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Design And Synthesis Of N-Succinyl-L,L-2.6-Diaminopimelic Acid Desuccinylase Inhibitors As Potential Novel Antibiotics, Thomas Dipuma 2023 Loyola University Chicago

Design And Synthesis Of N-Succinyl-L,L-2.6-Diaminopimelic Acid Desuccinylase Inhibitors As Potential Novel Antibiotics, Thomas Dipuma

Master's Theses

N-Succinyl-L,L-2,6-Diaminopimelic Acid Desuccinylase (DapE) is a bacterial enzyme located in the lysine biosynthetic pathway of all Gram-negative and most Gram-positive species of bacteria including the notorious ESKAPE pathogens, or pathogenic strains of bacteria that have developed significant levels of resistance to currently available antibiotics. As a means to combat this challenge of growing antimicrobial resistance, we have identified the bacterial enzyme DapE as a conserved, novel enzymate target within these resistant bacterial strains,as DapE is responsible for the production of m-DAP and lysine which are ultimately employed in bacterial cell wall synthesis. The overall aim of this research is to …


Meet Me In The Middle: A Scoping Review On Understanding Adolescent Needs In Climate Communication, Gwendolyn Monica Hoff Anderson 2023 University of San Francisco

Meet Me In The Middle: A Scoping Review On Understanding Adolescent Needs In Climate Communication, Gwendolyn Monica Hoff Anderson

Master's Projects and Capstones

The greatest effects of climate change are likely to be felt by youth. Young people are disproportionately affected by climate change due to their critical developmental stage and lack of power, and they experience both higher severity and prevalence of mental health issues related to climate change. Strong emotions have long been recognized as potential catalysts for action, or they may lead to paralyzing feelings of being overwhelmed. Climate communication is a critical tool to spark climate concern and encourage action. Activism, in turn, may help youth manage their anxiety about climate change. This scoping review examines emerging evidence on …


The Loneliest Galaxies In The Universe: A Gama And Galaxy Zoo Study On Void Galaxy Morphology., Lori E. Porter 2023 University of Louisville

The Loneliest Galaxies In The Universe: A Gama And Galaxy Zoo Study On Void Galaxy Morphology., Lori E. Porter

College of Arts & Sciences Senior Honors Theses

The large-scale structure (LSS) of the Universe is comprised of galaxy filaments, tendrils, and voids. The majority of the Universe’s volume is taken up by these voids, which exist as underdense, but not empty, regions. The galaxies found inside voids are void galaxies and expected to be some of the most isolated objects in the Universe. However, their standard morphology remains poorly studied. This study, using the Galaxy and Mass Assembly (GAMA) data and Galaxy Zoo survey, aims to remedy this. For completeness purposes, we use void galaxies identified by Alpaslan et al. (2014) with stellar masses (M*) of 10 …


Soil Health And Remediation For Urban Gardens In Utah, Melissa Chilinski 2023 Utah State University

Soil Health And Remediation For Urban Gardens In Utah, Melissa Chilinski

All Graduate Plan B and other Reports

Urban environments are at an increased risk of soil contamination and poor soil health due to anthropogenic causes. As healthy farmland is developed, new urban farmers and gardeners are often left growing food on unwanted land with unknown histories of previous use. Varied research and methods for obtaining healthy soils can cause new growers to make decisions that negatively impact soil health and fertility, or on the other hand, conflicting information can cause individuals to become unnecessarily fearful of common soil contaminants and their effect on human health. Common soil contaminants, like trace metals (often referred to as heavy metals) …


The Novel Chlorination Of Zirconium Metal And Its Application To A Recycling Protocol For Zircaloy Cladding From Spent Nuclear Fuel Rods, Breanna K. Vestal 2023 University of Tennessee, Knoxville

The Novel Chlorination Of Zirconium Metal And Its Application To A Recycling Protocol For Zircaloy Cladding From Spent Nuclear Fuel Rods, Breanna K. Vestal

Doctoral Dissertations

A novel protocol has been developed for the chemical removal of zirconium alloy (Zircaloy) cladding from spent nuclear fuel rods and subsequent isolation and purification of nuclear-grade zirconium chloride derived therefrom. This protocol is based on the chemistry developed from two new scientific findings.

First, two new oxidative chlorination reactions have been discovered for zirconium metal. In both solvents, zirconium can be quantitatively chlorinated at temperatures less than 150°C, with the operative equations seen below. In sulfur monochloride, the reaction is completed in 2 – 4 hours via surface etching, exhibiting 0th order kinetic behavior. The elemental sulfur byproduct …


Subterraneans: A Regional Earth Dwelling For Comfort And Beauty, Isaak Benchoff 2023 University of Arkansas, Fayetteville

Subterraneans: A Regional Earth Dwelling For Comfort And Beauty, Isaak Benchoff

Architecture Undergraduate Honors Theses

Subterraneans is a study of an affordable, self-sufficient, sustainable, and dignified housing prototype for the region of Northwest Arkansas. It is a design process investigation based on the ideas of turning a local, sustainable material into affordable homes that can be built within a community of people sharing land and resources. The homes would utilize as many natural materials as possible to minimize the impact on the Earth and the cost to the owners.

Research looked at many different vernacular building precedents as well as the work done by contemporary design firms in the area of economical, low-impact, and passively …


Leveraging Aruco Fiducial Marker System For Bridge Displacement Estimation Using Unmanned Aerial Vehicles, Mohamed Aly 2023 University of Nebraska-Lincoln

Leveraging Aruco Fiducial Marker System For Bridge Displacement Estimation Using Unmanned Aerial Vehicles, Mohamed Aly

Computer Science and Engineering: Theses, Dissertations, and Student Research

The use of unmanned aerial vehicles (UAVs) in construction sites has been widely growing for surveying and inspection purposes. Their mobility and agility have enabled engineers to use UAVs in Structural Health Monitoring (SHM) applications to overcome the limitations of traditional approaches that require labor-intensive installation, extended time, and long-term maintenance. One of the critical applications of SHM is measuring bridge deflections during the bridge operation period. Due to the complex remote sites of bridges, remote sensing techniques, such as camera-equipped drones, can facilitate measuring bridge deflections. This work takes a step to build a pipeline using the state-of-the-art computer …


Deephtlv: A Deep Learning Framework For Detecting Human T-Lymphotrophic Virus 1 Integration Sites, Johnathan Jia, Johnathan Jia 2023 The Texas Medical Center Library

Deephtlv: A Deep Learning Framework For Detecting Human T-Lymphotrophic Virus 1 Integration Sites, Johnathan Jia, Johnathan Jia

The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences Dissertations and Theses (Open Access)

In the 1980s, researchers found the first human oncogenic retrovirus called human T-lymphotrophic virus type 1 (HTLV-1). Since then, HTLV-1 has been identified as the causative agent behind several diseases such as adult T-cell leukemia/lymphoma (ATL) and a HTLV-1 associated myelopathy or tropical spastic paraparesis (HAM/TSP). As part of its normal replication cycle, the genome is converted into DNA and integrated into the genome. With several hundreds to thousands of unique viral integration sites (VISs) distributed with indeterminate preference throughout the genome, detection of HTLV-1 VISs is a challenging task. Experimental studies typically use molecular biology …


An Analysis Of Energy Production And Efficiency In Various Longbow Archery Models, Hannah McPherson 2023 Bridgewater College

An Analysis Of Energy Production And Efficiency In Various Longbow Archery Models, Hannah Mcpherson

Honors Projects

An analysis of the energy production and efficiency of three lab-tested longbow models is undertaken. The first model, which is constructed to not allow flexing of limbs and which uses a frictionless cart and track in place of an arrow, demonstrated an efficiency of 50% +/- 40%. The second model, which is constructed similarly to the first with the exception of a wooden dowel now being used as an arrow-like object, demonstrated an efficiency of 13% +/- 3%. The last model, a 3D printed longbow with flexible limbs using the wooden dowel as an arrow-like object, demonstrated an efficiency of …


Logic And Rationality, Rohit J. Parikh 2023 CUNY Graduate Center

Logic And Rationality, Rohit J. Parikh

Publications and Research

Logic aims at truth, or more accurately, at deriving some truths from other truths. But why are we interested in truth in the first place? Surely one reason is that relying on truth makes it easier to make better choices.

One could think of Game theory as a tool which bridges the gap between logic and rationality.

Decision theory - or single agent game theory tells us when to make the best choice in a game of us against nature. But nature has no desire to further or frustrate our efforts. Nature is mysterious but not malign. Things change when …


Using Object Detection To Navigate A Game Playfield, Peter Kearnan Hyde-Smith 2023 Marquette University

Using Object Detection To Navigate A Game Playfield, Peter Kearnan Hyde-Smith

Master's Theses (2009 -)

Perhaps the crown jewel of AI is the self-navigating agent. To take many sources of data as input and use it to traverse complex and varied areas while mitigating risk and damage to the vehicle that is being controlled, visual object detection is a key part of the overall suite of this technology. While much efforts are being put towards real-world applications, for example self-driving cars, healthcare related issues and automated manufacturing, we apply object detection in a different way; the automation of movement across a video game play field. We take the TensorFlow Object Detection API and use it …


Wenonah And Public Memory: The Struggle For Place In The Lover’S Leap And Beyond, Adam Gaffey, Monica De Grazia, Iyekiyapiwiƞ Darlene St. Clair, Jill Yohe 2023 Winona State University

Wenonah And Public Memory: The Struggle For Place In The Lover’S Leap And Beyond, Adam Gaffey, Monica De Grazia, Iyekiyapiwiƞ Darlene St. Clair, Jill Yohe

CLASP Lecture Series

This panel will explore how the lover’s leap narrative and its representation of Native American figures has been used to forge distinctive visions of public memory both in and beyond Winona, Minnesota. For most, details of the lover’s leap are reduced to Wenonah’s fatal action, specifically how she protested her family’s rigid customs of arranged marriage by jumping to her death from a bluff atop the Mississippi River. The goal of this panel is to offer a fuller account of the purposes this story has served in popular memory and the implications of its persistence for different audiences, past and …


Error Analysis Of A Fully Discrete Projection Method For Magnetohydrodynamic System, Qianqian Ding, Xiaoming He, Xiaonian Long, Shipeng Mao 2023 Missouri University of Science and Technology

Error Analysis Of A Fully Discrete Projection Method For Magnetohydrodynamic System, Qianqian Ding, Xiaoming He, Xiaonian Long, Shipeng Mao

Mathematics and Statistics Faculty Research & Creative Works

In this paper, we develop and analyze a finite element projection method for magnetohydrodynamics equations in Lipschitz domain. A fully discrete scheme based on Euler semi-implicit method is proposed, in which continuous elements are used to approximate the Navier–Stokes equations and H(curl) conforming Nédélec edge elements are used to approximate the magnetic equation. One key point of the projection method is to be compatible with two different spaces for calculating velocity, which leads one to obtain the pressure by solving a Poisson equation. The results show that the proposed projection scheme meets a discrete energy stability. In addition, with the …


The Vehicle Routing Problem With Simultaneous Pickup And Delivery And Occasional Drivers, Vincent F. YU, Grace ALOINA, Panca JODIAWAN, Aldy GUNAWAN, Tsung-C. HUANG 2023 Singapore Management University

The Vehicle Routing Problem With Simultaneous Pickup And Delivery And Occasional Drivers, Vincent F. Yu, Grace Aloina, Panca Jodiawan, Aldy Gunawan, Tsung-C. Huang

Research Collection School Of Computing and Information Systems

This research addresses the Vehicle Routing Problem with Simultaneous Pickup and Delivery and Occasional Drivers (VRPSPDOD), which is inspired from the importance of addressing product returns and the emerging notion of involving available crowds to perform pickup and delivery activities in exchange for some compensation. At the depot, a set of regular vehicles is available to deliver and/or pick up customers’ goods. A set of occasional drivers, each defined by their origin, destination, and flexibility, is also able to help serve the customers. The objective of VRPSPDOD is to minimize the total traveling cost of operating regular vehicles and total …


A New Global Divergence Free And Pressure-Robust Hdg Method For Tangential Boundary Control Of Stokes Equations, Gang Chen, Wei Gong, Mariano Mateos, John R. Singler, Yangwen Zhang 2023 Missouri University of Science and Technology

A New Global Divergence Free And Pressure-Robust Hdg Method For Tangential Boundary Control Of Stokes Equations, Gang Chen, Wei Gong, Mariano Mateos, John R. Singler, Yangwen Zhang

Mathematics and Statistics Faculty Research & Creative Works

In Gong et al. (2020), we proposed an HDG method to approximate the solution of a tangential boundary control problem for the Stokes equations and obtained an optimal convergence rate for the optimal control that reflects its global regularity. However, the error estimates depend on the pressure, and the velocity is not divergence free. The importance of pressure-robust numerical methods for fluids was addressed by John et al. (2017). In this work, we devise a new HDG method to approximate the solution of the Stokes tangential boundary control problem; the HDG method is also of independent interest for solving the …


Named Entity Recognition From Biomedical Text, Maged Guirguis 2023 American University in Cairo

Named Entity Recognition From Biomedical Text, Maged Guirguis

Theses and Dissertations

As vast amounts of unstructured data are becoming available digitally, computer-based methods to extract relevant and meaningful information are needed. Named entity recognition (NER) is the task of identifying text spans that mention named entities, and to classify them into predefined categories. Despite the existence of numerous and well-versed NER methods, the bio-medical domain remains under-studied. The objective of this research is to identify an efficient technique for NER tasks from biomedical data. This is achieved by investigating using deep learning technologies namely pre-trained BERT [1] model and its variances SciBERT [2] and BioBERT [3]. Preprocessing the data before passing …


Evidence Of Sea Level Rise At The Peruvian Coast (1942-2019), Bismarck Jigena-Antelo, Carol Estrada-Ludeña, Stephan Howden, Wilmer Rey, Jorge Paz-Acosta, Patricia Lopez-García, Eric Salazar-Rodriguez, Nieves Endrina, Juan J. Muñoz-Pérez 2023 University of Cadiz

Evidence Of Sea Level Rise At The Peruvian Coast (1942-2019), Bismarck Jigena-Antelo, Carol Estrada-Ludeña, Stephan Howden, Wilmer Rey, Jorge Paz-Acosta, Patricia Lopez-García, Eric Salazar-Rodriguez, Nieves Endrina, Juan J. Muñoz-Pérez

Faculty Publications

The present work aims to analyze the variability of the sea level of the Peruvian coast with time series over a long observation period (Seventy-eight years, from 1942 to 2019). Data came from the Talara, Callao and Matarani tide gauge stations located at the north, center and south of the coast. Variations of sea level as well as air and seawater surface temperature were analyzed. Among the different scenarios studied, a sea level rise of 6.79, 4.21 and 5.16 mm/year for Talara, Callao and Matarani, respectively was found during the 1979–1997 nodal cycle. However, these results decreased significantly during the …


Session11: Skip-Gcn : A Framework For Hierarchical Graph Representation Learning, Jackson Cates, Justin Lewis, Randy Hoover, Kyle Caudle 2023 SDSMT

Session11: Skip-Gcn : A Framework For Hierarchical Graph Representation Learning, Jackson Cates, Justin Lewis, Randy Hoover, Kyle Caudle

SDSU Data Science Symposium

Recently there has been high demand for the representation learning of graphs. Graphs are a complex data structure that contains both topology and features. There are first several domains for graphs, such as infectious disease contact tracing and social media network communications interactions. The literature describes several methods developed that work to represent nodes in an embedding space, allowing for classical techniques to perform node classification and prediction. One such method is the graph convolutional neural network that aggregates the node neighbor’s features to create the embedding. Another method, Walklets, takes advantage of the topological information stored in a graph …


2d Respiratory Sound Analysis To Detect Lung Abnormalities, Rafia Sharmin Alice, KC Santosh 2023 University of South Dakota

2d Respiratory Sound Analysis To Detect Lung Abnormalities, Rafia Sharmin Alice, Kc Santosh

SDSU Data Science Symposium

Abstract. In this paper, we analyze deep visual features from 2D data representation(s) of the respiratory sound to detect evidence of lung abnormalities. The primary motivation behind this is that visual cues are more important in decision-making than raw data (lung sound). Early detection and prompt treatments are essential for any future possible respiratory disorders, and respiratory sound is proven to be one of the biomarkers. In contrast to state-of-the-art approaches, we aim at understanding/analyzing visual features using our Convolutional Neural Networks (CNN) tailored Deep Learning Models, where we consider all possible 2D data such as Spectrogram, Mel-frequency Cepstral Coefficients …


Two-Stage Approach For Forensic Handwriting Analysis, Ashlan J. Simpson, Danica M. Ommen 2023 Iowa State University

Two-Stage Approach For Forensic Handwriting Analysis, Ashlan J. Simpson, Danica M. Ommen

SDSU Data Science Symposium

Trained experts currently perform the handwriting analysis required in the criminal justice field, but this can create biases, delays, and expenses, leaving room for improvement. Prior research has sought to address this by analyzing handwriting through feature-based and score-based likelihood ratios for assessing evidence within a probabilistic framework. However, error rates are not well defined within this framework, making it difficult to evaluate the method and can lead to making a greater-than-expected number of errors when applying the approach. This research explores a method for assessing handwriting within the Two-Stage framework, which allows for quantifying error rates as recommended by …


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