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The Study Of High Intensity Interval Training's Effect On Enjoyment, Keali Mari 2021 University of Nebraska at Omaha

The Study Of High Intensity Interval Training's Effect On Enjoyment, Keali Mari

Theses/Capstones/Creative Projects

This study assessed participant’s level of enjoyment in high-intensity training over moderate intensity-training. High intensity interval training is defined as short bouts of exercise performed at a near-maximal effort with rest periods or light activity in between. High intensity interval training involves repeatedly exercising at a high intensity for 30 seconds to several minutes, separated by 1-5 minutes of recovery. This type of exercise has sparked the interest of many active people due to its decreased time commitment and the benefits it elicits. The results of this study show that high intensity interval training induces a higher enjoyment rate ...


Anti-Cancer Effects By Interleukin 24, Xuelin Zhong 2021 The Graduate Center, City University of New York

Anti-Cancer Effects By Interleukin 24, Xuelin Zhong

Dissertations, Theses, and Capstone Projects

Cancers develop as some cells acquire the ability, either by exogenous stimulation or by spontaneous mutation, to keep growing despite normal restraints. Up-regulating translation of oncogenes involved in cell proliferation and tumor development and down-regulating translation of tumor-suppressors that normally suppress tumor development are two most common mechanisms by which cancers develop. Therefore, it is crucial to study how these proteins get either up-regulated or down-regulated at translational level.

The eukaryotic translation initiation factor, which is composed of subunits such as eIF4A, eIF4G and eIF4E, is one of the key factors that contribute to efficient translation initiation. Interleukin 24 (IL-24 ...


Mitochondrial Aspects Of Neuronal Pathology In Triple-Transgenic Alzheimer’S Disease Mice, John Zachary Cavendish 2021 West Virginia University

Mitochondrial Aspects Of Neuronal Pathology In Triple-Transgenic Alzheimer’S Disease Mice, John Zachary Cavendish

Graduate Theses, Dissertations, and Problem Reports

Alzheimer’s disease (AD) is a fatal, progressive neurodegenerative disease afflicting millions of people in the United States alone and is the only one of the top leading causes of morbidity and mortality with no effective disease-modifying therapies. It is the most common form of dementia, affecting one in three people over the age of 85. While the hallmarks of the disease include accumulation of beta-amyloid-based extracellular plaques and hyperphosphorylated tau-based intracellular neurofibrillary tangles, treatment strategies centered on removing or mitigating these components of AD have all failed in humans. Mitochondrial dysfunction has been increasingly recognized as an early and ...


A Christian Guide To Body Stewardship, Diet And Exercise, David D. Peterson, Jeremy M. Kimble, Trent A. Rogers, Don Cameron Davis 2021 Cedarville University

A Christian Guide To Body Stewardship, Diet And Exercise, David D. Peterson, Jeremy M. Kimble, Trent A. Rogers, Don Cameron Davis

Cedrus Press Publications

No abstract provided.


Intellectual Property As A Determinant Of Health, Ana Santos Rutschman 2021 Saint Louis University - School of Law

Intellectual Property As A Determinant Of Health, Ana Santos Rutschman

All Faculty Scholarship

Public health literature has long recognized the existence of determinants of health, a set of socio-economic conditions that affect health risks and health outcomes across the world. The World Health Organization defines these determinants as “forces and systems” consisting of “factors combin[ing] together to affect the health of individuals and communities.” Frameworks relying on determinants of health have been widely adopted by countries in the global South and North alike, as well as international institutional players, several of which are direct or indirect players in transnational intellectual property (IP) policymaking. Issues raised by the implementation of IP policies, however ...


Metabolic Coordination Of Stem Cell Fate Controls Tumor Initiation And Tissue Repair, Sanjeethan C. Baksh 2021 Rockefeller University

Metabolic Coordination Of Stem Cell Fate Controls Tumor Initiation And Tissue Repair, Sanjeethan C. Baksh

Student Theses and Dissertations

Tissue stem cells balance fate decisions of self-renewal and differentiation to maintain homeostasis over the lifetime of an organism, as well as to repair tissues upon injury and wounding. Disrupting the balance between self-renewal and differentiation results in pathology: excessive self-renewal at the expense of differentiation is associated with tumor initiation, whereas failure to properly self-renew leads to stem cell exhaustion and aging. Stem cell fate is under tight regulation by the surrounding microenvironment, or niche, which includes neighboring cell types, signaling molecules, extracellular matrix, and nutrients. While the role of stromal cells and the signals they produce has been ...


The Intellectual Property Of Covid-19, Ana Santos Rutschman 2021 Saint Louis University School of Law

The Intellectual Property Of Covid-19, Ana Santos Rutschman

All Faculty Scholarship

The response to COVID-19 is indissolubly tied to intellectual property. In an increasingly globalized world in which infectious disease pathogens travel faster and wider than before, the development of vaccines, treatments and other forms of medical technology has become an integral part of public health preparedness and response frameworks. The development of these technologies, and to a certain extent the allocation and distribution of resulting outputs, is informed by intellectual property regimes. These regimes influence the commitment of R&D resources, shape scientific collaborations and, in some cases, may condition the widespread availability of emerging technologies. As seen throughout this ...


Interpretation Of Psychiatric Genome-Wide Association Studies With Multispecies Heterogeneous Functional Genomic Data Integration., Timothy Reynolds, Emma C Johnson, Spencer B Huggett, Jason A. Bubier, Rohan H C Palmer, Arpana Agrawal, Erich J Baker, Elissa J Chesler 2021 The Jackson Laboratory

Interpretation Of Psychiatric Genome-Wide Association Studies With Multispecies Heterogeneous Functional Genomic Data Integration., Timothy Reynolds, Emma C Johnson, Spencer B Huggett, Jason A. Bubier, Rohan H C Palmer, Arpana Agrawal, Erich J Baker, Elissa J Chesler

Faculty Research 2021

Genome-wide association studies and other discovery genetics methods provide a means to identify previously unknown biological mechanisms underlying behavioral disorders that may point to new therapeutic avenues, augment diagnostic tools, and yield a deeper understanding of the biology of psychiatric conditions. Recent advances in psychiatric genetics have been made possible through large-scale collaborative efforts. These studies have begun to unearth many novel genetic variants associated with psychiatric disorders and behavioral traits in human populations. Significant challenges remain in characterizing the resulting disease-associated genetic variants and prioritizing functional follow-up to make them useful for mechanistic understanding and development of therapeutics. Model ...


The Role Of Nutrient Availability In Therapeutic Response Of Leukemia, Rohiverth Guarecuco Jr 2021 Rockefeller University

The Role Of Nutrient Availability In Therapeutic Response Of Leukemia, Rohiverth Guarecuco Jr

Student Theses and Dissertations

Tumor environment influences the response to anti-cancer therapy, but which extracellular nutrients impact drug sensitivity is largely unknown. In this work, we used functional genomics to identify metabolic modifiers of the response to L-asparaginase (ASNase), a therapy that depletes plasma asparagine and targets leukemic cells with insufficient asparagine synthesis. Our approach revealed thiamine pyrophosphate kinase 1 (TPK1), which converts vitamin B1 (thiamine) into the cofactor thiamine pyrophosphate (TPP), as a metabolic dependency under ASNase treatment. In glutamine-anaplerotic leukemia cells, we found that TPP availability enables asparagine synthesis from extracellular glutamine. Mechanistically, TPP is critical for the activity of alpha-ketoglutarate dehydrogenase ...


Identification And Characterization Of A Pseudomonas Aeruginosa Bacteriophage, Rachel Persinger 2020 James Madison University

Identification And Characterization Of A Pseudomonas Aeruginosa Bacteriophage, Rachel Persinger

Senior Honors Projects, 2020-current

Growing antibiotic resistance of the human pathogen, Pseudomonas aeruginosa, has become a great concern in healthcare as many current treatment options are being exhausted. Thus, an interest in phage therapy has developed as a possible treatment to alleviate this problem. In this study, bacteriophages that infect P. aeruginosa were isolated and analyzed. Two methods of discovery were used to isolate potential phages using P. aeruginosa clinical isolates. A direct method used environmental samples to test for infection of one of four P. aeruginosa clinical isolates. As a result, one clinical isolate-infecting phage was found. It was sequenced and named “Persinger ...


Corn And Soybean Response To Wastewater-Recycled Phosphorus Fertilizers, Shane Ylagan 2020 University of Arkansas, Fayetteville

Corn And Soybean Response To Wastewater-Recycled Phosphorus Fertilizers, Shane Ylagan

Crop, Soil and Environmental Sciences Undergraduate Honors Theses

The ability to recycle phosphorus (P) from wastewaters could provide a sustainable, continuous source of P that might also help protect surface water quality from P enrichment. The mineral struvite (MgNH4PO4·6H2O) is an understudied material that can be created from Pcontaining wastewater and has been shown to have agricultural fertilizer value. The objective of this study was to evaluate the effects of electrochemically precipitated struvite (ECST), chemically precipitated struvite (Crystal Green; CG), diammonium phosphate (DAP), monoammonium phosphate (MAP), rock phosphate (RP), and triple super phosphate (TSP) on corn (Zea mays) and soybean (Glycine max) response in a 79-day greenhouse ...


Block Periodization Programming: Efficacy In Subjects Of Differing Strength Levels, Paul Moquin 2020 East Tennessee State University

Block Periodization Programming: Efficacy In Subjects Of Differing Strength Levels, Paul Moquin

Electronic Theses and Dissertations

Physiological muscle adaptations due to resistance training are still not fully known. The rate and area of hypertrophy could drastically help or hinder athletic performance. The purpose of this study was to observe the changes in lean body mass (and related factors), relative allometrically scaled strength and absolute strength through an 11-week block periodized resistance training program. The subjects (n = 15) realized an increase in total body water (pre = 49.77Kg; post = 51.70Kg), lean body mass (pre = 67.98Kg; post = 70.63Kg), adjusted lean body mass (pre = 20.35Kg; post = 21.03Kg) and cross sectional area (pre = 32.73 ...


Responses Of Juvenile Atlantic Salmon To Competition And Environmental Change: Implications For Performance In Maine Streams, Nicole C. Ramberg-Pihl 2020 University of Maine

Responses Of Juvenile Atlantic Salmon To Competition And Environmental Change: Implications For Performance In Maine Streams, Nicole C. Ramberg-Pihl

Electronic Theses and Dissertations

New England’s climate is changing faster than that of any other region in the continental United States. Over the last century, Maine has experienced an increase in annual temperature of approximately 1.48oC along with a 15 percent increase in annual precipitation. Temperature and precipitation play vital roles in shaping the ecology of freshwater environments. Therefore, changes in regional climate could undermine the structure and stability of Maine’s freshwater systems as they currently exist.

Maine currently harbors the last wild populations of Atlantic salmon (Salmo salar) in the United States. Atlantic salmon were once abundant in ...


Biomechanical Properties Of Land Based And Shallow Water Wait: A Comparative Review Of Literature, Mostafa Yaghoubi, Philip Fink, Wyatt H. Page, Sarah P. Shultz 2020 Massey University, Wellington

Biomechanical Properties Of Land Based And Shallow Water Wait: A Comparative Review Of Literature, Mostafa Yaghoubi, Philip Fink, Wyatt H. Page, Sarah P. Shultz

International Journal of Aquatic Research and Education

Aquatic locomotion exercises are frequently used in rehabilitation and cross-training for land-based athletes. Hydrostatic pressure, thermal conductivity and drag force affect a person's ability to move; therefore, it is important to understand differences of biomechanical gait in water vs land. This review investigated biomechanical differences between shallow water and land-based exercises. PubMed, Google Scholar, SPORTDiscus and Scopus were searched; 33 studies included walking forward (27), backward (6) and running (6). Electromyographic amplitude was similar or less in submaximal intensity during aquatic gait, in comparison to on land. At maximal intensities, however, the amplitude was similar (n=5) or higher ...


Habitat, Diet, And Foraging Ecology Of Willow Flycatcher In Sierra Nevada Meadows, Scott E. Dietrich 2020 Utah State University

Habitat, Diet, And Foraging Ecology Of Willow Flycatcher In Sierra Nevada Meadows, Scott E. Dietrich

All Graduate Theses and Dissertations

The last stronghold of the California Willow Flycatcher (Empidonax traillii) population, which exists in the Sierra Nevada, continues to decline, necessitating a clearer understanding of how meadows provide habitat for the species. To gain this understanding, we assessed vegetation type, saturation levels, and invertebrate species at 51 different sites within four meadows located in the Little Truckee River drainage. 17 of these sites were occupied by nesting Willow Flycatcher during the time of the study, 17 sites had been occupied by nesting Willow Flycatcher in annual surveys between 1997 and 2010 but are no longer used, and 17 sites had ...


Finding The Balance​ The Effects Of Α-Cyclodextrin, 2-Hydroxypropyl-Β-Cyclodextrin, And Cholesterol Bacteroides Vulgatus And Clostridium Bolteae​, Bethany Weaver 2020 Olivet Nazarene University

Finding The Balance​ The Effects Of Α-Cyclodextrin, 2-Hydroxypropyl-Β-Cyclodextrin, And Cholesterol Bacteroides Vulgatus And Clostridium Bolteae​, Bethany Weaver

Pence-Boyce STEM Student Scholarship

Atherosclerosis is a cardiovascular disease that is characterized by the hardening of arteries through the formation of cholesterol plaques. Cyclodextrins could potentially treat atherosclerosis by shrinking plaques. These cyclic oligosaccharides can make complexes with cholesterol but have also shown toxic side effects. This study looked for potential negative effects of cyclodextrins and cholesterol on gut bacteria. It was hypothesized that Bacteroides vulgatus will have decreased growth when grown in broth with cholesterol. In contrast, Clostridium bolteae will have decreased growth when grown in broth with cyclodextrins. Due to the fact that these bacteria are anaerobic, Clostridium bolteae and Bacteroides vulgatus ...


Nodulation And Growth Of Shepherdia × Utahensis ‘Torrey’, Ji-Jhong Chen 2020 Utah State University

Nodulation And Growth Of Shepherdia × Utahensis ‘Torrey’, Ji-Jhong Chen

All Graduate Theses and Dissertations

Shepherdia ×utahensis ‘Torrey’ (Elaeagnaceae) is a hybrid of two native actinorhizal plants in the Intermountain West, S. argentea (silver buffaloberry) and S. rotundifolia (roundleaf buffaloberry). Due to actinorhizal symbiosis, atmospheric nitrogen (N2) can be converted to ammonium, a bioavailable form. Actinorhizal plants have great value in sustainable nursery production and urban landscape use. However, nitrogen fertilizer negatively affects the nodulation of actinorhizal plants. As a newly developed hybrid, both the symbiont identity and nodule formation of S. ×utahensis ‘Torrey’ remain largely unknown. Therefore, experiments were conducted to investigate the nodule formation of S. ×utahensis ‘Torrey’ inoculated with field soils ...


Examination And Empirical Forecast Of Wheat Yield In Northwest India Based On Climate And Socio-Economic Factors, Avik Mukherjee 2020 Utah State University

Examination And Empirical Forecast Of Wheat Yield In Northwest India Based On Climate And Socio-Economic Factors, Avik Mukherjee

All Graduate Theses and Dissertations

This study summarizes the findings of research organized in two parts. The first part includes the impact of climate and socio-economic factors that affected wheat yield in northwest India during the 2000s. The second part focused on the forecast of average wheat yield for the two highest wheat producing states Punjab and Haryana.

Initial study focused on the impact of climate factors on wheat yield in northwest India. It has been found that above normal temperature coupled with water shortage i.e. irregular irrigation and low soil moisture contributed to the prolonged yield reduction during 2002-2010.

Next, we reviewed the ...


Demographics, Accuracy, And Impact Of Feed Laboratories In The United States, Jerald H. Severe 2020 Utah State University

Demographics, Accuracy, And Impact Of Feed Laboratories In The United States, Jerald H. Severe

All Graduate Theses and Dissertations

Feed analysis is very important to modern society. In the United States feed analysis is used to optimize production of food animals. Feed analysis is also used as a tool to place value on crops. As important as feed analysis is to society, little research has been done that describes which feed laboratories are the most popular and why people use them. It has been thought by some patrons that different results from the same feed sample are obtained by different laboratories. Is this true? If so, what is the effect on those that use feed laboratories to produce animals ...


Applied Species Delimitation In Microbial Taxa And Plants, Austin C. Koontz 2020 Utah State University

Applied Species Delimitation In Microbial Taxa And Plants, Austin C. Koontz

All Graduate Theses and Dissertations

Species are a fundamental concept in biology, and many subdisciplines in biology utilize species in aspects of theory and in the communication of results. Given the centrality of species in biological science, it can seem surprising that there is no universal definition amongst biologists of what, strictly speaking, a species is. In fact, there are, by some estimates, over 20 different "species concepts", and this lack of a consensus is termed "the species problem". This problem has theoretical underpinnings, but has become more relevant as advances in sequencing technologies over the past two decades have allowed researchers to probe the ...


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