Correlative In Situ Nonlinear Optical Characteriztion Of Plasmonic Colloidal Nanoparticle Growth Dynamics, Stena C. Peterson

LSU Doctoral Dissertations

Colloidal noble metal nanoparticles are of extreme interest as nanomaterials and for the wide variety of their possible applications in nanomedicine. The unique linear and nonlinear optical processes associated with these nanomaterials can be studied using a variety of spectroscopic techniques including extinction, second harmonic generation (SHG), and two-photon fluorescence (TPF) spectroscopy. In order to better understand and optimize these nanomaterials for their desired applications, it is important to investigate the growth and photophysical dynamics associated with gold nanoparticles, silver-gold core-shell (Ag-Au CS) nanoparticles, and gold-silver-gold core-shell-shell (Au-Ag-Au CSS) nanoparticles in addition to how their size, surface morphology, composition. and …

Extreme Geomagnetic Storm Effects On Earth's Radiation Belts Observed By Calet On The International Space Station, Anthony W. Ficklin

LSU Doctoral Dissertations

This dissertation examines changes in Earth's energetic-particle environment using measurements from the Calorimetric Electron Telescope (CALET) on the International Space Station. Although CALET was designed primarily for high-energy cosmic-ray and gamma-ray observations, its count rates provide nearly continuous measurements of particles of ~1 MeV and above. The analysis uses the CHDX, CHDY, and IMC4X channels, which have approximate electron thresholds of $>\!1.5$, $\!>3.4$, and $\!>8.2$~MeV and proton thresholds of $>\!17$, $\!>37$, and $\!>52$~MeV, respectively. Because these measurements do not identify particle species, the observations are interpreted using their geographic and geomagnetic distributions, the relative …

The Study Of Hydrophobic Biomolecules With Matrix Assisted Laser Desorption Ionization Mass Spectrometry And Atomic Force Microscopy, Brandy L. Perkins

LSU Doctoral Dissertations

Abstract

Matrix assisted laser desorption ionization (MALDI) mass spectrometry (MS) can be used to obtain localization and chemical information of hydrophobic biomolecules on tissue samples.  A technique has been developed to modify a standard MALDI matrix that improves the selectivity for hydrophobic biomolecules on the tissue sample. The modification involves the use of a Group of Uniform Materials Based on Organic Salts (GUMBOS). GUMBOS are ionic liquids (IL) that are bulky organic ions with a counter ion that can be changed for tuning.  They are more stable than traditional matrices under vacuum.  Unlike traditional IL’s, the GUMBOS melting point ranges …

A Data-Driven Framework For Mitigating Breast Cancer Overdiagnosis: From Estimation To Risk-Adjusted Computer-Aided Diagnosis, William M. Brown Jr.

LSU Doctoral Dissertations

In Computer-Aided Diagnosis (CAD) of cancer, standard cost metrics (false-positives and false-negatives) fundamentally fail to account for overdiagnosis. Overdiagnosis is a critical scenario where a disease is correctly detected (true-positive) but is biologically indolent and would never have caused the patient harm or symptoms. While widely recognized in the medical community as a major healthcare crisis driving stressful and invasive overtreatment, overdiagnosis remains severely under-researched within computer science and engineering. This dissertation addresses this interdisciplinary gap by defining the three key computational challenges of overdiagnosis: (i) accurate estimation, (ii) harm quantification, and (iii) algorithmic mitigation. To overcome the estimation challenge, …

Scattered Light Noise At Ligo Livingston Observatory Induced By Microseismic Ground Motion, Debasmita Nandi

LSU Doctoral Dissertations

Gravitational waves are “ripples” in the fabric of spacetime and create a minuscule change in the distance between two points. After publishing his theory of general relativity in 1915, Albert Einstein predicted the existence of gravitational waves as a consequence of the theory. Almost 100 years after the theoretical prediction, gravitational waves were detected for the first time in 2015 by the Advanced LIGO detectors in Livingston, Louisiana, and Hanford, Washington. Gravitational waves have a very small amplitude, making it very challenging to detect them. Different types of noise sources either of instrumental or environmental origin can reduce the astrophysical …

Unraveling The Nanoscopic Characteristics Of The Heterogeneous Deep Eutectic Solvent Formed By Lauric Acid And N-Methylacetamide: An Experimental And Computational Approach, Laura X. Sepulveda

LSU Doctoral Dissertations

Deep eutectic solvents (DESs) are attractive systems for extraction and separation of compounds. One example of this is the DES formed by the combination of lauric acid (LA) and N-methylacetamide (NMA), system that has been shown to efficiently separate oil/water mixtures through gel formation between LA and oil molecules. Structural characterization of this system using small-angle X-ray scattering (SAXS) and vibrational spectroscopy revealed the existence of nanometer-scale LA domains embedded in a continuous polar NMA phase, where LA and NMA interact through hydrogen bonding. These LA domains are responsible for the separation efficiency of linear organic molecules. However, this DES …

Evaluating Soil Health And Crop Yield In Louisiana Agricultural Systems: Impacts Of Best Management Practices And Prediction Models, Hector J. Mendoza Lagos

LSU Doctoral Dissertations

The adoption of conservation management practices is critical for improving soil health, enhancing nutrient use efficiency, and sustaining crop productivity in row crop systems in Louisiana. This study evaluated the role of conservation agronomic practices, soil biochemical indicators, and machine learning predictive models to improve soil nutrient dynamics, soil health indicators, microbial communities (MC), and crop productivity on a corn (Zea mays L.) research plot scale and in a commercial forty-hectare cotton (Gassypium hirsutum L.)-corn-soybean (Glycine max L.) rotation system in northeast Louisiana. The objectives of the study were to evaluate soil nutrient dynamics and MCs under …

Momentum Space Algorithm For Electronic Structure Of Double-Incommensurate Trilayer Graphene, Kenneth Silver Beard

LSU Doctoral Dissertations

Numerical algorithms for computing the electronic structure of incommensurate 2D-materials using ab initio models are critical for predicting material properties and guiding experiments. For bilayers, momentum space and continuum models have been introduced to approximate observables of ab initio tight-binding models using a momentum description, despite the lack of periodicity in the tight-binding model required for Bloch theory. A similar structure has been introduced for double-incommensurate trilayers using a continuum model, where the three lattices are mutually incommensurate. However, this description leads to a four-dimensional lattice space, and numerical convergence of the density of states has been observed to be …

Machine Learning Based Models For Simulation And Analysis Of Bulk Earth Melt System, Abin Shakya

LSU Doctoral Dissertations

Understanding the segregation of bulk Earth melt systems into metallic (core) and silicate (mantle) phases under high-pressure and high-temperature conditions is central to modeling Earth’s interior, yet relevant experimental and computational studies remain limited. This work develops a machine learning–based simulation pipeline that iteratively couples first-principles (quantum mechanical) calculations with neural network training to generate high-fidelity force fields. Using major-element Fe–Mg–Si–O melt systems, with and without H and N, as testbeds, we demonstrate that this framework enables large-scale molecular dynamics simulations at near first-principles accuracy. We further introduce a sequence of phase identification methods, progressing from statistical binning of elemental …

Extremal Connectivity In Graphs And Matroids, Yiwei Ge

LSU Doctoral Dissertations

Connectivity is a central theme in both graph theory and matroid theory. This dissertation investigates extremal connectivity in graphs and matroids, with emphasis on unavoidable structures and minimal connectivity phenomena.

Chapter 2 introduces cycle-contraction minors of graphs and investigates their structural properties. We establish a connection between cc-minors and induced subgraphs via graph duality. The main result gives an unavoidable-families characterization for cc-minors of sufficiently large loopless $2$-connected graphs.

Chapter 3 studies super-minimally $3$-connected graphs, namely $3$-connected graphs that have no proper $3$-connected subgraphs. We establish extremal bounds on structural parameters of these graphs, including the minimum number of degree-$3$ …

Circuits And Enumeration Problems For Matroids, Christine H. Cho

LSU Doctoral Dissertations

This dissertation is a collection of work concerning the structure and enumeration of circuits and other distinguished sets in a matroid. The Tutte polynomial, recognized as the universal deletion-contraction invariant in matroid and graph theory, is a natural starting point when considering enumeration problems for matroids. The main result in Chapter 2 generalizes a theorem of Dean Lucas concerning the Tutte polynomial and its behavior under rank-preserving weak maps. This generalization provides an avenue for comparing the numbers of circuits, bases, rank-k flats, and hyperplanes of a matroid containing an element given two distinct, yet related, elements.

Chapter 3 addresses …

Forbidden Induced Restrictions And Unavoidable Minors In Matroids, Matthew P. Mizell

LSU Doctoral Dissertations

Targets are matroids that arise from a nested sequence of flats in a projective geometry. This class of matroids was introduced by Nelson and Nomoto, who found the forbidden induced restrictions for binary targets. In this dissertation, their result is generalized to targets arising from projective geometries over $GF(q)$. In addition, targets arising from nested sequences of affine flats are introduced and the forbidden induced restrictions for these affine targets are determined.

In 1963, Halin and Jung proved that every simple graph with minimum degree at least four has $K_5$ or $K_{2,2,2}$ as a minor. Mills and Turner proved an …

Biogeochemical Controls On Phosphorus Transport And Legacy Storage Across A Coastal Watershed, Lee Potter

LSU Doctoral Dissertations

Excess phosphorus (P) loading is a key driver of eutrophication and harmful algal blooms (HABs) in aquatic systems worldwide. This relationship is of increasing concern in coastal Louisiana, where climate variability, altered hydrology, and land-use change converge, resulting in increased hydrologic and nutrient loading into coastal systems. This dissertation examines controls on P cycling in the Lake Pontchartrain Basin through a multi-scale framework linking estuarine processes, watershed loading, climate and weather patterns, and sediment dynamics. The dissertation begins with an overview of the study region, P dynamics, and changes in hydrology and nutrient loading patterns. Chapter 2 presents a spatial …

Improving Stem Assessments: Strategies For Increasing The Accessibility And Adoption Of Two-Stage Exams, Kristina Callaghan

LSU Doctoral Dissertations

Over three decades of research have shown that students taught using active learning strategies achieve better learning outcomes compared to those taught using traditional methods. Two-stage exams, which pair a traditional exam with a group component, are an increasingly popular method for incorporating active learning within the assessment component of a course. Previous studies have shown this assessment strategy provides a variety of benefits for students, including increased engagement and collaboration, immediate feedback, and potentially increased content retention. However, the unique circumstances of each instructor can pose a non-trivial barrier to the implementation of two-stage exams. In this thesis, we …

Applications For The Quasi-Atomic Orbital And Constrained Density Functional Theory Methods On Catalytic Reactions, Alvaro David Loaiza Orduz

LSU Doctoral Dissertations

Selective activation of C–O, C–H, and C–C bonds underpins biomass upgrading, alkane functionalization, and CO₂ conversion. Despite their importance, the electronic factors governing catalytic performance remain incompletely understood, and many industrial processes still rely on empirical trends or material-specific observations. This dissertation addresses this gap by applying density functional theory (DFT), thermodynamic decomposition, and electronic-structure analysis to identify unifying principles of reactivity across transition-metal phosphides, vanadate oxides, copper-based electrocatalysts, and mixed IrO₂–RuO₂ layers. This work examines how charge transfer, orbital localization, and ligand-induced perturbations control reaction pathways in diverse catalytic systems. C–O bond scission in 2-methyltetrahydrofuran (MTHF) and methanol was …

Measurement Of 18f(Alpha,P)21ne With The Array For Nuclear Astrophysics And Structure With Exotic Nuclei (Anasen), Keilah S. Davis

LSU Doctoral Dissertations

Certain (α,p) reactions on proton-rich nuclei are among the most important nuclear reactions occurring during Type I X-ray bursts, as well as being impactful in stellar explosions during the Asymptotic Giant Branch (AGB) phase and on accreting white dwarfs (WD). However, large uncertainties remain for reaction rates on some radioactive nuclei due to the lack of direct measurements. The Array for Nuclear Astrophysics and Structure with Exotic Nuclei (ANASEN) is a gas target and charged-particle detector designed for direct measurements of (α,p) reactions. ANASEN was redesigned with two hexagonal barrels of 100-µm-thick silicon strip surrounding the beam axis over a …

Metacommunity Coupled Epidemiological And Biophysical Modeling Of An Emergent Coral Disease, Benjamin Holmes Farmer

LSU Doctoral Dissertations

Emerging infectious diseases pose imminent risk to the marine realm and coral reefs in particular. Since its emergence in 2014, stony coral tissue loss disease (SCTLD) has dramatically reduced living coral cover in Florida and charted a similar course in the Caribbean. SCTLD is by far the most severe coral disease in history and has driven highly susceptible species to local extinction, yet the mechanisms driving the regional epizootic are not well understood. Here, we developed reef-scale parameterizations of disease spread using model sites in the lower Florida Keys, developed extensive metacommunity habitat maps for the US Caribbean, and then …

Quantifying Uncertainty In Landscape Evolution And Provenance Analysis: Insights From Statistical And Numerical Modelling, Vivian Carmello Grom

LSU Doctoral Dissertations

Landscape evolution models (LEMs) and detrital zircon provenance are widely used to investigate Earth surface processes, yet both face challenges related to quantifying model behavior and interpreting sedimentary signals under realistic, heterogeneous conditions. This thesis addresses these challenges through analysis and case studies that develop and apply new approaches for analyzing landscape dynamics and assessing uncertainties in sediment provenance.

Chapter 1 introduces a quantitative framework for evaluating LEM outputs using Shannon Entropy, Moran’s I, and Geary’s C. Applied to simulations with steady uplift, periodic uplift, spatially variable uplift, and a timeseries of DEMs, these metrics capture spatial organization and information …

Satellite-Mediated Quantum Clock Synchronization: Towards Precise Timing At A Global Scale, Sage B. Ducoing

LSU Doctoral Dissertations

Accurate timekeeping is essential for scientific and technological advancements, particularly in areas of communication, networking, navigation, and high precision measurements. While many methods of time resolution are already established using classical resources, they fail to combine high precision outcomes with large-scale implementations. Additionally, numerous quantum networking architectures using satellite-assisted methods have demonstrated quantum communication on scales exceeding ground-based methods. For these reasons, we propose the use of a time synchronization method by which pairs of highly time-correlated photons are exchanged between clocks on satellites and clocks on Earth, al- lowing users to reconstruct the time offsets between their clocks. This …

Properties Of Liquid Fe-Ni Alloys Under Planetary Core Conditions And Their Geophysical Implications, Sajin Satyal

LSU Doctoral Dissertations

The composition of Earth’s core remains unsolved, yet it carries critical implications for planetary evolution, thermal history, magnetic fields, and habitability. Planetary models derived from seismological observations, such as the Preliminary Reference Earth Model (PREM), indicate that Earth’s core is significantly less dense than pure iron, implying the presence of light elements, including sulfur, carbon, hydrogen, oxygen, and silicon. However, the exact composition and distribution of these elements remain largely unknown. In constraining Earth’s core composition, the density and compressional wave velocity of iron-rich alloys are often compared with seismologically derived models. However, no single iron–light-element alloy can simultaneously reproduce …

Determining The 17f(Α,P)20ne Reaction Rate For Application In Type I X-Ray Bursts, William Braverman

LSU Doctoral Dissertations

The ¹⁷F(α, p)²⁰Ne reaction has been identified as an alternate pathway for breakout from the hot-CNO cycle that can be important in some X-ray burst scenarios. The ¹⁷F(α, p)²⁰Ne reaction rate was previously determined through a parameterized exponential S-factor with a large enhancement from thermally-excited states based on statistical models with large uncertainties. We have measured the time-inverse ²⁰Ne(p,α)¹⁷F cross section at center-of-mass energies ranging from 5.50 to 7.10 MeV using an activation method with a proton beam on a neon gas cell. Coincident detections of 511-keV γ-rays, resulting from electron-positron …

Practical Real-Time Permanent Magnet Energy Spectrometer Using A Diode Array For Therapeutic Electron Beam Tuning And Quality Assurance, Mason W. Heath

LSU Doctoral Dissertations

Purpose: Develop a practical, real-time permanent magnet electron energy spectrometer and evaluate it for beam tuning and quality assurance (QA) of therapeutic electron beams.

Methods: Aim 1: A 0.55 T permanent magnet was coupled to Sun Nuclear SRS MapCHECK® PC boards, providing two interlaced diode arrays. Detector response, R_meas(z_diode) versus diode position z_diode, was extracted from raw diode array readings, correcting for diode sensitivity and other factors. Using Monte Carlo (MC) computed, monoenergetic detector response functions, a curve-fitting algorithm extracted the energy spectrum, from R_meas(z_diode). The energy spectra for 7-20 …

Dynamics Of Meandering River Cutoffs And Post-Cutoff Sedimentation, Dylan T. Shoemaker

LSU Doctoral Dissertations

Meander cutoffs are pivotal events in the life cycle of rivers, abruptly adjusting flow fields and reshaping riparian environments. The consequences of cutoffs extend beyond geomorphology, influencing aquatic ecosystems, sediment storage within the floodplain, nutrient and contaminant cycling, and risks to human infrastructure. Yet, research of cutoffs has not produced a clear conceptual understanding of the persistence of oxbow lakes, and the dynamics of post-cutoff planform change that aligns with the observations of cutoff events on a global scale. This research aims to use satellite imagery to further clarify our understanding of the post-cutoff morphometrics and processes that constrain the …

Synthesis And Evaluation Of Bodipy-, Azabodipy- And Chlorin-Based Conjugates For Imaging And Photodynamic Therapy Of Egfr-Overexpressing Cancers, Simran Dhingra

LSU Doctoral Dissertations

This dissertation discusses the design of EGFR-targeted small-molecule agents that unite molecular imaging with photodynamic therapy. Chapter 1 frames the clinical need for early detection and selective treatment and surveys BODIPY, aza-BODIPY, and chlorin scaffolds as tunable chromophores for near-infrared imaging and photosensitization. It also outlines EGFR as a validated target and compares two ligand classes used throughout this work: the tyrosine kinase inhibitor erlotinib and the cyclic peptide KLARLLT.

Chapter 2 describes the synthesis of a near-IR BODIPY bearing either one or two erlotinib units. Docking and SPR show specific interactions with the EGFR kinase domain, and both conjugates …

Computational Nanoscale Investigations Of Structure, Dynamics, And Reactivity At Solid–Liquid Interfaces, Golam Azom

LSU Doctoral Dissertations

Interfaces where two or more condensed phases meet govern phenomena central to catalysis, electrochemical energy conversion, separations, and environmental remediation. Their structural heterogeneity and dynamic nature make them challenging to probe experimentally, but computer simulations provide molecular-level insights into processes that remain inaccessible to experiments. This dissertation employs ab initio molecular dynamics (AIMD), classical molecular dynamics, and machine-learned interatomic potentials to investigate the structure, dynamics, and proton transport at graphene oxide (GO)–liquid interfaces.

The first project explores aqueous GO interfaces across a spectrum of oxidation states that extends from highly oxidized sheets to fully reduced graphene. Deep neural network force …

Modeling Nutrient Functions: Strengthening The Reliability And Applicability Of Ecosystem Service Models For Land Use Decision-Making, Mariam Gabriela Valladares Castellanos

LSU Doctoral Dissertations

Effective water quality management requires a clear understanding of both the magnitude and spatial distribution of nutrient retention and export across dynamic landscapes, given their direct implications for drinking water supply, ecosystem integrity, fisheries, and recreational uses. Equally important is anticipating trade-offs from management actions, which can alter ecosystem functioning and the flow of services. Modeling tools provide a means to predict nutrient outcomes, evaluate these trade-offs, and support decision-making; however, their utility is often constrained by persistent challenges, including model uncertainty, limited applicability in data-scarce regions, and insufficient empirical foundations to inform scenario-driven decision-making. This dissertation addresses these gaps …

How The Inter-Nucleon Force Shapes Emergent Collectivity And Imparts Uncertainties In Ab Initio Nuclear Observables, Kevin Becker

LSU Doctoral Dissertations

The importance of collective motion in atomic nuclei has been well-established for many decades. Even before the advent of the nuclear shell model and its much-needed answers to surprising empirical phenomena, collectivity and surface deformation have played a vital role in broadening our knowledge. Reconciling the collective and single-particle camps into a unified description required tremendous strides in the application of group theory and advances in high-performance supercomputing, and thanks to these efforts the symmetry-adapted no-core shell model, or SA-NCSM, has developed into a reliable model for the study of deformed light and medium-mass nuclei. State-of-the-art calculations reveal remarkably simple …

Compound-Specific Isotope Records Of Dust Provenance And Hydroclimate In The North Pacific And Marginal Seas Of East Asia: Integrating N-Alkane Δ13c And Δd With Standardized Analytical Frameworks, Julian W. Traphagan

LSU Doctoral Dissertations

This dissertation presents advancements in compound-specific isotope analysis (CSIA) through methodological innovation and paleoclimate reconstruction in Central and East Asia. Utilizing plant wax n-alkanes from International Ocean Discovery Program (IODP) and Ocean Drilling Program (ODP) sediment cores, this research reconstructs atmospheric circulation shifts responding to tectonic evolution and climate transitions since the Late Miocene.

Chapter 1 investigates hydrogen isotope compositions (δD_wax) from IODP U1430 (Sea of Japan), ODP 886, and ODP 1208 (North Pacific) to trace dust provenance and hydroclimate changes since ~13 Ma. Results reveal persistently segmented source-to-sink systems: the Sea of Japan dominated by westerly …

Investigation Of Co-Current And Counter-Current Multiphase Flow In Upstream Drilling And Production Applications, Hazem Fleifel

LSU Doctoral Dissertations

In the domain of upstream Petroleum Engineering, the dynamics of co-current and counter-current multiphase flows present huge challenges, significantly impacting the efficiency of associated processes. This study investigates two specific applications concerning these flow behaviors, involving both laboratory experiments and transient computer simulations. This work investigates two distinct well control and production enhancement processes, involving multiphase flow dynamics: the bullheading kill procedure and liquid-assisted gas lift (LAGL).

The first topic (Topic 1) explores the bullheading process, a type of well control methods, by challenging the traditional understanding that gas removal efficiency increases monotonically with injection pump flow rate. Through 1D …

Patterns And Processes Behind Secretive Marshbird Movement, Abundance, And Distribution Across Southeastern Louisiana, Leah Moran

LSU Doctoral Dissertations

Restoration and conservation of coastal Louisiana hinges on understanding the patterns and processes underlying habitat heterogeneity on the landscape and therefore the species that inhabits this region, including secretive marshbirds. Elusive in nature, this guild of birds has evolved under dynamic hydroperiods, and myriad plant communities present within wetlands. Only recently, however, has research focused on the role of hydrologic dynamics and vegetative structure and distribution on abundance, movement and detection of marshbirds, specifically within southeastern Louisiana. This study aimed to quantify the ecological patterns and processes, particularly hydrologic processes and landscape structure, driving breeding secretive marshbird movement, abundance and …