Physical Sciences and Mathematics Commons^™

Tuning Protein Dynamics To Sense Rapid Endoplasmic-Reticulum Calcium Dynamics, Xiaonan Deng, Xin-Qiu Joe Yao, Ken Berglund, Bin Dong, Daniel Ouedraogo, Mohammad A. Ghane, You Zhuo, Cheyenne Mcbean, Zheng Zachory Wei, Samer Gozem, Shan P. Yu, Ling Wei, Ning Fang, Angela M. Mabb, Giovanni Gadda, Donald Hamelberg, Jenny J. Yang

Chemistry Faculty Publications

Multi-scale calcium (Ca2+) dynamics, exhibiting wide-ranging temporal kinetics, constitutes a ubiquitous mode of signal transduction. We report a novel endoplasmic-reticulum (ER)-targeted Ca2+ indicator, R-CatchER, which showed superior kinetics in vitro (koff≥2×103 s−1, kon≥7×106 M−1 s−1) and in multiple cell types. R-CatchER captured spatiotemporal ER Ca2+ dynamics in neurons and hotspots at dendritic branchpoints, enabled the first report of ER Ca2+ oscillations mediated by calcium sensing receptors (CaSRs), and revealed ER Ca2+-based functional cooperativity of CaSR. We elucidate the mechanism of R-CatchER and propose a principle to rationally design genetically encoded Ca2+ indicators with a single Ca2+-binding site …

A Randomized Controlled Trial To Determine Whether Beta-Hydroxy-Beta-Methylbutyrate And/Or Eicosapentaenoic Acid Improves Diaphragm And Quadriceps Strength In Critically Ill Mechanically Ventilated Patients, Gerald S. Supinski, Paul F. Netzel, Philip M. Westgate, Elizabeth A. Schroder, Lin Wang, Leigh Ann Callahan

Internal Medicine Faculty Publications

BACKGROUND: Intensive care unit acquired weakness is a serious problem, contributing to respiratory failure and reductions in ambulation. Currently, there is no pharmacological therapy for this condition. Studies indicate, however, that both beta-hydroxy-beta-methylbutyrate (HMB) and eicosapentaenoic acid (EPA) increase muscle function in patients with cancer and in older adults. The purpose of this study was to determine whether HMB and/or EPA administration would increase diaphragm and quadriceps strength in mechanically ventilated patients.

METHODS: Studies were performed on 83 mechanically ventilated patients who were recruited from the Medical Intensive Care Units at the University of Kentucky. Diaphragm strength was assessed as …

Research On Supply And Demand Of Container Port Handling Capacity—Taking Yangshan Harbor Area Of Shanghai Port As An Example, Liangxi Chen

World Maritime University Dissertations

No abstract provided.

Research On Port Call Processes To Enable Just-In-Time Arrival Based On Container Shipping Case Study In The Port Of Shanghai, Yang Chen

World Maritime University Dissertations

No abstract provided.

Research On Multimodal Transport Documents Under One Belt One Road, Wenshuo Cui

World Maritime University Dissertations

No abstract provided.

The Effect Of New Western Land-Sea Corridor On Ports In East China (A Case Study Of Shanghai Port), Yixin Liu

World Maritime University Dissertations

No abstract provided.

The Formation Mechanism Of China's Export Container Freight Rate, Yuchao Liu

World Maritime University Dissertations

No abstract provided.

Research On The International Linkage Of Chinese Oil Tanker Transport Market Based On The Theory Of New Economic Geospatial, Cheng Miao

World Maritime University Dissertations

No abstract provided.

Research On Optimization Of A Company's Agricultural Products Cold Chain Logistics System, Shizhe Qiao

World Maritime University Dissertations

No abstract provided.

Research On Responses Of Container Ports To Global Pandemic, Yirui Qiao

World Maritime University Dissertations

No abstract provided.

Analysis On The Fluctuation Of China's Imported Iron Ore Freight Rate In Recent, Yizheng Shen

World Maritime University Dissertations

No abstract provided.

Digitalization In The Port Industry From The Perspectives Of Bibliometric Analysis, Xuyuan Sun

World Maritime University Dissertations

No abstract provided.

Forecasting The Recovery Of The International Container Shipping Market In The Presence Of Covid-19, Tengrongre Wang

World Maritime University Dissertations

No abstract provided.

Comparison Of Port Climate Change Adaptation Strategy And Climate Change Mitigation Strategy Based On The Case Study Of Shanghai Port, Jingjie Xia

World Maritime University Dissertations

No abstract provided.

Research On Shanghai Export Container Freight Index Fluctuation Based On Arma-Garch-X Model, Weihang Xu

World Maritime University Dissertations

No abstract provided.

Analysis Of The Influence Of Beibu Gulf Port Development On Regional Economy, Hanyue Zhang

World Maritime University Dissertations

No abstract provided.

Reaserch On Optimal Timing Of Vessel Investment The Introduction Of Ccdg Method, Qianfang Zhang

World Maritime University Dissertations

No abstract provided.

Cap-And-Trade Or Subsidy? Governments’ Policy Selection On Emission Reduction For Maritime Industry, Wen Zhang

World Maritime University Dissertations

No abstract provided.

Investment Value Analysis Of China's Participation In Port Projects Along The 21st Century Maritime, Xin Zhang

World Maritime University Dissertations

No abstract provided.

The Management System Of Novcc In China And Its Improvement, Zixuan Zhang

World Maritime University Dissertations

No abstract provided.

Study On Amalgamation Of The Logistics Industry And Manufacturing Industry — Shanghai’S Case Study, Haole Zheng

World Maritime University Dissertations

No abstract provided.

Research On The Development Of Shipping Alliance, Xudong Zhao

World Maritime University Dissertations

No abstract provided.

Solar Cycle-Modulated Deformation Of The Earth–Ionosphere Cavity, Tamás Bozóki, Gabriella Sátori, Earle Williams, Irina Mironova, Péter Steinbach, Emma C. Bland, Alexander Koloskov, Yuri M. Yampolski, Oleg V. Budanov, Mariusz Neska, Ashwini K. Sinha, Rahul Rawat, Mitsuteru Sato, Ciaran D. Beggan, Sergio Toledo-Redondo, Yakun Liu, Robert Boldi

All Works

The Earth–ionosphere cavity resonator is occupied primarily by the electromagnetic radiation of lightning below 100 Hz. The phenomenon is known as Schumann resonances (SR). SR intensity is an excellent indicator of lightning activity and its distribution on global scales. However, long-term measurements from high latitude SR stations revealed a pronounced in-phase solar cycle modulation of SR intensity seemingly contradicting optical observations of lightning from satellite, which do not show any significant solar cycle variation in the intensity and spatial distribution of lightning activity on the global scale. The solar cycle-modulated local deformation of the Earth–ionosphere cavity by the ionization of …

Vacancy Control In Acene Blends Links Exothermic Singlet Fission To Coherence, Clemens Zeiser, Chad Cruz, David R. Reichman, Michael Seitz, Jan Hagenlocher, Eric L. Chronister, Christopher J. Bardeen, Roel Tempelaar, Katharina Broch

Chemistry and Biochemistry Faculty Research

The fission of singlet excitons into triplet pairs in organic materials holds great technological promise, but the rational application of this phenomenon is hampered by a lack of understanding of its complex photophysics. Here, we use the controlled introduction of vacancies by means of spacer molecules in tetracene and pentacene thin films as a tuning parameter complementing experimental observables to identify the operating principles of different singlet fission pathways. Time-resolved spectroscopic measurements in combination with microscopic modelling enables us to demonstrate distinct scenarios, resulting from different singlet-to-triplet pair energy alignments. For pentacene, where fission is exothermic, coherent mixing between the …

Singlet Fission In Acene Blends, Katharina Broch, Clemens Zeiser, Chad Cruz, Luca Moretti, Margherita Maiuri, Eric Chronister, David Reichman, Roel Tempelaar, Giulio Cerullo, Christopher Bardeen

Chemistry and Biochemistry Faculty Research

Singlet fission (SF), the photophysical process converting an excited singlet exciton into two triplet excitons, is a promising approach to boost solar cell efficiencies. It is controlled by various parameters such as intermolecular interactions, energetics, entropy and vibronic coupling and a controlled modification of these parameters is key to a fundamental understanding. Blends of organic semiconductors present an interesting alternative to established methods of chemical functionalization and their potential for the study of SF pathways will be discussed using acene blends as example. Mixed thin films of SF chromophores and weakly interacting, high-bandgap spacer molecules allow one to study the …

Controllable Co2 Electrocatalytic Reduction Via Ferroelectric Switching On Single Atom Anchored In2se3 Monolayer, Lin Ju, Xin Tan, Xin Mao, Yuantong Gu, Sean Smith, Aijun Du, Zhongfang Chen, Changfeng Chen, Liangzhi Kou

Physics & Astronomy Faculty Research

Efficient and selective CO2 electroreduction into chemical fuels promises to alleviate environmental pollution and energy crisis, but it relies on catalysts with controllable product selectivity and reaction path. Here, by means of first-principles calculations, we identify six ferroelectric catalysts comprising transition-metal atoms anchored on In2Se3 monolayer, whose catalytic performance can be controlled by ferroelectric switching based on adjusted d-band center and occupation of supported metal atoms. The polarization dependent activation allows effective control of the limiting potential of CO2 reduction on TM@In2Se3 (TM = Ni, Pd, Rh, Nb, and Re) as well as the reaction paths and final products on …

Microbial Activity Responses To Water Stress In Agricultural Soils From Simple And Complex Crop Rotations, Jorg Schnecker, D. Boone Meeden, Francisco Calderon, Michel Cavigelli, R. Michael Lehman, Lisa K. Tiemann, A. Stuart Grandy

Faculty Publications

Increasing climatic pressures such as drought and flooding challenge agricultural systems and their management globally. How agricultural soils respond to soil water extremes will influence biogeochemical cycles of carbon and nitrogen in these systems. We investigated the response of soils from long-term agricultural field sites under varying crop rotational complexity to either drought or flooding stress. Focusing on these contrasting stressors separately, we investigated soil heterotrophic respiration during single and repeated stress cycles in soils from four different sites along a precipitation gradient (Colorado, MAP 421 mm; South Dakota, MAP 580 mm; Michigan, MAP 893 mm; Maryland, MAP 1192 mm); …

Analysis Of Covid-19'S Influence On International Logistics Enterprises And Its Countermeasures A Case Study Of Dgf, Zhoutao Ruan

World Maritime University Dissertations

No abstract provided.

Allelopathic Influence Of Eragrostis Curvula Water Extract On Seed Germination And Seedling Growth Of Two Other Species, R. W. Coelho, R. E. Schmidt

IGC Proceedings (1977-2023)

Weeping lovegrass (Eragrostis curvula Schrad. Nees) is a very agressive tropical species and does not grow well with other species. This study was set up to investigate the allelopathic effect of various extract concentrations of weeping lovegrass on seed germination of white clover (Trifolium repens L.) and bentgrass (Agrostis stolonifera L.) and the seedling development of white clover. Labotatory and growth chamber studies were conducted. Extract concentrations of 13.6, 27.2, 40.8, 54.4, and 62.0 g/100mL of water were studied. Treatments were arranged in a completely ramdomized design with three replications. The allelopathic effect of weeping lovegrass was …

Effect Of Aging In Tillers Of Panicum Maximum On Leaf Elongation Rate, D. D. Carvalho, C. Matthew, J. Hodgson

IGC Proceedings (1977-2023)

Two cultivars of Guinea grass (P. maximum, Jacq.), Mombaça and Tanzânia, were cultivated in five litre pots, as single plants, in a green house. Plants were subjected to three defoliation levels (100, 200 and 400 mm height) for five successive monthly harvests. The experimental design was a 3x2 randomised block with five replicates. Three types of tiller (main, primary and secondary) were selected, at random, on each plant and leaf elongation rate (LER) above cutting height was measured, weekly, between harvests. There were significant differences (P < 0.05) in LER between tiller types in cv. Mombaça in all periods, but only in period two in cv. Tanzânia. In the last period tillers were classified, at random, as old (over four months age) mature (between two and four months) and young (between one and two months). Old tillers had a lower (P < 0.05) LER than the other two categories in both cultivars and lower (P < 0.05) SLA (specific leaf area) in Mombaça.