Life Sciences Commons^™

Tackling New Federal Agency Public Access Mandates At The University Of Arizona, Ahlam A. Saleh, Christine Kollen, Dan Lee, Scott Pryor, Lori Schultz

University of Massachusetts and New England Area Librarian e-Science Symposium

Objective: In 2014, federal agencies began releasing their implementation plans in response to the 2013 White House’s Office of Science and Technology Policy (OSTP) Increasing Access to the Results of Federally Funded Research policy memorandum. The University has in place an established Data Management support service, which has addressed new data requirements. However, in early 2016 the University of Arizona Libraries (UAL) and Office of Research, Discovery & Innovation (RDI) convened to discuss how the university can help researchers address these new growing federal agency mandates on manuscripts and data.

Methods: By the summer of 2016, a collaboration of UA ...

Atlanta University Center Faculty Publications: A Selective Bibliography, Robert W. Woodruff Library

Atlanta University Center Faculty Scholarship Bibliographies

On February 28, 2006, the Robert W. Woodruff Library and the Library Advisory Council hosted an exhibit and reception to celebrate the scholarly publications of Atlanta University Center faculty. As a complement to that event, the Robert W. Woodruff Library developed the publication, Atlanta University Center Faculty Publications: A Brief Bibliography, which highlights selected scholarly and research contributions of the Atlanta University Center faculty.

The bibliography illustrates the richness of faculty contributions within each institution and across the Atlanta University Center community. The celebration has become an annual event and this compilation represents the next phase of a living document ...

Data Publication With The Structural Biology Data Grid Supports Live Analysis, Peter A. Meyer, Stephanie Socias, Jason Key, Elizabeth Ransey, Emily C. Tjon, Alejandro Buschiazzo, Ming Lei, Chris Botka, James Withrow, David Neau, Kanagalaghatta Rajashankar, Karen S. Anderson, Richard H. Baxter, Stephen C. Blacklow, Titus J. Boggon, Alexandre M. J. J. Bonvin, Dominika Borek, Tom J. Brett, Amedeo Caflisch, Chung-I Chang, Walter J. Chazin, Kevin D. Corbett, Michael S. Cosgrove, Sean Crosson, Sirano Dhe-Paganon, Enrico Di Cera, Catherine L. Drennan, Michael J. Eck, Brandt F. Eichman, Qing R. Fan, Oleg V. Tsodikov

Pharmaceutical Sciences Faculty Publications

Access to experimental X-ray diffraction image data is fundamental for validation and reproduction of macromolecular models and indispensable for development of structural biology processing methods. Here, we established a diffraction data publication and dissemination system, Structural Biology Data Grid (SBDG; data.sbgrid.org), to preserve primary experimental data sets that support scientific publications. Data sets are accessible to researchers through a community driven data grid, which facilitates global data access. Our analysis of a pilot collection of crystallographic data sets demonstrates that the information archived by SBDG is sufficient to reprocess data to statistics that meet or exceed the quality ...

Atlanta University Center Faculty Publications: A Selective Bibliography, Robert W. Woodruff Library

Atlanta University Center Faculty Scholarship Bibliographies

On February 28, 2006, the Robert W. Woodruff Library and the Library Advisory Council hosted an exhibit and reception to celebrate the scholarly publications of Atlanta University Center faculty. As a complement to that event, the Robert W. Woodruff Library developed the publication, Atlanta University Center Faculty Publications: A Brief Bibliography, which highlights selected scholarly and research contributions of the Atlanta University Center faculty.

The bibliography illustrates the richness of faculty contributions within each institution and across the Atlanta University Center community. The celebration has become an annual event and this compilation represents the next phase of a living document ...

Characterization Of Antimicrobial Susceptibility Profile Of Biofield Treated Multidrug-Resistant Klebsiella Oxytoca, Mahendra Kumar Trivedi, Alice Branton, Dahryn Trivedi, Gopal Nayak, Harish Shettigar, Mayank Gangwar, Snehasis Jana

Mahendra Kumar Trivedi

Innate And Learned Preferences For Sweet Taste During Childhood, Alison K. Ventura, Julie A. Mennella

Alison K Ventura

Purpose of review: In nature, carbohydrates are a source of energy often equated with sweetness, the detection of which is associated with powerful hedonic appeal. Intakes of processed carbohydrates in the form of added sugars and sugar-sweetened beverages have risen consistently among all age groups over the last two decades. In this review, we describe the biological underpinnings that drive the consumption of sweet-tasting foods among pediatric populations. Recent findings: Scientific literature suggests that children's liking for all that is sweet is not solely a product of modern-day technology and advertising but reflects their basic biology. In fact, heightened ...

Bcl-2 Family Protein, Bad Is Down-Regulated In Breast Cancer And Inhibits Cell Invasion., Maria Cekanova, R Fernando, N Siriwardhana, M Sukthankar, Cde Parra, J Woraratphoka, C Malone, A Strom, Seung Baek, P Wade, A Saxton, Robert Donnell, R Pestell, S Dharmawardhane, J Wimalasena

Seung J Baek

We have previously demonstrated that the anti-apoptotic protein BAD is expressed in normal human breast tissue and shown that BAD inhibits expression of cyclin D1 to delay cell-cycle progression in breast cancer cells. Herein, expression of proteins in breast tissues was studied by immunohistochemistry and results were analyzed statistically to obtain semi-quantitative data. Biochemical and functional changes in BAD-overexpressing MCF7 breast cancer cells were evaluated using PCR, reporter assays, western blotting, ELISA and extracellular matrix invasion assays. Compared to normal tissues, Grade II breast cancers expressed low total/phosphorylated forms of BAD in both cytoplasmic and nuclear compartments. BAD overexpression ...

Bcl-2 Family Protein, Bad Is Down-Regulated In Breast Cancer And Inhibits Cell Invasion., Maria Cekanova, R Fernando, N Siriwardhana, M Sukthankar, Cde Parra, J Woraratphoka, C Malone, A Strom, Seung Baek, P Wade, A Saxton, Robert Donnell, R Pestell, S Dharmawardhane, J Wimalasena

Maria Cekanova MS, RNDr, PhD

We have previously demonstrated that the anti-apoptotic protein BAD is expressed in normal human breast tissue and shown that BAD inhibits expression of cyclin D1 to delay cell-cycle progression in breast cancer cells. Herein, expression of proteins in breast tissues was studied by immunohistochemistry and results were analyzed statistically to obtain semi-quantitative data. Biochemical and functional changes in BAD-overexpressing MCF7 breast cancer cells were evaluated using PCR, reporter assays, western blotting, ELISA and extracellular matrix invasion assays. Compared to normal tissues, Grade II breast cancers expressed low total/phosphorylated forms of BAD in both cytoplasmic and nuclear compartments. BAD overexpression ...

Chronic Exposure To Combined Carcinogens Enhances Breast Cell Carcinogenesis With Mesenchymal And Stem-Like Cell Properties., Lenora Pluchino, Hwa-Chain Wang

Lenora A. Pluchino, Ph.D.

Breast cancer is the most common type of cancer affecting women in North America and Europe. More than 85% of breast cancers are sporadic and attributable to long-term exposure to small quantities of multiple carcinogens. To understand how multiple carcinogens act together to induce cellular carcinogenesis, we studied the activity of environmental carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and benzo[a]pyrene (B[a]P), and dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) using our breast cell carcinogenesis model. Our study revealed, for the first time, that combined NNK and B[a]P enhanced breast cell carcinogenesis chronically induced ...

List Of Economics Department Pamphlets, Penny Stover

Economics Pamphlet Series

No abstract provided.

Developmental Ethanol Exposure Leads To Dysregulation Of Lipid Metabolism And Oxidative Stress In Drosophila, Theresa Logan-Garbisch, Anthony Bortolazzo, Peter Luu, Audrey Ford, David Do, Payam Khodabakhshi, Rachael L. French

Rachael L. French

Reactive Oxygen Species-Mediated Breast Cell Carcinogenesis Enhanced By Multiple Carcinogens And Intervened By Dietary Ergosterol And Mimosine, Lenora Pluchino, Amethyst Liu, Hwa-Chain Robert Wang

Lenora A. Pluchino, Ph.D.

Most breast cancers occur sporadically due to long-term exposure to low-dose carcinogens in the diet and the environment. Specifically, smoke, polluted air, and high temperature-cooked meats comprise multiple carcinogens, such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), benzo[α]pyrene (B[α]P), and 2-amino-1-methyl-6-phenylimidazo[4,5–b]pyridine (PhIP). We sought to determine if these carcinogens act together to induce breast cell carcinogenesis, and if so, whether non-cytotoxic dietary agents could intervene. We demonstrated that co-exposure to physiologically-achievable doses of NNK, B[α]P, and PhIP (NBP) holistically enhanced initiation and progression of breast cell carcinogenesis. Reactive oxygen species ...

Marine Protected Areas And Resilience To Sedimentation In The Solomon Islands, B. S. Halpern, K. A. Selkoe, Crow White, S. Albert, S. Aswani, M. Lauer

Crow White

The ability of marine protected areas (MPAs) to provide protection from indirect stressors, via increased resilience afforded by decreased impact from direct stressors, remains an important and unresolved question about the role MPAs can play in broader conservation and resource management goals. Over a five-year period, we evaluated coral and fish community responses inside and outside three MPAs within the Roviana Lagoon system in Solomon Islands, where sedimentation pressure from upland logging is substantial. We found little evidence that MPAs decrease impact or improve conditions and instead found some potential declines in fish abundance. We also documented modest to high ...

Evaluating Tradeoffs Among Ecosystem Services To Inform Marine Spatial Planning, Sarah E. Lester, Christopher Costello, Benjamin S. Halpern, Steven D. Gaines, Crow White, John A. Barth

Crow White

A central challenge for natural resource management is developing rigorous yet practical approaches for balancing the costs and benefits of diverse human uses of ecosystems. Economic theory has a long history of evaluating tradeoffs in returns from different assets to identify optimal investment strategies. There has been recent progress applying this framework to the delivery of ecosystem services in land use planning. However, despite growing national and international interest in marine spatial planning, there is a lack of parallel frameworks in the marine realm. This paper reviews an ecosystem service tradeoff analysis framework and provides a more comprehensive synthesis for ...

Phylogeography Of The California Sheephead, Semicossyphus Pulcher: The Role Of Deep Reefs As Stepping Stones And Pathways To Antitropicality, Marloes Poortvliet, Gary C. Longo, Kimberly Selkoe, Paul H. Berber, Crow White, Jennifer E. Caselle, Alejandro Perez-Matus, Steven D. Gaines, Giacomo Bernardi

Crow White

In the past decade, the study of dispersal of marine organisms has shifted from focusing predominantly on the larval stage to a recent interest in adult movement. Antitropical distributions provide a unique system to assess vagility and dispersal. In this study, we have focused on an antitropical wrasse genus, Semicossyphus, which includes the California sheephead, S. pulcher, and Darwin's sheephead, S. darwini. Using a phylogenetic approach based on mitochondrial and nuclear markers, and a population genetic approach based on mitochondrial control region sequences and 10 microsatellite loci, we compared the phylogenetic relationships of these two species, as well as ...

Engaging Youth In Lifelong Outdoor Adventure Activities Through A Nontraditional Public School Physical Education Program, Keri Schwab, Daniel L. Dustin

Keri Schwab

Engaging Youth in Lifelong Outdoor Adventure Activities through a Nontraditional Public School Physical Education Program

A Framework For Organizing Cancer-Related Variations From Existing Databases, Publications And Ngs Data Using A High-Performance Integrated Virtual Environment (Hive), Tsung-Jung Wu, Amirhossein Shamsaddini, Yang Pan, Krista Smith, Daniel J. Chrichton, Vahan Simonyan, Raja Mazumder

Biochemistry and Molecular Medicine Faculty Publications

Years of sequence feature curation by UniProtKB/Swiss-Prot, PIR-PSD, NCBI-CDD, RefSeq and other database biocurators has led to a rich repository of information on functional sites of genes and proteins. This information along with variation-related annotation can be used to scan human short sequence reads from next-generation sequencing (NGS) pipelines for presence of non-synonymous single-nucleotide variations (nsSNVs) that affect functional sites. This and similar workflows are becoming more important because thousands of NGS data sets are being made available through projects such as The Cancer Genome Atlas (TCGA), and researchers want to evaluate their biomarkers in genomic data. BioMuta, an ...

Tsu Faculty Publication Database, David Owerbach

David Owerbach

THE TSU faculty publication database is for the years 2012-2014. The database was constructed by the Office of Research and was last updated on November 20, 2014.

A Small Subset Of Fruitless Subesophageal Neurons Modulate Early Courtship In Drosophila, David H. Tran, Geoffrey W. Meissner, Rachael L. French, Bruce S. Baker

Rachael L. French

Food Choices For The 21st Century, Louise Berner, Nancy Childs, Constance Geiger, Carl Keen, Janet King, Janet Mcdonald, Sanford Miller, Suzanne Murphy, Harold Schmitz, Anne Shaw, Phil Tong, Connie Weaver

Phillip S. Tong

In December 1997, a coalition of health professional with a wide range of expertise in science, government, education, marketing and communications, convened to discuss the challenges and implications of food choices for the 21st Century. Taking the newly published Dietary Reference Intakes (DRIs) as a framework and starting point, the members of the coalition explored how health professionals can individualize dietary recommendation to help guide people in their food choices.

Longitudinal Transcriptomic Dysregulation In The Peripheral Blood Of Transgenic Huntington’S Disease Monkeys, Jannet Kocerha, Yuhong Liu, David Willoughby, Kumaravel Chidamparam, Joseph Benito, Kate Nelson, Yan Xu, Tim Chi, Heidi Engelhardt, Sean Moran, Shang-Hsun Yang, Shi-Hua Li, Xiao-Jiang Li, Katherine Larkin, Adam Neumann, Heather Banta, Jinjing Yang, Anthony W. S. Chan

Jannet Kocerha

Background: Huntington’s Disease (HD) is a progressive neurodegenerative disorder caused by an expansion in the polyglutamine (polyQ) region of the Huntingtin (HTT) gene. The clinical features of HD are characterized by cognitive, psychological, and motor deficits. Molecular instability, a core component in neurological disease progression, can be comprehensively evaluated through longitudinal transcriptomic profiling. Development of animal models amenable to longitudinal examination enables distinct disease-associated mechanisms to be identified.

Results: Here we report the first longitudinal study of transgenic monkeys with genomic integration of various lengths of the human HTT gene and a range of polyQ repeats. With this unique ...

Socialization Of Prospective Physical Education Teachers: The Story Of New Blood, Camille P. O'Bryant, Mary O'Sullivan, Jeanne Raudensky

Camille O'Bryant

There has been much criticism of how teachers are prepared to teach and physical education has not been immune from this criticism. Despite numerous efforts to improve the content and focus of teacher education programmes there is still a paucity of programme evaluation research on the efficacy of these teacher education programmes (Metzler & Tjeerdsma, 1998). This paper reports on part of a yearlong investigation on the efficacy of a graduate physical education teacher education programme to prepare teachers. The focus of this aspect of the study was to identify what attracted graduate students to pursue a teaching career and what ...

Staying Alive: Maximizing Live Bacteria In Fermented Products, Phillip S. Tong

Phillip S. Tong

No abstract provided.

Phil Tong On Nutritious Frozen Dairy, Phillip S. Tong

Phillip S. Tong

No abstract provided.

Culturally Speaking: Beyond Yogurt, Phillip S. Tong

Phillip S. Tong

No abstract provided.

Culturally Speaking: The Year Of Sodium, Phillip S. Tong

Phillip S. Tong

No abstract provided.

Department Of Economics Publication List 2012, Penny Stover

Economics Pamphlet Series

This compilation lists works authored by Department of Economics faculty members and other staff working on projects funded through the Department of Economics. Publications resulting from their research and academic activities are indexed by author at the end of this pamphlet for easy access by the public. The articles were published between January 1, 2012 and December 31, 2012, except for those works printed in italics which have been accepted for publication but not actually printed as of December 31, 2012.

Meeting The Challenges: The Western Section's Role In Developing Tomorrow's Resource Management Professionals, John D. Perrine

John D. Perrine

The following is a slightly edited version of a plenary address delivered at the Western Section annual meeting in January 2009. The plenary theme was “The view from the future: wildlife management challenges and opportunities of the next 100 years.” Key references are listed at the end of the address. Readers will also be interested in the Winter 2009 (Vol. 3, No. 4) issue of The Wildlife Professional, which contains a special section on the preparation and training of future wildlife professionals.

A Novel Lux Operon In The Cryptically Bioluminescent Fish Pathogen Vibrio Salmonicida Is Associated With Virulence, Eric J. Nelson, Hege S. Tunsjø, Pat M. Fidopiastis, Henning Sørum, Edward G. Ruby

Pat Fidopiastis

The cold-water-fish pathogen Vibrio salmonicida expresses a functional bacterial luciferase but produces insufficient levels of its aliphatic-aldehyde substrate to be detectably luminous in culture. Our goals were to (i) better explain this cryptic bioluminescence phenotype through molecular characterization of the lux operon and (ii) test whether the bioluminescence gene cluster is associated with virulence. Cloning and sequencing of the V. salmonicida lux operon revealed that homologs of all of the genes required for luminescence are present: luxAB (luciferase) and luxCDE (aliphatic-aldehyde synthesis). The arrangement and sequence of these structural lux genes are conserved compared to those in related species of ...

North American Montane Red Foxes: Expansion, Fragmentation, And The Origin Of The Sacramento Valley Red Fox, Benjamin N. Sacks, Mark J. Statham, John D. Perrine, Samantha M. Wisely, Keith B. Aubry

John D. Perrine

Most native red foxes (Vulpes vulpes) in the western contiguous United States appear to be climatically restricted to colder regions in the major mountain ranges and, in some areas, have suffered precipitous declines in abundance that may be linked to warming trends. However, another population of unknown origin has occurred in arid habitats in the Sacramento Valley of California well outside this narrow bioclimatic niche since at least 1880. If native, this population would be ecologically distinct among indigenous North American red foxes. We used mitochondrial and microsatellite markers from historical and modern samples (modes: 1910–1930 and 2000–2008 ...