reseeding in indaziflam treated soils. The study concluded that indaziflam very little long-term …

Phenology Of The Invasive Balsam Woolly Adelgid, Adelges Piceae (Ratz.) (Hemiptera: Adelgidae), On Subalpine Fir In Northern Utah, Elizabeth L. Rideout

All Graduate Theses and Dissertations, Fall 2023 to Present

Balsam woolly adelgid (BWA) is an invasive true fir pest in North America. Native to Europe, BWA was first discovered in Utah attacking subalpine fir in 2017. Recent BWA-caused subalpine fir mortality in northern Utah has prompted the need for baseline biological research to support pest management. Small-bodied and blending easily with its environment, BWA is a challenging pest to detect and study. Phenology, or the timing and characteristics of life stages through the year, of BWA varies depending on elevation and climate and is unstudied in Utah. This research focuses on defining aspects of BWA’s phenology, including the number …

The Interplay Between Lung Adenocarcinoma, Nutrient Availability, And The Microbiome., Alexis A. Vega

Electronic Theses and Dissertations

Lung cancer is one of the most common forms of cancer diagnosed, and has the highest lethality rate across all other forms of cancer in the U.S. While current therapeutic options include chemo-, immuno-, and radio-therapy, the benefits of caloric or nutrient restriction on cancer cells has also been investigated. Due to the many biological functions associated with methionine, many have proposed a methionine restricted diet would lead to favorable outcomes when combating cancer. Although our cells are incapable of synthesizing methionine, the bacteria found in our microbiome can. Furthermore, recent discoveries suggest an independent microbiome found within tumors that …

Computational Molecular Docking Studies Of Small Molecule Inhibitors With The Sars-Cov-2 Spike Protein Variants: In-Silico Drug Discovery Using Virtual Screening And Drug Repurposing Approaches, Grace Gupta

Computational and Data Sciences (MS) Theses

The pandemic caused by the emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019 has caused a global public health crisis of nearly unprecedented scale. In the years following the outbreak, the scientific community has mobilized to develop several vaccines and treatments. Drug repurposing as a strategy for drug development has produced many of the current therapeutic options. The greatest challenge to designing a therapeutic inhibitor of SARS-CoV-2 is the shifting mutational landscape of the virus as it evolves. In this study, we focus on the spike protein as a target for potential inhibitors. We explore two …

Effect Of Macrophage Expressed Α7 Nicotinic Acetylcholine Receptor (Α7nachr) On Migration Of Macrophages During Inflammation, Kasey Keever

Electronic Theses and Dissertations

Sepsis is a life-threatening condition characterized by overwhelming inflammation, resulting in organ system damage, leading to a high mortality rate. Care in the clinical setting is supportive, and there are no approved sepsis-specific treatments. In septic mice, activation of the cholinergic anti-inflammatory pathway decreases cytokine secretion by leukocytes and improves survival. The cholinergic anti-inflammatory pathway is a reflex of the parasympathetic nervous system, converging on the α7 nicotinic acetylcholine (α7nAChR) at the surface of macrophages. Signaling through the receptor blocks NF-kB activation, thus cytokine secretion. Receptor activation has other effects on macrophages, including modulating their migration to …

The Impact Of Environmental Pollutants On Alcohol-Associated Liver Disease Pathogenesis., Tyler Charles Gripshover

Electronic Theses and Dissertations

Steatotic liver disease is brought upon by differing etiologies and its global prevalence is expected to keep increasing over the next several decades. Particularly, alcohol-associated liver disease (ALD) manifests from excessive alcohol consumption where the liver retains lipids and progresses with metabolic dysfunction. Previous studies have demonstrated that environmental pollutants, polychlorinated biphenyls (PCBs) promote metabolic dysfunction associated steatotic liver disease (MASLD), in diet-induced obesity models. However, it is unknown if environmental pollutants may also promote ALD pathogenesis. Thus, this dissertation focuses on characterizing the effects of PCB126 in a rodent ALD model followed by multiple ‘Omics approaches to identify mechanisms …

Biocargos: Capture And Release Gels For Optimized Storage Of Biologics., Chinmay Shashank Potnis

Electronic Theses and Dissertations

No abstract provided.

Using A Toxic Aging Coin To Assess Hexavalent Chromium-Induced Neurotoxicity., Samuel Thomas Vielee

Electronic Theses and Dissertations

We are facing an aging crisis, with 20% of the U.S. population projected to be geriatric (65+) by 2030 and live another 40+ years. Age-related diseases accompany a growing geriatric population, emphasizing the need to understand their etiology. Environmental pollutants compound this crisis by: 1) geriatrics are more susceptible, exacerbating age-related diseases and comorbidities, and 2) they accelerate biological aging, inducing age-related diseases at younger ages. We address this crisis using a ‘toxic aging coin’ approach; heads examines how age impacts toxicity, tails examines how chemicals accelerate aging. This thesis applies the heads side for Cr(VI)-induced neurotoxicity across ages. We …

Effects Of A Protection Zone In A Reaction-Diffusion Model With Strong Allee Effect., Isaac Johnson

Electronic Theses and Dissertations

A protection zone model represents a patchy environment with positive growth over the protection zone and strong Allee effect growth outside the protection zone. Generally, these models are considered through the corresponding eigenvalue problem, but that has certain limitations. In this thesis, a general protection zone model is considered. This model makes no assumption on the direction of the traveling wave solution over the Strong Allee effect patch. We use phase portrait analysis of this protection zone model to draw conclusions about the existence of equilibrium solutions. We establish the existence of three types of equilibrium solutions and the necessary …

Breaking Virulent: The Coincidental Evolution Of Virulence Factors In Bacteria., Rhiannon Emmanuelle Cecil

Electronic Theses and Dissertations

Understanding how innocuous organisms can evolve to be pathogenic to humans is of increasing global concern. Further, understanding how existing pathogens may evolved to be more virulent is also vital to our ability to provide healthcare to people afflicted with diseases that promote chronic bacterial infections, such as cystic fibrosis. With the rise of antibiotic resistance in both bacteria and fungi it is paramount that new therapeutics are identified. Understanding what mutations occur that result in increased virulence in microbes can potentially provide new targets for antimicrobial drugs to combat antibiotic resistance. The Coincidental Evolution Hypothesis is a fundamental hypothesis …

The Distribution And Reproductive Success Of The Western Snowy Plover Along The Central And Southern Oregon Coast - 2023, David J. Lauten, Kathleen A. Castelein, Mary Lee, Jacey Corrente, Marty R. Mccamant, Eleanor P. Gaines

Institute for Natural Resources Publications

We monitored the distribution, abundance and productivity of the federally threatened Western Snowy Plover (Anarhynchus nivosus nivosus) along the central and south coast of Oregon from 4 April – 15 September 2023. We surveyed and monitored plover activity in a project area that included, from north to south, Sutton Beach, Siltcoos River estuary, the Dunes Overlook, North Tahkenitch Creek, Tenmile Creek, Coos Bay North Spit, Bandon Snowy Plover Management Area, New River Habitat Restoration Area (HRA) and adjacent lands, and Floras Lake. Our objectives for the project area in 2023 were to: 1) estimate the size of the adult Snowy …

Identification And Delineation Of Neuronal Pathways Underlying Hypophagia, Jing Cai

Dissertations & Theses (Open Access)

In terms of metabolism, eating disorders manifest in two extreme directions: overnutrition, which can lead to obesity, and malnutrition, which can result in underweight or even starvation. Both extremes compromise the quality of life. According to the Diagnostic and Statistical Manual of Mental Disorders-5 (DSM-5) standard, eating disorders affect up to 17.9% of young women and 2.4% of young men. Although eating disorders are primarily defined as mental disorders rather than metabolic disorders, they are intertwined with complex emotions and sensory perceptions. However, in contemporary animal research related to eating disorders and feeding behaviors, the majority of neuroscientists still examine …

Effects Of Dietary Rumen-Protected Choline Supplementation To Periparturient Dairy Cattle On Inflammation, Metabolism, And Performance During An Intramammary Lipopolysaccharide Challenge, Turner H. Swartz, Barry Bradford, Laman Mamedova, Kari Estes

Dairy Science and Food Science Faculty Publications: 2022 to Present

Recent studies have suggested that dietary rumen-protected choline (RPC) supplementation can modulate immune function, attenuate inflammation, and improve performance in periparturient dairy cattle; however, this has yet to be evaluated during a mastitis challenge. Therefore, the objective of this study was to examine the effects of supplementation and dose of RPC on metabolism, inflammation, and performance during an intramammary lipopolysaccharide (LPS) challenge. Parous Holstein cows (parity, mean ± SD, 1.9 ± 1.1 at enrollment) were blocked by calving month and randomly assigned within block to receive either 45 g/d of RPC (20.4 g/d of choline ions; CHOL45, n = 18), …

Aicropcam: Deploying Classification, Segmentation, Detection, And Counting Deep-Learning Models For Crop Monitoring On The Edge, Nipuna Chamara, Geng (Frank) Bai, Yufeng Ge

Biological Systems Engineering: Papers and Publications

Precision Agriculture (PA) promises to meet the future demands for food, feed, fiber, and fuel while keeping their production sustainable and environmentally friendly. PA relies heavily on sensing technologies to inform site-specific decision supports for planting, irrigation, fertilization, spraying, and harvesting. Traditional point-based sensors enjoy small data sizes but are limited in their capacity to measure plant and canopy parameters. On the other hand, imaging sensors can be powerful in measuring a wide range of these parameters, especially when coupled with Artificial Intelligence. The challenge, however, is the lack of computing, electric power, and connectivity infrastructure in agricultural fields, preventing …

Species Richness Of Moths In Parks Surrounded By Varying Levels Of ​Urbanization Around Nashville, Tennessee, Maxwell Stone, Allie Bennett

Science University Research Symposium (SURS)

Moths can act as indicators of environmental wellness due to their pollution sensitivity and the complexity of biodiversity required to support their life cycles. Urbanization can impact the occurrence of moths in protected green spaces. Higher moth species richness was hypothesized to occur in parks surrounded by more rural areas. Three metropolitan parks were chosen in the Nashville area: downtown, within a suburban neighborhood, and in a rural area. Tree canopy cover and degree of impervious surfaces were assessed for each park and surrounding area using iTreeCanopy. Moths were attracted to a white sheet using a mercury vapor bulb, UV …

Assessment Of Green Spaces In Metro Nashville Public High Schools, Webster G. Andrews, Anna Lennon, Darlene Panvini

Science University Research Symposium (SURS)

Green spaces on and near school property have been correlated to student mental health and academic achievement. However, there is a gap in the literature investigating how quality and quantity of green space is related to socioeconomic status and school economic metrics in public high schools and the surrounding neighborhoods. Nashville public high schools located in higher socioeconomic areas and having greater financial resources were predicted to provide larger, higher quality green spaces. This study combined a quantitative analysis of neighborhood socioeconomic metrics, school socioeconomic metrics, and quantity of green space (assessed using iTree Canopy) with a qualitative field assessment …

Yellowtail Snapper Ocyurus Chrysurus, Kevin Rafferty, Manuel Ploner, David W. Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

YELLOWTAIL SNAPPER OCYURUS CHRYSURUS 7.5CM Total length

Lionfish (Pterois Volitans) Neurocranium, Kate Heffner, Hosanna Gattle, David Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

Neurocranium from 30 cm total length (TL) Lionfish (Pterois volitans), collected from Second Reef on 15/10/2023 by Kate Heffner.

Development And Validation Of Molnupiravir Assessment In Bulk Powder And Pharmaceutical Formulation By The Rp-Hplc-Uv Method, Ekram Hany Mohamed, A. H. Abdel Aziz, Noha M. El Zahar,, Nour El-Din A. Abdel-Sattar, Safwat A. Mahmoud,, Mohamed S. Attia,

Pharmacy

An accurate, sensitive and selective RP-HPLC-UV method has been established for the estimation of Molnupiravir (MOL) in pure bulk powder and pharmaceutical formulation. Separation was achieved on an Inertsil C18 column (150.0 mm × 4.6 mm, 5.0 μm), using a mobile phase of 20 mM phosphate buffer pH 2.5 : acetonitrile (80 : 20, v/v%) in isocratic mode with a flow rate of 1.0 mL min−1. The λmax of MOL prepared in the chosen diluent (ethanol : water in equal proportions) was found to be 230.0 nm. The constructed calibration curve was found to be linear in the concentration range …

Trehalose Enhances Mitochondria Deficits In Human Npc1 Mutant Fibroblasts But Disrupts Mouse Purkinje Cell Dendritic Growth Ex Vivo., Collin M Macleod, Fawad A K Yousufzai, Liam T Spencer, Sarah Kim, Lucianne A Rivera-Rosario, Zerian D Barrera, Lindsay Walsh, Claude Krummenacher, Benjamin Carone, Ileana Soto

Faculty Scholarship for the College of Science & Mathematics

Lysosomes play important roles in catabolism, nutrient sensing, metabolic signaling, and homeostasis. NPC1 deficiency disrupts lysosomal function by inducing cholesterol accumulation that leads to early neurodegeneration in Niemann-Pick type C (NPC) disease. Mitochondria pathology and deficits in NPC1 deficient cells are associated with impaired lysosomal proteolysis and metabolic signaling. It is thought that activation of the transcription factor TFEB, an inducer of lysosome biogenesis, restores lysosomal-autophagy activity in lysosomal storage disorders. Here, we investigated the effect of trehalose, a TFEB activator, in the mitochondria pathology of NPC1 mutant fibroblasts in vitro and in mouse developmental Purkinje cells ex vivo. We …

Editorial: The Public Health Scholars As The Health Leaders, Al Asyary, Meita Veruswati, Putri Bungsu Machmud, Indri Hapsari Susilowati

Kesmas

No abstract provided.

Data From: Climate Change-Driven Cumulative Mountain Pine Beetle-Caused Whitebark Pine Mortality In The Greater Yellowstone Ecosystem, William W. Macfarlane

Browse all Datasets

In 2018-2019 the Landscape Assessment System (LAS), an aerial survey method was used to assess mountain pine beetle (Dendroctonus ponderosae; MPB) - caused mortality of whitebark pine (Pinus albicaulis) across the Greater Yellowstone Ecosystem (59000 km2; GYE). This consisted of 11,942 km of flightlines, along which 4,434 geo-tagged, oblique aerial photos were captured and processed. A mortality rating of none to severe (0 to 4 nt attack or 5.0 5.4 old attack) was assigned to each photo based on the amount of red (recent attack) and gray (old attack) trees visible. The method produced a photo inventory of 74 percent …

Standardized Total Fitness Scores And Phase Angle In Cancer Survivors, Paulette Yamada, Trevor Short

Topics in Exercise Science and Kinesiology

Topics in Exercise Science and Kinesiology Volume 4: Issue 1, Article 20, 2023. Cancer treatment can lead to decrement in all components of fitness. Exercise can attenuate these effects and build fitness. Exercise program design for this population continues to evolve with high-intensity interval training at the forefront. Phase angle (PhA) is an indirect measure of cellular health and function and is associated with fitness, health, and reduced disease severity. Continued exploration spurs an emerging question: What type of training should be used to maximize improvements in PhA? We provide a visualization of a cancer rehabilitation fitness profile and present …

Adding Context To Monitoring Neuromuscular Status In High-Performance Sport, Trevor Short, Trevor Sackmann, Paulette Yamada

Topics in Exercise Science and Kinesiology

Topics in Exercise Science and Kinesiology Volume 4: Issue 1, Article 19, 2023. Utilizing performance tests alone without the contextualization of other information may mislead practitioners in the decision-making process. Thus, the purpose of this Topic Brief is to provide practitioners a decision tree and systematic triangulation approach for adding context to assessing neuromuscular status, which provides a clear picture of how to prepare an athlete for competition.

Monitoring Readiness Using The Hooper Index In American Football Players: Defining Flagging Thresholds, Trevor Short, Kody Cooke, Paulette Yamada

Topics in Exercise Science and Kinesiology

Topics in Exercise Science and Kinesiology Volume 4: Issue 1, Article 18, 2023. The purpose of this article is to illustrate how the Hooper Index, which to our knowledge has not been utilized in American Football, can notify the practitioner when to modify training or apply recovery interventions throughout the season.