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2013

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Articles 1 - 30 of 9674

Full-Text Articles in Life Sciences

Crowdfunding For Biotechs: How The Sec’S Proposed Rule May Undermine Capital Formation For Startups, Brian J. Farnkoff Dec 2013

Crowdfunding For Biotechs: How The Sec’S Proposed Rule May Undermine Capital Formation For Startups, Brian J. Farnkoff

Journal of Contemporary Health Law & Policy (1985-2015)

No abstract provided.


High Corticosterone, Not High Energy Cost, Correlates With Reproductive Success In The Burrow-Nesting Ancient Murrelet, Akiko Shoji, Kyel Elliot, Kathleen O'Reilly, Anthony Gaston Dec 2013

High Corticosterone, Not High Energy Cost, Correlates With Reproductive Success In The Burrow-Nesting Ancient Murrelet, Akiko Shoji, Kyel Elliot, Kathleen O'Reilly, Anthony Gaston

Biology Faculty Publications and Presentations

Theory and observations suggest that offspring abandonment in animals may occur when the costs to future reproductive output of current reproductive effort outweigh the fitness benefits of rearing the current brood. While hormonal cues (i.e. corticosterone) or energy reserves are believed to be involved, few studies have directly focused on the proximate cues influencing behaviours directly related to reproductive success. To address this information gap, we determined the incubation metabolic rates and corticosterone (CORT) levels of naturally fasting and freely incubating ancient murrelets (Synthliboramphus antiquus). Respiratory quotient (RQ) increased with date, suggesting that incubating ancient murrelets shifted from strictly ...


Partitioning The Fitness Components Of Rna Populations Evolving In Vitro, Carolina Diaz Arenas, Niles Lehman Dec 2013

Partitioning The Fitness Components Of Rna Populations Evolving In Vitro, Carolina Diaz Arenas, Niles Lehman

Chemistry Faculty Publications and Presentations

All individuals in an evolving population compete for resources, and their performance is measured by a fitness metric. The performance of the individuals is relative to their abilities and to the biotic surroundings – the conditions under which they are competing – and involves many components. Molecules evolving in a test tube can also face complex environments and dynamics, and their fitnessmeasurements should reflect the complexity of various contributing factors as well. Here, the fitnesses of a set of ligase ribozymes evolved by the continuous in vitroevolution system were measured. During these evolution cycles there are three different catalytic steps, ligation ...


U.S. Drought Monitor, December 31, 2013, Matthew Rosencrans Dec 2013

U.S. Drought Monitor, December 31, 2013, Matthew Rosencrans

US Ag in Drought Archive

Drought map of U.S. for December 31, 2013 (12/31/13) plus: U.S. crop areas experiencing drought (map), Approximate percentage of crop located in drought, by state (bar graph), Percent of crop area located in drought, past 52 weeks (line graph) for: Corn, Soybeans, Hay, Cattle, Winter wheat.


The Regulation Of Prospore Membrane Shape In Saccharomyces Cerevisiae, Emily M. Parodi Dec 2013

The Regulation Of Prospore Membrane Shape In Saccharomyces Cerevisiae, Emily M. Parodi

Graduate Doctoral Dissertations

The size and shape of a membrane is an important determinant in cell morphology. My work focuses on how membrane size and shape is determined, using the budding yeast S. cerevisiae as a model. During sporulation in S. cerevisiae, the diploid cell remodels its interior such that four spores are formed within an ascus. During this remodeling process, the prospore membrane is synthesized de novo and grows to surround each of the meiotic products. The prospore membrane is a double lipid bilayer and ultimately determines the sizes and shapes of the newly formed spores. My work focuses on the Pleckstrin ...


The Effects Of Nesting Environment On Neonatal Hypoxic-Ischemic Injury, Laura Grace Rollins Dec 2013

The Effects Of Nesting Environment On Neonatal Hypoxic-Ischemic Injury, Laura Grace Rollins

Graduate Masters Theses

Term neonates with hypoxic-ischemic (HI) injury are at risk for devastating neurological sequelae. The objective of this study is to determine if altering the early environment for maternal care-taking impacts the immediate and long-term sequelae of HI offspring. The Rice-Vannucci model was used to induce HI in postnatal day (PND) 7 Long-Evans pups. Litters were assigned to a closed nest (CN) or normal standard housing (SH) condition. Neurobehavioral development, cognitive ability, and stress response were assessed to establish any benefits of the CN condition. Finally, postmortem brain tissue was analyzed for morphometric markers of injury.


Duration Of Untreated Psychosis Is Associated With Temporal And Occipitotemporal Gray Matter Volume Decrease In Treatment Naive Schizophrenia, Xiaofeng Guo, Jun Li, Qinling Wei, Xiaoduo Fan, David N. Kennedy, Yidong Shen, Huafu Chen, Jingping Zhao Dec 2013

Duration Of Untreated Psychosis Is Associated With Temporal And Occipitotemporal Gray Matter Volume Decrease In Treatment Naive Schizophrenia, Xiaofeng Guo, Jun Li, Qinling Wei, Xiaoduo Fan, David N. Kennedy, Yidong Shen, Huafu Chen, Jingping Zhao

University of Massachusetts Medical School Faculty Publications

BACKGROUND: Long duration of untreated psychosis (DUP) is associated with poor treatment outcome. Whether or not DUP is related to brain gray matter volume abnormalities in antipsychotic medication treatment naive schizophrenia remains unclear at this time.

METHODS: Patients with treatment-naive schizophrenia and healthy controls went through brain scan using high resolution Magnetic Resonance Imaging. DUP was evaluated using the Nottingham Onset Schedule (NOS), and dichotomized as short DUP ( 26 weeks). Voxel-based methods were used for volumetric measure in the brain.

RESULTS: Fifty-seven patients (27 short DUP and 30 long DUP) and 30 healthy controls were included in the analysis. There ...


The Processing Of Amyloid Precursor Protein In The Central Nervous System Of Humans And Rhesus Macaques, Justyna Anna Dobrowolska Dec 2013

The Processing Of Amyloid Precursor Protein In The Central Nervous System Of Humans And Rhesus Macaques, Justyna Anna Dobrowolska

All Theses and Dissertations (ETDs)

Alzheimer's disease: AD) is the most common dementia, currently afflicting 30 million people worldwide, with prevalence steadily increasing. Over 99% of AD cases are classified as sporadic, in which the major risk factors are age: greater than 65 years) and the ApoE-ε4 allele: in a gene dose dependent manner). The minority of AD cases: less than 1%) are caused by autosomal dominant inheritance of a genetic mutation in one of three genes: Amyloid Precursor Protein: APP), Presenilin-1: PSEN1), or Presenilin-2: PSEN2). Mutation carriers will generally notice cognitive decline starting at a relatively young age, anytime between their 30s-50s, and ...


Net Primary Productivity Of Subalpine Meadows In Yosemite National Park In Relation To Climate Variability, Peggy E. Moore, Jan W. Van Wagtendonk, Julie L. Yee, Mitchel P. Mcclaran, David N. Cole, Neil K. Mcdougald, Matthew L. Brooks Dec 2013

Net Primary Productivity Of Subalpine Meadows In Yosemite National Park In Relation To Climate Variability, Peggy E. Moore, Jan W. Van Wagtendonk, Julie L. Yee, Mitchel P. Mcclaran, David N. Cole, Neil K. Mcdougald, Matthew L. Brooks

Western North American Naturalist

Subalpine meadows are some of the most ecologically important components of mountain landscapes, and primary productivity is important to the maintenance of meadow functions. Understanding how changes in primary productivity are associated with variability in moisture and temperature will become increasingly important with current and anticipated changes in climate. Our objective was to describe patterns and variability in aboveground live vascular plant biomass in relation to climatic factors. We harvested aboveground biomass at peak growth from four 64-m2 plots each in xeric, mesic, and hydric meadows annually from 1994 to 2000. Data from nearby weather stations provided independent variables ...


Rodent-Mediated Interactions Among Seed Species Of Differing Quality In A Shrubstepe Ecosystem, Karen H. Beard, Craig A. Faulhaber, Frank P. Howe, Thomas C. Edwards Jr. Dec 2013

Rodent-Mediated Interactions Among Seed Species Of Differing Quality In A Shrubstepe Ecosystem, Karen H. Beard, Craig A. Faulhaber, Frank P. Howe, Thomas C. Edwards Jr.

Western North American Naturalist

Interactions among seeds, mediated by granivorous rodents, are likely to play a strong role in shrubsteppe ecosystem restoration. Past studies typically consider only pairwise interactions between preferred and less preferred seed species, whereas rangeland seedings are likely to contain more than 2 seed species, potentially leading to complex interactions. We examined how the relative proportion of seeds in a 3-species polyculture changes rodent seed selectivity (i.e., removal) and indirect interactions among seeds. We presented 2 rodent species, Peromyscus maniculatus (deer mice) andPerognathus parvus (pocket mice), in arenas with 3-species seed mixtures that varied in the proportion of a ...


Long-Distance Movement In A Dusky Great Horned Owl And Limits To Phylogeography For Establishing Provenance, Robert W. Dickerman, Sabrina M. Mcnew, Christopher C. Witt Dec 2013

Long-Distance Movement In A Dusky Great Horned Owl And Limits To Phylogeography For Establishing Provenance, Robert W. Dickerman, Sabrina M. Mcnew, Christopher C. Witt

Western North American Naturalist

The Dusky Great Horned Owl (Bubo virginianus saturatus) of the Pacific Northwest region of North America is generally considered to be nonmigratory. Here we report a specimen of a Dusky Great Horned Owl that was salvaged in New Mexico and identified based on comparison of its plumage with a large series of museum skins. We attempted to corroborate this identification by comparing mitochondrial DNA sequences between the specimen and a representative sample of 5 Great Horned Owl subspecies from western North America. This analysis revealed minimal mitochondrial genetic variation and no evidence of population genetic structure, suggesting that the marked ...


Insect Prey Eaten By Hoary Bats (Lasiurus Cinereus) Prior To Fatal Collisions With Wind Turbines, Ernest W. Valdez, Paul M. Cryan Dec 2013

Insect Prey Eaten By Hoary Bats (Lasiurus Cinereus) Prior To Fatal Collisions With Wind Turbines, Ernest W. Valdez, Paul M. Cryan

Western North American Naturalist

Wind turbines are being deployed all across the world to meet the growing demand for energy, and in many areas, these turbines are causing the deaths of insectivorous migratory bats. One of the hypothesized causes of bat susceptibility is that bats are attracted to insects on or near the turbines. We examined insect remains in the stomachs and intestines of hoary bats (Lasiurus cinereus) found dead beneath wind turbines in New York and Texas to evaluate the hypothesis that bats die while feeding at turbines. Most of the bats we examined had full stomachs, indicating that they fed in the ...


Evaluating Survival Of Greater Sage-Grouse Chicks In Strawberry Valley, Utah, By Use Of Microtransmitters: Does Handling Time Negatively Influence Survival Rates?, Jared J. Baxter, Jordan P. Hennefer, Rick J. Baxter, Randy T. Larsen, Jerran T. Flinders Dec 2013

Evaluating Survival Of Greater Sage-Grouse Chicks In Strawberry Valley, Utah, By Use Of Microtransmitters: Does Handling Time Negatively Influence Survival Rates?, Jared J. Baxter, Jordan P. Hennefer, Rick J. Baxter, Randy T. Larsen, Jerran T. Flinders

Western North American Naturalist

Research indicates that low nest success and juvenile survival may be factors contributing to Greater Sage-Grouse population declines. Recent technological advances in microtransmitters have allowed researchers to monitor individual chicks and broods. We initiated a chick survival study in 2006 and used microtransmitters to (1) examine the viability of using microtransmitters on chicks to assess survival, including the effect of handling time during the suturing process; (2) estimate overall chick survival; and (3) compare chick survival in the Strawberry Valley population to other published reports. We used a known-fate model in program MARK to estimate ĉ (overdispersion), weekly survival rates ...


Seasonal Habitat Selection By Elk In North Central Utah, Jeffrey L. Beck, Kurt T. Smith, Jerran T. Flinders, Craig L. Clyde Dec 2013

Seasonal Habitat Selection By Elk In North Central Utah, Jeffrey L. Beck, Kurt T. Smith, Jerran T. Flinders, Craig L. Clyde

Western North American Naturalist

Understanding anthropogenic and environmental factors that influence seasonal habitat selection is critical in establishing conservation objectives for wildlife populations. However, many resource selection studies provide inferences only for single seasons, potentially masking factors essential to populations during other times of the year. Our objective was to model elk (Cervus elaphus) habitat selection for 4 seasons to identify factors influencing selection within and across seasons. Using aerial relocation data, we evaluated seasonal habitat selection for 46 radio-marked, migratory adult female elk in a 6123-km2 landscape in north central Utah, USA, from 1993 to 1997. We evaluated habitat use and availability ...


Impacts From Winter–Early Spring Elk Grazing In Foothills Rough Fescue Grassland, Tanya M. Thrift, Tracy K. Mosley, Jeffrey C. Mosley Dec 2013

Impacts From Winter–Early Spring Elk Grazing In Foothills Rough Fescue Grassland, Tanya M. Thrift, Tracy K. Mosley, Jeffrey C. Mosley

Western North American Naturalist

Foothills rough fescue (Festuca campestris) grasslands provide important foraging habitat for wildlife and livestock in the northwestern United States and southwestern Canada. Foothills rough fescue is sensitive to grazing during late spring–early summer but is believed to be more tolerant of grazing during winter–early spring. We evaluated vegetation and soil impacts from long-term winter–early spring grazing at 2 intensities (HG = heavy grazing, LG = light grazing). We studied a foothills rough fescue grassland in west central Montana, USA, that had been grazed almost exclusively by Rocky Mountain elk (Cervus elaphus nelsoni) during winter–early spring for 58 years ...


An Arizona Bark Scorpion (Centruroides Sculpturatus) Found Consuming A Venomous Prey Item Nearly Twice Its Length, Michael M. Webber, Matthew R. Graham Dec 2013

An Arizona Bark Scorpion (Centruroides Sculpturatus) Found Consuming A Venomous Prey Item Nearly Twice Its Length, Michael M. Webber, Matthew R. Graham

Western North American Naturalist

Arizona bark scorpions (Centruroides sculpturatus Ewing) are commonly found throughout the Sonoran Desert in southwestern North America, and they are well known for being the most venomous scorpion in the United States. Despite their medical significance, C. sculpturatus remains ecologically understudied, and little is known regarding its natural foraging and feeding behaviors. Here, we present the first documented case of C. sculpturatus feeding on the Sonoran Desert centipede (Scolopendra polymorpha Wood) in the wild.


Los Alacranes de Corteza de Arizona (Centruroides sculpturatus Ewing), por lo general, se encuentran en todo el Desierto de Sonora, en el sudoeste de Norteamérica, y ...


Impact Of Livestock Grazing On Plant And Small Mammal Communities In The Ruby Mountains, Northeastern Nevada, Eric A. Rickart, Klaus G. Bienek, Rebecca J. Rowe Dec 2013

Impact Of Livestock Grazing On Plant And Small Mammal Communities In The Ruby Mountains, Northeastern Nevada, Eric A. Rickart, Klaus G. Bienek, Rebecca J. Rowe

Western North American Naturalist

We assessed the effects of livestock grazing on vegetation and small mammals in semiarid habitat at a site in northeastern Nevada. Habitat within a fenced exclosure that had been protected from grazing for more than 50 years supported more vegetation and had greater plant diversity compared to habitat immediately outside the exclosure. Likewise, species richness and abundance of small mammals were greater in ungrazed areas. Results suggest that grazing regulation in recent decades may account for some of the changes seen in regional plants and small mammals over the past century. The incorporation of long-term exclosures in a comparative framework ...


New Records Of Marginal Locations For American Pika (Ochotona Princeps) In The Western Great Basin, Constance I. Millar, Robert D. Westfall, Diane L. Delany Dec 2013

New Records Of Marginal Locations For American Pika (Ochotona Princeps) In The Western Great Basin, Constance I. Millar, Robert D. Westfall, Diane L. Delany

Western North American Naturalist

We describe 46 new site records documenting occupancy by American pika (Ochotona princeps) at 21 locations from 8 mountain regions in the western Great Basin, California, and Nevada. These locations comprise a subset of sites selected from regional surveys to represent marginal, isolated, or otherwise atypical pika locations, and to provide information for assessing environmental tolerance limits. Several locations are known from historic observations (Madeline Plain, Bodie Mtns., Wassuk Mtns., Mono Craters) and are included here to update current status. Site elevations range from 1848 m to 3392 m; relative to the broad range of pika sites in the region ...


Helminths Of The Speckled Rattlesnake, Crotalus Mitchellii (Squamata: Viperidae), Stephen R. Goldberg, Charles R. Bursey, Xavier Glaudas Dec 2013

Helminths Of The Speckled Rattlesnake, Crotalus Mitchellii (Squamata: Viperidae), Stephen R. Goldberg, Charles R. Bursey, Xavier Glaudas

Western North American Naturalist

Fifty-six speckled rattlesnakes, Crotalus mitchellii, from western North America were examined for helminths. One species of Cestoda (tetrathyridia of Mesocestoides sp.) and 5 species of Nematoda (gravid adults of Abbreviata terrapenis, Physaloptera abjecta, Thubunaea cnemidophorus, and Travassoascaris araujoi and larvae ofPhysocephalus sp.) were found. Travassoascaris araujoi had the highest prevalence and greatest mean intensity of helminths infecting C. mitchellii. Three new host records forC. mitchellii are reported. As has been reported for other North American rattlesnakes,C. mitchellii is parasitized by “generalist” helminths.


Cincuenta y seis Viboras de Cascabel (Cascabeles Pintítas, Crotalus mitchellii) del oeste de América del ...


End Matter, Vol. 73 No. 4 Dec 2013

End Matter, Vol. 73 No. 4

Western North American Naturalist

No abstract provided.


Seed-Feeding Beetles (Bruchinae, Curculionidae, Brentidae) From Legumes (Dalea Ornata, Astragalus Filipes) And Other Forbs Needed For Restoring Rangelands Of The Intermountain West, James H. Cane, Clarence Johnson, Jesus Romero Napoles, Douglas A. Johnson, Robert Hammon Dec 2013

Seed-Feeding Beetles (Bruchinae, Curculionidae, Brentidae) From Legumes (Dalea Ornata, Astragalus Filipes) And Other Forbs Needed For Restoring Rangelands Of The Intermountain West, James H. Cane, Clarence Johnson, Jesus Romero Napoles, Douglas A. Johnson, Robert Hammon

Western North American Naturalist

Seed-feeding beetles of the genera Acanthoscelides, Apion, and occasionally Tychiuswere commonly found occurring in seeds from wild populations of Astragalus filipesand Dalea ornata across rangelands of the United States Intermountain West, resulting in many new state, county, and host records. These 2 legumes, as well as other perennial herbaceous species, are being commercially farmed to produce seed supplies to rehabilitate sagebrush-steppe and adjoining juniper woodlands following wildfires. Most of the seeds examined in this study hosted one or more seed-feeding beetles; beetles that pupate and overwinter in the seeds pose the risk of being transported to storage warehouses ...


Influence Of Boulders On Netleaf Hackberry (Celtis Reticulata) Growth And Distribution In The Wasatch Foothills, Alex Argyle, Michael T. Stevens Dec 2013

Influence Of Boulders On Netleaf Hackberry (Celtis Reticulata) Growth And Distribution In The Wasatch Foothills, Alex Argyle, Michael T. Stevens

Western North American Naturalist

In a landscape, abiotic features, such as boulders, influence microhabitats and consequently affect patterns of vegetation. We hypothesized that boulders in the foothills of the Wasatch Mountains east of Provo, Utah, affected the growth patterns of netleaf hackberry (Celtis reticulata) by providing shade on their north faces. To test this hypothesis, we set up 3 transects 6 m wide and up to 50 m long. Along these transects, we measured all hackberries taller than 30 cm (n = 249). We recorded whether the hackberries grew within 0.5 m of a boulder that was at least 0.5 m along one ...


Outstanding Natural History Paper Of 2012 Dec 2013

Outstanding Natural History Paper Of 2012

Western North American Naturalist

The winning paper is "Site-occupancy monitoring of an ecosystem indicator: linking characteristics of riparian vegetation to beaver occurrence" by Stewart W. Breck, Michael I. Goldstein, and Sanjay Pyare (WNAN 72:432–441).


Front Matter, Vol. 73 No. 4 Dec 2013

Front Matter, Vol. 73 No. 4

Western North American Naturalist

No abstract provided.


Comparison Of Different Differential Expression Analysis Tools For Rna-Seq Data, Junfei Zhu Dec 2013

Comparison Of Different Differential Expression Analysis Tools For Rna-Seq Data, Junfei Zhu

Theses

In molecular biology research, RNA-seq is a relatively new method for transcriptome profiling. It utilizes the next generation sequencing technology to provide huge amount information about the variety and abundance of RNA present in an organism of interest at a specific state and a given time. One of the most important tasks of RNA-seq analysis is finding genes that are expressed differently in different subject groups. A lot of differential expression analysis tools for RNA-seq have been developed, but there is no golden standard in this field. In this research, four commonly used tools (DESeq, edgeR, limma, and cuffdiff) are ...


The Global Translation Profile In A Ribosomal Protein Mutant Resembles That Of An Eif3 Mutant, Bayu Sisay Tiruneh, Byung-Hoon Kim, Daniel R. Gallie, Bijoyita Roy, Albrecht G. Von Arnim Dec 2013

The Global Translation Profile In A Ribosomal Protein Mutant Resembles That Of An Eif3 Mutant, Bayu Sisay Tiruneh, Byung-Hoon Kim, Daniel R. Gallie, Bijoyita Roy, Albrecht G. Von Arnim

Faculty Publications and Other Works -- Biochemistry, Cellular and Molecular Biology

Background

Genome-wide assays performed in Arabidopsis and other organisms have revealed that the translation status of mRNAs responds dramatically to different environmental stresses and genetic lesions in the translation apparatus. To identify additional features of the global landscape of translational control, we used microarray analysis of polysomal as well as non-polysomal mRNAs to examine the defects in translation in a poly(A) binding protein mutant, pab2 pab8, as well as in a mutant of a large ribosomal subunit protein, rpl24b/shortvalve1.

Results

The mutation of RPL24B stimulated the ribosome occupancy of mRNAs for nuclear encoded ribosomal proteins. Detailed analysis yielded ...


2013 Oregon Wine Harvest Report, Oregon Wine Board Dec 2013

2013 Oregon Wine Harvest Report, Oregon Wine Board

Oregon Wine Board Documents

This harvest report for the Oregon wine industry from 2013 describes the season as "a play in two acts, with a wet intermission." Vintners were surprised by record rainfall one weekend in late September after a warm and dry summer. The rains, remnants from a typhoon in Japan, mostly affected the Willamette Valley, but effects were variable even within that region; southern and eastern Oregon were less affected by the storm.


Novel And Predominant Pathogen Responsible For The Enterovirus-Associated Encephalitis In Eastern China, Lei Zhang, Jie Yan, David M. Ojcius, Huakun Lv, Ziping Miao, Yin Chen, Yanjun Zhang, Jvying Yan Dec 2013

Novel And Predominant Pathogen Responsible For The Enterovirus-Associated Encephalitis In Eastern China, Lei Zhang, Jie Yan, David M. Ojcius, Huakun Lv, Ziping Miao, Yin Chen, Yanjun Zhang, Jvying Yan

Dugoni School of Dentistry Faculty Articles

Enteroviruses (EV) have been increasingly identified as the causative agent for unknown etiological encephalitis in many parts of the world, but the long period surveillance for enterovirus-associated encephalitis (EAE) was not reported in China. From 2002-2012 in Zhejiang, Coxsackieviruses A9, B1, B2, B3, B4, B5; and echoviruses 3, 4, 6, 9, 14, 25, 30 were detected from the unknown etiological encephalitis cases, with coxsackievirus B4 been identified here for the first time. From 2002-2004 and 2010-2012, echovirus 30 was found to be the periodically predominant serotype for in the EAE. The molecular typing results showed that all the EV isolates ...


The Global Translation Profile In A Ribosomal Protein Mutant Resembles That Of An Eif3 Mutant, Bayu Sisay Tiruneh, Byung-Hoon Kim, Daniel R. Gallie, Bijoyita Roy, Albrecht G. Von Arnim Dec 2013

The Global Translation Profile In A Ribosomal Protein Mutant Resembles That Of An Eif3 Mutant, Bayu Sisay Tiruneh, Byung-Hoon Kim, Daniel R. Gallie, Bijoyita Roy, Albrecht G. Von Arnim

Open Access Articles

BACKGROUND: Genome-wide assays performed in Arabidopsis and other organisms have revealed that the translation status of mRNAs responds dramatically to different environmental stresses and genetic lesions in the translation apparatus. To identify additional features of the global landscape of translational control, we used microarray analysis of polysomal as well as non-polysomal mRNAs to examine the defects in translation in a poly(A) binding protein mutant, pab2 pab8, as well as in a mutant of a large ribosomal subunit protein, rpl24b/shortvalve1.

RESULTS: The mutation of RPL24B stimulated the ribosome occupancy of mRNAs for nuclear encoded ribosomal proteins. Detailed analysis yielded ...


The Neighborhood Energy Balance Equation: Does Neighborhood Food Retail Environment + Physical Activity Environment = Obesity? The Cardia Study, Janne Boone-Heinonen, Ana V. Diez-Roux, David C. Goff, Catherine M. Loria, Catarina I. Kiefe, Barry M. Popkin, Penny Gordon-Larsen Dec 2013

The Neighborhood Energy Balance Equation: Does Neighborhood Food Retail Environment + Physical Activity Environment = Obesity? The Cardia Study, Janne Boone-Heinonen, Ana V. Diez-Roux, David C. Goff, Catherine M. Loria, Catarina I. Kiefe, Barry M. Popkin, Penny Gordon-Larsen

University of Massachusetts Medical School Faculty Publications

BACKGROUND: Recent obesity prevention initiatives focus on healthy neighborhood design, but most research examines neighborhood food retail and physical activity (PA) environments in isolation. We estimated joint, interactive, and cumulative impacts of neighborhood food retail and PA environment characteristics on body mass index (BMI) throughout early adulthood.

METHODS AND FINDINGS: We used cohort data from the Coronary Artery Risk Development in Young Adults (CARDIA) Study [n=4,092; Year 7 (24-42 years, 1992-1993) followed over 5 exams through Year 25 (2010-2011); 12,921 person-exam observations], with linked time-varying geographic information system-derived neighborhood environment measures. Using regression with fixed effects for ...