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Full-Text Articles in Physical Sciences and Mathematics

El Niño And The Human-Environment Nexus: Drought And Vulnerability In Singapore 1877-1911, Fiona Williamson Aug 2022

El Niño And The Human-Environment Nexus: Drought And Vulnerability In Singapore 1877-1911, Fiona Williamson

Research Collection College of Integrative Studies

This chapter brings a climatic perspective to the study of Singaporean history by exploring the impacts of the strong El Niño inspired droughts of 1877, 1902 and 1911. The narrative focuses on unpacking the nexus of nature-inspired versus human-induced vulnerability to drought within the contexts of colonial urbanisation and looks at the short-to medium-term impacts of the events on society. It also explores how such events inspired new questions about the climate and regional teleconnections, as a wealth of evidence became available due to the increasingly connected nature of scientific institutions, scientific literature, and communications systems across the Indian Ocean …


Integrated Assessment Of Urban Overheating Impacts On Human Life, N. Nazarian, E. S. Krayenhoff, B. Bechtel, D. M. Hondula, R. Paolini, J. Vanos, T. Cheung, Winston T. L. Chow, Et Al Aug 2022

Integrated Assessment Of Urban Overheating Impacts On Human Life, N. Nazarian, E. S. Krayenhoff, B. Bechtel, D. M. Hondula, R. Paolini, J. Vanos, T. Cheung, Winston T. L. Chow, Et Al

Research Collection College of Integrative Studies

Urban overheating, driven by global climate change and urban development, is a major contemporary challenge that substantially impacts urban livability and sustainability. Overheating represents a multifaceted threat to the well-being, performance, and health of individuals as well as the energy efficiency and economy of cities, and it is influenced by complex interactions between building, city, and global scale climates. In recent decades, extensive discipline-specific research has characterized urban heat and assessed its implications on human life, including ongoing efforts to bridge neighboring disciplines. The research horizon now encompasses complex problems involving a wide range of disciplines, and therefore comprehensive and …


Visualizing Bivariate Statistics Using Ellipses Over A Scatter Plot, Mamunur Rashid, Jyotirmoy Sarkar, Siddhanta Phuyal Aug 2022

Visualizing Bivariate Statistics Using Ellipses Over A Scatter Plot, Mamunur Rashid, Jyotirmoy Sarkar, Siddhanta Phuyal

Mathematics Faculty Publications

A scatter plot shows the relationship between two quantitative variables 𝒙 and 𝒚. Sometimes, we can predict one variable as a linear function of the other using the least squares regression lines of 𝒚 on 𝒙 or 𝒙 on 𝒚. These two regression lines together suffice to identify the mean vector, the coefficient of determination, the correlation coefficient, and the ratio of the standard deviations (SD). So, do our proposed summary ellipses. Additionally, the inner ellipse reveals the SDs and the outer ellipse flags potential outliers.


Estimating The Parameters Of A Simple Linear Regression Model Without Using Differential Calculus, Mamunur Rashid, Jyotirmoy Sarkar Aug 2022

Estimating The Parameters Of A Simple Linear Regression Model Without Using Differential Calculus, Mamunur Rashid, Jyotirmoy Sarkar

Mathematics Faculty Publications

To estimate the parameters of a simple linear regression model, students who already know calculus can minimize the total squared deviations by setting its first-order partial derivatives to zero and solving simultaneously. For students who do not know calculus, most teachers/textbooks simply state the formulas without justifying them. Students accept the formulas on faith; and for given data, they evaluate the estimates using a calculator or a statistical software. In this paper, we justify the formulas without invoking calculus. We hope the users of statistics will benefit from our proposed justifications.


Semiparametric Estimation With Clustered Right Censored Data Via Multivariate Gaussian Random Fields, Fathima Zahra Sainul Abdeen Aug 2022

Semiparametric Estimation With Clustered Right Censored Data Via Multivariate Gaussian Random Fields, Fathima Zahra Sainul Abdeen

Doctoral Dissertations

Consider a fixed number of clustered areas identified by their geographical coordinate that are monitored for the occurrences of an event such as pandemic, epidemic, migration to name a few. Data collected on units at all areas include time varying covariates and other environmental factors that may affect event occurrences. The event times in every area can be independent. They can also be correlated with correlation between two units induced by an unobservable frailty. In both cases, the collected data is considered pairwise to account for spatial correlation between all pair of areas. The pairwise right censored data is probit-transformed …


An Integral Transform For Quantum Amplitudes, Jack C. Straton Aug 2022

An Integral Transform For Quantum Amplitudes, Jack C. Straton

Physics Faculty Publications and Presentations

The central impediment to reducing multidimensional integrals of transition amplitudes to analytic form, or at least to a fewer number of integral dimensions, is the presence of magnitudes of coordinate vector differences (square roots of polynomials) |x1−x2|2=x21−2x1x2cosθ+x2 √ in disjoint products of functions. Fourier transforms circumvent this by introducing a three-dimensional momentum integral for each of those products, followed in many cases by another set of integral transforms to move all of the resulting denominators into a single quadratic form in one denominator whose square my be completed. Gaussian transforms introduce a one-dimensional integral for each such product while squaring …


Secrep : A Framework For Automating The Extraction And Prioritization Of Security Requirements Using Machine Learning And Nlp Techniques, Shada Khanneh Aug 2022

Secrep : A Framework For Automating The Extraction And Prioritization Of Security Requirements Using Machine Learning And Nlp Techniques, Shada Khanneh

Theses, Dissertations and Culminating Projects

Gathering and extracting security requirements adequately requires extensive effort, experience, and time, as large amounts of data need to be analyzed. While many manual and academic approaches have been developed to tackle the discipline of Security Requirements Engineering (SRE), a need still exists for automating the SRE process. This need stems mainly from the difficult, error-prone, and time-consuming nature of traditional and manual frameworks. Machine learning techniques have been widely used to facilitate and automate the extraction of useful information from software requirements documents and artifacts. Such approaches can be utilized to yield beneficial results in automating the process of …


Investigating Elementary School Students’ Reasoning About Dynamic Angles, Erell Germia Aug 2022

Investigating Elementary School Students’ Reasoning About Dynamic Angles, Erell Germia

Theses, Dissertations and Culminating Projects

Angle measurement is a significant topic in almost all areas of mathematics learning and also in many disciplines outside mathematics education, such as engineering and architecture. According to the literature, there are three common conceptions of angles – as union of rays, rotations, and wedges. Researchers argued that students must consider these three angle concepts together to construct a meaningful understanding of angles. However, the curriculum standards for mathematics often present these angle conceptions separately to students, probably resulting in a fragmented understanding of the angle concept. In addition to this problem, the research literature documents multiple alternative conceptions that …


Secure Retrieval Of Encrypted Similar Documents Using Bloom Filters, German Guzman Aug 2022

Secure Retrieval Of Encrypted Similar Documents Using Bloom Filters, German Guzman

Theses, Dissertations and Culminating Projects

The ability to search for similar documents is a well-known problem on the Web and Information Retrieval field. For example, identifying similar profiles across different government agencies is an important process during intelligence gathering. Nonetheless, when data belongs to multiple parties, internal security policies and government regulations cannot allow the participating parties to freely share their sensitive documents. In our project, we aim to address the following problem: Given a user’s query Q and an encrypted database of documents stored on a third-party cloud server, we want to retrieve top-k documents similar to Q without disclosing Q and the contents …


Conservation Of Open-Canopy-Associated Wildlife: Multi-Scale Management Impacts On Imperiled Herpetofauna, Ethan Joseph Royal Aug 2022

Conservation Of Open-Canopy-Associated Wildlife: Multi-Scale Management Impacts On Imperiled Herpetofauna, Ethan Joseph Royal

Graduate Theses and Dissertations

The loss of open-canopy ecosystems throughout North America has precipitated declines in reptile and amphibian species associated with these habitat types. Current efforts to restore open-canopy ecosystems are underway in many areas, but the local distributions of, habitat characteristics required by and the effects of management actions on many herpetofauna species are poorly understood or entirely unknown. Research examining relationships among herpetofauna and their environments is often complicated by the extremely low detectability seen in many studies. We used landscape-scale, assemblage-level surveys to investigate the occupancy patterns and habitat associations of open-canopy-associated herpetofauna in two regions, as well as gain …


Weakly Q-Convex Domains And Bounded Q-Subharmonic Exhaustion Functions, Emily Foss Aug 2022

Weakly Q-Convex Domains And Bounded Q-Subharmonic Exhaustion Functions, Emily Foss

Graduate Theses and Dissertations

We generalize the Diederich-Fornaess index to bounded weakly q-convex domains with bounded q-subharmonic exhaustion functions. Sufficient conditions for this generalized Diederich-Fornæss index to have a given lower bound are proved. We show this generalized index is positive on bounded weakly q-convex domains with C^3 boundaries. Additionally, we prove sufficient conditions for this generalized index to equal one. For example, we show that if the domain has Property ( ̃(Pq ) ) then the domain has high hyperconvexity.


Structural Interpretation Of An Alkaline-Carbonatite Complex Using Gravity And Magnetic Methods At Magnet Cove, Arkansas, Chelsea Morgan Amaral Aug 2022

Structural Interpretation Of An Alkaline-Carbonatite Complex Using Gravity And Magnetic Methods At Magnet Cove, Arkansas, Chelsea Morgan Amaral

Graduate Theses and Dissertations

The Magnet Cove alkaline-carbonatite complex in the Ouachita Mountains of south-central Arkansas could be a valuable resource for rare earth elements, though it has not yet been thoroughly studied using geophysical methods, and existing geophysical models simplify its diverse nature. Prior to this study, the subsurface structure and extent of the Magnet Cove complex was poorly understood and, in general, the process of emplacement of alkaline carbonatite complexes worldwide is also not fully understood. The Magnet Cove complex hosts an extensive variety of rare rock types and mineral resources that contrast significantly to the sedimentary rocks into which they have …


Quantum Transport And Electric-Field Effects In Layered Topological Semimetals And Magnetic Materials, Arash Fereidouni Ghaleh Minab Aug 2022

Quantum Transport And Electric-Field Effects In Layered Topological Semimetals And Magnetic Materials, Arash Fereidouni Ghaleh Minab

Graduate Theses and Dissertations

This dissertation describes transport experiments on quantum devices in layered Dirac nodal line topological semimetals and antiferromagnetic materials down to a few layers. We used gate-induced effects to alter the transport properties of these materials.

First, we introduced current annealing in topological semimetals to achieve high-quality devices. We demonstrate current annealing to substantially improve the electronic transport properties of 2D topological semimetal flakes. Contact resistance and resistivity were improved by factors up to 2,000,000 and 20,000, respectively, in devices based on exfoliated flakes of two topological semimetals, ZrSiSe and BaMnSb2. Using this method, carrier mobility in ZrSiSe improved by a …


The Cosmic History Of X-Ray Binary Evolution, Woodrow Gilbertson Aug 2022

The Cosmic History Of X-Ray Binary Evolution, Woodrow Gilbertson

Graduate Theses and Dissertations

The Chandra Deep Fields provide an extraordinary window into the high-energy history of the cosmos. Observations of non-active galaxies within the deep fields can be leveraged to extract information about the formation and evolution of X-ray binaries (XRBs). Previous studies have suggested that the evolution of XRB luminosity can be expressed a function of physical parameters such as star formation rate, stellar mass, stellar age, and metallicity. The goal of this work is to develop and implement a complete physical parameterization for the luminosity of XRB populations, which can be utilized for a variety of further studies.

Chapter 1 provides …


Evaluation Of Carbon Isotopic Chemostratigraphy Of The Cedar Mountain Formation Of Utah, Clayton Forster Aug 2022

Evaluation Of Carbon Isotopic Chemostratigraphy Of The Cedar Mountain Formation Of Utah, Clayton Forster

Graduate Theses and Dissertations

The Lower Cretaceous rocks of Utah preserve the origin of a multitude of dinosaur taxa, spread of angiosperms on the North American continent, and evolution of marsupial and eutherian mammals. However, the timing of deposition of these rocks is not well understood and must be determined to understand climatic controls on these biological events. Estimates of the age of the Cedar Mountain Formation and its constituent members range from Late Jurassic to early Late Cretaceous. Understanding the timing of deposition of the Cedar Mountain Formation is critical to dinosaurian and associated taxa studies as well as paleoclimate reconstructions from within …


Understanding Martian Salts And Their Implications For Liquid Water, Rachel Slank Aug 2022

Understanding Martian Salts And Their Implications For Liquid Water, Rachel Slank

Graduate Theses and Dissertations

Water is one of the key components for life as we know it. The existence of salts on Mars has been a large contributing factor to the possibility of habitability, due to their ability to allow liquid water to remain stable at colder temperatures. Salts, including perchlorates, chlorates, and chlorides, have been detected by multiple landers, rovers, and orbiters, and are now believed to be ubiquitous on Mars. One of the pathways to liquid brine solutions is through deliquescence. Deliquescence is the transition from a solid salt crystal into an aqueous solution when exposed to a humid atmosphere. This research …


Study Of Thermoelectric And Lattice Dynamics Properties Of 2d Layered Mx (M = Sn, Pb; X = S, Se, Te) And Zrs2 Compounds Using First-Principles Approach, Abhiyan Pandit Aug 2022

Study Of Thermoelectric And Lattice Dynamics Properties Of 2d Layered Mx (M = Sn, Pb; X = S, Se, Te) And Zrs2 Compounds Using First-Principles Approach, Abhiyan Pandit

Graduate Theses and Dissertations

The aim of this dissertation is the investigation of thermoelectric and lattice dynamics properties of two-dimensional (2D) MX (M = Sn, Pb; X = S, Se, Te) and ZrS2 compounds based on the first-principles density functional theory. The dimensionality reduction (e.g., using 2D structure) of bulk materials is found to have enhanced thermoelectric efficiency. This enhancement is attributed to the increase of the Seebeck coefficient as a result of higher electronic density of states near the Fermi level in low-dimensional materials. In addition, lowering the dimensionality increases phonon scattering near interfaces and surfaces in 2D materials, which leads to a …


Materials Design For Energy Applications Using Ab- Initio Calculations, Hind Hemaidee Alqurashi Aug 2022

Materials Design For Energy Applications Using Ab- Initio Calculations, Hind Hemaidee Alqurashi

Graduate Theses and Dissertations

The structural, dynamical, electronic, and thermoelectric properties of rock-salt and wurtzite Cd1-xZnxO alloys, VTiRhZ (Al, Ga, In, Si, Ge, Sn) and ZrTiRhZ (Ge, Sn) quaternary Heusler alloys (QHAs) were investigated using density functional theory (DFT) and semi-classical Boltzmann transport theory. From these calculations, the alloys were identified as potential materials for future thermoelectric applications. Furthermore, the magnetic and spin-polarization properties of these QHAs were investigated. The total magnetic moments were found to be integer values for all QHAs. In addition, all studied QHAs except VTiRhAl possess a half-metallic behavior with a 100% spin-polarization. The half-metallic ferromagnetic behavior makes them promising …


The Effects Of Side-Channel Attacks On Post-Quantum Cryptography: Influencing Frodokem Key Generation Using The Rowhammer Exploit, Michael Jacob Fahr Aug 2022

The Effects Of Side-Channel Attacks On Post-Quantum Cryptography: Influencing Frodokem Key Generation Using The Rowhammer Exploit, Michael Jacob Fahr

Graduate Theses and Dissertations

Modern cryptographic algorithms such as AES and RSA are effectively used for securing data transmission. However, advancements in quantum computing pose a threat to modern cryptography algorithms due to the potential of solving hard mathematical problems faster than conventional computers. Thus, to prepare for quantum computing, NIST has started a competition to standardize quantum-resistant public-key cryptography algorithms. These algorithms are evaluated for strong theoretical security and run-time performance. NIST is in the third round of the competition, and the focus has shifted to analyzing the vulnerabilities to side-channel attacks. One algorithm that has gained notice is the Round 3 alternate …


Catalytic Activity Of Tungsten-Dioxo And Tungsten-Diimido Complexes, Kayla Denike Aug 2022

Catalytic Activity Of Tungsten-Dioxo And Tungsten-Diimido Complexes, Kayla Denike

Graduate Theses and Dissertations

Due to the significant decline in the availability of petrochemical resources and the increasing demand for the useful olefin mixtures extracted from oil, a sustainable and efficient alternative to these materials has become vital. Fortunately, renewable biomass derived materials may serve as a sustainable solution to the limited resources problem. Molecules derived from the degradation of biomasses are highly oxygenated and highly functionalized. Developing processes to efficiently defunctionalize these oxygen-rich materials will lead to potential up-conversion to carbon chemicals. Homogeneous catalytic deoxygenation processes present an opportunity to access valuable carbon commodity chemicals from biomass derived polyols. This dissertation details the …


The Effect Of Water Management And Ratoon Rice Cropping On Methane Emissions And Harvest Yield In Arkansas, Marguerita Leavitt Aug 2022

The Effect Of Water Management And Ratoon Rice Cropping On Methane Emissions And Harvest Yield In Arkansas, Marguerita Leavitt

Graduate Theses and Dissertations

Sustainable intensification of rice farming is crucial to meeting human food needs while reducing environmental impacts. Rice produces 8% of all anthropogenic CH4, which is a potent greenhouse gas. CH4 emissions can potentially be reduced by cultivation practices that minimize the number of days the fields are saturated, such as dry-seeding instead of water-seeding and irrigation using the alternate wetting and drying (AWD) technique instead of delayed, continuous flooding (DF). Ratoon cropping, wherein a second crop of rice is grown from the harvested stubble of the first crop, can be used to produce additional yield with minimal labor, but may …


Quantum Dots In Two-Dimensional Tungsten Diselenide, Jeb Allen Michael Stacy Aug 2022

Quantum Dots In Two-Dimensional Tungsten Diselenide, Jeb Allen Michael Stacy

Graduate Theses and Dissertations

This work focuses on the investigation of single and double quantum dots in two-dimensional transition metal dichalcogenide tungsten diselenide (WSe_2) as a means to evaluate the valley degree of freedom as a potential qubit and ambipolar tungsten diselenide monolayers as single photon sources. Gate-defined quantum dots in monolayer and bilayer WSe_2 were fabricated and characterized. Single dot devices are gated from above and below the WSe_2 to accumulate a hole gas. Temperature dependence of Coulomb-blockade peak height is consistent with single-level transport. Excited-state transport in the quantum dot is shown for both monolayer and bilayer devices. Magnetic field dependence of …


Effective Knowledge Graph Aggregation For Malware-Related Cybersecurity Text, Phillip Ryan Boudreau Aug 2022

Effective Knowledge Graph Aggregation For Malware-Related Cybersecurity Text, Phillip Ryan Boudreau

Graduate Theses and Dissertations

With the rate at which malware spreads in the modern age, it is extremely important that cyber security analysts are able to extract relevant information pertaining to new and active threats in a timely and effective manner. Having to manually read through articles and blog posts on the internet is time consuming and usually involves sifting through much repeated information. Knowledge graphs, a structured representation of relationship information, are an effective way to visually condense information presented in large amounts of unstructured text for human readers. Thusly, they are useful for sifting through the abundance of cyber security information that …


Competing Behaviors Of Thermoregulation And Ambush Foraging In The Timber Rattlesnake (Crotalus Horridus Horridus): A Mechanistic Assessment Of Thermal Conduction, Larry K. Kamees Aug 2022

Competing Behaviors Of Thermoregulation And Ambush Foraging In The Timber Rattlesnake (Crotalus Horridus Horridus): A Mechanistic Assessment Of Thermal Conduction, Larry K. Kamees

Graduate Theses and Dissertations

The interaction between the biophysical environment and ectotherm morphology elicits behaviors designed to maintain internal body temperature (Tb) within a range that promotes physiological functions. The short-term requirements of mass (energy requirements) and heat balance are subject to tradeoffs imposed by the organisms current physiological (heat and mass budgets) and environmental (biophysical, demographic, social, and predation) constraints and available resources. In temperate forests, extreme temperatures are common in summer even with intermittent sun exposure due to dense canopy cover. In Spring and Fall, temperatures can range from below freezing to 35 ℃ in 24 hrs. An ambush predator like the …


Improving Computation For Hierarchical Bayesian Spatial Gaussian Mixture Models With Application To The Analysis Of Thz Image Of Breast Tumor, Jean Remy Habimana Aug 2022

Improving Computation For Hierarchical Bayesian Spatial Gaussian Mixture Models With Application To The Analysis Of Thz Image Of Breast Tumor, Jean Remy Habimana

Graduate Theses and Dissertations

In the first chapter of this dissertation we give a brief introduction to Markov chain Monte Carlo methods (MCMC) and their application in Bayesian inference. In particular, we discuss the Metropolis-Hastings and conjugate Gibbs algorithms and explore the computational underpinnings of these methods. The second chapter discusses how to incorporate spatial autocorrelation in linear a regression model with an emphasis on the computational framework for estimating the spatial correlation patterns.

The third chapter starts with an overview of Gaussian mixture models (GMMs). However, because in the GMM framework the observations are assumed to be independent, GMMs are less effective when …


Crosscbr: Cross‑View Contrastive Learning For Bundle Recommendation, Yunshan Ma, Yingzhi He, An Zhang, Xiang Wang, Tat-Seng Chua Aug 2022

Crosscbr: Cross‑View Contrastive Learning For Bundle Recommendation, Yunshan Ma, Yingzhi He, An Zhang, Xiang Wang, Tat-Seng Chua

Research Collection School Of Computing and Information Systems

Bundle recommendation aims to recommend a bundle of related items to users, which can satisfy the users' various needs with one-stop convenience. Recent methods usually take advantage of both user-bundle and user-item interactions information to obtain informative representations for users and bundles, corresponding to bundle view and item view, respectively. However, they either use a unified view without differentiation or loosely combine the predictions of two separate views, while the crucial cooperative association between the two views' representations is overlooked.In this work, we propose to model the cooperative association between the two different views through cross-view contrastive learning. By encouraging …


Efficient Resource Allocation With Fairness Constraints In Restless Multi-Armed Bandits, Dexun Li, Pradeep Varakantham Aug 2022

Efficient Resource Allocation With Fairness Constraints In Restless Multi-Armed Bandits, Dexun Li, Pradeep Varakantham

Research Collection School Of Computing and Information Systems

Restless Multi-Armed Bandits (RMAB) is an apt model to represent decision-making problems in public health interventions (e.g., tuberculosis, maternal, and child care), anti-poaching planning, sensor monitoring, personalized recommendations and many more. Existing research in RMAB has contributed mechanisms and theoretical results to a wide variety of settings, where the focus is on maximizing expected value. In this paper, we are interested in ensuring that RMAB decision making is also fair to different arms while maximizing expected value. In the context of public health settings, this would ensure that different people and/or communities are fairly represented while making public health intervention …


Ransomsoc: A More Effective Security Operations Center To Detect And Respond To Ransomware Attacks, Anthony Cheuk Tung Lai, Ping Fan Ke, Kelvin Chan, Siu Ming Yiu, Dongsun Kim, Wai Kin Wong, Shuai Wang, Joseph Muppala, Alan Ho Aug 2022

Ransomsoc: A More Effective Security Operations Center To Detect And Respond To Ransomware Attacks, Anthony Cheuk Tung Lai, Ping Fan Ke, Kelvin Chan, Siu Ming Yiu, Dongsun Kim, Wai Kin Wong, Shuai Wang, Joseph Muppala, Alan Ho

Research Collection School Of Computing and Information Systems

Ransomware remains a major threat for organizations. Despite a lot of research done, existing solutions still have at least two shortcomings. (I) Slow detection time: by the time we realize that the system is under ransomware attack, almost all files have been encrypted. (II) Without a ransomwareaware backup scheme: Most existing systems, in particular those in SMEs (small and medium enterprises), do not have a proper backup system. Even they have it, either it is not a remote-site backup (i.e., files in the backup system may also be encrypted) or it is not designed for ransomware attacks. In this paper, …


Self-Checking Deep Neural Networks For Anomalies And Adversaries In Deployment, Yan Xiao, Ivan Beschastnikh, Yun Lin, Rajdeep Singh Hundal, Xiaofei Xie, David S. Rosenblum, Jin Song Dong Aug 2022

Self-Checking Deep Neural Networks For Anomalies And Adversaries In Deployment, Yan Xiao, Ivan Beschastnikh, Yun Lin, Rajdeep Singh Hundal, Xiaofei Xie, David S. Rosenblum, Jin Song Dong

Research Collection School Of Computing and Information Systems

Deep Neural Networks (DNNs) have been widely adopted, yet DNN models are surprisingly unreliable, which raises significant concerns about their use in critical domains. In this work, we propose that runtime DNN mistakes can be quickly detected and properly dealt with in deployment, especially in settings like self-driving vehicles. Just as software engineering (SE) community has developed effective mechanisms and techniques to monitor and check programmed components, our previous work, SelfChecker, is designed to monitor and correct DNN predictions given unintended abnormal test data. SelfChecker triggers an alarm if the decisions given by the internal layer features of the model …


Clostridioides Difficile Biofilm And Spore Production In Response To Antibiotics And Immune Stress, Adenrele M. Oludiran Aug 2022

Clostridioides Difficile Biofilm And Spore Production In Response To Antibiotics And Immune Stress, Adenrele M. Oludiran

Chemistry & Biochemistry Theses & Dissertations

The development of new therapeutic options against Clostridioides difficile (C. difficile) infection is a critical public health concern, as the causative bacterium is highly resistant to multiple classes of antibiotics. C. difficile, an anaerobic spore-forming Gram-positive pathogenic bacterium, is a major cause of hospital-acquired infections. C. difficile persists in the environment and spreads the infection to new hosts in the form of dormant spores and can persist within hosts as surface-attached biofilms. These studies investigate bacterial vegetative cell survival, biofilm formation, and sporulation in response to stress. Antimicrobial host-defense peptides (HDPs) are highly effective at simultaneously modulating …