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Graduate Theses and Dissertations

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Full-Text Articles in Life Sciences

Validating The Accuracy Of Neatwork, A Rural Gravity Fed Water Distribution System Design Program, Using Field Data In The Comarca Ngöbe-Bugle, Panama, Maria Briones Jul 2018

Validating The Accuracy Of Neatwork, A Rural Gravity Fed Water Distribution System Design Program, Using Field Data In The Comarca Ngöbe-Bugle, Panama, Maria Briones

Graduate Theses and Dissertations

Despite the sustainable development goals to increase access to improved water there are still 884 million people in the world without access to an improved water source (WHO, 2017). One method to improve access to water in rural, mountainous areas, is through construction of gravity fed water distribution systems. These systems should be designed based upon fundamental principles of hydraulics. One method of doing so in a time efficient manner with minimal engineering knowledge is to utilize a downloadable computer program such as Neatwork, which aids in design of rural, gravity fed water distribution systems and has been used by ...


The Role Of Pulmonary Stretch Receptor Afferents In Swallow-Breathing Coordination: A Comparison Of Central Respiratory Rhythm Versus Mechanical Ventilation On Swallow In A Decerebrate Feline Model, Kofi-Kermit A. Horton Jul 2018

The Role Of Pulmonary Stretch Receptor Afferents In Swallow-Breathing Coordination: A Comparison Of Central Respiratory Rhythm Versus Mechanical Ventilation On Swallow In A Decerebrate Feline Model, Kofi-Kermit A. Horton

Graduate Theses and Dissertations

Swallowing is an essential motor act that coordinates the movement of food or saliva from the mouth through the pharynx and into the esophagus while protecting the upper airways from aspiration of those materials. Disordered swallowing, or dysphagia, results when bolus movement from the oropharyngeal phase into the esophageal phase is uncoordinated. Dysphagia directly causes or increases the risk of aspiration during swallowing in many clinical pathologies including Parkinson’s disease, Alzheimer’s disease, cerebrovascular incidents (stroke) in addition to being prevalent among the elderly population. The coordination between breathing and swallowing is mediated through the interaction of the swallow ...


The Nutrition Transition Among The Andean Kichwas Of Ecuador, Vanessa Alicia Chee Jun 2018

The Nutrition Transition Among The Andean Kichwas Of Ecuador, Vanessa Alicia Chee

Graduate Theses and Dissertations

The nutrition transition is a global phenomenon in which diets have become increasingly westernized and processed while lifestyles have shifted from labor intensive to sedentary, largely on account of the advent of technology, globalization n and urbanization. Despite the prevalence of this phenomenon, very little is known regarding how the nutrition transition has affected the risk of comorbid chronic diseases among indigenous Kichwas communities in Ecuador. Aims of this study are : 1) Identify specific health outcomes (such as diabetes, hypertension, and high cholesterol) associated with the lifestyle risk factors of the nutrition transition among the Andean Kichwas indigenous population; 2 ...


Intraspecific Variation In The Recruitment Dynamics Of A Transgressing Avicennia Germinans Population, Shannon Victoria Grogan Jun 2018

Intraspecific Variation In The Recruitment Dynamics Of A Transgressing Avicennia Germinans Population, Shannon Victoria Grogan

Graduate Theses and Dissertations

Survival and establishment of mangrove propagules at higher tidal elevations beyond the landward margin of their distribution is a requirement for the continued existence of mangrove populations in response to rising sea-level. Despite the growing body of literature that discusses mangrove recruitment patterns, few studies have empirically examined establishment and post-establishment growth success of propagules at the higher intertidal positions into witch mangrove populations are migrating. Using an experimental field approach, this study compares establishment and post-establishment growth success of propagules at three positions across a tidal elevation gradient within a landward-transgressing mangrove population of SW Florida (USA). I observed ...


Ecophysiology Of Oxygen Supply In Cephalopods, Matthew A. Birk Jun 2018

Ecophysiology Of Oxygen Supply In Cephalopods, Matthew A. Birk

Graduate Theses and Dissertations

Cephalopods are an important component of many marine ecosystems and support large fisheries. Their active lifestyles and complex behaviors are thought to be driven in large part by competition with fishes. Although cephalopods appear to compete successfully with fishes, a number of their important physiological traits are arguably inferior, such as an inefficient mode of locomotion via jet propulsion and a phylogenetically limited means of blood-borne gas transport. In active shallow-water cephalopods, these traits result in an interesting combination of very high oxygen demand and limited oxygen supply. The ability to maintain active lifestyles despite these metabolic constraints makes cephalopods ...


Quantitative Proteomics To Support Translational Cancer Research, Melissa Hoffman Jun 2018

Quantitative Proteomics To Support Translational Cancer Research, Melissa Hoffman

Graduate Theses and Dissertations

Altered signaling pathways, which are mediated by post-translational modifications and changes in protein expression levels, are key regulators of cancer initiation, progression, and therapeutic escape. Many aspects of cancer progression, including early carcinogenesis and immediate response to drug treatment, are beyond the scope of genetic profiling and non-invasive monitoring techniques. Global protein profiling of cancer cell line models, tumor tissues, and biofluids (e.g. serum or urine) using mass spectrometry-based proteomics produces novel biological insights, which support improved patient outcomes. Recent technological advances resulting in next-generation mass spectrometry instrumentation and improved bioinformatics workflows have led to unprecedented measurement reproducibility as ...


Synthesis, Oxidation, And Distribution Of Polyphenols In Strawberry Fruit During Cold Storage, Katrina E. Kelly Jun 2018

Synthesis, Oxidation, And Distribution Of Polyphenols In Strawberry Fruit During Cold Storage, Katrina E. Kelly

Graduate Theses and Dissertations

Plants inherently produce polyphenols (i.e., antioxidants) as a response to reduce oxidative stress caused by abusive environmental pre- and postharvest conditions. These antioxidants, as well as vitamin C, are present in considerable levels in strawberries; however, excessive oxidative stress brought on by improper postharvest handling conditions can reduce the levels of antioxidants in the fruit and shorten the shelf-life of strawberries. Nevertheless, it may be possible to utilize strawberry’s naturally occurring polyphenols to reduce postharvest stress and extend their shelf life. The polyphenolic profile has been previously investigated in several strawberry cultivars, however no studies have determined the ...


Understanding Agricultural-Land Conservation From The Perspective Of Landowners In Franklin County, Massachusetts, Rocio Lalanda Jun 2018

Understanding Agricultural-Land Conservation From The Perspective Of Landowners In Franklin County, Massachusetts, Rocio Lalanda

Graduate Theses and Dissertations

What motivates agricultural-land owners to use conservation easements? As these legal tools have become a popular strategy for private land conservation in the U.S., a growing body of literature is examining how and why landowners conserve their properties through conservation easements. This research project expands upon environmental, geographical and rural land development literature through a qualitative fieldwork study of 34 private, conservation landowners associated with the Franklin Land Trust, a nonprofit conservation organization in western Massachusetts. The study identifies a broad range of environmental, social, spiritual and financial motivations for agricultural-land owners to conserve their properties, and indicates that ...


Microbial Associations Of Four Species Of Algal Symbiont-Bearing Foraminifera From The Florida Reef Tract, Usa, Makenna May Martin Jun 2018

Microbial Associations Of Four Species Of Algal Symbiont-Bearing Foraminifera From The Florida Reef Tract, Usa, Makenna May Martin

Graduate Theses and Dissertations

Marine microbiome research is a rapidly expanding field of study, as scientists investigate the functions of microbial associations in eukaryotic organisms. Foraminifera are among the most abundant shelled organisms in the oceans, yet little is known of their associated microbiomes. This study investigated microbes associated with four species of Foraminifera that host three kinds of algal endosymbionts. The Order Miliolida, Family Soritidae, was represented by three species: Archaias angulatus and Cyclorbiculina compressa, which both host chlorophyte symbionts, and Sorites orbiculus, which hosts dinoflagellate symbionts. The fourth species, Amphistegina gibbosa, belongs to the Order Rotaliida and hosts diatom endosymbionts. Bacterial DNA ...


Do All “Good Mothers” Breastfeed? How African American Mothers’ Values And Experiences Of Early Motherhood Influence Their Infant Feeding Choices, Airia S. Papadopoulos May 2018

Do All “Good Mothers” Breastfeed? How African American Mothers’ Values And Experiences Of Early Motherhood Influence Their Infant Feeding Choices, Airia S. Papadopoulos

Graduate Theses and Dissertations

The food an infant is fed can reflect many things: a source of nutrition, the social and cultural circumstances into which an infant is born, or even a family’s beliefs about the body and breast milk as a source of nutrition. Exclusive breastfeeding, currently the gold standard for infant feeding in the United States (US), is often identified as an expectation in discourses on being a “good mother.” African American mothers in particular are the least likely group in the US to breastfeed in any capacity and many efforts are underway to increase the breastfeeding rates of this population ...


Identification Of Novel Hits Against, Ala A. Azhari Apr 2018

Identification Of Novel Hits Against, Ala A. Azhari

Graduate Theses and Dissertations

Leishmaniasis is a disease caused by obligate intracellular parasites of the genus Leishmania, including 20 species that are pathogenic to humans. Female sand fly is the known vector that can transmit the disease. Visceral leishmaniasis is the severe form of the disease that affects internal organs and can be fatal with inappropriate diagnosis or treatment. Leishmania donovani is the causative agent of visceral leishmaniasis. Approximately 350 million in 89 countries are at risk of infection. Around 2 million new cases are reported annually with 500,000 of these are visceral leishmaniasis. Current drug therapies are inadequate due to their toxicity ...


The Association Of Size Variation In The Dental Arch To Third Molar Agenesis For A Modern Population, Devin N. Williams Apr 2018

The Association Of Size Variation In The Dental Arch To Third Molar Agenesis For A Modern Population, Devin N. Williams

Graduate Theses and Dissertations

The frequency with which individuals do not develop their third molars, or wisdom teeth, is increasing worldwide. This current topic of human evolution is relevant to the research of anthropologists, geneticists, dentists, and other researchers involved in the study of human dentition. Many explanations have been offered to account for the prevalence of molar agenesis including, evolutionary, environmental, and genetic theories. The purpose of this research project is to determine the frequency of third molar agenesis and investigate the relationship between third molar agenesis and maxillomandibular jaw dimensions in a sample of orthodontic patients. This research tests the hypotheses that ...


Extending Spectrophotometric Pht Measurements In Coastal And Estuarine Environments, Nora Katherine Douglas Apr 2018

Extending Spectrophotometric Pht Measurements In Coastal And Estuarine Environments, Nora Katherine Douglas

Graduate Theses and Dissertations

Nearshore and estuarine environments play a vital role in the cycling of carbon, but the effects of ocean acidification in estuarine waters have not been studied as extensively as in the open ocean. One reason for this is the limitation of pH measurement capabilities in low-salinity waters. Typically, pH in these environments has been measured using potentiometric methods that are subject to uncertainties on the order of 0.01. Spectrophotometric methods for measuring pHT offer precision and accuracy superior to those of potentiometric methods. However, previous characterizations for purified sulfonephthalein indicators, used for marine spectrophotometric measurements, are not applicable to ...


Tgf-Β2 In Human Milk Research: Exploration Of A New Field Methodology And New Findings Of Biosimilar Tgf-Β2 In Non-Human Milk, Chlöe A. Sweetman Apr 2018

Tgf-Β2 In Human Milk Research: Exploration Of A New Field Methodology And New Findings Of Biosimilar Tgf-Β2 In Non-Human Milk, Chlöe A. Sweetman

Graduate Theses and Dissertations

Objectives: There are three aims for this thesis: the first is to develop a field and laboratory protocol for the storage and analysis of transforming growth factor–beta 2 (TGF-β2) in human breastmilk; second, to validate this protocol and the immunoassay used to assess this new method; and lastly, to explore the ramifications of biosimilar TGF-β2 across multiple milks on human health, growth, and immunity through the review of laboratory findings and previous literature.

Rational: Little anthropological research has been done on TGF-β2 in human milk. Anthropology as a discipline is well positioned to provide insight into TGF-β2, combining biocultural ...


Investigation Of Alcohol-Induced Changes In Hepatic Histone Modifications Using Mass Spectrometry Based Proteomics, Crystina Leah Kriss Apr 2018

Investigation Of Alcohol-Induced Changes In Hepatic Histone Modifications Using Mass Spectrometry Based Proteomics, Crystina Leah Kriss

Graduate Theses and Dissertations

Alcohol liver disease (ALD) is a major health concern throughout the world. Currently, in the United States, 17 million people suffer from alcoholism, of which 1.4 million people are receiving treatment [1, 2]. The link between ethanol metabolism, reactive oxygen species (ROS) and liver injury in ALD has been well characterized over the last couple decades [3-10]. Ethanol metabolism relies on the availability of the cofactor NAD+ for the oxidation of ethanol into acetate, consequently causing alterations in redox potential. Redox dysfunction within the mitochondria can affect multiple pathways important in maintaining cellular homeostasis. Chapter 1 provides an introduction ...


The Role Of Phosphohistidine Phosphatase 1 In Ethanol-Induced Liver Injury, Daniel Richard Martin Apr 2018

The Role Of Phosphohistidine Phosphatase 1 In Ethanol-Induced Liver Injury, Daniel Richard Martin

Graduate Theses and Dissertations

Chronic liver diseases, which includes alcoholic liver disease (ALD), are consistently among the top 15 leading causes of death in the United States. ALD is characterized by progression from a normal liver to fatty liver disease (hepatic steatosis), which can lead to cirrhosis, alcoholic hepatitis, and liver failure. We have identified a novel role of phosphohistidine signaling, mediated through phosphohistidine phosphatase 1 (PHPT1), in the onset of hepatic steatosis. We have identified PHPT1 as a target of selective oxidation following acute ethanol exposure as well as being downregulated following chronic ethanol exposure. We mapped the oxidative modification site and developed ...


Signal Detection Of Adverse Drug Reaction Using The Adverse Event Reporting System: Literature Review And Novel Methods, Minh H. Pham Mar 2018

Signal Detection Of Adverse Drug Reaction Using The Adverse Event Reporting System: Literature Review And Novel Methods, Minh H. Pham

Graduate Theses and Dissertations

One of the objectives of the U.S. Food and Drug Administration is to protect the public health through post-marketing drug safety surveillance, also known as Pharmacovigilance. An inexpensive and efficient method to inspect post-marketing drug safety is to use data mining algorithms on electronic health records to discover associations between drugs and adverse events.

The purpose of this study is two-fold. First, we review the methods and algorithms proposed in the literature for identifying association drug interactions to an adverse event and discuss their advantages and drawbacks. Second, we attempt to adapt some novel methods that have been used ...


Remote Sensing And Spatial Metrics For Quantifying Seagrass Landscape Changes: A Study On The 2011 Indian River Lagoon Florida Seagrass Die-Off Event, René Dieter Baumstark Mar 2018

Remote Sensing And Spatial Metrics For Quantifying Seagrass Landscape Changes: A Study On The 2011 Indian River Lagoon Florida Seagrass Die-Off Event, René Dieter Baumstark

Graduate Theses and Dissertations

Florida’s seagrasses are ecologically important marine environments which have suffered major degradation caused by increasing anthropogenic pressures. A 2011 seagrass die-off event caused by an algal bloom in the Florida Indian River Lagoon (IRL) was particularly severe with a majority of seagrass lost in areas such as the Banana River. An understanding of how this coastal marine environment changed is an important step toward better managing resources for conservation. Modern tools and methods provide new opportunities to study these changes at the landscape scale, a scale that informs on the larger more comprehensive state of a system. Classified satellite ...


Comparison Of Thermal Glove Wrist-Hand Orthoses In Their Effectiveness On Rheumatoid Arthritis, Brittany E. Mott Mar 2018

Comparison Of Thermal Glove Wrist-Hand Orthoses In Their Effectiveness On Rheumatoid Arthritis, Brittany E. Mott

Graduate Theses and Dissertations

Rheumatoid arthritis (RA) is an autoimmune disease affecting nearly 1% of the world’s population with symptoms such as inflammation, pain, and reduced strength [1]. Physicians and scientists work to develop pharmaceuticals and medical devices aimed at decreasing the symptoms associated with RA to better the lives of those affected. One of the most recent developments is the addition of thermal therapy gloves to the array of upper limb orthoses available to patients with RA. It was hypothesized that this study will show that orthoses in the form of thermal therapy gloves are beneficial to the patients by reducing symptoms ...


Food Insecurity And Age Of Menarche: Using A Biocultural Approach And Life History Theory To Assess Risks Of Food Insecurity Among Girls In Tampa Bay, Fl, Mecca Burris Mar 2018

Food Insecurity And Age Of Menarche: Using A Biocultural Approach And Life History Theory To Assess Risks Of Food Insecurity Among Girls In Tampa Bay, Fl, Mecca Burris

Graduate Theses and Dissertations

Using life-history theory within a biocultural perspective, this research explores whether household food insecurity correlates with early or delayed menarche among adolescent females in Tampa Bay, Florida. Early onset of puberty and menstruation is connected with numerous health consequences including growth stunting, obesity, type-2 diabetes, adult-onset asthma, reproductive cancers, increased risk for depression, behavioral problems, and early sexual activity which increases the risk for STIs and ovarian cancer. Early menarche also seems to disproportionally impact disadvantaged and minority groups. While there are many known factors that influence age at menarche (e.g.: genetics, diet), little is understood regarding the effect ...


Grooming Behaviors Of, Lauren N. Williams Mar 2018

Grooming Behaviors Of, Lauren N. Williams

Graduate Theses and Dissertations

The giant freshwater shrimp, Macrobrachium rosenbergii is a large species of prawn grown extensively in aquaculture settings. A social hierarchy exists within the males of this species, representing three distinct male morphotypes. These male morphotypes differ in their behavior, physiology, and morphology and include the largest blue-clawed males (BC males), moderately- sized orange-clawed males (OC males), and the undifferentiated small-clawed males (SM males). All individuals of this species perform grooming behaviors to rid themselves of body fouling which can impede important functions such as movement, respiration, chemoreception, and reproduction. Grooming behaviors in crustaceans often utilize specialized structures called setae, which ...


Developing Motion Platform Dynamics For Studying Biomechanical Responses During Exercise For Human Spaceflight Applications, Kaitlin Lostroscio Mar 2018

Developing Motion Platform Dynamics For Studying Biomechanical Responses During Exercise For Human Spaceflight Applications, Kaitlin Lostroscio

Graduate Theses and Dissertations

In future human spaceflight missions, with prolonged exposure to microgravity, resistive and aerobic exercises will be countermeasures for bone loss, muscle loss, and decreased aerobic capacity. Two of the exercises of interest are squats and rowing. The cyclic forces produced during these exercises are at relatively low frequencies which are likely to excite structural resonances of space vehicles. Vibration Isolation Systems (VIS) are being designed to be paired with future exploration exercise devices in order to prevent these cyclic exercise forces from impacting the space vehicle. The VIS may be configured such that a platform supports the human and exercise ...


Angiostrongylus Cantonensis: Epidemiologic Review, Location-Specific Habitat Modelling, And Surveillance In Hillsborough County, Florida, U.S.A., Brad Christian Perich Mar 2018

Angiostrongylus Cantonensis: Epidemiologic Review, Location-Specific Habitat Modelling, And Surveillance In Hillsborough County, Florida, U.S.A., Brad Christian Perich

Graduate Theses and Dissertations

Angiostrongylus cantonensis is a parasitic nematode endemic to tropical and subtropical regions and is the leading cause of human eosinophilic meningitis. The parasite is commonly known as rat lungworm because the primary host in its lifecycle is the rat. A clinical overview of rat lungworm infection is presented, followed by a literature review of rat lungworm epidemiology, risk factors, and surveillance projects. Data collected from previous snail surveys in Florida was considered alongside elevation, population per square kilometer, median household income by zip code territory, and normalized difference vegetation index specific to the geographic coordinates from which the snail samples ...


Characterization Of The Transcriptional Elongation Factor Ell3 In B Cells And Its Role In B-Cell Lymphoma Proliferation And Survival, Lou-Ella M.M. Alexander Jan 2018

Characterization Of The Transcriptional Elongation Factor Ell3 In B Cells And Its Role In B-Cell Lymphoma Proliferation And Survival, Lou-Ella M.M. Alexander

Graduate Theses and Dissertations

The studies presented in this dissertation establish the dynamics of Eleven nineteen Lysine-rich leukemia (ELL) family of elongation factors during B cell differentiation and provide a description of ELL3 function in B cells.

The transition from a mature naïve B cells into an activated B cell is dependent on a large increase in transcriptional output, which is followed by focused expression on secreted immunoglobulin upon terminal differentiation into plasma cell. While ELL family members have previously been implicated in alternative splicing at the immunoglobulin heavy chain locus in plasma cells, their presence and function prior to differentiation is currently not ...


Using Genomic And Gene Expression Methods To Understand The Phenotypic Response Of Soybean To Sudden Death Syndrome Caused By Fusarium Virguliforme, Alexander Stephen Luckew Jan 2018

Using Genomic And Gene Expression Methods To Understand The Phenotypic Response Of Soybean To Sudden Death Syndrome Caused By Fusarium Virguliforme, Alexander Stephen Luckew

Graduate Theses and Dissertations

Soybean sudden death syndrome (SDS) is one of the most important soybean diseases in the Midwestern United States, leading to average losses of $396 million per year from 1996 to 2015. The causal agent of SDS, soilborne fungus Fusarium virguliforme (Fv), causes root rot symptoms and releases phytotoxins taken up by the plant to produce chlorosis and necrosis in the leaves. The main management practice used to reduce the impact of SDS is planting resistant soybean cultivars. Resistance to SDS is known to be quantitative with 88 known quantitative trait loci (QTL) based on Soybase.org. Many of these QTL ...


Migrating And Breeding Bird Use Of Restored Shallow Lakes In Iowa, Rachel Vanausdall Jan 2018

Migrating And Breeding Bird Use Of Restored Shallow Lakes In Iowa, Rachel Vanausdall

Graduate Theses and Dissertations

Large shallow lakes in the Prairie Pothole Region (PPR) have become highly degraded since European settlement. The Shallow Lakes Restoration Program aims to restore Iowa’s shallow lakes to improve water quality and wildlife habitat. The goals of this study were to (1) assess the differences in migrant waterbird species composition, abundance, and diversity in shallow lakes in non-restored, younger, and older states and identify habitat variables that influence migrant waterbirds, (2) quantify the density of breeding marsh birds in shallow lakes in different restoration states, and (3) characterize the vegetation community among shallow lakes in different restoration states. Restored ...


Automated Plant Phenotyping Using 3d Machine Vision And Robotics, Yin Bao Jan 2018

Automated Plant Phenotyping Using 3d Machine Vision And Robotics, Yin Bao

Graduate Theses and Dissertations

With the rapid advancements in genotyping technologies, plant phenotyping has become a bottleneck in exploiting the massive genomic data for crop improvement. The common practice of plant phenotyping relies on human efforts, which is labor-intensive, time-consuming, and prone to human errors. This dissertation documents our innovative research in automated plant phenotyping using 3D machine vision and robotics.

Sorghum and maize are important economic crops for food, feed, fuel, and fiber production. Manipulation of plant architecture plays a vital role in yield improvement via plant breeding. A high-throughput, field-based robotic phenotyping system was developed to characterize plant architecture for tall-growing sorghum ...


Investigating Methods Of Evaluating Swine Feed Additives: Phytase And Alternatives To Antibiotic Growth Promoters, Kristin Olsen Jan 2018

Investigating Methods Of Evaluating Swine Feed Additives: Phytase And Alternatives To Antibiotic Growth Promoters, Kristin Olsen

Graduate Theses and Dissertations

Feed additives are often included in swine diets to increase digestibility of certain nutrients, improve intestinal function, and prevent or mitigate illness, ultimately with a goal of improved productivity. Whenever additives are introduced into diets, it is imperative that their efficacy be demonstrated with thorough research, and the elucidation of information such as proper inclusion rate and effects on the pig is necessary for their inclusion to be practical and economically favorable. Thus, proper evaluation of feed additives is critical. The objective of this thesis was to investigate the methods with which phytase and alternatives to antibiotic growth promoters (AGP ...


Development Of A Novel Anti-Infectivity Platform For The Treatment Of Neglected Tropical And Infectious Diseases, Andrea Marie Binnebose Jan 2018

Development Of A Novel Anti-Infectivity Platform For The Treatment Of Neglected Tropical And Infectious Diseases, Andrea Marie Binnebose

Graduate Theses and Dissertations

This dissertation focuses on the design of novel strategies for the prevention and treatment of neglected tropical and infectious diseases using polyanhydride nanoparticles as a drug delivery platform. The overall goal of this research is to design efficacious drug delivery vehicles that are effective against the filarial nematode Brugia malayi and B. pahangi and intracellular bacteria Mycobacterium tuberculosis, M. paratuberculosis, and M. marinum. The primary goal is to use the polyanhydride nanoparticles to deliver high enough microenvironmental concentrations to cause the death of the organism, thereby reducing the mortality, morbidity, and transmission of the disease. While a wide array of ...


Infiltrating The Hive Mind: Immune And Viral Effects On Behavior Of The Honey Bee (Apis Mellifera), Amy C. Geffre Jan 2018

Infiltrating The Hive Mind: Immune And Viral Effects On Behavior Of The Honey Bee (Apis Mellifera), Amy C. Geffre

Graduate Theses and Dissertations

Pathogens are important to the ecology of all organisms. This thesis describes host-pathogen interactions between Apis mellifera and Israeli acute paralysis virus (Dicistroviridae). Viral pathogens are critical factors in honey bee health, but effects of viral infection on honey bee behavior are difficult to study and can manifest differently across contexts. Collectively, this work seeks to better describe these host-pathogen interactions between honey bees and their viruses.

Firstly, we fed bees with viral sequence-based dsRNA, as a sham-virus to elicit RNA interference-based anti-viral immune response. We paired these bees with untreated bees and observed their interactions. Notably, we found that ...