Mitochondrial Roles In Developmentally Programmed Heart Disease,
2023
University of South Dakota
Mitochondrial Roles In Developmentally Programmed Heart Disease, Eli John Louwagie
Dissertations and Theses
Offspring of diabetic and obese mothers (ODOM) have greater risks of heart disease at birth and later in life. However, prevention is hindered because underlying mechanisms are poorly understood. Mounting studies in the Developmental Origins of Health and Disease field suggest that mitochondria play key roles in developmentally programmed heart disease similar to the roles they play in cardiomyopathy in adults with diabetes and obesity. However, whether mitochondria are responsible for the short[1]and long-term cardiac disease seen in ODOM remains unknown. Here, we sought to delineate the roles of mitochondria in the hearts of ODOM, determine whether mitochondria ...
Targeting The Cerebrovasculature In Sepsis: A Focus On The Brain Microvascular Endothelium,
2023
West Virginia University
Targeting The Cerebrovasculature In Sepsis: A Focus On The Brain Microvascular Endothelium, Divine C. Nwafor
Graduate Theses, Dissertations, and Problem Reports
The blood-brain barrier (BBB) is a critical interface between the systemic circulation and the brain. It is a specialized multicellular unit composed of brain microvascular endothelial cells (BMECs), pericytes, a basement membrane, and astrocytic end foot processes. BMECs are a principal component of the BBB that provide the structural framework needed for the stringent transport of molecules into the brain. BMEC dysfunction permits the trafficking of neurotoxins from systemic circulation into the brain, which ultimately exacerbates BBB dysfunction and neuroinflammation. Studies have shown that BBB dysfunction is a key determinant of cognitive decline in sepsis. However, there are critical knowledge ...
A Review On Nanomaterials And Nanohybrids Based Bio-Nanocomposites For Food Packaging,
2022
Technological University Dublin
A Review On Nanomaterials And Nanohybrids Based Bio-Nanocomposites For Food Packaging, Kalpani Y. Perera, Amit K. Jaiswal, Swarna Jaiswal
Articles
With an increasing demand for a novel, eco-friendly, high-performance packaging material “bio-nanocomposites” has attracted great attention in recent years. The review article aims at to evaluating recent innovation in bio-nanocomposites for food packaging applications. The current trends and research over the last three years of the various bio-nanocomposites including inorganic, organic nanomaterials, and nanohybrids, which are suitable as food packaging materials due to their advanced properties such as high mechanical, thermal, barrier, antimicrobial, and antioxidant are described in detail. In addition, the legislation, migration studies, and SWOT analysis on bio-nanocomposite film have been discussed. It has been observed that the ...
Wildfires Enhance Phytoplankton Production In Tropical Oceans,
2022
Edith Cowan University
Wildfires Enhance Phytoplankton Production In Tropical Oceans, Dongyan Liu, Chongran Zhou, John K. Keesing, Oscar Serrano, Axel Werner, Yin Fang, Yingjun Chen, Pere Masque, Janine Kinloch, Aleksey Sadekov, Yan Du
Research outputs 2022 to 2026
Wildfire magnitude and frequency have greatly escalated on a global scale. Wildfire products rich in biogenic elements can enter the ocean through atmospheric and river inputs, but their contribution to marine phytoplankton production is poorly understood. Here, using geochemical paleo-reconstructions, a century-long relationship between wildfire magnitude and marine phytoplankton production is established in a fire-prone region of Kimberley coast, Australia. A positive correlation is identified between wildfire and phytoplankton production on a decadal scale. The importance of wildfire on marine phytoplankton production is statistically higher than that of tropical cyclones and rainfall, when strong El Niño Southern Oscillation coincides with ...
Using Poultry To Enhance Food Security In Stann Creek, Belize,
2022
University of Arkansas, Fayetteville
Using Poultry To Enhance Food Security In Stann Creek, Belize, Emily Spatz
Poultry Science Undergraduate Honors Theses
Food insecurity is a growing issue in developing and developed countries alike, and in countries like Belize, the prevalence of hunger has soared in recent years. Not having access to diets with sufficient calories and nutrients leads to a host of developmental issues, including stunting and cognitive delays. The purpose of this work was to create an all-encompassing manual for small-scale broiler production, with the intention of another honors student overseeing the implementation of the ideas set forth in the manual, in order to provide nourishment for the students and staff of a school in Belize. After determining that the ...
Determining The Full-Length Structure Of Collagenase H Using Small-Angle X-Ray Scattering,
2022
University of Arkansas, Fayetteville
Determining The Full-Length Structure Of Collagenase H Using Small-Angle X-Ray Scattering, Josie Carson
Chemistry & Biochemistry Undergraduate Honors Theses
Known to cause gas gangrene, Hathewaya histolytica secretes two sister collagenases, collagenase G (Col G) and collagenase H (Col H), to degrade the triple helical structure of collagen to further infection in a host. Individual domains of Col H have been crystalized in previous studies, but methods in x-ray crystallization of full-length Col H have been unsuccessful. Using Small Angle X-Ray Scattering (SAXS) data, atomistic modeling was used to generate multiple conformations of Col H while accounting for flexibility between domains. Full-length Col H was found to adopt a two-state conformational model exhibiting a majority compact and a minority elongated ...
Mirnas Levels In A Streptozocin Model Of Alzheimer’S Disease,
2022
American University in Cairo
Mirnas Levels In A Streptozocin Model Of Alzheimer’S Disease, Nada Moustafa
Theses and Dissertations
Dementia entails a progressive decrease in cognitive functions, with 50%-75% of cases attributed to Alzheimer’s disease (AD); an aging-associated condition characterized by the build-up of tangled phosphorylated Tau (p-Tau) protein and beta-amyloid (Aβ) depositions. Sporadic AD (sAD) is multifactorial in nature, resulting from a combination of environmental and genetic predisposing factors. Type 2 diabetes mellitus (T2DM) is a leading risk factor for dementia, and deregulation of brain glucose metabolism is associated with early cognitive affection in sAD. Thus, the diabetogenic agent Streptozotocin (STZ) is used to experimentally create an AD model in animals (STZ-induced sAD), in which abnormalities ...
Utility Of The Motivation To Change Lifestyle And Health Behaviors For Dementia Risk Reduction Scale (Mclhb-Drr) Based On A North American Sample,
2022
National Louis University
Utility Of The Motivation To Change Lifestyle And Health Behaviors For Dementia Risk Reduction Scale (Mclhb-Drr) Based On A North American Sample, Angelina E. Witbeck
Dissertations
As the population ages, the prevalence rates of dementia continue to increase. Without a cure or promising treatment for dementia, the best course of lowering the prevalence rates of dementia is through preventative measures. Through an electronic survey, the study utilized the MCLHB-DRR scale to determine whether (1) gender, age, educational background, and socioeconomic status will impact the motivational factors to change lifestyle and health behaviors to reduce the risk of developing dementia and (2) direct experiences with individuals that have a dementia diagnosis are likely to impact one's motivational factors to change lifestyle and health behaviors to reduce ...
A Cross-Country Investigation Of Social Image Motivation And Acceptance Of Lab-Grown Meat In Singapore And The United States,
2022
Singapore Management University
A Cross-Country Investigation Of Social Image Motivation And Acceptance Of Lab-Grown Meat In Singapore And The United States, Mark Chong, Angela K. Y. Leung, Verity Lua
Research Collection Lee Kong Chian School Of Business
This research has three goals. First, it sets out to compare consumer acceptance of lab-grown meat in the U.S. and in Singapore. Second, it seeks to explain the difference in Americans' and Singaporeans' acceptance of lab-grown meat by examining their eating motivations. Specifically, we focused on social image motivations – the motivations to present oneself positively in social contexts. Third, this study also aims to assess if exposure to information about lab-grown meat communicated by celebrity versus expert social media influencers (SMIs) can impact people's acceptance of lab-grown meat products. Our analysis showed that Singaporean participants had greater acceptance ...
The Impact Of Focused Attention And Opening Monitoring Meditation Styles On Attention,
2022
The Graduate Center, City University of New York
The Impact Of Focused Attention And Opening Monitoring Meditation Styles On Attention, Jennifer Wheary
Dissertations, Theses, and Capstone Projects
Mindfulness meditation – often broken down into two distinct types, focused attention (FA) and open monitoring (OM) – has been associated with a range of affective and attentional benefits. Using an attentional blink (AB) paradigm that demonstrated improved attention for novice FA meditators, we explored whether novices who engaged in a single, brief bout of meditation exhibited any differences in alpha or theta power during meditation, and whether these differences were apparent by meditation type. In the AB paradigm, participants are asked to identify two targets, T1 and T2, which are separated by 200-500 ms. Our results showed no significant differences between ...
Cdc6 Is Sequentially Regulated By Pp2a-Cdc55, Cdc14, And Sic1 For Origin Licensing In S. Cerevisiae,
2022
The Graduate Center, City University of New York
Cdc6 Is Sequentially Regulated By Pp2a-Cdc55, Cdc14, And Sic1 For Origin Licensing In S. Cerevisiae, Jasmin Philip
Dissertations, Theses, and Capstone Projects
Control of DNA replication is critical for progression of the cell cycle and genomic stability. Cyclin-dependent kinases (CDKs) coordinate numerous phosphorylation events to accomplish two biological tasks for all living organisms: DNA replication and cell division. One CDK, Cyclin-Cdc28, is responsible for cell cycle progression in budding yeast. DNA replication requires a stepwise assembly of the pre-replicative complex on DNA, including Orc1-6, Cdc6, Cdt1 and Mcm2-7, during M-G1 phase. Cdc6 contains eight Cdc28 consensus sites, SP or TP motifs. Clb5-Cdc28 phosphorylates Cdc6-T7 to recruit Cks1, the Cdc28 phospho-adaptor, for subsequent multisite phosphorylation during S phase. There are two phospho-degrons at ...
Robert Rosen And Relational System Theory: An Overview,
2022
The Graduate Center, City University of New York
Robert Rosen And Relational System Theory: An Overview, James Lennox
Dissertations, Theses, and Capstone Projects
Relational system theory is the science of organization and function. It is the study of how systems are organized which is based on their functions and the relations between their functions. The science was originally developed by Nicolas Rashevsky, and further developed by Rashevsky’s student Robert Rosen, and continues to be developed by Rosen’s student A. H. Louie amongst others. Due to its revolutionary character, it is often misunderstood, and to some, controversial. We will mainly be focusing on Rosen’s contributions to this science. The formal and conceptual setting for Rosen’s relational system theory is category ...
Elucidating Mechanisms Of Biofluorescence And Bioluminescence In Marine Organisms,
2022
The Graduate Center, City University of New York
Elucidating Mechanisms Of Biofluorescence And Bioluminescence In Marine Organisms, Andrew M. Guarnaccia
Dissertations, Theses, and Capstone Projects
Biofluorescence and bioluminescence are two methods of light emission that entail separate mechanisms of action but end at the same process: a colorful display that have tremendous ecological and behavioral benefits, whether it be used to communicate with conspecifics, camouflage into a multicolored background, attract unsuspecting prey, or alert others to a predator. In biofluorescence, higher-energy, shorter wavelength light is absorbed then re-emitted as lower-energy, longer-wavelength light. Bioluminescence on the other hand entails a chemical reaction in which a small molecule is oxidized by an enzyme, creating a high-energy intermediate that sheds the excess energy in the form of visible ...
The Neurobiology Of The Healing Arts: Expressive Arts Therapy As An Effective Treatment For Adults Diagnosed With Complex Ptsd Due To Complex Trauma In Childhood: A Literature Review,
2022
Lesley University
The Neurobiology Of The Healing Arts: Expressive Arts Therapy As An Effective Treatment For Adults Diagnosed With Complex Ptsd Due To Complex Trauma In Childhood: A Literature Review, Cheryl Ratliff
Expressive Therapies Capstone Theses
Empirically based therapies for posttraumatic stress disorder (PTSD) have been found to be less effective in treating more severe trauma presentations such as complex PTSD (CPTSD). Neurobiological investigation provides a framework for examining the physical and psychological effects of trauma on brain and nerve structures and provides insight into how to effectively treat CPTSD. This literature review examined symptomology of CPTSD resulting from complex trauma in childhood, neurobiological effects of trauma and their implications for treatment, and the efficacy of the current treatment models, primarily those of eye movement desensitization and reprocessing (EMDR), narrative exposure therapy (NET), and somatic psychotherapies ...
Boxed Lunches,
2022
Virginia Commonwealth University
Boxed Lunches, Lunch
Biology and Medicine Through Mathematics Conference
No abstract provided.
Mathematics Of A Single-Locus Model For Assessing The Impacts Of Pyrethroid Resistance And Temperature On Population Abundance Of Malaria Mosquitoes,
2022
Morgan State University
Mathematics Of A Single-Locus Model For Assessing The Impacts Of Pyrethroid Resistance And Temperature On Population Abundance Of Malaria Mosquitoes, Jemal Mohammed-Awel
Biology and Medicine Through Mathematics Conference
No abstract provided.
Mixed Mode Oscillations In Three-Timescale Coupled Morris-Lecar Neurons,
2022
University of Iowa
Mixed Mode Oscillations In Three-Timescale Coupled Morris-Lecar Neurons, Ngocanh Phan, Yangyang Wang
Biology and Medicine Through Mathematics Conference
No abstract provided.
Modeling The Cardiovascular Dynamics Of Postural Orthostatic Tachycardia Syndrome,
2022
North Carolina State University at Raleigh
Modeling The Cardiovascular Dynamics Of Postural Orthostatic Tachycardia Syndrome, Justen Geddes
Biology and Medicine Through Mathematics Conference
No abstract provided.
Modeling Acute And Chronic Vascular Adaptations To A Major Arterial Occlusion,
2022
Indiana University Purdue University Indianapolis
Modeling Acute And Chronic Vascular Adaptations To A Major Arterial Occlusion, Erin O. Zhao
Biology and Medicine Through Mathematics Conference
No abstract provided.
Mathematical Model Of Subthalamic Nucleus Neuron - Characteristic Activity Patterns And Bifurcation Analysis,
2022
North Carolina Agricultural and Technical State University
Mathematical Model Of Subthalamic Nucleus Neuron - Characteristic Activity Patterns And Bifurcation Analysis, Choongseok Park, Sungwoo Ahn, Leonid Rubchinsky
Biology and Medicine Through Mathematics Conference
No abstract provided.
