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Full-Text Articles in Life Sciences

Evolution And Selection: From Suppression Of Metabolic Deficiencies To Bacteriophage Host Range And Resistance, Daniel Kurt Arens Apr 2021

Evolution And Selection: From Suppression Of Metabolic Deficiencies To Bacteriophage Host Range And Resistance, Daniel Kurt Arens

Theses and Dissertations

The evolution and adaptation of microorganisms is so rapid it can be seen in the time frame of days. The root cause for their evolution comes from selective environmental pressures that see organisms with beneficial mutations survive otherwise deadly encounters or outperform members of its population who fail to adapt. This does not always result in strict improvement of the individual as in the case of antibiotic resistant bacteria who often display fitness tradeoffs to avoid death (see Reviews [1-3]). For example, when an ampicillin resistance gene (ampC) containing plasmid that is occasionally found in the wild was transformed into ...


Test-Enhanced Learning In Post-Secondary Biology Courses: The Effect Of Cues And Incentives On High-Level Learning, Bryn Ellen St. Clair Apr 2021

Test-Enhanced Learning In Post-Secondary Biology Courses: The Effect Of Cues And Incentives On High-Level Learning, Bryn Ellen St. Clair

Theses and Dissertations

Cognitive scientists and psychology researchers have given growing attention to evidence of the testing effect, that is, the improvement of students' recall through memory-retrieval practice in the form of quizzes and exams. While laboratory experiments consistently show dramatic positive effects on learning through the testing effect, discipline-specific education researchers have sought to generalize these findings in real, instead of simulated classrooms. The objective of this dissertation was threefold: (1) To survey the current literature on the testing-effect as it applies to learning biology at the post-secondary level. In this review, I consider how further research on the testing effect may ...


Using Geospatial Tools To Assess Changes To Marine Ecosystems In Small Island Developing States Following Hurricane Disturbances: A Case Study Of Dominica After Hurricane Maria, Ryan J. Shields Apr 2021

Using Geospatial Tools To Assess Changes To Marine Ecosystems In Small Island Developing States Following Hurricane Disturbances: A Case Study Of Dominica After Hurricane Maria, Ryan J. Shields

Theses and Dissertations

Seagrass meadows, like coral reefs, are in decline globally but are often neglected in marine policy and conservation despite their equally critical ecosystem services. Both habitats can be heavily impacted by wave surges, rainfall-induced earth movement and flooding, changes to water temperature, salinity, and acidity, and increased levels of turbidity—all occurring at increased rates due to a changing global climate. We demonstrate that multispectral satellite imagery, geospatial tools, and classification techniques can be used to inform management by identifying and quantifying changes in seagrass distribution and the presence of sediment-related threats. Results from Dominica indicate near-shore seagrass habitat area ...


Use Of Flash Flaming Technology To Improve Seed Handling And Delivery Of Winterfat (Krascheninnikovia Lanata), Mitchell Grant Thacker Mar 2021

Use Of Flash Flaming Technology To Improve Seed Handling And Delivery Of Winterfat (Krascheninnikovia Lanata), Mitchell Grant Thacker

Theses and Dissertations

Ecological restoration of rangelands using wild-collected seeds can be challenging due to low seed quality, inconvenient seed anatomy, and poor plant establishment. In North America, the half-shrub winterfat (Krascheninnikovia lanata) is a valuable protein-rich forage for wildlife and livestock. Seeds of this species are contained in one-seeded fruits enclosed in four fluffy, silky bracts. While the seeds can be removed from the bracts, it is not recommended as the bracts are thought to help protect the seed and aid in germination and seedling growth. However, bracts of winterfat make it difficult to incorporate this species within a seed mix because ...


Weekly One-Day Water-Only Fasting Interventional Trial For Low-Density Lipoprotein Cholesterol Reduction (Wonderful), Ciera Lynn Bartholomew Mar 2021

Weekly One-Day Water-Only Fasting Interventional Trial For Low-Density Lipoprotein Cholesterol Reduction (Wonderful), Ciera Lynn Bartholomew

Theses and Dissertations

Purpose: Fasting has been promoted as a method of preventing disease and aging for thousands of years. With heart disease being a leading cause of death in the U.S., researchers have explored the effects of fasting on variables that influence cardiovascular disease (CVD), like LDL cholesterol. Therefore, the purpose of this study was to assess the effects of weekly water-only fasting on LDL cholesterol (LDL-C) in men and women with metabolic risk factors for CVD. Methods: This study was a randomized control trial in adult men and women. Participants were randomized to fasting (treatment) or normal diet (control). The ...


Improving Perennial Bunchgrass Seeding Success In Annual Grass Invaded Areas Using Pre-Emergent Herbicide And Furrowing Techniques, Spencer Chad Camp Mar 2021

Improving Perennial Bunchgrass Seeding Success In Annual Grass Invaded Areas Using Pre-Emergent Herbicide And Furrowing Techniques, Spencer Chad Camp

Theses and Dissertations

Exotic annual weeds have transformed western North America, particularly in sagebrush-steppe systems. Restoration of these invaded sites has been met with low levels of success. Pre-emergent herbicide provides a means to control annual weeds, but typically, this treatment does not allow for the concurrent seeding of desired species. Seeding within a deep, U-shaped furrow following herbicide application may be a method to reduce pre-emergent herbicide effects by transferring the herbicide away from the seed at the time of planting. We tested this potential planting technique by spraying plots with or without the pre-emergent herbicide imazapic, and planting bunchgrass seeds either ...


The Relationship Between Hip Mobility And Performance On The Functional Movement Screen In Apparently Healthy Older Adults: A Preliminary Study, Kimberly Jaye Lindstrom Mar 2021

The Relationship Between Hip Mobility And Performance On The Functional Movement Screen In Apparently Healthy Older Adults: A Preliminary Study, Kimberly Jaye Lindstrom

Theses and Dissertations

Limited or asymmetrical hip mobility can affect movement patterns common to everyday living. The aim of this study was to evaluate the relationship between hip mobility and performance on the Functional Movement Screen (FMS) in apparently healthy older adults. This relationship was evaluated in both males and females. In this observational study, 20 older adults (10 male, 10 female, mean age = 65.65 ± 10.18 years old) completed the Functional Movement Screen and measurements of passive hip range of motion. Separate regression analyses and Pearson Product-Moment Correlations were used to evaluate the relationship between hip mobility measures and FMS composite ...


Supplemental Material (Metabolomics Of Acid Whey Derived From Greek Yogurt), Muriel Allen Feb 2021

Supplemental Material (Metabolomics Of Acid Whey Derived From Greek Yogurt), Muriel Allen

ScholarsArchive Data

Supplemental material from the study Metabolomics of Acid Whey Derived from Greek Yogurt.


Cystic Fibrosis: An Ecological Review, Christopher Bozer Jan 2021

Cystic Fibrosis: An Ecological Review, Christopher Bozer

Student Works

This article focuses on the mechanisms of cystic fibrosis and the resulting microbial dysbiosis created through this disease. Through mutations in the CFTR gene, chloride ion proteins become dysfunctional, and mucus secreted in the lungs become thick and heavy, allowing infectious and pathogenic bacteria to thrive. 16s rRNA has been the primary method of sequencing the lung microbiome. Researchers have relied on bronchoscopies to collect proper samples. It can be concluded through current research that chloride ion dysfunction allows for an abnormal lung environment to develop. This abnormal environment allows for chronic infection of the lungs, and the formation of ...


Testing The Effect Of Aquarium-Based Learning On Patron Acceptance Of Evolutionary Theory, Jamie Jensen, Ethan R. Tolman, Spencer G. Shumway, Liam S. Williams Jan 2021

Testing The Effect Of Aquarium-Based Learning On Patron Acceptance Of Evolutionary Theory, Jamie Jensen, Ethan R. Tolman, Spencer G. Shumway, Liam S. Williams

ScholarsArchive Data

This is data collected prior to and directly following an intervention at a public aquarium in Idaho surrounding the reconciliation of evolution with religious audiences.


Antimicrobial Peptide Development: From Massively Parallel Peptide Sequencing To Bioinformatic Motif Identification, Alexander K. Erikson Dec 2020

Antimicrobial Peptide Development: From Massively Parallel Peptide Sequencing To Bioinformatic Motif Identification, Alexander K. Erikson

Theses and Dissertations

The isolation, purification, and clinical deployment of antibiotics is one of the major drivers of decrease in morbidity and mortality from infectious bacteria in the 20th century. The rapid, ubiquitous deployment of antibiotics encouraged swift development and distribution of antibiotic resistance. New, novel techniques, technologies, and ultimately therapeutic antimicrobial compounds will be required to counter the rise of antibiotic resistant microbes. Historically, mimicking naturally occurring compounds has been the most fruitful method for discovering new antibiotics; unsurprisingly, many recent efforts have focused on expanding the cultivation and detection of previously unknown microbes and compounds, respectively. Other techniques explore developing compounds ...


Using Structural Equation Modeling To Model Compliance With Covid-19 Related Non-Pharmaceutical Interventions Amongst University Students In The United States, Spencer G. Shumway, Jonas D. Hopper, Ethan R. Tolman, Daniel G. Ferguson, Gabriella Hubble, David Patterson, Jamie Jensen Dec 2020

Using Structural Equation Modeling To Model Compliance With Covid-19 Related Non-Pharmaceutical Interventions Amongst University Students In The United States, Spencer G. Shumway, Jonas D. Hopper, Ethan R. Tolman, Daniel G. Ferguson, Gabriella Hubble, David Patterson, Jamie Jensen

ScholarsArchive Data

There are two data files. The "General Data" comes from a nationwide poll using Qualtrics polling software. The "Utah Data" comes from undergraduate biology students at UVU and BYU. The survey gathered demographic data and attitudes toward the COVID pandemic.


A Lake Divided: Regional Shifts In Trophic Niche Structure Of Lake Powell Fishes Corresponding To The Invasion Of Quagga Mussels, Nathan Richard St Andre Dec 2020

A Lake Divided: Regional Shifts In Trophic Niche Structure Of Lake Powell Fishes Corresponding To The Invasion Of Quagga Mussels, Nathan Richard St Andre

Theses and Dissertations

Introduced species can become invasive and cause catastrophic alterations to the system they invade. Both zebra mussels (Dreissena polymorpha) and quagga mussels (Dreissena bugensis) have caused significant ecosystem alterations wherever they have invaded. These Dreissena species have caused changes in water quality and biodiversity and have disrupted energy pathways which can have cascading effects on other trophic levels. Recently quagga mussels invaded Lake Powell, a reservoir located in the southwestern USA, creating the possibility of a trophic cascade that could alter energy flow in the reservoir and change the trophic niche structure of the fishes in the lake. However, due ...


Hydroxychloroquine Prophylaxis For Covid-19, David D. Busath Oct 2020

Hydroxychloroquine Prophylaxis For Covid-19, David D. Busath

Faculty Publications

It is common in medicine that simple, inexpensive remedies are held hostage to medical prejudice, financial or political interest, and legal precedent. The purpose of this review is to take the point of view of the victims of COVID-19 and address whether scientific information, including randomized-control trials, can answer whether the hydroxychloroquine should be dispensed for those testing positive and their immediate recent contacts at the point of testing. Although the FDA in the United States is yet to be convinced, the demonstration of positive effects in clinical trials cannot be ignored and there is a large amount of information ...


Governing Dynamics Of Divalent Copper Binding By Influenza A Matrix Protein 2 His37 Imidazole, Kelly Lewis Mcguire Aug 2020

Governing Dynamics Of Divalent Copper Binding By Influenza A Matrix Protein 2 His37 Imidazole, Kelly Lewis Mcguire

Theses and Dissertations

Influenza A is involved in hundreds of thousands of deaths globally every year resulting from viral infection-related complications. Previous efforts to subdue the virus by preventing proper function of wild-type (WT) neuraminidase (N), and M2 proteins using oseltamivir and amantadine (AMT) or rimantadine (RMT), respectively, exhibited success initially. Over time, these drugs began exhibiting mixed success as the virus developed drug resistance. M2 is a proton channel responsible for the acidification of the viral interior which facilitates release of the viral RNA into the host. M2 has a His37-tetrad that is the selective filter for protons. This protein has been ...


Predation Environment Does Not Predict Life History In Morphologically-Constrained Fish Alfaro Cultratus (Cyprinodontiformes: Poeciliidae), Kaitlyn Beard Golden Jul 2020

Predation Environment Does Not Predict Life History In Morphologically-Constrained Fish Alfaro Cultratus (Cyprinodontiformes: Poeciliidae), Kaitlyn Beard Golden

Theses and Dissertations

Predation is known to have a significant effect on life history, eliciting predictable responses. Physical constraints of body shape and size may also limit life history divergence. There may be a trade-off between adapting to predation, and limits placed by constraints that decrease life history divergence. We test this idea in the Costa Rican livebearing fish Alfaro cultratus. This species has a keeled ventral surface and does not develop a distended abdomen when pregnant like other livebearers. We describe the life history of A. cultratus in 20 different populations across predator and non-predator environments. We found significantly lower reproductive allotment ...


The Effects Of Exercise On The Fasting Ketone Production Curve: A Randomized Crossover Study, Landon S. Deru Jul 2020

The Effects Of Exercise On The Fasting Ketone Production Curve: A Randomized Crossover Study, Landon S. Deru

Theses and Dissertations

Elevated ketone production and utilization results in a host of health benefits. The aim of this study was to assess the rate of ketone production during a prolonged fast and to evaluate how an initial bout of exercise influences this production. Mood and hunger, along with plasma insulin and glucagon, were also assessed. In this crossover study, 20 adult subjects (11 Male, 9 Female) completed two 36-hour fasts, with one protocol requiring the subject to complete an intense treadmill exercise session at the beginning of the fast. Ketone levels were assessed via blood ketone meter and recorded every two hours ...


Short-Term Effects Of Increased Body Mass And Distribution On Plantar Shear, Postural Control, And Gait Kinetics: Implications For Obesity, Hwigeum Jeong Jul 2020

Short-Term Effects Of Increased Body Mass And Distribution On Plantar Shear, Postural Control, And Gait Kinetics: Implications For Obesity, Hwigeum Jeong

Theses and Dissertations

Context: Obesity is a growing global health concern. The increased body mass and altered mass distribution associated with obesity may be related to increases in plantar shear that putatively leads to physical functional deficits. Therefore, measurement of plantar shear may provide unique insights on the effects of body mass and body distribution on physical function or performance. Purpose: 1) To investigate the effects of body mass and distribution on plantar shear; 2) To examine how altered plantar shear influences postural control and gait kinetics. Hypothesis: 1) a weighted vest forward distributed (FV) would shift the center of pressure (CoP) location ...


Saving Our Backs: Reducing Low Back Forces, Investigating Pain, And Observing Multifidus, Robert Eugene Larson Jul 2020

Saving Our Backs: Reducing Low Back Forces, Investigating Pain, And Observing Multifidus, Robert Eugene Larson

Theses and Dissertations

BACKGROUND: Healthcare workers are among the most injured workers in the United States. This is due to the high rate of patient handling. The low back is the most injured in this population. This study observed biomechanical factors and how these factors affect low back and ground reaction forces. This study further investigated pain and its relationship to low back force, multifidus cross-sectional area, and multifidus activation in healthcare workers. METHODS: The 45 participants included 10 healthy subjects in the preliminary study and 35 active healthcare workers in the main study. Subjects filled out the VAS to determine current pain ...


Pedagogical Approaches And Instructional Content That Predict Increased Acceptance Of Biological Evolution In University Students, Clinton Thomas Laidlaw Jun 2020

Pedagogical Approaches And Instructional Content That Predict Increased Acceptance Of Biological Evolution In University Students, Clinton Thomas Laidlaw

Theses and Dissertations

Evolution is the central organizing theory of biology. Without evolutionary theory, biology becomes a somewhat tangential assemblage of facts about living organisms, which is precisely how it is viewed by many students. Many teachers teach evolution in a limited capacity or avoid it entirely due to fear of opposition, lack of confidence in their own understanding, or lack of acceptance of the theory themselves. When evolution is not taught, or is not accepted, it cannot be utilized to make sense of the field, and is quickly forgotten by students. While some studies have shown a correlation between instruction about evolution ...


Cronobacter Sakazakii Genes Contributing To Persistencein Low-Moisture Dairy Matrices, Kaitlin Ash Hartmann Jun 2020

Cronobacter Sakazakii Genes Contributing To Persistencein Low-Moisture Dairy Matrices, Kaitlin Ash Hartmann

Theses and Dissertations

Cronobacter sakazakii is a gram-negative opportunistic pathogen known to survive in dry environments and food matrices, such as infant formula. This foodborne bacterium can cause fatal human infections of the blood, central nervous system, and gastrointestinal tract; it is also problematic in wounds and urinary tract infections. Preterm infants and immunocompromised individuals are in higher risk categories related to necrotizing enterocolitis, neonatal sepsis, and meningitis due to this organism. Therefore, there is a need for increased understanding of how this bacterium is able to persist in thermally treated low-moisture products that do not support growth. The objective of this research ...


Isothermal Inactivation Of Salmonella, Listeria Monocytogenes, And Enterococcus Faecium Nrrl-B 2354 In Peanut Butter, Powder Infant Formula, And Wheat Flour, Adam Robert Quinn Jun 2020

Isothermal Inactivation Of Salmonella, Listeria Monocytogenes, And Enterococcus Faecium Nrrl-B 2354 In Peanut Butter, Powder Infant Formula, And Wheat Flour, Adam Robert Quinn

Theses and Dissertations

Pathogens in low-moisture foods are an emerging food safety concern due to increased survival and thermotolerance in matrices with low water activity. However, limited data is publicly available for the thermotolerance of Listeria monocytogenes, Salmonella spp., and Enterococcus faecium NRRL B-2354 (a Salmonella surrogate). The aims of this study were to identify differences in thermal inactivation rates between these organisms in three different low-moisture foods. Three model low-moisture foods (peanut butter, powder infant formula, and wheat flour) were inoculated with either E. faecium, a Salmonella spp. cocktail, or a L. monocytogenes cocktail using a dry inoculation method for a total ...


A System For Foot Joint Kinetics – Integrating Plantar Pressure/Shear With Multisegment Foot Modeling, Spencer Ray Petersen Jun 2020

A System For Foot Joint Kinetics – Integrating Plantar Pressure/Shear With Multisegment Foot Modeling, Spencer Ray Petersen

Theses and Dissertations

Introduction: Instrumented gait analysis and inverse dynamics are commonly used in research and clinical practice to calculate lower extremity joint kinetics, such as power and work. However, multisegment foot (MSF) model kinetics have been limited by ground reaction force (GRF) measurements. New technology enables simultaneous capture of plantar pressure and shear stress distributions but has not yet been used with motion capture. Integrating MSF models and pressure/shear measurements will enhance the analysis of foot joint kinetics. The purpose of this study was to develop methodology to integrate these systems, then analyze the effects of speed on foot joint kinetics ...


Sclerocactus Wrightiae (Cactaceace): An Evaluation Of The Impacts Associated With Cattle Grazing And The Use Of Remote Sensing To Assess Cactus Detectability, Thomas Hathaway Bates Apr 2020

Sclerocactus Wrightiae (Cactaceace): An Evaluation Of The Impacts Associated With Cattle Grazing And The Use Of Remote Sensing To Assess Cactus Detectability, Thomas Hathaway Bates

Theses and Dissertations

The Wright fishhook cactus (Sclerocactus wrightiae L.D. Benson) is an endangered cactus species endemic to south-central Utah. Since its listing in 1979 by the U.S. Fish and Wildife Service, the potential impacts of soil disturbance by cattle have become a central focus of management policies and monitoring efforts. However, little to no empirical data has been collected to substantiate the hypothesis that soil disturbance by cattle has direct or indirect negative effects on Wright fishhook cactus growth or reproduction. Over the years, the Bureau of Land Mangement (BLM) and Capitol Reef National Park (CRNP) have invested significant resources ...


Effect Of Water Consumption On Resting Metabolism In Adults, Brittany Leigh Murphy Apr 2020

Effect Of Water Consumption On Resting Metabolism In Adults, Brittany Leigh Murphy

Theses and Dissertations

This study analyzed the acute effect of water consumption on resting metabolic rate (RMR). It was hypothesized that water would have a small, nonclinically significant effect on RMR. Men and women ages 18–40 years participated in a crossover study in which each participant received a No Water and Water condition (order determined randomly) with a 7-day washout period between each condition. Both conditions began with visual analog scales to gauge hunger and thirst levels, urine spectrometry to quantify hydration status, and height and weight measurements. The No Water condition consisted of a 30-minute rest period followed by 45 minutes ...


Characterization Of Hemicellulose Biosynthesis Genes In Avena, Melissa Coon Fogarty Apr 2020

Characterization Of Hemicellulose Biosynthesis Genes In Avena, Melissa Coon Fogarty

Theses and Dissertations

Avena sativa L. (2n = 6x = 42, AACCDD genome composition) or common oat is the cereal grain possessing the highest levels of water-soluble seed (1-3,1-4)-β-D-glucan (β-glucan), a hemicellulose important to human health due to its ability to lower serum LDL cholesterol levels. Understanding the mechanisms of β-glucan accumulation in oat endosperm is, consequently, of great interest. We report a genome-wide association study (GWAS) to identify quantitative trait loci (QTLs) controlling β-glucan production in oat, identifying 58 significantly associated markers. Synteny with the barley (Hordeum vulgare L.) genome identified four major regions of interest, the CslF and CslH gene families ...


A Comparison Of Chikungunya Virus Infection, Dissemination, And Cytokine Induction In Human And Murine Macrophages And Characterization Of Rag2-/-Γc-/- Mice As An Animal Model To Study Neurotropic Chikungunya Disease, Israel Guerrero Apr 2020

A Comparison Of Chikungunya Virus Infection, Dissemination, And Cytokine Induction In Human And Murine Macrophages And Characterization Of Rag2-/-Γc-/- Mice As An Animal Model To Study Neurotropic Chikungunya Disease, Israel Guerrero

Theses and Dissertations

Chikungunya virus (CHIKV) is classified as an alphavirus in the Togaviridae family. This virus is known to rely on Aedes arthropod vectors for its dissemination. Human infection is characterized by rash, high fever, and severe chronic polyarthritis that can last for years. Recently, efforts in developing animal models have been made in an attempt to better understand CHIKV pathogenesis. CHIKV infection starts with a 7 to 10 day long febrile acute phase, in which most of the symptoms occur (rash, fever, and incapacitating pain in joints and muscle). Once the immune system clears most of the viral infection, a chronic ...


Enhanced Efficiency Nitrogen Fertilizer: Coated Urea, Savannah R. Fahning, Bryan G. Hopkins Apr 2020

Enhanced Efficiency Nitrogen Fertilizer: Coated Urea, Savannah R. Fahning, Bryan G. Hopkins

Library/Life Sciences Undergraduate Poster Competition 2020

Nutrient loss contributes to pollution, depletion of natural resources, and economic loss

Enhanced Efficiency Fertilizers (EEF) increase uptake efficiency and crop yield/quality

This research focuses on Nitrogen EEF, namely Coated Urea


Why Parents Say No To Having Their Children Vaccinated Against Measles: A Systematic Review Of The Social Determinants Of Parental Perceptions And Family Approaches To Addressing Mmr Vaccine Hesitancy, M. Lelinneth B. Novilla, Michael C. Goates, Mallory Showalter, L. Kirsten Novilla, Russell Doria, Michael Dang, Katelyn Aldridge, Tyler Leffler Apr 2020

Why Parents Say No To Having Their Children Vaccinated Against Measles: A Systematic Review Of The Social Determinants Of Parental Perceptions And Family Approaches To Addressing Mmr Vaccine Hesitancy, M. Lelinneth B. Novilla, Michael C. Goates, Mallory Showalter, L. Kirsten Novilla, Russell Doria, Michael Dang, Katelyn Aldridge, Tyler Leffler

Library/Life Sciences Undergraduate Poster Competition 2020

The increase in vaccine-preventable disease (VPD) outbreaks has caused great alarm to the public health community. While national and state immunization coverages remain high, the resurgence of measles points to local pockets of under-vaccination that coincide with higher parental vaccine hesitancy and more non-medical exemptions.

According to the World Health Organization (WHO), vaccine hesitancy is the “delay in acceptance or refusal of vaccines despite availability of vaccination services” and is problematic for highly contagious diseases like measles. Without adequate vaccination coverage to establish herd immunity, person-to-person transmission is facilitated, particularly in under-vaccinated communities. Central to the discussion about measles resurgence ...


Galectin-1: A Potential Protein Therapy For Limb-Girdle Muscular Dystrophy 2b, Mary L. Vallecillo, Matthew S. Teynor, Jonard C. Valdoz, Spencer D. Hayes, P. Daniel Poulson, Matthew F. Rathgeber, Sean R. Stowell, Pam M. Van Ry Apr 2020

Galectin-1: A Potential Protein Therapy For Limb-Girdle Muscular Dystrophy 2b, Mary L. Vallecillo, Matthew S. Teynor, Jonard C. Valdoz, Spencer D. Hayes, P. Daniel Poulson, Matthew F. Rathgeber, Sean R. Stowell, Pam M. Van Ry

Library/Life Sciences Undergraduate Poster Competition 2020

  • Limb-Girdle Muscular Dystrophy 2B (LGMD2B) belongs to a group of diseases called dysferlinopathies, caused by mutations in the DYSF gene.
  • Dysferlin is an important muscle membrane protein involved in repair and regeneration after injury.
  • LGMD2B causes muscle wasting, fat infiltration, and loss of ambulation in patients.
  • Currently there is no cure and few treatment options.
  • Galectin-1 is a small protein that interacts with glycosylated proteins. It shows efficacy in treating murine models of Duchenne Muscular Dystrophy.
  • Here we explore the ability of recombinant human Galectin-1 (rHsGal-1) to ameliorate disease pathologies and mechanisms of LGMD2B

Hypothesis: Recombinant human galectin-1 (rHsGal-1) protein ...