Physical Sciences and Mathematics Commons^™

Development Of Photolabile Coumarin Linker For Rna Synthesis And Crisprcas9 Applications, Ian Mcclain

Electronic Theses & Dissertations (2024 - present)

The scope of RNA-based therapeutics continues to expand as more siRNA, mRNA, and CRISPR-based treatments are approved for various medical applications. Purification of synthetic RNA drugs is inherently challenging and requires considerable time and resources. New cost-effective and efficient purification strategies will expedite drug development process and will lower the drug costs. In this thesis I describe two generations of photolabile linkers for the non-chromatographic purification of therapeutic RNAs. In addition, the photolabile linker was utilized for regulation CRISPR-Cas9 gene editing. In the first part of the thesis, I describe the first generation of the photolabile coumarin-based linker for non-chromatographic …

Design, Fabrication Modeling, And Optical Metrology Of Mwir Silicon Metalenses, Weiyu Chen

Graduate Studies Theses and Dissertations 2026

Mid-wave infrared (MWIR) optical systems require compact, broadband, manufacturable components whose performance can be predicted and measured reliably. Silicon metalenses are attractive because silicon combines high refractive index, MWIR transparency, and semiconductor-compatible fabrication. This dissertation develops a scale-bridging design–fabrication-modeling–metrology framework for MWIR silicon metalenses.

A shared full-aperture framework connects meta-atom libraries, physical layout generation, angular-spectrum propagation, point-spread-function calculation, and focal-plane energy metrics. Building on this foundation, the Dispersive Sweatt Model (DSM) incorporates meta-atom dispersion into conventional ray-tracing software, enabling broadband co-optimization of metasurfaces and refractive elements. A process-aware design framework then incorporates scanning electron microscopy (SEM)-measured height–radius relationships produced by …

Machine Learning For Economists, John Luke Gallup

Economics Faculty Publications and Presentations

Explication of machine learning algorithms and their usefulness for economic research. The prediction algorithms of Random Forest, Gradient Boost Machines, Neural Networks and Support Vector Machines are built from simple steps applied at large scale to generate surprisingly precise nonlinear estimates. Although useful for processing and interpreting new forms of data, their application to economics research is limited because they do not provide readily interpretable evidence of the causes of outcomes.

From Lap To Map: How Musical Scale, Place, And Play Drive The Interconnected Mario Kart World, Cameron Cummins

Honors Undergraduate Theses

With their deserts, castles, and ghost houses, the environments of Super Mario games are colorful, whimsical, and charming, but why are they so compelling, and what happens when our analysis of these environments extends beyond individual levels to expansive game worlds? Drawing on Cresswell’s theory of place (2014) and recent work on musical place-building in Mario Kart 8 (Heazlewood-Dale, 2024), I propose a spectrum between localized and globalized scale in games. As game environments become increasingly globalized, the music may be similarly altered to account for this shift in scale. Consequently, players may then encounter a broader, less musically congruent …

Artificial Elections: How Artificial Intelligence Can Affect Elections And Decide Our Future, Ryan D. Granger

Honors Undergraduate Theses

This thesis examines the growing role of artificial intelligence (AI) in democratic elections, highlighting both its transformative potential and its associated risks. Drawing on a qualitative analysis of existing literature, the study explores how AI is increasingly integrated into political campaigns, election administration, and voter engagement. Key benefits include enhanced data analysis, personalized political messaging, and improved efficiency in campaign operations. AI also supports real-time fact-checking and more accurate vote tabulation, which can strengthen transparency and trust in electoral processes. However, the thesis emphasizes that these advantages are accompanied by significant challenges. AI technologies enable the rapid creation and dissemination …

Hybrid Patchtst And Physics-Based Framework For Predicting Lithium-Ion Battery State Of Health, Pavan Ravuri

Honors Undergraduate Theses

Accurately forecasting the state of health of lithium-ion batteries is critical for improving performance, reliability and lifetime in energy storage applications. Battery capacity degrades into a nonlinear pattern over cycling due to electrochemical processes where neither purely data driven nor physics-based models can capture alone. This study looks at a hybrid framework combining that PatchTST patch-based transformer architecture with physics-based features derived from the solid electrolyte interphase and pseudo two-dimensional models. Physics inspired proxy features were computed from cycling data and concatenated with electrochemical measurements as added input channels before patch segmentation. There are five model configurations that were evaluated …

The Role Of Resistance Training In Managing Menopause-Related Changes, Alyson K. Strauss

Honors Undergraduate Theses

Resistance training serves as a critical non-pharmacological strategy for mitigating the physiological and psychological declines associated with the menopausal transition. This natural biological phase, marked by declining estrogen levels, typically leads to accelerated bone mineral density loss, sarcopenia, metabolic regulation disturbance, and heightened mood disturbances. To evaluate the efficacy of targeted exercise interventions, a systematic review was conducted following PRISMA guidelines. From an initial pool of 60 relevant articles, 13 studies met the specific inclusion criteria, focusing on structured resistance training protocols for perimenopausal, menopausal, and postmenopausal cohorts.

The synthesis of these studies indicates that resistance training is a highly …

Co2 Enhanced Oil Recovery In The Dickinson Lodgepole Mounds, University Of North Dakota. Energy And Environmental Research Center

EERC Brochures and Fact Sheets

Fact sheet about CO₂ enhanced oil recovery (EOR) in the Dickinson Lodgepole Mounds of Stark County, North Dakota. Includes geological information and how stored CO₂ increases local oil production.

Identification And Characterization Of Tornado Seismic Signals In The Central U.S., Seth Thompson

Theses and Dissertations--Earth and Environmental Sciences

Tornadoes cause extensive property damage and endanger lives. While Doppler radar can indicate the potential for tornado development, it cannot confirm that a tornado is in contact with the ground unless a debris signature is present. While on the ground, a significant amount of a tornado’s energy may be transferred into the earth as seismic vibrations. Thus, seismometers have the potential to detect on-the-ground tornadoes. Since 1960, only five papers have published seismic recordings from tornadoes. These studies have mostly reported on seismic waves generated by tornadoes at a relatively large range, from 0.01-2.5 Hz, representing uncertainty in the dominant …

Supporting Data – T-3 Stream Stage And Streambed Well Data, Mclean County, Il, April 12, 2025 To November 1, 2025, Eric Wade Peterson, Eric Brunner

Faculty Publications - Geography, Geology, and the Environment

Between April 12, 2025, and November 1, 2025, observation wells at the T-3 site in central Illinois were monitored at an upstream and downstream site along the stream. A conductivity, depth, and pressure (CTD) sensor inside each well collected continuous in-situ measurements for the water column height (mm), the water temperature (°C), and the water conductance (mS/cm). The available dataset provides in-situ readings every 15-minutes from seven (7) locations: upstream stream, streambed, and shallow aquifer, downstream stream, streambed, and shallow aquifer, and Well 12, and provides the air temperature.

Þingmúli Revisited: New Zircon-Based Perspectives On Rhyolite Petrogenesis In Iceland, Tenley J. Banik, Tamara L. Carley, Cameron D. Essex, Gabriella M. Montano

Faculty Publications - Geography, Geology, and the Environment

Þingmúli (Thingmuli), an extinct volcano in eastern Iceland, has long been an archetype for fractional crystallization of tholeiitic basalt to produce rhyolite. However, a recent re-examination of Þingmúli suggests that some silicic magmas were produced under more oxidizing conditions from a combination of magma mixing and assimilation, thereby indicating two petrogenetic pathways. We present the first zircon-based analyses from Þingmúli to evaluate the extent to which the zircon record corroborates these recent findings. Zircon U-Pb age dates of ~ 8.5–10 Ma agree with published whole-rock and regional values. Zircon ε_Hf ranges from ~ + 13.6 to 16.3; zircon δ …

Integer-Valued Time Series Model Via Copula-Based Bivariate Skellam Distribution, Mohammed Alqawba, Norou Diawara, Mame Mor Sene

Mathematics & Statistics Faculty Publications

Time series analysis is crucial for modeling and forecasting diverse real-world phenomena. Traditional models typically assume continuous-valued data; however, many applications involve integer-valued series, often including negative integers. This paper introduces an approach that combines copula theory with the bivariate Skellam distribution to handle such integer-valued data effectively. Copulas are widely recognized for capturing complex dependencies among variables. By integrating copulas, our proposed method respects integer constraints while modeling positive, negative, and temporal dependencies accurately. Through simulation and an empirical study on a real-life example, we demonstrate that our class of models performs well. This approach has broad applicability in …

The Sub-Lethal Effects Of Trematode Parasites On The Migratory Behavior Of Lesser Scaup (Aythya Affinis), Scott Alan Herman

Graduate Research Theses & Dissertations

The introduction of the invasive freshwater faucet snail (Bithynia tentaculata) and its associated parasites in the Upper Mississippi River and Great Lakes Region provides the opportunity to investigate how anthropogenic stressors impact the life history of lesser scaup (Aythya affinis) using the Mississippi Flyway. To understand the life histories and interactions between lesser scaup and faucet snails we examined historical records, research, and ecology textbooks. Our literature review identified critical knowledge gaps in lesser scaup literature surrounding population dynamics, reproduction, and migration. Specifically, the sub-lethal effects of invasive trematodes on the migratory behavior of lesser scaup in the Upper Mississippi …

Emergent Spin Fluctuation And Structural Metastability In Self-Intercalated Cr1+Xte2 Compounds, Clayton Conner, Ali Sarikhani, Theo Volz, Mathew Pollard, Mitchel Vaninger, Xiaoqing He, Steven Kelley, Jacob Cook, Avinash Sah, John Clark, Hunter Lucker, Cheng Zhang, Paul Miceli, Yew San Hor

Physics Faculty Research & Creative Works

Intercalated van der Waals (vdW) magnetic materials host unique magnetic properties due to the interplay of competing interlayer and intralayer exchange couplings, which depend on the intercalant concentration within the van der Waals gaps. Magnetic vdW compound chromium telluride, (Formula presented.), has demonstrated rich magnetic phases at various Cr concentrations, such as the coexistence of ferromagnetic and antiferromagnetic phases in (Formula presented.) (equivalently, (Formula presented.)). The compound is created by intercalating 0.25 Cr atom per unit cell within the van der Waals gaps of (Formula presented.). In this work, we report a notably increased Curie Temperature and an emergent in-plane …

Analyzing A Benchtop Model Of Combined Heat Power To An Industrial Scale, Chase Steven Carlton, Ashley Leach, Andrew Martin-Biggs, Tessa Wilker

UNH URC Open (2026 and after)

Analyzing a Benchtop Model of Combined Heat Power to an Industrial Scale

Spectral Phase Pulse Shaping Alters Photoionization Time, James Aygun, Dany Yaacoub, Allison L. Harris

Faculty publications – Physics

Photoionization is a key step in many attosecond processes. Accurately determining the photoionization time delay is critical to understanding electron dynamics during and after ionization and can guide future efforts to manipulate electron motion. Prior studies have shown that the photoionization time delay is non-zero and that pulse shaping through alteration of the spectral phase may change the number and timing of ionization events. In order to assess whether and how the spectral phase modifies the photoionization time delay, we use attosecond streaking simulations to extract the streaking time delay for ionizing pulses with identical power spectra, but different spectral …

Technological Interventions For Reducing Climate Change Impacts On Health: An Overview Of Future Possibilities, Sujatha Alla, Vijay Kumar Chattu, Bawa Singh

Engineering Management & Systems Engineering Faculty Publications

Globally, over five million deaths annually are attributed to extreme weather events exacerbated by climate change, such as heatwaves, hurricanes, wildfires, droughts, and floods, which create health crises and economic losses. The 2015 Paris Declaration emphasized climate technology mechanisms, including research and development, to enhance resilience and reduce greenhouse gas emissions. Biotechnological advancements have mitigated about 20% of economic losses since the 1960s, highlighting technology’s potential to address climate-induced health risks.

A Comprehensive Survey On Facial Expression Generation: From Gans To Llm-Guided Multimodal Models, Murad Hasan, Rabab Abdelfattah, Kareem Abdelfatah, Mostafa Fouda, Ahmed Sherif

Faculty Publications

Facial expression generation (FEG) has emerged as a vital area in human–computer interaction, virtual avatars, and affective computing, aiming to synthesize natural and expressive facial behaviors across diverse interaction contexts. This survey presents a comprehensive analysis of recent advances in FEG, organized into six key paradigms: speech-driven expression generation, facial reaction generation, face video generation, facial animation, avatar-based generation, and text-driven expression generation. We review a wide range of model architectures, including VQ-VAEs, Generative Adversarial Networks (GANs), 3D Morphable Models (3DMMs), Transformers, and diffusion-based approaches, and compare their performance using commonly adopted evaluation metrics such as Fréchet Distance (FD), Peak …

Climate Change Effects On Biomass And Greenhouse Gas Emissions Are Ameliorated By Nontoxic Endophytes In Southeastern Usa Transition Zone Tall Fescue Pastures, Rebecca Kay Mcgrail, Jonathan D. Moore, A. Elizabeth Carlisle, Jim A. Nelson, Rebecca L. Mcculley

Plant and Soil Sciences Faculty Publications

Background: The plant–microbe interaction between tall fescue and its endophyte Epichloë coenophiala can affect ecosystem responses to changing rainfall patterns and increasing temperatures. Endophyte-infected (E+) stands often exhibit improved stress tolerance and differing soil greenhouse gas (GHG) emissions compared to endophyte-free (E−) stands. However, it is unknown if mammalian nontoxic endophyte (NTE) strains introduced into some tall fescue cultivars confer differing stress tolerances or reduce soil GHG emissions.

Methods: We quantified the impact of fescue-NTE symbioses in Jesup and Texoma on biomass and GHG emissions in response to increased temperature (+3°C) and altered precipitation (50% lengthened interval between events) using …

A Global Synthesis Of Fragipan Silicon Concentrations And Relationships With Soil Physicochemical Properties As A Function Of Soil Parent Materials, Christopher Shepard

Plant and Soil Sciences Faculty Publications

Fragipans are dense, brittle subsurface horizons that restrict root growth and limit water-holding capacity. A common factor in these soils is a binding agent, potentially either phyllosilicate clay bridging, amorphous aluminosilicate/silica, or silica sorbed to Fe oxides. Others have suggested that no binding agent is present within these soil horizons and that the arrangement of individual particles is solely responsible for these horizons. In this article, a secondary data synthesis was utilized to demonstrate that silicon (Si) accumulation is a key pedogenic process in loess-derived fragipan horizons, but not in all fragipans. The average dithionite-extractable Si (Si_d) content …

Pixel-To-World Mapping For Multi-Camera Warehouse Robot Localization, Mariam Faruque Sharif

College of Graduate Studies: Theses & Dissertations

This thesis presents a comprehensive framework for camera calibration and pixel-to-world coordinate mapping for multi-camera robot localization in a structured warehouse environment. The study is conducted in the APRN-ROWS laboratory, where four overhead cameras observe a planar grid of known barcode locations used as the reference coordinate system.

The proposed approach combines geometric modeling and optimization-based techniques to estimate camera parameters. Initially, camera extrinsic parameters, including position and orientation, are derived using physical measurements and geometric relationships. Principal point locations are estimated through a zoom-based alignment method, ensuring accurate correspondence between the optical axis and the world coordinate system. Intrinsic …

Monitoring Long-Term Water Quality Benefits Of Urban Stream Restoration, Kira Burnett

2026 Research Poster Competition

Urbanization without conscious environmental planning can result in the degradation of stream ecosystems. This tends to result in urban stream syndrome, which is often characterized by increased sediment and nutrient concentrations, decreased biodiversity, more frequent flash flooding, and overall water quality degradation. As such, stream restoration practices are often implemented to address urban stream syndrome. Commonly used restoration practices include applying natural channel design to stabilize eroding stream banks and establishing diverse streamside vegetation to filter pollutant inputs. However, the benefits of restoration are not often quantified due to a lack of post-restoration monitoring, making it challenging to determine what …

Developing Bioassays For Detection Of Residual Herbicides In Compost, Esther Moore

2026 Research Poster Competition

Developing Bioassays for Detection of Residual Herbicides in Compost, the use of synthetic herbicides has dominated the field of agricultural production for over a century. While synthetic herbicide use has resulted in an undeniable boost in agricultural productivity, risks such as environmental degradation and reduced yield of non-target plant species must be considered. Key among these risks is compost contamination, especially from persistent herbicides. After these herbicides are applied, they are absorbed by growing vegetation, consumed by herbivores, passed through the digestive tract, and reintroduced into soil manure based compost. Even after this process, chemicals in such herbicides can remain …

Modeling The Development Of Keyhole Passage Morphology, Charlotte Boehme

2026 Research Poster Competition

Cave passage morphology is an important indicator of the hydrological conditions under which a cave passage was formed. Keyhole passages are a commonly occurring type of passage morphology that consists of a round, wide top with a smaller canyon incised in the bottom of the passage. These passages typically indicate a shift from fully water-filled to partially water-filled conditions. There are multiple mechanisms by which such a transition can occur, and little is understood about which of these mechanisms is most common, or whether aspects of keyhole passage morphology may indicate the primary formation mechanism. CaveCHAMP is a physically based …

Optimizing Microscale Tesla Valve Design For Enhanced Efficiency For Filtering And Sorting Bacteria, Brian Ewalt

2026 Research Poster Competition

Invented by Nikola Tesla in 1920, a Tesla valve is a passive check valve with no moving parts but showing diodicity for fluids (i.e., allowing fluids to flow easily in one direction but not in the other). Tesla valves have demonstrated remarkable versatility across a range of scientific fields. Recently, a study conducted at the University of Arkansas showed that these conduits exhibited diodicity for bacteria in the absence of fluid flows (Rogers et al. 2023), serving as proof of concept for applying microscale Tesla valves for filtering and sorting bacteria and microorganisms in biomedical settings. However, the design of …

Chronostratigraphy Using Stable Carbon Isotopes Of The Elliot Formation, South Africa, Aidan Del Pino

2026 Research Poster Competition

The Elliot Formation in South Africa preserves a fossil-bearing record spanning the Late Triassic–Early Jurassic, a time marked by significant environmental changes related to the Central Atlantic Magmatic Province (CAMP) and the end-Triassic extinction event. Despite its importance, the Elliot Formation remains poorly constrained due to limited chronostratigraphic markers. Chronostratigraphy is the branch of geology that correlates and dates rock units in time, allowing researchers to arrange these rock units into a chronological sequence. Globally, the Triassic–Jurassic boundary is characterized by a pronounced negative carbon isotope excursion linked to CAMP volcanism and the end Triassic extinction event. This C-isotope excursion …

Temporal Variational Graph Autoencoder For Influenza Evolution, Soumya Chauhan

2026 Research Poster Competition

Frequent mutations in influenza virus surface proteins can increase infectivity while evading human and vaccine immunity, causing seasonal epidemics. The CDC annually evaluates thousands of virus strains to predict mutated sequences likely to be dominant in the next season, which creates a need for methods that better capture how viral mutations evolve over time. In this study, we represent influenza protein sequences as a network-like graph, creating connections if sequences are collected a week apart and only differ by one mutation. This method explicitly considers time information as part of the evolution, while other existing methods analyze mutated sequences without …

Uav-Based Sensor Integration For In-Situ Lake Water Quality Monitoring, Alec Campbell

2026 Research Poster Competition

Current water quality assessment methods rely heavily on manual sampling and laboratory analysis, which are time-consuming and difficult to perform in remote or hazardous environments. In surface water monitoring, spatial and temporal resolution is often constrained by labor, access, and logistical limitations of manual sampling programs. This research aims to develop a drone-based system for real-time, in situ lake water quality monitoring. To address these challenges, the project focuses on integrating multiple water quality sensors, including oxidation-reduction potential (ORP), pH, electrical conductivity (EC), turbidity, and a multispectral spectrometer, into a compact, UAV-compatible design capable of collecting spatially referenced data. Methods: …

Flair- Flow-Level Anomaly Intrustion Recognition, Joseph Dumond

2026 Research Poster Competition

Industrial control systems (ICS) and industrial Internet of Things (IIoT) networks support critical infrastructure such as power generation, water treatment, and manufacturing. As these systems become more connected, they are increasingly exposed to cyber threats. However, many existing intrusion detection approaches rely on detailed packet inspection or supervised machine learning techniques that require labeled attack data and extensive tuning, making them difficult to deploy in real industrial environments.ICS networks typically generate highly regular and predictable communication patterns due to periodic control logic and deterministic device behavior. Because of this structure, abnormal or malicious activity often appears as a disruption to …

When Relevant Isn’T Readable: Evaluating Cognitive Accessibility In Search, Kaija Frierson

2026 Research Poster Competition

According to the World Health Organization, more than one billion people worldwide experience some form of disability. Many of them may affect cognitive processing and reading comprehension rather than vision or mobility, which creates barriers when accessing written information online. Web search is a critical modern literacy skill used for learning, decision-making, and everyday problem solving, yet most search systems are designed with the assumption that all users can process complex written language equally. As a result, people with dyslexia, other cognitive disabilities, low literacy levels, or who are English language learners may struggle to access relevant information even when …