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2006

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Full-Text Articles in Life Sciences

Lake Mead National Recreation Area Vegetation Monitoring And Management: Quarterly Progress Report, Period Ending December 31, 2006, Margaret N. Rees Dec 2006

Lake Mead National Recreation Area Vegetation Monitoring And Management: Quarterly Progress Report, Period Ending December 31, 2006, Margaret N. Rees

Vegetation Monitoring

Executive Summary

  • Two new Weed Sentry research assistants were hired.
  • Weed Sentry staff surveyed for exotic species on 89 miles of roads on NPS and BLM land and treated more than 21,000 exotic plants in incipient populations.
  • A grid-based rare plant monitoring method was tested this quarter.
  • A manuscript detailing vegetation succession on a water pipeline at Lake Mead NRA was submitted for review to the journal Crossosoma.
  • New integrative projects undertaken this quarter included establishing a competition study between a native grass and the exotic Sahara mustard, salvaging plants for research purposes from private sites with permission from ...


Oliver Ranch Science School Complex & Wild Horse And Burro Facility: Final Close-Out Report, Margaret N. Rees Dec 2006

Oliver Ranch Science School Complex & Wild Horse And Burro Facility: Final Close-Out Report, Margaret N. Rees

Oliver Ranch Project

“The mission of the Red Rock Desert Learning Center is to instill stewardship and respect by increasing knowledge and understanding of the Mojave Desert ecosystems and cultures through a unique experiential discovery program.”


Juvenile Soft-Shell Clam, Mya Arenaria L.Research In The Hampton-Seabrook Estuary, Brian F. Beal Dec 2006

Juvenile Soft-Shell Clam, Mya Arenaria L.Research In The Hampton-Seabrook Estuary, Brian F. Beal

PREP Reports & Publications

A series of field experiments was conducted at two intertidal sites in the Hampton Seabrook Estuary from November 2004-2006 to assess the efficacy of enhancing intertidal areas with cultured clam (Mya arenaria L.) seed (mean shell length [SL] = 7-10 mm). Measurement variables in each experiment included survival and growth of both cultured and wild seed clams. The first of three trials (November 2004 - May 2005) examined the interactive effects of size of planting area (4 m2, 8 m2, 12 m2, and 18 m2) and predator deterrent netting (none, 4.2 mm, and 6.4 mm aperture [flexible, plastic netting]) at ...


Lake Mead National Recreation Area Monitoring And Evaluation Of Sensitive Wildlife: Quarterly Progress Report, Period Ending December 31, 2006, Margaret N. Rees Dec 2006

Lake Mead National Recreation Area Monitoring And Evaluation Of Sensitive Wildlife: Quarterly Progress Report, Period Ending December 31, 2006, Margaret N. Rees

Wildlife Monitoring

  • Research assistant hired for Relict Leopard Frog conservation project.
  • High school minority intern hired to assist with research efforts.
  • Nocturnal visual encounter surveys for Relict Leopard Frogs conducted at all established natural sites and at 6 of 7 translocation sites.
  • Vegetation management conducted to decrease tamarisk cover along the stream at the Pupfish Refuge Spring – a Relict Leopard Frog translocation site.
  • New draft guidelines and field count protocols developed for midwinter bald eagle count.
  • Preliminary analysis and modeling of thrasher habitat selection conducted and sampling assessed
  • Call-broadcast surveys for thrasher species conducted at 43 points countywide, focusing on vegetation assemblages ...


Nroc Coordination And Program Delivery, Amanda Stone, Frank Mitchell Dec 2006

Nroc Coordination And Program Delivery, Amanda Stone, Frank Mitchell

PREP Reports & Publications

The primary goal of the Natural Resources Outreach Coalition (NROC) program is to provide education and outreach to communities in the NH Coastal Watersheds that are dealing with the effects of growth, and looking for ways to conserve open spaces and natural resources. Program objectives to meet this goal include: 1. NROC and client communities determine natural resource concerns of the communities. 2. NROC and client communities gather community information about these concerns 3. NROC develops and client communities host community presentations about natural resource-based planning. 4. Communities receive follow up technical and educational assistance as requested. In 2006, NROC ...


Shellfish Tissue Monitoring In New Hampshire Estuaries 2005, Phil Trowbridge Dec 2006

Shellfish Tissue Monitoring In New Hampshire Estuaries 2005, Phil Trowbridge

PREP Reports & Publications

Conducted by a committee of Canadian and US government and university scientists, Gulfwatch examines the effects of decades of development and industrialization on the water quality of the Gulf as it relates to human health as well as its impact on other marine organisms. Gulfwatch scientists collect blue mussels at over 60 US and Canadian sites Gulf-wide, and analyze the organisms’ tissue for potentially harmful levels and concentrations of toxins including heavy metals, chlorinated pesticides, polychlorinated biphenyls (PCBs), and polycyclic aromatic hydrocarbons (PAHs). New Hampshire increased the number of Gulfwatch sampling locations from two sites per year in 1997 to ...


Shoreland Buffer Module For Granit Data Mapper, Fay A. Rubin, David G. Justice Dec 2006

Shoreland Buffer Module For Granit Data Mapper, Fay A. Rubin, David G. Justice

PREP Reports & Publications

The Complex Systems Research Center at the University of New Hampshire enhanced the GRANIT Data Mapper (http://mapper.granit.unh.edu) by incorporating data describing shoreline buffers in New Hampshire. The project supports an ongoing, comprehensive New Hampshire Estuaries Project (NHEP) outreach initiative that seeks to educate municipal decision-makers about the importance of stream buffers in preserving water quality in coastal New Hampshire. It complements these existing outreach efforts by allowing coastal managers, local land use boards, and the general public to readily visualize the spatial extent of current and/or proposed shoreline regulations in their community. The primary data ...


Town Of Strafford Nroc Projects, Carolyn Page, Al Pratt, Jeff Schloss, Harmony Anderson Dec 2006

Town Of Strafford Nroc Projects, Carolyn Page, Al Pratt, Jeff Schloss, Harmony Anderson

PREP Reports & Publications

The three Strafford committees formed through the work with the Natural Resources Outreach Coalition in 2004 and supported by the grant award from the New Hampshire Estuaries Project have succeeded in furthering land protection, water quality protection, and managing growth here in Strafford. The original NROC meetings brought many new volunteer citizens into the process, but even their enthusiasm and willingness to work could not have earned these results without the financial support of the NHEP grant award. Hours of letter writing and personal contact with landowners by the volunteers of the Land Protection Group have raised awareness of the ...


Cadmium Toxicity On Arterioles Vascular Smooth Muscle Cells Of Spontaneously Hypertensive Rats, Benny Washington, Shunta Williams, Patrice Armstrong, Charlie Mtshali, John T. Robinson, Elbert L. Myles Dec 2006

Cadmium Toxicity On Arterioles Vascular Smooth Muscle Cells Of Spontaneously Hypertensive Rats, Benny Washington, Shunta Williams, Patrice Armstrong, Charlie Mtshali, John T. Robinson, Elbert L. Myles

Biology Faculty Research

Cadmium (Cd) is frequently used in various industrial applications and is a ubiquitous environmental toxicant, also present in tobacco smoke. An important route of exposure is the circulatory system whereas blood vessels are considered to be main stream organs of Cd toxicity. Our previous results indicate that cadmium chloride (CdCl2) affects mean arterial blood pressure in hypertensive rats. We hypothesized that Cd alters the intracellular calcium transient mechanism, by cadmium-induced stimulation of MAPKs (ERK 1 & 2) which is mediated partially through calcium-dependent PKC mechanism. To investigate this hypothesis, we exposed primary cultures of vascular smooth muscle cells (VSMCs) from wistar ...


Recent Advances In Basic Neurosciences And Brain Disease: From Synapses To Behavior, Guo-Qiang Bi, Vadim Bolshakov, Guojun Bu, Catherine M. Cahill, Zhou-Feng Chen, Graham L. Collingridge, Robin L. Cooper, Jens R. Coorssen, Alaa El-Husseini, Vasco Galhardo, Wen-Biao Gan, Jianguo Gu, Kazuhide Inoue, John Isaac, Koichi Iwata, Zhengping Jia, Bong-Kiun Kaang, Mikito Kawamata, Satoshi Kida, Eric Klann, Tatsuro Kohno, Min Li, Xiao-Jiang Li, John F. Macdonald, Karim Nader, Peter V. Nguyen, Uhtaek Oh, Ke Ren, John C. Roder, Michael W. Salter, Weihong Song, Shuzo Sugita, Shao-Jun Tang, Yuanxiang Tao, Yu Tian Wang, Newton Woo, Melanie A. Woodin, Zhen Yan, Megumu Yoshimura, Ming Xu, Zao C. Xu, Xia Zhang, Mei Zhen, Min Zhuo Dec 2006

Recent Advances In Basic Neurosciences And Brain Disease: From Synapses To Behavior, Guo-Qiang Bi, Vadim Bolshakov, Guojun Bu, Catherine M. Cahill, Zhou-Feng Chen, Graham L. Collingridge, Robin L. Cooper, Jens R. Coorssen, Alaa El-Husseini, Vasco Galhardo, Wen-Biao Gan, Jianguo Gu, Kazuhide Inoue, John Isaac, Koichi Iwata, Zhengping Jia, Bong-Kiun Kaang, Mikito Kawamata, Satoshi Kida, Eric Klann, Tatsuro Kohno, Min Li, Xiao-Jiang Li, John F. Macdonald, Karim Nader, Peter V. Nguyen, Uhtaek Oh, Ke Ren, John C. Roder, Michael W. Salter, Weihong Song, Shuzo Sugita, Shao-Jun Tang, Yuanxiang Tao, Yu Tian Wang, Newton Woo, Melanie A. Woodin, Zhen Yan, Megumu Yoshimura, Ming Xu, Zao C. Xu, Xia Zhang, Mei Zhen, Min Zhuo

Biology Faculty Publications

Understanding basic neuronal mechanisms hold the hope for future treatment of brain disease. The 1st international conference on synapse, memory, drug addiction and pain was held in beautiful downtown Toronto, Canada on August 21-23, 2006. Unlike other traditional conferences, this new meeting focused on three major aims: (1) to promote new and cutting edge research in neuroscience; (2) to encourage international information exchange and scientific collaborations; and (3) to provide a platform for active scientists to discuss new findings. Up to 64 investigators presented their recent discoveries, from basic synaptic mechanisms to genes related to human brain disease. This meeting ...


Switchgrass For Biomass Feedstock In The Usa, Matt Sanderson, Paul Adler, Akwasi Boateng, Michael Casler, Gautam Sarath Dec 2006

Switchgrass For Biomass Feedstock In The Usa, Matt Sanderson, Paul Adler, Akwasi Boateng, Michael Casler, Gautam Sarath

Publications from USDA-ARS / UNL Faculty

Switchgrass has received much study for biomass feedstock production and conversion through research funded by the US-DOE and USDA during the past two decades. We have an improved understanding of the adaptation of existing cultivars and new cultivars with yield and adaptation improvements are now appearing. We also have a good understanding of the agronomics of switchgrass production, mainly from its use as a forage crop. There remain several constraints to switchgrass use in bioenergy cropping systems, including reliable establishment methods to obtain productive stands in the first year, targeted fertilization and nutrient management techniques to efficiently use nitrogen fertilizer ...


Information And Data Management Program's Pi Workshop, Peggy Agouris Dec 2006

Information And Data Management Program's Pi Workshop, Peggy Agouris

University of Maine Office of Research Administration: Grant Reports

The objective of this workshop is to bring together the PIs and Co-PIs currently funded by the Information and Data Management Program of the National Science Foundation to discuss and exchange ideas on the focus topics of their field, as well as to identify and elaborate on emerging themes and particular emphases for future activities.

More specifically, the researchers, along with selected industry and government invitees, cooperatively focused on:

(1) analyzing research and development issues fundamental in making progress towards new challenges imposed by such diverse data sources as the Internet, embedded and distributed sensors, and satellites;

(2) specifying areas ...


Information And Data Management Program's Pi Workshop, Peggy Agouris Dec 2006

Information And Data Management Program's Pi Workshop, Peggy Agouris

University of Maine Office of Research Administration: Grant Reports

The objective of this workshop is to bring together the PIs and Co-PIs currently funded by the Information and Data Management Program of the National Science Foundation to discuss and exchange ideas on the focus topics of their field, as well as to identify and elaborate on emerging themes and particular emphases for future activities.

More specifically, the researchers, along with selected industry and government invitees, cooperatively focused on:

(1) analyzing research and development issues fundamental in making progress towards new challenges imposed by such diverse data sources as the Internet, embedded and distributed sensors, and satellites;

(2) specifying areas ...


Cains Brook And Mill Creek Watershed Management Plan, Town Of Seabrook, Waterfront Engineers, Inc. Dec 2006

Cains Brook And Mill Creek Watershed Management Plan, Town Of Seabrook, Waterfront Engineers, Inc.

PREP Reports & Publications

Cains Brook is a freshwater stream that flows in an easterly direction from its origin—a spring fed pond about one mile west of I-95 on the Salisbury, Massachusetts/Seabrook, New Hampshire border. At its lower reaches the brook is joined by Shepard Brook where it becomes Mill Creek, a tidal creek that discharges into the Hampton-Seabrook estuary. Along its course there are several ponds on either side of US Route 1—Secords, Cains and Mary’s Ponds to the west of Route 1 and Cains Mill Pond and Noyes Pond to the east. This stream system is approximately 3 ...


Land Conservation Plan For New Hampshire’S Coastal Watersheds – Implementation & Outreach, Mark Zankel Dec 2006

Land Conservation Plan For New Hampshire’S Coastal Watersheds – Implementation & Outreach, Mark Zankel

PREP Reports & Publications

The Nature Conservancy was awarded funding to complete activities to promote the Land Conservation Plan for New Hampshire’s Coastal Watersheds in the fall of 2006. The Nature Conservancy and its partners, Society for the Protection of New Hampshire Forests, Rockingham Planning Commission, and Strafford Regional Planning Commission, conducted the following tasks to increase understanding and use of the plan by communities, land trusts and others interested in land protection.


Properties Of Corneal Receptors In A Teleost Fish, Paul J. Ashley, Lynne U. Sneddon, Catherine R. Mccrohan Dec 2006

Properties Of Corneal Receptors In A Teleost Fish, Paul J. Ashley, Lynne U. Sneddon, Catherine R. Mccrohan

Veterinary Science and Medicine Collection

Corneal receptors have not previously been identified in lower vertebrates. The present study describes the properties of trigeminal ganglion corneal receptors in a teleost fish, the rainbow trout (Oncoryhnchus mykiss). Out of 27 receptors, 7 were polymodal nociceptors, 6 were mechanothermal nociceptors, 2 were mechanochemical receptors and the largest group, 12, were only responsive to mechanical stimulation. No cold responsive receptors were found on the trout cornea. Mechanical and thermal thresholds were lower and receptive field diameters smaller than those of cutaneous trigeminal receptors in the trout, demonstrating greater sensitivity in the cornea. The lack of cold sensitive neurons may ...


Recombinant Watermelon (Citrullus Lanatus) Hydroperoxide Lyase And Uses Thereof, David Hildebrand, Hirotada Fukushige Dec 2006

Recombinant Watermelon (Citrullus Lanatus) Hydroperoxide Lyase And Uses Thereof, David Hildebrand, Hirotada Fukushige

Plant and Soil Sciences Faculty Patents

Recombinant watermelon (Citrullus lanatus) hydroperoxide lyase protein, DNA sequences encoding the protein, vectors containing the DNA sequences and hosts containing the vectors are provided, together with methods for recombinantly producing watermelon hydroperoxide lyase, DNA sequences, vectors and hosts.


Untemplated Oligoadenylation Promotes Degradation Of Risc-Cleaved Transcripts, Fadia Ibrahim, Jennifer Rohr, Won-Joong Jeong, Jennifer Hesson, Heriberto D. Cerutti Dec 2006

Untemplated Oligoadenylation Promotes Degradation Of Risc-Cleaved Transcripts, Fadia Ibrahim, Jennifer Rohr, Won-Joong Jeong, Jennifer Hesson, Heriberto D. Cerutti

Faculty Publications from the Center for Plant Science Innovation

In the best-characterized mechanism of RNAmediated silencing, small interfering RNAs (siRNAs), incorporated into the RNA-induced silencing complex (RISC), guide the endonucleolytic cleavage of complementary RNAs (1). In Drosophila melanogaster, these RISC-generated products are eventually degraded by exoribonucleases: Xrn1, a 5′-to-3′ exonuclease, and exosome, a 3′-to-5′ multisubunit exonuclease (2). Interestingly, in Arabidopsis thaliana and in mammals, an oligouridine or oligoadenine [oligo(U/A)] tail is added to the 5′ RNA fragments resulting from microRNA-directed cleavage (3). However, the biological role of this tail remains unclear.


The Plant Structure Ontology, A Unified Vocabulary Of Anatomy And Morphology Of A Flowering Plant, Katica Ilic, Elizabeth A. Kellogg, Pankaj Jaiswal, Felipe Zapata, Peter F. Stevens, Leszek P. Vincent, Shulamit Avraham, Leonore Reiser, Anuradha Pujar, Martin M. Sachs, Noah T. Whitman, Susan R. Mccouch, Mary L. Schaeffer, Doreen H. Ware, Lincoln D. Stein, Seung Y. Rhee Dec 2006

The Plant Structure Ontology, A Unified Vocabulary Of Anatomy And Morphology Of A Flowering Plant, Katica Ilic, Elizabeth A. Kellogg, Pankaj Jaiswal, Felipe Zapata, Peter F. Stevens, Leszek P. Vincent, Shulamit Avraham, Leonore Reiser, Anuradha Pujar, Martin M. Sachs, Noah T. Whitman, Susan R. Mccouch, Mary L. Schaeffer, Doreen H. Ware, Lincoln D. Stein, Seung Y. Rhee

Peter Stevens

Formal description of plant phenotypes and standardized annotation of gene expression and protein localization data require uniform terminology that accurately describes plant anatomy and morphology. This facilitates cross species comparative studies and quantitative comparison of phenotypes and expression patterns. A major drawback is variable terminology that is used to describe plant anatomy and morphology in publications and genomic databases for different species. The same terms are sometimes applied to different plant structures in different taxonomic groups. Conversely, similar structures are named by their species-specific terms. To address this problem, we created the Plant Structure Ontology (PSO), the first generic ontological ...


Activated Checkpoint Kinase 2 Provides A Survival Signal For Tumor Cells, Jagadish C. Ghosh, Takehiko Dohi, Christopher M. Raskett, Timothy F. Kowalik, Dario C. Altieri Dec 2006

Activated Checkpoint Kinase 2 Provides A Survival Signal For Tumor Cells, Jagadish C. Ghosh, Takehiko Dohi, Christopher M. Raskett, Timothy F. Kowalik, Dario C. Altieri

Open Access Publications by UMass Chan Authors

Tumor cells often become resistant to DNA damage-based therapy; however, the underlying mechanisms are not yet understood. Here, we show that tumor cells exposed to DNA damage counteract cell death by releasing the antiapoptotic protein, survivin, from mitochondria. This is independent of p53, and requires activated checkpoint kinase 2 (Chk2), a putative tumor suppressor. Molecular or genetic targeting of Chk2 prevents the release of survivin from mitochondria, enhances DNA damage-induced tumor cell apoptosis, and inhibits the growth of resistant in vivo tumors. Therefore, activated Chk2 circumvents its own tumor-suppressive functions by promoting tumor cell survival. Inhibiting Chk2 in combination with ...


Spatial Variation In The Chemical Composition Of Natal Otholiths From A Reef Fish In The Galápagos Islands, Benjamin I. Ruttenberg, Robert R. Warner Dec 2006

Spatial Variation In The Chemical Composition Of Natal Otholiths From A Reef Fish In The Galápagos Islands, Benjamin I. Ruttenberg, Robert R. Warner

Biological Sciences

Over the past decade, researchers have used variation in the chemical composition of fish otoliths (earstones) to address a number of ecological questions, such as stock assessment and assessing rates of movement of individuals among habitats or life-history stages. However, these methods have yet to be applied successfully to the study of larval connectivity, a major unanswered question in marine ecology. Accomplishing this task requires a reference collection of pre-pelagic natal otoliths and accurate measurement of the chemical signatures of otoliths cores of recruits. We analyzed the chemical composition of natal otoliths from near-term benthic eggs of a damselfish (Stegastes ...


The Health And Nutrition Of Migrant Farm Workers In South Carolina, Abel Caballero Dec 2006

The Health And Nutrition Of Migrant Farm Workers In South Carolina, Abel Caballero

All Theses

ABSTRACT
Migrant farm workers--a high percentage of which are Hispanic--are an extremely disadvantaged population that experiences several barriers, including language, nutrition, transportation, and access to health services. This population also suffers from numerous diseases (obesity, diabetes, and heart disease) and experiences various hazards associated with risky work, such as pesticide exposure. This study included data collection on basic health and nutrition barriers to identify areas where programs and policies can be modified to better serve migrant farm workers. In addition, data was examined to determine the effect of all-inclusive educational intervention on nutrition, dental, fitness, and food safety issues by ...


High Sensitivity Rna Pseudoknot Prediction, Xiaolu Huang, Hesham Ali Dec 2006

High Sensitivity Rna Pseudoknot Prediction, Xiaolu Huang, Hesham Ali

Information Systems and Quantitative Analysis Faculty Publications

Most ab initio pseudoknot predicting methods provide very few folding scenarios for a given RNA sequence and have low sensitivities. RNA researchers, in many cases, would rather sacrifice the specificity for a much higher sensitivity for pseudoknot detection. In this study, we introduce the Pseudoknot Local Motif Model and Dynamic Partner Sequence Stacking (PLMM_DPSS) algorithm which predicts all PLM model pseudoknots within an RNA sequence in a neighboring-region-interferencefree fashion. The PLM model is derived from the existing Pseudobase entries. The innovative DPSS approach calculates the optimally lowest stacking energy between two partner sequences. Combined with the Mfold, PLMM_DPSS can also ...


Aged Rats: Sex Differences And Responses To Chronic Stress, Rachel E. Bowman, Neil J. Maclusky, Samantha Diaz-Weinstein, Mark C. Zrull, Victoria N. Luine Dec 2006

Aged Rats: Sex Differences And Responses To Chronic Stress, Rachel E. Bowman, Neil J. Maclusky, Samantha Diaz-Weinstein, Mark C. Zrull, Victoria N. Luine

Psychology Faculty Publications

Cognitive, as well as physiological, sex differences exist in young adult rats under both basal conditions and following chronic stress; however, few studies have examined whether sex differences remain in aged subjects and whether responses to stress are altered. We compared aged male and female Fischer 344 rats (21.5 months at testing) without stress and when given 21 days of restraint for 6 h/day on locomotion, anxiety-related behaviors, object recognition (non-spatial memory), object placement (spatial memory), body weight and serum steroid hormone levels. Control (unstressed) females had lower levels of estradiol and testosterone and higher corticosterone than males ...


Caenorhabditis Briggsae Methods, Scott Everet Baird, Helen M. Chamberlin Dec 2006

Caenorhabditis Briggsae Methods, Scott Everet Baird, Helen M. Chamberlin

Biological Sciences Faculty Publications

Caenorhabditis briggsae is being developed in parallel to C. elegans as a model system, primarily for the study of evolution. Like C. elegans, C. briggsae is a protandrous hermaphrodite and like C. elegans, its genome has been sequenced. From this point, these two model systems diverge. The development, behavior, and physiology of C. elegans have been characterized through tens of thousands of genetic and molecular studies. Genetic and molecular characterizations of C. briggsae are relatively few. Experimental resources in C. elegans include a high density recombination map that is well integrated with the genome sequence. The C. briggsae recombination map ...


Computational Promoter Analysis Of Mouse, Rat, And Human Antimicrobial Peptide-Coding Genes, Chin-Yo Lin, Manisha Brahmachary, Christian Schonbach, Liang Yang, Enli Huang, Sin Lam Tan, Rajesh Chowdhary, S. P. T. Krishnan, David A. Hume, Chikatoshi Kai, Jun Kawai, Piero Carninci, Yoshihide Hayashizaki, Vladimir B. Bajic Dec 2006

Computational Promoter Analysis Of Mouse, Rat, And Human Antimicrobial Peptide-Coding Genes, Chin-Yo Lin, Manisha Brahmachary, Christian Schonbach, Liang Yang, Enli Huang, Sin Lam Tan, Rajesh Chowdhary, S. P. T. Krishnan, David A. Hume, Chikatoshi Kai, Jun Kawai, Piero Carninci, Yoshihide Hayashizaki, Vladimir B. Bajic

Faculty Publications

Mammalian antimicrobial peptides (AMPs) are effectors of the innate immune response. A multitude of signals coming from pathways of mammalian pathogen/pattern recognition receptors and other proteins affect the expression of AMP-coding genes (AMPcgs). For many AMPcgs the promoter elements and transcription factors that control their tissue cell-specific expression have yet to be fully identified and characterized. Results- Based upon the RIKEN full-length cDNA and public sequence data derived from human, mouse and rat, we identified 178 candidate AMP transcripts derived from 61 genes belonging to 29 AMP families. However, only for 31 mouse genes belonging to 22 AMP families ...


Modulating Role Of Rna Structure In Alternative Splicing Of A Critical Exon In The Spinal Muscular Atrophy Genes, Natalia N. Singh, Ravindra N. Singh, Elliot J. Androphy Dec 2006

Modulating Role Of Rna Structure In Alternative Splicing Of A Critical Exon In The Spinal Muscular Atrophy Genes, Natalia N. Singh, Ravindra N. Singh, Elliot J. Androphy

Open Access Publications by UMass Chan Authors

Humans have two nearly identical copies of the survival motor neuron (SMN ) gene, SMN1 and SMN2. Homozygous loss of SMN1 causes spinal muscular atrophy (SMA). SMN2 is unable to prevent the disease due to skipping of exon 7. Using a systematic approach of in vivo selection, we have previously demonstrated that a weak 5' splice site (ss) serves as the major cause of skipping of SMN2 exon 7. Here we show the inhibitory impact of RNA structure on the weak 5' ss of exon 7. We call this structure terminal stem-loop 2 (TSL2). Confirming the inhibitory nature of TSL2, point ...


West River Ag Center Crops And Soils Research Annual Progress Report, 2006, Agricultural Experiment Station Dec 2006

West River Ag Center Crops And Soils Research Annual Progress Report, 2006, Agricultural Experiment Station

Agricultural Experiment Station and Research Farm Annual Reports

This is the 2006 progress report of the West River Crops and Soils Research Projects, South Dakota Agricultural Experiment Station. This document includes reports on: weather and climate, wheat and grain variety trials, management and tillage, and weed and pest control.


Central Crops And Soils Research Station Highmore, South Dakota: Annual Progress Report, 2006, Agricultural Experiment Station, Plant Science Department Dec 2006

Central Crops And Soils Research Station Highmore, South Dakota: Annual Progress Report, 2006, Agricultural Experiment Station, Plant Science Department

Agricultural Experiment Station and Research Farm Annual Reports

This is the 2006 progress report for the Central Crops and Soils Research Station at Highmore, South Dakota State College. This document represents the research conducted at the Station during the 2006 crop season including: temperature and precipitation data, evaluation of native and naturalized grasses for reduced-input turf in the Northern Plains, 2006 NTEP tall fescue ancillary trial for drought tolerance, field evaluations of woody plant materials, alfalfa production, optimal management of drought -tolerant legumes and warm season annual grasses, winter wheat breeding, evaluation of sunflower germplasm for resistance to the red sunflower seed weevil, weed control, fertilizer influence on ...


Structure Of The Yeast Histone H3-Asf1 Interaction: Implications For Chaperone Mechanism, Species-Specific Interactions, And Epigenetics, Andrew J. Antczak, Toshiaki Tsubota, Paul D. Kaufman, James M. Berger Dec 2006

Structure Of The Yeast Histone H3-Asf1 Interaction: Implications For Chaperone Mechanism, Species-Specific Interactions, And Epigenetics, Andrew J. Antczak, Toshiaki Tsubota, Paul D. Kaufman, James M. Berger

Program in Gene Function and Expression Publications

BACKGROUND: The histone H3/H4 chaperone Asf1 (anti-silencing function 1) is required for the establishment and maintenance of proper chromatin structure, as well as for genome stability in eukaryotes. Asf1 participates in both DNA replication-coupled (RC) and replication-independent (RI) histone deposition reactions in vitro and interacts with complexes responsible for both pathways in vivo. Asf1 is known to directly bind histone H3, however, high-resolution structural information about the geometry of this interaction was previously unknown. RESULTS: Here we report the structure of a histone/histone chaperone interaction. We have solved the 2.2 A crystal structure of the conserved N-terminal ...