Physical Sciences and Mathematics Commons^™

Design And In Silico Modeling Of Heterocyclic-Based Xanthone Derivatives As Potential Anticancer Agents Through Tyrosine Kinase Inhibition, Yehezkiel Steven Kurniawan, Ervan Yudha, Nela Fatmasari, Radite Yogaswara, Harno Dwi Pranowo, Eti Nurwening Sholikhah, Jumina Jumina

Makara Journal of Science

Cancer is one of the deadliest diseases nowadays, and tyrosine kinase receptors play crucial roles in cancer cell survival, differentiation, proliferation, and migration. This study designed and developed a new inhibitor from heterocyclic-based xanthone derivatives to target two tyrosine kinase receptors, epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR), through in silico screening. Eighteen heterocyclic-based xanthones were evaluated through molecular docking for both receptors. All heterocyclic-based xanthones gave the root mean square deviation (RMSD) value lower than 2.00 Å. Xanthone with isobenzothiazole substituent (iBzThio) was found as the most potent inhibitor with binding energies of -10.60 and …

Anthrone-Based Dummy Molecularly Imprinted Polymer For The Selective Detection Of Fluorene And Phenanthrene In Simulated River Water, Aria Pinandita, Nurrahmi Handayani, Muhammad Iqbal, Untung Triadhi, Rusnadi Rusnadi, Samitha Dewi Djajanti, Muhammad Bachri Amran, Muhammad Ali Zulfikar

Makara Journal of Science

A dummy-template molecularly imprinted polymer (DMIP) was synthesized via precipitation polymerization using anthrone as a template analog for the selective analysis of low-molecular-weight polycyclic aromatic hydrocarbons (PAHs), specifically fluorene and phenanthrene. Styrene, benzoyl peroxide, and ethylene glycol dimethacrylate were employed as the functional monomer, radical initiator, and crosslinking agent, respectively. The synthesized polymers were characterized by Fourier-transform infrared spectroscopy, scanning electron microscopy, and particle size analysis. The imprinting factors were 1.16 and 1.09 for fluorene and phenanthrene, respectively, indicating enhanced affinity of the imprinted sites. High-performance liquid chromatography analysis following DMIP-based solid-phase extraction yielded recoveries of 91.49% ± 3.87% for …

Strong Gravitational Lensing Of Balart-Vagenas Regular Black Holes, Akif Pervez, Hassan Moin Ud Din, Handika Satrio Ramdhan

Makara Journal of Science

Gravitational lensing is an integral part of Einstein general theory of relativity. The existence of singularity in standard black holes is a hurdle for understanding the properties of black holes. The introduction of nonlinear electrodynamics (NLED) offers an intriguing possibility of constructing non-singular black hole. Gravitational lensing by the photon sphere probes the physical properties of lens objects such as black holes. This work presents a strong deflection limit analysis in a general asymptotically flat, stationary, spherically symmetric spacetime. We extend the analysis of the light deflection around the photon sphere-complete capture, and set a strong field limit that is …

A Ferrocene-Modified Carbon Electrode Prepared From Coconut Shell Char For Cu(Ii) Detection In Water, Nabila Putri Aulia, Fitria Rahmawati, Abu Masykur, Eddy Heraldy

Makara Journal of Science

A ferrocene (Fc)-modified carbon electrode was prepared from coconut shell char (CSC), which was activated with NaOH to produce an activated coconut shell carbon (Ac-CSC). The carbon electrode was designed as a printed-carbon electrode consisting of working, counter and reference electrodes in a single piece, called a screen-printed carbon electrode, or SPCE. An Fc solution was applied to the working electrode part at 10%, 20% and 30% mass of the SPCE, producing an SPCE-Fc as an electrochemical sensor for Copper ions Cu(II) detection. The prepared activated carbon was analysed by XRD, FTIR, SEM/EDX, surface area analysis and impedance measurement to …

Ai Adoption In Research Administration At Emerging Research Institutions, Dylan Ruediger, Ruby Macdougall, Stefanie Brachfield, Douglas R. Dechow, Jonathan Parker, Jana Remy

Library Articles and Research

"With funding from the National Science Foundation’s GRANTED program (grant #2437518), Ithaka S+R, Chapman University, and Montclair State University organized two workshops to help research administrators consider how to leverage AI to build research capacity at ERIs. Our first workshop, held at Montclair State in September 2025, brought together 31 participants from 13 academic and medical institutions in the New York/New Jersey/Pennsylvania region. Our second workshop, hosted by Chapman University on December 5, 2025, included 32 participants from 13 colleges and universities in Southern California. The approximately 2,600 ERIs in the United States receive a disproportionately small amount of federal …

Patterns Of Multimorbidity Among Low-Income Adults Who Smoke With Implications For Tailored Interventions: A Cluster Analysis Using A Mixture Of Bernoulli Model, Monique T. Cano, Michael R. Lindstrom, Oscar F. Rojas Perez, Ricardo F. Muñoz

School of Mathematical & Statistical Sciences Faculty Publications

Introduction: Smoking cigarettes remains a leading modifiable risk factor for preventable health conditions. In the United States, the health burden of smoking disproportionately impacts low-income individuals. Multimorbidity is common in this group, complicating treatment and worsening outcomes. Identifying multimorbidity clusters can support targeted, individualized interventions. This study aimed to identify multimorbidity clusters among individuals who smoke and experience economic hardship and provide clinical recommendations to enhance health outcomes.

Method: Individuals who smoke and experience economic hardship (N = 60) were recruited from the San Francisco Health Network (SFHN) and were assessed for physical and mental conditions. Cluster analysis was …

The Core-Modulation Architecture (Cma): A Structural Overview Of A 14-Paper Research Program (Preprint), Griselda Poe

Publications and Research

This document provides a structural overview of the Core-Modulation Architecture (CMA), a 14-paper research program on cognition, communication, and AI interaction.

The series specifies the conditions under which cognition operates, terminates, fails, and generates structure. Rather than describing cognition by its contents (beliefs, emotions, decisions), it defines cognition through its underlying architecture: constraint-governed processing across layers with distinct termination conditions.

The framework introduces a layered model consisting of Core processing (constraint preservation and structural coherence) and Modulation (affective calibration and social interface adjustment), extended by a Prior layer as the source of constraints. Across the series, phenomena such as miscommunication, …

The Effects Of Affordability And Quality Of Care On Utilization Of Primary Healthcare Among Rural Residents In Twifo Ati-Morkwaa District, Ghana: A Qualitative Study, Peter Ansah Boakye, Francis Tei-Nartey, Gideon Owusu

Michigan Tech Publications

Objective: This qualitative study examines how affordability and quality of care influence the utilization of primary healthcare (PHC) services among rural residents in the Twifo Ati-Morkwaa District, Ghana. While Ghana has implemented policies such as CHPS and NHIS to improve access, subjective experiences of rural residents regarding total costs of care and perceived quality remain underexplored. Methods: We conducted a qualitative cross-sectional study between April and September 2024 using purposive and snowball sampling. Ten gender-segregated focus group discussions (FGDs; n = 90 residents) and six in-depth interviews (IDIs) with PHC providers were conducted. Data were collected in Twi, transcribed and …

Association Between The Dietary Index For Gut Microbiota (Di-Gm) And Colorectal Cancer In The Plco Cohort, Bezawit E. Kase, Angela D. Liese Ph.D., Jiajia Zhang Ph.D., Elizabeth Angela Murphy, Susan E. Steck Phd, Mph, Rd

Faculty Publications

Objectives: The study aimed to examine the association between a dietary index for gut microbiota (DI-GM) and the risk of incident colorectal cancer (CRC). Clarifying the role of diet-induced alterations in the composition and function of gut microbiota on the development of CRC can contribute to prevention efforts. Methods: Participants from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening trial enrolled in the intervention arm and who completed baseline assessments were included in the analysis (n = 55,685). The DI-GM is a literature-derived index used to score diet quality in terms of maintaining healthy gut microbiota. A time-dependent Cox model …

Association Between The Dietary Index For Gut Microbiota (Di-Gm) And Colorectal Cancer In The Plco Cohort, Bezawit E. Kase, Angela D. Liese, Jiajia Zhang, Elizabeth Angela Murphy, Susan E. Steck

Faculty Publications

Objectives: The study aimed to examine the association between a dietary index for gut microbiota (DI-GM) and the risk of incident colorectal cancer (CRC). Clarifying the role of diet-induced alterations in the composition and function of gut microbiota on the development of CRC can contribute to prevention efforts. Methods: Participants from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening trial enrolled in the intervention arm and who completed baseline assessments were included in the analysis (n = 55,685). The DI-GM is a literature-derived index used to score diet quality in terms of maintaining healthy gut microbiota. A time-dependent Cox model …

Axial Sulfur-Coordination Engineering Boosting Fe–N–C Catalysts For High-Performance Proton Exchange Membrane Fuel Cells, Lin Lin, Xiu-Xuan Hou, Zhe-Chen Fan, Yi-Xuan Yin, Wei-Yi Zhao, Kai Wei, Yu-Die Zhou, Li-Na Hou, Ying Wang, Hao Wan, Jun-Jie Ge

Journal of Electrochemistry

Fe-N-C catalysts have long suffered from kinetically sluggish oxygen reduction reaction (ORR) due to excessive adsorption strength toward oxygen intermediates and low site utilization. Heteroatom doping effectively accelerates ORR reaction kinetics through electronic structure modulation of metal sites for optimal intermediate adsorption, while chemical vapor deposition (CVD) enhances the turnover frequency (TOF) of active sites. Herein, we developed an FeSNC catalyst featuring abundant FeS₁N₄ sites via a dual-precursor CVD strategy. Experimental and theoretical analyses revealed that S incorporation disrupts the symmetric coordination of active sites, which optimizes OH* adsorption energies from 0.212 eV to 1.194 eV. Moreover, …

Deciphering The Role Of Binder Reaction Exothermicity In Thermal Runaway Of Lithium-Ion Cells, Wen Wen, Jing-Hong Zhou, Hao-Tian Lu, Xing-Gui Zhou

Journal of Electrochemistry

Thermal safety associated with lithium-ion cells as power sources remains a critical industry concern. A comprehensive understanding of how internal exothermic side reactions contribute to temperature rise is fundamental for accurately analyzing thermal runaway processes and predicting the thermal safety of lithium-ion cells. While various side-reactions, such as decomposition of solid electrolyte interphase layer, reaction between anode materials and electrolyte, reaction between cathode materials and electrolyte, and electrolyte decomposition, have been identified as heat generation sources in previous studies, the quantification of these reactions remains insufficiently standardized. Particularly, the impact of heat generation from binder decomposition (most commonly polyvinylidene difluoride) …

Entropy Of Metal/Solution Interfaces: Thermodynamic Framework, Theoretical Models, And Roles Of Interfacial Water, Zeng-Ming Zhang, Zi-Xi Liang, Jun Huang

Journal of Electrochemistry

Entropy is a basic thermodynamic property of the electrical double layer (EDL) at metal/solution interfaces, yet, its definition, measurement, and theoretical treatment are dispersed in the literature, and, in some cases, ambiguous. In this paper, we revisit the thermodynamic theory of EDL, from which two variants of entropy, excess entropy and formation entropy, are obtained and compared. In terms of the formation entropy, two calculation routes are validated in the context of a primitive EDL model, namely, the Gouy-Chapman (GC) model. After clarifying the concepts and calculation routes, we investigate interfacial water effects on the EDL entropy, using a refined …

Fabrication And Analysis Of Bi₂O₃/Si Heterojunction For Solar Cell Applications, Maher Khaleel Ibrahim, Assel Mustafa Abdul Majeed, Randa Kamel Husain, Jamal M. Rzaij

Al-Bahir

Bismuth oxide (Bi₂O₃) nanoparticles were synthesized via a green route and integrated into Bi₂O₃/Si heterojunction solar cells. Structural analysis confirmed the monoclinic α-Bi₂O₃ phase with a nanoscale crystallite size, while SEM revealed a uniform morphology. Optical studies showed a direct band gap suitable for absorbing visible light. Photoluminescence spectra exhibited dual emissions at 498 nm and 250 nm, attributed to defect states and quantum confinement, highlighting the dual role of Bi₂O₃ as both absorber and transparent window layer. Electrical characterization under dark conditions demonstrated rectifying diode behavior, confirming the formation of a junction. Capacitance–voltage analysis yielded a built-in potential of …

Norfolk Flooding And Its Effect On Nutrient And Enterococcus Levels, Malachi R. Stephens

Knowledge and Creativity Expo

Tidal flooding is common in the City of Norfolk, VA due to high rates of sea rise in the region, as well as the region’s subsidence. This has led to increases in flooding at high tide, especially during the spring tide portion of the tidal cycle.  At high tide water from the Elizabeth and Lafayette Rivers can flood the landscape directly or can rise out of storm drains. This floodwater often stays on land for long periods of time and can deliver contaminants back into the rivers. To determine the amounts of nutrients and Enterococcus, a fecal indicator, delivered to …

Classification Of Land Cover In Sentinel-2 Imagery Using Machine Learning Models, Ehsan Ali Al-Zubaidi, Mohammed Ridha Hammoodi, Ahmed Naser Alzurfi

Al-Bahir

Remote sensing data of medium resolution are commonly used to classify land cover, and machine learning (ML) models have taken on a central aspect in the necessary data analysis. Ordinarily, land cover is coded on a pixel basis on the basis of Digital Number (DN) values, which in turn are computed across several spectral bands. This paper is concerned with land cover mapping in Mosul, Iraq, based on satellite images captured by Sentinel-2. Two platforms featuring unsupervised classification algorithms were used, Google Earth Engine and ArcMap, making it possible to use K-means and X-means in Google Earth Engine and ISO …

Weakening Relations Over Duals Of Limit Ordinals, Nikolaos Galatos, Isis A. Gallardo

Mathematics: Faculty Scholarship

We prove that all varieties generated by weakening relation algebras over duals of limit ordinals have a decidable equational theory. We also show that there are only countably-many such varieties and they form a chain that embeds in. The time warp algebra is isomorphic to one of these weakening relation algebras (over the dual of the naturals), so we obtain the main result of a recent publication as a special case. The algebras we study connect to the theory of relation algebras, to time warps and graded modalities, and to the algebraic semantics of substructural logics. Our methods are inspired …

Design, Synthesis, And Bioevaluation Of Moxifloxacin Hydrazide Metal Complexes: Integrated Spectroscopic, Computational, Antimicrobial, And Anticancer Investigations, Abbas Mamdoh Abbas, Sara Reda Fisal, Ibrahim A.I. Ali, W. Christropher Boyd, Haitham F. Kalil, Adel Sayed Orabi

Chemistry Faculty Publications

This study reports the synthesis, spectroscopic characterization, and biological evaluation of a novel moxifloxacin hydrazide derivative (MOX-H) and its metal complexes with Co(II), Ni(II), Cu(II), VO(IV), and Gd(III). The ligand was synthesized by hydrazinolysis of moxifloxacin hydrochloride, and the resulting hydrazide was subsequently complexed with the respective metal salts. The interaction between MOX-H and the metal ions yielded the corresponding complexes, formulated as [Co(H2O)Cl(MOX-H)2]Cl & centerdot;2.5H2O, [Ni(H2O)Cl(MOX-H)2]Cl.4.5H2O, [VO(MOX-H)2]SO4.3.5H2O, [Gd (H2O)(MOX-H)2(NO3)2]NO3.2H2O, and [Cu(MOX-H)2(H2O)Cl]Cl & centerdot;xH2O (where x = 2, 2.5, 0.5, for products synthesized via template, microwave-assisted, and hydrothermal methods, respectively). The synthesized analogues were characterized by elemental analysis (CHN), FT-IR, …

Trogs-26 Test Images, Aaron Hershkowitz, Nicholas Howe, Bebe Cosgrove, Tajhini Brown

Data

No abstract provided.

When Ai Writes The Doctoral Thesis: Reclaiming The Oral Defence As A Learning Development Intervention, Valerie A. Storey

All Faculty and Staff Scholarship

Large language models have fundamentally challenged traditional methods of verifying doctoral competency as AI-generated text becomes increasingly difficult to distinguish from human scholarship. This paper argues that thesis committees and doctoral supervisors must reclaim the oral defence as a critical checkpoint for assessing authentic threshold crossing rather than a ceremonial rite of passage. Drawing on historical examples from medieval oral disputations through to the rise of written theses, this paper asserts the necessity of returning to rigorous oral assessment. Given the limitations of detection technologies and the growing use of AI in thesis writing, oral defences must move from confirmatory …

Precision Spectroscopy Of 2s-Ns Transitions In Atomic Hydrogen: A Determination Of The Proton Charge Radius, R. G. Bullis, W. L. Tavis, M. R. Weiss, Orellana O. Cisneros, A. J. Cheeseman, Ulrich D. Jentschura, D. C. Yost

Physics Faculty Research & Creative Works

We present absolute frequency measurements of 2S_1/2-nS_1/2 two-photon transitions with n=8, 9, and 10 in a cryogenic beam of atomic hydrogen. Each transition has been measured with a fractional uncertainty of ≈2.6x10^-12. Combining the results from this Letter and the 1S_1/2-2S_1/2 transition frequency, we extract a root-mean-square proton radius of rp=0.8433(31) fm and a Rydberg frequency of cR_∞=3 289 841 960 252.9(9.7) kHz. These are in good agreement with the CODATA 2022 recommended values.

Chemical Design Strategies For Hybrid Metal Halide Semiconductors With Enhanced Stability And Optoelectronic Properties, Ali Azmy

USF Tampa Graduate Theses and Dissertations

Metal halide semiconductors have rejuvenated the attention of the scientific community for the last two decades owing to their photophysical and electronic properties. However, these materials have some limitations that hinder their commercialization and widespread application. One major limitation of these materials is their instability under ambient and operating conditions of moisture, head, light and radiation exposure. Here, we report multiple chemical design strategies to address the stability issues of these materials while simultaneously maintaining their exceptional optoelectronic properties. Such design strategies allowed the acquisition of the first members of the family of porous metal halide semiconductors which exhibit record …

Riemann-Hilbert Problems For A Class Of Planar Orthogonal Polynomials, Abril Arenas

USF Tampa Graduate Theses and Dissertations

Planar orthogonal polynomials of degree n are monic polynomials defined by the orthogonality relation,

∫cPn(z)Pm(z)e-V(z) dA(z) = hnδn,m.

where the integration is over the whole complex plane with Lebesgue area measure dA, and hn is a positive norming constant. In this thesis we consider the potential V: CR of the type,

V(z) = |z|2p-2Re Σm j=1 tjzj

we characterize the planar orthogonal polynomials using novel matrix Riemann-Hilbert problems. We pro-pose a Riemann-Hilbert problem of size 2px 2p when the maximal degree satisfies m ≤ p. For m = 2p, we propose a Riemann-Hilbert problem of size 3px 3p for the …

New Identities In The Character Table Of Symmetric Groups Involving Riordan Numbers, David J. Hemmer, Armin Straub, Karlee J. Westrem

Michigan Tech Publications

Amdeberhan recently proposed certain equalities between sums in the character table of symmetric groups. These equalities are between signed column sums in the character table, summing over the rows labeled by partitions in Ev(λ), where λ is a partition of n with r nonzero parts and Ev(λ) is a multiset containing 2r partitions of 2n. While we observe that these equalities are not true in general, we prove that they do hold in interesting special cases. These lead to new equalities between sums of degrees of irreducible characters for the symmetric group and a new combinatorial interpretation for the Riordan …

A Study Of Transients From Ground-Based Surveys Reveals New Ultra-Compact Accreting White Dwarf Binaries, Jan Kára, Liliana E. Rivera Sandoval, Wendy Mendoza, Thomas J. Maccarone, Manuel Pichardo Marcano, Luis Salazar Manzano, Ryan J. Oelkers, Jan Van Roestel

Physics & Astronomy Faculty Publications

AM CVn stars are ultra-compact semi-detached binaries consisting of a white dwarf primary and a hydrogen-depleted secondary. In this paper, we present spectroscopic and photometric results of 15 transient sources pre-classified as AM CVn candidates. Our analysis confirms 9 systems of the type AM CVn, 3 hydrogen-rich cataclysmic variables (accreting white dwarfs with near-main-sequence stars for donors), and 3 systems that could be evolved cataclysmic variables. Eight of the AM CVn stars are analysed spectroscopically for the first time, which increases the number of spectroscopically confirmed AM CVns by about 10%. TESS data revealed the orbital period of the AM …

Changes In Land, Ocean, Atmospheric Parameters Associated With The 2025 Myanmar (Mw 7.7) Earthquake, Feng Jing, Akshansa Chauhan, Ashwani Raju, Ramesh P. Singh

Mathematics, Physics, and Computer Science Faculty Articles and Research

Multiple parameters associated with the land, atmosphere, and ocean were analyzed to study short-term and immediate pre-earthquake changes associated with the 28 March 2025 Myanmar earthquake (Mw 7.7). Anomalous clear-sky outgoing longwave radiation (ClrOLR) and trace gases (CH₄, CO, and O₃) were detected within two months prior to the mainshock. Vertical changes at different pressure levels suggest a possible underground source. High-temporal-resolution observations of the infrared brightness temperature and surface air pressure revealed short-lived fluctuations shortly before the earthquake, which may reflect localized stress adjustments and surface latent heat flux release during the final stage of earthquake preparation. In the …

Bridging The Gap: Using Brown Dwarfs To Examine Silicate Clouds In Giant Exoplanet Atmospheres, Emily Calamari, Jacqueline K. Faherty, Channon Visscher, Marina E. Gemma, Austin Rothermich, Francisco Ardévol Martínez, Sherelyn Alejandro Merchan, Genaro Suárez

Faculty Work Comprehensive List

We present results from examining the silicate cloud modeling of four JWST-observed hot Jupiters in the context of brown dwarf theory to further explore signatures of formation in present-day atmospheres. We contextualize our understanding of protoplanetary disk refractory chemistry with empirical evidence from chondritic meteorites to show that giant planets forming and accreting in the outer disk adopt their stellar Mg/Si value. We show that current silicate cloud species determinations of WASP-17 b, WASP-107 b, WASP-39 b, and HD 189733 b are in line with predictions laid out in E. Calamari et al. based on each system’s host star Mg/Si …

2025-2026 - Tennessee Winter Climate Summary, Tennessee Climate Office, East Tennessee State University

Tennessee Climate Office Seasonal and Annual Climate Summaries

No abstract provided.

2026 March 26 - Tennessee Weekly Drought Summary, Tennessee Climate Office, East Tennessee State University

Tennessee Climate Office Weekly Drought Summaries

No abstract provided.

Interview With Orca Award Winner David Hage, Unl Chemistry; Drug-Protein Interactions, Mark Griep, David Hage

UNL ORCA Interview Series

Prof. David Hage was awarded the ORCA in 2018. He was born in La Crosse, Wisconsin, and earned a bachelor’s in chemistry at the University of Wisconsin in La Crosse. Next, he earned a doctorate from Iowa State University and did postdoctoral work at the Mayo Clinic in Rochester, Minnesota. In 1989, he joined UNL as an assistant professor of chemistry and quickly rose through the ranks. He has won many awards and, for the past 13 years, has been the James Hewet University Professor of Chemistry. Allow me to share some remarkable facts about Dave before we get into …