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Full-Text Articles in Physical Sciences and Mathematics

Holocene Chronostratigraphy Of Dune Fields In Southern Utah: Geomorphic Record Of Past Aridity In The Central Colorado Plateau, Harriet S. Cornachione Aug 2022

Holocene Chronostratigraphy Of Dune Fields In Southern Utah: Geomorphic Record Of Past Aridity In The Central Colorado Plateau, Harriet S. Cornachione

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The southwestern United States is characterized by dry climate, and droughts are common. The region is currently in an extreme drought that began in 2000 CE and has lasted longer than any previous drought in at least 500 years. Models predict greater future climate extremes under human-caused climate change. Understanding of the natural range of climate variability is important to put these changes in context. Sedimentary archives of past sand dune activity can help extend the available instrumental observations (last century) and tree-ring records (last millennium).

Sand dunes are landforms that are sensitive to aridity and decreased vegetation cover. They …


Spatiotemporal Data Augmentation Of Modis-Landsat Water Bodies Using Generative Adversarial Networks, Ashit Neema Aug 2022

Spatiotemporal Data Augmentation Of Modis-Landsat Water Bodies Using Generative Adversarial Networks, Ashit Neema

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The monitoring of the shape and area of a water body is an essential component for many Earth science and Hydrological applications. For this purpose, these applications require remote sensing data which provides accurate analysis of the water bodies. In this thesis the same is being attempted, first, a model is created that can map the information from one kind of satellite that captures the data from a distance of 500m to another data that is captured by a different satellite at a distance of 30m. To achieve this, we first collected the data from both of the satellites and …


Using The Reshetikhin-Turaev Link Invariant Approach With Non-Semisimple Categories, Adam Robertson Aug 2022

Using The Reshetikhin-Turaev Link Invariant Approach With Non-Semisimple Categories, Adam Robertson

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Invariants of knots and links are useful because they give rise to invariants of 3-manifolds. In particular, combinatorial link invariants give rise to combinatorial invariants of 3-manifolds, which are hard to come by using traditional methods from classical topology. The Reshetikhin–Turaev approach, which is based in quantum topology, develops link invariants using semisimple ribbon categories. However, a large class of algebraically interesting ribbon categories are non-semisimple and so give trivial link invariants via the Reshetikhin–Turaev method. We modify the Reshetikhin–Turaev method to make it suitable for non-semisimple ribbon categories. We discuss explicitly the following three examples: semisimple modules for the …


Comparing Fecal Dna Capture-Recapture Methods To Traditional Mark-Resight Methods For Estimating Abundance Of Mule Deer On Winter Ranges, Andi M. Stewart Aug 2022

Comparing Fecal Dna Capture-Recapture Methods To Traditional Mark-Resight Methods For Estimating Abundance Of Mule Deer On Winter Ranges, Andi M. Stewart

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Well-designed monitoring strategies are required to obtain accurate estimates of population abundance, which is important for evaluating conservation and management strategies. Obtaining abundance estimates using traditional survey methods, like aerial surveys, is not possible in all scenarios and can be expensive and risky. One survey method that has gained popularity in the last decade is fecal DNA-based capture-recapture (CMR). However, this method has not been evaluated on winter ranges or in snowy, winter conditions.

My first objective was to implement fecal DNA CMR to estimate abundance of mule deer in the Round Valley and Goodale winter survey areas in the …


Conservation Genetics Of A Declining Bumble Bee In Western North America; The Influence Of Geography, Dispersal Limitation, And Anthopogenic Activity, Ashley T. Rohde Aug 2022

Conservation Genetics Of A Declining Bumble Bee In Western North America; The Influence Of Geography, Dispersal Limitation, And Anthopogenic Activity, Ashley T. Rohde

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Conservation biology addresses the problem of species loss by identifying species in need of protection. Conservation biology has subfields to address different aspects of biodiversity loss, including genetics and sociology. I used genetic approaches to assess the conservation status of western bumble bees, a bumble bee species of conservation concern.

The western bumble bee is a bumble bee species that ranges from Alaska to New Mexico and as far east as Wyoming and Colorado. This species is disappearing in some places. It may soon be listed as endangered in the United States and is already listed as endangered in parts …


Redefining Nba Basketball Positions Through Visualization And Mega-Cluster Analysis, Alexander L. Hedquist Aug 2022

Redefining Nba Basketball Positions Through Visualization And Mega-Cluster Analysis, Alexander L. Hedquist

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Basketball players have historically been classified based on one of five positions, namely Point Guards, Shooting Guards, Small Forwards, and Centers. While grouping players into these five categories may provide general descriptions of their perceived role, these standard positions fall short of describing players based on their true abilities and performance. This MS thesis proposes a method to group players of the National Basketball Association (NBA) from the past 20 seasons into more meaningful and specific player positions. We systematically group these players into nine distinct categories, and we draw from a vast array of visualization tools, techniques, and software …


Contributions To Random Forest Variable Importance With Applications In R, Kelvyn K. Bladen Aug 2022

Contributions To Random Forest Variable Importance With Applications In R, Kelvyn K. Bladen

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

A major focus in statistics is building and improving computational algorithms that can use data to predict a response. Two fundamental camps of research arise from such a goal. The first camp is researching ways to get more accurate predictions. Many sophisticated methods, collectively known as machine learning methods, have been developed for this very purpose. One such method that is widely used across industry and many other areas of investigation is called Random Forests.

The second camp of research is that of improving the interpretability of machine learning methods. This is worthy of attention when analysts desire to optimize …


Geometry- And Accuracy-Preserving Random Forest Proximities With Applications, Jake S. Rhodes Aug 2022

Geometry- And Accuracy-Preserving Random Forest Proximities With Applications, Jake S. Rhodes

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Many machine learning algorithms use calculated distances or similarities between data observations to make predictions, cluster similar data, visualize patterns, or generally explore the data. Most distances or similarity measures do not incorporate known data labels and are thus considered unsupervised. Supervised methods for measuring distance exist which incorporate data labels and thereby exaggerate separation between data points of different classes. This approach tends to distort the natural structure of the data. Instead of following similar approaches, we leverage a popular algorithm used for making data-driven predictions, known as random forests, to naturally incorporate data labels into similarity measures known …


The History Of Air Quality In Utah: A Narrative Review, Logan E. Mitchell, Christopher Zajchowski Aug 2022

The History Of Air Quality In Utah: A Narrative Review, Logan E. Mitchell, Christopher Zajchowski

Human Movement Studies & Special Education Faculty Publications

Utah has a rich history related to air pollution; however, it is not widely known or documented. This is despite air quality being a top issue of public concern for the state’s urban residents and acute episodes that feature some of the world’s worst short-term particulate matter exposure. As we discuss in this narrative review, the relationship between air pollution and the state’s residents has changed over time, as fuel sources shifted from wood to coal to petroleum and natural gas. Air pollution rose in prominence as a public issue in the 1880s as Utah’s urban areas grew. Since then, …


Saturation And Periodic Self-Stress In Geometric Auxetics, Ciprian S. Borcea, Ileana Streinu Aug 2022

Saturation And Periodic Self-Stress In Geometric Auxetics, Ciprian S. Borcea, Ileana Streinu

Computer Science: Faculty Publications

The auxetic structures considered in this paper are three-dimensional periodic bar-and-joint frameworks. We start with the specific purpose of obtaining an auxetic design with underlying periodic graph of low valency. Adapting a general methodology, we produce an initial framework with valency seven and one degree of freedom. Then, we describe a saturation process, whereby edge orbits are added up to valency 16, with no alteration of the deformation path. This is reflected in a large dimension for the space of periodic self-stresses. The saturated version has higher crystallographic symmetry and allows a precise description of the deformation trajectory. Reducing saturation …


Fake News Detection On Social Media: A Word Embedding-Based Approach, Muammer Eren Sahin, Chunyang Tang, Mohammad A. Al-Ramahi Aug 2022

Fake News Detection On Social Media: A Word Embedding-Based Approach, Muammer Eren Sahin, Chunyang Tang, Mohammad A. Al-Ramahi

Computer Information Systems Faculty Publications (Archived)

The rapid development of social media, together with the large number of user-generated content on them, has not only connected an unprecedented number of people together to do good stuff, but also has provided convenient platforms to spread misleading pieces of information such as fake news. Existing research has attempted to leverage machine learning to automatically classify fake news. In this paper, we extend such literature by proposing an approach that utilize word embedding and Long Short-Term Memory (LSTM) neural network algorithm. Unlike existing studies, we used two publicly available datasets of news articles to evaluate the proposed model. The …


Latitudinal Variance In The Drivers And Pacing Of Warmth During Mid-Pleistocene Mis 31 In The Antarctic Zone Of The Southern Ocean, Jonathan P. Warnock, Brendan T. Reilly, Maureen E. Raymo, Michael E. Weber, Victoria Peck, Trevor Williams, Linda Armbrecht, Ian Bailey, Stefanie Brachfeld, Zhiheng Du, Gerson Fauth, Marga M. García, Anna Glüder, Michelle Guitard, Marcus Gutjahr, Sidney Hemming, Iván Hernández-Almeida, Freida S. Hoem, Ji Hwan Hwang, Mutsumi Iizuka, Yuji Kato, Bridget Lee, Yasmina M. Martos, Suzanne O’Connell, Lara F. Pérez, Thomas A. Ronge, Osamu Seki, Lisa Tauxe, Shubham Tripathi, Xufeng Zheng, Joseph Stoner, Reed P. Scherer Aug 2022

Latitudinal Variance In The Drivers And Pacing Of Warmth During Mid-Pleistocene Mis 31 In The Antarctic Zone Of The Southern Ocean, Jonathan P. Warnock, Brendan T. Reilly, Maureen E. Raymo, Michael E. Weber, Victoria Peck, Trevor Williams, Linda Armbrecht, Ian Bailey, Stefanie Brachfeld, Zhiheng Du, Gerson Fauth, Marga M. García, Anna Glüder, Michelle Guitard, Marcus Gutjahr, Sidney Hemming, Iván Hernández-Almeida, Freida S. Hoem, Ji Hwan Hwang, Mutsumi Iizuka, Yuji Kato, Bridget Lee, Yasmina M. Martos, Suzanne O’Connell, Lara F. Pérez, Thomas A. Ronge, Osamu Seki, Lisa Tauxe, Shubham Tripathi, Xufeng Zheng, Joseph Stoner, Reed P. Scherer

Department of Earth and Environmental Studies Faculty Scholarship and Creative Works

Early Pleistocene Marine Isotope Stage (MIS)-31 (1.081–1.062 Ma) is a unique interval of extreme global warming, including evidence of a West Antarctic Ice Sheet (WAIS) collapse. Here we present a new 1,000-year resolution, spanning 1.110–1.030 Ma, diatom-based reconstruction of primary productivity, relative sea surface temperature changes, sea-ice proximity/open ocean conditions and diatom species absolute abundances during MIS-31, from the Scotia Sea (59°S) using deep-sea sediments collected during International Ocean Discovery Program (IODP) Expedition 382. The lower Jaramillo magnetic reversal (base of C1r.1n, 1.071 Ma) provides a robust and independent time-stratigraphic marker to correlate records from other drill cores in the …


Fermion-Induced Electroweak Symmetry Non-Restoration Via Temperature-Dependent Masses, Yu Hang Ng Aug 2022

Fermion-Induced Electroweak Symmetry Non-Restoration Via Temperature-Dependent Masses, Yu Hang Ng

Department of Physics and Astronomy: Dissertations, Theses, and Student Research

Standard Model (SM) and many extensions of SM predict that the electroweak (EW) symmetry was restored in the early universe when the temperature was around 160 GeV. However, recent studies showed that the interactions between some new scalars and SU(2)_L Higgs doublet(s) can cause the EW symmetry to remain broken at temperatures well above the EW scale in certain renormalizable extensions of SM. In this study, we found that new fermions from renormalizable models can also induce this EW symmetry non-restoration effect, provided that they have the appropriate temperature-dependent masses. These masses can arise naturally from the interactions between the …


Investigation Of Transport Behavior In Two-Dimensional Ferroelectric Heterostructures, Pradeep Chaudhary Aug 2022

Investigation Of Transport Behavior In Two-Dimensional Ferroelectric Heterostructures, Pradeep Chaudhary

Department of Physics and Astronomy: Dissertations, Theses, and Student Research

This dissertation summarizes an investigation of the polarization-related electronic transport behavior in the ferroelectric thin films and two-dimensional (2D) materials heterostructures using Scanning Probe Microscopy (SPM) techniques.

The polarization-related resistive switching in hafnium oxide thin films-based ferroelectric tunnel junction has been demonstrated by employing semiconducting MoS2 as a top electrode. We explored a coupling between the semiconducting properties of MoS2 and the polarization of Hf0.5Zr0.5O2 resulted in an enhanced tunneling electroresistance effect of up to 3 orders of magnitude. These results provide a possible pathway for the fabrication of …


Nanoscale Studies Of The Ferroelectric And Electromechanical Properties Of Hafnia-Based Capacitors, Pratyush Buragohain Aug 2022

Nanoscale Studies Of The Ferroelectric And Electromechanical Properties Of Hafnia-Based Capacitors, Pratyush Buragohain

Department of Physics and Astronomy: Dissertations, Theses, and Student Research

The work presented in this dissertation aims to provide nanoscopic insights into the electrical and electromechanical behavior of the recently discovered ferroelectric HfO2 or hafnia-based capacitors. Hafnia-based ferroelectrics are highly promising for technological applications due to compatibility with the existing Si technology. To realize the full potential of hafnia, however, requires comprehensive understanding of its properties. In this regard, this dissertation hopes to bridge a gap between an understanding of the nanoscopic and macroscopic properties of hafnia by performing combined high-resolution piezoresponse force microscopy (PFM) and pulse switching studies.

More specifically, the dynamics of domain nucleation and wall motion …


Causal Forest Approach For Site-Specific Input Management Via On-Farm Precision Experimentation, Shunkei Kakimoto Aug 2022

Causal Forest Approach For Site-Specific Input Management Via On-Farm Precision Experimentation, Shunkei Kakimoto

Department of Agricultural Economics: Dissertations, Theses, and Student Research

Estimating site-specific crop yield response to changes to input (e.g., seed, fertilizer) management is a critical step in making economically optimal site-specific input management recommendations. Past studies have attempted to estimate yield response functions using various Machine Learning (ML) methods, including the Random Forest (RF), Boosted Random Forest (BRF), and Convolutional Neural Network (CNN) methods. This study proposes use of the Causal Forest (CF) model, which is one of the emerging ML methods that comprise “Causal Machine Learning.” Unlike previous yield-prediction-oriented ML methods, CF focuses strictly on estimating heterogeneous treatment effects (changes in yields that result from changes in input …


Assessment Of Nitrogen-Based Fertilizer Transport And Microbial Activities In Sandy Soil Profiles In South Texas, Gladys De La Rosa Aug 2022

Assessment Of Nitrogen-Based Fertilizer Transport And Microbial Activities In Sandy Soil Profiles In South Texas, Gladys De La Rosa

Theses and Dissertations

Conventional farming is a common practice in Lower Rio Grande Valley (LRGV) and the application of nitrogen fertilizer is essential for plant growth and support. However, managing the rate of nitrogen that is applied can benefit farmers financially and reduce nitrate leaching that can have an adverse effect on the local environment and aquatic systems, e.g., rivers and estuaries. Sandy soils are more vulnerable to water infiltration due to the large proportion of macropores. This study aims to (i) assess how nitrate from a variety of fertilizers (i.e., synthetic and organic) distributes on the top 60 cm layer of a …


Bridge Trisections And Classical Knotted Surface Theory, Jason Joseph, Jeffrey Meier, Maggie Miller, Miller Zupan Aug 2022

Bridge Trisections And Classical Knotted Surface Theory, Jason Joseph, Jeffrey Meier, Maggie Miller, Miller Zupan

Department of Mathematics: Faculty Publications

We seek to connect ideas in the theory of bridge trisections with other wellstudied facets of classical knotted surface theory. First, we show how the normal Euler number can be computed from a tri-plane diagram, and we use this to give a trisection-theoretic proof of the Whitney–Massey theorem, which bounds the possible values of this number in terms of the Euler characteristic. Second, we describe in detail how to compute the fundamental group and related invariants from a tri-plane diagram, and we use this, together with an analysis of bridge trisections of ribbon surfaces, to produce an infinite family of …


Feature Analysis Of Indus Valley And Dravidian Language Scripts With Similarity Matrices, Sarat Sasank Barla, Sai Surya Sanjay Alamuru, Peter Revesz Aug 2022

Feature Analysis Of Indus Valley And Dravidian Language Scripts With Similarity Matrices, Sarat Sasank Barla, Sai Surya Sanjay Alamuru, Peter Revesz

School of Computing: Conference and Workshop Papers

This paper investigates the similarity between the Indus Valley script and the Kannada, Malayalam, Tamil, and Telugu scripts that are used to write Dravidian languages. The closeness of these scripts is determined by applying a feature analysis of each sign of these scripts and creating similarity matrices that describe the similarity of any pair of signs from two different scripts. The feature list that we use for the analysis of these Dravidian language-related scripts includes six new features beyond the thirteen features that were used for the study of Minoan Linear A and related scripts by Revesz. These new features …


Computer Aided Diagnosis System For Breast Cancer Using Deep Learning., Asma Baccouche Aug 2022

Computer Aided Diagnosis System For Breast Cancer Using Deep Learning., Asma Baccouche

Electronic Theses and Dissertations

The recent rise of big data technology surrounding the electronic systems and developed toolkits gave birth to new promises for Artificial Intelligence (AI). With the continuous use of data-centric systems and machines in our lives, such as social media, surveys, emails, reports, etc., there is no doubt that data has gained the center of attention by scientists and motivated them to provide more decision-making and operational support systems across multiple domains. With the recent breakthroughs in artificial intelligence, the use of machine learning and deep learning models have achieved remarkable advances in computer vision, ecommerce, cybersecurity, and healthcare. Particularly, numerous …


Role Of Deep Learning Techniques In Non-Invasive Diagnosis Of Human Diseases., Hisham Abouelseoud Elsayem Abdeltawab Aug 2022

Role Of Deep Learning Techniques In Non-Invasive Diagnosis Of Human Diseases., Hisham Abouelseoud Elsayem Abdeltawab

Electronic Theses and Dissertations

Machine learning, a sub-discipline in the domain of artificial intelligence, concentrates on algorithms able to learn and/or adapt their structure (e.g., parameters) based on a set of observed data. The adaptation is performed by optimizing over a cost function. Machine learning obtained a great attention in the biomedical community because it offers a promise for improving sensitivity and/or specificity of detection and diagnosis of diseases. It also can increase objectivity of the decision making, decrease the time and effort on health care professionals during the process of disease detection and diagnosis. The potential impact of machine learning is greater than …


Alkylthiocarbamate Metal Complexes With Antiproliferation Activity., Kritika Bajaj Aug 2022

Alkylthiocarbamate Metal Complexes With Antiproliferation Activity., Kritika Bajaj

Electronic Theses and Dissertations

Bis(thiosemicarbazones) (BTSCs) and their metal complexes have been extensively studied for various applications including catalysis for hydrogen evolution reactions, treatment of neurodegenerative diseases, hypoxia imaging, and a wide range of pharmacological purposes including antitumor, antiviral, antibacterial, and antifungal agents. The paramount property that makes BTSC metal complexes interesting for their use in these applications is the reduction potential of the coordinated metal, which can be selectively tuned by varying the substituents present on the ligand framework. Although the BTSCs have shown a great deal of success as potential cancer therapeutic agents, they lack selectivity towards cancer cells. For this matter, …


Dimension And Ramsey Results In Partially Ordered Sets., Sida Wan Aug 2022

Dimension And Ramsey Results In Partially Ordered Sets., Sida Wan

Electronic Theses and Dissertations

In this dissertation, there are two major parts. One is the dimension results on different classes of partially ordered sets. We developed new tools and theorems to solve the bounds on interval orders using different number of lengths. We also discussed the dimension of interval orders that have a representation with interval lengths in a certain range. We further discussed the interval dimension and semi dimension for posets. In the second part, we discussed several related results on the Ramsey theory of grids, the results involve the application of Product Ramsey Theorem and Partition Ramsey Theorem


A New Sir Model With Mobility., Ciana Applegate Aug 2022

A New Sir Model With Mobility., Ciana Applegate

Electronic Theses and Dissertations

In this paper, a mobility-based SIR model is built to understand the spread of the pandemic. A traditional SIR model used in epidemiology describes the transition of particles among states, such as susceptible, infected, and recovered states. However, the traditional model has no movement of particles. There are many variations of SIR models when it comes to the factor of mobility, the majority of studies use mobility intensity or population density as a measure of mobility. In this paper, a new dynamical SIR model, including the spatial motion of three-type particles, is constructed and the long-time behavior of the first …


Cross-Validation For Autoregressive Models., Christina Han Aug 2022

Cross-Validation For Autoregressive Models., Christina Han

Electronic Theses and Dissertations

There are no set rules for choosing the lag order for autoregressive (AR) time series models. Currently, the most common methods employ AIC or BIC. However, AIC has been proven to be inconsistent and BIC is inefficient. Racine proposed an estimator based on Shao's work which he hypothesized would also be consistent, but left the proof as an open problem. We will show his claim does not follow immediately from Shao. However, Shao offered another consistent method for cross validation of linear models called APCV, and we will show that AR models satisfy Shao's conditions. Thus, APCV is a consistent …


Estimating The Health Effects Of Adding Bicycle And Pedestrian Paths At The Census Tract Level: Multiple Model Comparison, Ross J. Gore, Christopher Lynch, Craig Jordan, Andrew Collins, R. Michael Robinson, Gabrielle Fuller, Pearson Ames, Prateek Keerthi, Yash Kandukuri Aug 2022

Estimating The Health Effects Of Adding Bicycle And Pedestrian Paths At The Census Tract Level: Multiple Model Comparison, Ross J. Gore, Christopher Lynch, Craig Jordan, Andrew Collins, R. Michael Robinson, Gabrielle Fuller, Pearson Ames, Prateek Keerthi, Yash Kandukuri

VMASC Publications

Background: Adding additional bicycle and pedestrian paths to an area can lead to improved health outcomes for residents over time. However, quantitatively determining which areas benefit more from bicycle and pedestrian paths, how many miles of bicycle and pedestrian paths are needed, and the health outcomes that may be most improved remain open questions.

Objective: Our work provides and evaluates a methodology that offers actionable insight for city-level planners, public health officials, and decision makers tasked with the question “To what extent will adding specified bicycle and pedestrian path mileage to a census tract improve residents’ health outcomes over time?” …


Adaptive Risk Network Dependency Analysis Of Complex Hierarchical Systems, Katherine L. Smith Aug 2022

Adaptive Risk Network Dependency Analysis Of Complex Hierarchical Systems, Katherine L. Smith

Computational Modeling & Simulation Engineering Theses & Dissertations

Recently the number, variety, and complexity of interconnected systems have been increasing while the resources available to increase resilience of those systems have been decreasing. Therefore, it has become increasingly important to quantify the effects of risks and the resulting disruptions over time as they ripple through networks of systems. This dissertation presents a novel modeling and simulation methodology which quantifies resilience, as impact on performance over time, and risk, as the impact of probabilistic disruptions. This work includes four major contributions over the state-of-the-art which are: (1) cyclic dependencies are captured by separation of performance variables into layers which …


Inexact Fixed-Point Proximity Algorithms For Nonsmooth Convex Optimization, Jin Ren Aug 2022

Inexact Fixed-Point Proximity Algorithms For Nonsmooth Convex Optimization, Jin Ren

Mathematics & Statistics Theses & Dissertations

The aim of this dissertation is to develop efficient inexact fixed-point proximity algorithms with convergence guaranteed for nonsmooth convex optimization problems encountered in data science. Nonsmooth convex optimization is one of the core methodologies in data science to acquire knowledge from real-world data and has wide applications in various fields, including signal/image processing, machine learning and distributed computing. In particular, in the context of image reconstruction, compressed sensing and sparse machine learning, either the objective functions or the constraints of the modeling optimization problems are nondifferentiable. Hence, traditional methods such as the gradient descent method and the Newton method are …


Design, Synthesis And Characterization Of Triazole Based Glycoconjugates And 4,6-Acetal Protected D-Glucosamine Derivatives As Low Molecular Weight Gelators, Pooja Sharma Aug 2022

Design, Synthesis And Characterization Of Triazole Based Glycoconjugates And 4,6-Acetal Protected D-Glucosamine Derivatives As Low Molecular Weight Gelators, Pooja Sharma

Chemistry & Biochemistry Theses & Dissertations

Low molecular weight gelators (LMWGs) are small molecules that can form gels in either organic solvents or water in their pure form or as mixtures. LMWGs self-assemble through noncovalent interactions such as hydrogen bonding, halogen bonding, van der Waals interactions and hydrophobic forces in solvents. They have shown great potential in biomedical industry, catalysis and environmental remediation to name a few. Moreover, the formation of metallogels can be used for detection of various ions as well as catalysis, which adds a new dimension to their applications. Among many classes of LMWGs based on the type of functional groups used, carbohydrate …


Kinetic And Structural Characterization Of Pseudooxynicotine Amine Oxidase From Pseudomonas Putida S16, Vishakha Choudhary Aug 2022

Kinetic And Structural Characterization Of Pseudooxynicotine Amine Oxidase From Pseudomonas Putida S16, Vishakha Choudhary

Masters Theses

Our laboratory has previously shown that nicotine oxidoreductase (NicA2), a member of the flavin-containing amine oxidase family, uses a cytochrome c protein (CycN) as its electron acceptor rather than characteristically accepted molecular oxygen. Within the Pseudomonas putida S16 genome, the nicA2 gene forms an operon with cycN and pseudooxynicotine amine oxidase (pnao), another flavin containing amine oxidase enzyme. The first two steps in the nicotine catabolism pathway are catabolized by NicA2 and Pnao. Through redox chemistry, NicA2 converts nicotine to pseudooxynicotine and Pnao converts pseudooxynicotine to 3-succinoylsemialdehyde-pyridine. In this thesis, we characterize the kinetic and structural properties of …