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Articles 1 - 30 of 1950

Full-Text Articles in Life Sciences

Breed(Ing) Narratives: Visualizing Values In Industrial Farming, Camille Bellet, Emily Morgan Jan 2022

Breed(Ing) Narratives: Visualizing Values In Industrial Farming, Camille Bellet, Emily Morgan

Animal Studies Journal

In this study, we consider how farmed animals, specifically pigs and chickens, are visualised in literature designed for circulation within animal production industries. The way breeding companies create and circulate images of industrial animals tells us a lot about their visions of what industrial animals are and how they believe animals should be treated. Drawing upon a wide range of material designed for circulation within animal production industries, from the 1880s to the 2010s, this paper examines how representations of pigs and chickens contribute to stories of perfection and advance ideals of power, race, gender, and progress. We demonstrate that …


Efficacy Of The Feline Temperament Profile In Evaluating Sheltered Cats For Adoption Into Families Of A Child With Autism Spectrum Disorder, Angélique Lamontagne, Rebecca A. Johnson, Gretchen K. Carlisle, Leslie A. Lyons, Jessica L. Bibbo, Colleen Koch, Steven J. Osterlind Jan 2020

Efficacy Of The Feline Temperament Profile In Evaluating Sheltered Cats For Adoption Into Families Of A Child With Autism Spectrum Disorder, Angélique Lamontagne, Rebecca A. Johnson, Gretchen K. Carlisle, Leslie A. Lyons, Jessica L. Bibbo, Colleen Koch, Steven J. Osterlind

Animal Studies Journal

This project was part of the Feline Friends Study, which matches shelter cats with families of children with Autism Spectrum Disorder (ASD) to study children’s social behaviour and cats’ stress. Cats were screened for calm temperament using the Feline Temperament Profile (FTP). The FTP consists of ten phases, with a list of ‘acceptable’ and ‘questionable’ behaviours under each phase. Our aim was to answer the following research questions: What items of the FTP best predict temperament in shelter cats? What are similarities and differences in temperament between cats who qualified or did not qualify for placement? Forty-four shelter cats were …


The Illegal Wildlife Trade: Through The Eyes Of A One-Year-Old Pangolin (Manis Javanica), Lelia Bridgeland-Stephens Jan 2020

The Illegal Wildlife Trade: Through The Eyes Of A One-Year-Old Pangolin (Manis Javanica), Lelia Bridgeland-Stephens

Animal Studies Journal

This paper explores the literature on the illegal wildlife trade (IWT) by following the journey of a single imagined Sunda pangolin (Manis javanica) through the entire trading process. Literature on IWT frequently refers to non-human animals in terms of collectives, species, or body parts, for example ‘tons of pangolin scales’, rather than as subjective individuals. In contrast, this paper centralizes the experiences of an individual pangolin by using a cross- disciplinary methodology, combining fact with a fictional narrative of subjective pangolin experience, in an empathetic and egomorphic process. The paper draws together known legislation, trade practices, and pangolin biology, structured …


The Change In Farming: A Review, Neil Sandell May 2015

The Change In Farming: A Review, Neil Sandell

RadioDoc Review

The protagonist of the CBC documentary, The Change in Farming, is an 89-year-old farmer, called Henry. We learn that his grandson, Adam, has been recording Henry’s reminiscences about farming as a way of preserving his family heritage. The program was produced in 1998 by Adam Goddard, a 25-year-old musician and composer, in collaboration with veteran CBC producer, Steve Wadhams.

Adam is more hunter-gather than farmer. He collects found sound, an artist alert to its musical possibilities. He is composing a work using Henry’s speech. We hear the elder’s reaction. And then, in an indispensable coda, the two of them …


Induced Pluripotent Stem Cells As Tools For Disease Modelling And Drug Discovery In Alzheimer's Disease, Lezanne Ooi, Kuldip Sidhu, Anne Poljak, Greg Sutherland, Michael D. O'Connor, Perminder Sachdev, Gerald Munch Jan 2013

Induced Pluripotent Stem Cells As Tools For Disease Modelling And Drug Discovery In Alzheimer's Disease, Lezanne Ooi, Kuldip Sidhu, Anne Poljak, Greg Sutherland, Michael D. O'Connor, Perminder Sachdev, Gerald Munch

Faculty of Science - Papers (Archive)

Alzheimer’s disease (AD) is a progressive neurodegenerative brain disorder that leads to a progressive decline in a person’s memory and ability to communicate and carry out daily activities. The brain pathology in AD is characterized by extensive neuronal loss, particularly of cholinergic neurons, intracellular neurofibrillary tangles composed of the tau protein (NFTs) and extracellular deposition of plaques composed of β-amyloid (Aβ), a cleavage product of the amyloid precursor protein (APP). These two insoluble protein aggregates are accompanied by a chronic inflammatory response and extensive oxidative damage. Whereas dys-regulation of APP expression or processing appears to be important for the familial, …


Ten Trenches: A Scienceart Collaboration, Timothy J. Cohen, Martin Cohen, Stephanie Kermode, Michael G. Leggett Jan 2013

Ten Trenches: A Scienceart Collaboration, Timothy J. Cohen, Martin Cohen, Stephanie Kermode, Michael G. Leggett

Faculty of Science - Papers (Archive)

Collaborative and cross-disciplinary research by a group of artists and scientists in an Australian rural setting generates data and ideas that form the basis of a wider understanding of the ramifications of global warming and cooling within the local, regional and national community. The work is viewed as an initial educational platform that will allow the public to see and understand the complexities of climate-based research.


Transmembrane Domain Nrg1 Mutant Mice Show Altered Susceptibility To The Neurobehavioural Actions Of Repeated Thc Exposure In Adolescence, Leonora E. Long, Rose Chesworth, Xu-Feng Huang, Iain S. Mcgregor, Jonathon C. Arnold, Tim Karl Jan 2013

Transmembrane Domain Nrg1 Mutant Mice Show Altered Susceptibility To The Neurobehavioural Actions Of Repeated Thc Exposure In Adolescence, Leonora E. Long, Rose Chesworth, Xu-Feng Huang, Iain S. Mcgregor, Jonathon C. Arnold, Tim Karl

Faculty of Health and Behavioural Sciences - Papers (Archive)

Heavy cannabis abuse increases the risk of developing schizophrenia. Adolescents appear particularly vulnerable to the development of psychosis-like symptoms after cannabis use. To test whether the schizophrenia candidate gene neuregulin 1 (NRG1) modulates the effects of cannabinoids in adolescence, we tested male adolescent heterozygous transmembrane domain Nrg1 mutant (Nrg1 TM HET) mice and wild type-like littermates (WT) for their neurobehavioural response to repeated Δ9-tetrahydrocannabinol (THC, 10 mg/kg i.p. for 21 d starting on post-natal day 31). During treatment and 48 h after treatment withdrawal, we assessed several behavioural parameters relevant to schizophrenia. After behavioural testing we measured autoradiographic …


Musculoskeletal And Estrogen Changes During The Adolescent Growth Spurt In Girls, Catherine Y. Wild, Julie R. Steele, Bridget J. Munro Jan 2013

Musculoskeletal And Estrogen Changes During The Adolescent Growth Spurt In Girls, Catherine Y. Wild, Julie R. Steele, Bridget J. Munro

Faculty of Health and Behavioural Sciences - Papers (Archive)

Introduction: The adolescent growth spurt is associated with rapid growth and hormonal changes, thought to contribute to the increased anterior cruciate ligament injury risk in girls. However, relatively little is known about these musculoskeletal and estrogen changes during the growth spurt in girls. Purpose: To investigate the longitudinal changes in estrogen as well as anterior knee laxity and lower limb strength and flexibility throughout the adolescent growth spurt in girls. Methods: Thirty-three healthy girls, age 10-13 yr, in Tanner stage II and 4-6 months from their peak height velocity were recruited. Participants were tested up to four times during the …


Direct Evidence For Encoding Of Motion Streaks In Human Visual Cortex, Deborah M. Apthorp, D. Samuel Schwarzkopf, C. Kaul, B. Bahrami, David Alais, G. Rees Jan 2013

Direct Evidence For Encoding Of Motion Streaks In Human Visual Cortex, Deborah M. Apthorp, D. Samuel Schwarzkopf, C. Kaul, B. Bahrami, David Alais, G. Rees

Faculty of Health and Behavioural Sciences - Papers (Archive)

Temporal integration in the visual system causes fast-moving objects to generate static, oriented traces (‘motion streaks’), which could be used to help judge direction of motion. While human psychophysics and single-unit studies in non-human primates are consistent with this hypothesis, direct neural evidence from the human cortex is still lacking. First, we provide psychophysical evidence that faster and slower motions are processed by distinct neural mechanisms: faster motion raised human perceptual thresholds for static orientations parallel to the direction of motion, whereas slower motion raised thresholds for orthogonal orientations. We then used functional magnetic resonance imaging to measure brain activity …


A Reagentless Thermal Post-Synthetic Rearrangement Of An Allyloxy-Tagged Metal-Organic Framework, Andrew D. Burrows, Sally O. Hunter, Mary F. Mahon, Christopher Richardson Jan 2013

A Reagentless Thermal Post-Synthetic Rearrangement Of An Allyloxy-Tagged Metal-Organic Framework, Andrew D. Burrows, Sally O. Hunter, Mary F. Mahon, Christopher Richardson

Faculty of Science - Papers (Archive)

Direct heating of a metal-organic framework provides a simple, controllable way of effecting a covalent post-synthetic modification. Herein we report that an allyloxy-tagged zinc metal-organic framework undergoes a thermally-promoted aromatic Claisen rearrangement through which the framework connectivity and porosity are maintained.


Bryophyte Species Composition Over Moisture Gradients In The Windmill Islands, East Antarctica: Development Of A Baseline For Monitoring Climate Change Impacts, J Wasley, S A. Robinson, J D. Turnbull, D H. King, W Wanek, M Popp Oct 2012

Bryophyte Species Composition Over Moisture Gradients In The Windmill Islands, East Antarctica: Development Of A Baseline For Monitoring Climate Change Impacts, J Wasley, S A. Robinson, J D. Turnbull, D H. King, W Wanek, M Popp

Faculty of Science - Papers (Archive)

Extreme environmental conditions prevail on the Antarctic continent and limit plant diversity to cryptogamic communities, dominated by bryophytes and lichens. Even small abiotic shifts, associated with climate change, are likely to have pronounced impacts on these communities that currently exist at their physiological limit of survival. Changes to moisture availability, due to precipitation shifts or alterations to permanent snow reserves, will most likely cause greatest impact. In order to establish a baseline for determining the effect of climate change on continental Antarctic terrestrial communities and to better understand bryophyte species distributions in relation to moisture in a floristically important Antarctic …


The Isolation Of Bioactive Flavonoids From Jacaranda Obtusifolia H. B. K. Ssp. Rhombifolia (G. F. W. Meijer) Gentry, Sorachai Khamsan, Saisunee Liawruangrath, Aphiwat Teerawutkulrag, Stephen G. Pyne, Mary J. Garson, Boonsom Liawruangrath Jun 2012

The Isolation Of Bioactive Flavonoids From Jacaranda Obtusifolia H. B. K. Ssp. Rhombifolia (G. F. W. Meijer) Gentry, Sorachai Khamsan, Saisunee Liawruangrath, Aphiwat Teerawutkulrag, Stephen G. Pyne, Mary J. Garson, Boonsom Liawruangrath

Faculty of Science - Papers (Archive)

The paper describes the bioassay-guided isolation, structure elucidation and anticancer evaluation of five flavonoids (-)-liquiritigenin (1), (-)-neoliquiritin (2), isoliquiritigenin (3), isoliquiritin (4) and formononetin (5) from the twigs of Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry. The structures were elucidated based on 1H, 13C NMR, comprehensive 2D NMR, MS analyses and comparison with previously reported spectral data. Compounds 1 and 3 were demonstrated to be inhibitory in vitro against NCI-H187 (small cell lung cancer) with IC50 values of 30.1 and 16.6 μg mL-1, respectively. The isolates were non-cytotoxic to Vero cells (African green monkey kidney).


Translocation Of The Eastern Bristlebird 1: Radio-Tracking Of Post-Release Movements, David Bain, Kris French, Jack Baker, Jean Clarke May 2012

Translocation Of The Eastern Bristlebird 1: Radio-Tracking Of Post-Release Movements, David Bain, Kris French, Jack Baker, Jean Clarke

Faculty of Science - Papers (Archive)

Translocating birds to a new area of habitat to restore or supplement depleted populations may pose a significant threat to the translocated individuals. While for many species, translocated individuals appear to move larger distances than resident animals, species with poor dispersal capacity may be restricted in movements and translocation methods may need to accommodate differences in movements to ensure success. In this study, designed to provide insights to inform our broader programme of translocations in New South Wales, Australia, we investigated post-release movements in the endangered, semi-flightless Eastern Bristlebird (Dasyornis brachypterus). We predicted that movements would be minimal, with few …


Manufacturing On The Move? Beyond The High Dollar In The Debate About Making Things In Australia - The Case Of The Australian Surfboard Industry - Ausccer Discussion Paper No. 2012/2, Andrew Warren, Chris Gibson May 2012

Manufacturing On The Move? Beyond The High Dollar In The Debate About Making Things In Australia - The Case Of The Australian Surfboard Industry - Ausccer Discussion Paper No. 2012/2, Andrew Warren, Chris Gibson

Faculty of Science - Papers (Archive)

In October 2011 surfboard manufacturer BASE abruptly closed its factory on the Gold Coast resulting in the direct loss of 50 jobs. A few days later, nearby D’Arcy Surfboards also announced it was shedding workers and downsizing from a state-of-the art purpose built factory into a backyard workshop. Each business exported surfboards internationally and employed some of Australia’s best known surfboard-makers. The troubles facing these workshops added to those brewing at the very same in Australia’s steel, aluminium, automotive and garment industries. With renewed public debate and media commentary on the future of manufacturing, we now face a crisis in …


Process-Evaluation Of Tropospheric Humidity Simulated By General Circulation Models Using Water Vapor Isotopologues: 1. Comparison Between Models And Observations, Camille Risi, David Noone, John Worden, Christian Frankenberg, Gabriele Stiller, Michael Kiefer, Bernd Funke, Kaley Walker, Peter Bernath, Matthias Schneider, Debra Wunch, Vanessa Sherlock, Nicholas M. Deutscher, David W. Griffith, Paul O. Wennberg, Kimberly Strong, Dan Smale, Emmanuel Mahieu, Sabine Barthlott, Frank Hase, Omar Garcia, Justus Notholt, Thorsten Warneke, Geoffrey Toon, David Sayres, Sandrine Bony, Jeonghoon Lee, Derek Brown, Ryu Uemura, Christophe Sturm Mar 2012

Process-Evaluation Of Tropospheric Humidity Simulated By General Circulation Models Using Water Vapor Isotopologues: 1. Comparison Between Models And Observations, Camille Risi, David Noone, John Worden, Christian Frankenberg, Gabriele Stiller, Michael Kiefer, Bernd Funke, Kaley Walker, Peter Bernath, Matthias Schneider, Debra Wunch, Vanessa Sherlock, Nicholas M. Deutscher, David W. Griffith, Paul O. Wennberg, Kimberly Strong, Dan Smale, Emmanuel Mahieu, Sabine Barthlott, Frank Hase, Omar Garcia, Justus Notholt, Thorsten Warneke, Geoffrey Toon, David Sayres, Sandrine Bony, Jeonghoon Lee, Derek Brown, Ryu Uemura, Christophe Sturm

Faculty of Science - Papers (Archive)

[1] The goal of this study is to determine how H2O and HDO measurements in water vapor can be used to detect and diagnose biases in the representation of processes controlling tropospheric humidity in atmospheric general circulation models (GCMs). We analyze a large number of isotopic data sets (four satellite, sixteen ground-based remote-sensing, five surface in situ and three aircraft data sets) that are sensitive to different altitudes throughout the free troposphere. Despite significant differences between data sets, we identify some observed HDO/H2O characteristics that are robust across data sets and that can be used to evaluate models. We evaluate …


The Role Of Streptokinase As A Virulence Determinant Of Streptococcus Pyogenes - Potential For Therapeutic Targeting, Jason D. Mcarthur, Simon M. Cook, Carola Venturini, Mark J. Walker Mar 2012

The Role Of Streptokinase As A Virulence Determinant Of Streptococcus Pyogenes - Potential For Therapeutic Targeting, Jason D. Mcarthur, Simon M. Cook, Carola Venturini, Mark J. Walker

Faculty of Science - Papers (Archive)

Streptococcus pyogenes is a major human pathogen responsible for numerous diseases ranging from uncomplicated skin and throat infections to severe, life threatening invasive disease such as necrotising fasciitis and streptococcal toxic shock syndrome. These severe invasive infections progress rapidly and produce high rates of morbidity and mortality despite the implementation of aggressive treatment plans. The activation of plasminogen and the acquisition of plasmin activity at the bacterial cell surface is critical for the invasive pathogenesis of this organism. To facilitate this process, S. pyogenes secrete streptokinase, a potent plasminogen activating protein. Here, we describe the role of streptokinase in invasive …


Seed Bank Persistence And Climate Change, Mark K. J Ooi Feb 2012

Seed Bank Persistence And Climate Change, Mark K. J Ooi

Faculty of Science - Papers (Archive)

"The strong mechanistic relationship between climatic factors and seed dormancy and germination suggests that forecast climatic changes will significantly affect seed bank persistence. This review focuses on the potential impact of changing temperature, rainfall and fire regimes on the longevity of long-term persistent seed-banks. Currently, there are few studies investigating the mechanistic responses of demographic processes, such as seed-bank dynamics, to forecast climate change. However, from the work that has been published, several key points have been highlighted. First, increased air temperatures will produce significantly higher soil temperatures in open and sparsely vegetated habitats. Some evidence shows that this could …


Evaluation Of The Evidence Between Consumption Of Refined Grains And Health Outcomes, Peter G. Williams Feb 2012

Evaluation Of The Evidence Between Consumption Of Refined Grains And Health Outcomes, Peter G. Williams

Faculty of Health and Behavioural Sciences - Papers (Archive)

This review evaluates the available evidence on the relationship between consumption of refined grains and health outcomes. A total of 135 relevant articles were identified from database searches of studies published between 2000 and 2010. The great majority found no associations between the intake of refined grain foods and cardiovascular disease, diabetes, weight gain or overall mortality. A few studies found that very high intakes might be associated with some types of cancers, but at moderate levels of consumption the risks were not significant. The totality of evidence shows that consumption of up to 50% of all grain foods as …


Phonic Respiration And Its Impact On Carbon Dioxide Rebreathing In Respiratory Protective Devices, Carmen L. Smith, Jane L. Whitelaw, Brian Davies Jan 2012

Phonic Respiration And Its Impact On Carbon Dioxide Rebreathing In Respiratory Protective Devices, Carmen L. Smith, Jane L. Whitelaw, Brian Davies

Faculty of Health and Behavioural Sciences - Papers (Archive)

Abstract presented at the International Society for Respiratory Protection Sixteenth Biennial Conference, 23-27 September 2012, Boston, United States


Comparison Of The Dietadvice Website In The Clinical Trial And Primary Healthcare Contexts, Yasmine Probst, Kathryn Boyd, Virva Walkington, Linda C. Tapsell Jan 2012

Comparison Of The Dietadvice Website In The Clinical Trial And Primary Healthcare Contexts, Yasmine Probst, Kathryn Boyd, Virva Walkington, Linda C. Tapsell

Faculty of Health and Behavioural Sciences - Papers (Archive)

The aim of this study was to evaluate the use of the DietAdvice website, a self-administered online dietary assessment, in the context of a dietary intervention randomized controlled trial [ACTRN 12608000425392]. Data available from a total of n=118 volunteers recruited to the dietary trial and using the website in the clinic at t=0, 3 and 12mo was compared with that obtained from diet histories (DH) and 3-day food record (FR). Fasting blood samples from these time points were also correlated with the macronutrient values obtained. Complete web based records were obtained for 65% of participants at t=0, 83% at t=3 …


Vection Can Be Induced Without Global-Motion Awareness, Takeharu Seno, Stephen A. Palmisano, Hiroyuki Ito, Shoji Sunaga Jan 2012

Vection Can Be Induced Without Global-Motion Awareness, Takeharu Seno, Stephen A. Palmisano, Hiroyuki Ito, Shoji Sunaga

Faculty of Health and Behavioural Sciences - Papers (Archive)

A new vection illusion is reported. Vection was induced even though there was no consciously perceived global display motion corresponding to the self-motion. The resulting experience can be summarised as: ``I feel that I am moving but I do not know why''.


A Comparison Of Treatment Outcomes For Individuals With Substance Use Disorder Alone And Individuals With Probable Dual Diagnosis, Elizabeth K. Cridland, Frank P. Deane, Ching-I Hsu, Peter J. Kelly Jan 2012

A Comparison Of Treatment Outcomes For Individuals With Substance Use Disorder Alone And Individuals With Probable Dual Diagnosis, Elizabeth K. Cridland, Frank P. Deane, Ching-I Hsu, Peter J. Kelly

Faculty of Health and Behavioural Sciences - Papers (Archive)

The co-occurrence of substance use and mental health problems, often referred to as dual diagnosis (DD), is increasingly recognised as commonplace within substance abuse treatment programs. Two-hundred and thirty-four individuals from 9 Australian Salvation Army drug and alcohol rehabilitation programs completed a 3-month post-discharge telephone follow-up. Using a cut-off score from the Psychiatric Subscale of the Addiction Severity Index (5th ed.), 66.7% were classified as likely to have DD and 33.3% as substance use disorder only (SUD). Both groups reported comparable and decreased substance use levels at follow-up, yet DD individuals perceived less improvement in substance use problems. Comparable improvements …


Directionless Vection: A New Illusory Self-Motion Perception, Takeharu Seno, Y Yamada, Stephen A. Palmisano Jan 2012

Directionless Vection: A New Illusory Self-Motion Perception, Takeharu Seno, Y Yamada, Stephen A. Palmisano

Faculty of Health and Behavioural Sciences - Papers (Archive)

We report a new visual illusion, "directionless vection." When expanding and contracting optic flows are simultaneously presented in the same depth plane, observers can perceive illusory self-motion (vection) without direction


Roles Of Extracellular Chaperones In Amyloidosis, Amy R. Wyatt, Justin J. Yerbury, Rebecca A. Dabbs, Mark R. Wilson Jan 2012

Roles Of Extracellular Chaperones In Amyloidosis, Amy R. Wyatt, Justin J. Yerbury, Rebecca A. Dabbs, Mark R. Wilson

Faculty of Science - Papers (Archive)

Extracellular protein misfolding and aggregation underlie many of the most serious amyloidoses including Alzheimer's disease, spongiform encephalopathies and type II diabetes. Despite this, protein homeostasis (proteostasis) research has largely focussed on characterising systems that function to monitor protein conformation and concentration within cells. We are now starting to identify elements of corresponding systems, including an expanding family of secreted chaperones, which exist in the extracellular space. Like their intracellular counterparts, extracellular chaperones are likely to play a central role in systems that maintain proteostasis; however, the precise details of how they participate are only just emerging. It is proposed that …


Architecture And Conservation Of The Bacterial Dna Replication Machinery, An Underexploited Drug Target, Andrew Robinson, Rebecca J. Causer, Nicholas E. Dixon Jan 2012

Architecture And Conservation Of The Bacterial Dna Replication Machinery, An Underexploited Drug Target, Andrew Robinson, Rebecca J. Causer, Nicholas E. Dixon

Faculty of Science - Papers (Archive)

"New antibiotics with novel modes of action are required to combat the growing threat posed by multi-drug resistant bacteria. Over the last decade, genome sequencing and other high-throughput techniques have provided tremendous insight into the molecular processes underlying cellular functions in a wide range of bacterial species. We can now use these data to assess the degree of conservation of certain aspects of bacterial physiology, to help choose the best cellular targets for development of new broad-spectrum antibacterials. DNA replication is a conserved and essential process, and the large number of proteins that interact to replicate DNA in bacteria are …


The Extracellular Chaperone Clusterin Sequesters Oligomeric Forms Of The Amyloid-Beta 1-40 Peptide, Priyanka Narayan, Angel Orte, Richard W. Clarke, Benedetta Bolognesi, Sharon Hook, Kristina A. Ganzinger, Sarah Meehan, Mark R. Wilson, Christopher M. Dobson, David Klenerman Jan 2012

The Extracellular Chaperone Clusterin Sequesters Oligomeric Forms Of The Amyloid-Beta 1-40 Peptide, Priyanka Narayan, Angel Orte, Richard W. Clarke, Benedetta Bolognesi, Sharon Hook, Kristina A. Ganzinger, Sarah Meehan, Mark R. Wilson, Christopher M. Dobson, David Klenerman

Faculty of Science - Papers (Archive)

In recent genome-wide association studies, the extracellular chaperone protein, clusterin, has been identified as a newly-discovered risk factor in Alzheimer's disease. We have examined the interactions between human clusterin and the Alzheimer's disease-associated amyloid-β 1-40 peptide (Aβ 1-40), which is prone to aggregate into an ensemble of oligomeric intermediates implicated in both the proliferation of amyloid fibrils and in neuronal toxicity. Using highly sensitive single-molecule fluorescence methods, we have found that Aβ 1-40 forms a heterogeneous distribution of small oligomers (from dimers to 50-mers), all of which interact with clusterin to form long-lived, stable complexes. Consequently, clusterin is able …


Investigating Arsenic Speciation And Mobilization In Sediments With Dgt And Det: A Mesocosm Evaluation Of Oxic-Anoxic Transitions, William W. Bennett, Peter R. Teasdale, Jarad G. Panther, David T. Welsh, Huijun Zhao, Dianne F. Jolley Jan 2012

Investigating Arsenic Speciation And Mobilization In Sediments With Dgt And Det: A Mesocosm Evaluation Of Oxic-Anoxic Transitions, William W. Bennett, Peter R. Teasdale, Jarad G. Panther, David T. Welsh, Huijun Zhao, Dianne F. Jolley

Faculty of Science - Papers (Archive)

Mobilization of arsenic from freshwater and estuarine sediments during the transition from oxic to anoxic conditions was investigated using recently developed diffusive sampling techniques. Arsenic speciation and Fe(II) concentrations were measured at high resolution (1−3 mm) with in situ diffusive gradients in thin films (DGT) and diffusive equilibration in thin films (DET) techniques. Water column anoxia induced Fe(II) and As(III) fluxes from the sediment. A correlation between water column Fe(II) and As(III) concentrations was observed in both freshwater (rs = 0.896, p < 0.001) and estuarine (rs = 0.557, p < 0.001) mesocosms. Porewater sampling by DGT and DET techniques confirmed that arsenic mobilization was associated with the reductive dissolution of Fe(III) (hydr)oxides in the suboxic zone of the sediment; a relationship that was visible because of the ability to measure the coincident profiles of these species using combined DGT and DET samplers. The selective measurement of As(III) and total inorganic arsenic by separate DGT samplers indicated that As(III) was the primary species mobilized from the solid phase to the porewater. This measurement approach effectively ruled out substantial As(V) mobilization from the freshwater and estuarine sediments in this experiment. This study demonstrates the capabilities of the DGT and DET techniques for investigating arsenic speciation and mobilization over a range of sediment conditions.


Optimization Of Colorimetric Det Technique For The In Situ, Two-Dimensional Measurement Of Iron(Ii) Distributions In Sediment Porewaters, William W. Bennett, Peter R. Teasdale, David T. Welsh, Jarad G. Panther, Dianne F. Jolley Jan 2012

Optimization Of Colorimetric Det Technique For The In Situ, Two-Dimensional Measurement Of Iron(Ii) Distributions In Sediment Porewaters, William W. Bennett, Peter R. Teasdale, David T. Welsh, Jarad G. Panther, Dianne F. Jolley

Faculty of Science - Papers (Archive)

No abstract provided.


Atmospheric Tomography: A Bayesian Inversion Technique For Determining The Rate And Location Of Fugitive Emissions, Ruhi Humphries, Charles Jenkins, Ray Leuning, Steve Zegelin, David Griffith, Christopher Caldow, Henry Berko, Andrew Feitz Jan 2012

Atmospheric Tomography: A Bayesian Inversion Technique For Determining The Rate And Location Of Fugitive Emissions, Ruhi Humphries, Charles Jenkins, Ray Leuning, Steve Zegelin, David Griffith, Christopher Caldow, Henry Berko, Andrew Feitz

Faculty of Science - Papers (Archive)

A Bayesian inversion technique to determine the location and strength of trace gas emissions from a point source in open air is presented. It was tested using atmospheric measurements of N2O and CO2 released at known rates from a source located within an array of eight evenly spaced sampling points on a 20 m radius circle. The analysis requires knowledge of concentration enhancement downwind of the source and the normalized, three-dimensional distribution (shape) of concentration in the dispersion plume. The influence of varying background concentrations of ~1% for N2O and ~10% for CO2 was removed by subtracting upwind concentrations from …


Inorganic Arsenic And Iron(Ii) Distributions In Sediment Porewaters Investigated By A Combined Dgt - Colourimetric Det Technique, William Bennett, Peter R. Teasdale, David T. Welsh, Jarad Panther, Ryan R. Stewart, Helen L. Price, Dianne F. Jolley Jan 2012

Inorganic Arsenic And Iron(Ii) Distributions In Sediment Porewaters Investigated By A Combined Dgt - Colourimetric Det Technique, William Bennett, Peter R. Teasdale, David T. Welsh, Jarad Panther, Ryan R. Stewart, Helen L. Price, Dianne F. Jolley

Faculty of Science - Papers (Archive)

No abstract provided.