Life Sciences Commons^™

The Effects Of Sr2w-1 Supplementation On Cycling Performance And Muscle Fatigue, Tara Ali Ata

Masters Theses, 2010-2019

The purpose of this investigation was to examine the potential effects of SR2W-1 supplementation on cycling performance, central fatigue, and a variety of physiological parameters, including blood lactate, blood pH, heart rate (HR), rating of perceived exertion (RPE), oxygen consumption (VO2), expired ventilation (VE), and respiratory exchange ratio (RER). Methods: Five recreational cyclists (38 ± 8 yr, 168.4 ± 4.3 cm, 68.8 ± 5.6 kg, and 54.4 ± 2.6 mL/kg/min) performed 20-min of steady-state cycling (~85% VO2max) followed by three 1-min high intensity intervals at VO2max with 30-sec active recovery periods at 100 W, 15-min passive recovery period, and a …

The Genetic Influence On The Placebo Effect Specific To Exercise Performance, Jennifer Wu

Masters Theses, 2010-2019

Placebo treatments can be used to elicit many different physiological responses; however, the underlying mechanisms responsible remain unclear. Recent research has shown the possibility of a genetic influence on the placebo response in patients with mood disorders. In this study, we attempted to establish a similar relationship in healthy college-aged students. Force production was measured by isometric knee extension of the quadriceps muscles using maximum voluntary contractions (MVC). Subjects were given placebo treatments disguised as an undisclosed sports supplement with the information that the supplement was previously shown to provide immediate strength improvements following ingestion. Subject DNA was genotyped for …

Macy, Jethro (Sc 223), Manuscripts & Folklife Archives

MSS Finding Aids

Finding aid only for Manuscripts Small Collection 223. Copy of portion of a diary kept by Macy from 8 November 1847 to 2 November 1848 chiefly while residing with the Shakers at South Union, Kentucky. He engaged in carpentry work and tending cattle before moving to Newburgh, Indiana, 25 July 1848. Includes 1961 letter related to the diary.

Concurrent Aerobic Exercise Interferes With The Satellite Cell Response To Acute Resistance Exercise In Mhc I Muscle Fibers, Lyle W. Babcock

Masters Theses, 2010-2019

Purpose: Concurrent training attenuates hypertrophy compared to resistance training alone, and does so in a fiber-type specific manner. The mechanism responsible for this ‘interference’ is unclear, and satellite cell physiology, an important hypertrophic factor, has not been examined within this context. Therefore, the purpose of this investigation was to assess the fiber-type specific satellite cell response to acute resistance, aerobic and concurrent exercise. Methods: Eight recreationally active college-aged males (23±1 yrs, 83.4±3.6 kg, 181±2 cm, and 48.5±1.6 ml/kg/min) performed 3 sets of 10 repetitions with a fourth set ≥ 10 repetitions at 75% of 1RM for both unilateral leg extensions …

Spatial And Temporal Diffusion Of Agricultural Best Management Practice Adoption In The South Fork Shenandoah River Watershed., Megan Renee Bauer

Masters Theses, 2010-2019

This research visualizes, describes, and analyzes the unique spatial and temporal diffusion of agricultural best management practices adopted within the South Fork Shenandoah River Watershed during the twenty year period from 1989 to 2008. The Shenandoah River is a tributary of the Potomac River, which in turn flows directly into the Chesapeake Bay. The findings and research presented here could aid policy makers, conservation technicians, and Soil and Water Conservation District agents to better plan promotions and funding for cost share BMPs. This research identifies motivations and influential forces that are inherent in the BMPs, in the social system, and …

A Poultry All-Hazard Threat, Vulnerability, And Capability Assessment With Rockingham County Fire Rescue., Daniel Robert Dales

Masters Theses, 2010-2019

Agriculture is argued to be one of our most critical infrastructures and is vital to human health and survivability. Agriculture is economically important in Virginia as it provides over 350,000 jobs and generates $55 billion annually (Virginia Department of Agriculture and Consumer Services). This high criticality lends to significant areas of vulnerability in each sector of agriculture. Rockingham County is of particular importance as the top agriculturally producing county in the state and is ranked 5th in the nation for poultry sales (2007 Census of Agriculture). The desire to uphold this high production calls for a need to better understand …

Effect Of Diet Induced Weight Loss And Exercise On Hscreactive Protein In Sedentary Postmenopausal Women, Jennifer Donnelly

Masters Theses, 2010-2019

Cardiovascular disease (CVD) risk factors, such as increased body fat, dyslipidemia, and high sensitivity C-reactive protein (CRP) levels are intensified in postmenopausal women. CRP has been reported as an independent indicator of risk for cardiovascular events. CRP is affected by multiple factors such as age, race, body mass index (BMI), and physical activity level. The purpose of this study was to compare the effects of an exercise intervention on traditional (BMI, percent body fat, waist circumference, physical activity level) and non-traditional (CRP) risk factors for cardiovascular disease to a dietary intervention program in sedentary, postmenopausal women. Twenty apparently healthy postmenopausal …

Variation In The Branching Pattern Of The Four Major Caudal Vessels Emerging From The External Carotid Artery, Sara B. Heltzel

Masters Theses, 2010-2019

The branching pattern of vessels emerging from the external carotid artery (ECA) displays considerable variation. Knowledge of this variation is of particular interest to clinicians. There are few reports in the literature assessing these differences with regard to sex and sidedness (i.e., branching patterns of the right vs. left neck). The objective of this study was to assess the origin of the four primary caudal branches of the external carotid artery: the superior thyroid (STA), lingual (LA), facial (FA), and occipital (OA) arteries, in addition to the level of common carotid artery bifurcation (CB), with regard to sex, and side. …

Interleukin-3 Promotes Susceptibility In A Mouse Model Of Cutaneous Leishmaniasis, Bryan Lewis Saunders

Masters Theses, 2010-2019

Cutaneous leishmaniasis (CL), a vector-borne infectious disease caused by protozoan parasites of the genus Leishmania, is one of the most important neglected infectious diseases worldwide. Currently, 10 million people in 82 (mostly developing) countries are infected. Those infected develop ulcerative skin lesions on exposed parts of the body, causing serious disability and permanent scarring. All mice are susceptible to infection with Leishmania major, however, the outcome of infection is different depending on the mouse strain. For example, resistant C57BL/6 mice develop lesions, which like in humans, ultimately heal. In contrast, lesions in susceptible BALB/c mice progressively worsen, ultimately resulting in …

Influence Of Estradiol And Exercise On Foot Laxity, Ankle Laxity, And Plantar Loading In College Athletes, Kristina Teri Silke

Masters Theses, 2010-2019

As female participation in athletics has increased, it has become apparent that sex differences exist in sports-related injury types and frequencies. The purpose of this study is to examine the effects of exercise and the sex hormone estradiol on sex differences in foot and ankle laxity and plantar pressure. We measured serum estradiol, pre- and post-fatigue ankle and toe laxity, and pre- and post-fatigue plantar pressure in 47 subjects (34 female, 13 male) once a week for 12 weeks. We compared laxity and plantar pressure in females not using oral contraceptive (NOC) to females using oral contraceptives (OC) and males. …

A Taxonomic Revision Of The Endemic Members Of Varronia P. Br. (Cordiaceae) In The Galápagos Islands, Julia Kathryn Stutzman

Masters Theses, 2010-2019

The Galápagos Islands have long been an arena for biological diversity, scientific discovery, and conservation. Accurate identification and documentation of the flora of the Galápagos continue to aid conservation efforts. The purpose of this study was to conduct a taxonomic revision of the endemic members genus Varronia (Cordiaceae) on the Islands: V. revoluta (Hook. f.) Andersson, V. leucophlyctis (Hook. f.) Andersson, V. canescens Andersson, and V. scouleri (Hook. f.) Andersson. Taxonomic uncertainty among these species has resulted in difficult evaluation of their potential for conservation status by the International Union for the Conservation of Nature. The present taxonomic study concludes …

Ontogeny Of Postcranial Morphology And Locomotor Behavior In Propithecus Verreauxi Coquereli And Lemur Catta, Stephanie Ann Wolf

Masters Theses, 2010-2019

Despite living under the same environmental pressures and sympatrically in many cases, Propithecus verreauxi and Lemur catta have evolved very different strategies for survival in stochastic environmental conditions. P. verreauxi show slow somatic growth, low maternal investment, and rapid dental growth while L. catta show faster somatic growth, high maternal investment, and slower dental growth. P. v. coquereli are highly specialized for vertical clinging and leaping (VCL) among lemurs, while L. catta, the most terrestrial of lemurs, use a wider variety of locomotor types including quadrupedalism, climbing, and leaping. P. v. coquereli have unusually long legs and muscular thighs while …

Alteration Of Forest Structure Modifies The Distribution Of Scale Insect, Stigmacoccus Garmilleri, In Mexican Tropical Montane Cloud Forests, Heather A. Gamper, Suzanne Koptur, Jose García-Franco, Andres Plata Stapper

Department of Biological Sciences

Stigmacoccus garmilleri Foldi (Hemiptera: Margarodidae) is an ecologically important honeydew-producing scale insect associated with oak trees (Quercus spp.) in highland forests of Veracruz, Mexico. The honeydew exudates of S. garmilleri serve as a significant nutrient source to many species of birds, insects, and sooty molds. Oak trees found in the forest interior, forest edge, and those scattered in pasture areas support scale insect colonies, though the pattern of insect infestations on trees within these varying landscape types has not been elucidated. This study aims to describe the distribution of scale insect infestation and any distinctions in honeydew production based …

Public Health Finance Management Needs And How Public Health Agencies Are Funded., F. Douglas Scutchfield Md

Preventive Medicine and Environmental Health Presentations

No abstract provided.

Phylogenetics And Diversification Of Escallonia (Escalloniaceae), Felipe Zapata

Dissertations

Despite a large accumulation of evidence on the high richness of plant species in the mountains of South America, little is known about the historical underpinnings of this diversity. To contribute to our understanding of the origin and diversification of plant species in these mountains, I analyzed geographic patterns of variation in molecular and phenotypic characters for the genus Escallonia L.f. (Escalloniaceae), a group of shrubs widespread in montane habitats in South America. Molecular phylogenetic analyses using chloroplast and nuclear loci revealed i) that Escallonia is monophyletic, ii) a remarkable level of geographical phylogenetic structure, and iii) a widespread absence …

W270 Safety Of Herbicides Compared To Other Commonly Used Chemicals Pub Number W270, Greg Breeden, James T. Brosnan, Greg Armel, Joseph Thomas

Commercial Horticulture

Turfgrass Science factsheet

Version 2.0

Mechanistic Study Of The Small Molecule Inhibitor Dx-52-1, Junru Cui

Master's Theses

Cell migration is a basic biological process that is fundamental to several normal and disease processes such as embryonic development, tissue repair, immune function, angiogenesis and cancer cell invasion and metastasis. Small organic molecules inhibiting cell migration can be used as both research probes and therapeutic agents. DX-52-1, a semisynthetic derivative of the natural product quinocarmycin (also known as quinocarcin), inhibits the migration of Madin-Darby canine kidney epithelial cells with nanomolar concentration. We have identified galectin-3, a multifunctional protein whose best-known function is its sugar binding ability, as a secondary target of DX-52-1 with functions in cell motility. In addition, …

Public Health Finance Management Needs And How Public Health Agencies Are Funded., F. Douglas Scutchfield Md

F. Douglas Scutchfield MD

No abstract provided.

A New Species Of Vaejovis From Prescott, Arizona (Scorpiones: Vaejovidae), Richard F. Ayrey, Michael E. Soleglad

Euscorpius

A new scorpion species, Vaejovis crumpi, sp. nov., is described from Prescott, Yavapai Co., Arizona. This species is related to V. paysonensis Soleglad, 1973, and the “sky island” species of southern Arizona. V. crumpi is compared to the seven Vaejovis species currently reported for Arizona, in particular to V. paysonensis.

A Review Of Literature For Osteology: Cell Biology, Tissue Biology, And The Application Of Synthetic Compounds For The Facilitation Of Bone Tissue Repair, Ryan T. Jones

Honors Theses

Bone is a dynamic matter that provides support, structure, mineral reserves, and stem cell reserves for the body. Important functions range from structural support for the body to roles in maintaining homeostasis. Structure and support for the body is the most obvious role, with the skeletal system as a whole providing a normal force for other tissues and organs to resist gravity. Protection is also inferred for tissues and organs from impacting forces, especially with axial bones covering vital organs in the thoracic cavity. Another function of bone includes the ability to store and release minerals when needed to maintain …

Upper Pleistocene Human Dispersals Out Of Africa: A Review Of The Current State Of The Debate, Amanuel Beyin

Faculty Scholarship

Although there is a general consensus on African origin of early modern humans, there is disagreement about how and when they dispersed to Eurasia. This paper reviews genetic and Middle Stone Age/Middle Paleolithic archaeological literature from northeast Africa, Arabia, and the Levant to assess the timing and geographic backgrounds of Upper Pleistocene human colonization of Eurasia. At the center of the discussion lies the question of whether eastern Africa alone was the source of Upper Pleistocene human dispersals into Eurasia or were there other loci of human expansions outside of Africa? The reviewed literature hints at two modes of early …

Analysis Of Nfi-X3 And Stat3 Interaction And Its Functions, Etsegenet Tizazu

Theses and Dissertations

YKL-40 is a secreted protein that is highly up-regulated in malignant glioblastoma (GBM). Its expression is correlated with the invasive nature of GBMs and poor diagnosis of patients (Nigro et al., 2005). Previous research has shown that in astrocytes and GBM cells, YKL-40 expression is regulated by two transcription factors, NFI-X3 and STAT3, which form a complex with each other (Singh et al., 2011). Here, we show that the N-terminal domain of NFI-X3 is sufficient and required for its interaction with STAT3. We also show that the DNA-binding domain of NFI-X3 is required to induce YKL-40 expression. Thus, the interaction …

Septin Filaments Exhibit A Dynamic, Paired Organization That Is Conserved From Yeast To Mammals, Bradley S. Demay, Xiaobo Bai, Louisa Howard, Patricia Occhipinti, Rebecca A. Meseroll, Elias T. Spiliotis, Rudolf Oldenbourg, Amy S. Gladfelter

Dartmouth Scholarship

The septins are conserved, GTP-binding proteins important for cytokinesis, membrane compartmentalization, and exocytosis. However, it is unknown how septins are arranged within higher-order structures in cells. To determine the organization of septins in live cells, we developed a polarized fluorescence microscopy system to monitor the orientation of GFP dipole moments with high spatial and temporal resolution. When GFP was fused to septins, the arrangement of GFP dipoles reflected the underlying septin organization. We demonstrated in a filamentous fungus, a budding yeast, and a mammalian epithelial cell line that septin proteins were organized in an identical highly ordered fashion. Fluorescence anisotropy …

Synaptic Reorganization Of Inhibitory Hilar Interneuron Circuitry After Traumatic Brain Injury In Mice, Robert F. Hunt, Stephen W. Scheff, Bret N. Smith

Physiology Faculty Publications

Functional plasticity of synaptic networks in the dentate gyrus has been implicated in the development of posttraumatic epilepsy and in cognitive dysfunction after traumatic brain injury, but little is known about potentially pathogenic changes in inhibitory circuits. We examined synaptic inhibition of dentate granule cells and excitability of surviving GABAergic hilar interneurons 8–13 weeks after cortical contusion brain injury in transgenic mice that express enhanced green fluorescent protein in a subpopulation of inhibitory neurons. Whole-cell voltage-clamp recordings in granule cells revealed a reduction in spontaneous and miniature IPSC frequency after head injury; no concurrent change in paired-pulse ratio was found …

Effectiveness Of Social Media Marketing: An Experimental Inquiry On College Students’ Awareness Of, Interest In, And Intention To Participate In A Campus Recreation Special Event, Kendra S. Bayne

Kinesiology Theses

This study examined the effectiveness of social media marketing on college students attending a recreation special event. Facebook and Twitter were assessed via an experimental design. To measure the effectiveness of these applications (through updating statuses) on a college student’s awareness, interest, and intent of attending a special event, three groups were employed (Facebook, Twitter, and Control). A total of 134 participants were recruited via six undergraduate courses and were assigned into three groups based on their social media consumption. Subjects responded to a pre-survey, joined their respective treatment group, and completed a post-survey. Descriptive statistics revealed that awareness increased …

The Corporate Agenda For Environmental Property Rights, Sharon Beder

Sharon Beder

Market and property-rights based approaches to environmental problems have been heavily promoted by conservative think tanks. Consequently policies such as emissions trading, water markets, tradeable fishing quotas and conservation banking pervade environmental policy in English speaking nations. They have enabled the corporate neo-liberal agenda of deregulation, privatisation and an unconstrained market to be dressed up as an environmental virtue. This market-faith based approach is proving to be largely ineffective at protecting the environment and also inequitable.

Market Mechanisms, Ecological Sustainability And Social Equity, Sharon Beder

Sharon Beder

In most cases the use of market mechanisms to protect the environment aim to maximise economic efficiency rather than environmental effectiveness or equity. The use of emissions trading to reduce greenhouse gases in the atmosphere is used as a case study to demonstrate this.

Effects Of Management On Double-Crested Cormorant Nesting Colony Fidelity, Bronson K. Strickland, Brian S. Dorr, Fred Pogmore, Gary Nohrenberg, Scott C. Barras, John E. Mcconnell, John Gobeille

Brian S Dorr

No abstract provided.

Antimicrobial And Antioxidant Activities Of Essential Oil And Methanol Extract Of Matricaria Chamomilla L. From Djibouti, Fatouma M. Abdoul-Latif, Mohamed Nabil, Prosper Edou, Adwa A. Ali, Samatar O. Djama, Louis-Clément Obamé, Mamoudou H. Dicko Prof.

Pr. Mamoudou H. DICKO, PhD

The essential oil and methanol extracts of Matricaria Chamomilla L. were subjected to screening for their possible antioxidant activity by two complementary test systems, namely 2,2-diphenykpicrylhydrazyl (DPPH) free radical scavenging and β-carotene-linoleic acid assays. BHT was used as positive control in both test systems. In the DPPH test system, the IC50 values of essential oil and methanol extracts were 4.18 and 1.83 μg/ml, respectively. In the β-carotene-linoleic acid system, oxidation was effectively inhibited by M. Chamomilla, the RAA value of essential oil and methanol extracts were 12.69 and 11.37 %, respectively. When compared to BHT, the essential oil and methanol …

Muc4 Modulation Of Ligand-Independent Erbb2 Signaling, Goldi Attias Kozloski

Goldi A Kozloski

The membrane mucin Muc4 is a heterodimer, bi-functional glycoprotein complex that is normally expressed in epithelial tissue. Functional studies on the extracellular mucin subunit of Muc4 have shown that it acts to promote anti-adhesion properties by sterically interfering with cell-cell and cell-matrix interactions and that the extent of this effect is directly associated with the number of tandem repeats on this subunit. Functional studies on the transmembrane subunit of Muc4 have shown that this subunit participates in intracellular signaling through interaction with the receptor tyrosine kinase ErbB2. This role of Muc4 was shown to be mediated by stabilizing the heregulin …