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Articles 8281 - 8310 of 294572
Full-Text Articles in Physical Sciences and Mathematics
Environmental Monitoring In Shallow Lakes: Public Health Threats In Urban Waters, Kyleigh E. Johnson
Environmental Monitoring In Shallow Lakes: Public Health Threats In Urban Waters, Kyleigh E. Johnson
Theses and Dissertations
Lakes are an integral part of urban and suburban communities, providing ecological, recreational, and public health benefits. Many of these lakes are located in densely populated areas and are subject to urban influences on water quality. Algal toxins and Escherichia coli are two common recreational concerns. Algal toxins come from harmful algal blooms that are influenced by nutrient availability and temperature, while bacteria are often introduced through run-off and animal waste. Sampling every 3-4 weeks from May-October 2025 allowed for the assessment of seasonal patterns and site-specific differences across nine lakes in the Richmond area. The highest bacterial concentrations appeared …
Evaluating Willow Establishment With Biochar For Remediation Of Mine Waste Soils: Amendment Ph Determines Plant Biomass And Metal Mobility, Madeline R. Webb
Evaluating Willow Establishment With Biochar For Remediation Of Mine Waste Soils: Amendment Ph Determines Plant Biomass And Metal Mobility, Madeline R. Webb
Dissertations, Master's Theses and Master's Reports
Heavy metal contaminated mine tailings (“stamp sands”) from historic copper mining inhibit plant establishment and contribute to ongoing metal contamination. Biochar amendments may enhance plant growth and reduce metal mobility in highly permeable mine waste soils, but the efficacies of different application methods or biochar sources and composition are uncertain. We evaluated different biochar sources (neutral or alkaline pH) and application methods (either mixed or layered) for planted willow growth, moisture retention, and metal mobility. A 10-week growth chamber experiment assessed plant performance, heavy metal content and heavy metal mobility in soil leachates and plant tissues. Biochar pH was the …
Origin Of The World-Class Eagle, Eagle East, And Tamarack Ni-Cu-Pge Deposits And Comparative Analysis With Other Midcontinent Rift- And Siberian Trap-Related Intrusions, Robert M. Nowak
Dissertations, Master's Theses and Master's Reports
The 1.1 Ga Mesoproterozoic Midcontinent rift hosts the Eagle, Eagle East, and Tamarack Ni-Cu-PGE deposits and Embayment Prospect. These deposits are hosted by ultramafic igneous rocks and have some of the highest Ni-Cu grades on Earth. We use new bulk-rock data and published datasets (bulk-rock, mineral chemistry, and isotopic analyses) to examine major, minor, and trace element trends of both Midcontinent rift-related alkaline and tholeiitic intrusions. In addition, we compare the geochemical data to local kimberlite-hosted lower-crustal xenoliths and local igneous (Archean) and sedimentary (Paleoproterozoic) country rocks. We found the peridotite magma compositions dominantly consist of primitive mantle compositions with …
Artificial Elections: How Artificial Intelligence Can Affect Elections And Decide Our Future, Ryan D. Granger
Artificial Elections: How Artificial Intelligence Can Affect Elections And Decide Our Future, Ryan D. Granger
Honors Undergraduate Theses
This thesis examines the growing role of artificial intelligence (AI) in democratic elections, highlighting both its transformative potential and its associated risks. Drawing on a qualitative analysis of existing literature, the study explores how AI is increasingly integrated into political campaigns, election administration, and voter engagement. Key benefits include enhanced data analysis, personalized political messaging, and improved efficiency in campaign operations. AI also supports real-time fact-checking and more accurate vote tabulation, which can strengthen transparency and trust in electoral processes. However, the thesis emphasizes that these advantages are accompanied by significant challenges. AI technologies enable the rapid creation and dissemination …
Hybrid Patchtst And Physics-Based Framework For Predicting Lithium-Ion Battery State Of Health, Pavan Ravuri
Hybrid Patchtst And Physics-Based Framework For Predicting Lithium-Ion Battery State Of Health, Pavan Ravuri
Honors Undergraduate Theses
Accurately forecasting the state of health of lithium-ion batteries is critical for improving performance, reliability and lifetime in energy storage applications. Battery capacity degrades into a nonlinear pattern over cycling due to electrochemical processes where neither purely data driven nor physics-based models can capture alone. This study looks at a hybrid framework combining that PatchTST patch-based transformer architecture with physics-based features derived from the solid electrolyte interphase and pseudo two-dimensional models. Physics inspired proxy features were computed from cycling data and concatenated with electrochemical measurements as added input channels before patch segmentation. There are five model configurations that were evaluated …
Lie-Galois Theory, Giovanni Reed
Lie-Galois Theory, Giovanni Reed
Honors Undergraduate Theses
Differential equations are a much-studied topic in the field of mathematics, as well as other sciences, such as engineering, economics, and biology. While much is known concerning these, there is still a large gap in our knowledge about such equations. It is important therefore, both to mathematics and other sciences, that we gain a more complete knowledge of differential equations, in particular the nature of their solutions. In this research, we investigate the solution space of linear ordinary differential equations (ODEs) from the standpoint of differential algebra. Differential algebra allows an ODE to be treated similarly to a polynomial, allowing …
Dominating Hadwiger's Conjecture For 2k2-Free Graphs, Thomas Tibbetts
Dominating Hadwiger's Conjecture For 2k2-Free Graphs, Thomas Tibbetts
Honors Undergraduate Theses
A dominating Kt minor in a graph �� is a sequence (��1,…,��t) of pairwise disjoint non-empty connected subgraphs of ��, such that for 1≤��< ��≤��, every vertex in ��j has a neighbor in ��i. Replacing “every vertex in ��j” by “some vertex in ��j” retrieves the standard definition of a ��t minor. The strengthened notion was introduced by Illingworth and Wood in 2024, who asked whether every graph with chromatic number �� contains a dominating ��t minor. This is a substantial strengthening of the celebrated Hadwiger’s Conjecture, which asserts that every …
Balancing Evidence Recovery: Hexane’S Effect On Biological And Non-Biological Traces In Sexual Assault Kits, Maya Richards
Balancing Evidence Recovery: Hexane’S Effect On Biological And Non-Biological Traces In Sexual Assault Kits, Maya Richards
Honors Undergraduate Theses
This study investigated the effectiveness of solvent – based extraction methods for the recovery of lubricant residues from simulated sexual assault swabs, with emphasis on balancing chemical evidence recovery. Sequential extraction using ultra – pure water followed by organic solvents, hexane, dichloromethane (DCM), and ethyl acetate (EA), was evaluated across water – based, silicone – based, oil – based, and hygiene product matrices. Analysis was performed using Direct Analysis in Real Time – High Resolution Mass Spectrometry (DART – HRMS), and extraction efficiency was assessed through spectral correlation with neat reference samples. Results demonstrated that solvent performance was highly dependent …
From Lap To Map: How Musical Scale, Place, And Play Drive The Interconnected Mario Kart World, Cameron Cummins
From Lap To Map: How Musical Scale, Place, And Play Drive The Interconnected Mario Kart World, Cameron Cummins
Honors Undergraduate Theses
With their deserts, castles, and ghost houses, the environments of Super Mario games are colorful, whimsical, and charming, but why are they so compelling, and what happens when our analysis of these environments extends beyond individual levels to expansive game worlds? Drawing on Cresswell’s theory of place (2014) and recent work on musical place-building in Mario Kart 8 (Heazlewood-Dale, 2024), I propose a spectrum between localized and globalized scale in games. As game environments become increasingly globalized, the music may be similarly altered to account for this shift in scale. Consequently, players may then encounter a broader, less musically congruent …
Evaluating The Comparison Of Different Body Locations For Data Collection Using Galvanic Skin Response Of Forensic Chemistry Students When In Lecture And Laboratory Environments, Elisa Guerrero
Honors Undergraduate Theses
Anxiety is the response that humans can have when exposed to a stimulus. It can be caused by a multitude of factors, such as psychological, biological, or physiological stimuli. Anxiety can be presented as a state or as a trait in a person. Trait anxiety is typically seen as a more stable personality trait, whereas state anxiety is a more intense temporary emotional state. In our study, anxiety was regarded as a more state-like characteristic. A galvanic skin response (GSR) Shimmer3+ device can measure skin electro-conductance changes following stimulation. In a situation where a participant is experiencing anxiety, levels of …
High-Resolution Mapping Of Soil Moisture Variation Using Uas Thermal And Multispectral Imagery, Jackline Amma Timah
High-Resolution Mapping Of Soil Moisture Variation Using Uas Thermal And Multispectral Imagery, Jackline Amma Timah
Theses and Dissertations
In agricultural landscapes, soil moisture regulates hydrologic partitioning, nutrient transport and water quality, land-atmosphere energy exchange that shapes local climate, and ecosystem resilience. However, traditional monitoring approaches, such as in-situ sensors and satellite imagery, often lack the spatial resolution required to capture fine-scale soil moisture variability. This study evaluated whether unmanned aerial system (UAS)-derived thermal, multispectral, and terrain variables can capture fine-scale spatial variability in volumetric water content (VWC) within an SRB in central Illinois.
High-resolution imagery was collected and paired with 50 field-measured VWC observations. Land surface temperature (LST), vegetation indices (NDVI and NDRE), spectral bands, and slope were …
Characterizing A Low-Gradient Stream In Central Illinois As Gaining Or Losing And Observing Seasonal Changes In This Behavior, Eric Timothy Brunner
Characterizing A Low-Gradient Stream In Central Illinois As Gaining Or Losing And Observing Seasonal Changes In This Behavior, Eric Timothy Brunner
Theses and Dissertations
While the seasonal behaviors of low-gradient streams have been studied, the behavior of surface water and groundwater interactions within low-gradient streams in glaciated terrain is not fully understood. A third order, low-gradient glacial stream with a saturated riparian buffer in central Illinois was studied to determine the direction of flow between the surface water and groundwater. The goals of this study were to determine 1) whether the stream was gaining or losing water, and 2) whether the gaining or losing nature of the stream-aquifer system changes seasonally. At both an upgradient and downgradient location, two wells were installed: one in …
An Application Of Molecular Dynamics To Hed Plasma Physics: Point And Group Defect Diffusion In Coulomb Crystals, Levi Webb
Theses and Dissertations
Molecular dynamics (MD) simulations are used to explore the microscopic behaviors of complex systems that cannot be easily studied experimentally. In particular, the microphysics of high energy density (HED) astrophysical plasma environments remain inaccessible by modern experiment---even in laser facilities, these plasmas exist only on short timescales that do not lend easily to investigation. The diffusion of point and group defects through crystallized plasmas in the cores of white dwarfs and neutron star crusts, called Coulomb crystals, has potentially macroscopic implications for the evolution of these bodies. Thus, I employ the widely-used MD code LAMMPS to simulate small Coulomb crystal …
Type Ii Diabetes Treatment Comparison Via Compartment Modeling, Abigail M. Collins
Type Ii Diabetes Treatment Comparison Via Compartment Modeling, Abigail M. Collins
Theses and Dissertations
Type II diabetes mellitus affects one in ten adults worldwide, yet the effects of treatment type and adherence level on developing complications and quality of life have not been well characterized at the population level, and mathematical modeling offers a structured way to examine these dynamics. This thesis adapts the Boutayeb et al. (2004) model to incorporate dynamic treatment types and levels of adherence, producing nine scenarios in which complication development rate and complication recovery rate differed, to compare peak complications and quality of life across treatment and adherence conditions. Using a system of ordinary differential equations and compartment modeling, …
Evaluating The Role Of Power Electronics In Enhancing Renewable Energy And Smart Grid Performance: A Review, Muhammad Irfan Habib
Evaluating The Role Of Power Electronics In Enhancing Renewable Energy And Smart Grid Performance: A Review, Muhammad Irfan Habib
ASEAN Journal on Science and Technology for Development
The review article demonstrates the importance of power electronics in propelling the increase of renewables and increasing the efficiency of contemporary electrical grids. In particular, it highlights the need for bidirectional converters for effective energy management in vehicle-to-grid (V2G) systems with two-way power transfer. The paper examines the series of complications offered by the significantly large integration of power electronic converter-interfaced renewables, such as those related to system steadiness, power quality, and resignation bottlenecks. Also, it recognizes a mix of new technologies, such as wide bandgap (WBG) semiconductors like silicon carbide (SiC) and gallium nitride (GaN), that deliver superior performance …
Extraction And Characterization Of Fresh And Dehydrated Cactus (Opuntia Ficus Indica) Polysaccharide For Hydrogel Preparation, Aye Thwe Thwesoe, May Myat Khine
Extraction And Characterization Of Fresh And Dehydrated Cactus (Opuntia Ficus Indica) Polysaccharide For Hydrogel Preparation, Aye Thwe Thwesoe, May Myat Khine
ASEAN Journal on Science and Technology for Development
In this research, extraction of polysaccharide compounds from Cactus (Opuntia Ficus Indica) leaves in both fresh and dehydrated condition by solvent precipitation method using three types of water, acid (HCL) and NaOH. Before extraction, the physicochemical properties were examined to determine optimum yield (%) of extracted polysaccharide by optimization of Box-Behnken Design (BBD) of response surface methodology (RSM). The polysaccharide-based acrylamide hydrogel was prepared by free radical polymerization. The functional and structural characterization was done by FTIR, XRD and SEM for examination of extracted polysaccharide as raw polymer backbone in hydrogel preparation and prepared hydrogel as adsorbent for metal removal. …
Unlocking Green Potential In Indonesian Small Medium Enterprises: Challenges And Opportunities For Sustainable Vermicelli Production, Togar W. S. Panjaitan, Karina Agustin, Prayonne Adi, Jani Rahardjo, I Nyoman Sutapa
Unlocking Green Potential In Indonesian Small Medium Enterprises: Challenges And Opportunities For Sustainable Vermicelli Production, Togar W. S. Panjaitan, Karina Agustin, Prayonne Adi, Jani Rahardjo, I Nyoman Sutapa
ASEAN Journal on Science and Technology for Development
Due to limited initiatives and support, the transition to green manufacturing among small and medium enterprises (SMEs) in developing countries remains challenging. Through a critical literature review and case study of the Indonesian vermicelli industry, this study highlights the importance of collaboration and strong policies to address this. Other findings also reveal that the energy intensity and emissions in the sector exceed best practice benchmarks, with the cooking and drying stages contributing significantly to emissions due to high energy consumption. Lack of government regulations, company awareness, and understanding of applicable practices and technologies creates challenges in green manufacturing. The study …
Hybrid Model For Phishing Website Detection Using Transfer Learning, Atul Dubal, Mansi Subhedar, Santosh Dhamala, Manasi Patil
Hybrid Model For Phishing Website Detection Using Transfer Learning, Atul Dubal, Mansi Subhedar, Santosh Dhamala, Manasi Patil
ASEAN Journal on Science and Technology for Development
The rapid digitization of human activities has intensified reliance on internet-based platforms, creating fertile ground for cybercriminal exploits such as phishing. Despite advancements in detection mechanisms, phishing attacks continue to evolve, leveraging sophisticated visual mimicry to deceive users. This paper proposes a robust vision-based phishing detection system using ensemble deep learning to analyse webpage screenshots. The framework integrates transfer learning with pre-trained VGG16 and DenseNet121 models, extracting complementary low-level texture features (edges, gradients) and high-level hierarchical patterns (logos, layouts). These features are fused through a custom classifier with dropout regularization to mitigate overfitting. A balanced dataset of 3,000 webpage screenshots …
Ai-Assisted Hybrid Ga–Pso Channel Allocation Under 3gpp Tr 38.901 Uma For Efficient 5g Radio Resource Management, Sharada Narsingrao Ohatkar
Ai-Assisted Hybrid Ga–Pso Channel Allocation Under 3gpp Tr 38.901 Uma For Efficient 5g Radio Resource Management, Sharada Narsingrao Ohatkar
ASEAN Journal on Science and Technology for Development
The increased traffic and heterogeneity in the 5G/B5G network require efficient radio resource management (RRM). However, the existing methods, such as GA and PSO, have poor convergence speed and require proper initial conditions. Additionally, learning-based methods have high computational complexity. Hence, in this paper, a novel AI-assisted Hybrid Channel Allocation (AI–HCA) framework is proposed by using a support vector regression (SVR)-based predictive initialization method and GA-PSO optimization. Simulation results using the 3GPP UMa channel model show that the proposed method has a 28% reduction in call blocking probability (CBP), a 15-25% enhancement in spectral efficiency (SE), and a 18-25% enhancement …
Sustainable Conductive Rpla-Carbon Black Filament For Additive Manufacturing Via Single-Screw Extrusion, Zaidan Faraby Zulkarnain, Shakina Hawapi, Aini Zuhra Abdul Kadir, Muhd Ikmal Isyraf Mohd Maulana, Nor Akmal Fadil, Najlaa Nazihah Mas’Ood, Mohd Rizal Alkahari, Saidin Wahab
Sustainable Conductive Rpla-Carbon Black Filament For Additive Manufacturing Via Single-Screw Extrusion, Zaidan Faraby Zulkarnain, Shakina Hawapi, Aini Zuhra Abdul Kadir, Muhd Ikmal Isyraf Mohd Maulana, Nor Akmal Fadil, Najlaa Nazihah Mas’Ood, Mohd Rizal Alkahari, Saidin Wahab
ASEAN Journal on Science and Technology for Development
The growing demand for low-cost, sustainable conductive filaments for additive manufacturing motivates the exploration of recycled polymer feedstocks as alternatives to virgin materials. However, the effects of prior thermal reprocessing on both the electrical performance and morphological integrity of recycled PLA (rPLA)–carbon black (CB) composite filaments remain insufficiently characterised, particularly under single-screw extrusion conditions. This study fabricates and characterises conductive filaments from virgin PLA and rPLA, each loaded with CB at 0.2, 0.6, and 1.0 wt%, using a low-cost desktop single-screw extruder. Melt blending was found to be essential for achieving continuous filament extrusion, as ball milling produced insufficient filler …
Assessing Glacial Mass Change And Its Impact On Water Resources In Parts Of The Himalayas Using Satellite Remote Sensing, Kriti Panta
Theses and Dissertations
This study investigates long-term changes in terrestrial water storage and their impact on hydrological processes in glacier-fed regions of Nepal. The study focuses on the central to eastern Himalayan region, including major river basins within the Koshi system. Multiple datasets, including the Gravity Recovery and Climate Experiment (GRACE) and GRACE follow-on (GRACE-FO) missions satellite data, the Global Land Data Assimilation System (GLDAS) products, and in situ streamflow data, were used for the period 2002–2019. Terrestrial Water Storage Anomaly (TWSA) derived from GRACE data shows a strong decreasing trend over time, indicating significant water storage loss across the study area. Soil …
Modeling The Impact Of Projected Water Demand On Groundwater Flow And Transport In The Mahomet Aquifer, Christabel Chinonye Abugu
Modeling The Impact Of Projected Water Demand On Groundwater Flow And Transport In The Mahomet Aquifer, Christabel Chinonye Abugu
Theses and Dissertations
The Mahomet Aquifer is a vital groundwater resource in east-central Illinois, supporting municipal, agricultural, and industrial water use. With projected changes in water demand driven by population growth and future socioeconomic conditions, assessing the long-term response of the aquifer is critical for sustainable groundwater management. Increased pumping to meet future demand may contribute to groundwater-level decline, intensified cones of depression, and altered groundwater-flow paths relevant to contaminant migration. This study addressed two research questions: (1) how projected changes in groundwater demand affect groundwater levels in the Mahomet Aquifer, and (2) how projected demand influences groundwater-flow paths relevant to contaminant migration. …
Spectroscopic And Structural Characterization Of Unexpected Porphyrinoid Byproducts Resulting From The Reaction Of A Cyclopentadiene Trialdehyde With N-Alkyltripyrranes, Kimberly Le, Gregory M. Ferrence, Timothy D. Lash
Spectroscopic And Structural Characterization Of Unexpected Porphyrinoid Byproducts Resulting From The Reaction Of A Cyclopentadiene Trialdehyde With N-Alkyltripyrranes, Kimberly Le, Gregory M. Ferrence, Timothy D. Lash
Faculty Publications – Chemistry
Acid-catalyzed condensation of N-alkyltripyrranes with a cyclopentadiene trialdehyde, followed by oxidation with aqueous ferric chloride solutions, gave unusual tripyrrolic byproducts in addition to previously reported carbaporphyrins and oxycarbaporphyrins. These stable nonaromatic structures incorporate aldehyde substituents, macrocyclic ketones, two conjugated pyrrole units, and a pyrrolo[1,2-a]pyrrole moiety. The NMR and UV-vis data were consistent with a nonaromatic system, and single-crystal X-ray diffraction confirmed that these structures are highly distorted. Structural characterization of a related aromatic carbaporphyrin triketone was also accomplished.
Detection And Quantification Of Spreading Depolarization In Drosophila Melanogaster Using High-Throughput, Wide-Field Brain Imaging, Wolfgang Stein, Allison L. Harris
Detection And Quantification Of Spreading Depolarization In Drosophila Melanogaster Using High-Throughput, Wide-Field Brain Imaging, Wolfgang Stein, Allison L. Harris
Faculty publications – Physics
Spreading depolarization (SD) is a ubiquitous neural phenomenon implicated in mammalian neurological disorders including cerebral ischemia, brain death, stroke, brain injury, and migraine, as well as in insect chill coma. During SD, a breakdown of ion homeostasis and a slowly spreading wave of neural depolarization leads to processing deficits, such as sensory disturbances and paralysis. Our protocols introduce high-throughput techniques using wide-field fluorescence brain imaging in Drosophila melanogaster larvae and adults to detect and quantify the spatial and temporal dynamics of SD and its initiation points. Two SD initiation techniques, rapid cooling and pharmacological manipulation, are detailed. The larval protocols …
A Nuclear Terrorism Scenario: Improvised Nuclear Weapons With 60%-Enriched Uranium, Matt Caplan
A Nuclear Terrorism Scenario: Improvised Nuclear Weapons With 60%-Enriched Uranium, Matt Caplan
Faculty publications – Physics
In this work we show that approximately 60–70 kg of 60%-enriched uranium can be used to build a crude nuclear weapon with a kiloton yield. While too large to fit on a missile, such a weapon could be delivered by a shipping container. This analysis is motivated by the June 2025 Israeli and US attacks on Iran, especially the bombings of the nuclear facilities at Natanz, Fordow and Isfahan. The Iranian stockpile of approximately 440 kg of 60%-enriched uranium is, at the time of writing, inaccessible to IAEA inspectors and stored in secret. The rapid clandestine relocation of this material …
Environmental Engineers Develop Solutions To Problems Of Planetary Health: The Legacy Of Professor P. Aarne Vesilind, Daniel B. Oerther
Environmental Engineers Develop Solutions To Problems Of Planetary Health: The Legacy Of Professor P. Aarne Vesilind, Daniel B. Oerther
Civil, Architectural and Environmental Engineering Faculty Research & Creative Works
The principal ethical obligation of the engineering profession, to "hold paramount the health, safety, and welfare of the public," has been challenged for decades. Professor P. Aarne Vesilind identified two primary deficiencies: an anthropocentric bias that values nature only instrumentally and the use of non-mandatory, aspirational language for environmental protection, which resulted in the exclusion of enforceable environmental canons. This paper argues that two recent developments provide a comprehensive response to Vesilind's recommendations for engineering ethics. First, the United States Bureau of Labor Statistics has redefined environmental engineering as "developing solutions to problems of planetary health." Second, Oerther proposed a …
Wearable Sensor-Based Phase Segmentation Analysis Of Front Crawl Swimming: A Scoping Review, Jonathan Simoes, Samuel Aylward, Daniel Hamze, Daniel James Goble, Daniel M. Russell, Joshua Haworth
Wearable Sensor-Based Phase Segmentation Analysis Of Front Crawl Swimming: A Scoping Review, Jonathan Simoes, Samuel Aylward, Daniel Hamze, Daniel James Goble, Daniel M. Russell, Joshua Haworth
Exercise Science Faculty Publications
Front crawl swimming stroke phase segmentation has historically relied on video analysis, but the development of wearable sensor technology has created new opportunities for automated phase segmentation. This scoping review mapped the available evidence on wearable sensor-based stroke phase segmentation methods in front crawl swimming, following PRISMA-ScR guidelines. A systematic search of SPORTDiscus, Web of Science, and IEEE Xplore conducted from January to June 2026, identified 15 eligible peer-reviewed studies published between 2000 and 2024. The review revealed an emerging field of research that has converged methodologically around inertial measurement units (IMUs) and the Chollet phase segmentation framework while remaining …
Reply To: S. N. Katkuri Et Al. And H. Liu Et Al. On Early And Sustained Improvements In Sense Of Smell With Tezepelumab Treatment In Patients With Chronic Rhinosinusitis With Nasal Polyps (Waypoint), Joaquim Mullol, Joseph K. Han, Tanya M. Laidlaw, Claire Hopkins, Anju T. Peters, Oliver Pfaar, Martin Desrosiers, Stella E. Lee, Andrew P. Lane, Claudia Chen, Yun Chon, Sandhia S. Ponnarambil, Andrew Foster, Andrew W. Lindsley, Christopher S. Ambrose
Reply To: S. N. Katkuri Et Al. And H. Liu Et Al. On Early And Sustained Improvements In Sense Of Smell With Tezepelumab Treatment In Patients With Chronic Rhinosinusitis With Nasal Polyps (Waypoint), Joaquim Mullol, Joseph K. Han, Tanya M. Laidlaw, Claire Hopkins, Anju T. Peters, Oliver Pfaar, Martin Desrosiers, Stella E. Lee, Andrew P. Lane, Claudia Chen, Yun Chon, Sandhia S. Ponnarambil, Andrew Foster, Andrew W. Lindsley, Christopher S. Ambrose
Department of Otolaryngology (ENT) Faculty Publications
[Introduction] We thank Dr. S. N. Katkuri, Dr. H. Liu, and their coauthors [1, 2] for their interest in our recent publication describing the improvements in loss of smell symptoms with tezepelumab versus placebo in patients with uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP) in the WAYPOINT trial (NCT04851964) [3]. We are grateful for the authors' feedback on the clinical significance of the data presented and their appreciation of the consistency observed across a range of baseline clinical characteristic and demographic subgroups.
Use Of Tezepelumab For Chronic Rhinosinusitis With Nasal Polyps By Eosinophilic Endotype: Waypoint Post-Hoc Analysis, Shigeharu Fujieda, Nobuyoshi Otori, Joseph K. Han, Tadataka Yabuta, Claudia Chen, Claudio Marchese, Andrews Foster, Sandhia S. Ponnarambil, Yun Chan, Brian J. Lipworth
Use Of Tezepelumab For Chronic Rhinosinusitis With Nasal Polyps By Eosinophilic Endotype: Waypoint Post-Hoc Analysis, Shigeharu Fujieda, Nobuyoshi Otori, Joseph K. Han, Tadataka Yabuta, Claudia Chen, Claudio Marchese, Andrews Foster, Sandhia S. Ponnarambil, Yun Chan, Brian J. Lipworth
Department of Otolaryngology (ENT) Faculty Publications
Background
The phase 3 WAYPOINT study (NCT04851964) reported that tezepelumab improved outcomes in patients with chronic rhinosinusitis with nasal polyps (CRSwNP), including nasal polyp size, nasal congestion, and sinonasal symptoms, and reduced the need for surgery and systemic corticosteroids (SCS).
Objective
To evaluate the efficacy and safety of tezepelumab across Japanese Epidemiological Survey of Refractory Eosinophilic Chronic Rhinosinusitis-defined eosinophilic chronic rhinosinusitis (ECRS) subgroups.
Methods
Adults with severe CRSwNP were randomized to tezepelumab 210 mg or placebo every 4 weeks. Coprimary end points were the change from baseline to week 52 in total Nasal Polyp Score and the biweekly mean Nasal …
Computational Insights Into Orthotropic Fracture: Crack-Tip Fields In Strain-Limiting Materials Under Non-Uniform Loads, Saugata Ghosh, Dambaru Bhatta, S. M. Mallikarjunaiah
Computational Insights Into Orthotropic Fracture: Crack-Tip Fields In Strain-Limiting Materials Under Non-Uniform Loads, Saugata Ghosh, Dambaru Bhatta, S. M. Mallikarjunaiah
School of Mathematical & Statistical Sciences Faculty Publications
A finite element framework is presented for analyzing crack-tip phenomena in transversely isotropic, strain-limiting elastic materials. Mechanical response is characterized by an algebraically nonlinear constitutive model, relating stress to linearized strain. Non-physical strain singularities at the crack apex are mitigated, ensuring bounded strain magnitudes. This methodology significantly advances boundary value problem (BVP) formulation, especially for first-order approximate theories. For a transversely isotropic elastic solid with a crack, the governing equilibrium equation, derived from linear momentum balance and the nonlinear constitutive model, is reduced to a second-order, vector-valued, quasi-linear elliptic BVP. This BVP is solved using a robust numerical scheme combining …