Targeting The Cerebrovasculature In Sepsis: A Focus On The Brain Microvascular Endothelium,
2023
West Virginia University
Targeting The Cerebrovasculature In Sepsis: A Focus On The Brain Microvascular Endothelium, Divine C. Nwafor
Graduate Theses, Dissertations, and Problem Reports
The blood-brain barrier (BBB) is a critical interface between the systemic circulation and the brain. It is a specialized multicellular unit composed of brain microvascular endothelial cells (BMECs), pericytes, a basement membrane, and astrocytic end foot processes. BMECs are a principal component of the BBB that provide the structural framework needed for the stringent transport of molecules into the brain. BMEC dysfunction permits the trafficking of neurotoxins from systemic circulation into the brain, which ultimately exacerbates BBB dysfunction and neuroinflammation. Studies have shown that BBB dysfunction is a key determinant of cognitive decline in sepsis. However, there are critical knowledge ...
A Review On Nanomaterials And Nanohybrids Based Bio-Nanocomposites For Food Packaging,
2022
Technological University Dublin
A Review On Nanomaterials And Nanohybrids Based Bio-Nanocomposites For Food Packaging, Kalpani Y. Perera, Amit K. Jaiswal, Swarna Jaiswal
Articles
With an increasing demand for a novel, eco-friendly, high-performance packaging material “bio-nanocomposites” has attracted great attention in recent years. The review article aims at to evaluating recent innovation in bio-nanocomposites for food packaging applications. The current trends and research over the last three years of the various bio-nanocomposites including inorganic, organic nanomaterials, and nanohybrids, which are suitable as food packaging materials due to their advanced properties such as high mechanical, thermal, barrier, antimicrobial, and antioxidant are described in detail. In addition, the legislation, migration studies, and SWOT analysis on bio-nanocomposite film have been discussed. It has been observed that the ...
Wildfires Enhance Phytoplankton Production In Tropical Oceans,
2022
Edith Cowan University
Wildfires Enhance Phytoplankton Production In Tropical Oceans, Dongyan Liu, Chongran Zhou, John K. Keesing, Oscar Serrano, Axel Werner, Yin Fang, Yingjun Chen, Pere Masque, Janine Kinloch, Aleksey Sadekov, Yan Du
Research outputs 2022 to 2026
Wildfire magnitude and frequency have greatly escalated on a global scale. Wildfire products rich in biogenic elements can enter the ocean through atmospheric and river inputs, but their contribution to marine phytoplankton production is poorly understood. Here, using geochemical paleo-reconstructions, a century-long relationship between wildfire magnitude and marine phytoplankton production is established in a fire-prone region of Kimberley coast, Australia. A positive correlation is identified between wildfire and phytoplankton production on a decadal scale. The importance of wildfire on marine phytoplankton production is statistically higher than that of tropical cyclones and rainfall, when strong El Niño Southern Oscillation coincides with ...
Mirnas Levels In A Streptozocin Model Of Alzheimer’S Disease,
2022
American University in Cairo
Mirnas Levels In A Streptozocin Model Of Alzheimer’S Disease, Nada Moustafa
Theses and Dissertations
Dementia entails a progressive decrease in cognitive functions, with 50%-75% of cases attributed to Alzheimer’s disease (AD); an aging-associated condition characterized by the build-up of tangled phosphorylated Tau (p-Tau) protein and beta-amyloid (Aβ) depositions. Sporadic AD (sAD) is multifactorial in nature, resulting from a combination of environmental and genetic predisposing factors. Type 2 diabetes mellitus (T2DM) is a leading risk factor for dementia, and deregulation of brain glucose metabolism is associated with early cognitive affection in sAD. Thus, the diabetogenic agent Streptozotocin (STZ) is used to experimentally create an AD model in animals (STZ-induced sAD), in which abnormalities ...
The Impact Of Focused Attention And Opening Monitoring Meditation Styles On Attention,
2022
The Graduate Center, City University of New York
The Impact Of Focused Attention And Opening Monitoring Meditation Styles On Attention, Jennifer Wheary
Dissertations, Theses, and Capstone Projects
Mindfulness meditation – often broken down into two distinct types, focused attention (FA) and open monitoring (OM) – has been associated with a range of affective and attentional benefits. Using an attentional blink (AB) paradigm that demonstrated improved attention for novice FA meditators, we explored whether novices who engaged in a single, brief bout of meditation exhibited any differences in alpha or theta power during meditation, and whether these differences were apparent by meditation type. In the AB paradigm, participants are asked to identify two targets, T1 and T2, which are separated by 200-500 ms. Our results showed no significant differences between ...
Cdc6 Is Sequentially Regulated By Pp2a-Cdc55, Cdc14, And Sic1 For Origin Licensing In S. Cerevisiae,
2022
The Graduate Center, City University of New York
Cdc6 Is Sequentially Regulated By Pp2a-Cdc55, Cdc14, And Sic1 For Origin Licensing In S. Cerevisiae, Jasmin Philip
Dissertations, Theses, and Capstone Projects
Control of DNA replication is critical for progression of the cell cycle and genomic stability. Cyclin-dependent kinases (CDKs) coordinate numerous phosphorylation events to accomplish two biological tasks for all living organisms: DNA replication and cell division. One CDK, Cyclin-Cdc28, is responsible for cell cycle progression in budding yeast. DNA replication requires a stepwise assembly of the pre-replicative complex on DNA, including Orc1-6, Cdc6, Cdt1 and Mcm2-7, during M-G1 phase. Cdc6 contains eight Cdc28 consensus sites, SP or TP motifs. Clb5-Cdc28 phosphorylates Cdc6-T7 to recruit Cks1, the Cdc28 phospho-adaptor, for subsequent multisite phosphorylation during S phase. There are two phospho-degrons at ...
Utility Of The Motivation To Change Lifestyle And Health Behaviors For Dementia Risk Reduction Scale (Mclhb-Drr) Based On A North American Sample,
2022
National Louis University
Utility Of The Motivation To Change Lifestyle And Health Behaviors For Dementia Risk Reduction Scale (Mclhb-Drr) Based On A North American Sample, Angelina E. Witbeck
Dissertations
As the population ages, the prevalence rates of dementia continue to increase. Without a cure or promising treatment for dementia, the best course of lowering the prevalence rates of dementia is through preventative measures. Through an electronic survey, the study utilized the MCLHB-DRR scale to determine whether (1) gender, age, educational background, and socioeconomic status will impact the motivational factors to change lifestyle and health behaviors to reduce the risk of developing dementia and (2) direct experiences with individuals that have a dementia diagnosis are likely to impact one's motivational factors to change lifestyle and health behaviors to reduce ...
A Cross-Country Investigation Of Social Image Motivation And Acceptance Of Lab-Grown Meat In Singapore And The United States,
2022
Singapore Management University
A Cross-Country Investigation Of Social Image Motivation And Acceptance Of Lab-Grown Meat In Singapore And The United States, Mark Chong, Angela K. Y. Leung, Verity Lua
Research Collection Lee Kong Chian School Of Business
This research has three goals. First, it sets out to compare consumer acceptance of lab-grown meat in the U.S. and in Singapore. Second, it seeks to explain the difference in Americans' and Singaporeans' acceptance of lab-grown meat by examining their eating motivations. Specifically, we focused on social image motivations – the motivations to present oneself positively in social contexts. Third, this study also aims to assess if exposure to information about lab-grown meat communicated by celebrity versus expert social media influencers (SMIs) can impact people's acceptance of lab-grown meat products. Our analysis showed that Singaporean participants had greater acceptance ...
The Neurobiology Of The Healing Arts: Expressive Arts Therapy As An Effective Treatment For Adults Diagnosed With Complex Ptsd Due To Complex Trauma In Childhood: A Literature Review,
2022
Lesley University
The Neurobiology Of The Healing Arts: Expressive Arts Therapy As An Effective Treatment For Adults Diagnosed With Complex Ptsd Due To Complex Trauma In Childhood: A Literature Review, Cheryl Ratliff
Expressive Therapies Capstone Theses
Empirically based therapies for posttraumatic stress disorder (PTSD) have been found to be less effective in treating more severe trauma presentations such as complex PTSD (CPTSD). Neurobiological investigation provides a framework for examining the physical and psychological effects of trauma on brain and nerve structures and provides insight into how to effectively treat CPTSD. This literature review examined symptomology of CPTSD resulting from complex trauma in childhood, neurobiological effects of trauma and their implications for treatment, and the efficacy of the current treatment models, primarily those of eye movement desensitization and reprocessing (EMDR), narrative exposure therapy (NET), and somatic psychotherapies ...
3. Parallel Session,
2022
Virginia Commonwealth University
3. Parallel Session, Parallel Session
Biology and Medicine Through Mathematics Conference
No abstract provided.
Coffee Break,
2022
Virginia Commonwealth University
Coffee Break, Coffee Break
Biology and Medicine Through Mathematics Conference
No abstract provided.
2. Parallel Sessions,
2022
Virginia Commonwealth University
2. Parallel Sessions, Parallel Sessions
Biology and Medicine Through Mathematics Conference
No abstract provided.
Lunch- On Your Own,
2022
Virginia Commonwealth University
Lunch- On Your Own, Lunch
Biology and Medicine Through Mathematics Conference
No abstract provided.
1. Parallel Sessions,
2022
Virginia Commonwealth University
1. Parallel Sessions, Parallel Sessions
Biology and Medicine Through Mathematics Conference
No abstract provided.
Networking Coffee Break,
2022
Virginia Commonwealth University
Networking Coffee Break, First Floor Lobby
Biology and Medicine Through Mathematics Conference
No abstract provided.
Length-Based Risk Analysis Of Management Options For The Southern Florida Usa Multispecies Coral Reef Fish Fishery,
2022
University of Miami
Length-Based Risk Analysis Of Management Options For The Southern Florida Usa Multispecies Coral Reef Fish Fishery, Jerald Ault, Steven G. Smith, Matthew W. Johnson, Laura Jay W. Grove, James A. Bohnsack, Gerard T. Dinardo, Caroline Mclaughlin, Nelson M. Ehrhardt, Vanessa Mcdonough, Michael P. Seki, Steven Miller, Jiangang Luo, Jeremiah Blondeau, Michael P. Crosby, Glenn Simpson, Mark E. Monaco, Clayton G. Pollock, Michael W. Feeley, Alejandro Acosta
Marine & Environmental Sciences Faculty Articles
Exploitation impacts and management options for 15 coral reef fish species central to the commercial and recreational fisheries of the southern Florida USA coral reef ecosystem were evaluated using a length-based risk analysis (LBRA) framework. Population abundance-at-length composition data were obtained from several regional federal-state sampling programs. These and updated life history demographic data were integrated into a length-based numerical cohort model to generate LBRA fishery sustainability metrics from a probabilistic perspective. Three of five groupers, eight of eight snappers, and two of two grunts were below the 40% spawning potential ratio (SPR) stock sustainability minimum; ten of these stocks ...
Synthesis, Structural Characterization, And In Vitro Biological Assessment Of Trans- Platinum (Ii) Thionate Complexes As Potent Anticancer Agents,
2022
University of Arkansas, Fayetteville
Synthesis, Structural Characterization, And In Vitro Biological Assessment Of Trans- Platinum (Ii) Thionate Complexes As Potent Anticancer Agents, Mia Alshami
Chemistry & Biochemistry Undergraduate Honors Theses
The content of this thesis has been originally reported in our published paper, “trans-Platinum (II) Thionate Complexes: Synthesis, Structural Characterization, and in vitro Biological Assessment as Potent Anticancer Agents” ChemPlusChem 2019 84, 1525-1535, DOI: 10.1002/cplu.201900394, in which I served as coauthor. Cancer caused 9.6 million deaths in 2018 worldwide, with 18.1 million new diagnoses during that same year.The most widely used metal in anticancer drugs is platinum (Pt), and these drugs are used to treat almost 50% of cancer patients. To optimize drug effectiveness, trans-configured Pt(II) complexes have been introduced as ...
The Use Of Hallucinogens In The Treatment Of Mental Health Disorders,
2022
Murray State University
The Use Of Hallucinogens In The Treatment Of Mental Health Disorders, Brianna Gagen
Honors College Theses
The percent of people with mental health disorders in the United States have skyrocketed over the past decade. With stigma surrounding the discussion of mental health and the symptoms associated with it, often those that are suffering do not receive sufficient treatment, as they might with a physical illness. The current, common treatment options for common psychological disorders, like depression, anxiety, and post-traumatic stress disorder, are sometimes not effective in patients, due to resistance or poor response outcomes. Consequently, in order to research alternative therapeutic approaches for mental health disorders, scientists are researching the effects of several hallucinogenic drugs in ...
Initial Estuarine Response To Inorganic Nutrient Inputs From A Legacy Mining Facility Adjacent To Tampa Bay, Florida,
2022
Tampa Bay Estuary Program
Initial Estuarine Response To Inorganic Nutrient Inputs From A Legacy Mining Facility Adjacent To Tampa Bay, Florida, Marcus W. Beck, Andrew Altieri, Christine Angelini, Maya C. Burke, Jing Chen, Diana W. Chin, Jayne Gardiner, Chuanmin Hu, Katherine A. Hubbard, Yonggang Liu, Cary Lopez, Miles Medina, Elise Morrison, Edward J. Phlips, Gary E. Raulerson, Sheila Scolaro, Edward T. Sherwood, David Tomasko, Robert H. Weisberg, Joseph Whalen
Marine Science Faculty Publications
Legacy mining facilities pose significant risks to aquatic resources. From March 30th to April 9th, 2021, 814 million liters of phosphate mining wastewater and marine dredge water from the Piney Point facility were released into lower Tampa Bay (Florida, USA). This resulted in an estimated addition of 186 metric tons of total nitrogen, exceeding typical annual external nitrogen load estimates to lower Tampa Bay in a matter of days. An initial phytoplankton bloom (non-harmful diatoms) was first observed in April. Filamentous cyanobacteria blooms (Dapis spp.) peaked in June, followed by a bloom of the red tide organism Karenia brevis. Reported ...
A Biological Condition Gradient For Coral Reefs In The Us Caribbean Territories: Part I. Coral Narrative Rules,
2022
U.S. Environmental Protection Agency
A Biological Condition Gradient For Coral Reefs In The Us Caribbean Territories: Part I. Coral Narrative Rules, Deborah Santavy, Susan K. Jackson, Benjamin Jessup, Jeroen Gerritsen, Caroline Rogers, William S. Fisher, Ernesto Weil, Alina Szmant, David Cuevas-Miranda, Brian Walker, Christopher Jeffrey, Patricia Bradley, David Ballantine, Loretta Roberson, Hector Ruiz-Torres, Brandi Todd, Tyler Smith, Randy Clark, Ernesto Diaz, Jorge Bauzá-Ortega, Christina Horstmann, Sandy Raimondo
Marine & Environmental Sciences Faculty Articles
As coral reef condition and sustainability continue to decline worldwide, losses of critical habitat and their ecosystem services have generated an urgency to understand and communicate reef response to management actions, environmental contamination, and natural disasters. Increasingly, coral reef protection and restoration programs emphasize the need for robust assessment tools for protecting high-quality waters and establishing conservation goals. Of equal importance is the need to communicate assessment results to stakeholders, beneficiaries, and the public so that environmental consequences of decisions are understood. The Biological Condition (BCG) model provides a structure to evaluate the condition of a coral reef in increments ...
